WO2002092795A3 - Intrazelluläre bindung costimulatorischer moleküle - Google Patents

Intrazelluläre bindung costimulatorischer moleküle Download PDF

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Publication number
WO2002092795A3
WO2002092795A3 PCT/EP2002/005403 EP0205403W WO02092795A3 WO 2002092795 A3 WO2002092795 A3 WO 2002092795A3 EP 0205403 W EP0205403 W EP 0205403W WO 02092795 A3 WO02092795 A3 WO 02092795A3
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WO
WIPO (PCT)
Prior art keywords
antigen
costimulatory molecules
presenting cells
cells
intracellular
Prior art date
Application number
PCT/EP2002/005403
Other languages
English (en)
French (fr)
Other versions
WO2002092795A2 (de
Inventor
Ahmed Sheriff
Birgit Vogt
Original Assignee
Genethor Gmbh
Ahmed Sheriff
Birgit Vogt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genethor Gmbh, Ahmed Sheriff, Birgit Vogt filed Critical Genethor Gmbh
Publication of WO2002092795A2 publication Critical patent/WO2002092795A2/de
Publication of WO2002092795A3 publication Critical patent/WO2002092795A3/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4612—B-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464499—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • C12N5/064—Immunosuppressive dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Antigen-präsentierende Zelle oder deren Vorläuferzellen einschließlich Stammzellen, dadurch gekennzeichnet, dass in der antigen-präsentierenden Zelle B7-Rezeptor bindende Moleküle produziert werden, welche Rezeptoren der B7-Familie intrazellulär binden.Die Erfindung beruht auf einer Reduktion von spezifischen Immunreaktionen. Bei dem Verfahren werden Antigen-produzierende Zellen zur Unterdrückung von Abstoßungsreaktionen gegen Transplantate veranlasst.
PCT/EP2002/005403 2001-05-16 2002-05-16 Intrazelluläre bindung costimulatorischer moleküle WO2002092795A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10123765 2001-05-16
DE10123765.0 2001-05-16

Publications (2)

Publication Number Publication Date
WO2002092795A2 WO2002092795A2 (de) 2002-11-21
WO2002092795A3 true WO2002092795A3 (de) 2003-01-09

Family

ID=7684957

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/005403 WO2002092795A2 (de) 2001-05-16 2002-05-16 Intrazelluläre bindung costimulatorischer moleküle

Country Status (1)

Country Link
WO (1) WO2002092795A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005017163A2 (en) * 2003-08-15 2005-02-24 Imperial College Innovations Limited Phenotypic knockout of cell-surface proteins

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000066715A1 (de) * 1999-05-04 2000-11-09 Genethor Gmbh Verfahren zur reduzierung von spezifischen immunreaktionen
WO2002012453A1 (de) * 2000-08-09 2002-02-14 Genethor Gmbh Verfahren zur reduzierung von spezifischen immunreaktionen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000066715A1 (de) * 1999-05-04 2000-11-09 Genethor Gmbh Verfahren zur reduzierung von spezifischen immunreaktionen
WO2002012453A1 (de) * 2000-08-09 2002-02-14 Genethor Gmbh Verfahren zur reduzierung von spezifischen immunreaktionen

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MANDELBROT DIDIER A ET AL: "B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.", JOURNAL OF CLINICAL INVESTIGATION, vol. 107, no. 7, April 2001 (2001-04-01), pages 881 - 887, XP002218129, ISSN: 0021-9738 *
TSENG SU-YI ET AL: "B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 193, no. 7, 2 April 2001 (2001-04-02), pages 839 - 845, XP002189416, ISSN: 0022-1007 *

Also Published As

Publication number Publication date
WO2002092795A2 (de) 2002-11-21

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