WO2003022260B1 - Utilisation de methotrexate et de l-arginine pour preparer un medicament servant a traiter des myomes uterins - Google Patents

Utilisation de methotrexate et de l-arginine pour preparer un medicament servant a traiter des myomes uterins

Info

Publication number
WO2003022260B1
WO2003022260B1 PCT/YU2002/000017 YU0200017W WO03022260B1 WO 2003022260 B1 WO2003022260 B1 WO 2003022260B1 YU 0200017 W YU0200017 W YU 0200017W WO 03022260 B1 WO03022260 B1 WO 03022260B1
Authority
WO
WIPO (PCT)
Prior art keywords
myoma
methotrexate
arginine
mixture
drug
Prior art date
Application number
PCT/YU2002/000017
Other languages
English (en)
Other versions
WO2003022260A1 (fr
Inventor
Slobodan Arsenijevic
Zoran Matovic
Original Assignee
Slobodan Arsenijevic
Zoran Matovic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Slobodan Arsenijevic, Zoran Matovic filed Critical Slobodan Arsenijevic
Publication of WO2003022260A1 publication Critical patent/WO2003022260A1/fr
Publication of WO2003022260B1 publication Critical patent/WO2003022260B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un médicament pour traiter des myomes de l'utérus, qui permet de protéger des propriétés biologiques et sexuelles chez la femme et qui n'induit aucune contre-indication associée à d'autres méthodes de traitement connues. Cette invention est représentée par un mélange de deux substances, le méthotrexate et la L-arginine. Le médicament pour traiter des myomes de l'utérus selon cette invention est composé de 5 g de méthotrexate, de 10 g de L-arginine et de 985 cm3 d'eau. La combinaison de ces deux substances dans une solution aqueuse fournit un mélange homogène dans lequel chaque composant conserve son identité chimique. Ledit médicament est appliqué le huitième jour de la phase folliculaire du cycle menstruel de patientes présentant des myomes de l'utérus. La patiente est mise en position de lithotomie, le spéculum vaginal est mis en place et le col de l'utérus est tiré à l'aide d'une pince à rouleau de façon à exposer le col de l'utérus externe. L'emballage est ouvert, l'aiguille de ponction est insérée dans le canal du col utérin et est dirigée en direction du myomètre, vers le côté où se trouve le myome. L'aiguille est poussée à travers l'endomètre, à une profondeur de 1 cm. Il est nécessaire de s'assurer que l'injection du médicament ait lieu à 1 cm de profondeur, afin d'éviter une éventuelle pénétration à travers la paroi utérine. Il faut aspirer afin de vérifier que l'aiguille ne se trouve pas dans un vaisseau sanguin et d'injecter lentement le médicament. La seringue et l'aiguille sont jetées après usage. Le mélange est appliqué sur trois cycles menstruels consécutifs. La méthode est simple, peut être pratiquée en consultation externe par un gynécologue, aucun guidage par échographie n'est nécessaire et l'approche transvaginale et transcervicale est mise en oeuvre. Ledit mélange induit le processus d'apoptose (mort cellulaire programmée), de façon à provoquer une nécrose, une dégénérescence ou une inflammation si toutes les mesures de précaution d'antisepsie sont respectées. On constate une réduction radicale à la fois de la perte de sang au cours des règles chez des femmes présentant un myome et du volume du myome. La dose appliquée étant très faible, la toxicité est négligeable. L'application de ce mélange conduit progressivement à la ménopause, sans perturber l'axe hypothalamo-hypophyso-gonadique. L'application de ce mélange n'induit aucune complication précoce ou tardive, spécifique à d'autres approches médicales dont la liste est donnée dans la partie contexte de l'invention. Après traitement avec ce médicament, le volume des myomes est réduit de 20-30%, aucune ablation chirurgicale n'est nécessaire, les myomes ne se développent plus et le volume des saignements menstruels devient normal.
PCT/YU2002/000017 2001-09-12 2002-09-10 Utilisation de methotrexate et de l-arginine pour preparer un medicament servant a traiter des myomes uterins WO2003022260A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
YUP065701 2001-09-12
YUP-657/01 2001-09-12

Publications (2)

Publication Number Publication Date
WO2003022260A1 WO2003022260A1 (fr) 2003-03-20
WO2003022260B1 true WO2003022260B1 (fr) 2003-10-16

Family

ID=25550874

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/YU2002/000017 WO2003022260A1 (fr) 2001-09-12 2002-09-10 Utilisation de methotrexate et de l-arginine pour preparer un medicament servant a traiter des myomes uterins

Country Status (1)

Country Link
WO (1) WO2003022260A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8118728B2 (en) 2000-10-12 2012-02-21 Coloplast A/S Method for implanting an adjustable surgical implant for treating urinary incontinence
US8128554B2 (en) 2000-10-12 2012-03-06 Coloplast A/S System for introducing a pelvic implant
US8157821B2 (en) 2001-03-30 2012-04-17 Coloplast A/S Surgical implant
US8215310B2 (en) 2004-05-21 2012-07-10 Coloplast A/S Implant for treatment of vaginal and/or uterine prolapse
US8668635B2 (en) 2000-10-12 2014-03-11 Coloplast A/S Pelvic implant with suspending system
US8920304B2 (en) 2000-07-05 2014-12-30 Coloplast A/S Method and device for treating urinary incontinence
US9005222B2 (en) 2002-08-02 2015-04-14 Coloplast A/S Self-anchoring sling and introducer system
US9186489B2 (en) 2003-03-27 2015-11-17 Coloplast A/S Implantable delivery device system for delivery of a medicament to a bladder

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE040045T2 (hu) 2009-01-29 2019-02-28 Fondazione Irccs Istituto Naz Dei Tumori Méhnyakon belüli eszköz gyógyszerek felszabadítására a méhnyakrák lokoregionális kezelésében

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3513938A1 (de) * 1985-04-18 1986-10-23 Merck Patent Gmbh, 6100 Darmstadt Cytostatikahaltiges pharmakadepot
JP2827287B2 (ja) * 1988-07-05 1998-11-25 武田薬品工業株式会社 水溶性薬物含有徐放型マイクロカプセル

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US8920304B2 (en) 2000-07-05 2014-12-30 Coloplast A/S Method and device for treating urinary incontinence
US10278800B2 (en) 2000-07-05 2019-05-07 Coloplast A/S Method and device for treating urinary incontinence
US8821369B2 (en) 2000-10-12 2014-09-02 Colorplast A/S Method for soft tissue anchoring with introducer
US9113992B2 (en) 2000-10-12 2015-08-25 Coloplast A/S Apparatus and method for treating urinary incontinence
US8118727B2 (en) 2000-10-12 2012-02-21 Coloplast A/S Method for supporting pelvic anatomy
US8852075B2 (en) 2000-10-12 2014-10-07 Coloplast A/S Pelvic implant systems and methods with expandable anchors
US8162818B2 (en) 2000-10-12 2012-04-24 Coloplast A/S Adjustable surgical implant for pelvic anatomy
US8182413B2 (en) 2000-10-12 2012-05-22 Coloplast A/S Method for fibrous anchoring of a pelvic support
US8182412B2 (en) 2000-10-12 2012-05-22 Coloplast A/S Pelvic implant with fibrous anchor
US8118728B2 (en) 2000-10-12 2012-02-21 Coloplast A/S Method for implanting an adjustable surgical implant for treating urinary incontinence
US8273011B2 (en) 2000-10-12 2012-09-25 Coloplast A/S Adjustable surgical implant and method for treating urinary incontinence
US8449450B2 (en) 2000-10-12 2013-05-28 Coloplast A/S Pass through introducer and sling
US8454492B2 (en) 2000-10-12 2013-06-04 Coloplast A/S Absorbable anchor and method for mounting mesh to tissue
US8469877B2 (en) 2000-10-12 2013-06-25 Coloplast A/S System for introducing a pelvic implant
US8512223B2 (en) 2000-10-12 2013-08-20 Coloplast A/S Pelvic implant with selective locking anchor
US8574148B2 (en) 2000-10-12 2013-11-05 Coloplast A/S System for introducing soft tissue anchors
US9918817B2 (en) 2000-10-12 2018-03-20 Coloplast A/S Method of post-operatively adjusting a urethral support in treating urinary incontinence of a woman
US8888678B2 (en) 2000-10-12 2014-11-18 Coloplast A/S Pelvic implant with suspending system
US8128554B2 (en) 2000-10-12 2012-03-06 Coloplast A/S System for introducing a pelvic implant
US8668635B2 (en) 2000-10-12 2014-03-11 Coloplast A/S Pelvic implant with suspending system
US8801596B2 (en) 2000-10-12 2014-08-12 Coloplast A/S Sling with support and suspending members formed from same polymer
US8821370B2 (en) 2000-10-12 2014-09-02 Coloplast A/S Device, system and methods for introducing soft tissue anchors
US9968430B2 (en) 2000-10-12 2018-05-15 Coloplast A/S Surgical device implantable to treat female urinary incontinence
US9089396B2 (en) 2000-10-12 2015-07-28 Coloplast A/S Urinary incontinence treatment and devices
US9089394B2 (en) 2000-10-12 2015-07-28 Coloplast A/S Pelvic implant with suspending system
US8911347B2 (en) 2000-10-12 2014-12-16 Coloplast A/S System and method for treating urinary incontinence
US8123673B2 (en) 2000-10-12 2012-02-28 Coloplast A/S Adjustable surgical implant for treating urinary incontinence
US8920308B2 (en) 2000-10-12 2014-12-30 Coloplast A/S Surgical implant with anchor introducer channel
US8932202B2 (en) 2000-10-12 2015-01-13 Coloplast A/S Incontinence implant with soft tissue anchors and length not allowing abdominal wall penetration
US8157822B2 (en) 2001-03-30 2012-04-17 Coloplast A/S Surgical implant and methods of use
US8632554B2 (en) 2001-03-30 2014-01-21 Coloplast A/S Low mass density surgical implant having strands and methods of use
US8603120B2 (en) 2001-03-30 2013-12-10 Coloplast A/S Low mass density surgical implant and methods of use
US8157821B2 (en) 2001-03-30 2012-04-17 Coloplast A/S Surgical implant
US9943390B2 (en) 2001-03-30 2018-04-17 Coloplast A/S Method of treating pelvic organ prolapse in a female patient by accessing a prolapsed organ trans-vaginally through a vagina
US8603119B2 (en) 2001-03-30 2013-12-10 Coloplast A/S Surgical implant having strands and methods of use
US9248011B2 (en) 2001-03-30 2016-02-02 Coloplast A/S Surgical implant and methods of use
US9532861B2 (en) 2002-08-02 2017-01-03 Coloplast A/S Self-anchoring sling and introducer system
US9872750B2 (en) 2002-08-02 2018-01-23 Coloplast A/S Self-anchoring sling and introducer system
US9005222B2 (en) 2002-08-02 2015-04-14 Coloplast A/S Self-anchoring sling and introducer system
US9532862B2 (en) 2002-08-02 2017-01-03 Coloplast A/S Self-anchoring sling and introducer system
US9345867B2 (en) 2003-03-27 2016-05-24 Coloplast A/S Device implantable in tissue of a prostate gland or a bladder
US9555168B2 (en) 2003-03-27 2017-01-31 Coloplast A/S System for delivery of medication in treatment of disorders of the pelvis
US9186489B2 (en) 2003-03-27 2015-11-17 Coloplast A/S Implantable delivery device system for delivery of a medicament to a bladder
US9060838B2 (en) 2004-05-21 2015-06-23 Coloplast A/S Tissue supported implantable device
US8215310B2 (en) 2004-05-21 2012-07-10 Coloplast A/S Implant for treatment of vaginal and/or uterine prolapse

Also Published As

Publication number Publication date
WO2003022260A1 (fr) 2003-03-20

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