WO2002068621A3 - Rax-related protein - Google Patents

Rax-related protein Download PDF

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Publication number
WO2002068621A3
WO2002068621A3 PCT/US2002/006179 US0206179W WO02068621A3 WO 2002068621 A3 WO2002068621 A3 WO 2002068621A3 US 0206179 W US0206179 W US 0206179W WO 02068621 A3 WO02068621 A3 WO 02068621A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
rax
protein
provides
cdna
Prior art date
Application number
PCT/US2002/006179
Other languages
French (fr)
Other versions
WO2002068621A2 (en
Inventor
Preeti G Lal
Henry Yue
Original Assignee
Incyte Genomics Inc
Preeti G Lal
Henry Yue
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Preeti G Lal, Henry Yue filed Critical Incyte Genomics Inc
Priority to AU2002248517A priority Critical patent/AU2002248517A1/en
Publication of WO2002068621A2 publication Critical patent/WO2002068621A2/en
Publication of WO2002068621A3 publication Critical patent/WO2002068621A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity

Abstract

The invention provides cDNA which encodes a RAX-related protein. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly liposarcoma, mesentery mixed-mullerian tumor, spinal schwannoma, gallbladder cancer, prostate cancer, brain astrocytoma, lung cancer, and bladder cancer, and Crohn's disease. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
PCT/US2002/006179 2001-02-26 2002-02-26 Rax-related protein WO2002068621A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002248517A AU2002248517A1 (en) 2001-02-26 2002-02-26 Rax-related protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79384001A 2001-02-26 2001-02-26
US09/793,840 2001-02-26

Publications (2)

Publication Number Publication Date
WO2002068621A2 WO2002068621A2 (en) 2002-09-06
WO2002068621A3 true WO2002068621A3 (en) 2003-12-18

Family

ID=25160944

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/006179 WO2002068621A2 (en) 2001-02-26 2002-02-26 Rax-related protein

Country Status (2)

Country Link
AU (1) AU2002248517A1 (en)
WO (1) WO2002068621A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858675A (en) * 1997-05-13 1999-01-12 Incyte Pharmaceuticals, Inc. Double-stranded RNA-binding protein
WO1999015658A2 (en) * 1997-09-23 1999-04-01 Incyte Pharmaceuticals, Inc. Human regulatory molecules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858675A (en) * 1997-05-13 1999-01-12 Incyte Pharmaceuticals, Inc. Double-stranded RNA-binding protein
WO1999015658A2 (en) * 1997-09-23 1999-04-01 Incyte Pharmaceuticals, Inc. Human regulatory molecules
US6132973A (en) * 1997-09-23 2000-10-17 Incyte Pharmaceuticals, Inc. Human regulatory molecules

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
[online] 13 June 1997 (1997-06-13), HILLIER ET AL: "WashU-Merck EST project 1997", XP002237671, retrieved from EBI accession no. HS1256257 Database accession no. AA461277 *
[online] 14 December 2000 (2000-12-14), BONALDO ET AL: "Normalization and subtraction: two approaches to facilitate gene discovery", XP002237673, retrieved from EBI accession no. BF549034 Database accession no. BF549034 *
[online] 2 February 2001 (2001-02-02), STRAUSBERG: "National Institutes of Health, Mammalian Gene Collection", XP002237672, retrieved from EBI accession no. BG107958 Database accession no. BG107958 *
RUVOLO ET AL: "Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAX", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, 8 January 2001 (2001-01-08), pages 11754 - 11758, XP002236908 *
WANG ET AL: "Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome", SCIENCE, vol. 280, 1998, pages 1077 - 1082, XP002089398, ISSN: 0036-8075 *

Also Published As

Publication number Publication date
WO2002068621A2 (en) 2002-09-06
AU2002248517A1 (en) 2002-09-12

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