WO2002024742A3 - Atp-binding cassette protein - Google Patents

Atp-binding cassette protein Download PDF

Info

Publication number
WO2002024742A3
WO2002024742A3 PCT/US2001/029455 US0129455W WO0224742A3 WO 2002024742 A3 WO2002024742 A3 WO 2002024742A3 US 0129455 W US0129455 W US 0129455W WO 0224742 A3 WO0224742 A3 WO 0224742A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
atp
binding cassette
breast
provides
Prior art date
Application number
PCT/US2001/029455
Other languages
French (fr)
Other versions
WO2002024742A2 (en
Inventor
Randi E Krasnow
Mariah R Baughn
Original Assignee
Incyte Genomics Inc
Randi E Krasnow
Mariah R Baughn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Randi E Krasnow, Mariah R Baughn filed Critical Incyte Genomics Inc
Priority to AU2001292873A priority Critical patent/AU2001292873A1/en
Priority to CA002422508A priority patent/CA2422508A1/en
Priority to EP01973276A priority patent/EP1319021A2/en
Publication of WO2002024742A2 publication Critical patent/WO2002024742A2/en
Publication of WO2002024742A3 publication Critical patent/WO2002024742A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention provides a mammalian cDNA which encodes a mammalian ATP-binding cassette protein. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of breast disorders, particularly breast proliferative fibrocystic disease, breast adenocarcinoma, and drug resistance. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
PCT/US2001/029455 2000-09-22 2001-09-20 Atp-binding cassette protein WO2002024742A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2001292873A AU2001292873A1 (en) 2000-09-22 2001-09-20 Atp-binding cassette protein
CA002422508A CA2422508A1 (en) 2000-09-22 2001-09-20 Atp-binding cassette protein
EP01973276A EP1319021A2 (en) 2000-09-22 2001-09-20 Atp-binding cassette protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66862800A 2000-09-22 2000-09-22
US09/668,628 2000-09-22

Publications (2)

Publication Number Publication Date
WO2002024742A2 WO2002024742A2 (en) 2002-03-28
WO2002024742A3 true WO2002024742A3 (en) 2003-04-03

Family

ID=24683122

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/029455 WO2002024742A2 (en) 2000-09-22 2001-09-20 Atp-binding cassette protein

Country Status (4)

Country Link
EP (1) EP1319021A2 (en)
AU (1) AU2001292873A1 (en)
CA (1) CA2422508A1 (en)
WO (1) WO2002024742A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001032706A2 (en) * 1999-11-02 2001-05-10 Lexicon Genetics Incorporated Novel human transporter proteins and polynucleotides encoding the same
AU2003213672A1 (en) * 2002-03-04 2003-09-22 Avalon Pharmaceuticals Cancer-linked gene as target for chemotherapy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000036101A2 (en) * 1998-11-30 2000-06-22 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services An atp-binding cassette protein responsible for cytotoxin resistance
WO2001032706A2 (en) * 1999-11-02 2001-05-10 Lexicon Genetics Incorporated Novel human transporter proteins and polynucleotides encoding the same
WO2001057214A2 (en) * 2000-02-03 2001-08-09 Lexicon Genetics Incorporated Human transporter proteins and polynucleotides encoding the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000036101A2 (en) * 1998-11-30 2000-06-22 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services An atp-binding cassette protein responsible for cytotoxin resistance
WO2001032706A2 (en) * 1999-11-02 2001-05-10 Lexicon Genetics Incorporated Novel human transporter proteins and polynucleotides encoding the same
WO2001057214A2 (en) * 2000-02-03 2001-08-09 Lexicon Genetics Incorporated Human transporter proteins and polynucleotides encoding the same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ALLIKMETS R ET AL: "CHARACTERIZATION OF THE HUMAN ABC SUPERFAMILY: ISOLATION AND MAPPING OF 21 NEW GENES USING THE EXPRESSED SEQUENCE TAGS DATABASE", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 5, no. 10, 1996, pages 1649 - 1655, XP002074412, ISSN: 0964-6906 *
DOYLE L A ET AL: "A MULTIDRUG RESISTANCE TRANSPORTER FROM HUMAN MCF-7 BREAST CANCER CELLS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, December 1998 (1998-12-01), pages 15665 - 15670, XP001055044, ISSN: 0027-8424 *
YANG D L A ET AL: "CLONING AND CHARACTERIZATION OF BREAST CANCER RESISTANCE PROTEIN (BCRP), A NOVEL ATP-BINDING CASSETTE (ABC) TRANSPORTER THAT MAY CONTRIBUTE TO THE MULTIDRUG-RESISTANCE PHENOTYPE OF MCF-7/ADRVP BREAST CANCER CELLS", PROCEEDINGS OF THE 89TH. ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. NEW ORLEANS, LA, MARCH 28 - APRIL 1, 1998, PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, PHILADELPHIA, PA: AACR, US, vol. 39, 28 March 1998 (1998-03-28), pages 657, XP000891682 *

Also Published As

Publication number Publication date
CA2422508A1 (en) 2002-03-28
EP1319021A2 (en) 2003-06-18
AU2001292873A1 (en) 2002-04-02
WO2002024742A2 (en) 2002-03-28

Similar Documents

Publication Publication Date Title
WO2005062972A3 (en) Treatment of cancer with novel anti-il 13 monoclonal antibodies
WO2004110472A3 (en) Fusion proteins
WO2001068859A3 (en) Il-17 receptor like molecules and uses thereof
WO2002086076A3 (en) Polynucleotides and polypeptides associated with the nf-kb pathway
WO2002072751A3 (en) Polynucleotides encoding a metalloprotease, mp-1
WO2002008399A3 (en) Human kinases
WO2001071357A3 (en) Diagnosis and treatment of breast cancer
HUP0300054A1 (en) Tumour-specific animal proteins
WO2000061756A3 (en) Compounds for immunotherapy and diagnosis of breast cancer and methods for their use
WO2002004513A3 (en) Down syndrome critical region 1-like 1 proteins
WO2002059311A3 (en) Colon cancer marker
WO2002024742A3 (en) Atp-binding cassette protein
WO2002002772A3 (en) Human extracellular matrix (ecm)-related tumor marker
WO2003027231A3 (en) Polynucleotide encoding adapter protein, pmn29
WO2000061753A3 (en) Compositions and methods for the treatment and diagnosis of breast cancer
WO2002053719A3 (en) Cytoskeleton-associated proteins
WO1998059041A3 (en) Disease related nucleotide kinases
WO2001083524A3 (en) Rna metabolism proteins
WO2001046443A3 (en) Proteases
WO2002055706A3 (en) Asip-related proteins
WO2002042330A3 (en) Cystoskeleton-associated proteins
WO2001055391A3 (en) 84p2a9: a prostate and testis specific protein highly expressed in prostate cancer
WO2003061601A3 (en) Aminophospholipid transporter atpase
WO2001046256A3 (en) Vesicle trafficking proteins
WO2002090991A3 (en) Proteins and genes for diagnosis and treatment of erbb2-related cancer

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2001973276

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2422508

Country of ref document: CA

WWP Wipo information: published in national office

Ref document number: 2001973276

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 2001973276

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP