WO2002074948A3 - Tissu animal comportant des antigenes carbohydrates compatibles en vue d'une greffe humaine - Google Patents
Tissu animal comportant des antigenes carbohydrates compatibles en vue d'une greffe humaine Download PDFInfo
- Publication number
- WO2002074948A3 WO2002074948A3 PCT/CA2002/000378 CA0200378W WO02074948A3 WO 2002074948 A3 WO2002074948 A3 WO 2002074948A3 CA 0200378 W CA0200378 W CA 0200378W WO 02074948 A3 WO02074948 A3 WO 02074948A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tissue
- converted
- animal tissue
- carbohydrate antigens
- compatible
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 4
- 108091007433 antigens Proteins 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 241001465754 Metazoa Species 0.000 title abstract 2
- 150000001720 carbohydrates Chemical class 0.000 title abstract 2
- 238000002054 transplantation Methods 0.000 title abstract 2
- 102100035833 Histo-blood group ABO system transferase Human genes 0.000 abstract 3
- KFEUJDWYNGMDBV-UHFFFAOYSA-N (N-Acetyl)-glucosamin-4-beta-galaktosid Natural products OC1C(NC(=O)C)C(O)OC(CO)C1OC1C(O)C(O)C(O)C(CO)O1 KFEUJDWYNGMDBV-UHFFFAOYSA-N 0.000 abstract 2
- 101710142776 Histo-blood group ABO system transferase Proteins 0.000 abstract 2
- KFEUJDWYNGMDBV-LODBTCKLSA-N N-acetyllactosamine Chemical compound O[C@@H]1[C@@H](NC(=O)C)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KFEUJDWYNGMDBV-LODBTCKLSA-N 0.000 abstract 2
- HESSGHHCXGBPAJ-UHFFFAOYSA-N N-acetyllactosamine Natural products CC(=O)NC(C=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O HESSGHHCXGBPAJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 102100040837 Galactoside alpha-(1,2)-fucosyltransferase 2 Human genes 0.000 abstract 1
- 102000030902 Galactosyltransferase Human genes 0.000 abstract 1
- 108060003306 Galactosyltransferase Proteins 0.000 abstract 1
- 101000893710 Homo sapiens Galactoside alpha-(1,2)-fucosyltransferase 2 Proteins 0.000 abstract 1
- 108700019146 Transgenes Proteins 0.000 abstract 1
- QIGJYVCQYDKYDW-SDOYDPJRSA-N alpha-D-galactosyl-(1->3)-D-galactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@H]1[C@@H](O)[C@@H](CO)OC(O)[C@@H]1O QIGJYVCQYDKYDW-SDOYDPJRSA-N 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
- A01K2267/025—Animal producing cells or organs for transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/04—Cells produced using nuclear transfer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002242538A AU2002242538B2 (en) | 2001-03-21 | 2002-03-21 | Animal tissue with carbohydrate antigens compatible for human transplantation |
EP02708083A EP1373498A2 (fr) | 2001-03-21 | 2002-03-21 | Tissu animal comportant des antigenes carbohydrates compatibles en vue d'une greffe humaine |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27781101P | 2001-03-21 | 2001-03-21 | |
US60/277,811 | 2001-03-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002074948A2 WO2002074948A2 (fr) | 2002-09-26 |
WO2002074948A3 true WO2002074948A3 (fr) | 2002-11-14 |
Family
ID=23062451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA2002/000378 WO2002074948A2 (fr) | 2001-03-21 | 2002-03-21 | Tissu animal comportant des antigenes carbohydrates compatibles en vue d'une greffe humaine |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1373498A2 (fr) |
AU (1) | AU2002242538B2 (fr) |
WO (1) | WO2002074948A2 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7033831B2 (en) | 2001-12-07 | 2006-04-25 | Geron Corporation | Islet cells from human embryonic stem cells |
PT2163614T (pt) * | 2002-08-21 | 2017-01-17 | Revivicor Inc | Animais porcinos que carecem de qualquer expressão de alfa 1,3 galactosiltransferase funcional |
WO2005009134A1 (fr) | 2003-07-21 | 2005-02-03 | Lifecell Corporation | Matrices de tissus acellulaires realisees a partir de tissus deficitaires en galactose $g(a)-1,3-galactose- |
US8415153B2 (en) | 2006-06-19 | 2013-04-09 | Geron Corporation | Differentiation and enrichment of islet-like cells from human pluripotent stem cells |
EP3799893A1 (fr) | 2013-11-04 | 2021-04-07 | LifeCell Corporation | Procédé d'élimination d'alpha-galactose |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995028412A1 (fr) * | 1994-04-13 | 1995-10-26 | Biotransplant, Inc. | PORC NEGATIF POUR L'α(1,3) GALACTOSYLTRANFERASE |
WO1995034202A1 (fr) * | 1994-06-15 | 1995-12-21 | Alexion Pharmaceuticals, Inc. | Procedes permettant de reduire le rejet suraigu d'heterogreffes |
WO1996028967A1 (fr) * | 1995-03-17 | 1996-09-26 | Chihiro Koike | Mammiferes transgeniques autres que des primates, ou des serotypes de primates superieurs ont ete exprimes par un transfert de genes etrangers et procede pour creer ceux-ci |
WO2000046355A2 (fr) * | 1999-02-04 | 2000-08-10 | Geron Corporation | Sequences de regulation transcriptionnelle de la transcriptase inverse de la telomerase |
-
2002
- 2002-03-21 WO PCT/CA2002/000378 patent/WO2002074948A2/fr active IP Right Grant
- 2002-03-21 AU AU2002242538A patent/AU2002242538B2/en not_active Ceased
- 2002-03-21 EP EP02708083A patent/EP1373498A2/fr not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995028412A1 (fr) * | 1994-04-13 | 1995-10-26 | Biotransplant, Inc. | PORC NEGATIF POUR L'α(1,3) GALACTOSYLTRANFERASE |
WO1995034202A1 (fr) * | 1994-06-15 | 1995-12-21 | Alexion Pharmaceuticals, Inc. | Procedes permettant de reduire le rejet suraigu d'heterogreffes |
WO1996028967A1 (fr) * | 1995-03-17 | 1996-09-26 | Chihiro Koike | Mammiferes transgeniques autres que des primates, ou des serotypes de primates superieurs ont ete exprimes par un transfert de genes etrangers et procede pour creer ceux-ci |
WO2000046355A2 (fr) * | 1999-02-04 | 2000-08-10 | Geron Corporation | Sequences de regulation transcriptionnelle de la transcriptase inverse de la telomerase |
Non-Patent Citations (3)
Title |
---|
CHEN CHAO-GUANG ET AL: "Reduction in Gal-alpha-1,3-Gal epitope expression in transgenic mice expressing human H-transferase.", XENOTRANSPLANTATION, vol. 3, no. 1 PART 2, 1996, pages 69 - 75, XP000909895, ISSN: 0908-665X * |
SHINKEL T A ET AL: "CHANGES IN CELL SURFACE GLYCOSYLATION IN ALPHA1,3-GALACTOSYLTRANSFER ASE KNOCKOUT AND ALPHA1,2-FUCOSYLTRANSFERASE TRANSGENIC MICE", TRANSPLANTATION, WILLIAMS AND WILKINS, BALTIMORE, MD, US, vol. 64, no. 2, 27 July 1997 (1997-07-27), pages 197 - 204, XP002922202, ISSN: 0041-1337 * |
SUMIYAMA KENTA ET AL: "Gene diversity of chimpanzee ABO blood group genes elucidated from exon 7 sequences.", GENE (AMSTERDAM), vol. 259, no. 1-2, 2000, pages 75 - 79, XP002206147, ISSN: 0378-1119 * |
Also Published As
Publication number | Publication date |
---|---|
AU2002242538B2 (en) | 2007-06-28 |
EP1373498A2 (fr) | 2004-01-02 |
WO2002074948A2 (fr) | 2002-09-26 |
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