WO2003045349A2

WO2003045349A2 - Itch-relieving cosmetic and dermatological preparations

Info

Publication number: WO2003045349A2
Application number: PCT/EP2002/013033
Authority: WO
Inventors: Alexder Filbry; Rainer Kröpke; Dagmar Zelle
Original assignee: Beiersdorf Ag
Priority date: 2001-11-27
Filing date: 2002-11-21
Publication date: 2003-06-05
Also published as: DE10158199A1; US20030147928A1; WO2003045349A3; EP1450760B1; ATE356606T1; ES2282502T3; US20090110649A1; DE50209739D1; US20050002974A1; EP1450760A2; JP2005511637A

Abstract

The invention relates to itch-relieving cosmetic and dermatological preparations containing one or more O/W emulsifiers, optionally one or more co-emulsifiers, polidocanol and ethereal oil. Application of the inventive preparation provides immediate and long lasting itch relief.

Description

description

Anti-itch cosmetic and dermatological preparations

The present invention relates to antipruritic cosmetic and dermatological preparations which contain polidocanol and essential oil. An immediate and long-lasting itching reduction is found when using the preparation according to the invention.

Itching (itchy skin, pruritus) is a subjectively annoying and unpleasant sensation related to the skin or mucous membrane. It can be localized or it can occur over the whole body. Itching can be burning, stinging or tingling and almost always leads to rubbing or scratching. This in turn can cause skin symptoms such as scratch marks, open wounds, crusts, skin infections. The itching sensation is perceived via pain receptors on the skin and sent to the brain via the autonomic nervous system. The cause of the itching is often diverse and can sometimes be the first and only symptom in skin diseases or general diseases. In addition to dry skin, lack of moisture and clothing, itching can also result from external influences and skin irritation, such as bites from mosquitoes or after contact with nettles or agony. Itching can be a reaction to chemical, mechanical or thermal stimuli. As a result of external irritation, such as the effects of chemical substances such as histamine (mosquito bite), apamine (bee sting), allergic immune reactions, pressure or friction or even heat or sun exposure, wheals, urticaria and other skin reactions associated with itching are caused. The so-called senile pruritus is also known and essential, which often leads to unpleasant side effects in older people. In the treatment of pruritus, in addition to the diagnosis of the cause, the focus is primarily on measures to reduce or relieve itching. This often happens regardless of the influence on the underlying disease.

The known medications or relievers for itching are administered in tablet form or in the form of powder, ointments, gels or emulsions. While tablets lead to a systemic effect that puts a strain on the entire organism, a specific formulation is necessary for gels, creams and emulsions in order to keep the active ingredient permanently and consistently and, above all, effective in the preparation.

There are numerous tried and tested remedies for itching. For example, cooling gels and sticks are mainly used, which contain antihistamines in addition to cooling by evaporating alcohol or water. Isoprenaline is also used, but this is not recommended due to the known skin irritation.

A well-known cream is, for example, Camillen 60 FUDES. The cream based on petroleum jelly, calendula oil and menthol to relieve itching. Additives such as antibacterial substances, benzoic acid and triclosan provide preventive protection against fungal attack.

The pain relieving gel Thesit® sold by Desitin contains the components polidocanol, mepivacaine hydrochloride and benzalkonium chloride. The gel is intended for the treatment of skin injuries, burns and itching, with mepivacaine hydrochloride acting as a local anesthetic.

DE 19833177 describes the use of a plaster with the active ingredients menthol and benzocaine, as a local anesthetic, for reducing irritation in the case of insect bites and contact with nettle. It is disadvantageous that local anesthetics are able to trigger contact allergies and the addition of local anesthetics renders the subsequent distribution as a cosmetic inadmissible.

The object of the present invention is to provide a preparation which is long-lasting itch-relieving or itch-relieving, enriches the state of the art and an alternative to the previously known itch-relieving Preparations offers. Another object is to provide an itch-relieving preparation which does not have the disadvantages of the preparations from the prior art and in particular has an immediate and long-lasting antipruritic action without the need to add an excessive amount of antipruritic active ingredients. Another task is to provide an itch-relieving preparation that has a nourishing effect and can be applied in a user-friendly manner. It must normalize the moisturizing and moisture regulation of the skin and also protect it from skin damage caused by sun exposure. Especially in countries with high sun exposure there is usually a risk of insect bites and / or jellyfish contact.

The stated tasks are solved by preparations according to the main claim. The subclaims relate to advantageous embodiments of the preparations according to the invention. The invention further comprises the use of such preparations.

It was surprising and unforeseeable for the person skilled in the art that a preparation containing one or more O / W emulsifiers, optionally one or more coemulsifiers, polidocanol and essential oil, accomplishes the tasks set.

In particular, the active ingredients polidocanol and menthol in nonionic emulsion bases, in particular in emulsions based on eumulgin B-1, have surprisingly proven to be extremely effective.

The preparations according to the invention lead to a clearly effective, long-lasting and subjectively noticeable reduction in the itching on the skin.

Polidocanol is a short name for polyethylene glycol (9) monododecyl ether, an adduct of 9 moles of ethylene oxide with the dodecyl alcohol; it corresponds to the formula

C ₁₂ H ₂₅ - (0-CH ₂ -CH ₂ ) -OH

where n assumes an average value of 9 and the average molecular weight is about 600 g / mol. Polidocanol is also known as nonaoxythylene Monododecyl ether, PEG-9, lauryl ether, polyethylene glycol 450, lauryl ether polyoxyethylene (9). The trade names and distribution companies include Alfonic 1412-9.0 Ethoxylate (Condea Vista), Atlas G-4829 (Uniqema Americas), Calgene Nonionic L-9 (Calgene), Carsonon L-9 (Lonza Inc./Lonza Ltd.), Carsonon L. -985 (Lonza Inc./Lonza Ltd.), Hetoxol L-9 (Heterene), Hetoxol LS-9 (Heterene), Jeecol LA-9 (Jeen), Marlipal 24/90 (Condea Chemie (Mari)), Nikkol BL -9EX (Nikko), Procol LA-9 (Protameen), Sympatens-AL / 090 (Kolb), Unicol LA-9 (Universal Preserv-A-Chem).

In the presence of electrolytes, the emulsifiability of the polidocanol is not affected. Polidocanol is an amphiphilic compound with high capillary activity. Aqueous solutions show a high surface activity and accordingly a good spreading ability on the skin. Applied in aqueous solutions, polidocanol shows strong local anesthetic properties (K. Söhring and co-workers, Arch. Int. Pharmacodyn. 87, 301 [1951]; KJ Siems and K. Soehring, Arzneimittel.Forschung./Drug Res. 2 , 109 [1952]; K. Soehring and co-workers, Arch. Int. Pharmacodyn. 91, 112 [1952]; HS Zipf and co-workers, Arzneimittel.Forsch./Drug. Res. 7, 162 [1957] ).

Polidocanol is used in a proportion of 0.01 to 20% by weight, in particular 1 to 10% by weight, in the preparation.

Concentrates obtained from plants are known as essential oils, which are used as natural raw materials mainly in the perfume and food industry and which consist more or less of volatile compounds, such as real essential oils, citrus oils, absolute, resinoids. The term is often used to refer to the volatile constituents still contained in the plants. In the real sense, however, essential oils are mixtures of volatile components that are produced from vegetable raw materials by steam distillation.

Real essential oils consist exclusively of volatile components, the boiling point of which is predominantly between 150 and 300 ° C. Unlike, for example, fatty oils, they do not leave a permanent, transparent grease stain when dabbed on filter paper. Essential oils mainly contain hydrocarbons or monofunctional compounds such as aldehydes, alcohols, esters, ethers and ketones. Parent compounds are mono- and sesquiterpenes, phenylpropane derivatives and longer-chain aliphatic compounds.

Some essential oils are dominated by one ingredient (e.g. eugenol in clove oil with more than 85%), others are extremely complex. The organoleptic properties are often shaped not by the main components, but by minor or trace components, such as the 1,3,5-undecatrienes and pyrazines in Galbanum oil. Many of the commercially important essential oils have hundreds of identified components. A large number of ingredients are chiral, with an enantiomer predominating or being present very often, such as (-) - menthol in peppermint oil or (-) - linalyl acetate in lavender oil.

Menthol has proven to be a particularly preferred essential oil. Menthol is part of the well-known Japanese peppermint oil (CAS: 20747-49-3). The most important isomer is (-) - menthol. Menthol creates a pleasant feeling of cold when rubbed onto the skin due to surface anesthesia and irritation of the cold-sensitive nerves in the case of migraines or the like. It has been proven that the affected skin areas show normal or elevated temperature.

Other preferred essential oils which can be used are Oleum Eucalypti, Oleum Menthae piperitae, Oleum camphoratum, Oleum Rosmarini, Oleum Thymi, Oleum Pini sibricum and Oleum Pini silverstris, as well as the terpenes 1, 8-cineol and levomethanol and Oleum Abietis albae, Oleant Anisiis, Oleum Auris , Oleum Bergamottae, Oleum Calendulae infusum, Oleum Caryophylli, Oleum Chamomillae, Oleum Cinnamomi ceylanici, Oleum Citri, Oleum Citronellae, Oleum Cupressi, Oleum Cymbopogonis, Oleum Jecoris, Oleum Lavendulae, Oleum Macidis, Oleum Melalee, Oleum Melalee, Oleum Melanae, Oleum Melanae, Oleum Melanae, Oleum Melanae Menthae arvensis, Oleum Millefolium, Oleum Myrrhae, Oleum Myrte, Oleum Pini sibricum, Oleum Pinisilvestris, Oleum Salviae, Oleum Santali, Oleum Terebinthinae rectificat, Oleum Valerianae and Oleum Zingiberis.

The essential oils are used individually or in combination with others in a total amount of 0.001 to 10% by weight, in particular 0.01 to 1% by weight in the preparation. Common manifestations of cosmetic or dermatological preparations are finely dispersed multiphase systems in which one or more fat or oil phases are present in addition to one or more water phases. Of these systems, the actual emulsions are the most widespread.

In simple emulsions, finely dispersed droplets of the second phase (water droplets in W / O or lipid vesicles in O / W emulsions) are present in one phase, enclosed by an emulsifier shell. The droplet diameters of the usual emulsions are in the range from approx. 1 μm to approx. 50 μm. Such "macroemulsions" are, without further coloring additives, milky and opaque. Finer "macroemulsions" with droplet diameters in the range of about 10 ^{~ 1} micron to about 1 are .mu.m, are, again without coloring additives, bluish white and opaque.

Micellar and molecular solutions with particle diameters smaller than approx. 10 ^"2 μm are reserved to appear clear and transparent.

In contrast, the droplet diameter of transparent or translucent microemulsions is in the range from about 10 ^"2 μm to about 10 ^{" 1} μm. Such microemulsions are usually of low viscosity. The viscosity of many O / W type microemulsions is comparable to that of water.

The advantage of microemulsions is that active substances can be more finely dispersed in the disperse phase than in the disperse phase of "macroemulsions". Another advantage is that they can be sprayed due to their low viscosity. A disadvantage of the microemulsions of the prior art is that a high content of one or more emulsifiers must always be used, since the small droplet size requires a high interface between the phases, which generally has to be stabilized by emulsifiers.

The O / W emulsifiers preferred according to the invention include eumulgin B-1 from Cognis, an emulsion base corresponding to the designations polyethylene glycol (12) cetearyl ether, PEG-12 cetyl / stearyl ether, polyethylene glycol 600 cetyl / stearyl ether, polyoxyethylene (12) cetyl / Stearyl ether. This connection is also known under the name CETEARETH-12 and is sold under the following names by the following companies: Atlas G-4822 (Uniqema Americas), Jeecol CS-12 (Jeen), Procol CS-12 (Protameen), Sabowax CS 11 (Sabo), Sympatens-ACS / 120 (Kolb), Unimul-B-1 (Universal Preserv-A-Chem), Volpo CS12 (Croda Oleochemicals).

Myrj 52S from Uniqema, an emulsifier corresponding to the names Macrogol Stearate 2000, Polyethylene Glycol 2000, Monostearate Polyoxyethylene (40), Monostearate Polyoxyl 40, Stearate Stearethate 40, is also advantageous. This compound is also known under the name PEG-40 STEARATE and is distributed under the following names by the following companies: AEC PEG-40 Stearate (A & E Connock) Calgene POE (40) MS (Calgene) Crodet S40 (Croda Oleochemicals) Emerest 2715 (Henkel) Emerest 2715 (Henkel / COSPHA) Hetoxamate SA -40 (Heterene) Jeemate 2000-DPS (Jeen) Lanoxide-52 (Lanaetex) LIPOPEG-39-S (Lipo) Myrj 52 (Uniqema Americas) Myrj 52S (Uniqema Americas) Nikkol MYS-40 (Nikko) Pegosperse 1750 MS (Lonza Inc./Lonza Ltd.) Protamate 1540 DPS (Protameen) Protamate 2000 DPS (Protameen) Ritox 52 (RITA) ROL 52 (Fabriquimica) Sabowax SE 40 (Sabo) Simulsol M 52 (SEPPIC) Sipoic MS-40 (Specialty Industrial) Sympatens -BS / 400 (Kolb) Tego Acid S 40 P (Goldschmidt) Unipeg-S-40 (Universal Prese rv-A-Chem).

Cutina GMS (from Cognis) has proven to be very advantageous as a co-emulsifier, a co-emulsifier corresponding to the name 2,3-dihydroxypropyl octadecanoate, glycerol 1-stearate, glyceryl monostearate, gycerol 1 stearate, Jeechem HMS monostearin, octadecanoic acid, 2, 3-Dihydroxypropyl Ester Octadecanoic Acid, Monoester with 1, 2,3-Propanetriol Stearic Acid 1-Monoglyceride. This compound is also known as GLYCERYL STEARATE and is also known as AEC Glyceryl Stearate (A & E Connock) Aldo HMS (Lonza Inc./Lonza Ltd.) Aldo MS (Lonza Inc./Lonza Ltd.) Aldo MSLG ( Lonza Inc./Lonza Ltd.) Alkamuls GMS (Rhodia Inc.) Arlacel 129 (Uniqema Americas) Arlacel 161 (Uniqema Americas) Arlacel 169 (Uniqema Americas) Calgene GMS (Calgene) Capmul GMS (Abitec) Ceral Mex (Fabriquimica) Ceral MN (Fabriquimica) Ceral MNT (Fabriquimica) Cerasynt GMS (ISP Van Dyk) Cerasynt SD (ISP Van Dyk) Cithrol GMS N / E (Croda Oleochemicals) CPH-53-N (Hall) CPH-144-N (Hall) Cremophor GS 11 (BASF) Cutina GMS (Cognis) Emerest 2400 (Henkel) Emerest 2400 (Henkel /) ESTOL 1474 (Uniqema (Netherlands)) ESTOL 3740 (Uniqema (Netherlands)) Geleol (Gattefosse sa) Imwitor 191 (Condea Chemie (Witten)) Imwitor 900 (Condea Chemie (Witten)) Jeechem GMS-450 (Jeen) Jeechem HMS (Jeen) Kemester 5500 (Witco) Kemester 6000 (Witco) Kessco GMS (Akzo Nobel Surface Chemistry) KESSCO GMS (Stepan) KESSCO GMS 63F (Stepan) KESSCO GMS PURE (Stepan) Lanesta 24 (Lanaetex).

Further O / W emulsifiers or coemulsifiers are polypropoxylated O / W emulsifiers, the polyethooxylated or polypropoxylated O / V co-emulsifiers and / or emulsifiers being selected or being selected from the group of fatty alcohol ethoxylates of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -H, where R is a branched or unbranched alkyl, aryl or alkenyl radical and n is a number from 10 to 50 of the ethoxylated wool wax alcohols, the polyethylene glycol ethers of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -R ', where R and R' independently of one another are branched or unbranched alkyl or alkenyl radicals and n is a number from 10 to 80 - the fatty acid ethoxylates of the general formula

R-COO - (- CH ₂ -CH ₂ -O-) _n -H, where R is a branched or unbranched alkyl or alkenyl radical and n is a number from 10 to 40, of the etherified fatty acid ethoxylates of the general formula R-COO- ( -CH ₂ -CH ₂ -O-) _n -R ', where R and R' independently of one another are branched or unbranched alkyl or alkenyl radicals and n is a number from 10 to 80, of the esterified fatty acid ethoxylates of the general formula R-COO- ( -CH ₂ -CH ₂ -O-) _n -C (O) -R \ where R and R 'independently of one another are branched or unbranched alkyl or alkenyl radicals and n is a number from 10 to 80, the saturated and / or unsaturated polyethylene glycol glycerol fatty acid esters , branched and / or unbranched fatty acids and a degree of ethoxylation between 3 and 50, the ethoxylated sorbitan esters with a degree of ethoxylation from 3 to 100 - the cholesterol ethoxylates with a degree of ethoxylation between 3 and 50, the ethoxylated triglycerides with a degree of ethoxylation between 3 and 150, the alkyl ether carboxylic acids of the general formula

RO - (- CH ₂ -CH ₂ -O-) _n -CH ₂ -COOH or their cosmetically or pharmaceutically acceptable salts, where R is a branched or unbranched alkyl or alkenyl radical with 5-30 carbon atoms and n is one Represent a number from 5 to 30, the polyoxyethylene sorbitol fatty acid ester, based on branched or unbranched alkanoic or alkenoic acids and having a degree of ethoxylation of 5 to 100, for example of the sorbeth type, the alkyl ether sulfates or the acids of these sulfates on the general formula RO - (- CH ₂ -CH ₂ -O -) n-SO ₃ -H with cosmetically or pharmaceutically acceptable cations, where R is a branched or unbranched alkyl or alkenyl radical having 5 to 30 carbon atoms and n is a number from 1 to 50, the fatty alcohol propoxylates of the general formula RO- ( -CH ₂ -CH (CH ₃ ) -O-) _n -H, where R is a branched or unbranched alkyl or alkenyl radical and n is a number from 10 to 80, the polypropylene glycol ether of the general formula

RO - (- CH ₂ -CH (CH ₃ ) -O-) _n -R ', where R and R' independently of one another are branched or unbranched alkyl or alkenyl radicals and n is a number from 10 to 80 - the propoxylated wool wax alcohols, the etherified fatty acid propoxylates of the general formula R-COO - (- CH ₂ -CH (CH ₃ ) -O-) _n -R ', where R and R' independently of one another are branched or unbranched alkyl or alkenyl radicals and n is a number from 10 to 80 represent - the esterified fatty acid propoxylates of the general formula

R-COO - (- CH ₂ -CH (CH ₃ ) -O-) _π -C (O) -R \ where R and R 'independently of one another are branched or unbranched alkyl or alkenyl radicals and n is a number from 10 to 80 , the fatty acid propoxylates of the general formula R-COO - (- CH ₂ -CH (CH ₃ ) -O-) _n -H, where R is a branched or unbranched

Alkyl or alkenyl radical and n represent a number from 10 to 80, the polypropylene glycol glycerol fatty acid ester saturated and / or unsaturated, branched and / or unbranched fatty acids and a degree of propoxylation between 3 and 80 - the propoxylated sorbitan esters with a degree of propoxylation of 3 to 100 of the cholesterol propoxylates with a Degree of propoxylation from 3 to 100 of the propoxylated triglycerides with degree of propoxylation from 3 to 100 of the alkyl ether carboxylic acids of the general formula RO - (- CH ₂ -CH (CH ₃ ) O-) _n -CH ₂ -COOH or their cosmetically or pharmaceutically acceptable salts, where R is a branched or unbranched alkyl or alkenyl radical and n is a number from 3 to 50, the alkyl ether sulfates or the acids on which these sulfates are based, of the general formula RO - (- CH ₂ -CH (CH ₃ ) -O-) n-SO ₃ -H with cosmetically or pharmaceutically acceptable cations, where R is a branched or unbranched alkyl or Alkenyl radical having 5 to 30 carbon atoms and n represent a number from 1 to 50, the fatty alcohol ethoxylates / propoxylates of the general formula ROX _n -Y _m -H, where R is a branched or unbranched alkyl or

Represent alkenyl radical, where X and Y are not identical and each represent either an oxyethylene group or an oxypropylene group and n and m independently of one another are numbers from 5 to 50, the polypropylene glycol ether of the general formula ROX _n -Y _m -R ', where R and R' independently represent branched or unbranched alkyl or alkenyl radicals, where X and Y are not identical and each represent either an oxyethylene group or an oxypropylene group and n and m independently of one another represent numbers from 5 to 100, the etherified fatty acid propoxylates of the general formula R-COO-X _n -Y _m -R ', where R and R' independently represent branched or unbranched alkyl or alkenyl radicals, where X and Y are not identical and each have either an oxyethylene group or an oxypropylene group and n and m are independently numbers from 5 to 100 represent the fatty acid ethoxylates / propoxylates of the general formula R-COO-X _n -Y _m -H, where R is a v branched or unbranched alkyl or alkenyl radical, where X and Y are not identical and each represent either an oxyethylene group or an oxypropylene group and n and m independently of one another are numbers from 5 to 50.

It is advantageous to choose the fatty alcohol ethoxylates from the group of the ethoxylated stearyl alcohols, cetyl alcohols, cetylstearyl alcohols (cetearyl alcohols). The following are particularly preferred:

Polyethylene glycol (13) stearyl ether (Steareth-13), polyethylene glycol (14) stearyl ether (Steareth-14), polyethylene glycol (15) stearyl ether (Steareth-15), polyethylene glycol (16) - stearyl ether (Steareth-16), polyethylene glycol (17) stearyl ether (Steareth-17), polyethylene glycol (18) stearyl ether (steareth-18), polyethylene glycol (19) stearyl ether (steareth-19), polyethylene glycol (20) stearyl ether (steareth-20), polyethylene glycol (12) isostearyl ether (isosteareth-12), polyethylene glycol (13) isostearyl ether ( isosteareth-13), polyethylene glycol (14) isostearyl ether (isosteareth-14), polyethylene glycol (15) isostearyl ether (isosteareth-15), polyethylene glycol (16) isostearyl ether (isosteareth-16), polyethylene glycol (17) isostearyl ether (isosteareth- 17), polyethylene glycol (18) isostearyl ether

(isosteareth-18), polyethylene glycol (19) isostearyl ether (isosteareth-19), polyethylene glycol (20) isostearyl ether (isosteareth-20), polyethylene glycol (13) cetyl ether (ceteth-13), polyethylene glycol (14) cetyl ether (ceteth-14), Polyethylene glycol (15) cetyl ether (ceteth-15-), polyethylene glycol (16) cetyl ether (ceteth-16), polyethylene glycol (17) cetyl ether (ceteth-17), polyethylene glycol (18) cetyl ether (ceteth-18), polyethylene glycol (19) cetyl ether (Ceteth-19), polyethylene glycol (20) cetyl ether (Ceteth-20), polyethylene glycol (13) isocetyl ether (isoceteth-13), polyethylene glycol (14) isocetyl ether (isoceteth-14), polyethylene glycol (15) isocetyl ether (isoceteth-15) , Polyethylene glycol (16) isocetyl ether (isoceteth-16), polyethylene glycol (17) isocetyl ether (isoceteth-17), polyethylene glycol (18) isocetyl ether (isoceteth-18), polyethylene glycol (19) isocetyl ether (isoceteth-19), polyethylene glycol 20) isocetyl ether (isoceteth-20), polyethylene glycol (12) oleyl ether (oleth-12), polyethylene glycol (13) oleyl ether (oleth-13), polye ethylene glycol (14) oleyl ether (Oleth-14), polyethylene glycol (15) oleyl ether (Oleth-15), polyethylene glycol (12) lauryl ether (Laureth-12-), polyethylene glycol (12) isolauryl ether (isolaureth-12), polyethylene glycol (13) cetylstearyl - ether (Ceteareth-13), polyethylene glycol (14) cetylstearyl ether (Ceteareth-14), polyethylene glycol (15) cetylstearyl ether (Ceteareth-15), polyethylene glycol (16) cetylstearyl ether (Ceteareth-16), polyethylene glycol (17) cetylstearyl -17), polyethylene glycol (18) cetyl stearyl ether (ceteareth-18), polyethylene glycol (19) cetyl stearyl ether (cerateeth-19), polyethylene glycol (20) cetyl stearyl ether (ceteareth-20).

It is also advantageous to choose the fatty acid ethoxylates from the following group: polyethylene glycol (20) stearate, polyethylene glycol (21) stearate, polyethylene glycol (22) stearate, polyethylene glycol (23) stearate, polyethylene glycol (24) stearate, polyethylene glycol (25) stearate, Polyethylene glycol (12) isostearate, polyethylene glycol (13) isostearate, polyethylene glycol (14) isostearate, polyethylene glycol (15) isostearate, polyethylene glycol (16) isostearate, polyethylene glycol (17) isostearate, polyethylene glycol (18) isostearate, polyethylene glycol (19) iso stearate, polyethylene glycol (20) isostearate, polyethylene glycol (21) isostearate, polyethylene glycol (22) isostearate, polyethylene glycol (23) isostearate, polyethylene glycol (24) isostearate, polyethylene glycol (25) isostearate, polyethylene glycol (12) oleate, polyethylene glycol (13 ) oleate, Polyethylene glycol (14) oleate, polyethylene glycol (15) oleate, polyethylene glycol (16) oleate, polyethylene glycol (17) oleate, polyethylene glycol (18) oleate, polyethylene glycol (19) oleate, polyethylene glycol (20) oleate.

The sodium laureth-11-carboxylate can advantageously be used as the ethoxylated alkyl ether carboxylic acid or its salt.

Sodium laureth 1-4 sulfate can advantageously be used as alkyl ether sulfate. Polyethylene glycol (30) cholesteryl ether can advantageously be used as the ethoxylated cholesterol derivative. Polyethylene glycol (25) soyasterol has also proven itself. Polyethylene glycol (60) evening primrose glycerides can advantageously be used as ethoxylated triglycerides (evening primrose = evening primrose).

It is also advantageous to use the polyethylene glycol glycerol fatty acid esters from the group polyethylene glycol (20) glyceryl laurate, polyethylene glycol (21) glyceryl laurate, polyethylene glycol (22) glyceryl laurate, polyethylene glycol (23) glyceryl laurate, polyethylene glycol (6) glyceryl caprate / caprinate 20, glyceryl oleate, polyethylene glycol (20) glyceryl isostearate, polyethylene glycol (18) glyceryl oleate / cocoat to choose.

It is also favorable to choose the sorbitan esters from the group consisting of polyethylene glycol (20) sorbitan monolaurate, polyethylene glycol (20) sorbitan monostearate, polyethylene glycol (20) sorbitan monoisostearate, polyethylene glycol (20) sorbitan monopalmitate, polyethylene glycol (20) sorbitan monooleate.

In the preparations according to the invention, an unexpected synergistic development of active substances is shown by the combination of the active substances polidocanol and essential oils, in particular menthol, with the selected O / W emulsifiers. The selected O / W emulsifiers build a gel network in the coherent aqueous phase in the form that promotes the release of the active ingredients polidocanol and essential oil in such a way that the itch-relieving effect can develop immediately and yet sustainably.

The clinical test of the effectiveness of the preparation according to the invention is extremely positive and confirms the advantageous properties of the

Preparations. In a clinically controlled study, preparations according to the invention with 1% by weight menthol and 2% by weight polidocanol, 0.5 % By weight menthol and 2% by weight polidocanol and a placebo on several people between the ages of 18 and 60 years tested. The result:

• Immediate reduction in itching after application of the preparation • Intensification of the reduction in itching within 30 minutes after application until the stimulus is almost completely eliminated

• After a week of treatment, there is also a visible reduction in itching

• No difference between the preparations according to the invention used

In addition to water, other additives of the preparations according to the invention are substances customary in cosmetics, as described in more detail below.

Oils with different polarity, molecular weight and structure can be used as the oil phase of the preparation according to the invention. The oil component or all of the oil components of the preparation according to the invention is preferably selected from the group of the esters from saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids or hydroxyalkane carboxylic acids with a chain length of 1 to 44 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 1 to 44 carbon atoms, from the group of esters from aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 1 to 30 carbon atoms, provided that the oil component or the All of the oil components represent a liquid at room temperature. Such ester oils can then advantageously be selected from the group of isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononylisononanoate, 2-ethylhexyl ethylate, 2-ethylhexyl ethylhexyl palate, Octyldodecyl palmitate, oleyl oleate, olerlerucate, erucyl oleate, erucylerucate as well as synthetic, semi-synthetic and natural mixtures of such esters, e.g. Jojoba oil.

The oil phase can advantageously be selected from the group of branched and unbranched hydrocarbons, silicone oils, lanolins, adipic acid esters, butylene glycol diesters, dialkyl ethers or carbonates, the group of saturated or unsaturated, branched alcohols, and also fatty acid triglycerides, especially tri- glycerol esters of saturated and / or unsaturated, branched and / or unbranched AI can carboxylic acids with a chain length of 8 to 24, in particular 12 - 18 carbon atoms. The fatty acid triglycerides can, for example, advantageously be selected from the group of synthetic, semisynthetic and natural oils, for example olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil and the like.

The oil phase can advantageously also contain cyclic or linear silicone oils or consist entirely of such oils, although it is preferred to use an additional content of other oil phase components in addition to the silicone oil or the silicone oils.

Cyclomethicone (octamethylcyclotetrasiloxane) is advantageously used as the silicone oil to be used according to the invention. However, other silicone oils can also be used advantageously for the purposes of the present invention, for example hexamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane).

Dicapylyl carbonate, dicaprylyl ether, paraffin oil, coco caprylate / caprate, caprylic / capric triglyceride, cyclomethicone, dimethicone, octyldodecanol and natural oils such as e.g. Soybean oil, macadamia oil, evening primrose oil. Oil mixtures such as paraffin oil / dicaprylyether, paraffin oil / cococaprylate caprate can also be used very advantageously.

Advantageous oil components are also e.g. B. butyl octyl salicylate (for example that available under the trade name Hallbrite BHB from CP Hall), hexadecyl benzoate and butyl octyl benzoate and mixtures thereof (Hallstar AB) and / or diethyl hexyl naphthalate (Hallbrite TQ).

The oil components can advantageously be present in a content of 1 to 50% by weight, based on the total preparation, about 1 to 40% by weight are preferred.

The preparation can be further improved by using waxes (ester waxes, triglyceride waxes, ethoxylated waxes, etc.) in the oil phase or as an oil phase. It is preferred if the wax component or the entirety of the wax components is selected from the group of the esters from saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids or hydroxycarboxylic acids with a chain length of 1 to 80 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 1 to 80 C atoms, from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 1 to 80 C- Atoms, provided that the wax component or the entirety of the wax components represent a solid at room temperature, the natural waxes, the diesters of polyols and C10-C80 fatty acids, the ethoxylated waxes, the triglyceride waxes, the C16-C60 fatty acids and / or C16-C80 fatty alcohols, the mineral waxes.

The wax components from the group of the C _16-36 alkyl stearates, the C _10-4 o-alkyl stearates and the C ₂₀ can be used particularly advantageously. oAlkylisost.earate _I the C ₂ o _-40 dialkyldimerate, the Cι _8-38 alkylhydroxystearoyl stearate, the C20-40 dialkyldimerate, the C ₂ 0. 0- alkyl erucate, and also C ₃ o- ₅ o-alkyl beeswax, Cetyl palmitate, methyl palmitate, cetearyl behenate, octacosanyl stearate. Silicone waxes such as stearyltrimethylsilane / stearyl alcohol may also be advantageous.

Also advantageous in the sense of the present invention are ester waxes, the esters of

1. saturated and / or unsaturated, branched and / or unbranched mono- and / or dicarboxylic acid having 10 to 50 carbon atoms, preferably 15-45 carbon atoms and

2. Represent glycerin. Mono-, di- and triglycerides can be advantageous here.

The glycerides listed below are particularly advantageous:

Glyceride trade name available from

C-16-18 triglyceride Cremeol HF-52-SPC Aarhus Oliefabrik

Glyceryl hydroxystearate Naturchem GMHS Rahn

Hydrogenated Coco-Glyceride Softisan 100 Hüls AG

Caprylic acid / Capric acid / Isostearic acid / Softisan 649 Dynamit Nobel

Adipic acid triglyceride

C-, 8-36 Triglyceride Syncrowax HGLC Croda GmbH

Glyceryl tribehenate Syncrowax HRC Croda GmbH

Glyceryl tri (12-hydroxystearate) thixcin R Rheox / NRC

Cutina HR Cognis AG hydrogenated castor oil

C _16- 2 ₄ -triglyceride Cremeol HF-62-SPC Aarhus Oliefabrik It is particularly preferred to choose the wax components from the group of triglyceride waxes such as C18-38 triglyceride or tribehenin. It has also been found that ethoxylated waxes such as PEG-8 beeswax, PEG 6 sorbitan beeswax, PEG-2 hydrogenated castoroil, PEG-12 camamauba wax are advantageous.

In addition, the preparations according to the invention can contain dyes and / or pigments. The dyes and pigments can be selected from the corresponding positive list in the Cosmetics Ordinance or the EC list of cosmetic colorants. In most cases, they are identical to the colorants approved for food. Pigments can be of organic and inorganic origin, such as azo-type organic, indigoide, triphenylmethane-like, anthraquinone, and xanthine dyes known as D&C and FD&C blues, browns, greens, oranges, reds, yellows. Inorganic pigments consist of insoluble salts of certified dyes called lakes or iron oxides. For example, barium lakes, calcium lakes, aluminum lakes, titanium dioxide, mica and iron oxides can be used. Examples of AI salts are Red 3 Aluminum Lake, Red 21 Aluminum Lake, Red 27 Aluminum Lake, Red 28 Aluminum Lake, Red 33 Aluminum Lake, Yellow 5 Aluminum Lake, Yellow 6 Aluminum Lake, Yellow 10 Aluminum.Lake, Orange 5 Aluminum Lake, Blue 1 Aluminum Lake and combinations can be used.

As iron oxides or oxide hydrates, e.g. cosmetic yellow oxide C22-8073 (Sunchemical) cosmetic oxide MC 33-120 (Sunchemical), cosmetic brown oxide C33- 115 (Nordmann & Rassmann), cosmetic russet oxide C33-8075 (Sunchemical) known and possibly advantageous. Ultramarine blue (Les colorants Wacker) can be used as aluminosilicate.

Pearlescent pigments can also be incorporated into the emulsions according to the invention. These are, for example, from the companies Costenoble (Cloisonne type, Flamenco type, Low Luster type), Merck (Colorona types, Microna type, Timiron type, Colorona, Ronasphere), Les Colornats Wacker (Covapure, Vert oxyde de Chrome), Cadre (Colorona, Sicopearl), BASF (Sicopearl, Sicovit), Rona (Colorona). For example, Timiron Silk Gold and Colorona Red Gold have proven to be particularly advantageous pearlescent pigments. Advantageous color pigments are also titanium dioxide, mica, iron oxides (for example Fe ₂ O ₃ , Fe ₃ O, FeO (OH)) and / or tin oxide. Advantageous dyes are, for example, carmine, Berlin blue, chrome oxide green, ultramarine blue and / or manganese violet. It is particularly advantageous to choose the dyes and / or color pigments from the list below. (The fabrics are sorted by their Color Index Number.)

Color Index German name CAS-No. or Sumforfor

Number mel

10316 C-ext. Yellow 1 846-70-8

12075 C-O ranks 3468-63-1

14700 C-Red 57 4548-53-2

15510 C-ext.Orange 8 633-96-5

15585 C-Red 55 2092-56-0

15585: 1 C-Red 55 5160-02-1

15800: 1 C-ext. Red 57 6371-76-2

15850 Lithol Rubin 8 5858-81-1

15850: 1 C-Red 12 5281-04-9

15880: 1 C-ext. Red 61 6417-83-0

15980 C-Orange 9 C ₁₆ H ₁₀ N ₂ O ₇ S2 ^• 2Na

15985 C-Orange 10 2783-94-0

16035 C-Red 60 29956-17-6

17200 C-Red 58 C ₁₆ H ₁₃ N ₃ O ₇ S2 ^■ 2Na

19140 C-yellow 10 1934-21-0

20170 C-ext. Brown 4 1320-07-6 6371-84-2

26100 C-ext. Red 56 85-86-9

42053 C-Green 12 C37Η36N ₂ O ₁₀ S ₃ ^• 2Na

42090 C-Blue 21 2650-18-2

(Ammonium salt) 6371-85-3 37307-56-5

45170 C-Red 59 81-88-9

45170: 1 (Rhodamine B stearate) C28H31N2O3 ^• C ₁₈ H ₃₅ O ₂

45370: 1 C-Red 27 C oH-ιoBr ₂ θ ₅

45380 C-Red 30 17372-87-1 Color Index German name CAS-No. or Sumforfor

Number mel

45380: 2 tetrabromofluorescein 15086-94-9

45410 C-Red 34 18472-87-2

45410: 1 tetrabromotetrachlorofluorescein 13473-26-2

45425 C-Red 35 C ₂ oH ₁₀ l ₂ O ₅ - 2Na

45425: 1 mixture of fluorescein 518-40-7 38577-97-8

47000 C-ext. Yellow 23 8003-22-3

47005 C-yellow 11 8004-92-0

59040 C-ext. Yellow 24 6358-69-6

60725 C-ext. Violet 18 81-48-1

61565 C-Green 10 128-80-3

61570 C-Green 11 4403-90-1

73360 C-Red 28 2379-74-0

75120 C-Orange 12 8015-67-6

75130 C-Orange 11 7235-40-7

75170 guanine 68-94-0 73-40-50

75470 C-Red 50 C22H20O13

75480 Henna C ₁₀ H ₆ O ₃ (Lawson)

75810 C-Green 8 11006-34-1

75810 C-Green 7 479-61-8 519-62-0

77000 C pigment 1 AI

77007 C-Blue 16 57455-37-5

77019 C-White 11 12001-26-2

77288 C-Green 9 1308-38-9

77289 C-Green 14 12001-99-9

77400 bronze 7440-50-8

77491 C-Red 45 1309-37-1

77492 C-Brown 3 Fe ₂ O ₃ FeO (OH) (C-Yellow 8)

77499 C-Black 5 Fe ₃ O ₄

77510/20 C-Blue 17 C ₆ FeN ₆ ^• 4/3 Fe Color Index German name CAS-No. or Sumforfor

Number mel

77742 C-Violet 11 10101-66-3

77820 C pigment 2 7440-22-4

77891 C-White 7 13463-67-7 (TiO ₂ )

77947 C-White 8 1314-13-2

The dyes and pigments can be present either individually or in a mixture and can be coated with one another, with different coating effects generally causing different color effects.

The list of the dyes and color pigments mentioned, which can be used in the emulsions according to the invention, is of course not intended to be limiting.

Preparations according to the invention can also contain powder substances. Bismuth oxychloride, titanized mica, silicon dioxide (fumed silica), spherical silicon dioxide beads, polymethyl methacrylate beads, for example, are micronized as powder materials

Teflon, boron nitride, acrylate polymers, aluminum silicate, aluminum starch octenyl succinate,

Bentonite, calcium silicate, cellulose, chalk, corn starch, glyceryl starch, hectorite, hydrated silica, kaolin, magnesium hydroxides, magnesium oxide, magnesium silicates, magnesium trisilicate, maltodextrin, montmorillonite, microcrystalline cellulose, rice starch,

Silica, talc, mica, titanium dioxide, zinc laurate, zinc myristate, zinc neodecanoate,

Zinc rosinate, zinc stearate, polyethylene, aluminum oxide, attapulgite, calcium carbonate,

Calcium silicate, dextran, kaolin, nylon, silica silylate, silk powder, serecite, tin oxide,

Titanium hydroxide, trimagnesium phosphate, walnut shell powder or any mixtures can be used.

The above-mentioned customary cosmetic additives allow the preparation to be worn over a longer period of time without any externally visible losses, without the effectiveness of the preparation being reduced.

Furthermore, further advantageous active ingredients can be incorporated into the preparations. Thus, for example, Spitzwegericht tincture again proves to be more effective in reducing the itching compared to the preparations without Spitzwegericht tincture. In addition, care active ingredients can be incorporated, which are not limited to the fat-soluble active ingredients, but can also be selected from the group of water-soluble active ingredients, for example vitamins and the like. This results in a caring influence even with a longer wearing period.

An astonishing property of the preparations according to the invention is that they are very good vehicles for cosmetic or dermatological active ingredients in the skin, preferred active ingredients being antioxidants which can protect the skin against oxidative stress.

The preparations therefore advantageously contain one or more antioxidants. All of the antioxidants which are suitable or customary for cosmetic and / or dermatological applications can be used as inexpensive but nevertheless optional antioxidants. The antioxidants are particularly advantageously selected from the group consisting of amino acids (eg glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-camosine, L-camosine and its derivatives (e.g. anserine), carotenoids, carotenes (e.g. α-carotene, ß-carotene, lycopene) and their derivatives, lipoic acid and their derivatives (e.g. dihydroliponic acid), aurothioglucose, propylthiouracil and other thiols ( eg thioglycerin, thiosorbitol, thioglycolic acid, thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters) as well as their salts, diluryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and their derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) as well as sulfoximine compounds (e.g. buthioninsulfoximoxins, homocystine hionine sulfones, pentate, hexa-, heptahionine sulfoximine) in very low tolerable doses (e.g. pmol to μmol / kg), also (metal) chelators (e.g. α-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids (e.g. citric acid, Lactic acid, malic acid), humic acid, bile acid, bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (eg gamma-linolenic acid, linoleic acid, oleic acid), folic acid and its derivatives, ubiquinone and ubiquinol their derivatives , Vitamin C and derivatives (e.g. ascorbyl palmitate, Mg - ascorbyl phosphate, ascorbylacetate), isoascorbic acid and its derivatives, tocopherols and derivatives (e.g. vitamin E acetate), vitamin A and derivatives (vitamin A - palmitate) and coni ferylbenzoat benzoate of benzoin, rutinic acid and derivatives thereof, ferulic acid and derivatives thereof, butylhydroxytoluene, butylhydroxyanisole, Nordihydroguajakharzsäure, Nordihy- droguajaretsäure, trihydroxybutyrophenone, uric acid and derivatives thereof, mannose and derivatives thereof, zinc and derivatives thereof (for example ZnO, ZnSO ₄₎ selenium and its Derivatives (eg selenium methionine), stilbenes and their derivatives (eg stilbene oxide, trans-stilbene oxide) and the derivatives suitable according to the invention (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids) of these active substances.

If vitamin E and / or its derivatives represent the antioxidant (s), it is advantageous to choose their respective concentrations from the range of 0.001-10% by weight, based on the total weight of the formulation.

If vitamin A or vitamin A derivatives or carotenes or their derivatives represent the antioxidant or antioxidants, it is advantageous to add their respective concentrations in the range from 0.001 to 10% by weight, based on the total weight of the formulation choose.

According to the invention, active substances can also be selected very advantageously from the group of lipophilic active substances, in particular from the following group: acetylsalicylic acid, atropine, azulene, hydrocortisone and its derivatives, for example hydrocortisone 17-valerate, vitamins, for example ascorbic acid and its derivatives, vitamins of B and D series, very cheap the vitamin B ^ the vitamin B ₁₂ the vitamin D ^ but also bisabolol, unsaturated fatty acids, especially the essential fatty acids (often called vitamin F), especially γ-linolenic acid, oleic acid, eicosapentaenoic acid, Docosahexaenoic acid and its derivatives, chloramphenicol, caffeine, prostaglandins, thy- mol, camphor, extracts or other products of plant and animal origin, eg evening primrose oil, borage oil or currant oil, fish oils, cod liver oil but also ceramides and ceramide-like compounds and so on.

It is also advantageous to select the active ingredients from the group of refatting substances, for example Purcellin Oil®, Eucerit® and Neocerit®.

The active ingredient (s) are particularly advantageously selected from the group of

NO synthase inhibitors, especially when the preparations according to the invention for the treatment and prophylaxis of the symptoms of intrinsic and / or extrinsic Skin aging and to treat and prevent the harmful effects of ultraviolet radiation on the skin. The preferred NO synthase inhibitor is nitroarginine.

The active ingredient (s) are furthermore advantageously selected from the group comprising catechins and bile esters of catechins and aqueous or organic extracts from plants or parts of plants which contain catechins or bile esters of catechins, such as, for example, the leaves of the Theaceae plant family , especially the species Camellia sinensis (green tea). Their typical ingredients (such as polyphenols or catechins, caffeine, vitamins, sugar, minerals, amino acids, lipids) are particularly advantageous.

Catechins are a group of compounds which are to be understood as hydrogenated flavones or anthocyanidins and derivatives of "catechins" (catechol, 3,3 ', 4', 5,7-flavanpentaol, 2- (3,4- Dihydroxyphenyl) -chroman-3,5,7-triol) Also epicatechin ((2R, 3R) -3,3 ', 4 \ 5,7-flavanpentaol) is an advantageous active substance in the sense of the present invention.

Preferred active substances are also polyphenols or catechins from the group (-) - catechol, (+) - catechin, (-) - catechin gallate, (-) - gallocatechin gallate, (+) - epicatechin, (-) - epicatechin, ( -) - epicatechin gallate, (-) - epigallocatechin, (-) - epigallocatechin gallate.

Flavon and its derivatives (often also collectively called "flavones") are advantageous active substances in the sense of the present invention. They are characterized by the following basic structure (substitution positions specified):

Some of the more important flavones, which can also preferably be used in preparations according to the invention, are listed in the table below:

In nature, flavones usually occur in glycosidated form.

According to the invention, the flavonoids are preferably selected from the group of substances of the generic structural formula

where Z to Z _{7 are} independently selected from the group H, OH, alkoxy and hydroxyalkoxy, where the alkoxy or hydroxyalkoxy groups can be branched and unbranched and can have 1 to 18 carbon atoms, and wherein Gly is selected from the group Group of the mono- and oligoglycoside residues. According to the invention, the flavonoids can also be advantageously selected from the group of substances of the generic structural formula

where Z ₁ to Z ₆ are selected independently of one another from the group H, OH, alkoxy and hydroxyalkoxy, where the alkoxy or hydroxyalkoxy groups are branched and unbranched and can have 1 to 18 carbon atoms, and wherein Gly is selected is from the group of mono- and oligoglycoside residues.

Such structures can preferably be selected from the group of substances of the generic structural formula

where Gly _1? Gly ₂ and Gly ₃ independently or represent monoglycoside residues. Gly ₂ or Gly ₃ can also represent, individually or together, saturations by hydrogen atoms.

Gly-i, Gly ₂ and Gly ₃ are preferably selected independently of one another from the group of the hexosyl radicals, in particular the rhamnosyl radicals and glucosyl radicals. However, other hexosyl radicals, for example allosyl, altrosyl, galactosyl, gulosyl, idosyl, mannosyl and talosyl, may also be used advantageously. It can also be advantageous according to the invention to use pentosyl residues. Zi to Z ₅ are advantageously selected independently of one another from the group H, OH, methoxy, ethoxy and 2-hydroxyethoxy, and the flavone glycosides have the structure

The flavone glycosides according to the invention from the group which are represented by the following structure are particularly advantageous:

where Gly ^ Gly ₂ and Gly ₃ independently of one another represent monoglycoside residues or. Gly ₂ or Gly ₃ can also represent, individually or together, saturations by hydrogen atoms.

Gly ^ Gly and Gly ₃ are preferably selected independently of one another from the group of the hexosyl residues, in particular the rhamnosyl residues and glucosyl residues. However, other hexosyl radicals, for example allosyl, altrosyl, galactosyl, gulosyl, idosyl, mannosyl and talosyl, may also be used advantageously. It can also be advantageous according to the invention to use pentosyl residues.

For the purposes of the present invention, it is particularly advantageous to select the flavone glycoside (s) from the group α-glucosylrutin, α-glucosylmyricetin, α-glucosyliso- quercitrin, α-glucosylisoquercetin and α-glucosylquercitrin. According to the invention, α-glucosylrutin is particularly preferred.

Also advantageous according to the invention are naringin (aurantiin, naringenin-7-rhamnoglucoside), hesperidin (S'.δJ-trihydroxy ^ '- methoxyflavanon ^ -rutinoside, hesperidoside, hesperetin-7-O-rutinoside). Rutin (3,3 ', 4', 5,7-pentahydroxyflyvon-3-rutinoside, quercetin-3-rutinoside, sophorin, birutan, rutabion, taurutin, phytomelin, melin), troxerutin (3,5-di-hydroxy-3 ', 4', 7-tris (2-hydroxyethoxy) flavon-3- (6-O- (6-deoxy-α-L-mannopyranosyl) -ß-D-glucopyranoside)), monoxerutin (3,3 ', 4 ', 5-tetrahydroxy-7- (2-hydroxyethoxy) flavon-3- (6- O- (6-deoxy-α-L-mannopyranosyl) -ß-D-glucopyranoside)), dihydrorobinetin (3,3' , 4 ', 5', 7-pentahydroxyflavanone), taxifolin (3,3 ', 4', 5,7-pentahydroxyflavanone), eriodictyol-7-glucoside (3 ', 4', 5,7-tetrahydroxyflavanone-7 -glucoside), flavanomareϊn (3 ', 4', 7,8-tetra-hydroxyflavanone-7-glucoside) and isoquercetin (3,3 ', 4', 5,7-pentahydroxyflavanone-3- (ß-D-glucopyranoside) ,

It is also advantageous to choose the active ingredient (s) from the group of ubiquinones and plastoquinones.

Ubiquinones are characterized by the structural formula

and represent the most widespread and thus best studied biochinones. Depending on the number of isoprene units linked in the side chain, ubiquinones are classified as Q-1, Q-2, Q-3 etc. or according to the number of C- Atoms referred to as U-5, U-10, U-15, etc. They preferably occur with certain chain lengths, e.g. B. in some microorganisms and yeasts with n = 6. Q10 predominates in most mammals, including humans.

Coenzyme Q10, which is characterized by the following structural formula, is particularly advantageous:

Plastoquinones have the general structural formula

on. Plastoquinones differ in the number n of isoprene residues and are named accordingly, e.g. B. PQ-9 (n = 9). There are also other plastoquinones with different substituents on the quinone ring.

Creatine and / or creatine derivatives are also preferred active substances in the sense of the present invention. Creatine is characterized by the following structure:

Preferred derivatives are creatine phosphate and creatine sulfate, creatine acetate, creatine ascorbate and the derivatives esterified on the carboxyl group with mono- or polyfunctional alcohols.

Another advantageous active ingredient is L-carnitine [3-hydroxy-4- (trimethylammonio) -butter-acid-betaine]. Also acyl-carnitine, which is selected from the group of substances of the following general structural formula

where R is selected from the group of branched and unbranched alkyl radicals having up to 10 carbon atoms are advantageous active ingredients in the sense of the present invention. Propionylcamitine and in particular acetylcarnitine are preferred. Both entantiomers (D- and L-form) can be used advantageously for the purposes of the present invention. It can also be advantageous to use any mixture of enantiomers, for example a racemate of D and L form. Further advantageous active ingredients are sericoside, pyridoxol, aminoguadin, phytochelatin, isoflavones (genistein, daidzein, daidzin, glycitin), niacin, tyrosine sulfate, dioic acid, adenosine, pyridoxine, arginine, vitamin K, biotin and flavoring agents as well as active ingredient combinations, sericoside combinations ,

In addition, one of the most important tasks of cosmetic and / or dermatological preparations is the moistening and moisture regulation of the skin. For this purpose, so-called moisturizers are added to the preparations in addition to water as a component of all emulsions. Synthetic humectants are substitutes for the natural moisturizing factor (English Natural Moisturizing Factor NMF), which consists of 40% free amino acids, 12% pyroglutamic acid, 12% lactates, 7% urea, 1.5% uric acid as well as glucosamine, creatinine and various salts.

In addition to hydrolyzed proteins, polyols (polyhydric alcohols) are primarily used as synthetic humectants.

The most important representative of the polyols is glycerin (glycerol, 1,2,3-propanetriol), a colorless and odorless, sweet-tasting liquid. Glycerin has the following structure:

H ₂ C - OH

HC-OH

IH ₂ C-OH Another important representative of the polyols is sorbitol, a pentavalent alcohol that is found in rowan berries and can be obtained synthetically by reducing glucose. Sorbitol is characterized by the following structure:

CH ₂ OH

H - C - OH

I HO - C - H

I H - C - OH

CH ₂ OH In particular, moisturizers chitosan, fucogel, lactic acid, propylene glycol, sorbitol, polyethylene glycol, dipropylene glycol, butylene glycol, mannitol, sodium pyrolidonecarboxylic acid, glycine hyaluronic acid and its salts, amino acids such as glycine, urea, sodium and potassium salts can be more easily bound to the skin. By using waxes (ester waxes, triglyceride waxes, ethoxylated waxes, etc.) in the oil phase or as an oil phase, the adhesion of the active ingredients and moisturizers can be further improved.

The moisture content of the skin can be determined using comeometric measurements. The dielectric properties of the stratum corneum are examined using a corneometer. The corneometer consists of a stray capacitor, the capacitance of which is (also) determined by the dielectric properties of the stratum corneum. In order to determine how long the skin moisturization caused by a cosmetic and / or dermatological preparation lasts, the moisture content of the skin is determined in each case before application and two hours after application of the cosmetic and / or dermatological preparation under constant measuring conditions. It has been found in these investigations that the preparation according to the invention containing moisturizers has a positive influence on the moisture balance of the skin, which is extremely pleasant for the skin damaged by skin irritation.

The list of the additional active substances or combinations of active substances mentioned which can be used in the preparations according to the invention is of course not intended to be limiting. The active ingredients can be used individually or in any combination with one another. It may be possible and advantageous to use the preparations according to the invention as the basis for pharmaceutical formulations. Mutatis mutandis, corresponding requirements apply to the formulation of medical preparations. The transitions between pure cosmetics and pure pharmaceuticals are fluid. In principle, all classes of active substances are suitable as pharmaceutical active substances, lipophilic active substances being preferred. Examples are: antihistamines, antiphlogistics, antibiotics, antifungals, active substances that promote blood circulation, keratolytics, antihistamines, antiphlogistics, antibiotics, antifungals, substances that promote blood circulation, keratolytics, hormones, steroids, vitamins, hormones, etc., steroids, steroids, steroids,

It may be possible and advantageous to incorporate repellents into the preparations according to the invention. Particularly advantageous repellent active ingredients for the purposes of the present invention are the above-mentioned active ingredients N, N-diethyl-3-methylbenzamide, 3- (Nn-butyl-N-acetylamino) propionic acid ethyl ester, 1-piperidinecarboxylic acid 2- (2-hydroxyethyl) -1-methyl propyl ester and dimethyl phthalate.

It is also advantageous in the sense of the present invention to produce cosmetic and dermatological preparations, the purpose of which is also to protect against sunlight. UV-A or UV-B filter substances are usually incorporated. UV protection substances, like antioxidants and, if desired, preservatives, also provide effective protection of the preparations themselves against spoilage.

Accordingly, the preparations in the sense of the present invention preferably contain at least one UV-A, UV-B and / or broadband filter substance. The formulations may, although not necessary, optionally also contain one or more organic and / or inorganic pigments as UV filter substances, which may be present in the water and / or the oil phase.

Particularly advantageous UV filter substances which are liquid at room temperature for the purposes of the present invention are homomenthyl salicylate (INCI: homosalicylate), 2-ethylhexyl-2-cyano-3,3-diphenylacrylate (INCI: octocrylene), 2-ethylhexyl-2-hydroxybenzoate (2- Ethylhexyl salicylate, ethylhexyl salicylate, INCI: ethylhexyl salicylate) and esters of cinnamic acid, preferably 4-methoxycinnamic acid (2-ethylhexyl) ester (2-ethylhexyl 4-methoxycinnamate, INCI: ethylhexyl methoxycinnamate) and 4-methoxycinnamate-4-methoxycinnamate (4-methoxycinnamate) , INCI: Isoamyl p-methoxycinnamate), 3- (4- (2,2-bis-ethoxycarbonylvinyl) -phenoxy) propenyl) -methoxysiloxane / dimethylsiloxane copolymer which is available, for example, from Hoffmann La Röche under the trade name Parsol® SLX.

Preferred inorganic pigments are metal oxides and / or other metal compounds which are sparingly soluble or insoluble in water, in particular oxides of titanium (TiO ₂ ), zinc (ZnO), iron (e.g. Fe ₂ O ₃ ), zirconium (ZrO ₂ ), silicon ( SiO ₂ ), manganese (e.g. MnO), aluminum (Al ₂ O ₃ ), cerium (e.g. Ce ₂ O ₃ ), mixed oxides of the corresponding metals as well as mixtures of such oxides and the sulfate of barium (BaSO ₄ ).

For the purposes of the present invention, the pigments can also advantageously be used in the form of commercially available oily or aqueous predispersions. Dispersing aids and / or solubilizing agents can advantageously be added to these predispersions.

According to the invention, the pigments can advantageously be surface-treated (“coated”), for example, a hydrophilic, amphiphilic or hydrophobic character should be formed or retained. This surface treatment can consist in that the pigments are prepared with a thin hydrophilic and / or hydrophobic inorganic and / or organic layer The various surface coatings can also contain water for the purposes of the present invention.

Inorganic surface coatings in the sense of the present invention can consist of aluminum oxide (Al O ₃ ), aluminum hydroxide Al (OH) ₃ , or aluminum oxide hydrate (also: alumina, CAS no .: 1333-84-2), sodium hexametaphosphate (NaPO ₃ ) ₆ , Sodium metaphosphate (NaPO ₃ ) _n , silicon dioxide (SiO ₂ ) (also: silica, CAS No .: 7631-86- 9), or iron oxide (Fe ₂ O ₃ ). These inorganic surface coatings can occur alone, in combination and / or in combination with organic coating materials.

Organic surface coatings in the sense of the present invention can consist of vegetable or animal aluminum stearate, vegetable or animal stearic acid, lauric acid, dimethylpolysiloxane (also: dimethicone), Methylpolysiloxane (Methicone), Simethicone (a mixture of dimethylpolysiloxane with an average chain length of 200 to 350 dimethylsiloxane units and silica gel) or alginic acid. These organic surface coatings can occur alone, in combination and / or in combination with inorganic coating materials.

Zinc oxide particles and predispersions of zinc oxide particles suitable according to the invention are available under the following trade names from the companies listed:

Suitable titanium dioxide particles and predispersions of titanium dioxide particles are available under the following trade names from the companies listed:

Advantageous UV-A filter substances for the purposes of the present invention are dibenzoyl methane derivatives, in particular 4- (tert-butyl) -4'-methoxydibenzoyl methane (CAS No. 70356-09-1), which is available from Givaudan under the Parsol brand ^® 1789 and is sold by Merck under the trade name Eusolex® 9020. Advantageous further UV filter substances in the sense of the present invention are sulfonated, water-soluble UV filters, such as. B .:

• Phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid and its salts, especially the corresponding sodium, potassium or triethanolammonium salts, in particular phenylene-1 , 4-bis- (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid-bis-sodium salt with the INCI name bisimidazylate (CAS no .: 180898-37-7), which, for example, under the trade name Neo Heliopan AP is available from Haarmann &Reimer; Salts of 2-phenylbenzimidazole-5-sulfonic acid, such as its sodium, potassium or triethanolammonium salt, and the sulfonic acid itself with the INCI name

Phenylbenzimidazole sulfonic acid (CAS No. 27503-81-7), which is available, for example, under the trade name Eusolex 232 from Merck or under Neo Heliopan Hydro from Haarmann &Reimer; 1, 4-di (2-oxo-10-sulfo-3-bornylidenemethyl) -benzene (also: 3,3 '- (1,4-phenylenedimethylene) -bis- (7,7-dimethyl-2-oxo -bicyclo- [2.2.1] hept-1-ylmethane sulfonic acid) and its salts (especially the corresponding 10-sulfato compounds, especially the corresponding sodium, potassium or triethanolammonium salt), which is also called benzene-1,4 -di (2-oxo-3-bornylidenemethyl-10-sulfonic acid) Benzene-1, 4-di (2-oxo-3-bornylidenemethyl-10-sulfonic acid) has the INCI name Terephtalidene Dicampher Sulfonic Acid (CAS.- No .: 90457-82-2) and is available, for example, under the trade name Mexoryl SX from Chimex;

• Sulfonic acid derivatives of 3-benzylidene camphor, such as. B. 4- (2-oxo-3-bornylidene-methyl) benzenesulfonic acid, 2-methyl-5- (2-oxo-3-bornylidene-methyl) sulfonic acid and salts thereof.

Advantageous UV filter substances in the sense of the present invention are also so-called broadband filters, i.e. Filter substances that absorb both UV-A and UV-B radiation.

Advantageous broadband filters or UV-B filter substances are, for example, triazine derivatives, such as. B.

• 2,4-bis - {[4- (2-ethylhexyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine (INCI: bis-ethylhexyloxyphenol methoxyphenyl triazine ), which is available under the trade name Tinosorb® S from CIBA-Chemicals GmbH; Diethylhexylbutylamidotriazon (INCI: Diethylhexyl Butamido Triazone), which is available under the trade name UVASORB HEB from Sigma 3V; 4,4 ', 4 "- (1,3 _l 5-triazine-2,4,6-triyltriimino) -tris-benzoic acid tris (2-ethylhexyl ester), also: 2,4,6-tris [anilino- (p-carbo-2'-ethyl-1'-hexyloxy)] - 1, 3,5-triazine (INCI: Ethylhexyl Triazone), which is sold by BASF Aktiengesellschaft under the trade name UVINUL® T 150.

Further triazine derivatives which are advantageous in the context of the present invention are 2,4-bis - {[4- (3-sulfonato) -2-hydroxypropyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) - 1,3,5-triazine sodium salt, the 2,4-bis - {[4- (3- (2-propyloxy) -2-hydroxypropyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl ) -1, 3,5-triazine, the 2,4-bis - {[4- (2-ethylhexyloxy) -2-hydroxy] phenyl} -6- [4- (2-methoxyethyl-carboxyl) - phenylamino] -1, 3,5-triazine, the 2,4-bis- {[4- (3- (2-propyloxy) -2-hydroxypropyloxy) -2-hydroxy] phenyl} -6- [4 - (2-ethyl-carboxyl) - phenylamino] -1, 3,5-triazine, the 2,4-bis - {[4- (2-ethyl-hexyloxy) -2-hydroxy] phenyl} -6- ( 1-methyl-pyrrol-2-yl) -1,3,5-triazine, the 2,4-bis - {[4-tris (trimethylsiloxysilylpropyloxy) -2-hydroxy] phenyl} -6- (4- methoxyphenyl) -1, 3,5-triazine, the 2,4-bis - {[4- (2 "-methylpropenyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) -1, 3rd , 5-triazine and the 2,4-bis - {[4- (1 ', 1', 1 ', 3', 5 ', 5', 5'-heptamethylsiloxy-2 "-methyl-propyloxy) -2- hydroxy] phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine.

An advantageous benzotriazole for the purposes of the present invention is 2,2'-methylene-bis- (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) phenol) Broadband filter, which by the chemical structural formula

is marked and is available under the trade name Tinosorb® M from CIBA-Chemical GmbH. An advantageous benzotriazole for the purposes of the present invention is also 2- (2H-benzotriazol-2-yl) -4-methyl-6- [2-methyl-3- [1, 3,3,3-tetramethyl-1- [ (trimethylsilyl) oxy] disiloxanyl] propyl] phenol (CAS No .: 155633-54-8) with the INCI name Drometrizole Trisiloxane, which is characterized by the chemical structural formula

is marked.

Further advantageous benzotriazoles for the purposes of the present invention are [2,4'-dihydroxy-3- (2H-benzotriazol-2-yl) -5- (1, 1, 3,3-tetramethylbutyl) -2'-n-octoxy- 5'-benzoyl] di-phenylmethane, 2,2 'methylene-bis- [6- (2H-benzotriazol-2-yl) -4- (methyl) phenol], 2,2'-methylene-bis- [6- (2H-benzotiazol-2-yl) -4- (1, 1, 3,3-trtramethylbutyl) phenol], 2- (2'-

Hydroxy-5'-octylphenyl) benzotriazole, 2- (2'-Hydroxy-3 ', 5'-di-t-amylphenyl) benzotriazole and 2- (2'-Hydroxy-5'-methylphenyl) benzotriazole.

The other UV filter substances can be oil-soluble or water-soluble.

Advantageous oil-soluble UV-B and / or broadband filter substances in the sense of. present invention are e.g. B .:

^■ 3-benzylidene camphor derivatives, preferably 3- (4-methylbenzylidene) camphor, 3-benzylidene camphor;

^■ 4-aminobenzoic acid derivatives, preferably 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester, 4- (dimethylamino) benzoic acid amyl ester;

^■ 3- (4- (2,2-bis ethoxycarbonylvinyl) phenoxy) propenyl) - methoxysiloxan / dimethylsiloxane - copolymer which is obtainable for example from Hoffmann La Roche under the trade name Parsol SLX.

A further light protection filter substance according to the invention to be used advantageously is ethylhexyl-2-cyano-3,3-diphenylacrylate, obtainable (octocrylene) from BASF under the name Uvinul ^® N 539th The hydroxybenzophenone, in particular aminobenzophenone, was also found to be suitable light protection filters in combination with acrylamide polymers or copolymers and can therefore advantageously be present in the preparation according to the invention.

The list of the UV filters mentioned, which can be used in the sense of the present invention, should of course not be limiting.

The preparations according to the invention advantageously contain the substances which absorb UV radiation in the UV-A and / or UV-B range in a total amount of, for. B. 0.1% by weight to 30% by weight, preferably 0.5 ^" to 20% by weight, in particular 1.0 to 15.0% by weight, in each case based on the total weight of the preparations, in order to provide cosmetic preparations to protect the skin from the entire range of ultraviolet radiation.

The cosmetic and dermatological preparations according to the invention can contain cosmetic auxiliaries as are usually used in such preparations, e.g. B. preservatives, preservation aids, bactericides, perfumes, anti-foaming substances, thickeners and / or fillers that improve the feeling on the skin.

The application form of the preparation according to the invention can optionally be set as a gel, cream, lotion, spray, as a drug delivery system or over impregnated wipes.

In the technical sense, gels are understood to mean: Relatively dimensionally stable, easily deformable disperse systems composed of at least two components, which as a rule consist of a - usually solid - colloidally divided substance made up of long-chain molecular groups (e.g. gelatin, silica, polysaccharides) as a scaffold and a liquid di - Spersmittel (eg water) exist. The colloidally divided substance is often referred to as a thickening or gelling agent. It forms a spatial network in the dispersion medium, whereby individual colloidal particles can be more or less firmly linked to one another via electrostatic interaction. The dispersing agent that surrounds the network is characterized by electrostatic affinity for the gelling agent, ie a predominantly polar (in particular: hydrophilic) Gelling agent preferably gels a polar dispersing agent (in particular: water), whereas a predominantly non-polar gelling agent preferably gels non-polar dispersing agent.

Strong electrostatic interactions, which are realized, for example, in hydrogen bonds between the gelling agent and the dispersing agent, but also between the dispersing agent molecules, can also lead to strong crosslinking of the dispersing agent. Hydrogels can consist of almost 100% water (in addition to, for example, about 0.2-1.0% of a gelling agent) and have a firm consistency. The water content is in ice-like structural elements, so that gels therefore do justice to their origin [from Latin "gelatum" = "frozen" via the alchemical expression "gelatina" (16th century) for nhdt. "Gelatin"].

Lipogels and oleogels (from waxes, fats and fatty oils) and carbogels (from paraffin or petrolatum) are also common in cosmetic and pharmaceutical galenics. In practice, a distinction is made between oleogels, which are practically anhydrous, and hydrogels, which are practically fat-free. Most of the time, gels are transparent. In cosmetic or pharmaceutical galenics, gels are usually characterized by a semi-solid, often flowable consistency.

So-called surfactant gels are also common preparations of the prior art. This is understood to mean systems which, in addition to water, have a high concentration of emulsifiers, typically more than about 25% by weight, based on the overall composition. If solubilized in these surfactant gels, also called “surfactant gels” in technical terms, oil components, microemulsion gels are obtained, which are also referred to as “ringing gels”. By adding nonionic emulsifiers, for example alkyl polyglycosides, it is possible to obtain cosmetically more elegant microemulsion gels.

It is known per se to combine the droplets of a low-viscosity, in particular thin, microemulsion with crosslinking substances in order to obtain the three-dimensional network of a gel in this way. A cream is a non-free-flowing preparation that has a viscosity at 25 ° C of more than 10,000 mPa * s (Viscotester VT-02, Haake). Lotion is a free-flowing preparation that has a viscosity at 25 ° C of 2000-10,000 mPa * s (Viscotester VT-02, Haake).

Furthermore, the preparations according to the invention can be used very well as impregnation medium for wipes and tissues which can be used by the consumer wet or dry. The compositions with the ultra-fine droplets are easily drawn onto the fiber, which is an advantage.

It is also possible to provide the preparations according to the invention in the form of drug delivery systems. Drug delivery systems are plaster-like medicinal forms that contain the active substance in the form of a reservoir from which the active substance is released over a longer period according to the 0th order. Because of these properties, drug delivery systems are able to supply the organism with constant amounts of active ingredient per unit of time over a long period of time, regardless of the active ingredient concentration in the reservoir, and are therefore assigned to the group of prolonged-release medicinal products.

A distinction is made between drug delivery systems and topical and transdermal delivery. The topical formulations contain active substances, the release and action of which is limited to the area directly below and in the vicinity of the application site. The transdermal formulations, on the other hand, contain active ingredients that are applied through the skin in order to create an effective active ingredient level in the entire organism by penetrating into the vascular system. The drug delivery systems have a number of advantages over other pharmaceutical forms (e.g. ointment, sprays, suppositories, tablets):

• Due to the long duration of action of the drug delivery systems, patient compliance is significantly improved compared to pharmaceutical forms that have to be applied several times a day.

The application of the drug delivery systems can lower the dose, thereby reducing the side effects of active substances, e.g. have a narrow therapeutic index, is made possible.

• If side effects occur, the application of the active ingredient can be stopped suddenly by removing the drug delivery system. • The constant release of the active ingredient prevents the fluctuations in the active ingredient concentration that occur during repeated application during the day in the area of the skin and in the serum.

• The transdermal application reduces the first-pass metabolism of the drug compared to oral dosage forms, since the metabolism in the area of the skin in the

Compared to the metabolism in the stomach and liver is significantly lower. As a result, the dose of the drugs administered with drug delivery systems is lower in comparison to the oral dosage forms.

• In contrast to oral medicinal products, the drug delivery systems do not have to be expected to influence food through the penetration of the medicinal product.

• The dosage can be easily defined via the area of the drug delivery systems.

The preparations according to the invention are advantageously prepared in such a way that a mixture of the basic components, including water phase, oil phase, one or more of the O / W emulsifiers according to the invention, if desired one or more co-emulsifiers, and, if desired, further auxiliaries, additives and / or active ingredients, to a temperature which corresponds at least to the melting temperature of the high-melting oil component, and then cools the emulsion formed to room temperature, according to the invention the active ingredient (s) polidocanol and essential oils and possibly thickeners can be added at any time during the preparation. The entire process is preferably carried out with stirring.

The following examples are intended to illustrate the present invention without restricting it. Unless otherwise stated, all quantities, parts and percentages are based on the weight and the total amount or on the total weight of the preparations. Examples O / W emulsions

After application to the irritated skin, all of the exemplary preparations listed show an immediate reduction in itching or even loss of itching. Furthermore, the preparations according to the invention are easy to apply to the skin and can be distributed comfortably.

Claims

claims:

1. Containing cosmetic preparation

- Water,

- one or more OΛ / V emulsifiers,

optionally one or more co-emulsifiers,

- one or more oil phases

- polidocanol and

- volatile oil.

2. Cosmetic preparation on a nonionic emulsion basis containing polyethylene glycol (12) cetearyl ether, polidocanol and menthol.

3. Cosmetic preparation according to claim 1 with monostearate polyoxyethylene (40) as an O / W emulsifier.

4. Preparation according to claim 1 or 3 with glyceryl stearate as co-emulsifier

5. Preparation according to claim 1, characterized in that the O / W emulsifiers or co-emulsifiers are selected from the group of ethoxylated fatty alcohols, ethoxylated stearates and / or glycerol esters.

6. Preparation according to one of the preceding claims with menthol as an essential oil.

7. Preparation according to one of the preceding claims, characterized in that polidocanol in a proportion of 0.01 to 20 wt.%, In particular from 1 to 10 wt.%, And / or the essential oils individually or in combination in a proportion of 0.001 to 10% by weight, in particular 0.01 to 1% by weight, are used in the preparation.

8. Preparation according to one of the preceding claims with an oil phase content of 1 to 50% by weight, in particular 1 to 40% by weight, based on the mass of the total preparation.

9. Preparation according to one of the preceding claims, characterized in that it additionally contains Spitzwegericht tincture.

10. Preparations according to claims 1 to 9, characterized in that polyols such as in particular glycerol, sorbitol, urea and / or butylene glycol are added as moisturizers.

11. Preparation according to one of the preceding claims, characterized in that customary cosmetic or dermatological auxiliaries, such as dyes, pigments, powder materials, hydrophilic and / or lipophilic active ingredients, deodorants, light stabilizers and / or other auxiliaries are added.

12. Preparation according to claim 11, characterized in that active substances selected from the group consisting of antioxidants, NO synthase inhibitors, catechins, bile esters, flavones, flavonoids, ubiquinones, plastoquinones, creatines, creatine derivatives and / or repellents are added.

13. Preparation according to claim 12, characterized in that the preparation contains coenzyme Q10.

14. Preparation according to claim 11, characterized in that light protection filter substances which absorb UV-A and / or UV-B radiation are added.

15. Drug delivery system containing a preparation according to one of the preceding claims.

16Use of cosmetic or dermatological preparations according to one of the claims as an itch-relieving cream, lotion, gel, spray and / or foam.

17 Use of cosmetic or dermatological preparations according to one of the claims in DDS and / or impregnated wipes.