WO2003022330A2 - Microneedle-based pen device for drug delivery and method for using same - Google Patents
Microneedle-based pen device for drug delivery and method for using same Download PDFInfo
- Publication number
- WO2003022330A2 WO2003022330A2 PCT/US2002/028785 US0228785W WO03022330A2 WO 2003022330 A2 WO2003022330 A2 WO 2003022330A2 US 0228785 W US0228785 W US 0228785W WO 03022330 A2 WO03022330 A2 WO 03022330A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- microneedle
- delivery device
- substance
- contact surface
- delivery
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
- A61M5/288—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3295—Multiple needle devices, e.g. a plurality of needles arranged coaxially or in parallel
- A61M5/3298—Needles arranged in parallel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/31568—Means keeping track of the total dose administered, e.g. since the cartridge was inserted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
- A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES02798202T ES2393282T3 (en) | 2001-09-12 | 2002-09-11 | Micro-needle based pen device for drug administration |
CA2460063A CA2460063C (en) | 2001-09-12 | 2002-09-11 | Microneedle-based pen device for drug delivery and method for using same |
AU2002333554A AU2002333554C1 (en) | 2001-09-12 | 2002-09-11 | Microneedle-based pen device for drug delivery and method for using same |
EP02798202A EP1432466B1 (en) | 2001-09-12 | 2002-09-11 | Microneedle-based pen device for drug delivery and method for using same |
DK02798202.4T DK1432466T3 (en) | 2001-09-12 | 2002-09-11 | Micro needle-based pen dispenser for drug delivery and method of use thereof |
CNB028207556A CN100349629C (en) | 2001-09-12 | 2002-09-11 | Microneedle-based pen device for drug delivery and method for using same |
BRPI0212496A BRPI0212496B8 (en) | 2001-09-12 | 2002-09-11 | micro-needle-based pen-type device for drug delivery and method of use |
MXPA04002283A MXPA04002283A (en) | 2001-09-12 | 2002-09-11 | Microneedle-based pen device for drug delivery and method for using same. |
JP2003526457A JP4383168B2 (en) | 2001-09-12 | 2002-09-11 | Microneedle administration device and drug administration device |
ZA2004/01969A ZA200401969B (en) | 2001-09-12 | 2004-03-11 | Microneedle based pen device for drug delivery and method for using same |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31888601P | 2001-09-12 | 2001-09-12 | |
US31891301P | 2001-09-12 | 2001-09-12 | |
US60/318,913 | 2001-09-12 | ||
US60/318,886 | 2001-09-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003022330A2 true WO2003022330A2 (en) | 2003-03-20 |
WO2003022330A3 WO2003022330A3 (en) | 2004-01-22 |
Family
ID=26981723
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/028785 WO2003022330A2 (en) | 2001-09-12 | 2002-09-11 | Microneedle-based pen device for drug delivery and method for using same |
Country Status (12)
Country | Link |
---|---|
US (3) | US7556615B2 (en) |
EP (1) | EP1432466B1 (en) |
JP (1) | JP4383168B2 (en) |
CN (1) | CN100349629C (en) |
AU (1) | AU2002333554C1 (en) |
BR (1) | BRPI0212496B8 (en) |
CA (1) | CA2460063C (en) |
DK (1) | DK1432466T3 (en) |
ES (1) | ES2393282T3 (en) |
MX (1) | MXPA04002283A (en) |
WO (1) | WO2003022330A2 (en) |
ZA (1) | ZA200401969B (en) |
Cited By (13)
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EP1596910A2 (en) * | 2003-01-30 | 2005-11-23 | Becton, Dickinson and Company, Wagner, Jaconda | Intradermal delivery device with contoured skin engaging surface geometry |
WO2006030201A1 (en) | 2004-09-13 | 2006-03-23 | Microsample Ltd. | Method and apparatus for sampling and analysis of fluids |
JP2007503866A (en) * | 2003-08-28 | 2007-03-01 | ベクトン・ディキンソン・アンド・カンパニー | Intradermal injection device |
JP2007517768A (en) * | 2003-05-06 | 2007-07-05 | ベクトン・ディキンソン・アンド・カンパニー | How to change the pharmacokinetics of insulin |
WO2010086380A1 (en) | 2009-01-30 | 2010-08-05 | Pronota N.V. | Biomarker for diagnosis, prediction and/or prognosis of acute heart failure and uses thereof |
WO2011048168A1 (en) | 2009-10-21 | 2011-04-28 | Pronota N.V. | Biomarker for diagnosis, prediction and/or prognosis of acute heart failure and uses thereof |
WO2011128357A2 (en) | 2010-04-13 | 2011-10-20 | Pronota N.V. | Biomarkers for hypertensive disorders of pregnancy |
EP2338551A3 (en) * | 2008-06-06 | 2011-11-16 | Wockhardt Limited | A device and a system for delivery of biological material |
CN102596294A (en) * | 2010-03-10 | 2012-07-18 | 泰尔茂株式会社 | Injection needle assembly and drug injection apparatus |
CN102596295A (en) * | 2010-03-10 | 2012-07-18 | 泰尔茂株式会社 | Injection needle assembly and drug injection apparatus |
DE102011119203A1 (en) * | 2011-11-16 | 2013-05-16 | Lts Lohmann Therapie-Systeme Ag | Cylinder-piston unit with short cannula |
US8961460B2 (en) | 2009-09-30 | 2015-02-24 | Terumo Kabushiki Kaisha | Syringe needle assembly and medication injection device |
EP2924439A1 (en) | 2010-03-26 | 2015-09-30 | Mycartis N.V. | Ltbp2 as a biomarker for predicting or prognosticating mortality |
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US7244827B2 (en) * | 2000-04-12 | 2007-07-17 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 24P4C12 useful in treatment and detection of cancer |
JP4083425B2 (en) * | 2001-01-25 | 2008-04-30 | テルモ株式会社 | Liquid injection needle and liquid injection device |
US20050010193A1 (en) * | 2002-05-06 | 2005-01-13 | Laurent Philippe E. | Novel methods for administration of drugs and devices useful thereof |
JP4383168B2 (en) * | 2001-09-12 | 2009-12-16 | ベクトン・ディキンソン・アンド・カンパニー | Microneedle administration device and drug administration device |
JP3933058B2 (en) * | 2002-02-25 | 2007-06-20 | 日立化成工業株式会社 | Support unit for microfluidic system and method for manufacturing the same |
US9486581B2 (en) * | 2002-09-11 | 2016-11-08 | Becton, Dickinson And Company | Injector device with force lock-out and injection rate limiting mechanisms |
US7998119B2 (en) * | 2003-11-18 | 2011-08-16 | Nano Pass Technologies Ltd. | System and method for delivering fluid into flexible biological barrier |
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CA2562643A1 (en) * | 2004-04-12 | 2005-11-24 | Allergan, Inc. | Multi-site injection system |
ATE504328T1 (en) | 2004-11-18 | 2011-04-15 | 3M Innovative Properties Co | MICRONEEDLE ARRANGEMENT APPLICATOR AND HOLDER |
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JP5301985B2 (en) | 2005-04-07 | 2013-09-25 | スリーエム イノベイティブ プロパティズ カンパニー | System and method for tool feedback sensing |
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US20080009802A1 (en) * | 2005-04-25 | 2008-01-10 | Danilo Lambino | Method of treating acne with stratum corneum piercing device |
US20070270738A1 (en) * | 2005-04-25 | 2007-11-22 | Wu Jeffrey M | Method of treating ACNE with stratum corneum piercing patch |
US20080195035A1 (en) | 2005-06-24 | 2008-08-14 | Frederickson Franklyn L | Collapsible Patch and Method of Application |
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US9486581B2 (en) * | 2002-09-11 | 2016-11-08 | Becton, Dickinson And Company | Injector device with force lock-out and injection rate limiting mechanisms |
EP1633417B1 (en) | 2003-05-30 | 2007-01-31 | Eli Lilly And Company | Multiple chamber medication dispensing apparatus |
CA2535138C (en) * | 2003-08-12 | 2013-01-08 | Becton, Dickinson And Company | Patch-like infusion device |
WO2005025641A2 (en) | 2003-08-28 | 2005-03-24 | Becton, Dickinson And Company | Intradermal injection device |
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- 2002-09-11 BR BRPI0212496A patent/BRPI0212496B8/en not_active IP Right Cessation
- 2002-09-11 WO PCT/US2002/028785 patent/WO2003022330A2/en active Application Filing
- 2002-09-11 CN CNB028207556A patent/CN100349629C/en not_active Expired - Lifetime
- 2002-09-11 EP EP02798202A patent/EP1432466B1/en not_active Expired - Lifetime
- 2002-09-11 MX MXPA04002283A patent/MXPA04002283A/en active IP Right Grant
- 2002-09-11 US US10/238,958 patent/US7556615B2/en active Active
- 2002-09-11 AU AU2002333554A patent/AU2002333554C1/en not_active Expired
- 2002-09-11 ES ES02798202T patent/ES2393282T3/en not_active Expired - Lifetime
- 2002-09-11 DK DK02798202.4T patent/DK1432466T3/en active
- 2002-09-11 CA CA2460063A patent/CA2460063C/en not_active Expired - Lifetime
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2004
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2009
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2014
- 2014-10-29 US US14/527,241 patent/US10661066B2/en active Active
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Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1596910A4 (en) * | 2003-01-30 | 2006-12-06 | Becton Dickinson And Company W | Intradermal delivery device with contoured skin engaging surface geometry |
EP1596910A2 (en) * | 2003-01-30 | 2005-11-23 | Becton, Dickinson and Company, Wagner, Jaconda | Intradermal delivery device with contoured skin engaging surface geometry |
US8267890B2 (en) | 2003-01-30 | 2012-09-18 | Becton, Dickinson And Company | Intradermal delivery device with contoured skin engaging surface geometry |
JP2007517768A (en) * | 2003-05-06 | 2007-07-05 | ベクトン・ディキンソン・アンド・カンパニー | How to change the pharmacokinetics of insulin |
JP2007503866A (en) * | 2003-08-28 | 2007-03-01 | ベクトン・ディキンソン・アンド・カンパニー | Intradermal injection device |
US9682198B2 (en) | 2003-08-28 | 2017-06-20 | Becton, Dickinson And Company | Intradermal injection device |
WO2006030201A1 (en) | 2004-09-13 | 2006-03-23 | Microsample Ltd. | Method and apparatus for sampling and analysis of fluids |
US8092394B2 (en) | 2004-09-13 | 2012-01-10 | Microsample Ltd. | Method and apparatus for sampling and analysis of fluids |
EP2338551A3 (en) * | 2008-06-06 | 2011-11-16 | Wockhardt Limited | A device and a system for delivery of biological material |
WO2010086380A1 (en) | 2009-01-30 | 2010-08-05 | Pronota N.V. | Biomarker for diagnosis, prediction and/or prognosis of acute heart failure and uses thereof |
US8961460B2 (en) | 2009-09-30 | 2015-02-24 | Terumo Kabushiki Kaisha | Syringe needle assembly and medication injection device |
WO2011048173A1 (en) | 2009-10-21 | 2011-04-28 | Pronota N.V. | Mcam as a biomarker for fluid homeostasis |
WO2011048168A1 (en) | 2009-10-21 | 2011-04-28 | Pronota N.V. | Biomarker for diagnosis, prediction and/or prognosis of acute heart failure and uses thereof |
CN102596294A (en) * | 2010-03-10 | 2012-07-18 | 泰尔茂株式会社 | Injection needle assembly and drug injection apparatus |
CN102596295A (en) * | 2010-03-10 | 2012-07-18 | 泰尔茂株式会社 | Injection needle assembly and drug injection apparatus |
US9283330B2 (en) | 2010-03-10 | 2016-03-15 | Terumo Kabushiki Kaisha | Injection needle assembly and drug injection apparatus |
US9381310B2 (en) | 2010-03-10 | 2016-07-05 | Terumo Kabushiki Kaisha | Injection needle assembly and drug injection apparatus |
EP2924439A1 (en) | 2010-03-26 | 2015-09-30 | Mycartis N.V. | Ltbp2 as a biomarker for predicting or prognosticating mortality |
WO2011128357A2 (en) | 2010-04-13 | 2011-10-20 | Pronota N.V. | Biomarkers for hypertensive disorders of pregnancy |
DE102011119203A1 (en) * | 2011-11-16 | 2013-05-16 | Lts Lohmann Therapie-Systeme Ag | Cylinder-piston unit with short cannula |
Also Published As
Publication number | Publication date |
---|---|
CA2460063C (en) | 2010-07-20 |
WO2003022330A3 (en) | 2004-01-22 |
EP1432466A2 (en) | 2004-06-30 |
BR0212496A (en) | 2004-08-24 |
US10661066B2 (en) | 2020-05-26 |
US20030050602A1 (en) | 2003-03-13 |
BR0212496B1 (en) | 2014-10-21 |
EP1432466A4 (en) | 2010-04-14 |
JP4383168B2 (en) | 2009-12-16 |
AU2002333554B2 (en) | 2008-09-04 |
CA2460063A1 (en) | 2003-03-20 |
US20150051582A1 (en) | 2015-02-19 |
CN100349629C (en) | 2007-11-21 |
CN1571685A (en) | 2005-01-26 |
JP2005527249A (en) | 2005-09-15 |
ZA200401969B (en) | 2005-07-27 |
BRPI0212496B8 (en) | 2021-06-22 |
EP1432466B1 (en) | 2012-08-15 |
ES2393282T3 (en) | 2012-12-20 |
DK1432466T3 (en) | 2012-12-03 |
AU2002333554C1 (en) | 2008-12-11 |
US20090157041A1 (en) | 2009-06-18 |
MXPA04002283A (en) | 2004-06-29 |
US8900186B2 (en) | 2014-12-02 |
US7556615B2 (en) | 2009-07-07 |
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