WO2003049788A1 - Procede pour eliminer le vih du sang et dispositif de traitement non pharmacologique du sida - Google Patents

Procede pour eliminer le vih du sang et dispositif de traitement non pharmacologique du sida Download PDF

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Publication number
WO2003049788A1
WO2003049788A1 PCT/CN2002/000507 CN0200507W WO03049788A1 WO 2003049788 A1 WO2003049788 A1 WO 2003049788A1 CN 0200507 W CN0200507 W CN 0200507W WO 03049788 A1 WO03049788 A1 WO 03049788A1
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WIPO (PCT)
Prior art keywords
blood
gas
clip
spiral tube
virus
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PCT/CN2002/000507
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English (en)
French (fr)
Inventor
Gang Pan
Original Assignee
Research Center For Eco-Environmental Sciences, The Chinese Academy Of Sciences
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Publication date
Application filed by Research Center For Eco-Environmental Sciences, The Chinese Academy Of Sciences filed Critical Research Center For Eco-Environmental Sciences, The Chinese Academy Of Sciences
Priority to GB0415050A priority Critical patent/GB2400013B/en
Priority to AU2002313873A priority patent/AU2002313873A1/en
Priority to US10/497,792 priority patent/US7220236B2/en
Publication of WO2003049788A1 publication Critical patent/WO2003049788A1/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/10—Ultraviolet radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
    • A61M2205/051—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy
    • A61M2205/053—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy ultraviolet

Definitions

  • the invention relates to a blood treatment method for eliminating AIDS virus in human blood and a non-drug treatment device for AIDS.
  • the current treatment method is to use drugs to reduce HIV in the blood. These medications, such as
  • “Cocktail” therapy not only needs to be improved, but it is often very expensive. It also has intractable side effects and drug resistance problems. In fact, it is difficult to play a role in patients with general economic ability.
  • commonly used drugs can cause nausea and vomiting, headache, anemia, neutropenia, pancreatitis, and acidosis. Some can cause peripheral neuropathy, diabetes, hepatitis and gastrointestinal symptoms.
  • the purpose of the present invention is to provide a method for eliminating HIV in blood, which is safe and convenient to operate, does not lose blood, and has a selective effect on HIV in blood. Selective killing and other features, and the operating cost is far lower than the current expensive drug treatment methods.
  • Another object of the present invention is to provide a non-drug treatment device for AIDS, which has the characteristics of safe and convenient operation, no blood loss, selective killing of HIV in the blood, etc., and can enable the patient to repeatedly and repeatedly circulate the treatment at any time until Elimination of all viruses in the body, and the operating cost is far lower than the current expensive drug therapy, thus making it possible for most of the low-income AIDS people in the society to receive effective treatment.
  • the present invention provides a method for eliminating HIV in blood, which is characterized in that it includes the following steps:
  • the blood containing virus is input into the input port of the plastic hose, and a gas source is connected to the middle of the plastic hose through which the blood flows, so that the gas of the gas source enters the plastic hose intermittently at a certain frequency, and the The blood in the plastic tube is divided into very small drops of blood;
  • An outlet of the plastic hose is connected to a quartz spiral tube, and a blood source irradiates a blood drop passing through the quartz spiral tube with a radiation source to kill the virus therein.
  • the method for eliminating HIV in blood according to the present invention may have the following additional technical features:
  • the spiral tube may be a disc-type quartz spiral tube, the radiation source is a disc-type ultraviolet lamp, and the disc-type quartz spiral tube is disposed below the disc-type ultraviolet lamp.
  • the middle section of the plastic hose can be clamped in the channel of the multi-channel peristaltic pump.
  • the middle section of the plastic hose is connected to the gas source through a gas delivery hose.
  • a gas input control clip is provided on the gas delivery hose.
  • the gas input control clip may include an upper clip and a lower clip. One end of the upper clip and the lower clip is pivoted together with a pivot, the lower clip is fixed, and the gas delivery hose is provided on the upper clip. Between the upper clamp and the lower clamp, a spring clamp is arranged at the joint of the upper and lower clamps, and a rotating cam for pushing the upper clamp is provided below the other end of the upper clamp.
  • the gas source is a gas chamber filled with sterilized air or a volatile gas that can kill viruses.
  • the method for eliminating HIV in blood is characterized in that: the method for eliminating HIV in blood can be a method of killing HIV by extracorporeal circulation, and an input port of the plastic hose is connected to a virus-infected blood storage bottle, the virus The infected blood storage bottle is connected to a suction blood vessel connected to the patient's body, the healthy blood collection bottle is connected to an infusion bottle, and the infusion bottle is connected to a blood vessel connected to the patient's body.
  • the present invention also provides a non-drug treatment device for AIDS, which is characterized in that it comprises at least one plastic tube, the input port of the plastic tube is connected to a virus-infected blood storage bottle, and the middle section of the plastic tube is clamped in a multi-channel In the channel of the peristaltic pump, the middle section of the plastic hose is connected to a gas source through a gas delivery hose.
  • the gas delivery hose is provided with a gas input control clip.
  • the output of the plastic hose is connected to a spiral tube.
  • the tube is provided on the side of a radiation source, and the spiral tube is connected to a healthy blood collection bottle through a blood delivery tube.
  • the non-drug treatment device for AIDS of the present invention may further have the following additional technical features:
  • the spiral tube may be a quartz spiral tube, the radiation source is an ultraviolet radiation source, and the quartz spiral tube is disposed in a constant temperature box.
  • the spiral tube may also be a disc-type quartz spiral tube, the radiation source is a disc-type ultraviolet lamp, and the disc-type quartz spiral tube is disposed below the disc-type ultraviolet lamp.
  • the spiral tube may also be a ring-shaped quartz spiral tube, the radiation source is a tubular ultraviolet lamp, and the ring-shaped quartz spiral tube is arranged at the periphery of the tubular ultraviolet lamp.
  • the gas input control clip may include an upper clip and a lower clip. One end of the upper clip and the lower clip is pivoted together with a pivot, the lower clip is fixed, and the gas delivery hose is provided on the upper clip. Between the upper clamp and the lower clamp, a spring clamp is arranged at the joint of the upper and lower clamps, and a rotating cam for pushing the upper clamp is provided below the other end of the upper clamp.
  • the non-drug treatment device for AIDS is characterized in that the gas source is A gas chamber filled with sterilized air or a volatile gas that can kill viruses.
  • the non-medicine treatment device for AIDS is characterized in that: the virus-infected blood storage bottle can be connected with a blood draw tube connected to a patient's body.
  • the healthy blood collection bottle is connected to an infusion bottle, and the infusion bottle is connected to a blood vessel connected to a patient's body.
  • the patient's blood can be drawn out, and the closed blood can be used to irradiate the device to eliminate the virus, and then the clean blood can be returned to the original patient.
  • the blood containing the virus is first divided into a large number of tiny microdroplets.
  • a volatile gas drug
  • the drug can effectively kill each small blood droplet. The effect of killing the virus, thereby greatly improving the medicinal properties.
  • a radiation source such as ultraviolet rays
  • Tests have shown that within a certain irradiation dose, when these micro blood droplets are irradiated with a radiation source (such as ultraviolet rays), they can selectively kill the HIV virus in the micro blood droplets, and have other major health-related components in the blood.
  • a radiation source such as ultraviolet rays
  • the effect is small, such as lymphocytes, red blood cells, white blood cells, and hemoglobin in the blood, which do not decrease after irradiation with a certain dose of radiation (such as ultraviolet rays). Therefore, the invention has the characteristics of safe, convenient operation, no blood loss, selective killing of HIV, and the like, and the operation cost is far lower than the current expensive drug treatment methods.
  • the non-drug treatment device for AIDS of the present invention can extract the blood of a patient from one arm, and after the closed extracorporeal circulation, divide the blood containing the virus into a large number of tiny micro blood droplets, and then irradiate with a radiation source (such as ultraviolet rays). It fully acts on these micro blood droplets and efficiently kills the virus in them. After the blood is eliminated, the blood is transported back to the original patient from the other arm, and the operation is safe and convenient.
  • the treatment process can generally be performed without any drugs or chemical reagents, and there are no problems such as dosage, toxic side effects, and drug resistance.
  • the closed type provides safe, convenient, and bloodless operation, which can make patients repeatedly at any time. Repeat the cycle until all the viruses in the body are eliminated. The cost of this method is far lower than the current expensive drug therapies (such as "cocktail” therapy), which makes it possible for people with low incomes who are the majority of patients to receive effective treatment.
  • Tests show that within a certain irradiation dose, when these micro blood droplets are irradiated with a radiation source (such as ultraviolet rays), they can selectively kill the HIV virus in the micro blood droplets, and affect other major health-related components in the blood. Very small, such as lymphocytes, red blood cells, white blood cells, and hemoglobin in the blood, which do not decrease after exposure to radiation sources (such as ultraviolet rays).
  • a radiation source such as ultraviolet rays
  • Fig. 1 is a schematic diagram of a device used in the method for eliminating HIV in the blood according to the present invention.
  • Fig. 2 is a schematic diagram of the present invention for dispersing HIV-containing blood into a large number of minute blood droplets.
  • Fig. 3 is a schematic structural diagram of a preferred embodiment of a non-drug treatment device for AIDS according to the present invention.
  • FIG. 4 is a schematic structural diagram of the gas input control clip in FIG. 3.
  • Fig. 5A is a schematic structural diagram of a disc-type quartz spiral coil and a disc-type ultraviolet lamp of the non-drug treatment device for AIDS according to the present invention.
  • Fig. 5B is a top view of the disc-type quartz spiral tube in Fig. 5A.
  • 6A-6G are graphs showing measurement results of antivirus using the AIDS non-drug treatment device of the present invention.
  • 6A is a case of an HIV viral load and CD4 + lymphocytes in the contrast curve
  • FIG. 6B is a case 2 in HIV viral load and CD4 + lymphocytes in the contrast curve
  • FIG. 6C is a lymphocyte cases 3, 4, 5
  • Figure 6D is the average hemoglobin change curve for cases 3, 4, and 5
  • Figure 6E is the average red blood cell volume change curve for cases 3, 4, and 5
  • Figure 6F is the white blood cell change curve for cases 3, 4, and 5
  • Figure 6G is the red blood cell change curve for cases 3, 4, and 5.
  • the method for eliminating HIV in blood according to the present invention includes the following steps:
  • the blood containing virus is input into the input port of the plastic hose 20, and a middle portion 21 of the plastic hose 20 through which the blood flows is connected to a gas chamber 22 through a gas delivery hose 30, and the gas chamber 22 is filled with sterilized Air or volatile gases that can kill viruses, such as volatile organic solvents, diethyl ether.
  • the gas delivery hose 30 is provided with a gas input control clip 31 that clamps or releases the gas delivery hose 30 at a certain frequency, so that the gas in the gas chamber 22 enters the plastic hose 20 intermittently at a certain frequency.
  • the blood in the plastic tube 20 is divided into small blood drops 10, as shown in FIG. 2.
  • Each tiny blood drop 10 is interrupted by a gas column 11, so that when a radiation source (such as ultraviolet light) is irradiated, these tiny blood drops 10 can fully act on and effectively kill the virus therein.
  • the middle section of the plastic hose 20 is clamped in the channel of the multi-channel peristaltic pump 32.
  • the multi-channel peristaltic pump 32 can be used as a power for unidirectional blood flow and the gas in the gas chamber 22 to enter the plastic hose 20.
  • the output of the plastic hose 20 is connected to a quartz spiral tube 23, and an ultraviolet radiation source 24 is used to irradiate blood drops 10 flowing through the quartz spiral tube 23 to kill the virus therein;
  • the spiral tube may be a disc type
  • the quartz spiral tube 23 ′ may be a disc-type ultraviolet lamp 24 ′, and the disc-type quartz spiral tube 23 ′ is disposed below the disc-type ultraviolet lamp 24 ′, as shown in FIGS. 5A and 5B.
  • the input control clip 31 can be easily designed by those skilled in the art. Can be designed into a variety of different forms.
  • the gas input control clip 31 may include an upper clip 311 and a lower clip 312. One end of the upper clip 311 and the lower clip 312 is pivoted together by a pivot 313.
  • the lower clip 322 is fixed, and the gas delivery hose 30 is disposed between the upper clip 311 and the lower clip 312.
  • a spring clip 314 is provided at the joint of the upper and lower clips 311 and 312, so that the upper and lower clips 311 and 312 can be joined to prevent the gas from passing through.
  • a rotating cam 315 pushing the upper clamp 311 is set under the other end of the upper clamp 311, and the upper clamp 311 can be lifted at a certain frequency to open the clamp to allow gas to pass through.
  • the rotation speed of the rotating cam 315 By controlling the rotation speed of the rotating cam 315, the frequency with which the gas input control clip 31 clamps or releases the gas delivery hose 30 can be controlled.
  • the method for eliminating AIDS virus in the blood according to the present invention may be a method of killing AIDS virus by extracorporeal circulation.
  • the storage bottle 19 is connected to an aspiration tube 18 connected to the patient's body, and the healthy blood collection bottle 27 can be connected to an infusion bottle 28 connected to an infusion tube 29 connected to the patient's body.
  • the non-drug treatment device for AIDS includes two plastic hoses 20, and the input port of the plastic hose 20 is connected to a virus-infected blood storage bottle 19, and the virus-infected blood storage bottle 19 can be connected to one
  • the pumping vessels 18 on one arm of the patient are connected,
  • Multi-channel peristaltic pump 32 distributes blood containing virus (such as HIV) to multiple (two in the figure) plastic hoses 20.
  • the middle section of the plastic hose 20 is clamped in the channel of the multi-channel peristaltic pump 32.
  • the middle section of the plastic hose 20 is further connected to a gas chamber 22 through a gas delivery hose 30.
  • the frequency of the gas input control clip 31 of the gas delivery hose 30 is clamped or released.
  • the moving device utilizes the rotation of the motor in the multi-channel peristaltic pump 32 to control the gas input control clip 31 to close and close at a certain frequency, thereby adding the gas in the gas chamber 22 to the plastic hose 20.
  • the gas in the gas chamber 22 is intermittently entered into the plastic tube 20 at a certain frequency, and the blood in the plastic tube 20 is divided into small blood drops 10, as shown in FIG. 2.
  • Each tiny blood drop 10 is interrupted by a gas column 11, so that when a radiation source (such as ultraviolet rays) is irradiated, these tiny blood drops 10 can fully act on and effectively kill the virus therein.
  • the gas chamber 22 is generally filled with sterilized air, and may be filled with other volatile gases that can kill viruses (such as volatile organic solvent diethyl ether or other drugs).
  • the gas chamber 22 is temperature-controllable.
  • the blood is divided into many small blood droplets by the added gas. These fine blood drops are driven into the thinner quartz spiral tube 23 by the multi-channel peristaltic pump 32, and make uniform circular motion around the ultraviolet radiation source (such as an ultraviolet lamp tube) 24 installed in the quartz spiral tube 23.
  • the lamp tube of the ultraviolet radiation source 24 and the quartz spiral tube 23 surrounding it may be of different shapes (such as in a circular ring or in a convolution) to control the distance and time of the small blood droplets moving in the incubator 25.
  • the intensity of the ultraviolet radiation source 24 is controllable.
  • the quartz spiral tube 23 shown in FIG. 3 is an annular quartz spiral tube, the radiation source 24 is a tubular ultraviolet lamp, and the annular quartz spiral tube is disposed at the periphery of the tubular ultraviolet lamp.
  • the quartz spiral tube may also be a disc-type quartz spiral tube 23 ′
  • the radiation source may be a disc-type ultraviolet lamp 24 ′
  • the disc-shaped quartz spiral tube 23 is disposed in the disc type. UV lamp 24 'below.
  • the intensity and temperature of radiation, and the time that radiation interacts with the virus are controlled by dispersing the blood, thereby increasing the limit and speed of killing viruses (such as HIV) in the blood droplets by radiation.
  • viruses such as HIV
  • the blood is divided into small blood droplets by the volatile gas (drug) that can kill the virus, the drug can more effectively kill the virus on each small blood droplet, thereby greatly improving the drug properties.
  • the blood from which the blood virus has been eliminated flows into the healthy blood collection bottle 27 through the blood delivery tube 26 and can flow into the infusion bottle 28 through the control valve 271.
  • the blood vessel 29 is returned to the patient's other arm.
  • the gas input control clip 31 that clamps or releases the gas delivery hose 30 at a certain frequency can be easily designed by those skilled in the art. It can be designed in various forms.
  • the gas input control clip 31 may include an upper clip 311 and a lower clip 312, and one end of the upper clip 311 and the lower clip 312 is pivoted together by a pivot 313, and the lower clip 322 Fixedly, the gas delivery hose 30 is disposed between the upper clip 311 and the lower clip 312.
  • a spring clip 314 is provided at the joint of the upper and lower clips 311 and 312 to close the upper and lower clips 311 and 312 and prevent the gas from passing through.
  • a rotating cam 315 pushing up the upper clamp 311 is set, and the upper clamp 311 can be lifted at a certain frequency to open the clamp to allow gas to pass through.
  • the rotation speed of the rotating cam 315 By controlling the rotation speed of the rotating cam 315, the frequency at which the gas input control clip 31 clamps or releases the gas delivery hose 30 can be controlled.
  • FIG. 6A-6G are graphs showing the results of anti-virus testing at room temperature using the method for eliminating HIV in the blood and the non-drug treatment device for AIDS shown in Figures 5A and 5B.
  • the radiation intensity of 4,300 microwatts / cm 2 of ultraviolet light (253.7nm).
  • FIG. 6A is a comparison curve of HIV viral load and lymphocyte CD4 in case 1, the abscissa is irradiation time, unit: second; ordinate is HIV viral load, unit: unit / ml; FIG.
  • a patient's virus-containing blood can be drawn out and divided into a large number of tiny micro blood drops, and the virus can be eliminated by a closed extracorporeal circulation with a radiation device. Then, the clean blood is returned to the original patient.
  • a radiation source such as ultraviolet rays
  • the invention has the characteristics of safe, convenient operation, no blood loss, selective killing of HIV, and the like, and the operation cost is far lower than the current expensive drug treatment methods.

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Description

【技术领域】
本发明涉及一种消除人体血液中艾滋病病毒的血液处理方法 及艾滋病的非药物治疗装置。
【背景技术】
目前国际上尚无从根本上防治艾滋病的方法。 目前的治疗方 法， 主要是用药物降低血液中的艾滋病病毒。 这些药物疗法， 如
"鸡尾酒"疗法， 不仅疗效有待提高而且价格往往十分昂贵， 且 有难以克服的强的副作用及抗药性问题， 实际上很难对一般经济 能力的病人发挥作用。 目前常用药物可导致恶心呕吐、 头痛、 贫 血、 中性白细胞减少、 胰腺炎、 酸中毒。 有的还可引发外周神经 病、 糖尿病、 肝炎及消化道症状。
近年来国际上提出一种体外血液治疗技术， 如美国专利第
272535、 068510、 549961 号。 它是将一定体积的艾滋病人的血 液抽到体外， 用挥发性有机溶剂二乙醚处理这些带病毒的血液以 杀死游离或细胞内的艾滋病 （以下简称 HIV) 病毒， 然后将处理 后的血液重新输回到原病人的体内。 这种方法在血液中使用了有 机溶剂， 尽管可以挥发脱离血液， 但难免会对血液中的正常细胞 产生副作用。 而且该方法涉及到对血液的化学处理， 操作复杂， 其实际应用价值有待研究。
【发明内容】
本发明的目的在于提供一种消除血液中艾滋病病毒的方法， 具有操作安全、 方便、 不损失血液、 对血液中的艾滋病毒具有选 择性杀伤等特点， 且运作成本远远低于现行昂贵的药物处理方 法。
本发明的另一目的在于提供一种艾滋病的非药物治疗装置， 具有操作安全、 方便、 不损失血液、 对血液中的艾滋病毒具有选 择性杀伤等特点， 可使病人随时反复多次循环治疗直到消除体内 全部病毒， 且运作成本远远低于现行昂贵的药物疗法， 从而使社 会上大多数收入不高的艾滋病人得到有效治疗成为可能。
为了达到上述目的， 本发明提供一种消除血液中艾滋病病毒 的方法， 其特征在于： 其包括如下步骤：
( 1 ) 将含有病毒的血液输入塑料软管的输入口， 在血液流 经的塑料软管中段连接一气体源， 使该气体源的气体以一定的频 率间断地进入塑料软管中， 而将塑料软管中的血液分割成很小的 血液滴；
( 2 ) 该塑料软管的输出口连接一石英螺旋管， 用辐射源照 射流经该石英螺旋管中的血液滴杀死其中的病毒。
( 3 ) 使经过杀毒的血液流入健康血液收集瓶。
本发明的消除血液中艾滋病病毒的方法， 可以具有如下附加 的技术特征：
该螺旋管可为圆盘型石英螺旋管， 该辐射源为圆盘型紫外 灯， 该圆盘型石英螺旋管设置在该圆盘型紫外灯下方。
该塑料软管中段可被夹持在多通道蠕动泵的通道内， 该塑料 软管中段另通过一气体输送软管连接该气体源， 该气体输送软管 上设置有一气体输入控制夹。
该气体输入控制夹可包括上夹片和下夹片， 该上夹片和下夹 片的一端以枢轴枢设在一起， 该下夹片固定， 该气体输送软管设 在该上夹片和下夹片之间， 上、 下夹片接合处设置一弹簧夹， 上 夹片另一端的下面设一顶推该上夹片的转动凸轮。 该气体源为一气体室， 气体室内充有经消毒的空气或可杀死 病毒的可挥发气体。
所述的消除血液中艾滋病病毒的方法， 其特征在于： 该消除 血液中艾滋病病毒的方法可采用体外循环杀死艾滋病病毒的方 法， 该塑料软管的输入口连接一病毒感染血液储瓶， 病毒感染血 液储瓶与一接在患者身体上的抽血管相连， 该健康血液收集瓶连 接一输液瓶， 该输液瓶连接一接在患者身体上的输血管。
本发明还提供一种艾滋病的非药物治疗装置， 其特征在于： 其包括至少一塑料软管， 该塑料软管的输入口连接病毒感染血液 储瓶， 该塑料软管中段被夹持在多通道蠕动泵的通道内， 该塑料 软管中段另通过一气体输送软管连接一气体源， 该气体输送软管 上设置有一气体输入控制夹， 该塑料软管的输出口连接一螺旋 管， 该螺旋管设在一辐射源一侧， 该螺旋管通过血液输送管连接 健康血液收集瓶。
本发明的艾滋病的非药物治疗装置， 还可以具有如下附加的 技术特征：
该螺旋管可为石英螺旋管， 该辐射源为紫外线辐射源， 且该 石英螺旋管设置在一恒温箱内。
该螺旋管也可为圆盘型石英螺旋管， 该辐射源为圆盘型紫外 灯， 该圆盘型石英螺旋管设置在该圆盘型紫外灯下方。
该螺旋管也可为环状石英螺旋管， 该辐射源为管状紫外灯， 该环状石英螺旋管设置在该管状紫外灯外围。
该气体输入控制夹可包括上夹片和下夹片， 该上夹片和下夹 片的一端以枢轴枢设在一起， 该下夹片固定， 该气体输送软管设 在该上夹片和下夹片之间， 上、 下夹片接合处设置一弹簧夹， 上 夹片另一端的下面设一顶推该上夹片的转动凸轮。
所述的艾滋病的非药物治疗装置， 其特征在于： 该气体源为 一气体室， 气体室内充有经消毒的空气或可杀死病毒的可挥发气 体。
所述的艾滋病的非药物治疗装置， 其特征在于： 该病毒感染 血液储瓶可与一接在患者身体上的抽血管相连。 该健康血液收集 瓶连接一输液瓶， 该输液瓶连接一接在患者身体上的输血管。
本发明的消除血液中艾滋病病毒的方法， 可将病人的血液 抽出， 经过封闭式体外循环以辐射装置消除病毒后， 再将清洁的 血液输回给原病人。 含有病毒的血液首先被分割成大量微小的微 血滴， 当血液被可杀死病毒的可挥发气体 （药物） 分割成小液滴 时， 药物可更有效地对每一颗小血滴发挥杀灭病毒的作用， 从而 大大提高药性。 并且再以辐射源 （如紫外线） 照射这些微血滴， 便可充分地作用于这些微血滴并高效地将其中的病毒杀死。 经试 验表明， 在一定的照射剂量内， 在以辐射源 （如紫外线） 照射这 些微血滴时可以选择性地杀死微血滴中的 HIV 病毒， 而对血液 中其他事关健康的主要成分影响很小， 例如血液中的淋巴细胞、 红细胞、 白细胞及血色素等经一定剂量辐射 （如紫外线） 照射后 基本不下降。 因此， 本发明具有操作安全、 方便、 不损失血液、 对艾滋病毒具有选择性杀伤等特点， 且运作成本远远低于现行昂 贵的药物处理方法。
本发明的艾滋病的非药物治疗装置， 可以将病人的血液从一 个胳膊抽出， 经过封闭式体外循环， 将含有病毒的血液先分割成 大量微小的微血滴， 再以辐射源 （如紫外线） 照射， 充分地作用 于这些微血滴并高效地将其中的病毒杀死， 血液被消除病毒后， 从另一个胳膊输送回给原病人， 操作安全方便。 且治疗过程一般 可以不用任何药物或化学试剂， 不存在用药量、 毒副作用、 及耐 药性等问题， 加之其封闭式所提供的操作安全、 方便、 不失血等 特点， 可使病人随时反复多次循环治疗直到消除体内全部病毒。 该方法的成本远远低于现行昂贵的药物疗法（如 "鸡尾酒"疗法）， 从而使占病人大多数的收入不高的艾滋病人得到有效治疗成为可 能。
试验表明， 在一定的照射剂量内， 在以辐射源 （如紫外线） 照射这些微血滴时可以选择性地杀死微血滴中的 HIV 病毒， 而 对血液中其他事关健康的主要成分影响很小， 例如血液中的淋巴 细胞、 红细胞、 白细胞及血色素等经辐射源 （如紫外线） 照射后 基本不下降。 经实测结果显示， 艾滋病人的血液经上述装置分散 在光强为 4300微瓦 /厘米 2 的紫外光 (253.7nm)照射 90秒后， HIV 病毒载量下降 92%， 而淋巴细胞 （CD4+)、 红细胞、 白细胞及血 色素等基本不下降。
【附图说明】
图 1 是本发明的消除血液中艾滋病病毒的方法所使用的设备 的示意图。
图 2是本发明将含有艾滋病病毒的血液分散成大量微小的微 血滴的示意图。
图 3是本发明的艾滋病的非药物治疗装置的较佳实施例的结 构示意图。
图 4是图 3中的气体输入控制夹的结构示意图。
图 5A 是本发明的艾滋病的非药物治疗装置的圆盘型石英螺 旋管配合圆盘型紫外灯的结构示意图。 图 5B 是图 5A 中的圆盘 型石英螺旋管的俯视图。
图 6A— 6G是显示使用本发明的艾滋病的非药物治疗装置进 行杀毒的测定结果曲线图。 其中图 6A是病例 1的 HIV病毒载量 与淋巴细胞 CD4+的对比曲线； 图 6B是病例 2的 HIV病毒载量 与淋巴细胞 CD4+的对比曲线； 图 6C 是病例 3、 4、 5 的淋巴细 胞数变化曲线； 图 6D是病例 3、 4、 5 的平均血色素变化曲线； 图 6E是病例 3、 4、 5 的平均红细胞体积变化曲线； 图 6F 是病 例 3、 4、 5的白细胞变化曲线； 图 6G是病例 3、 4、 5的红细胞 变化曲线。
【具体实施方式】
参照图 1， 本发明的消除血液中艾滋病病毒的方法， 包括如 下步骤：
( 1 ) 将含有病毒的血液输入塑料软管 20的输入口， 在血液 流经的塑料软管 20的中段 21通过一气体输送软管 30连接一气 体室 22， 气体室 22 内充有经消毒的空气或可杀死病毒的可挥发 气体， 如挥发性有机溶剂二乙醚。 该气体输送软管 30 上设置有 一以一定的频率夹紧或放开该气体输送软管 30 的气体输入控制 夹 31， 使该气体室 22 的气体以一定的频率间断地进入塑料软管 20中， 从而将塑料软管 20中的血液分割成很小的血液滴 10， 如 图 2所示。 每个微小的血液滴 10之间都被气体柱 11隔断， 从而 使辐射源 （如紫外线） 照射时， 可充分地作用于这些微小的血液 滴 10并高效地将其中的病毒杀死。 该塑料软管 20中段被夹持在 多通道蠕动泵 32的通道内， 多通道蠕动泵 32可作为血液单向流 动及使气体室 22中的气体进入塑料软管 20的动力。
( 2 ) 该塑料软管 20 的输出口连接一石英螺旋管 23， 用紫 外线辐射源 24照射流经该石英螺旋管 23 中的血液滴 10杀死其 中的病毒； 该螺旋管可为圆盘型石英螺旋管 23 '， 该辐射源可为 圆盘型紫外灯 24 '， 该圆盘型石英螺旋管 23 ' 设置在该圆盘型紫 外灯 24 ' 下方， 如图 5A、 5B所示。 通过控制紫外线辐射源 24 的辐射强度及恒温箱 25 的温度， 及辐射与分散血滴作用的时间 可控制血滴中 HIV病毒被紫外线辐射杀死的限度和速度。
( 3 ) 使经过杀毒的血液流入健康血液收集瓶 27。
上述的以一定的频率夹紧或放开该气体输送软管 30 的气体 输入控制夹 31 对于本领域的技术人员可以轻易地设计出来。 可 以设计成各种不同的形式。 .例如如图 4所示， 该气体输入控制夹 31可以包括上夹片 311和下夹片 312，该上夹片 311和下夹片 312 的一端以枢轴 313枢设在一起， 下夹片 322固定， 该气体输送软 管 30设在该上夹片 311和下夹片 312之间。上、下夹片 311、 312 接合处设一弹簧夹 314可使上、 下夹片 311、 312接合， 阻止气 体通过。 上夹片 311另一端的下面设一顶推该上夹片 311的转动 凸轮 315， 可将上夹片 311 按一定频率抬起， 以打开夹片让气体 通过。通过控制转动凸轮 315的转速即可控制气体输入控制夹 31 夹紧或放开该气体输送软管 30的频率。
本发明的消除血液中艾滋病病毒的方法， 可以采用体外循环 杀死艾滋病病毒的方法， 例如如图 3所示， 该塑料软管 20 的输 入口可连接一病毒感染血液储瓶 19， 病毒感染血液储瓶 19与一 接在患者身体上的抽血管 18相连， 该健康血液收集瓶 27可连接 一输液瓶 28， 该输液瓶连接一接在患者身体上的输血管 29。
参照图 3， 本发明的艾滋病的非药物治疗装置， 包括两根塑 料软管 20， 该塑料软管 20的输入口连接病毒感染血液储瓶 19， 该病毒感染血液储瓶 19可与一接在患者一只胳膊上的抽血管 18 相连，
首先将受病毒 （如 HIV) 感染的血液通过减压泵 17 从病人 的一只胳膊抽经抽血管 18送到病毒感染血液储瓶 19中。 然后通 过阔门 16调节病毒感染血液储瓶 19中的压力为常压。 通过多通 道蠕动泵 32将含病毒 （如 HIV) 的血液分送到多根 （图中为两 根） 塑料软管 20中。 该塑料软管 20中段被夹持在多通道蠕动泵 32 的通道内， 该塑料软管 20 中段另通过一气体输送软管 30连 接一气体室 22， 该气体输送软管 30上设置有一以一定的频率夹 紧或放开该气体输送软管 30的气体输入控制夹 31， 可以通过传 动装置 （图未示） 利用多通道蠕动泵 32 中马达的转动控制气体 输入控制夹 31 以一定的频率一闭一合， 从而将气体室 22中的气 体加入到塑料软管 20中。 使该气体室 22的气体以一定的频率间 断地进入塑料软管 20中， 而将塑料软管 20中的血液分割成很小 的血液滴 10， 如图 2所示。 每个微小的血液滴 10之间都被气体 柱 11 隔断， 从而使辐射源 （如紫外线） 照射时， 可充分地作用 于这些微小的血液滴 10并高效地将其中的病毒杀死。 气体室 22 一般装消毒空气， 也可装其他可杀死病毒的可挥发气体 （如挥发 性有机溶剂二乙醚或其它药物）。 气体室 22可控温。 血液被所加 气体分割成许多细小血液滴。 这些细小的血液滴在多通道蠕动泵 32的驱使下进入更细的石英螺旋管 23 中， 并围绕安装在石英螺 旋管 23内的紫外线辐射源 （如紫外灯管） 24做均匀的圆周运动。 紫外线辐射源 24的灯管及围绕其外的石英螺旋管 23可以是不同 形状 （如圆环形或回旋中） 以控制小血滴在恒温箱 25 中所运动 的距离和时间。 紫外线辐射源 24的光强是可控的。 如图 3 所示 的石英螺旋管 23为环状石英螺旋管，该辐射源 24为管状紫外灯， 该环状石英螺旋管设置在该管状紫外灯外围。
参照图 5A、 5B， 该石英螺旋管也可以采用圆盘型石英螺旋 管 23 '， 该辐射源可以采用圆盘型紫外灯 24 '， 该圆盘型石英螺 旋管 23， 设置在该圆盘型紫外灯 24 ' 下方。
这样通过分散血液， 控制辐射强度、 温度、 及辐射与病毒作 用的时间从而提高血滴中病毒 （如 HIV) 被辐射杀死的限度和速 度。 当血液被可杀死病毒的可挥发气体 （药物） 分割成小血液滴 时， 药物可更有效地对每一颗小血滴发挥杀灭病毒的作用， 从而 大大提高药性。 消除了血液病毒的血液通过血液输送管 26 流入 健康血液收集瓶 27中， 并可通过控制阀 271流入输液瓶 28中。 通过调节输液瓶' 28上的气压泵 281 的压力， 可将健康血液经输 血管 29输回到病人的另一只胳膊中。
上述的以一定的频率夹紧或放开该气体输送软管 30 的气体 输入控制夹 31 对于本领域的技术人员可以轻易地设计出来。 可 以设计成各种不同的形式。 例如如图 4所示， 该气体输入控制夹 31可以包括上夹片 311和下夹片 312，该上夹片 311和下夹片 312 的一端以枢轴 313枢设在一起， 下夹片 322固定， 该气体输送软 管 30设在该上夹片 311和下夹片 312之间。上、下夹片 311、 312 接合处设一弹簧夹 314可使上， 下夹片 311、 312 闭合， 阻止气 体通过。 上夹片 311另一端的下面设一顶推该上夹片 311的转动 凸轮 315， 可将上夹片 311 按一定频率抬起， 以打开夹片让气体 通过。通过控制转动凸轮 315的转速即可控制气体输入控制夹 31 夹紧或放开该气体输送软管 30的频率。
图 6A— 6G 是显示使用本发明的消除血液中艾滋病病毒的方 法及图 5A、 5B所示的艾滋病的非药物治疗装置， 在室温下进行 杀毒的测示结果曲线图。 其中辐射的光强为 4300微瓦 /厘米 2 的 紫外光 (253.7nm)。 图 6A是病例 1 的 HIV病毒载量与淋巴细胞 CD4的对比曲线， 横坐标为照射时间， 单位： 秒； 纵坐标为 HIV 病毒载量， 单位： 个 /毫升； 图 6B是病例 2 的 HIV病毒载量与 淋巴细胞 CD4 的对比曲线； 横坐标为照射时间， 单位： 秒； 纵 坐标为 HIV 病毒载量， 单位： 个 /毫升； 图 6C 是病例 3、 4、 5 的淋巴细胞数变化曲线； 横坐标为照射时间， 单位： 秒； 纵坐标 为淋巴细胞数； 图 6D是病例 3、 4、 5 的平均血色素变化曲线； 横坐标为照射时间，单位：秒；纵坐标为平均血色素，单位： g/L ； 图 6E是病例 3、 4、 5 的平均红细胞体积变化曲线； 横坐标为照 射吋间， 单位： 秒； 纵坐标为平均红细胞体积， 单位： fL ； 图 6F 是病例 3、 4、 5 的白细胞变化曲线； 横坐标为照射时间， 单 位： 秒； 纵坐标为白细胞数， 单位： 10E9/L; 图 6G是病例 3、 4、 5 的红细胞变化曲线， 横坐标为照射时间， 单位： 秒； 纵坐标为 红细胞数， 单位： 10E12/L。
实测结果显示， 艾滋病人的血液经上述装置分散在光强为 4300微瓦 /厘米 2 的紫外光 (253.7nm)照射 90秒后， 病例 1、 2的 HIV病毒载量 HIV病毒载量下降 92%, 而淋巴细胞 （CD4+)、 红 细胞、 白细胞及血色素等基本不下降。 如图 6A— 6G所示。
【工业应用性】
采用本发明提出的消除血液中艾滋病病毒的方法及非药物 治疗装置， 可将病人的含有病毒的血液抽出并将其分割成大量微 小的微血滴， 经过封闭式体外循环以辐射装置消除病毒后， 再将 清洁的血液输回给原病人。在一定的照射剂量内，在以辐射源（如 紫外线） 照射这些微血滴时可以选择性地杀死微血滴中的 HIV 病毒， 而对血液中其他事关健康的主要成分影响很小。 因此， 本 发明具有操作安全、 方便、 不损失血液、 对艾滋病毒具有选择性 杀伤等特点， 且运作成本远远低于现行昂贵的药物处理方法。

Claims

权 利 要 求
1、 一种消除血液中艾滋病病毒的方法， 其特征在于： 其包 括如下步骤：
( 1 ) 将含有病毒的血液输入塑料软管的输入口， 在血液流 经的塑料软管中段连接一气体源， 使该气体源的气体以一定的频 率间断地进入塑料软管中， 而将塑料软管中的血液分割成很小的 血液滴；
( 2 ) 该塑料软管的输出口连接一石英螺旋管， 用辐射源照 射流经该石英螺旋管中的血液滴杀死其中的病毒；
( 3 ) 使经过杀毒的血液流入健康血液收集瓶。
2、 根据权利要求 1 所述的消除血液中艾滋病病毒的方法， 其特征在于： 该螺旋管为圆盘型石英螺旋管， 该辐射源为圆盘型 紫外灯， 该圆盘型石英螺旋管设置在该圆盘型紫外灯下方。
3、 根据权利要求 2 所述的消除血液中艾滋病病毒的方法， 其特征在于： 该塑料软管中段被夹持在多通道蠕动泵的通道内， 该塑料软管的一端通过一气体输送软管连接气体源， 该气体输送 软管上设置有一气体输入控制夹。
4、 根据权利要求 3 所述的消除血液中艾滋病病毒的方法， 其特征在于： 该气体输入控制夹包括上夹片和下夹片， 该上夹片 和下夹片的一端以枢轴枢设在一起， 该下夹片固定， 该气体输送 软管设在该上夹片和下夹片之间， 上、 下夹片接合处设置一弹簧 夹， 上夹片另一端的下面设一顶推该上夹片的转动凸轮。
5、 根据权利要求 1 所述的消除血液中艾滋病病毒的方法， 其特征在于： 该气体源为一气体室， 气体室内充有经消毒的空气 或可杀死病毒的可挥发气体。
6、 根据权利要求 3或 4或 5所述的消除血液中艾滋病病毒 的方法， 其特征在于： 该消除血液中艾滋病病毒的方法是采用体 外血液循环杀死艾滋病病毒的方法， 该塑料软管的输入口连接一 病毒感染血液储瓶， 病毒感染血液储瓶与一接在患者身体上的抽 血管相连， 该健康血液收集瓶连接一输液瓶， 该输液瓶连接一接 在患者身体上的输血管。
7、 一种艾滋病的非药物治疗装置， 其特征在于： 其包括至 少一塑料软管， 该塑料软管的输入口连接病毒感染血液储瓶， 该 塑料软管中段被夹持在多通道蠕动泵的通道内， 该塑料软管的一 端通过一气体输送软管连接一气体源， 该气体输送软管上设置有 一气体输入控制夹， 该塑料软管的输出口连接一螺旋管， 该螺旋 管设在一辐射源一侧， 该螺旋管通过血液输送管连接健康血液收 集瓶。
8、 根据权利要求 7 所述的艾滋病的非药物治疗装置， 其特 征在于： 该螺旋管为石英螺旋管， 该辐射源为紫外线辐射源， 且 该石英螺旋管与该辐射源设置在一恒温箱内。
9、 根据权利要求 7 所述的艾滋病的非药物治疗装置， 其特 征在于： 该螺旋管为圆盘型石英螺旋管， 该辐射源为圆盘型紫外 灯， 该圆盘型石英螺旋管设置在该圆盘型紫外灯下方。
10、 根据权利要求 7所述的艾滋病的非药物治疗装置， 其特 征在于： 该螺旋管为环状石英螺旋管， 该辐射源为管状紫外灯， 该环状石英螺旋管设置在该管状紫外灯外围。
1 1、 根据权利要求 9或 10所述的艾滋病的非药物治疗装置， 其特征在于： 该气体输入控制夹包括上夹片和下夹片， 该上夹片和下夹片 的一端以枢轴枢设在一起， 该下夹片固定， 该气体输送软管设在 该上夹片和下夹片之间， 上、 下夹片接合处设置一弹簧夹， 上夹 片另一端的下面设一顶推该上夹片的转动凸轮。
12、 根据权利要求 11 所述的艾滋病的非药物治疗装置， 其 特征在于： 该气体源为一气体室， 气体室内充有经消毒的空气或 可杀死病毒的可挥发气体。
13、 根据权利要求 12 所述的艾滋病的非药物治疗装置， 其 特征在于： 该病毒感染血液储瓶与一接在患者身体上的抽血管相 连， 该健康血液收集瓶连接一输液瓶， 该输液瓶连接一接在患者 身体上的输血管。
PCT/CN2002/000507 2001-12-10 2002-07-19 Procede pour eliminer le vih du sang et dispositif de traitement non pharmacologique du sida WO2003049788A1 (fr)

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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1308045C (zh) 2001-12-10 2007-04-04 中国科学院生态环境研究中心 艾滋病的非药物治疗装置
US7291269B2 (en) * 2003-03-17 2007-11-06 Gambro Lundia Ab Apparatus and process for extracorporeal treatment of blood with selective extraction of solutes
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
CA2737461A1 (en) 2008-09-19 2010-03-25 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
US20110152770A1 (en) 2009-07-30 2011-06-23 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
CN103861164A (zh) * 2012-12-15 2014-06-18 钱捷 一种紫外线照射血疗仪
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
CN106267409B (zh) * 2016-07-01 2019-02-01 翁炳焕 艾滋病生物治疗反应器
CN113476679A (zh) * 2021-05-28 2021-10-08 云南省肿瘤医院(昆明医科大学第三附属医院) 一种用于妇科阴道灌洗清洁的设备

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5389335A (en) * 1993-06-18 1995-02-14 Charm Sciences, Inc. High temperature, short time microwave heating system and method of heating heat-sensitive material
JPH08155026A (ja) * 1992-09-10 1996-06-18 Yoshimasa Sudo エイズ治療用血液浄化器
WO1996028198A1 (en) * 1995-03-13 1996-09-19 Ao Forschungsinstitut Davos An extracorporeal blood treatment apparatus and method for removal of free circulating infectious agents
JP2000300664A (ja) * 1999-04-23 2000-10-31 Eruson Kk 体外血液処理装置

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484396A (en) * 1988-11-17 1996-01-16 Naficy; Sadeque S. Method and device for treatment of HIV infections and AIDS
US5419759A (en) * 1988-11-17 1995-05-30 Naficy; Sadeque S. Apparatus and methods for treatment of HIV infections and AIDS
US5116307A (en) * 1990-07-09 1992-05-26 Collins Harvey T Method and system for treatment of AIDS
CN2206635Y (zh) * 1994-05-07 1995-09-06 高良恕 封闭式紫外线辐射血液回输装置
GB9502347D0 (en) * 1995-02-07 1995-03-29 Ca Nat Research Council Method and apparatus for inactivation of viruses in body fluids
CA2275467C (en) * 1999-06-18 2004-03-02 Biophys Inc. Method and apparatus for flowing sterile fluid membranes
JP4864236B2 (ja) * 2001-06-27 2012-02-01 株式会社フジ医療器 マット型エアーマッサージ装置
CN1308045C (zh) 2001-12-10 2007-04-04 中国科学院生态环境研究中心 艾滋病的非药物治疗装置

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08155026A (ja) * 1992-09-10 1996-06-18 Yoshimasa Sudo エイズ治療用血液浄化器
US5389335A (en) * 1993-06-18 1995-02-14 Charm Sciences, Inc. High temperature, short time microwave heating system and method of heating heat-sensitive material
WO1996028198A1 (en) * 1995-03-13 1996-09-19 Ao Forschungsinstitut Davos An extracorporeal blood treatment apparatus and method for removal of free circulating infectious agents
JP2000300664A (ja) * 1999-04-23 2000-10-31 Eruson Kk 体外血液処理装置

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AU2002313873A1 (en) 2003-06-23
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US7220236B2 (en) 2007-05-22

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