WO2003003057A3 - System and method for capturing multi-color fish images - Google Patents

System and method for capturing multi-color fish images Download PDF

Info

Publication number
WO2003003057A3
WO2003003057A3 PCT/IL2002/000450 IL0200450W WO03003057A3 WO 2003003057 A3 WO2003003057 A3 WO 2003003057A3 IL 0200450 W IL0200450 W IL 0200450W WO 03003057 A3 WO03003057 A3 WO 03003057A3
Authority
WO
WIPO (PCT)
Prior art keywords
biological sample
image
color
dark
capturing
Prior art date
Application number
PCT/IL2002/000450
Other languages
French (fr)
Other versions
WO2003003057A2 (en
Inventor
Opher Shapira
Yuval Harari
Eran Kaplan
Original Assignee
Bioview Ltd
Opher Shapira
Yuval Harari
Eran Kaplan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioview Ltd, Opher Shapira, Yuval Harari, Eran Kaplan filed Critical Bioview Ltd
Priority to AU2002309241A priority Critical patent/AU2002309241A1/en
Publication of WO2003003057A2 publication Critical patent/WO2003003057A2/en
Publication of WO2003003057A3 publication Critical patent/WO2003003057A3/en

Links

Classifications

    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N25/00—Circuitry of solid-state image sensors [SSIS]; Control thereof
    • H04N25/60—Noise processing, e.g. detecting, correcting, reducing or removing noise
    • H04N25/63—Noise processing, e.g. detecting, correcting, reducing or removing noise applied to dark current
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N25/00—Circuitry of solid-state image sensors [SSIS]; Control thereof
    • H04N25/60—Noise processing, e.g. detecting, correcting, reducing or removing noise
    • H04N25/67—Noise processing, e.g. detecting, correcting, reducing or removing noise applied to fixed-pattern noise, e.g. non-uniformity of response
    • H04N25/671—Noise processing, e.g. detecting, correcting, reducing or removing noise applied to fixed-pattern noise, e.g. non-uniformity of response for non-uniformity detection or correction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2543/00—Reactions characterised by the reaction site, e.g. cell or chromosome
    • C12Q2543/10—Reactions characterised by the reaction site, e.g. cell or chromosome the purpose being "in situ" analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/619—Detection means characterised by use of a special device being a video camera

Landscapes

  • Engineering & Computer Science (AREA)
  • Multimedia (AREA)
  • Signal Processing (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Image Processing (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A method of obtaining multi-color FISH images is provided. The method is effected by: (a) using a color imager for capturing a dark image of a magnified biological sample stained with as least two distinct FISH probes; (b) determining dark intensity (Id) for each pixel of the dark image; (c) using the color imager for capturing a fluorescently illuminated image of the magnified biological sample; and (d) correcting an intensity (I) of each pixel of the fluorescently illuminated image of the biological sample according to its dark intensity (Id) to thereby obtain a multi-color FISH image of the biological sample.
PCT/IL2002/000450 2001-06-27 2002-06-11 System and method for capturing multi-color fish images WO2003003057A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002309241A AU2002309241A1 (en) 2001-06-27 2002-06-11 System and method for capturing multi-color fish images

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89160301A 2001-06-27 2001-06-27
US09/891,603 2001-06-27

Publications (2)

Publication Number Publication Date
WO2003003057A2 WO2003003057A2 (en) 2003-01-09
WO2003003057A3 true WO2003003057A3 (en) 2003-11-27

Family

ID=25398508

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2002/000450 WO2003003057A2 (en) 2001-06-27 2002-06-11 System and method for capturing multi-color fish images

Country Status (2)

Country Link
AU (1) AU2002309241A1 (en)
WO (1) WO2003003057A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9017942B2 (en) 2006-06-14 2015-04-28 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US20080070792A1 (en) 2006-06-14 2008-03-20 Roland Stoughton Use of highly parallel snp genotyping for fetal diagnosis
US7787112B2 (en) * 2007-10-22 2010-08-31 Visiongate, Inc. Depth of field extension for optical tomography
WO2011143508A2 (en) * 2010-05-12 2011-11-17 Li-Cor, Inc. Wide dynamic range imaging

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5414465A (en) * 1993-01-14 1995-05-09 Sony Corporation Luminance signal generator with interpolation
US5579156A (en) * 1994-05-18 1996-11-26 Carl-Zeiss-Stiftung Photomicroscope with a video camera and an exposure time control for a still camera
US6144408A (en) * 1995-02-24 2000-11-07 Eastman Kodak Company Black pattern correction for charge transfer sensor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5414465A (en) * 1993-01-14 1995-05-09 Sony Corporation Luminance signal generator with interpolation
US5579156A (en) * 1994-05-18 1996-11-26 Carl-Zeiss-Stiftung Photomicroscope with a video camera and an exposure time control for a still camera
US6144408A (en) * 1995-02-24 2000-11-07 Eastman Kodak Company Black pattern correction for charge transfer sensor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BORNFLETH ET AL.: "Comparative genomic hybridization imaging by the one-chip true-color CCD camera kappa CF 15 MC", CYTOMETRY, vol. 24, 1996, pages 1 - 13, XP002968979 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9017942B2 (en) 2006-06-14 2015-04-28 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US9273355B2 (en) 2006-06-14 2016-03-01 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US9347100B2 (en) 2006-06-14 2016-05-24 Gpb Scientific, Llc Rare cell analysis using sample splitting and DNA tags

Also Published As

Publication number Publication date
WO2003003057A2 (en) 2003-01-09
AU2002309241A1 (en) 2003-03-03

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