WO2002067669A3 - Production d une lignee germinale d'oiseaux fondee sur une cellule germinale primordiale - Google Patents

Production d une lignee germinale d'oiseaux fondee sur une cellule germinale primordiale Download PDF

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Publication number
WO2002067669A3
WO2002067669A3 PCT/US2002/000429 US0200429W WO02067669A3 WO 2002067669 A3 WO2002067669 A3 WO 2002067669A3 US 0200429 W US0200429 W US 0200429W WO 02067669 A3 WO02067669 A3 WO 02067669A3
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WO
WIPO (PCT)
Prior art keywords
cell
birds
nucleic acid
line production
gonadal
Prior art date
Application number
PCT/US2002/000429
Other languages
English (en)
Other versions
WO2002067669A2 (fr
Inventor
Alexander Baguisi
Karl M Ebert
Original Assignee
Tranxenogen Inc
Alexander Baguisi
Karl M Ebert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tranxenogen Inc, Alexander Baguisi, Karl M Ebert filed Critical Tranxenogen Inc
Priority to JP2002567051A priority Critical patent/JP2005507234A/ja
Priority to CA002438612A priority patent/CA2438612A1/fr
Priority to EP02723043A priority patent/EP1361788A2/fr
Publication of WO2002067669A2 publication Critical patent/WO2002067669A2/fr
Publication of WO2002067669A3 publication Critical patent/WO2002067669A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/0611—Primordial germ cells, e.g. embryonic germ cells [EG]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/30—Bird
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/235—Leukemia inhibitory factor [LIF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • Environmental Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention se rapporte à une cellule gonadique aviaire isolée, par ex. une cellule ovarienne ou une cellule testiculaire, contenant un acide nucléique hétérologue, ainsi qu'à une méthode destinée à introduire une molécule d'acide nucléique dans le génome d'une espèce aviaire et qui consiste à mettre une population de cellules gonadiques isolées dérivées d'un embryon de poulet en contact avec la molécule d'acide nucléique afin de produire des cellules gonadiques transfectées, et à transférer les cellules gonadiques transfectées dans un ovocyte fécondé.
PCT/US2002/000429 2001-02-16 2002-01-11 Production d une lignee germinale d'oiseaux fondee sur une cellule germinale primordiale WO2002067669A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2002567051A JP2005507234A (ja) 2001-02-16 2002-01-11 始原生殖細胞ベースの、鳥の生殖細胞系の作製
CA002438612A CA2438612A1 (fr) 2001-02-16 2002-01-11 Production d une lignee germinale d'oiseaux fondee sur une cellule germinale primordiale
EP02723043A EP1361788A2 (fr) 2001-02-16 2002-01-11 Production d'une lignee germinale d'oiseaux fondee sur une cellule germinale primordiale

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26944201P 2001-02-16 2001-02-16
US69442701A 2001-02-16 2001-02-16
US60/269,442 2001-02-16

Publications (2)

Publication Number Publication Date
WO2002067669A2 WO2002067669A2 (fr) 2002-09-06
WO2002067669A3 true WO2002067669A3 (fr) 2003-02-27

Family

ID=29250345

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/000429 WO2002067669A2 (fr) 2001-02-16 2002-01-11 Production d une lignee germinale d'oiseaux fondee sur une cellule germinale primordiale

Country Status (4)

Country Link
EP (1) EP1361788A2 (fr)
JP (1) JP2005507234A (fr)
CA (1) CA2438612A1 (fr)
WO (1) WO2002067669A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106070010A (zh) * 2016-06-15 2016-11-09 上海市农业科学院 一种黑羽蛋鸡配套系父本的育种方法及其配套系的制种模式

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1590435B1 (fr) * 2003-01-16 2008-03-19 North Carolina State University Depletion de cellules germinales embryonnaires endogenes dans des espaces aviaires
KR100569168B1 (ko) * 2003-08-08 2006-04-07 (주)아비코아생명공학연구소 조류 정원줄기세포의 배양방법 및 이에 의해 수득한 조류정원줄기세포
US20060174362A1 (en) * 2005-02-01 2006-08-03 Origen Therapeutics, Inc. Long-term culture of avian primordial germ cells (PGCs)
AU2012201824B2 (en) * 2005-02-01 2014-08-28 Synageva Biopharma Corp. Transgenic chickens
AU2006210645A1 (en) * 2005-02-01 2006-08-10 Symphogen A/S Transgenic chickens
CN111965094B (zh) * 2020-08-24 2023-10-27 扬州大学 一种比较体外诱导的PGC-like细胞迁移效率的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990011355A1 (fr) * 1989-03-17 1990-10-04 National Research Development Corporation Introduction d'un gene exogene dans des oiseaux

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990011355A1 (fr) * 1989-03-17 1990-10-04 National Research Development Corporation Introduction d'un gene exogene dans des oiseaux

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BAGUISI A ET AL: "Avian primordial germ cells: Potential for transgenesis and conservation.", THERIOGENOLOGY, vol. 57, no. 1, 2 January 2002 (2002-01-02), Proceedings of the Annual Conference of the International Embryo Transfer Society;Foz do Iguassu, Parana, Brazil; January 12-15, 2001, pages 775, XP002216115, ISSN: 0093-691X *
BRESLER M ET AL: "MANIPULATIONS OF GERM-CELL POPULATIONS IN THE GONAD OF THE FOWL", BRITISH POULTRY SCIENCE, LONGMAN GROUP, GB, vol. 35, May 1994 (1994-05-01), pages 241 - 247, XP000994671, ISSN: 0007-1668 *
EBERT K M ET AL: "Avian primordial germ cells: Potential for somatic lineage contribution.", THERIOGENOLOGY, vol. 57, no. 1, 2 January 2002 (2002-01-02), Proceedings of the Annual Conference of the International Embryo Transfer Society;Foz do Iguassu, Parana, Brazil; January 12-15, 2001, pages 564, XP002216114, ISSN: 0093-691X *
ETCHES R J ET AL: "STRATEGIES FOR THE PRODUCTION OF TRANSGENIC CHICKENS", METHODS IN MOLECULAR BIOLOGY, HUMANA PRESS INC., CLIFTON, NJ, US, vol. 62, 1997, pages 433 - 450, XP000974906 *
FURUTA H ET AL: "DEVELOPMENT OF THE GONADS DERIVED FROM HETERO-SEXUALLY TRANSFERRED PRIMORDIAL GERM CELLS (PGCS) BETWEEN EMBRYOS IN THE CHICKEN", ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, SUWEON, KR, vol. 12, December 1999 (1999-12-01), pages 1188 - 1191, XP000994668, ISSN: 1011-2367 *
NAITO M ET AL: "Expression of exogenous DNA in the gonads of chimaeric chicken embryos produced by transfer of primordial germ cells transfected in vitro and subsequent fate of the introduced DNA.", JOURNAL OF REPRODUCTION AND FERTILITY, vol. 113, no. 1, May 1998 (1998-05-01), pages 137 - 143, XP002216113, ISSN: 0022-4251 *
ONO T ET AL: "SETTLEMENT OF QUAIL PRIMORDIAL GERM CELLS IN CHICKEN GONADS", ANIMAL FEED SCIENCE AND TECHNOLOGY, AMSTERDAM, NL, vol. 69, no. 6, June 1998 (1998-06-01), pages 546 - 555, XP000994649 *
PERRY M M ET AL: "TRANSGENESIS IN CHICKENS", TRANSGENIC RESEARCH, LONDON, GB, vol. 2, no. 3, May 1993 (1993-05-01), pages 125 - 133, XP000998723, ISSN: 0962-8819 *
VICK L ET AL: "TRANSGENIC BIRDS FROM TRANSFORMED PRIMORDIAL GERM CELLS", PROCEEDINGS OF THE ROYAL SOCIETY OF EDINBURGH. SECTION B, BIOLOGICAL SCIENCES, ROYAL SOCIETY OF EDINBURGH, EDINBURGH, GB, vol. 251, no. 1332, 22 March 1993 (1993-03-22), pages 179 - 182, XP000997980, ISSN: 0269-7270 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106070010A (zh) * 2016-06-15 2016-11-09 上海市农业科学院 一种黑羽蛋鸡配套系父本的育种方法及其配套系的制种模式
CN106070010B (zh) * 2016-06-15 2018-11-16 上海市农业科学院 一种黑羽蛋鸡配套系父本的育种方法及其配套系的制种模式

Also Published As

Publication number Publication date
CA2438612A1 (fr) 2002-09-06
WO2002067669A2 (fr) 2002-09-06
JP2005507234A (ja) 2005-03-17
EP1361788A2 (fr) 2003-11-19

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