WO2003014136A1 - Composes de 11a-azalide et methode de production de ces composes - Google Patents

Composes de 11a-azalide et methode de production de ces composes Download PDF

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Publication number
WO2003014136A1
WO2003014136A1 PCT/JP2002/008081 JP0208081W WO03014136A1 WO 2003014136 A1 WO2003014136 A1 WO 2003014136A1 JP 0208081 W JP0208081 W JP 0208081W WO 03014136 A1 WO03014136 A1 WO 03014136A1
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WO
WIPO (PCT)
Prior art keywords
represents hydrogen
hydrogen
alkyl
same
hydroxy
Prior art date
Application number
PCT/JP2002/008081
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English (en)
Japanese (ja)
Inventor
Toshifumi Asaka
Akira Manaka
Tetsuya Tanikawa
Tomohiro Sugimoto
Youichi Shimazaki
Masakazu Sato
Original Assignee
Taisho Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co., Ltd. filed Critical Taisho Pharmaceutical Co., Ltd.
Priority to JP2003519085A priority Critical patent/JP4311203B2/ja
Publication of WO2003014136A1 publication Critical patent/WO2003014136A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne des composés de 11a-azalide de la formule générale (1) ou des sels pharmaceutiquement acceptables desdits composés. Dans ladite formule, R1 est hydrogène, alkyle C¿1-10?, etc.; R?2¿ est hydrogène, hydroxy, etc.; R3 est hydrogène, acétyle, etc.; R4 et R5 sont chacun hydrogène, alkyle C¿1-10?, etc.; R?6¿ est hydrogène, hydroxy, etc.; R7 est hydrogène, ou R6 et R7 forment ensemble carbonyle, etc.; R8 est hydrogène, halogéno, etc.; X est carbonyle, etc.; Y est un groupe de la formule générale (14) (dans laquelle k est un entier compris entre 2 et 4; et R?24 et R25¿ sont identiques ou différents et représentent chacun hydrogène, alkyle C¿1-10?, etc.); et Z est oxygène, etc. Ces composés sont utiles comme nouveaux antibiotiques ayant une action antibactérienne non seulement sur les souches sensibles à l'érythromycine existantes, mais également sur les souches tolérants à l'érythromycine (par exemple, pneumococci et streptococci tolérants).
PCT/JP2002/008081 2001-08-08 2002-08-07 Composes de 11a-azalide et methode de production de ces composes WO2003014136A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2003519085A JP4311203B2 (ja) 2001-08-08 2002-08-07 １１ａ−アザライド化合物及びその製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-240263 2001-08-08
JP2001240263 2001-08-08

Publications (1)

Publication Number Publication Date
WO2003014136A1 true WO2003014136A1 (fr) 2003-02-20

Family

ID=19070904

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/008081 WO2003014136A1 (fr) 2001-08-08 2002-08-07 Composes de 11a-azalide et methode de production de ces composes

Country Status (2)

Country Link
JP (1) JP4311203B2 (fr)
WO (1) WO2003014136A1 (fr)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004108744A2 (fr) * 2003-05-19 2004-12-16 Prasad K Deshpande Azalides et azaketolides possedant une activite antimicrobienne
WO2005019238A1 (fr) * 2003-08-22 2005-03-03 Meiji Seika Kaisha, Ltd. Nouveaux derives d'azalide et d'azalactam et procede permettant de produire ces derives
US7015203B2 (en) 1998-01-02 2006-03-21 Pfizer Inc. Macrolides
JP2006528667A (ja) * 2003-05-13 2006-12-21 グラクソ　グループ　リミテッド 新規１４−及び１５−員環化合物
JP2006528947A (ja) * 2003-05-13 2006-12-28 グラクソ　グループ　リミテッド ４”−置換マクロライド
JP2007500193A (ja) * 2003-05-13 2007-01-11 グラクソ　グループ　リミテッド 新規な１４−及び１５−員環化合物
JP2007502313A (ja) * 2003-05-13 2007-02-08 グラクソ　グループ　リミテッド 新規１４及び１５員環化合物
EP1985620A1 (fr) * 2006-02-07 2008-10-29 Taisho Pharmaceutical Co., Ltd COMPOSÉ 10a-AZALIDE
WO2009019868A1 (fr) 2007-08-06 2009-02-12 Taisho Pharmaceutical Co., Ltd. Composé 10a-azalide réticulé en position 10a et en position 12
WO2009139181A1 (fr) 2008-05-15 2009-11-19 大正製薬株式会社 Composé 10a-azalide ayant une structure de cycle à 4 chaînons
WO2017194452A1 (fr) * 2016-05-11 2017-11-16 Fidelta D.O.O. Composés macrolides de type seco
JP2022507776A (ja) * 2018-11-19 2022-01-18 ジカニ セラピューティクス， インコーポレイテッド Ｃ１０－アルキレン置換された１３員マクロライド及びそれらの使用
JP2022507795A (ja) * 2018-11-19 2022-01-18 ジカニ セラピューティクス， インコーポレイテッド Ｃ１０環状置換１３員マクロライド及びそれらの使用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06247996A (ja) * 1993-02-25 1994-09-06 Taisho Pharmaceut Co Ltd ６−ｏ−メチルエリスロマイシンａ誘導体
EP0895999A1 (fr) * 1997-08-06 1999-02-10 Pfizer Products Inc. Macrolides antibiotiques substitués C"-4
WO2000031097A1 (fr) * 1998-11-20 2000-06-02 Pfizer Products Inc. Azalides a 13 elements et leur utilisation en tant qu'antibiotiques

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06247996A (ja) * 1993-02-25 1994-09-06 Taisho Pharmaceut Co Ltd ６−ｏ−メチルエリスロマイシンａ誘導体
EP0895999A1 (fr) * 1997-08-06 1999-02-10 Pfizer Products Inc. Macrolides antibiotiques substitués C"-4
WO2000031097A1 (fr) * 1998-11-20 2000-06-02 Pfizer Products Inc. Azalides a 13 elements et leur utilisation en tant qu'antibiotiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WADDELL SHERMAN T. ET AL.: "Chimeric azalides with simplified western portions", TETRAHEDRON LETTERS, vol. 34, no. 34, 20 August 1993 (1993-08-20), pages 5385 - 5388, XP002959892 *

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7015203B2 (en) 1998-01-02 2006-03-21 Pfizer Inc. Macrolides
JP2006528667A (ja) * 2003-05-13 2006-12-21 グラクソ　グループ　リミテッド 新規１４−及び１５−員環化合物
JP2006528947A (ja) * 2003-05-13 2006-12-28 グラクソ　グループ　リミテッド ４”−置換マクロライド
JP2007500193A (ja) * 2003-05-13 2007-01-11 グラクソ　グループ　リミテッド 新規な１４−及び１５−員環化合物
JP2007502313A (ja) * 2003-05-13 2007-02-08 グラクソ　グループ　リミテッド 新規１４及び１５員環化合物
WO2004108744A2 (fr) * 2003-05-19 2004-12-16 Prasad K Deshpande Azalides et azaketolides possedant une activite antimicrobienne
WO2004108744A3 (fr) * 2003-05-19 2005-03-24 Prasad K Deshpande Azalides et azaketolides possedant une activite antimicrobienne
WO2005019238A1 (fr) * 2003-08-22 2005-03-03 Meiji Seika Kaisha, Ltd. Nouveaux derives d'azalide et d'azalactam et procede permettant de produire ces derives
US7365174B2 (en) 2003-08-22 2008-04-29 Meiji Seika Kaisha, Ltd. Azalide and azalactam derivatives and method for producing the same
US8097708B2 (en) 2006-02-07 2012-01-17 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound
EP1985620A1 (fr) * 2006-02-07 2008-10-29 Taisho Pharmaceutical Co., Ltd COMPOSÉ 10a-AZALIDE
EP1985620A4 (fr) * 2006-02-07 2012-08-15 Taisho Pharmaceutical Co Ltd COMPOSÉ 10a-AZALIDE
JP5015016B2 (ja) * 2006-02-07 2012-08-29 大正製薬株式会社 １０ａ−アザライド化合物
US8293715B2 (en) 2007-08-06 2012-10-23 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound crosslinked at 10a- and 12-positions
WO2009019868A1 (fr) 2007-08-06 2009-02-12 Taisho Pharmaceutical Co., Ltd. Composé 10a-azalide réticulé en position 10a et en position 12
US8299035B2 (en) 2008-05-15 2012-10-30 Taisho Pharmaceutucal Co., Ltd. 10a-azalide compound having 4-membered ring structure
WO2009139181A1 (fr) 2008-05-15 2009-11-19 大正製薬株式会社 Composé 10a-azalide ayant une structure de cycle à 4 chaînons
WO2017194452A1 (fr) * 2016-05-11 2017-11-16 Fidelta D.O.O. Composés macrolides de type seco
CN109311929A (zh) * 2016-05-11 2019-02-05 菲德尔塔公司 Seco大环内酯化合物
US10919910B2 (en) 2016-05-11 2021-02-16 Fidelta D.O.O. Seco macrolide compounds
CN109311929B (zh) * 2016-05-11 2022-10-04 塞尔维塔公司 Seco大环内酯化合物
US11512096B2 (en) 2016-05-11 2022-11-29 Selvita D.O.O. Seco macrolide compounds
JP2022507776A (ja) * 2018-11-19 2022-01-18 ジカニ セラピューティクス， インコーポレイテッド Ｃ１０－アルキレン置換された１３員マクロライド及びそれらの使用
JP2022507795A (ja) * 2018-11-19 2022-01-18 ジカニ セラピューティクス， インコーポレイテッド Ｃ１０環状置換１３員マクロライド及びそれらの使用
JP7551610B2 (ja) 2018-11-19 2024-09-17 ジカニ セラピューティクス， インコーポレイテッド Ｃ１０－アルキレン置換された１３員マクロライド及びそれらの使用

Also Published As

Publication number Publication date
JP4311203B2 (ja) 2009-08-12
JPWO2003014136A1 (ja) 2004-11-25

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