Classifications

• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
  • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
  • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
  • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
  • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
  • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
  • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
  • B01L3/50255—Multi-well filtration
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L9/00—Supporting devices; Holding devices
  • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
  • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
  • B01L2200/02—Adapting objects or devices to another
  • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
  • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L2300/00—Additional constructional details
  • B01L2300/06—Auxiliary integrated devices, integrated components
  • B01L2300/0681—Filter
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L2300/00—Additional constructional details
  • B01L2300/08—Geometry, shape and general structure
  • B01L2300/0809—Geometry, shape and general structure rectangular shaped
  • B01L2300/0822—Slides
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L2400/00—Moving or stopping fluids
  • B01L2400/04—Moving fluids with specific forces or mechanical means
  • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
  • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces

Definitions

• H H- 13 03 ⁇ 0 ⁇ ⁇ ⁇ ⁇ ⁇ tQ ⁇ 0 ⁇ ⁇ 3 ⁇ ⁇ ! 3 ⁇ i ⁇ rt ⁇ ⁇ 13 * t-> ⁇ ii •d M Ml ⁇ - ⁇ ft ) 03 Mi r rt 0 ⁇ ii ⁇ ⁇ rt ii
• Figs. 2 and 3 show a device for holding the substrate 1 during performing an assay.
• the device 5 comprises upper and lower plates 6,7, wherein in the embodiment shown each plate 6,7 is provided with an array of four openings 8,9.
• the upper and lower plates 6,7 are made of a suitable plastic material in an injection moulding process for example.
• the upper and lower plates 6,7 are adapted to receive the substrate 1 sandwiched in the interface 10 between the plates 6,7.
• the openings 8,9 are partially aligned, wherein the axes of openings 9 in the lower plate 7 are staggered with respect to the axes of openings 8 in the upper plate 6.
• each opening 8 of the upper plate 6 is surrounded by an upwardly projecting rim 11 and each opening 9 in the lower plate 7 is surrounded by a downwardly projecting rim 12.
• the openings 8,9 are circular and the rims 11,12 are made as cylindrical structures.
• Each shielding member 13 has a wedge-shaped cross-section in the embodiment shown having a preferably flat upper surface 14 inclined with respect to the interface 10 of the plates 6,7. In this manner a fluid passing through the capillary channels will gradually contact the upper surface 14 from the left to right according to the cross- section of fig. 3 thus avoiding enclosing of air bubbles.
• the angle of inclination of the upper surface 14 of the shielding member 13 is preferably at least 5°.
• the staggering of the lower openings 9 with respect to the upper openings 8 allows for a complete screening of the openings 9 if the device 5 is viewed from the top side. In this manner a real time reading of the areas 4 of the substrate 1 is possible when the sample fluid is fully transported to the lower side of the sub- strate 1. Any background signal caused by free label in the sample fluid under the substrate 1 is avoided.
• the shape of the shielding member 13 with the inclined upper surface 14 further improves the mixing of the sample fluid during transporting the sample fluid through the capil- lary channels of the substrate 1.

Landscapes

• Chemical & Material Sciences (AREA)
• Health & Medical Sciences (AREA)
• Analytical Chemistry (AREA)
• Clinical Laboratory Science (AREA)
• Chemical Kinetics & Catalysis (AREA)
• General Health & Medical Sciences (AREA)
• Hematology (AREA)
• Dispersion Chemistry (AREA)
• Automatic Analysis And Handling Materials Therefor (AREA)
• Dram (AREA)
• Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
• Reinforced Plastic Materials (AREA)
• External Artificial Organs (AREA)
• Container, Conveyance, Adherence, Positioning, Of Wafer (AREA)
• Devices For Use In Laboratory Experiments (AREA)
• Apparatus Associated With Microorganisms And Enzymes (AREA)

Priority Applications (3)

Applications Claiming Priority (2)

Publications (1)

Family

ID=8180010

Family Applications (1)

Country Status (6)

Families Citing this family (1)

Citations (7)

• 2002
  • 2002-03-05 ES ES02724203T patent/ES2266488T3/es not_active Expired - Lifetime
  • 2002-03-05 EP EP02724203A patent/EP1370360B1/de not_active Expired - Lifetime
  • 2002-03-05 JP JP2002571220A patent/JP2004531707A/ja not_active Ceased
  • 2002-03-05 WO PCT/EP2002/002446 patent/WO2002072268A1/en active IP Right Grant
  • 2002-03-05 AT AT02724203T patent/ATE328665T1/de not_active IP Right Cessation
  • 2002-03-05 DE DE60212089T patent/DE60212089T2/de not_active Expired - Lifetime

Patent Citations (7)

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