WO2003045994A1 - Nouveau ligand et adn de ce ligand - Google Patents

Nouveau ligand et adn de ce ligand Download PDF

Info

Publication number
WO2003045994A1
WO2003045994A1 PCT/JP2002/012263 JP0212263W WO03045994A1 WO 2003045994 A1 WO2003045994 A1 WO 2003045994A1 JP 0212263 W JP0212263 W JP 0212263W WO 03045994 A1 WO03045994 A1 WO 03045994A1
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
dna
novel ligand
acid sequence
same
Prior art date
Application number
PCT/JP2002/012263
Other languages
English (en)
Japanese (ja)
Inventor
Shuji Hinuma
Ryo Fujii
Shoji Fukusumi
Masaaki Mori
Hiromi Yoshida
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Priority to AU2002349474A priority Critical patent/AU2002349474A1/en
Publication of WO2003045994A1 publication Critical patent/WO2003045994A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Cette invention se rapporte à un ligand GPR7 ayant une séquence d'acides aminés qui est identique ou pratiquement identique à la séquence d'acides aminés représentée par le numéro d'identification de séquence 1 portant un résidu d'acide aminé halogéné à l'extrémité N, ce ligand étant utile pour la mise au point d'un système de dosage de fixation de récepteurs au moyen d'un système d'expression de GPR7 et pour le criblage d'un composé candidat pour un médicament tel qu'un agent contre l'obésité, notamment.
PCT/JP2002/012263 2001-11-26 2002-11-25 Nouveau ligand et adn de ce ligand WO2003045994A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002349474A AU2002349474A1 (en) 2001-11-26 2002-11-25 Novel ligand and dna thereof

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2001359826 2001-11-26
JP2001-359826 2001-11-26
JP2001401019 2001-12-28
JP2001-401019 2001-12-28
JP2002154570 2002-05-28
JP2002-154570 2002-05-28

Publications (1)

Publication Number Publication Date
WO2003045994A1 true WO2003045994A1 (fr) 2003-06-05

Family

ID=27347871

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/012263 WO2003045994A1 (fr) 2001-11-26 2002-11-25 Nouveau ligand et adn de ce ligand

Country Status (2)

Country Link
AU (1) AU2002349474A1 (fr)
WO (1) WO2003045994A1 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044368A1 (fr) * 2000-11-30 2002-06-06 Takeda Chemical Industries, Ltd. Nouvelles proteines du recepteur couple a la proteine g et leurs adn

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044368A1 (fr) * 2000-11-30 2002-06-06 Takeda Chemical Industries, Ltd. Nouvelles proteines du recepteur couple a la proteine g et leurs adn

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FUJII R. ET AL.: "Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7", J. BIOL. CHEM., vol. 277, no. 37, 13 September 2002 (2002-09-13), pages 34010 - 34016, XP002212837 *
SHIMOMURA Y. ET AL.: "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8", J. BIOL. CHEM., vol. 277, no. 39, 27 September 2002 (2002-09-27), pages 35826 - 35832, XP002961094 *

Also Published As

Publication number Publication date
AU2002349474A1 (en) 2003-06-10

Similar Documents

Publication Publication Date Title
IL163066A (en) Ligands for the zcytor17 receptor
WO2003020932A1 (fr) Nouvelles proteines de secretion et adn associe
CA2345024A1 (fr) Proteines modifiees de la superfamille du tgf-.beta.
CA2248140A1 (fr) Analyses et reactifs permettant de quantifier le hbnp
WO2002084286A1 (fr) Procede de criblage
IL135687A0 (en) A novel human checkpoint kinase, hcds1, compositions and methods
DK1064376T3 (da) GFR-alpha3 og dets anvendelser
AU2126400A (en) Detection of small molecules by use of a piezoelectric sensor
CA2361987A1 (fr) Proteine de liaison a l'antigene du syndrome de goodpasture
WO2002102847A1 (fr) Nouveau ligand et son adn
EP1182458A4 (fr) Methode de detection de proteines en interaction mutuelle
BR9815788B1 (pt) proteÍna quimÉrica.
WO2001064713A3 (fr) Variants du recepteur d'interleukine-10 (il-10) des mammiferes
WO1998032858A3 (fr) Chemokines de mammiferes, recepteurs, reactifs, et modes d'utilisation
WO2003002730A3 (fr) Methode de detection de l'activite de la calpaine 3 dans un echantillon biologique et peptides pour la mise en oeuvre de ladite methode
WO2005100386A3 (fr) Récepteur de canine sensible au froid et au menthol 1
WO2003045994A1 (fr) Nouveau ligand et adn de ce ligand
WO2002042458A3 (fr) Nouveaux recepteurs
WO2002000719A3 (fr) Nouveaux recepteurs
WO1998031810A3 (fr) Chemokines de mammiferes, recepteurs, reactifs, utilisations
WO2003021262A1 (fr) Procede de criblage
AU5569600A (en) Novel protein and dna thereof
DK1071779T3 (da) Patched-2-protein fra hvirveldyr
WO2003004678A3 (fr) Nouveaux recepteurs
EP0854186A3 (fr) Gène de division cellulaire DivIB de Staphylococcus aureus

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP