WO2002081523A3 - Procede de preparation et de selection d'anticorps - Google Patents

Procede de preparation et de selection d'anticorps Download PDF

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Publication number
WO2002081523A3
WO2002081523A3 PCT/FR2002/001164 FR0201164W WO02081523A3 WO 2002081523 A3 WO2002081523 A3 WO 2002081523A3 FR 0201164 W FR0201164 W FR 0201164W WO 02081523 A3 WO02081523 A3 WO 02081523A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparing
interest
selecting antibodies
polypeptide
preparing antibodies
Prior art date
Application number
PCT/FR2002/001164
Other languages
English (en)
Other versions
WO2002081523A2 (fr
Inventor
Herve Bazin
Yannick Nizet
Original Assignee
Technopharm
Herve Bazin
Yannick Nizet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technopharm, Herve Bazin, Yannick Nizet filed Critical Technopharm
Priority to CA002443303A priority Critical patent/CA2443303A1/fr
Priority to JP2002579908A priority patent/JP2004535168A/ja
Priority to EP02759814A priority patent/EP1373320A2/fr
Publication of WO2002081523A2 publication Critical patent/WO2002081523A2/fr
Publication of WO2002081523A3 publication Critical patent/WO2002081523A3/fr
Priority to US10/674,130 priority patent/US20050042718A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention a pour objet un procédé de préparation d'anticorps comprenant les étapes suivantes : a) la transfection d'une lignée cellulaire par une construction d'acide nucléique comprenant une séquence nucléique d'intérêt codant pour un polypeptide d'intérêt à exprimer à la surface des cellules de ladite lignée, b) la préparation d'anticorps dirigés contre le polypeptide d'intérêt avec les cellules préparées à l'étape (a) ou de leurs membranes.
PCT/FR2002/001164 2001-04-03 2002-04-03 Procede de preparation et de selection d'anticorps WO2002081523A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002443303A CA2443303A1 (fr) 2001-04-03 2002-04-03 Procede de preparation et de selection d'anticorps
JP2002579908A JP2004535168A (ja) 2001-04-03 2002-04-03 抗体の調製および選択方法
EP02759814A EP1373320A2 (fr) 2001-04-03 2002-04-03 Procede de preparation et de selection d'anticorps
US10/674,130 US20050042718A1 (en) 2001-04-03 2003-09-29 Method for preparing and selecting antibodies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0104525A FR2822846B1 (fr) 2001-04-03 2001-04-03 Procede de preparation et de selection d'anticorps
FR01/04525 2001-04-03

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/674,130 Continuation US20050042718A1 (en) 2001-04-03 2003-09-29 Method for preparing and selecting antibodies

Publications (2)

Publication Number Publication Date
WO2002081523A2 WO2002081523A2 (fr) 2002-10-17
WO2002081523A3 true WO2002081523A3 (fr) 2003-04-03

Family

ID=8861894

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2002/001164 WO2002081523A2 (fr) 2001-04-03 2002-04-03 Procede de preparation et de selection d'anticorps

Country Status (7)

Country Link
US (1) US20050042718A1 (fr)
EP (1) EP1373320A2 (fr)
JP (1) JP2004535168A (fr)
CN (1) CN1511163A (fr)
CA (1) CA2443303A1 (fr)
FR (1) FR2822846B1 (fr)
WO (1) WO2002081523A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101374865A (zh) * 2005-12-16 2009-02-25 健泰科生物技术公司 抗ox40l抗体及其使用方法
CN102241773B (zh) * 2010-05-13 2014-05-14 四川大学 抗骨髓瘤细胞多克隆抗体及其制备方法
NZ737423A (en) 2015-06-01 2019-08-30 Medigene Immunotherapies Gmbh Method for generating antibodies against t cell receptor
CN107922950B (zh) 2015-06-01 2021-12-31 基因医疗免疫疗法有限责任公司 T细胞受体文库
EA201891459A1 (ru) 2015-12-23 2018-11-30 Медиджин Иммьюнотерапиз Гмбх Новое поколение антигенспецифических tcr
WO2024062019A1 (fr) 2022-09-21 2024-03-28 Synabs Anticorps anti-ccr8 et leurs utilisations
CN116048156B (zh) * 2023-01-10 2024-01-30 江苏三联生物工程股份有限公司 一种电化学发光检测装置双向控温系统

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0733373A2 (fr) * 1995-03-23 1996-09-25 Bristol-Myers Squibb Company Compositions et procédés pour augmenter l'immunogénicité des cellules tumorales par l'administration de cellules transformées pour l'expression de B7 et CD2 protéines
US5776775A (en) * 1989-02-21 1998-07-07 Dana-Farber Cancer Institute Anti-LAM 1-3 antibody and hybridoma

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776775A (en) * 1989-02-21 1998-07-07 Dana-Farber Cancer Institute Anti-LAM 1-3 antibody and hybridoma
EP0733373A2 (fr) * 1995-03-23 1996-09-25 Bristol-Myers Squibb Company Compositions et procédés pour augmenter l'immunogénicité des cellules tumorales par l'administration de cellules transformées pour l'expression de B7 et CD2 protéines

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BOER DE M ET AL: "GENERATION OF MONOCLONAL ANTIBODIES TO HUMAN LYMPHOCYTE CELL SURFACE ANTIGENS USING INSECT CELLS EXPRESSING RECOMBINANT PROTEINS", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 152, 31 July 1992 (1992-07-31), pages 15 - 23, XP001005278, ISSN: 0022-1759 *
BORREBAECK C A K ET AL: "Human monoclonal antibodies produced by primary in vitro immunization of peripheral blood lymphocytes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 85, no. 11, June 1988 (1988-06-01), pages 3995 - 3999, XP002176306, ISSN: 0027-8424 *
HADDAD D ET AL: "COMPARATIVE STUDY OF DNA-BASED IMMUNIZATION VECTORS: EFFECT OF SECRETION SIGNALS ON THE ANTIBODY RESPONSES IN MICE", FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, ELSEVIER SCIENCE B.V., AMSTERDAM, NL, vol. 18, no. 3, 1997, pages 193 - 202, XP001042389, ISSN: 0928-8244 *
RITS M ET AL: "RAT MONOCLONAL ANTIBODIES VI. PRODUCTION OF IGA SECRETING HYBRIDOMAS WITH SPECIFICITY FOR THE 2,4-DINITROPHENYL (DNP) HAPTEN", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 89, no. 1, 1 May 1986 (1986-05-01), pages 81 - 87, XP001074181, ISSN: 0022-1759 *

Also Published As

Publication number Publication date
WO2002081523A2 (fr) 2002-10-17
US20050042718A1 (en) 2005-02-24
CA2443303A1 (fr) 2002-10-17
EP1373320A2 (fr) 2004-01-02
FR2822846B1 (fr) 2004-01-23
CN1511163A (zh) 2004-07-07
JP2004535168A (ja) 2004-11-25
FR2822846A1 (fr) 2002-10-04

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