WO2002090585A3 - Genetic polymorphism pattern of tgfb1 as marker for susceptability to renal disease - Google Patents

Genetic polymorphism pattern of tgfb1 as marker for susceptability to renal disease Download PDF

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Publication number
WO2002090585A3
WO2002090585A3 PCT/GB2002/002066 GB0202066W WO02090585A3 WO 2002090585 A3 WO2002090585 A3 WO 2002090585A3 GB 0202066 W GB0202066 W GB 0202066W WO 02090585 A3 WO02090585 A3 WO 02090585A3
Authority
WO
WIPO (PCT)
Prior art keywords
tgfb1
polymorphism pattern
renal disease
susceptability
marker
Prior art date
Application number
PCT/GB2002/002066
Other languages
French (fr)
Other versions
WO2002090585A2 (en
Inventor
Abdel Megiud El-Nahas
Alexandra Blakemore
Mahmoud Salah Khalil
Original Assignee
Univ Sheffield Hallam
Abdel Megiud El-Nahas
Alexandra Blakemore
Mahmoud Salah Khalil
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Sheffield Hallam, Abdel Megiud El-Nahas, Alexandra Blakemore, Mahmoud Salah Khalil filed Critical Univ Sheffield Hallam
Priority to AU2002307918A priority Critical patent/AU2002307918A1/en
Publication of WO2002090585A2 publication Critical patent/WO2002090585A2/en
Publication of WO2002090585A3 publication Critical patent/WO2002090585A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

Methods and kits are disclosed for detecting an individual's susceptibility to renal disease. Methods comprise obtaining a biological sample from an individual and determining the presence or absence of a genetic polymorphism pattern in TGFB1, which polymorphism pattern is associated with progression of renal failure.
PCT/GB2002/002066 2001-05-09 2002-05-08 Genetic polymorphism pattern of tgfb1 as marker for susceptability to renal disease WO2002090585A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002307918A AU2002307918A1 (en) 2001-05-09 2002-05-08 Genetic polymorphism pattern of tgfb1 as marker for susceptability to renal disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0111277.0 2001-05-09
GBGB0111277.0A GB0111277D0 (en) 2001-05-09 2001-05-09 Gentle marker

Publications (2)

Publication Number Publication Date
WO2002090585A2 WO2002090585A2 (en) 2002-11-14
WO2002090585A3 true WO2002090585A3 (en) 2003-04-03

Family

ID=9914260

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/002066 WO2002090585A2 (en) 2001-05-09 2002-05-08 Genetic polymorphism pattern of tgfb1 as marker for susceptability to renal disease

Country Status (3)

Country Link
AU (1) AU2002307918A1 (en)
GB (1) GB0111277D0 (en)
WO (1) WO2002090585A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2075343A1 (en) * 2007-12-21 2009-07-01 Gert Mayer A method of diagnosing a progressive disease
CN106480200A (en) * 2016-10-25 2017-03-08 北京亿昊基因技术有限公司 A kind of detection method with corneal dystrophy associated gene mutation site rapidly and efficiently
WO2021059001A1 (en) * 2019-09-25 2021-04-01 Ficmac Method for detecting specific polymorphisms in the xrcc4, xrcc1, xpa, errcc2, tgfb and nlrp3 genes, and associated diagnostic kit

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997028280A1 (en) * 1996-01-17 1997-08-07 David John Grainger Diagnostic method and apparatus
WO2000049169A1 (en) * 1999-02-19 2000-08-24 Dzgenes, L.L.C. Diagnostic polymorphisms
WO2001073130A1 (en) * 2000-03-24 2001-10-04 Dzgenes, Llc Diagnostic polymorphisms of tgf-beta1 promoter

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997028280A1 (en) * 1996-01-17 1997-08-07 David John Grainger Diagnostic method and apparatus
WO2000049169A1 (en) * 1999-02-19 2000-08-24 Dzgenes, L.L.C. Diagnostic polymorphisms
WO2001073130A1 (en) * 2000-03-24 2001-10-04 Dzgenes, Llc Diagnostic polymorphisms of tgf-beta1 promoter

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BAAN C ET AL: "Renal failure after clinical heart transplantation is associated with the TGF-beta1 codon 10 gene polymorphism", JOURNAL OF HEART AND LUNG TRANSPLANTATION, vol. 19, no. 9, September 2000 (2000-09-01), pages 866 - 72, XP001133745 *
CAMBIEN F ET AL: "POLYMORPHISMS OF THE TRANSFORMING GROWTH FACTOR-BETA1 GENE IN RELATION TO MYOCARDIAL INFARCTION AND BLOOD PRESSURE THE ETUDE CAS-TEMOIN DE L'INFARCTUS DU MYOCARDE (ECTIM) STUDY", HYPERTENSION, XX, XX, vol. 28, no. 5, November 1996 (1996-11-01), pages 881 - 887, XP002942823, ISSN: 0194-911X *
FREEDMAN B I ET AL: "GENETIC LINKAGE ANALYSIS OF GROWTH FACTOR LOCI AND END-STAGE RENAL DISEASE IN AFRICAN AMERICANS", KIDNEY INTERNATIONAL, NEW YORK, NY, US, vol. 51, 1997, pages 819 - 825, XP002929244, ISSN: 0085-2538 *
INIGO P ET AL: "Relation between TGF-beta1 gene polymorphism's (-800, -500, codon 10 and 25) and chronic allograft nephropathy in renal transplant recipients", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 10, September 1999 (1999-09-01), pages 759A, XP008012454 *
KITANI A ET AL: "Treatment of experimental colitis by intranasal administration of TGFbta-1 plasmid", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 192, no. 1, 3 July 2000 (2000-07-03), pages 41 - 52, XP002207644, ISSN: 0022-1007 *
LI B ET AL: "TGF-BETA1 DNA POLYMORPHISMS, PROTEIN LEVELS, AND BLOOD PRESSURE", HYPERTENSION, XX, XX, vol. 33, no. PART II, 1999, pages 271 - 275, XP002929243, ISSN: 0194-911X *
SUTHANTHIRAN M ET AL: "TRANSFORMING GROWTH FACTOR-BETA1 HYPEREXPRESSION IN AFRICAN-AMERICAN HYPERTENSIVES: A NOVEL MEDIATOR OF HYPERTENSION AND/OR TARGET ORGAN DAMAGE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 97, no. 7, 28 March 2000 (2000-03-28), pages 3479 - 3484, XP002943597, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
GB0111277D0 (en) 2001-06-27
AU2002307918A1 (en) 2002-11-18
WO2002090585A2 (en) 2002-11-14

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