WO2002077642A1 - Procede de criblage de medicaments destines a la prevention/au traitement de la glomerulonephrite proliferative - Google Patents

Procede de criblage de medicaments destines a la prevention/au traitement de la glomerulonephrite proliferative Download PDF

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Publication number
WO2002077642A1
WO2002077642A1 PCT/JP2002/002828 JP0202828W WO02077642A1 WO 2002077642 A1 WO2002077642 A1 WO 2002077642A1 JP 0202828 W JP0202828 W JP 0202828W WO 02077642 A1 WO02077642 A1 WO 02077642A1
Authority
WO
WIPO (PCT)
Prior art keywords
edg
polypeptide
ligand
cells
cell
Prior art date
Application number
PCT/JP2002/002828
Other languages
English (en)
Japanese (ja)
Inventor
Kazuchika Takagaki
Susumu Katsuma
Gozoh Tsujimoto
Original Assignee
Nippon Shinyaku Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co., Ltd. filed Critical Nippon Shinyaku Co., Ltd.
Publication of WO2002077642A1 publication Critical patent/WO2002077642A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9

Abstract

L'invention concerne une méthode de criblage d'un composé efficace pour prévenir/traiter la glomérulonéphrite proliférative, en particulier, la glomérulonéphrite proliférative mésangiale caractérisée par le fait qu'elle dépend de l'effet d'inhibition de l'activation de Edg-5.
PCT/JP2002/002828 2001-03-26 2002-03-25 Procede de criblage de medicaments destines a la prevention/au traitement de la glomerulonephrite proliferative WO2002077642A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001088018 2001-03-26
JP2001-88018 2001-03-26
JP2001-270551 2001-09-06
JP2001270551A JP2005300158A (ja) 2001-03-26 2001-09-06 増殖性糸球体腎炎の予防・治療用薬物のスクリーニング方法

Publications (1)

Publication Number Publication Date
WO2002077642A1 true WO2002077642A1 (fr) 2002-10-03

Family

ID=26612064

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/002828 WO2002077642A1 (fr) 2001-03-26 2002-03-25 Procede de criblage de medicaments destines a la prevention/au traitement de la glomerulonephrite proliferative

Country Status (2)

Country Link
JP (1) JP2005300158A (fr)
WO (1) WO2002077642A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052391A1 (fr) * 2002-12-12 2004-06-24 Takeda Pharmaceutical Company Limited Nouvelle utilisation de recepteurs edg
WO2014139883A1 (fr) * 2013-03-14 2014-09-18 Galapagos Nv Cibles et composés moléculaires, et méthodes utilisées pour les identifier, dans le cadre du traitement de la fibrose

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2528799T3 (es) * 2008-11-22 2015-02-12 Astute Medical, Inc. Métodos para el pronóstico de insuficiencia renal aguda

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999035259A1 (fr) * 1997-12-30 1999-07-15 Nps Allelix Corp. Identification des recepteurs des lysolipides impliques dans la reponse inflammatoire
WO2000056135A2 (fr) * 1999-03-23 2000-09-28 The Regents Of The University Of California Recepteurs de polypeptides humains pour lysophospholipides et sphingolipides et acides nucleiques les codant

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999035259A1 (fr) * 1997-12-30 1999-07-15 Nps Allelix Corp. Identification des recepteurs des lysolipides impliques dans la reponse inflammatoire
WO2000056135A2 (fr) * 1999-03-23 2000-09-28 The Regents Of The University Of California Recepteurs de polypeptides humains pour lysophospholipides et sphingolipides et acides nucleiques les codant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
OKAMOTO, H. ET AL., MOLECULAR AND CELLULAR BIOLOGY, vol. 20, no. 24, December 2000 (2000-12-01), pages 9247 - 9261, XP002951031 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052391A1 (fr) * 2002-12-12 2004-06-24 Takeda Pharmaceutical Company Limited Nouvelle utilisation de recepteurs edg
WO2014139883A1 (fr) * 2013-03-14 2014-09-18 Galapagos Nv Cibles et composés moléculaires, et méthodes utilisées pour les identifier, dans le cadre du traitement de la fibrose
US10048250B2 (en) 2013-03-14 2018-08-14 Galapagos Nv Molecular targets and compounds, and methods to identify the same, useful in the treatment of fibrotic diseases

Also Published As

Publication number Publication date
JP2005300158A (ja) 2005-10-27

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