JP2016083370A - 単核細胞の採集のための方法とシステム - Google Patents
単核細胞の採集のための方法とシステム Download PDFInfo
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Abstract
Description
Claims (22)
- a)赤血球、血漿と血小板を含む生物学的流体から単核細胞を分離すること、
b)血漿と残留赤血球と血小板とを含む懸濁液中の標的とする数の単核細胞を採集すること、
c)分離した単核細胞を濃縮すること、
d)濃縮された単核細胞内に残る残留血漿の量が予め決定された体積に到達するまで濃縮した単核細胞から血漿を除去すること、そして、
e)濃縮された単核細胞に晶質液を添加すること
を含む、分離装置を用いて単核細胞を得て単核細胞を循環光療法のために調整するための方法。 - 前記濃縮された単核細胞内に残る残留血漿の体積は、50mL以下である、請求項1に記載の方法。
- 前記濃縮された単核細胞は、晶質液の添加後、2%以下のヘマトクリットを有する、請求項1または請求項2に記載の方法。
- 晶質液は、血漿の体積%が25%以下になるように前記濃縮された単核細胞に添加される、請求項1から請求項3までのいずれか1項に記載の方法。
- 晶質液は前記懸濁液に150mLから200mLの量、添加される、請求項1から請求項4までのいずれか1項に記載の方法。
- さらに前記単核細胞を、単核細胞の照射に適した採集容器内に採集することを含む、請求項1から請求項5までのいずれか1項に記載の方法。
- 処理器具の1以上の室内で前記単核細胞を分離し濃縮することを含む、請求項1から請求項6までのいずれか1項に記載の方法。
- 前記処理器具を、前記単核細胞を分離し濃縮するために十分な遠心場に曝すことを含む、請求項7に記載の方法。
- 前記生物学的流体は全血を含む、請求項1から請求項8までのいずれか1項に記載の方法。
- 前記懸濁液は、前記分離装置を洗浄することによって分離装置から回収された量の単核細胞を含む、請求項1から請求項9までのいずれか1項に記載の方法。
- 前記分離装置は晶質液で洗浄される、請求項10に記載の方法。
- 前記分離装置は血漿で洗浄される、請求項10に記載の方法。
- 前記分離装置は10mLの晶質液で洗浄される、請求項11に記載の方法。
- 前記分離装置は10mLの血漿で洗浄される、請求項12に記載の方法。
- a)分離装置と、生物学的流体の処理に対する指示を含むプログラム可能なマイクロプロセッサで駆動される制御部とを含む再使用可能なハードウェア器具と、
b)前記回路は生物学的流体を受容するための処理室と単核細胞を採集するための1以上の容器とを含む、器具に接続された使い捨て可能な処理回路と、
c)制御部であって、
i)赤血球、血漿そして血小板を含む生物学的流体から単核細胞を分離し、
ii)単核細胞を濃縮し、濃縮された単核細胞内に残る血漿残量が予め定められた体積に到達するまで血漿を除去し、
iii)濃縮された単核細胞と晶質液を組み合わせるようにプログラムされた制御部と
を備える、単核細胞を採集するためのシステム。 - 前記分離装置は回転可能な要素を備える、請求項15に記載のシステム。
- 前記回転可能な要素は、単核細胞を生物学的流体の他の成分から分離するために十分な遠心場を生成する、請求項15または請求項16に記載のシステム。
- さらに晶質液源を備える、請求項15に記載のシステム。
- 前記制御部は、選択された体積の前記晶質液を、前記残留量の血漿中の濃縮された単核細胞に送達するようにプログラムされている、請求項15から請求項18までのいずれか1項に記載のシステム。
- 単核細胞、血漿、晶質液、そして残留赤血球と血小板とを含み、全体積で200mLであり、ヘマトクリットが2%以下である、単核細胞生成物。
- 血漿の体積%は25%以下である、請求項20に記載の単核細胞生成物。
- 濃縮された単核細胞とともに残る残留血漿の体積は50mL以下である、請求項20または請求項21に記載の単核細胞生成物。
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US10434240B2 (en) * | 2015-08-17 | 2019-10-08 | Fenwal, Inc. | Methods and systems for processing and washing a photopheresis mononuclear cell product |
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US11285250B2 (en) | 2017-03-07 | 2022-03-29 | Fenwal, Inc. | Systems and methods for separating blood under conditions of reduced plasma clarity |
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