WO2003019186A3 - Assay for identifying ion channel modulators - Google Patents
Assay for identifying ion channel modulators Download PDFInfo
- Publication number
- WO2003019186A3 WO2003019186A3 PCT/GB2002/003927 GB0203927W WO03019186A3 WO 2003019186 A3 WO2003019186 A3 WO 2003019186A3 GB 0203927 W GB0203927 W GB 0203927W WO 03019186 A3 WO03019186 A3 WO 03019186A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ion channel
- assay
- voltage
- dependence
- target ion
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002326018A AU2002326018A1 (en) | 2001-08-24 | 2002-08-27 | Assay for identifying ion channel modulators |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0120589A GB0120589D0 (en) | 2001-08-24 | 2001-08-24 | Assay |
GB0120589.7 | 2001-08-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003019186A2 WO2003019186A2 (en) | 2003-03-06 |
WO2003019186A3 true WO2003019186A3 (en) | 2003-05-08 |
Family
ID=9920914
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2002/003927 WO2003019186A2 (en) | 2001-08-24 | 2002-08-27 | Assay for identifying ion channel modulators |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2002326018A1 (en) |
GB (1) | GB0120589D0 (en) |
WO (1) | WO2003019186A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2491803A1 (en) * | 2002-06-25 | 2003-12-31 | Serono Genetics Institute S.A. | Novel kcnq polypeptides, modulators thereof, and their uses in the treatment of mental disorders |
US7442519B2 (en) | 2002-06-25 | 2008-10-28 | Serono Genetics Institute, S.A. | KCNQ2-15 potassium channel |
JP2006526389A (en) | 2003-01-07 | 2006-11-24 | ニューロームド テクノロジーズ、インク. | Fluorescent T-type channel assay |
CA2534438A1 (en) * | 2003-07-15 | 2005-02-03 | Chanxpress, Inc. | High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins |
DE102006003177A1 (en) | 2006-01-23 | 2007-08-02 | Siemens Ag | Apparatus and method for detecting an analyte |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998055870A1 (en) * | 1997-06-04 | 1998-12-10 | A+ Science Invest Ab | Detection of biologically active molecules by use of pre-activated cell-based biosensors in liquid-based separation systems |
WO2001033219A2 (en) * | 1999-11-02 | 2001-05-10 | Biofocus Discovery Limited | Ion channel permeability |
-
2001
- 2001-08-24 GB GB0120589A patent/GB0120589D0/en not_active Ceased
-
2002
- 2002-08-27 AU AU2002326018A patent/AU2002326018A1/en not_active Abandoned
- 2002-08-27 WO PCT/GB2002/003927 patent/WO2003019186A2/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998055870A1 (en) * | 1997-06-04 | 1998-12-10 | A+ Science Invest Ab | Detection of biologically active molecules by use of pre-activated cell-based biosensors in liquid-based separation systems |
WO2001033219A2 (en) * | 1999-11-02 | 2001-05-10 | Biofocus Discovery Limited | Ion channel permeability |
Non-Patent Citations (3)
Title |
---|
MAIN M J ET AL: "MODULATION OF KCNQ2/3 POTASSIUM CHANNELS BY THE NOVEL ANTICONVULSANT RETIGABINE", MOLECULAR PHARMACOLOGY, BALTIMORE, MD, US, vol. 58, no. 2, August 2000 (2000-08-01), pages 253 - 262, XP000972245, ISSN: 0026-895X * |
MEADOWS H J ET AL: "FUNCTIONAL CHARACTERISATION OF HUMAN TASK-3, AN ACID-SENSITIVE TWO-PORE DOMAIN POTASSIUM CHANNEL", NEUROPHARMACOLOGY, PERGAMON PRESS, OXFORD, GB, vol. 40, no. 4, March 2001 (2001-03-01), pages 551 - 559, XP000999772, ISSN: 0028-3908 * |
RUKNUDIN A M ET AL: "CHARACTERIZATION OF A HUMAN MINK CHANNEL EXPRESSE IN XENOPUS OOCYTES", SOCIETY FOR NEUROSCIENCE ABSTRACTS, SOCIETY FOR NEUROSCIENCE, US, vol. 19, no. 1-3, 1993, pages 705, XP001022126, ISSN: 0190-5295 * |
Also Published As
Publication number | Publication date |
---|---|
GB0120589D0 (en) | 2001-10-17 |
WO2003019186A2 (en) | 2003-03-06 |
AU2002326018A1 (en) | 2003-03-10 |
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