WO2003016498A3 - Molecular interaction sites of rnase p rna and methods of modulating the same - Google Patents

Molecular interaction sites of rnase p rna and methods of modulating the same Download PDF

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Publication number
WO2003016498A3
WO2003016498A3 PCT/US2002/026418 US0226418W WO03016498A3 WO 2003016498 A3 WO2003016498 A3 WO 2003016498A3 US 0226418 W US0226418 W US 0226418W WO 03016498 A3 WO03016498 A3 WO 03016498A3
Authority
WO
WIPO (PCT)
Prior art keywords
rna
rnase
modulating
methods
same
Prior art date
Application number
PCT/US2002/026418
Other languages
French (fr)
Other versions
WO2003016498A2 (en
Inventor
David J Ecker
Original Assignee
Isis Pharmaceuticals Inc
David J Ecker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc, David J Ecker filed Critical Isis Pharmaceuticals Inc
Priority to EP02768616A priority Critical patent/EP1425292A2/en
Priority to IL16040102A priority patent/IL160401A0/en
Priority to CA002457318A priority patent/CA2457318A1/en
Priority to JP2003521807A priority patent/JP2005503148A/en
Publication of WO2003016498A2 publication Critical patent/WO2003016498A2/en
Publication of WO2003016498A3 publication Critical patent/WO2003016498A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/26—Endoribonucleases producing 5'-phosphomonoesters (3.1.26)
    • C12Y301/26006—Ribonuclease IV (3.1.26.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Polynucleotides comprising molecular interaction sites of RNase P RNA that have particular secondary structure are provided. Methods of using such polynucleotides to screen, virtually or actually, combinatorial libraries of compounds that bind thereto are also provided. Method of modulating the activity of RNase P RNA by contacting RNase P RNA or prokaryotic cells containing the same with a compound identified by such virtual or actual screening are also provided.
PCT/US2002/026418 2001-08-21 2002-08-19 Molecular interaction sites of rnase p rna and methods of modulating the same WO2003016498A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP02768616A EP1425292A2 (en) 2001-08-21 2002-08-19 Molecular interaction sites of rnase p rna and methods of modulating the same
IL16040102A IL160401A0 (en) 2001-08-21 2002-08-19 Molecular interaction sites of rnase p rna and methods of modulating the same
CA002457318A CA2457318A1 (en) 2001-08-21 2002-08-19 Molecular interaction sites of rnase prna and methods of modulating the same
JP2003521807A JP2005503148A (en) 2001-08-21 2002-08-19 Molecular interaction site of RNase PRNA and method for modulating the same site

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31402001P 2001-08-21 2001-08-21
US60/314,020 2001-08-21

Publications (2)

Publication Number Publication Date
WO2003016498A2 WO2003016498A2 (en) 2003-02-27
WO2003016498A3 true WO2003016498A3 (en) 2004-03-11

Family

ID=23218192

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/026418 WO2003016498A2 (en) 2001-08-21 2002-08-19 Molecular interaction sites of rnase p rna and methods of modulating the same

Country Status (5)

Country Link
EP (1) EP1425292A2 (en)
JP (1) JP2005503148A (en)
CA (1) CA2457318A1 (en)
IL (1) IL160401A0 (en)
WO (1) WO2003016498A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7425233B2 (en) 2006-02-16 2008-09-16 Brother Kogyo Kabushiki Kaisha Cyan ink for ink-jet recording

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221587B1 (en) * 1998-05-12 2001-04-24 Isis Pharmceuticals, Inc. Identification of molecular interaction sites in RNA for novel drug discovery

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221587B1 (en) * 1998-05-12 2001-04-24 Isis Pharmceuticals, Inc. Identification of molecular interaction sites in RNA for novel drug discovery

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LAGRANDEUR ET AL.: "Phylogenic comparative chemical footprint analysis of the interaction between ribonuclease P RNA and tRNA", THE EMBO JOURNAL, vol. 13, no. 17, 1994, pages 3945 - 3951, XP002964862 *
MUELLER ET AL.: "A new model for the three-dimensional folding of escherichia coli 16 S ribosomal RNA. I. Fitting the RNA to a 3D election microscopic map at 20 angstroms", JOURNAL OF MOLECULAR BIOLOGY, vol. 271, 1997, pages 524 - 544, XP002964861 *
ODELL ET AL.: "Interaction of structural modules in substrate binding by the ribozyme from bacillus subtilis RNase P", NUCLEIC ACIDS RESEARCH, vol. 26, no. 16, 1998, pages 3717 - 3723, XP002964859 *
WESTHOF ET AL.: "Three-dimensional working model of M1 RNA, the catalytic RNA subunit of ribonuclease P from escherichia coli", PROC. NATL. ACAD. SCI. USA, vol. 91, 1994, pages 5133 - 5137, XP002964860 *

Also Published As

Publication number Publication date
JP2005503148A (en) 2005-02-03
WO2003016498A2 (en) 2003-02-27
CA2457318A1 (en) 2003-02-27
IL160401A0 (en) 2004-07-25
EP1425292A2 (en) 2004-06-09

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