WO2003051365A3 - Utilisation de composes de la famille des benzamides comme agent immunosuppresseur - Google Patents

Utilisation de composes de la famille des benzamides comme agent immunosuppresseur Download PDF

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Publication number
WO2003051365A3
WO2003051365A3 PCT/FR2002/004415 FR0204415W WO03051365A3 WO 2003051365 A3 WO2003051365 A3 WO 2003051365A3 FR 0204415 W FR0204415 W FR 0204415W WO 03051365 A3 WO03051365 A3 WO 03051365A3
Authority
WO
WIPO (PCT)
Prior art keywords
immunosuppressant
compounds
benzamide
family
benzamide family
Prior art date
Application number
PCT/FR2002/004415
Other languages
English (en)
Other versions
WO2003051365A9 (fr
WO2003051365A2 (fr
Inventor
Francois Lang
Delphine Carbonnelle
Jean-Yves Petit
Jean-Michel Robert
Original Assignee
Univ Nantes
Francois Lang
Delphine Carbonnelle
Jean-Yves Petit
Jean-Michel Robert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nantes, Francois Lang, Delphine Carbonnelle, Jean-Yves Petit, Jean-Michel Robert filed Critical Univ Nantes
Priority to AU2002364456A priority Critical patent/AU2002364456A1/en
Publication of WO2003051365A2 publication Critical patent/WO2003051365A2/fr
Publication of WO2003051365A3 publication Critical patent/WO2003051365A3/fr
Publication of WO2003051365A9 publication Critical patent/WO2003051365A9/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L’invention concerne l’utilisation d’un composé de Formule générale (I) pour l’obtention d’un agent immunosuppresseur ciblant les cellules présentatrices d’antigène en inhibant leur action sur les lymphocytes T et plus particulièrement dans le traitement du rejet de greffe ou de la réaction du greffon à l’hôte, le lupus érythémateux disséminé, la sclérodermie, le diabète juvénile insulinodépendant, la polyarthrite rhumatoïde, la maladie de Crohn, le syndrome de Goodpasture, la myasthénie, le rhumatisme articulaire aigu, l’uvéite, la pelade, le vitiligo, l’hépatite auto-immune, la lèpre, l’endocardite aigue, l’hépatite, la tuberculose, la lèpre interpolaire et mycose profonde.
PCT/FR2002/004415 2001-12-19 2002-12-18 Utilisation de composes de la famille des benzamides comme agent immunosuppresseur WO2003051365A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002364456A AU2002364456A1 (en) 2001-12-19 2002-12-18 Use of compounds of the benzamide family as immunosuppressant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR01/16443 2001-12-19
FR0116443A FR2833494B1 (fr) 2001-12-19 2001-12-19 Utilisation de composes de la famille des benzamides comme agent immunosuppresseur

Publications (3)

Publication Number Publication Date
WO2003051365A2 WO2003051365A2 (fr) 2003-06-26
WO2003051365A3 true WO2003051365A3 (fr) 2004-03-04
WO2003051365A9 WO2003051365A9 (fr) 2004-05-06

Family

ID=8870680

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2002/004415 WO2003051365A2 (fr) 2001-12-19 2002-12-18 Utilisation de composes de la famille des benzamides comme agent immunosuppresseur

Country Status (3)

Country Link
AU (1) AU2002364456A1 (fr)
FR (1) FR2833494B1 (fr)
WO (1) WO2003051365A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0254322A1 (fr) * 1986-07-25 1988-01-27 Nisshin Flour Milling Co., Ltd. Dérivés de benzimidazole
EP0632026A1 (fr) * 1993-06-30 1995-01-04 Adir Et Compagnie Nouveaux dérivés d'alpha amino acides leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
EP0684241A1 (fr) * 1994-05-27 1995-11-29 Adir Et Compagnie N-pyridyl carboxamides et dérivés, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0254322A1 (fr) * 1986-07-25 1988-01-27 Nisshin Flour Milling Co., Ltd. Dérivés de benzimidazole
EP0632026A1 (fr) * 1993-06-30 1995-01-04 Adir Et Compagnie Nouveaux dérivés d'alpha amino acides leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
EP0684241A1 (fr) * 1994-05-27 1995-11-29 Adir Et Compagnie N-pyridyl carboxamides et dérivés, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BOBIN-DUBIGEON, CHRISTINE ET AL: "Effects of tumour necrosis factor-.alpha. synthesis inhibitors on rat trinitrobenzene sulphonic acid-induced chronic colitis", EUROPEAN JOURNAL OF PHARMACOLOGY (2001), 431(1), 103-110, XP001086487 *
DEBORD, J. ET AL: "Cholinesterase inhibition by derivatives of 2-amino-4,6- dimethylpyridine", JOURNAL OF ENZYME INHIBITION (1997), 12(1), 13-26, XP008006792 *
DUFLOS M ET AL: "6-Amino-2,4-lutidine carboxamides: alpha-aminoamide derivatives as systemic and topical inflammation inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 33, no. 7-8, 8 July 1998 (1998-07-08), pages 635 - 645, XP004140557, ISSN: 0223-5234 *
LE PAPE, PATRICE ET AL: "Activity of N-lutidinylarylcarboxamides against Leishmania donovani and L. braziliensis", ACTA PARASITOLOGICA (1999), 44(3), 156-159, XP008006794 *
ROBERT J ET AL: "Non-carboxylic antiinflammatory compounds. III. N-(4,6-Dimethylpyridin-2-yl)arylcarboxamides and arylthiocarboxamides acting as brain edema inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 30, no. 12, 1995, pages 915 - 924, XP004040220, ISSN: 0223-5234 *
ROBERT, JEAN MICHEL ET AL: "Synthesis and anti-inflammatory activity of polyazaheterocyclic derivatives of 6-amino-2,4-lutidine and their precursors", ARZNEIMITTEL-FORSCHUNG (1997), 47(5), 635-642, XP001074265 *
VERNHET, LAURENT ET AL: "An anti-inflammatory benzamide derivative inhibits the protein kinase C (PKC)-dependent pathway of Erk2 phosphorylation in murine macrophages", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (1997), 283(1), 358-365, XP008006793 *

Also Published As

Publication number Publication date
FR2833494A1 (fr) 2003-06-20
AU2002364456A8 (en) 2003-06-30
WO2003051365A9 (fr) 2004-05-06
FR2833494B1 (fr) 2006-12-15
WO2003051365A2 (fr) 2003-06-26
AU2002364456A1 (en) 2003-06-30

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