WO2003045994A1 - Novel ligand and dna thereof - Google Patents

Novel ligand and dna thereof Download PDF

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Publication number
WO2003045994A1
WO2003045994A1 PCT/JP2002/012263 JP0212263W WO03045994A1 WO 2003045994 A1 WO2003045994 A1 WO 2003045994A1 JP 0212263 W JP0212263 W JP 0212263W WO 03045994 A1 WO03045994 A1 WO 03045994A1
Authority
WO
WIPO (PCT)
Prior art keywords
amino acid
dna
novel ligand
acid sequence
same
Prior art date
Application number
PCT/JP2002/012263
Other languages
French (fr)
Japanese (ja)
Inventor
Shuji Hinuma
Ryo Fujii
Shoji Fukusumi
Masaaki Mori
Hiromi Yoshida
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Priority to AU2002349474A priority Critical patent/AU2002349474A1/en
Publication of WO2003045994A1 publication Critical patent/WO2003045994A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A GPR7 ligand having an amino acid sequence, which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO:1 carrying a halogenated amino acid residue at the N-end, is useful in developing a receptor binding assay system with the use of a GPR7 expression system, screening a candidate compound for a drug such as an antiobestic, etc.
PCT/JP2002/012263 2001-11-26 2002-11-25 Novel ligand and dna thereof WO2003045994A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002349474A AU2002349474A1 (en) 2001-11-26 2002-11-25 Novel ligand and dna thereof

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2001359826 2001-11-26
JP2001-359826 2001-11-26
JP2001-401019 2001-12-28
JP2001401019 2001-12-28
JP2002154570 2002-05-28
JP2002-154570 2002-05-28

Publications (1)

Publication Number Publication Date
WO2003045994A1 true WO2003045994A1 (en) 2003-06-05

Family

ID=27347871

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/012263 WO2003045994A1 (en) 2001-11-26 2002-11-25 Novel ligand and dna thereof

Country Status (2)

Country Link
AU (1) AU2002349474A1 (en)
WO (1) WO2003045994A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044368A1 (en) * 2000-11-30 2002-06-06 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor proteins and dnas thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044368A1 (en) * 2000-11-30 2002-06-06 Takeda Chemical Industries, Ltd. Novel g protein-coupled receptor proteins and dnas thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FUJII R. ET AL.: "Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7", J. BIOL. CHEM., vol. 277, no. 37, 13 September 2002 (2002-09-13), pages 34010 - 34016, XP002212837 *
SHIMOMURA Y. ET AL.: "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8", J. BIOL. CHEM., vol. 277, no. 39, 27 September 2002 (2002-09-27), pages 35826 - 35832, XP002961094 *

Also Published As

Publication number Publication date
AU2002349474A1 (en) 2003-06-10

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