WO2002090530A3 - Kinases and phosphatases - Google Patents

Kinases and phosphatases Download PDF

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Publication number
WO2002090530A3
WO2002090530A3 PCT/US2002/001369 US0201369W WO02090530A3 WO 2002090530 A3 WO2002090530 A3 WO 2002090530A3 US 0201369 W US0201369 W US 0201369W WO 02090530 A3 WO02090530 A3 WO 02090530A3
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WO
WIPO (PCT)
Prior art keywords
kpp
phosphatases
kinases
provides
polynucleotides
Prior art date
Application number
PCT/US2002/001369
Other languages
French (fr)
Other versions
WO2002090530A2 (en
Inventor
Ernestine A Lee
Narinder K Chawla
Mariah R Baughn
Craig H Ison
Rajagopal Gururajan
Chandra Arvizu
Monique G Yao
Jennifer L Jackson
Tom Y Tang
Henry Yue
Bao Tran
Li Ding
Dyung Aina M Lu
Preeti G Lal
Bridget A Warren
Original Assignee
Incyte Genomics Inc
Ernestine A Lee
Narinder K Chawla
Mariah R Baughn
Craig H Ison
Rajagopal Gururajan
Chandra Arvizu
Monique G Yao
Jennifer L Jackson
Tom Y Tang
Henry Yue
Bao Tran
Li Ding
Dyung Aina M Lu
Preeti G Lal
Bridget A Warren
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Ernestine A Lee, Narinder K Chawla, Mariah R Baughn, Craig H Ison, Rajagopal Gururajan, Chandra Arvizu, Monique G Yao, Jennifer L Jackson, Tom Y Tang, Henry Yue, Bao Tran, Li Ding, Dyung Aina M Lu, Preeti G Lal, Bridget A Warren filed Critical Incyte Genomics Inc
Priority to EP02756071A priority Critical patent/EP1387889A2/en
Priority to US10/466,759 priority patent/US20040081983A1/en
Priority to JP2002587592A priority patent/JP2004521637A/en
Priority to AU2002321985A priority patent/AU2002321985A1/en
Priority to CA002435142A priority patent/CA2435142A1/en
Publication of WO2002090530A2 publication Critical patent/WO2002090530A2/en
Publication of WO2002090530A3 publication Critical patent/WO2002090530A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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Abstract

The invention provides human kinases and phosphatases (KPP) and polynucleotides which identify and encode KPP. The invention also provides expression vector, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP.
PCT/US2002/001369 2001-01-18 2002-01-16 Kinases and phosphatases WO2002090530A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP02756071A EP1387889A2 (en) 2001-01-18 2002-01-16 Kinases and phosphatases
US10/466,759 US20040081983A1 (en) 2002-01-16 2002-01-16 Kinases and phosphatases
JP2002587592A JP2004521637A (en) 2001-01-18 2002-01-16 Kinase and phosphotase
AU2002321985A AU2002321985A1 (en) 2001-01-18 2002-01-16 Kinases and phosphatases
CA002435142A CA2435142A1 (en) 2001-01-18 2002-01-16 Kinases and phosphatases

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US26308301P 2001-01-18 2001-01-18
US60/263,083 2001-01-18
US27111701P 2001-02-23 2001-02-23
US27120501P 2001-02-23 2001-02-23
US60/271,205 2001-02-23
US60/271,117 2001-02-23
US27685901P 2001-03-16 2001-03-16
US60/276,859 2001-03-16
US27850401P 2001-03-23 2001-03-23
US27852201P 2001-03-23 2001-03-23
US60/278,522 2001-03-23
US60/278,504 2001-03-23
US28051001P 2001-03-29 2001-03-29
US28026601P 2001-03-29 2001-03-29
US60/280,266 2001-03-29
US60/280,510 2001-03-29

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WO2002090530A2 WO2002090530A2 (en) 2002-11-14
WO2002090530A3 true WO2002090530A3 (en) 2003-11-20

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Publication number Priority date Publication date Assignee Title
US6723547B2 (en) * 2001-04-02 2004-04-20 Applera Corporation Isolated human phosphatase proteins, nucleic acid molecules encoding human phosphatase proteins, and uses thereof
CN102266272B (en) * 2002-11-27 2012-12-26 Dmi生物科学公司 Personal care composition and products
CN113694202B (en) * 2020-06-29 2023-03-31 江苏省中医院 Application of ASS1 or BCKDK inhibitor in preparation of medicine for treating ulcerative colitis

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US5585233A (en) * 1993-03-23 1996-12-17 Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. PTP-S31: A novel protein tyrosine phosphatase
WO2001012819A2 (en) * 1999-08-13 2001-02-22 Sugen, Inc. Protein phosphatases and diagnosis and treatment of phosphatase-related disorders
WO2001064911A2 (en) * 2000-02-29 2001-09-07 Millennium Pharmaceuticals, Inc. 18232, a dual specificity phosphatase
WO2002057450A2 (en) * 2000-11-29 2002-07-25 Curagen Corporation Proteins and nucleic acids encoding same

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US5585233A (en) * 1993-03-23 1996-12-17 Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. PTP-S31: A novel protein tyrosine phosphatase
WO2001012819A2 (en) * 1999-08-13 2001-02-22 Sugen, Inc. Protein phosphatases and diagnosis and treatment of phosphatase-related disorders
WO2001064911A2 (en) * 2000-02-29 2001-09-07 Millennium Pharmaceuticals, Inc. 18232, a dual specificity phosphatase
WO2002057450A2 (en) * 2000-11-29 2002-07-25 Curagen Corporation Proteins and nucleic acids encoding same

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Title
DATABASE EMBL [online] 13 February 1997 (1997-02-13), "Sequence 21 from patent US5585233", XP002240066, Database accession no. I32039 *
DATABASE EMBL [online] 13 July 1998 (1998-07-13), "rattus norvegicus glomerular mesangial cell receptor protein-tyrosine phosphatase precursor (PTPRQ) mRNA, complete cds", XP002240064, Database accession no. AF063249 *
DATABASE EMBL [online] 9 March 2001 (2001-03-09), "Sequence 25 from patent wo0112819", XP002230437, Database accession no. AX086028 *
DATABASE EPOP [online] 6 March 2001 (2001-03-06), "Sequence 26 from Patent wo0112819", XP002230760, Database accession no. ax086029 *
DATABASE GENESEQ [online] 18 December 2001 (2001-12-18), "Human cDNA encoding dual specific phosphatase, 18232", XP002230435, Database accession no. AAS12700 *
DATABASE GENESEQ [online] 18 December 2001 (2001-12-18), "Human dual specificity phosphatase, 18323", XP002230436, Database accession no. AAU08646 *
DATABASE GENESEQ [online] 24 October 2001 (2001-10-24), "Human Nov2c protein", XP002240069, Database accession no. AAO18738 *
DATABASE GENESEQ [online] 24 October 2002 (2002-10-24), "Human Nov2c coding sequence", XP002240068, Database accession no. ABT06283 *
DATABASE GENESEQ [online] 7 February 1997 (1997-02-07), "Sequence 22 from patent US5585233", XP002240067, Database accession no. AAB44477 *
DATABASE SWALL [online] 1 November 1998 (1998-11-01), "Glomerular mesangial cell receptor protein-tyrosine phosphatase precursor", XP002240065, Database accession no. O88488 *
DATABASE SWALL [online] 15 June 2001 (2001-06-15), "Dual specificity protein phosphatase 14 (MAP kinase phosphatase 6)", XP002230438, Database accession no. O95147 *
KEYSE S M: "AN EMERGING FAMILY OF DUAL SPECIFICITY MAP KINASE PHOSPHATASES", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR CELL RESEARCH, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 1265, 1995, pages 152 - 160, XP000196716, ISSN: 0167-4889 *
LI L ET AL: "Form, function, and regulation of protein tyrosine phosphatases and their involvement in human diseases.", SEMINARS IN IMMUNOLOGY. UNITED STATES FEB 2000, vol. 12, no. 1, February 2000 (2000-02-01), pages 75 - 84, XP002240063, ISSN: 1044-5323 *
MARTI F ET AL: "Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD.: 1950) UNITED STATES 1 JAN 2001, vol. 166, no. 1, o95147, 1 January 2001 (2001-01-01), pages 197 - 206, XP002230434, ISSN: 0022-1767 *
WRIGHT M B ET AL: "Proliferating and migrating mesangial cells responding to injury express a novel receptor protein-tyrosine phosphatase in experimental mesangial proliferative glomerulonephritis", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 37, AF063249, 11 September 1998 (1998-09-11), pages 23929 - 23937, XP002229880, ISSN: 0021-9258 *

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EP1387889A2 (en) 2004-02-11

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