WO2003020719A1 - Derives de 1,3-benzothiazinone et leur utilisation - Google Patents

Derives de 1,3-benzothiazinone et leur utilisation Download PDF

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Publication number
WO2003020719A1
WO2003020719A1 PCT/JP2002/008866 JP0208866W WO03020719A1 WO 2003020719 A1 WO2003020719 A1 WO 2003020719A1 JP 0208866 W JP0208866 W JP 0208866W WO 03020719 A1 WO03020719 A1 WO 03020719A1
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
optionally substituted
general formula
compounds
pirazinyl
Prior art date
Application number
PCT/JP2002/008866
Other languages
English (en)
French (fr)
Inventor
Masahiro Kajino
Akira Kawada
Yutaka Nakayama
Haruhide Kimura
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Priority to CA2459224A priority Critical patent/CA2459224C/en
Priority to US10/488,384 priority patent/US7399759B2/en
Priority to EP02762953A priority patent/EP1424336A4/en
Publication of WO2003020719A1 publication Critical patent/WO2003020719A1/ja
Priority to US12/099,779 priority patent/US7767665B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
PCT/JP2002/008866 2001-09-03 2002-09-02 Derives de 1,3-benzothiazinone et leur utilisation WO2003020719A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA2459224A CA2459224C (en) 2001-09-03 2002-09-02 1,3-benzothiazinone derivatives and the use thereof
US10/488,384 US7399759B2 (en) 2001-09-03 2002-09-02 1, 3-benzothiazinone derivatives and use thereof
EP02762953A EP1424336A4 (en) 2001-09-03 2002-09-02 1,3-BENZOTHIAZINE DERIVATIVES AND THEIR USE
US12/099,779 US7767665B2 (en) 2001-09-03 2008-04-08 1,3-benzothiazinone derivatives and use thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001265743 2001-09-03
JP2001-265743 2001-09-03
JP2002-180528 2002-06-20
JP2002180528 2002-06-20

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10488384 A-371-Of-International 2002-09-02
US12/099,779 Continuation US7767665B2 (en) 2001-09-03 2008-04-08 1,3-benzothiazinone derivatives and use thereof

Publications (1)

Publication Number Publication Date
WO2003020719A1 true WO2003020719A1 (fr) 2003-03-13

Family

ID=26621530

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/008866 WO2003020719A1 (fr) 2001-09-03 2002-09-02 Derives de 1,3-benzothiazinone et leur utilisation

Country Status (4)

Country Link
US (2) US7399759B2 (ja)
EP (1) EP1424336A4 (ja)
CA (1) CA2459224C (ja)
WO (1) WO2003020719A1 (ja)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003086398A1 (en) * 2002-04-05 2003-10-23 Abbott Laboratories Aminocarbonyl substituted pyridines, pyridazines, pyrimidines, pyrazines and triazines having antiangiogenic activity
WO2003090782A1 (fr) * 2002-04-26 2003-11-06 Takeda Chemical Industries, Ltd. Inhibiteur de la mort cellulaire
WO2004060881A1 (ja) * 2002-12-05 2004-07-22 Takeda Pharmaceutical Company Limited １，３−ベンゾチアジノン誘導体、その製造法および用途
WO2004096199A2 (en) * 2003-05-02 2004-11-11 Scottish Biomedical Limited Regulation of guanine nucleotide exchange factor
WO2006132438A1 (ja) * 2005-06-09 2006-12-14 Takeda Pharmaceutical Company Limited １，３－ベンゾチアジノン誘導体およびその用途
JP2007534624A (ja) * 2003-07-16 2007-11-29 ニューロジェン・コーポレーション ビアリールピペラジニル−ピリジン類縁体
WO2008035823A1 (fr) 2006-09-22 2008-03-27 Takeda Pharmaceutical Company Limited Inhibiteur de mort cellulaire
US7592466B2 (en) 2003-10-09 2009-09-22 Abbott Laboratories Ureas having antiangiogenic activity
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK
US9540322B2 (en) 2008-08-18 2017-01-10 Yale University MIF modulators
US9643922B2 (en) 2008-08-18 2017-05-09 Yale University MIF modulators
US10011594B2 (en) 2015-06-03 2018-07-03 Bristol-Myers Squibb Company 4-hydroxy-3-(heteroaryl)pyridine-2-one APJ agonists
CN114957235A (zh) * 2021-05-27 2022-08-30 四川大学华西医院 苯并噻嗪酮衍生物及其制备方法和用途

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY140679A (en) 2001-05-24 2010-01-15 Avanir Pharmaceuticals Inhibitors of macrohage migration inhibitory factor and methods for identifying the same
US7399759B2 (en) * 2001-09-03 2008-07-15 Takeda Pharmaceutical Company Limited 1, 3-benzothiazinone derivatives and use thereof
TW200418829A (en) 2003-02-14 2004-10-01 Avanir Pharmaceutics Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
FR2881427A1 (fr) * 2005-01-31 2006-08-04 Oreal Derives de 3-sulfanylpropanamide, composition les contenant et leur utilisation pour stimuler la pousse des cheveux et des cils et/ou freiner leur chute et/ou limiter leur depigmentation
JP2008534502A (ja) 2005-03-24 2008-08-28 アバニール・ファーマシューティカルズ マクロファージ遊走阻止因子の阻害剤としてのチエノピリジノン誘導体
US8252804B2 (en) * 2008-10-01 2012-08-28 Duquesne University Of The Holy Spirit Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same
US20110082158A1 (en) * 2008-10-01 2011-04-07 Aleem Gangjee Selective proton coupled folate transporter and folate receptor, and garftase and/or other folate metabolizing enzymes inhibitor compounds and methods of using the same
US8114893B2 (en) 2008-12-19 2012-02-14 Genentech, Inc. Compounds and methods of use
ES2533798T3 (es) 2009-10-12 2015-04-14 Bayer Cropscience Ag 1-(pirid-3-il)-pirazol y 1-(pirimid-5-il)- pirazol como agentes para combatir parásitos
CA2921503C (en) * 2013-08-20 2021-08-10 Olatec Therapeutics Llc Pharmaceutical composition and use of diethyl(2-cyanoethyl)phosphonate for the treatment of inflammation or pain
US10336672B2 (en) 2014-08-04 2019-07-02 ClearWaterBay Technology, Inc. System and method for producing neopentyl glycol
CN105384684B (zh) * 2015-12-16 2018-02-13 辽宁工程技术大学 一种2‑氰基‑6‑甲基吡啶的制备方法
EP4110765A4 (en) * 2020-02-28 2024-03-06 Univ Texas INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASES

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002018356A1 (fr) * 2000-08-31 2002-03-07 Takeda Chemical Industries, Ltd. Inhibiteurs de l'apoptose des cellules du muscle cardiaque et agents therapeutiques/prophylactiques contre les maladies cardiaques

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7399759B2 (en) * 2001-09-03 2008-07-15 Takeda Pharmaceutical Company Limited 1, 3-benzothiazinone derivatives and use thereof
WO2003090782A1 (fr) 2002-04-26 2003-11-06 Takeda Chemical Industries, Ltd. Inhibiteur de la mort cellulaire

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002018356A1 (fr) * 2000-08-31 2002-03-07 Takeda Chemical Industries, Ltd. Inhibiteurs de l'apoptose des cellules du muscle cardiaque et agents therapeutiques/prophylactiques contre les maladies cardiaques

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BOLL. SCI. FAC. CHIM. IND., 1987, BOLOGNA, pages 37 - 39 *
CHEMICAL ABSTRACTS, vol. 51, Columbus, Ohio, US; abstract no. 17927G-H, XP002961051 *

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003086398A1 (en) * 2002-04-05 2003-10-23 Abbott Laboratories Aminocarbonyl substituted pyridines, pyridazines, pyrimidines, pyrazines and triazines having antiangiogenic activity
US8173360B2 (en) 2002-04-26 2012-05-08 Takeda Pharmaceutical Company Limited Cell death inhibitor
WO2003090782A1 (fr) * 2002-04-26 2003-11-06 Takeda Chemical Industries, Ltd. Inhibiteur de la mort cellulaire
EP2270505A1 (en) 2002-04-26 2011-01-05 Takeda Pharmaceutical Company Limited A method of screening a cell death inhibitor using macrophage migration inhibitory factor (MIF)
WO2004060881A1 (ja) * 2002-12-05 2004-07-22 Takeda Pharmaceutical Company Limited １，３−ベンゾチアジノン誘導体、その製造法および用途
US7659267B2 (en) 2002-12-05 2010-02-09 Takeda Pharmaceutical Company Limited 1,3-Benzothiazinone derivatives, process for producing the same use thereof
WO2004096199A2 (en) * 2003-05-02 2004-11-11 Scottish Biomedical Limited Regulation of guanine nucleotide exchange factor
WO2004096199A3 (en) * 2003-05-02 2006-03-30 Scottish Biomedical Ltd Regulation of guanine nucleotide exchange factor
JP2007534624A (ja) * 2003-07-16 2007-11-29 ニューロジェン・コーポレーション ビアリールピペラジニル−ピリジン類縁体
US7592466B2 (en) 2003-10-09 2009-09-22 Abbott Laboratories Ureas having antiangiogenic activity
WO2006132438A1 (ja) * 2005-06-09 2006-12-14 Takeda Pharmaceutical Company Limited １，３－ベンゾチアジノン誘導体およびその用途
JP5250419B2 (ja) * 2006-09-22 2013-07-31 武田薬品工業株式会社 細胞死抑制剤
WO2008035823A1 (fr) 2006-09-22 2008-03-27 Takeda Pharmaceutical Company Limited Inhibiteur de mort cellulaire
US9044483B2 (en) 2006-09-22 2015-06-02 Takeda Pharmaceuticals Company Limited Cell death inhibition by macrophage migration inhibitory factor and a binding substance thereto
US9540322B2 (en) 2008-08-18 2017-01-10 Yale University MIF modulators
US9643922B2 (en) 2008-08-18 2017-05-09 Yale University MIF modulators
US10202343B2 (en) 2008-08-18 2019-02-12 Yale University MIF modulators
US11584717B2 (en) 2008-08-18 2023-02-21 Yale University MIF modulators
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK
US10011594B2 (en) 2015-06-03 2018-07-03 Bristol-Myers Squibb Company 4-hydroxy-3-(heteroaryl)pyridine-2-one APJ agonists
US10336739B2 (en) 2015-06-03 2019-07-02 Bristol-Myers Squibb Company 4-hydroxy-3-(heteroaryl)pyridine-2-one APJ agonists
CN114957235A (zh) * 2021-05-27 2022-08-30 四川大学华西医院 苯并噻嗪酮衍生物及其制备方法和用途
CN114957235B (zh) * 2021-05-27 2023-10-24 四川大学华西医院 苯并噻嗪酮衍生物及其制备方法和用途

Also Published As

Publication number Publication date
CA2459224A1 (en) 2003-03-13
US7767665B2 (en) 2010-08-03
US20050032786A1 (en) 2005-02-10
US20090082343A1 (en) 2009-03-26
CA2459224C (en) 2012-05-08
EP1424336A4 (en) 2004-11-10
US7399759B2 (en) 2008-07-15
EP1424336A1 (en) 2004-06-02

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