WO2002083310A3 - Systemes de mesure microfluidique et procedes associes - Google Patents

Systemes de mesure microfluidique et procedes associes Download PDF

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Publication number
WO2002083310A3
WO2002083310A3 PCT/US2001/031790 US0131790W WO02083310A3 WO 2002083310 A3 WO2002083310 A3 WO 2002083310A3 US 0131790 W US0131790 W US 0131790W WO 02083310 A3 WO02083310 A3 WO 02083310A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
microfluidic
metering
methods
metered
Prior art date
Application number
PCT/US2001/031790
Other languages
English (en)
Other versions
WO2002083310A8 (fr
WO2002083310A2 (fr
Inventor
Stephen D O'connor
Christoph D Karp
Marci Pezzuto
Eugene Dantsker
Original Assignee
Nanostream Inc
Stephen D O'connor
Christoph D Karp
Marci Pezzuto
Eugene Dantsker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2001/012244 external-priority patent/WO2001078893A2/fr
Application filed by Nanostream Inc, Stephen D O'connor, Christoph D Karp, Marci Pezzuto, Eugene Dantsker filed Critical Nanostream Inc
Priority to AU2002213115A priority Critical patent/AU2002213115A1/en
Publication of WO2002083310A2 publication Critical patent/WO2002083310A2/fr
Publication of WO2002083310A3 publication Critical patent/WO2002083310A3/fr
Publication of WO2002083310A8 publication Critical patent/WO2002083310A8/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Abstract

L'invention concerne des dispositifs microfluidiques permettant de mesurer un flux de fluide. L'invention concerne des dispositifs et des procédés de mesure « tronc-branche » de portions de fluide, dans lesquels un ou plusieurs canaux branches de volume défini sont mesurés à partir d'une masse de fluide. L'invention concerne également la mesure d'au moins une portion discrète par le biais de la sélection des conditions de fourniture d'un premier et d'un second fluide à un canal microfluidique. Le premier fluide peut être un fluide et le second fluide un gaz. Des segments de canal à zone réduite permettent d'aider à mesurer un ou plusieurs portions de fluide discrets. Dans un autre aspect, un volume microfluidique est mesuré en remplissant une chambre microfluidique de fluide, en fermant un canal d'entrée de manière étanche, puis en en extrayant ledit fluide.
PCT/US2001/031790 2001-04-13 2001-10-12 Systemes de mesure microfluidique et procedes associes WO2002083310A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002213115A AU2002213115A1 (en) 2001-04-13 2001-10-12 Microfluidic metering systems and methods

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
USPCT/US01/12244 2001-04-13
PCT/US2001/012244 WO2001078893A2 (fr) 2000-04-14 2001-04-13 Barrieres d'ecoulement des fluides dans un systeme microfluidique
US30352001P 2001-07-07 2001-07-07
US60/303,520 2001-07-07

Publications (3)

Publication Number Publication Date
WO2002083310A2 WO2002083310A2 (fr) 2002-10-24
WO2002083310A3 true WO2002083310A3 (fr) 2003-01-23
WO2002083310A8 WO2002083310A8 (fr) 2003-05-01

Family

ID=26680460

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/031790 WO2002083310A2 (fr) 2001-04-13 2001-10-12 Systemes de mesure microfluidique et procedes associes

Country Status (2)

Country Link
AU (1) AU2002213115A1 (fr)
WO (1) WO2002083310A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6919058B2 (en) 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
WO2003072255A1 (fr) * 2002-02-23 2003-09-04 Nanostream, Inc. Diviseurs micro-hydrauliques multiples
AU2003253944A1 (en) * 2002-07-26 2004-02-16 Applera Corporation Micro-channel design features that facilitate centripetal fluid transfer
US7041258B2 (en) 2002-07-26 2006-05-09 Applera Corporation Micro-channel design features that facilitate centripetal fluid transfer
WO2006005923A1 (fr) * 2004-07-08 2006-01-19 Norgren Limited Systeme de distribution de liquide
DE102005042601A1 (de) * 2005-04-09 2006-10-12 Boehringer Ingelheim Microparts Gmbh Vorrichtung und Verfahren zur Untersuchung einer Probenflüssigkeit
DE102005016508A1 (de) * 2005-04-09 2006-10-12 Boehringer Ingelheim Microparts Gmbh Vorrichtung und Verfahren zur Untersuchung einer Probenflüssigkeit
DE102005016509A1 (de) * 2005-04-09 2006-10-12 Boehringer Ingelheim Microparts Gmbh Vorrichtung und Verfahren zur Untersuchung einer Probenflüssigkeit
JP4837725B2 (ja) 2005-04-09 2011-12-14 ベーリンガー インゲルハイム マイクロパーツ ゲゼルシャフト ミット ベシュレンクテル ハフツング サンプル液の検査装置及び方法
JP4888394B2 (ja) * 2005-11-07 2012-02-29 コニカミノルタエムジー株式会社 マイクロリアクタおよびそれを用いた送液方法
DE102010061910B4 (de) * 2010-11-24 2016-04-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Mikrofluidvorrichtung und Verfahren zum Herstellen derselben
GB201216454D0 (en) * 2012-09-14 2012-10-31 Carclo Technical Plastics Ltd Sample metering device
AP2016009089A0 (en) * 2013-08-23 2016-03-31 Daktari Diagnostics Inc Microfluidic metering of fluids
CN109954522A (zh) * 2017-12-22 2019-07-02 郑州达诺生物技术有限公司 多液体通道侧向层析定量检测装置及制备方法

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3471262A (en) * 1965-12-03 1969-10-07 Ceskoslovenska Akademie Ved Method and means for exactly sectionalizing a flow of liquid in a capillary tubing
US3756459A (en) * 1971-01-12 1973-09-04 Damon Corp Method and apparatus for metering fluid utilizing pressure differentials
US4259291A (en) * 1979-07-13 1981-03-31 Technicon Instruments Corporation Metering device
EP0107631A2 (fr) * 1982-09-28 1984-05-02 Bifok Ab Micro-conduits intégrés, pour analyse à écoulement continu
US4676274A (en) * 1985-02-28 1987-06-30 Brown James F Capillary flow control
US5834314A (en) * 1994-11-07 1998-11-10 Abbott Laboratories Method and apparatus for metering a fluid
WO1999017093A1 (fr) * 1997-09-26 1999-04-08 The Regents Of The University Of Michigan Deplacement de microgouttelettes
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
WO1999042805A1 (fr) * 1998-02-18 1999-08-26 Orchid Biosciences, Inc. Dispositif de distribution de volumes definis
WO2000021666A1 (fr) * 1998-10-14 2000-04-20 Caliper Technologies Corp. Systemes et procedes de transfert externe de materiaux

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3471262A (en) * 1965-12-03 1969-10-07 Ceskoslovenska Akademie Ved Method and means for exactly sectionalizing a flow of liquid in a capillary tubing
US3756459A (en) * 1971-01-12 1973-09-04 Damon Corp Method and apparatus for metering fluid utilizing pressure differentials
US4259291A (en) * 1979-07-13 1981-03-31 Technicon Instruments Corporation Metering device
EP0107631A2 (fr) * 1982-09-28 1984-05-02 Bifok Ab Micro-conduits intégrés, pour analyse à écoulement continu
US4676274A (en) * 1985-02-28 1987-06-30 Brown James F Capillary flow control
US5834314A (en) * 1994-11-07 1998-11-10 Abbott Laboratories Method and apparatus for metering a fluid
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
WO1999017093A1 (fr) * 1997-09-26 1999-04-08 The Regents Of The University Of Michigan Deplacement de microgouttelettes
WO1999042805A1 (fr) * 1998-02-18 1999-08-26 Orchid Biosciences, Inc. Dispositif de distribution de volumes definis
WO2000021666A1 (fr) * 1998-10-14 2000-04-20 Caliper Technologies Corp. Systemes et procedes de transfert externe de materiaux

Also Published As

Publication number Publication date
WO2002083310A8 (fr) 2003-05-01
AU2002213115A1 (en) 2002-10-28
WO2002083310A2 (fr) 2002-10-24

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