WO2003038093A3 - Regulation de la l-serine deshydratase humaine - Google Patents

Regulation de la l-serine deshydratase humaine Download PDF

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Publication number
WO2003038093A3
WO2003038093A3 PCT/EP2002/012108 EP0212108W WO03038093A3 WO 2003038093 A3 WO2003038093 A3 WO 2003038093A3 EP 0212108 W EP0212108 W EP 0212108W WO 03038093 A3 WO03038093 A3 WO 03038093A3
Authority
WO
WIPO (PCT)
Prior art keywords
human
serine dehydratase
regulation
reagents
serine
Prior art date
Application number
PCT/EP2002/012108
Other languages
English (en)
Other versions
WO2003038093A2 (fr
Inventor
Yonghong Xiao
Original Assignee
Bayer Ag
Yonghong Xiao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Yonghong Xiao filed Critical Bayer Ag
Publication of WO2003038093A2 publication Critical patent/WO2003038093A2/fr
Publication of WO2003038093A3 publication Critical patent/WO2003038093A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Des réactifs qui régulent la L-sérine déshydratase humaine et des réactifs qui se lient aux produits géniques de la L-sérine déshydratase humaine peuvent jouer un rôle dans la prévention, l'amélioration ou la correction de dysfonctionnements ou de maladies telles que, sans limitation, le cancer et le diabète.
PCT/EP2002/012108 2001-10-30 2002-10-30 Regulation de la l-serine deshydratase humaine WO2003038093A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US33073901P 2001-10-30 2001-10-30
US60/330,739 2001-10-30
US33144801P 2001-11-16 2001-11-16
US60/331,448 2001-11-16
US33866101P 2001-12-11 2001-12-11
US60/338,661 2001-12-11

Publications (2)

Publication Number Publication Date
WO2003038093A2 WO2003038093A2 (fr) 2003-05-08
WO2003038093A3 true WO2003038093A3 (fr) 2003-11-20

Family

ID=27406749

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/012108 WO2003038093A2 (fr) 2001-10-30 2002-10-30 Regulation de la l-serine deshydratase humaine

Country Status (1)

Country Link
WO (1) WO2003038093A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001053312A1 (fr) * 1999-12-23 2001-07-26 Hyseq, Inc. Nouveaux acides nucleiques et polypeptides
US6277619B1 (en) * 1998-06-01 2001-08-21 Incyte Genomics, Inc. Serine dehydratase homolog
WO2001081559A2 (fr) * 2000-04-26 2001-11-01 Millennium Pharmaceuticals, Inc. 26335, serine/threonine dehydratase humaine et ses utilisations

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277619B1 (en) * 1998-06-01 2001-08-21 Incyte Genomics, Inc. Serine dehydratase homolog
WO2001053312A1 (fr) * 1999-12-23 2001-07-26 Hyseq, Inc. Nouveaux acides nucleiques et polypeptides
WO2001081559A2 (fr) * 2000-04-26 2001-11-01 Millennium Pharmaceuticals, Inc. 26335, serine/threonine dehydratase humaine et ses utilisations
EP1285060A2 (fr) * 2000-04-26 2003-02-26 Millennium Pharmaceuticals, Inc. 26335, serine/threonine dehydratase humaine et ses utilisations

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 7 July 2001 (2001-07-07), STRAUSBERG R: "Homo sapiens, clone MGC:15400 IMAGE:4040570, MRNA, COMPLETE CDS", XP002187910, Database accession no. BC009849 *
DATABASE EMBL [online] Database accession no. AAI57992 *
DATABASE EMBL [online] Database accession no. AAM38836 *
DATABASE EMBL [online] XP002187907, Database accession no. y00752 *
DATABASE EMBL [online] XP002187908, Database accession no. J05037 *
NODA C ET AL: "PRIMARY STRUCTURE OF RAT LIVER SERINE DEHYDRATASE DEDUCED FROM THE COMPLEMENTARY DNA SEQUENCE", 1988, FEBS (FEDERATION OF EUROPEAN BIOCHEMICAL SOCIETIES) LETTERS, VOL. 234, NR. 2, PAGE(S) 331-335, ISSN: 0014-5793, XP002255243 *
OGAWA H ET AL: "HUMAN LIVER SERINE DEHYDRATASE CDNA CLONING AND SEQUENCE HOMOLOGY WITH HYDROXYAMINO ACID DEHYDRATASES FROM OTHER SOURCES", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, VOL. 264, NR. 7, PAGE(S) 15818-15823, ISSN: 0021-9258, XP001027779 *

Also Published As

Publication number Publication date
WO2003038093A2 (fr) 2003-05-08

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