WO2004110386A3 - Molecular interaction sites of coronavirus rna and methods of modulating the same - Google Patents

Molecular interaction sites of coronavirus rna and methods of modulating the same Download PDF

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Publication number
WO2004110386A3
WO2004110386A3 PCT/US2004/019022 US2004019022W WO2004110386A3 WO 2004110386 A3 WO2004110386 A3 WO 2004110386A3 US 2004019022 W US2004019022 W US 2004019022W WO 2004110386 A3 WO2004110386 A3 WO 2004110386A3
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WO
WIPO (PCT)
Prior art keywords
methods
modulating
coronavirus rna
molecular interaction
interaction sites
Prior art date
Application number
PCT/US2004/019022
Other languages
French (fr)
Other versions
WO2004110386A2 (en
Inventor
Steven A Hofstadler
Rangarajan Sampath
Kristin Sannes Lowery
Christian Massire
Richard H Griffey
Original Assignee
Isis Pharmaceuticals Inc
Steven A Hofstadler
Rangarajan Sampath
Kristin Sannes Lowery
Christian Massire
Richard H Griffey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc, Steven A Hofstadler, Rangarajan Sampath, Kristin Sannes Lowery, Christian Massire, Richard H Griffey filed Critical Isis Pharmaceuticals Inc
Publication of WO2004110386A2 publication Critical patent/WO2004110386A2/en
Publication of WO2004110386A3 publication Critical patent/WO2004110386A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Polynucleotides comprising molecular interaction sites of coronavirus RNA that have particular secondary structure are provided. Methods of using such polynucleotides to screen, virtually or actually, combinatorial libraries of compounds that bind thereto are also provided. Methods of modulating the activity of coronavirus RNA by contacting coronavirus RNA with a compound identified by such virtual or actual screening are also provided.
PCT/US2004/019022 2003-06-12 2004-06-14 Molecular interaction sites of coronavirus rna and methods of modulating the same WO2004110386A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47782103P 2003-06-12 2003-06-12
US60/477,821 2003-06-12

Publications (2)

Publication Number Publication Date
WO2004110386A2 WO2004110386A2 (en) 2004-12-23
WO2004110386A3 true WO2004110386A3 (en) 2006-09-21

Family

ID=33551768

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/019022 WO2004110386A2 (en) 2003-06-12 2004-06-14 Molecular interaction sites of coronavirus rna and methods of modulating the same

Country Status (1)

Country Link
WO (1) WO2004110386A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101007469B1 (en) 2006-12-22 2011-01-12 성균관대학교산학협력단 Homopiperazine compound for inhibition of ribosomal frameshifting by binding to rna pseudoknot structure of sars coronavirus

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HEROLD ET AL.: "An 'elaborated' pseudoknot is required for high frequency frameshifting during translation of HCV 229E polymerase", NUCLEIC ACIDS RESEARCH, vol. 21, no. 25, 1993, pages 5838 - 5842 *
TOULME ET AL.: "Modulation of RNA Function by Oligonucleotides Recognizing RNA Structure", PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, vol. 69, 2001, pages 1 - 46 *

Also Published As

Publication number Publication date
WO2004110386A2 (en) 2004-12-23

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