WO2002097706A1 - Method and appratus for computer modeling a joint - Google Patents

Method and appratus for computer modeling a joint Download PDF

Info

Publication number
WO2002097706A1
WO2002097706A1 PCT/US2002/016770 US0216770W WO02097706A1 WO 2002097706 A1 WO2002097706 A1 WO 2002097706A1 US 0216770 W US0216770 W US 0216770W WO 02097706 A1 WO02097706 A1 WO 02097706A1
Authority
WO
WIPO (PCT)
Prior art keywords
biological
joint
state
processes
biological processes
Prior art date
Application number
PCT/US2002/016770
Other languages
English (en)
French (fr)
Inventor
Nadine A. Defranoux
Todd B. Dubnicoff
David J. Ii Klinke
Annette K. Lewis
Thomas S. Paterson
Saroja Ramanujan
Lisl K. M. Shoda
Karl Petter Soderstrom
Herbert K. Struemper
Original Assignee
Entelos, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Entelos, Inc. filed Critical Entelos, Inc.
Priority to EP02752004A priority Critical patent/EP1390901A4/en
Priority to CA002447920A priority patent/CA2447920A1/en
Priority to JP2003500813A priority patent/JP2005501315A/ja
Priority to IL15905702A priority patent/IL159057A0/xx
Publication of WO2002097706A1 publication Critical patent/WO2002097706A1/en
Priority to IL159057A priority patent/IL159057A/en

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30673—Lubricating means, e.g. synovial pocket
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30943—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using mathematical models
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30952—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using CAD-CAM techniques or NC-techniques
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
PCT/US2002/016770 2001-05-29 2002-05-28 Method and appratus for computer modeling a joint WO2002097706A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP02752004A EP1390901A4 (en) 2001-05-29 2002-05-28 METHOD AND DEVICE FOR COMPUTER MODELING A JOINT
CA002447920A CA2447920A1 (en) 2001-05-29 2002-05-28 Method and appratus for computer modeling a joint
JP2003500813A JP2005501315A (ja) 2001-05-29 2002-05-28 コンピュータで関節のモデルを作るための方法と装置
IL15905702A IL159057A0 (en) 2001-05-29 2002-05-28 Method and apparatus for computer modeling a joint
IL159057A IL159057A (en) 2001-05-29 2003-11-25 Method and apparatus for computer modeling a joint

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29353301P 2001-05-29 2001-05-29
US60/293,533 2001-05-29
US10/154,123 US6862561B2 (en) 2001-05-29 2002-05-22 Method and apparatus for computer modeling a joint
US10/154,123 2002-05-23

Publications (1)

Publication Number Publication Date
WO2002097706A1 true WO2002097706A1 (en) 2002-12-05

Family

ID=26851167

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/016770 WO2002097706A1 (en) 2001-05-29 2002-05-28 Method and appratus for computer modeling a joint

Country Status (6)

Country Link
US (2) US6862561B2 (US20060058988A1-20060316-C00002.png)
EP (1) EP1390901A4 (US20060058988A1-20060316-C00002.png)
JP (1) JP2005501315A (US20060058988A1-20060316-C00002.png)
CA (1) CA2447920A1 (US20060058988A1-20060316-C00002.png)
IL (2) IL159057A0 (US20060058988A1-20060316-C00002.png)
WO (1) WO2002097706A1 (US20060058988A1-20060316-C00002.png)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1664763A2 (en) * 2003-09-11 2006-06-07 Entelos, Inc. Apparatus and method for identifying therapeutic targets using a computer model
US7069534B2 (en) 2003-12-17 2006-06-27 Sahouria Emile Y Mask creation with hierarchy management using cover cells
US7654955B2 (en) 2003-11-19 2010-02-02 Entelos, Inc. Apparatus and methods for assessing metabolic substrate utilization
US7844431B2 (en) 2004-02-20 2010-11-30 The Mathworks, Inc. Method and apparatus for integrated modeling, simulation and analysis of chemical and biochemical reactions
US8554486B2 (en) 2004-02-20 2013-10-08 The Mathworks, Inc. Method, computer program product, and apparatus for selective memory restoration of a simulation

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8944070B2 (en) 1999-04-07 2015-02-03 Intuitive Surgical Operations, Inc. Non-force reflecting method for providing tool force information to a user of a telesurgical system
US7136787B2 (en) 2001-12-19 2006-11-14 Archimedes, Inc. Generation of continuous mathematical model for common features of a subject group
US20050125158A1 (en) * 2001-12-19 2005-06-09 Kaiser Foundation Health Plan Inc. Generating a mathematical model for diabetes
GB2399187B (en) * 2002-07-24 2005-06-15 Rolls Royce Plc Method of generating a multifidelity model of a system
US20050118171A1 (en) * 2003-09-11 2005-06-02 Entelos, Inc. Treatment of rheumatoid arthritis with CD99 antagonists
AU2004280966A1 (en) * 2003-10-07 2005-04-21 Entelos, Inc. Simulating patient-specific outcomes
WO2005042002A2 (en) * 2003-10-30 2005-05-12 Entelos, Inc. Treatment of rhematoid arthritis with flip antagonists
US20050148496A1 (en) * 2003-11-26 2005-07-07 Entelos, Inc. Treatment of rheumatoid arthritis with hypoxia inducible factor-1alpha antagonists
WO2005058351A2 (en) * 2003-12-17 2005-06-30 Entelos, Inc. Treatment of rheumatoid arthritis with soluble fas-ligand cross-linkers
US20050158321A1 (en) * 2003-12-17 2005-07-21 Entelos, Inc. Treatment of rheumatoid arthritis with galectin-3 antagonists
US7827181B2 (en) * 2004-09-30 2010-11-02 Microsoft Corporation Click distance determination
WO2006084196A2 (en) * 2005-02-04 2006-08-10 Entelos, Inc. Method for defining virtual patient populations
WO2006099544A2 (en) * 2005-03-15 2006-09-21 Entelos, Inc. Apparatus and method for computer modeling type 1 diabetes
US9789608B2 (en) 2006-06-29 2017-10-17 Intuitive Surgical Operations, Inc. Synthetic representation of a surgical robot
US11259870B2 (en) 2005-06-06 2022-03-01 Intuitive Surgical Operations, Inc. Interactive user interfaces for minimally invasive telesurgical systems
EP2289454B1 (en) 2005-06-06 2020-03-25 Intuitive Surgical Operations, Inc. Laparoscopic ultrasound robotic surgical system
US8398541B2 (en) 2006-06-06 2013-03-19 Intuitive Surgical Operations, Inc. Interactive user interfaces for robotic minimally invasive surgical systems
EP3162318B1 (en) 2005-10-20 2019-10-16 Intuitive Surgical Operations, Inc. Auxiliary image display and manipulation on a computer display in a medical robotic system
EP1955190B1 (en) * 2005-11-10 2018-08-29 In Silico Biosciences, Inc. Method and apparatus for computer modeling the human brain for predicting drug effects
KR100697975B1 (ko) 2005-12-07 2007-03-23 한국전자통신연구원 인간형 다관절체의 애니메이션 생성 장치 및 그 방법
JP2009529166A (ja) * 2006-03-03 2009-08-13 エンテロス・インコーポレーテッド 呼吸器疾患のコンピュータモデリングのための装置および方法
AU2007231209B2 (en) * 2006-03-24 2011-02-03 Bae Systems Plc Method and system of decision making for distributed information distribution networks
CN104688281B (zh) 2006-06-13 2017-04-19 直观外科手术操作公司 微创手术系统
US10258425B2 (en) 2008-06-27 2019-04-16 Intuitive Surgical Operations, Inc. Medical robotic system providing an auxiliary view of articulatable instruments extending out of a distal end of an entry guide
US10008017B2 (en) 2006-06-29 2018-06-26 Intuitive Surgical Operations, Inc. Rendering tool information as graphic overlays on displayed images of tools
US20090192523A1 (en) 2006-06-29 2009-07-30 Intuitive Surgical, Inc. Synthetic representation of a surgical instrument
US9718190B2 (en) 2006-06-29 2017-08-01 Intuitive Surgical Operations, Inc. Tool position and identification indicator displayed in a boundary area of a computer display screen
WO2008051660A2 (en) * 2006-09-12 2008-05-02 Entelos, Inc. Apparatus and method for computer modeling chemical sensitivity of skin
EP2129317B1 (en) 2007-03-06 2014-11-05 The Cleveland Clinic Foundation Method for preparing for a surgical procedure
WO2008154515A1 (en) * 2007-06-08 2008-12-18 Entelos, Inc. Method and apparatus for modeling rheumatoid arthritis
US9138129B2 (en) 2007-06-13 2015-09-22 Intuitive Surgical Operations, Inc. Method and system for moving a plurality of articulated instruments in tandem back towards an entry guide
US8620473B2 (en) 2007-06-13 2013-12-31 Intuitive Surgical Operations, Inc. Medical robotic system with coupled control modes
US9469034B2 (en) 2007-06-13 2016-10-18 Intuitive Surgical Operations, Inc. Method and system for switching modes of a robotic system
US9089256B2 (en) 2008-06-27 2015-07-28 Intuitive Surgical Operations, Inc. Medical robotic system providing an auxiliary view including range of motion limitations for articulatable instruments extending out of a distal end of an entry guide
US9084623B2 (en) 2009-08-15 2015-07-21 Intuitive Surgical Operations, Inc. Controller assisted reconfiguration of an articulated instrument during movement into and out of an entry guide
WO2009064817A1 (en) * 2007-11-13 2009-05-22 Entelos, Inc. Simulating patient-specific outcomes
US8864652B2 (en) 2008-06-27 2014-10-21 Intuitive Surgical Operations, Inc. Medical robotic system providing computer generated auxiliary views of a camera instrument for controlling the positioning and orienting of its tip
US8660823B2 (en) * 2009-04-26 2014-02-25 Lester F. Ludwig Nonlinear and lie algebra structural analysis system for enzyme cascades, metabolic signal transduction, signaling pathways, catalytic chemical reaction networks, and immunology
US8918211B2 (en) 2010-02-12 2014-12-23 Intuitive Surgical Operations, Inc. Medical robotic system providing sensory feedback indicating a difference between a commanded state and a preferred pose of an articulated instrument
US9492927B2 (en) 2009-08-15 2016-11-15 Intuitive Surgical Operations, Inc. Application of force feedback on an input device to urge its operator to command an articulated instrument to a preferred pose
JP6014799B2 (ja) * 2010-07-20 2016-10-26 Ｌｉｎｆｏｐｓ有限会社 解析によるミクロな腫瘍免疫挙動の顕微鏡的把握方法
US10507066B2 (en) 2013-02-15 2019-12-17 Intuitive Surgical Operations, Inc. Providing information of tools by filtering image areas adjacent to or on displayed images of the tools
GB2544531A (en) * 2015-11-20 2017-05-24 Imorphics Ltd Image processing method
US20210100618A1 (en) * 2019-10-02 2021-04-08 Encore Medical, Lp Dba Djo Surgical Systems and methods for reconstruction and characterization of physiologically healthy and physiologically defective anatomical structures to facilitate pre-operative surgical planning
CN112618111B (zh) * 2020-12-14 2021-09-21 徐州医科大学 基于叶脉骨架结构的股骨柄假体设计方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6144954A (en) * 1998-01-27 2000-11-07 Li; Chou H. Automatic development of computer software

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN87208158U (zh) * 1987-05-20 1988-10-19 张雪珊 家用双功能灯
US5494668A (en) * 1994-07-11 1996-02-27 Patwardhan; Bhushan Method of treating musculoskeletal disease and a novel composition therefor
US5657255C1 (en) * 1995-04-14 2002-06-11 Interleukin Genetics Inc Hierarchic biological modelling system and method
US6108635A (en) * 1996-05-22 2000-08-22 Interleukin Genetics, Inc. Integrated disease information system
US5947899A (en) * 1996-08-23 1999-09-07 Physiome Sciences Computational system and method for modeling the heart
US6539347B1 (en) * 1997-10-31 2003-03-25 Entelos, Inc. Method of generating a display for a dynamic simulation model utilizing node and link representations
US6051029A (en) 1997-10-31 2000-04-18 Entelos, Inc. Method of generating a display for a dynamic simulation model utilizing node and link representations
US6069629A (en) 1997-11-25 2000-05-30 Entelos, Inc. Method of providing access to object parameters within a simulation model
US6078739A (en) 1997-11-25 2000-06-20 Entelos, Inc. Method of managing objects and parameter values associated with the objects within a simulation model
CA2369425C (en) * 1999-04-05 2012-06-26 American Board Of Family Practice, Inc. Computer architecture and process of patient generation
EP1171841B1 (en) 1999-04-21 2003-04-16 Physiome Sciences, Inc. System and method for modelling genetic, biochemical, biophysical and anatomical information
JP2004501415A (ja) 2000-02-07 2004-01-15 フィジオム・サイエンスィズ・インコーポレーテッド 遺伝子、生化学、生物物理、及び解剖学的な情報のシステム及び方法：ｉｎｓｉｌｉｃｏ細胞
JP2004508073A (ja) 2000-06-22 2004-03-18 フィジオム・サイエンスィズ・インコーポレーテッド 臓器でのタンパク質発現をモデル化するためのコンピュータ計算システム
US20020091666A1 (en) * 2000-07-07 2002-07-11 Rice John Jeremy Method and system for modeling biological systems
WO2002044992A2 (en) 2000-11-28 2002-06-06 Physiome Sciences, Inc. System for modeling biological pathways
US20030018457A1 (en) * 2001-03-13 2003-01-23 Lett Gregory Scott Biological modeling utilizing image data
US20030009099A1 (en) * 2001-07-09 2003-01-09 Lett Gregory Scott System and method for modeling biological systems
US20030087285A1 (en) * 2001-08-30 2003-05-08 Chow Carson C. Algorithm for estimating the outcome of inflammation following injury or infection

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6144954A (en) * 1998-01-27 2000-11-07 Li; Chou H. Automatic development of computer software

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
LUTZENBERGER C. ET AL.: "A three-dimensional model the human locomotor apparatus for analysis of hemiplegic gait", PROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, vol. 5, 1998, pages 2407 - 2410, XP010320495 *
NIELSEN C. ET AL.: "A computational method for comparing the behavior and possible failure of posthetic implants", IEEE 17TH ANNUAL CONFERENCE, ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, vol. 2, 1995, pages 1251 - 1252, XP010214770 *
POPOVIC M. ET AL.: "Cloning biological synergies improves control of elbow neuroprostheses", IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE, vol. 20, no. 1, January 2001 (2001-01-01) - February 2001 (2001-02-01), pages 74 - 81, XP002955739 *
SCHEINER A. ET AL.: "The effect of joint stiffness on simulation of the complete gait cycle", PROCEEDINGS OF THE 16TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE, ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, ENGINEERING ADVANCES: NEW OPPERTUNITIES FOR BIOMEDICAL ENGINEERS, 1994, pages 386 - 387, XP010145239 *
See also references of EP1390901A4 *
STOKES C.L. ET AL.: "Asthma physiolab: a dynamic, computer-based mathematical model of acute and chronic asthma", PROCEEDINGS OF THE FIRST JOINT BMES/EMBS CONFERENCE SERVING HUMANITY, ADVANCING TECHNOLOGY, 13 October 1999 (1999-10-13) - 16 October 1999 (1999-10-16), pages 1208, XP002955737 *
YVAN P. ET AL.: "3D Radiographic reconstruction of thoracic facet joints", IEEE 17TH ANNUAL CONFERENCE, ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, vol. 1, 1995, pages 397 - 398, XP002955738 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1664763A2 (en) * 2003-09-11 2006-06-07 Entelos, Inc. Apparatus and method for identifying therapeutic targets using a computer model
EP1664763A4 (en) * 2003-09-11 2008-03-12 Entelos Inc DEVICE AND METHOD FOR IDENTIFYING THERAPEUTIC TARGETS USING A COMPUTER MODEL
US7654955B2 (en) 2003-11-19 2010-02-02 Entelos, Inc. Apparatus and methods for assessing metabolic substrate utilization
US7069534B2 (en) 2003-12-17 2006-06-27 Sahouria Emile Y Mask creation with hierarchy management using cover cells
US7844431B2 (en) 2004-02-20 2010-11-30 The Mathworks, Inc. Method and apparatus for integrated modeling, simulation and analysis of chemical and biochemical reactions
US8234098B2 (en) 2004-02-20 2012-07-31 The Mathworks, Inc. Method and apparatus for integrated modeling, simulation and analysis of chemical and biochemical reactions
US8554486B2 (en) 2004-02-20 2013-10-08 The Mathworks, Inc. Method, computer program product, and apparatus for selective memory restoration of a simulation

Also Published As

Publication number Publication date
JP2005501315A (ja) 2005-01-13
EP1390901A4 (en) 2011-03-02
US20060058988A1 (en) 2006-03-16
US6862561B2 (en) 2005-03-01
IL159057A (en) 2009-11-18
CA2447920A1 (en) 2002-12-05
IL159057A0 (en) 2004-05-12
EP1390901A1 (en) 2004-02-25
US20030078759A1 (en) 2003-04-24
US7472050B2 (en) 2008-12-30

Similar Documents

Publication Publication Date Title
US6862561B2 (en) Method and apparatus for computer modeling a joint
JP2005501315A6 (ja) コンピュータで関節のモデルを作るための方法と装置
US20030104475A1 (en) Method and apparatus for computer modeling of an adaptive immune response
US20180039726A1 (en) Computer based system for predicting treatment outcomes
Pivonka et al. Role of mathematical modeling in bone fracture healing
Ziraldo et al. Computational modeling of inflammation and wound healing
Ruffoni et al. Effect of temporal changes in bone turnover on the bone mineralization density distribution: a computer simulation study
US20090150134A1 (en) Simulating Patient-Specific Outcomes
US20080027695A1 (en) Apparatus and method for computer modeling respiratory disease
Della Corte et al. A review of recent developments in mathematical modeling of bone remodeling
Versypt Multiscale modeling in disease
Heinig et al. The changing landscape for clinical research [published erratum appears in Acad Med 1999 Sep; 74 (9): 950]
Kaul Respiratory healthcare by design: computational approaches bringing respiratory precision and personalised medicine closer to bedside
Marques et al. Mechanostat parameters estimated from time-lapsed in vivo micro-computed tomography data of mechanically driven bone adaptation are logarithmically dependent on loading frequency
Altay et al. A novel clinical decision support system for liver fibrosis using evolutionary multi-objective method based numerical association analysis
Al‐Samkari et al. Extensive variability in platelet, bleeding, and QOL outcome measures in adult and pediatric ITP: Communication from the ISTH SSC subcommittee on platelet immunology
Ayati et al. Mathematics as a conduit for translational research in post‐traumatic osteoarthritis
Yankeelov et al. Designing clinical trials for patients who are not average
Rowberg Pharmaceutical research and development: a description and analysis of the process
KR102550465B1 (ko) 인공지능 기반의 가상 환자 관리 시스템
WO2008154515A1 (en) Method and apparatus for modeling rheumatoid arthritis
Li Biosimulation of vocal fold inflammation and wound healing
Robinson The association between patterns of glucocorticoid use and bone health
VIsser The potential of a novel cell-based therapy delivery implant in multiple sclerosis: an early health technology assessment
Sagalla et al. SUMMARY AND DISCUSSION

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2447920

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 159057

Country of ref document: IL

Ref document number: 2002752004

Country of ref document: EP

Ref document number: 2000/DELNP/2003

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2003500813

Country of ref document: JP

WWP Wipo information: published in national office

Ref document number: 2002752004

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642