WO2003029446A3 - Methods for producing in-vitro hollow organs - Google Patents

Methods for producing in-vitro hollow organs Download PDF

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Publication number
WO2003029446A3
WO2003029446A3 PCT/EP2002/010605 EP0210605W WO03029446A3 WO 2003029446 A3 WO2003029446 A3 WO 2003029446A3 EP 0210605 W EP0210605 W EP 0210605W WO 03029446 A3 WO03029446 A3 WO 03029446A3
Authority
WO
WIPO (PCT)
Prior art keywords
vitro
hollow organs
methods
producing
human
Prior art date
Application number
PCT/EP2002/010605
Other languages
German (de)
French (fr)
Other versions
WO2003029446A2 (en
Inventor
Birgit Schaefer
Stefan Carl
Christian Lorenz
Karl-Herbert Schaefer
Original Assignee
Cytonet Gmgh & Co Kg
Birgit Schaefer
Stefan Carl
Christian Lorenz
Karl-Herbert Schaefer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytonet Gmgh & Co Kg, Birgit Schaefer, Stefan Carl, Christian Lorenz, Karl-Herbert Schaefer filed Critical Cytonet Gmgh & Co Kg
Publication of WO2003029446A2 publication Critical patent/WO2003029446A2/en
Publication of WO2003029446A3 publication Critical patent/WO2003029446A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/383—Nerve cells, e.g. dendritic cells, Schwann cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Prostheses (AREA)

Abstract

The invention relates to methods for producing animal and human in-vitro tissue and/or animal and human in-vitro hollow organs, particularly in-vitro urethra, in-vitro ureter, in-vitro bladder, in-vitro spermatic duct, in-vitro uterine tube, in-vitro blood vessel, in-vitro small intestine, and in-vitro large intestine hollow organs. The invention also relates to the use of this in-vitro tissue and to in-vitro hollow organs for transplantation or for testing purposes, and to the production of a matrix, which is colonized by fibroblasts and provided for the surgical elimination and/or covering of fistulae.
PCT/EP2002/010605 2001-09-24 2002-09-20 Methods for producing in-vitro hollow organs WO2003029446A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10146903A DE10146903C1 (en) 2001-09-24 2001-09-24 In vitro preparation of tissue and organs, useful as grafts for repairing defects and for testing compounds, by seeding matrix that is treated to improve cellular adhesion
DE10146903.9 2001-09-24

Publications (2)

Publication Number Publication Date
WO2003029446A2 WO2003029446A2 (en) 2003-04-10
WO2003029446A3 true WO2003029446A3 (en) 2003-09-12

Family

ID=7700019

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/010605 WO2003029446A2 (en) 2001-09-24 2002-09-20 Methods for producing in-vitro hollow organs

Country Status (2)

Country Link
DE (1) DE10146903C1 (en)
WO (1) WO2003029446A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004025080B4 (en) * 2003-06-23 2007-05-03 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Multicellular test systems
EP1747264B1 (en) 2004-05-21 2012-09-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Multicellular tissue and organ culture systems

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006445A1 (en) * 1996-08-16 1998-02-19 Children's Medical Center Corporation Bladder submucosa seeded with cells for tissue reconstruction
WO1998010775A1 (en) * 1996-09-16 1998-03-19 Purdue Research Foundation Composition and method for repairing neurological tissue
WO1999000152A2 (en) * 1997-06-27 1999-01-07 Augustinus Bader Biosynthetic transplant and method for the production thereof
WO2000066036A2 (en) * 1999-04-30 2000-11-09 Massachusetts General Hospital Fabrication of vascularized tissue using microfabricated two-dimensional molds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006445A1 (en) * 1996-08-16 1998-02-19 Children's Medical Center Corporation Bladder submucosa seeded with cells for tissue reconstruction
WO1998010775A1 (en) * 1996-09-16 1998-03-19 Purdue Research Foundation Composition and method for repairing neurological tissue
WO1999000152A2 (en) * 1997-06-27 1999-01-07 Augustinus Bader Biosynthetic transplant and method for the production thereof
WO2000066036A2 (en) * 1999-04-30 2000-11-09 Massachusetts General Hospital Fabrication of vascularized tissue using microfabricated two-dimensional molds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCHAEFER BIRGIT M ET AL: "Autologous transplantation of urothelium into demucosalized gastrointestinal segments: Evidence for epithelialization and differentiation of in vitro expanded and transplanted urothelial cells.", JOURNAL OF UROLOGY, vol. 159, no. 1, January 1998 (1998-01-01), pages 284 - 290, XP008016529, ISSN: 0022-5347 *

Also Published As

Publication number Publication date
WO2003029446A2 (en) 2003-04-10
DE10146903C1 (en) 2002-11-14

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