WO2002074432A2 - Procede servant a deposer des substances chimiques - Google Patents

Procede servant a deposer des substances chimiques Download PDF

Info

Publication number
WO2002074432A2
WO2002074432A2 PCT/EP2002/002937 EP0202937W WO02074432A2 WO 2002074432 A2 WO2002074432 A2 WO 2002074432A2 EP 0202937 W EP0202937 W EP 0202937W WO 02074432 A2 WO02074432 A2 WO 02074432A2
Authority
WO
WIPO (PCT)
Prior art keywords
punctiform
points
protective layer
pits
data carrier
Prior art date
Application number
PCT/EP2002/002937
Other languages
German (de)
English (en)
Other versions
WO2002074432A3 (fr
Inventor
Ulrich Rexhausen
Manfred Wick
Original Assignee
Lifebits Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lifebits Ag filed Critical Lifebits Ag
Publication of WO2002074432A2 publication Critical patent/WO2002074432A2/fr
Publication of WO2002074432A3 publication Critical patent/WO2002074432A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00385—Printing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00436—Maskless processes
    • B01J2219/00441—Maskless processes using lasers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00536—Sheets in the shape of disks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Definitions

  • the invention relates to a method with which chemical substances can be applied to punctiform locations on an optical data carrier.
  • the chemical substances should then be used for certain detection reactions.
  • the dimensions of the spots on which the biochemical material is applied are determined by the accuracy of the application technology. It is not possible to produce sharply defined spots with a diameter of less than one micron. So far, it has not been possible, for example, to use an optical data carrier for a detection reaction, which can be processed using the existing technology for reading CDs (compact discs). The known and proven technology for reading CDs would, however, offer itself for the evaluation of detection reactions.
  • CD-ROM Equally suitable as the CD are their further developments, such as CD-ROM, CD-R and DVD as well as magneto-optical and magnetic carriers.
  • CD-ROM Compact Disc-ROM, CD-R and DVD
  • magneto-optical and magnetic carriers are their further developments, such as magneto-optical and magnetic carriers.
  • CD-ROM Compact Disc-ROM, CD-R and DVD as well as magneto-optical and magnetic carriers.
  • CD-R magneto-optical and magnetic carriers.
  • CD-R magneto-optical and magnetic carriers
  • the invention has for its object to provide a way to apply chemical substances on an optical data carrier in a size corresponding to the size of the pits of conventional CDs, with which bio-chemical reactions can then be carried out.
  • the invention proposes a method with the features mentioned in claim 1. Further training of the Invention are the subject of dependent claims, the wording of which, like the wording of the abstract, is made by reference to the content of the description.
  • Optical data carriers for example CDs, have a mirrored surface on which the laser beam used for reading is reflected.
  • So-called pits are arranged in a predetermined track within the plane, that is to say depressions with a size of approximately 0.9 to 0.6 micrometers.
  • So-called lands i.e. places where the mirroring is not disturbed, lie in the track between the pits.
  • the invention now proposes to address punctiform locations the size of pits in such a track.
  • the desired chemical substances can then be applied to the non-mirrored areas, for example with the aid of contact pressure. It is also conceivable to precede a partial mirroring before the chemical substances are applied.
  • the chemical substances are then arranged at locations that are in the track and that can be read out by an optical reading device. This makes it possible to use known technologies to evaluate the reactions.
  • Punctiform places are understood to mean those places which are in the order of magnitude of the pits of a CD (compact disc) or less. Such places do not have to be round, but can also have a substantially square, rectangular or other shape.
  • the punctiform points preferably have dimensions in the micrometer range, for example diameters between 0.5 to 2.5 ⁇ m. Another example is a size of 0.6 x 0.9 ⁇ m or smaller.
  • the point-like locations can be locations that are raised above the surface of the optical data carrier. These spots can be printed with the desired chemical substance in a particularly simple manner without further measures by means of contact printing.
  • the punctiform points to be provided with the chemical substances lie in the surface of the optical data carrier.
  • a stamping process is used here to apply the protective layer.
  • a lacquer is used as the protective layer.
  • a lacquer that prevents mirroring is used. It is possible to use a varnish that takes on the mirror coating, but also removes the mirror coating after it has been removed. However, it is particularly favorable if a lacquer is used which does not accept the mirroring, to which the mirroring layer does not adhere.
  • the punctiform points are coated with linkers.
  • linkers are molecules that bind to the surface, in particular to the polycarbonate surface, of conventional optical data carriers.
  • the punctiform points are arranged along a track which has additional punctiform points for guiding an optical scanning. These can be deepening but also increasing.
  • signaling elements are applied after the chemical reaction. These can be so-called beads, for example.
  • Fig. 14 shows another way of producing a
  • FIG. 16 shows a second possibility of forming the punctiform points
  • Fig. 17 shows a third way of forming the punctiform points.
  • Figure 1 shows schematically and simplified a cross section through a glass master 1, which is coated on one side with a photoresist 2. This forms the output for the creation of a master.
  • Layer 2 of the photoresist is exposed with the aid of a controlled laser, the laser beam exposing point-like locations which are arranged along a spiral line. This forms the original spiral shown schematically in FIG. 2.
  • a father 3 (see FIG. 3) is produced by nickel deposition, which thus represents a negative of the structure of FIG. 2.
  • a further nickel deposition produces a mother structure 4 from the father 3, see FIG. 4.
  • a son structure 5 is produced from the mother structure 4 by a further deposition process. Any number of son structures 5 can be produced.
  • This son structure 5 is used to manufacture support structures 6 in the form of blank CDs with the aid of injection molding processes, on which all pits are present. This is shown in Figure 6. Any number of supports 6 can also be generated from any number of son structures 5.
  • FIG. 7 shows how a glass master coated with so-called negative photoresist is exposed by the glass master 1 shown in FIG. This results in a (“inverted”) negative substrate 7, which is shown in FIG. 7 above the glass master 1.
  • Photoresist layer 10 of another substrate 11 partially exposed (see
  • FIG. 9 From this further substrate 11, which is a first submaster represents, a negative for a silicone stamp is produced by depositing nickel stamps or by renewed electroforming.
  • This stamp 12 is shown in FIG. 9. It contains a subset of elevations 13, which are intended for contacting specific subsets of elevations 14 of the measuring carriers 6 shown in FIG.
  • detector molecules By aligning the punches 12 with the measuring carriers 6 in an aligned manner, detector molecules can be applied to certain elevations or pits of the measuring carrier.
  • a large number of stamps which are produced with the help of many submasters, a wide variety of detector materials can be applied to the different subsets of pits.
  • a measuring carrier provided with the detector molecules can then be wetted with a sample to be examined, which depending on the selection of the sample and / or the detector molecules leads to the various chemical or physical processes
  • FIGS. 10 and 11 show an embodiment in which a negative substrate 15 is produced through the master master after coating with negative photoresist and exposure.
  • a negative substrate 18, mirror-image spiral, is produced from the negative substrate 15 by exposure.
  • This negative substrate 18 is used in a similar way to produce a son substrate 16, see FIG. 12, with the aid of which an inverse CD 17 can be produced by injection molding.
  • the pits protrude from the side of the CD facing away from the laser.
  • a further substrate can be produced with the original spiral by exposure to a positive photoresist.
  • This can be according to figures 8 and 9 are further processed into masters 18 for silicone stamps, which subsets of the "negative" pits protruding from the CD can address.
  • an etching mask is created by congruent mastering, which addresses defined subsets of lands. Applying a photo-resistive layer to a son and then exposing it through the congruent etching mask subsequently permits targeted etching of the son.
  • FIG. 13 shows in more detail an alternative method step to the method shown in FIG. 8.
  • a laser double head 20 contains two permanently connected laser heads.
  • a laser head is used to generate a weak reading beam, represented by the double arrow 21. This reading beam 21 reads out the negatively oriented CD master 22.
  • the laser head 20 contains a second strong laser, which generates a write beam 23 in a controlled manner. This write beam 23 can be switched on and off by the logic of the double head 20.
  • a connected computer searches for the subset of the master's pits to be copied and controls the read-write logic.
  • the fixed coupling of the two laser heads in conjunction with a definition of a parallel alignment to the axis of rotation, ensures a spatial 1: 1 structure of the subset structure of the pits.
  • the actual procedure for manipulating the stamp consists in the hardening or the introduction of suitable material into the master stamp structure 24, which on the Underside of a stamp holder 25 is held for example by negative pressure.
  • Material present on the underside of the stamp holder 25, for example plastic material 26, is cured by exposure to the writing beam 23. After the subset of pits has been written completely, the excess material 26 is removed, for example by rinsing with solvent. Tracking is only in the reading direction, since both heads are rigidly connected and the entire head is moved. The focus is adjusted in both arms.
  • FIG. 14 shows a device which is similar to the device according to FIG. 13. It is used here to make a positive sub-copy of a CD master. Connected by the axis 27, the CD master 22 and the sub copy 28 of the CD master to be produced rotate synchronously with one another. The side of the copy 28 facing the laser head 20 is coated with a layer 29 of photoresist which can be exposed by the writing beam 23. A connected computer searches for the subgroup of the master CD pits to be copied and controls the read-write logic. Attention is paid to an adapted focus size of the two beams, namely the reading beam 21 and the writing beam 23. With the same size of the focus of the two beams, this results in a 1: 1 copy of the pits.
  • FIG. 15 again shows a section through an optical data carrier on an enlarged scale.
  • the pits 41 are raised here relative to the surface 40.
  • a coating 43 is applied to the surface of one of the pits 42, which ensures that this surface remains free of mirroring when mirroring.
  • a certain chemical substance is then printed on the surface of this pit. Since the surface of the pit 42 is raised, the printing can be done relatively easily.
  • the pits 41 are formed as usual as depressions.
  • a lacquer layer 43 is applied, which then, when mirroring from above, ensures that this point remains free of mirroring.
  • the chemical substance is then printed on here, similar to the embodiment according to FIG. After attaching a signaling element such. B. beads and subsequent mirroring also creates a place where the mirroring is disturbed.
  • Figure 17 shows a possibility similar to Figure 16.
  • an elevation 45 protruding from the plane 40 is formed, which can then be provided with a lacquer layer in the same way as in the embodiment according to FIG. After removing the lacquer layer, an unmirrored area is produced here, which can be used for printing with the chemical substance.

Abstract

L'invention a pour objet la mise en évidence de réactions chimiques. A cet effet, sur un support de données optique, des zones ponctuelles ayant la taille des trous d'un CD conventionnel sont tout d'abord recouvertes d'un vernis, puis la totalité de la surface est rendue réfléchissante. Après élimination de la couche de vernis, les zones ponctuelles sont alors disponibles et peuvent recevoir une substance chimique par impression. En tant que procédé d'impression est utilisée une impression par contact.
PCT/EP2002/002937 2001-03-16 2002-03-16 Procede servant a deposer des substances chimiques WO2002074432A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2001113712 DE10113712A1 (de) 2001-03-16 2001-03-16 Verfahren zum Aufbringen chemischer Substanzen
DE10113712.5 2001-03-16

Publications (2)

Publication Number Publication Date
WO2002074432A2 true WO2002074432A2 (fr) 2002-09-26
WO2002074432A3 WO2002074432A3 (fr) 2003-02-13

Family

ID=7678367

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/002937 WO2002074432A2 (fr) 2001-03-16 2002-03-16 Procede servant a deposer des substances chimiques

Country Status (2)

Country Link
DE (1) DE10113712A1 (fr)
WO (1) WO2002074432A2 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028623A1 (fr) * 1996-12-20 1998-07-02 Gamera Bioscience Corporation Systeme a base de liaisons par affinite permettant de detecter des particules dans un fluide
WO1999035499A1 (fr) * 1997-12-30 1999-07-15 Remacle Jose Procede mettant en oeuvre une molecule de capture fixee sur la surface d'un disque
WO2000020861A1 (fr) * 1998-10-05 2000-04-13 Commissariat A L'energie Atomique Biopuce et dispositif de lecture d'une biopuce comportant une pluralite de zones de reconnaissance moleculaire
WO2000026677A1 (fr) * 1998-10-30 2000-05-11 Burstein Laboratories, Inc. Disques optiques lisibles portant un materiau analyte pouvant etre lu simultanement
WO2001018242A1 (fr) * 1999-09-08 2001-03-15 Institut für Physikalische Hochtechnologie e.V. Capteur d'affinite pour la detection d'especes biologiques et/ou chimiques, et son utilisation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981783A (en) * 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
US5731152A (en) * 1996-05-13 1998-03-24 Motorola, Inc. Methods and systems for biological reagent placement
US6368877B1 (en) * 1997-06-25 2002-04-09 Massachusetts Institute Of Technology Self-assembling peptide surfaces for cell patterning and interactions
DE19818999A1 (de) * 1998-04-28 2000-01-20 Biotechnolog Forschung Gmbh Vorrichtung zur Erzeugung von frei definierbaren Repertoires

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028623A1 (fr) * 1996-12-20 1998-07-02 Gamera Bioscience Corporation Systeme a base de liaisons par affinite permettant de detecter des particules dans un fluide
WO1999035499A1 (fr) * 1997-12-30 1999-07-15 Remacle Jose Procede mettant en oeuvre une molecule de capture fixee sur la surface d'un disque
WO2000020861A1 (fr) * 1998-10-05 2000-04-13 Commissariat A L'energie Atomique Biopuce et dispositif de lecture d'une biopuce comportant une pluralite de zones de reconnaissance moleculaire
WO2000026677A1 (fr) * 1998-10-30 2000-05-11 Burstein Laboratories, Inc. Disques optiques lisibles portant un materiau analyte pouvant etre lu simultanement
WO2001018242A1 (fr) * 1999-09-08 2001-03-15 Institut für Physikalische Hochtechnologie e.V. Capteur d'affinite pour la detection d'especes biologiques et/ou chimiques, et son utilisation

Also Published As

Publication number Publication date
DE10113712A1 (de) 2002-09-26
WO2002074432A3 (fr) 2003-02-13

Similar Documents

Publication Publication Date Title
DE69928474T2 (de) Optiche sonde für nahfeld-messungen
DE69730149T2 (de) Kontaktkopierverfahren auf einem mit gold beschichteten film
DE3511712C2 (de) Plattenförmiger Informationsträger und Verfahren zu seiner Herstellung
DE69830530T2 (de) Verfahren zum Formen von sichtbaren Bildinformationen
DE3719200A1 (de) Optische speicherplatte und verfahren zu ihrer herstellung
DE3504969C2 (fr)
DE19830293A1 (de) Stempel für optische Disks und Verfahren/Systeme zur Herstellung der Stempel
EP0373329B1 (fr) Procédé de fabrication lithographique de microstructures formables par voie galvanique à coupe transversale triangulaire ou trapézoidale
DE3042101C2 (de) Substrat für Aufzeichnungsmedien und Verfahren zu seiner Herstellung
WO2002074432A2 (fr) Procede servant a deposer des substances chimiques
DE102010043059A1 (de) Imprinttemplate, Nanoimprintvorrichtung und Nanostrukturierungsverfahren
DE112007001503B4 (de) Kügelchen-Immobilisierungsverfahren und dadurch gebildete Kügelchen-Arrays
DE19935775A1 (de) Datenspeicher und Verfahren zum Schreiben von Information in einen Datenspeicher
WO2002075734A2 (fr) Procede et dispositif permettant la realisation de copies geometriquement precises de sous-ensembles de zones ponctuelles
DE60221942T2 (de) Verfahren zur Herstellung lichterzeugender Nahfeld-Elemente
DE2212968C3 (de) Verfahren zum Aufzeichnen eines Deformationsbildes
WO2002074433A2 (fr) Procede et dispositifs servant a deposer des reactifs sur des zones ponctuelles
DE60101744T2 (de) Verfahren zum Herstellen eines für ein Matrizenherstellungsverfahren geeigneten Substrats und durch das Verfahren erhaltenes Substrat
EP0302374A2 (fr) Dispersion, couche de dispersion bistable réversible préparée à partir de celle-ci
EP1050875A2 (fr) Fabrication d'une matrice de pressage pour disques compacts
DE102018132786A1 (de) Verfahren und Vorrichtung zur Herstellung eines computergenerierten Hologramms, Hologramm sowie Beleuchtungsvorrichtung für ein Fahrzeug
EP0286938B1 (fr) Supports d'enrégistrement optique irréversible et procédé de fabrication
EP0292675B1 (fr) Supports d'enregistrement optique irréversible et procédés de fabrication
WO1998058293A2 (fr) Procede et dispositif d'immobilisation de macromolecules
DE3604237C2 (fr)

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: FESTSTELLUNG EINES RECHTSVERLUSTS NACH REGEL 69(1)EPUE

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP