WO2002064748A3 - Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof - Google Patents
Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof Download PDFInfo
- Publication number
- WO2002064748A3 WO2002064748A3 PCT/US2002/004652 US0204652W WO02064748A3 WO 2002064748 A3 WO2002064748 A3 WO 2002064748A3 US 0204652 W US0204652 W US 0204652W WO 02064748 A3 WO02064748 A3 WO 02064748A3
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- methods
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- adult stem
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
Abstract
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IL15733202A IL157332A0 (en) | 2001-02-14 | 2002-02-14 | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
JP2002565063A JP2004529621A (en) | 2001-02-14 | 2002-02-14 | Pluripotent adult stem cells, their origin, methods of obtaining and maintaining them, methods of differentiating them, methods of their use, and cells derived therefrom |
EP02718998A EP1367899A4 (en) | 2001-02-14 | 2002-02-14 | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
NZ527527A NZ527527A (en) | 2001-02-14 | 2002-02-14 | Mammalian multipotent adult stem cells (MASC) with the capacity to differentiate into cells of mesodermal, ectodermal or endodermal origin and uses thereof |
CA2438501A CA2438501C (en) | 2001-02-14 | 2002-02-14 | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
US10/467,963 US7838289B2 (en) | 2001-02-14 | 2002-02-14 | Assay utilizing multipotent adult stem cells |
IL214623A IL214623A (en) | 2001-02-14 | 2003-08-11 | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof. methods of use thereof and cells derived therefrom |
IL157332A IL157332A (en) | 2001-02-14 | 2003-08-11 | Method for providing cell population from umbilical cord blood or placenta which can differentiate into cell types of the embryonic lineage |
ZA2003/06289A ZA200306289B (en) | 2001-02-14 | 2003-08-13 | Multipotent adult stem cells sources thereof methods of obtaining and maintaining same methods of differentiation thereof methods of use thereof and cells derived thereof |
US11/084,809 US20050283844A1 (en) | 2001-02-14 | 2005-03-21 | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
US11/587,511 US8609412B2 (en) | 1999-08-05 | 2005-04-21 | Mapc generation of lung tissue |
US11/151,689 US8075881B2 (en) | 1999-08-05 | 2005-06-13 | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
US11/269,736 US8147824B2 (en) | 1999-08-05 | 2005-11-09 | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
US11/446,560 US7927587B2 (en) | 1999-08-05 | 2006-06-02 | MAPC administration for the treatment of lysosomal storage disorders |
US12/093,159 US9962407B2 (en) | 1999-08-05 | 2006-11-09 | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
US13/042,205 US20110177595A1 (en) | 2001-02-14 | 2011-03-07 | Multipotent Adult Stem Cells, Sources Thereof, Methods of Obtaining and Maintaining Same, Methods of Differentiation Thereof, Methods of Use Thereof and Cells Derived Thereof |
US13/105,372 US8252280B1 (en) | 1999-08-05 | 2011-05-11 | MAPC generation of muscle |
IL214623A IL214623A0 (en) | 2001-02-14 | 2011-08-11 | Method for providing cell population from umbilical cord blood or placenta |
US13/301,186 US9526747B2 (en) | 1999-08-05 | 2011-11-21 | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
US13/345,036 US9808485B2 (en) | 1999-08-05 | 2012-01-06 | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
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US10467963 A-371-Of-International | 2002-02-14 | ||
US10/467,963 A-371-Of-International US7838289B2 (en) | 1999-08-05 | 2002-02-14 | Assay utilizing multipotent adult stem cells |
US10/048,757 Continuation-In-Part US7015037B1 (en) | 1999-08-05 | 2002-08-21 | Multiponent adult stem cells and methods for isolation |
US96344404A Continuation-In-Part | 1999-08-05 | 2004-10-11 | |
US10/587,511 Continuation-In-Part US20070149331A1 (en) | 2004-01-30 | 2005-01-28 | Power transmission chain, manufacture method thereof and power transmission assembly |
US11/084,809 Continuation US20050283844A1 (en) | 2001-02-14 | 2005-03-21 | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
US11/446,560 Continuation-In-Part US7927587B2 (en) | 1999-08-05 | 2006-06-02 | MAPC administration for the treatment of lysosomal storage disorders |
US12/907,495 Continuation US10638734B2 (en) | 1999-08-05 | 2010-10-19 | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
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WO2002064748A8 WO2002064748A8 (en) | 2003-04-24 |
WO2002064748A3 true WO2002064748A3 (en) | 2003-08-21 |
WO2002064748A9 WO2002064748A9 (en) | 2006-03-30 |
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PCT/US2002/004652 WO2002064748A2 (en) | 1999-08-05 | 2002-02-14 | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
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US (3) | US7838289B2 (en) |
EP (2) | EP1367899A4 (en) |
JP (1) | JP2004529621A (en) |
CA (1) | CA2438501C (en) |
IL (4) | IL157332A0 (en) |
WO (1) | WO2002064748A2 (en) |
Families Citing this family (160)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040242520A1 (en) * | 1997-09-06 | 2004-12-02 | Mayo Foundation For Medical Education And Research, A Minnesota Corporation | Expression of immonogenic substances |
US20050158289A1 (en) * | 1999-07-07 | 2005-07-21 | Simmons Paul J. | Mesenchymal precursor cell and use thereof in the repair of bone defects and fractures in mammals |
AU2003901668A0 (en) * | 2003-03-28 | 2003-05-01 | Medvet Science Pty. Ltd. | Non-haemopoietic precursor cells |
US8062675B2 (en) * | 1999-07-07 | 2011-11-22 | Angioblast Systems, Inc. | Mesenchymal precursor cell |
US7670628B2 (en) * | 1999-07-07 | 2010-03-02 | Angioblast Systems, Inc. | Mesenchymal precursor cell |
AUPQ147799A0 (en) | 1999-07-07 | 1999-07-29 | Medvet Science Pty. Ltd. | Mesenchymal precursor cell |
US8609412B2 (en) | 1999-08-05 | 2013-12-17 | Regents Of The University Of Minnesota | Mapc generation of lung tissue |
US10638734B2 (en) | 2004-01-05 | 2020-05-05 | Abt Holding Company | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
US8147824B2 (en) * | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
WO2005113748A2 (en) * | 2004-04-21 | 2005-12-01 | Regents Of The University Of Minnesota | Mapc generation of lung tissue |
US8252280B1 (en) | 1999-08-05 | 2012-08-28 | Regents Of The University Of Minnesota | MAPC generation of muscle |
US7291597B2 (en) * | 2000-04-06 | 2007-11-06 | Franco Wayne P | Growth factor therapy mobilization of stem cells into the peripheral blood |
US7311905B2 (en) * | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
KR100915482B1 (en) | 2000-12-06 | 2009-09-03 | 하리리 로버트 제이 | Method of collecting placental stem cells |
NZ528035A (en) * | 2001-02-14 | 2005-07-29 | Robert J Hariri | Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells |
EP1367899A4 (en) | 2001-02-14 | 2004-07-28 | Leo T Furcht | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
EP1362095B1 (en) * | 2001-02-14 | 2015-05-27 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
DE10144326B4 (en) * | 2001-09-10 | 2005-09-22 | Siemens Ag | Method and system for monitoring a tire air pressure |
US9969980B2 (en) * | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
EP1471918B1 (en) | 2002-01-14 | 2017-07-19 | The Board Of Trustees Of The University Of Illinois | Use of modified pyrimidine compounds to promote stem cell migration and proliferation |
US20030228287A1 (en) * | 2002-06-07 | 2003-12-11 | Regents Of The University Of California | Maintenance of islet cells |
EP1563058A4 (en) * | 2002-07-12 | 2005-12-28 | Univ Singapore | Hemangioblast progenitor cells |
US20040052771A1 (en) * | 2002-07-12 | 2004-03-18 | Lim Sai Kiang | Hemangioblast progenitor cells |
US7422736B2 (en) | 2002-07-26 | 2008-09-09 | Food Industry Research And Development Institute | Somatic pluripotent cells |
CA2493363A1 (en) * | 2002-07-29 | 2004-02-05 | Asahi Kasei Kabushiki Kaisha | Stem cells for treating pancreatic damage |
JP4603883B2 (en) * | 2002-07-31 | 2010-12-22 | サントル・ナショナル・ドゥ・ラ・レシェルシュ・サイエンティフィーク−セ・エン・エール・エス− | Stem cells derived from adipose tissue and cells differentiated from the cells |
US9969977B2 (en) * | 2002-09-20 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
US7074561B2 (en) * | 2002-10-22 | 2006-07-11 | Biomerieux, Inc. | Isothermal amplification based assay for the detection and quantitation of alpha-fetoprotein mRNA |
WO2004087896A2 (en) * | 2003-03-31 | 2004-10-14 | Pfizer Products Inc. | Hepatocyte differentiation of stem cells |
DE10362002B4 (en) | 2003-06-23 | 2006-10-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Adult pluripotent stem cells |
AU2004253508A1 (en) * | 2003-06-25 | 2005-01-13 | Acell, Inc. | Conditioned matrix compositions for tissue restoration |
US9572840B2 (en) | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
US7875272B2 (en) | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
WO2005038012A2 (en) | 2003-06-27 | 2005-04-28 | Ethicon Incorporated | Cartilage and bone repair and regeneration using postpartum-derived cells |
US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
WO2005003317A2 (en) * | 2003-07-01 | 2005-01-13 | Regents Of The University Of Minnesota | Engineered blood vessels |
EP2450433A3 (en) | 2003-10-08 | 2012-08-08 | Vet-Stem Inc | Methods of preparing and using stem cell compositions and kits comprising the same |
GB0329449D0 (en) * | 2003-12-19 | 2004-01-28 | Omnicyte Ltd | Stem cells |
WO2005095588A1 (en) * | 2004-03-31 | 2005-10-13 | Kyoto University | Cortex glutamatergic neuron precursor providing cortex glutamatergic neuron and cortex glutamatergic neuron precursor alone in vivo |
CN101080486B (en) * | 2004-04-23 | 2012-05-16 | 佰欧益股份有限公司 | Multi-lineage progenitor cells |
US7622108B2 (en) * | 2004-04-23 | 2009-11-24 | Bioe, Inc. | Multi-lineage progenitor cells |
BRPI0511287A (en) | 2004-05-17 | 2007-12-04 | Univ Minnesota | use of umbilical cord blood stem cells to treat ischemic event |
US20080064034A1 (en) * | 2004-05-21 | 2008-03-13 | Fraunhofer-Gesellschaft Zur Förderung Der Angewand | Multi-Cellular Test Systems |
WO2006028723A1 (en) * | 2004-09-03 | 2006-03-16 | Moraga Biotechnology Inc. | Non-embryonic totipotent blastomer-like stem cells and methods therefor |
US20090029912A1 (en) * | 2004-09-24 | 2009-01-29 | Stan Gronthos | Method of enhancing proliferation and/or survival of mesenchymal precursor cells (mpc) |
JP2008514214A (en) * | 2004-09-29 | 2008-05-08 | セルアーティス アーベー | Method for generating hepatocyte-like cells from human blastocyst-derived stem cells (hBS) |
US20090130064A1 (en) * | 2004-10-27 | 2009-05-21 | Vera Rogiers | Differentiation of stem cells and stabilization of phenotypical properties of primary cells |
JP2008029201A (en) * | 2004-11-05 | 2008-02-14 | Hidechika Okada | Method for preparing stem cell and tissue remedy |
US7883535B2 (en) | 2004-11-09 | 2011-02-08 | Institut National D'optique | Device and method for transmitting multiple optically-encoded stimulation signals to multiple cell locations |
CA2589063C (en) | 2004-12-23 | 2016-08-09 | Ethicon Incorporated | Treatment of parkinson's disease and related disorders using postpartum derived cells |
WO2006086639A1 (en) | 2005-02-10 | 2006-08-17 | Regents Of The University Of Minnesota | Vascular/lymphatic endothelial cells |
CA2607218C (en) * | 2005-05-05 | 2016-08-23 | Regents Of The University Of Minnesota | Use of mapc or progeny therefrom to populate lymphohematopoietic tissues |
JP2009509911A (en) * | 2005-05-05 | 2009-03-12 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | Use of MAPCs or their progeny to establish lymphatic hematopoietic tissue |
CN101218341A (en) * | 2005-05-05 | 2008-07-09 | 明尼苏达大学董事会 | Use of NK cell inhibition to facilitate persistence of engrafted MHC-I negative cells |
ES2524996T3 (en) | 2005-06-16 | 2014-12-16 | Ramot At Tel Aviv University Ltd. | Isolated cells and populations that comprise them for the treatment of CNS diseases |
US20080194024A1 (en) * | 2005-07-29 | 2008-08-14 | Mays Robert W | Culture of Non-Embryonic Cells at High Cell Density |
EP1924606A4 (en) | 2005-08-25 | 2010-01-13 | Repair Technologies Inc | Devices, compositions and methods for the protection and repair of cells and tissues |
ES2452595T3 (en) | 2005-10-13 | 2014-04-02 | Anthrogenesis Corporation | Immunomodulation using placental stem cells |
US11000546B2 (en) * | 2005-11-09 | 2021-05-11 | Athersys, Inc. | Immunomodulatory properties of MAPCs and uses thereof |
US10117900B2 (en) * | 2005-11-09 | 2018-11-06 | Athersys, Inc. | MAPC treatment of brain injuries and diseases |
KR100697326B1 (en) * | 2005-12-02 | 2007-03-20 | 재단법인서울대학교산학협력재단 | Multipotent Adult Stem Cells Having an Ability of Oct4 Expression Derived from Umbilical Cord Blood and Method for Preparing the Same |
WO2007070870A1 (en) | 2005-12-16 | 2007-06-21 | Ethicon, Inc. | Compositions and methods for inhibiting adverse immune response in histocompatibility-mismatched transplantation |
US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
US8455250B2 (en) | 2005-12-29 | 2013-06-04 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
PL2471904T3 (en) | 2005-12-29 | 2019-08-30 | Celularity, Inc. | Placental stem cell populations |
WO2007087293A2 (en) * | 2006-01-23 | 2007-08-02 | Athersys, Inc. | Mapc therapeutics without adjunctive immunosuppressive treatment |
NZ570614A (en) | 2006-01-23 | 2012-07-27 | Athersys Inc | Multipotent adult progenitor cell treatment of brain injuries and diseases |
GEP20135796B (en) | 2006-03-07 | 2013-04-10 | Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation | |
US20070269411A1 (en) * | 2006-03-10 | 2007-11-22 | Wei Sun | Porous silicon materials and devices |
KR100871984B1 (en) | 2006-04-12 | 2008-12-05 | 주식회사 알앤엘바이오 | Multipotent Stem Cell Derived from Placenta Tissue and Cellular Therapeutic Agents Comprising the Same |
EP2019858B1 (en) * | 2006-04-17 | 2012-06-13 | BioE LLC | Differentiation of multi-lineage progenitor cells to respiratory epithelial cells |
US7989204B2 (en) * | 2006-04-28 | 2011-08-02 | Viacyte, Inc. | Hepatocyte lineage cells |
KR100792184B1 (en) * | 2006-05-12 | 2008-01-07 | 재단법인서울대학교산학협력재단 | Mutipotent Adult Stem Cell Derived from Canine Umbilical Cord Blood, Placenta and Canine Fetus Heart, Method for Preparing the Same and Cellular Therapeutics Containing the Same |
US20080050814A1 (en) * | 2006-06-05 | 2008-02-28 | Cryo-Cell International, Inc. | Procurement, isolation and cryopreservation of fetal placental cells |
WO2007146106A2 (en) * | 2006-06-05 | 2007-12-21 | Cryo- Cell International, Inc. | Procurement, isolation and cryopreservation of maternal placental cells |
ZA200810412B (en) * | 2006-06-09 | 2010-03-31 | Anthrogenesis Corp | Placental niche and use thereof to culture stem cells |
US7875453B2 (en) * | 2006-06-14 | 2011-01-25 | Bioe Llc | Differentiation of multi-lineage progenitor cells to hepatocytes |
US7993918B2 (en) * | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
KR100818213B1 (en) | 2006-09-22 | 2008-04-01 | 재단법인서울대학교산학협력재단 | Human Cord Blood Multipotent Stem Cell Having Enhanced Proliferation Ability With Osteoclast-based Niche-like Structure and Method for Preparing the Same |
KR100818214B1 (en) | 2006-09-29 | 2008-04-01 | 재단법인서울대학교산학협력재단 | Multipotent stem cell derived from amnion or decidua isolated from human term placenta and method for preparing the same |
WO2008060788A2 (en) | 2006-10-11 | 2008-05-22 | The General Hospital Corporation | Compositions, methods, and devices for treating liver disease |
CA2850793A1 (en) * | 2006-10-23 | 2008-05-02 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
US20100111905A1 (en) * | 2006-11-08 | 2010-05-06 | Aldagen,Inc. | Methods for improved engraftment following stem cell transplantation |
WO2008063675A2 (en) * | 2006-11-24 | 2008-05-29 | Regents Of The University Of Minnesota | Endodermal progenitor cells |
AU2008216749B2 (en) | 2007-02-12 | 2014-03-13 | Celularity Inc. | Treatment of inflammatory diseases using placental stem cells |
WO2008101100A2 (en) * | 2007-02-14 | 2008-08-21 | Indiana University Research And Technology Corporation | Composition for stimulating formation of vascular structures |
US8574567B2 (en) * | 2007-05-03 | 2013-11-05 | The Brigham And Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
WO2008137115A1 (en) | 2007-05-03 | 2008-11-13 | The Brigham And Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
TWM322542U (en) * | 2007-05-23 | 2007-11-21 | Universal Scient Ind Co Ltd | Testing machine |
WO2008156728A1 (en) * | 2007-06-15 | 2008-12-24 | Neuronyx, Inc. | Treatment of diseases and disorders using self-renewing colony forming cells cultured and expanded in vitro |
WO2008156659A1 (en) | 2007-06-18 | 2008-12-24 | Children's Hospital & Research Center At Oakland | Method of isolating stem and progenitor cells from placenta |
US20090029463A1 (en) * | 2007-07-25 | 2009-01-29 | Bioe, Inc. | Differentiation of Multi-Lineage Progenitor Cells to Chondrocytes |
EP2783692B1 (en) | 2007-09-28 | 2019-01-02 | Celularity, Inc. | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
WO2009061442A1 (en) * | 2007-11-06 | 2009-05-14 | Children's Medical Center Corporation | Method to produce induced pluripotent stem (ips) cells form non-embryonic human cells |
CA2712496C (en) | 2008-01-18 | 2021-01-12 | Wei-Shou Hu | Stem cell aggregates and methods for making and using |
US20090233993A1 (en) * | 2008-03-06 | 2009-09-17 | Burnham Institute For Medical Research | Compositions and methods for inhibiting gsk3 activity and uses thereof |
CA2723765A1 (en) * | 2008-05-08 | 2009-11-12 | Coretherapix Slu | Multipotent adult stem cell population |
CA2724839A1 (en) * | 2008-05-21 | 2009-11-26 | Bioe Llc | Differentiation of multi-lineage progenitor cells to pancreatic cells |
WO2009144718A1 (en) | 2008-05-28 | 2009-12-03 | Ramot At Tel Aviv University Ltd. | Mesenchymal stem cells for the treatment of cns diseases |
CN105796602A (en) | 2008-08-20 | 2016-07-27 | 人类起源公司 | Treatment of stroke using isolated placental cells |
MX2011001990A (en) | 2008-08-20 | 2011-03-29 | Anthrogenesis Corp | Improved cell composition and methods of making the same. |
CN102176919A (en) | 2008-08-22 | 2011-09-07 | 人类起源公司 | Methods and compositions for treatment of bone defects with placental cell populations |
GB0818725D0 (en) | 2008-10-13 | 2008-11-19 | Habib Nagy A | Pharmaceutical composition |
KR20110086176A (en) | 2008-11-19 | 2011-07-27 | 안트로제네시스 코포레이션 | Amnion derived adherent cells |
US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
PL2379088T3 (en) | 2008-12-19 | 2018-07-31 | DePuy Synthes Products, Inc. | Treatment of lung and pulmonary diseases and disorders |
US8771677B2 (en) | 2008-12-29 | 2014-07-08 | Vladimir B Serikov | Colony-forming unit cell of human chorion and method to obtain and use thereof |
KR101720961B1 (en) * | 2009-02-27 | 2017-03-29 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | Differentiation of pluripotent cells |
KR100950195B1 (en) * | 2009-03-20 | 2010-03-29 | 서울대학교산학협력단 | Method for isolation of umbilical cord blood derived-pluripotent stem cell expressing znf281 |
AU2010229651B2 (en) | 2009-03-26 | 2014-05-08 | Advanced Technologies And Regenerative Medicine, Llc | Human umbilical cord tissue cells as therapy for Alzheimer' s disease |
EP2419511B1 (en) | 2009-04-09 | 2018-01-17 | Sangamo Therapeutics, Inc. | Targeted integration into stem cells |
WO2010140464A1 (en) * | 2009-06-05 | 2010-12-09 | 国立大学法人 熊本大学 | Method for induction of cell differentiation |
WO2010144696A1 (en) | 2009-06-11 | 2010-12-16 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
MX338100B (en) * | 2009-07-09 | 2016-04-01 | Janssen Biotech Inc | Cardiac tissue-derived cells. |
SG10201404281YA (en) | 2009-07-21 | 2014-09-26 | Abt Holding Co | Use of stem cells to reduce leukocyte extravasation |
AU2010276201B2 (en) | 2009-07-21 | 2013-10-17 | Abt Holding Company | Use of stem cells to reduce leukocyte extravasation |
WO2011082339A2 (en) * | 2009-12-31 | 2011-07-07 | Cedars-Sinai Medical Center | Regeneration of, reestablishing function in and replacing microvasculature in organs and tissues |
ES2646750T3 (en) | 2010-01-26 | 2017-12-15 | Anthrogenesis Corporation | Treatment of bone-related cancers using placental stem cells |
AU2011220721B2 (en) | 2010-02-25 | 2015-02-05 | Abt Holding Company | Modulation of macrophage activation |
KR101900507B1 (en) | 2010-02-25 | 2018-09-19 | 에이비티 홀딩 컴퍼니 | Modulation of angiogenesis |
SI2556145T1 (en) | 2010-04-07 | 2017-01-31 | Anthrogenesis Corporation | Angiogenesis using placental stem cells |
KR20130092394A (en) | 2010-04-08 | 2013-08-20 | 안트로제네시스 코포레이션 | Treatment of sarcoidosis using placental stem cells |
SG10201503700WA (en) | 2010-05-12 | 2015-06-29 | Abt Holding Co | Modulation of splenocytes in cell therapy |
US9090878B2 (en) | 2010-06-17 | 2015-07-28 | Katholieke Universiteit Leuven | Methods for differentiating cells into hepatic stellate cells and hepatic sinusoidal endothelial cells, cells produced by the methods, and methods for using the cells |
RU2445106C1 (en) * | 2010-07-01 | 2012-03-20 | Закрытое Акционерное Общество "Фарм-Синтез" | Pharmaceutical composition for treating central and peripheral nervous system disorders of cardiovascular, traumatic, toxic, hypoxic and autoimmune genesis |
RU2428196C1 (en) * | 2010-07-01 | 2011-09-10 | Закрытое Акционерное Общество "Фарм-Синтез" | Method for preparing biologically active complex and biologically active protein-polypeptide complex |
NZ605505A (en) | 2010-07-13 | 2015-02-27 | Anthrogenesis Corp | Methods of generating natural killer cells |
US8609406B2 (en) | 2010-08-24 | 2013-12-17 | Regents Of The University Of Minnesota | Non-static suspension culture of cell aggregates |
EP2625264B1 (en) | 2010-10-08 | 2022-12-07 | Terumo BCT, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
US8574899B2 (en) | 2010-12-22 | 2013-11-05 | Vladimir B Serikov | Methods for augmentation collection of placental hematopoietic stem cells and uses thereof |
AR093183A1 (en) | 2010-12-31 | 2015-05-27 | Anthrogenesis Corp | INCREASE IN THE POWER OF PLACENTA MOTHER CELLS USING MODULATING RNA MOLECULES |
TWI586805B (en) * | 2011-01-12 | 2017-06-11 | 城戶常雄 | Culture method to obtain and maintain a pure or enriched population of mammalian neural stem cells and/or neural progenitor cells that are prone to differentiate into oligodendrocyte-lineage cells in vitro |
WO2012135729A2 (en) | 2011-03-30 | 2012-10-04 | Board Of Regents Of The University Of Texas System | Methods and compositions for targeting adipose cells in mammals |
EP3443968A1 (en) | 2011-06-01 | 2019-02-20 | Celularity, Inc. | Treatment of pain using placental stem cells |
DK2718416T3 (en) | 2011-06-06 | 2020-02-24 | ReGenesys BVBA | Expansion of stem cells in hollow fiber bioreactors |
US9925221B2 (en) | 2011-09-09 | 2018-03-27 | Celularity, Inc. | Treatment of amyotrophic lateral sclerosis using placental stem cells |
KR101981450B1 (en) | 2011-12-23 | 2019-08-28 | 디퍼이 신테스 프로덕츠, 인코포레이티드 | Detection of human umbilical cord tissue-derived cells |
US20150064141A1 (en) | 2012-04-05 | 2015-03-05 | The Regents Of The University Of California | Regenerative sera cells and mesenchymal stem cells |
AU2014215458A1 (en) | 2013-02-05 | 2015-08-13 | Anthrogenesis Corporation | Natural killer cells from placenta |
HUE052516T2 (en) | 2013-04-12 | 2021-05-28 | Houston Methodist Hospital | Improving organs for transplantation |
AU2014266935B2 (en) | 2013-04-30 | 2020-06-11 | Katholieke Universiteit Leuven | Cell therapy for myelodysplastic syndromes |
WO2015073913A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
US20160090569A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled Feed |
EP3307874A4 (en) * | 2015-06-12 | 2019-04-24 | Agency For Science, Technology And Research | Derivation of hepatic stem cells and mature liver cell types and uses thereof |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
WO2017062401A1 (en) | 2015-10-05 | 2017-04-13 | ORIG3N Inc. | Diagnosis and treatment of parkinson's disease based on identification and amelioration of liver dysfunction |
AU2016387339B2 (en) | 2016-01-21 | 2022-11-17 | Abt Holding Company | Stem cells for wound healing |
EP3464565A4 (en) | 2016-05-25 | 2020-01-01 | Terumo BCT, Inc. | Cell expansion |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
CN114176043B (en) * | 2016-06-14 | 2024-04-23 | 明尼苏达大学董事会 | Genetically modified cells, tissues and organs for the treatment of diseases |
US11629332B2 (en) | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
AU2019377532A1 (en) * | 2018-11-09 | 2021-06-10 | Figene, Llc | Regenerative abscopal effects |
US20200246390A1 (en) | 2019-02-01 | 2020-08-06 | Abt Holding Company | Multipotent adult projenitor cells for treatment of ich |
US11697799B2 (en) * | 2019-04-15 | 2023-07-11 | Ossium Health, Inc. | System and method for extraction and cryopreservation of bone marrow |
CA3175071A1 (en) | 2020-03-11 | 2021-09-16 | Bit Bio Limited | Method of generating hepatic cells |
Family Cites Families (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4714680B1 (en) | 1984-02-06 | 1995-06-27 | Univ Johns Hopkins | Human stem cells |
US5130144B1 (en) | 1984-02-06 | 1995-08-15 | Univ Johns Hopkins | Human stem cells and monoclonal antibodies |
US4965204A (en) | 1984-02-06 | 1990-10-23 | The Johns Hopkins University | Human stem cells and monoclonal antibodies |
US5087570A (en) * | 1988-05-10 | 1992-02-11 | Weissman Irving L | Homogeneous mammalian hematopoietic stem cell composition |
US5635386A (en) | 1989-06-15 | 1997-06-03 | The Regents Of The University Of Michigan | Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture |
US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
US5197985A (en) * | 1990-11-16 | 1993-03-30 | Caplan Arnold I | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells |
US5733542A (en) * | 1990-11-16 | 1998-03-31 | Haynesworth; Stephen E. | Enhancing bone marrow engraftment using MSCS |
AU4543193A (en) | 1992-06-22 | 1994-01-24 | Henry E. Young | Scar inhibitory factor and use thereof |
US5589376A (en) | 1992-07-27 | 1996-12-31 | California Institute Of Technology | Mammalian neural crest stem cells |
US5693482A (en) | 1992-07-27 | 1997-12-02 | California Institute Of Technology | Neural chest stem cell assay |
US5654183A (en) | 1992-07-27 | 1997-08-05 | California Institute Of Technology | Genetically engineered mammalian neural crest stem cells |
GB9308271D0 (en) | 1993-04-21 | 1993-06-02 | Univ Edinburgh | Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method |
NZ314644A (en) | 1993-05-24 | 2000-11-24 | Immunex Corp | Use of flt3-ligands as a growth stimulator of stem cells in the transplantation of tissue |
WO1995003062A1 (en) * | 1993-07-21 | 1995-02-02 | Cellpro, Incorporated | Methods and compositions for preventing immune rejection of solid organ grafts |
WO1995010599A1 (en) | 1993-10-15 | 1995-04-20 | The University Of Melbourne | Embryonic stem cell-like cells |
US5602301A (en) | 1993-11-16 | 1997-02-11 | Indiana University Foundation | Non-human mammal having a graft and methods of delivering protein to myocardial tissue |
US6015671A (en) | 1995-06-07 | 2000-01-18 | Indiana University Foundation | Myocardial grafts and cellular compositions |
US5486659A (en) * | 1994-03-08 | 1996-01-23 | Rosenbush; Stuart W. | Stethoscope protection device and method for using same |
DE4441327C1 (en) | 1994-11-22 | 1995-11-09 | Inst Pflanzengenetik & Kultur | Embryonic heart muscle cells, their production and their use |
US5648248A (en) | 1994-12-30 | 1997-07-15 | Boehringer Ingelheim International Gmbh | Methods for producing differentiated cells from immature hematopoietic cells |
US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
US5736396A (en) * | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
GB9502022D0 (en) | 1995-02-02 | 1995-03-22 | Abuljadayel Ilham M S | A method for preparing lymphohaematopoietic progenitor cells |
US5906934A (en) | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
US6653134B2 (en) | 1995-03-28 | 2003-11-25 | Cp Hahnemann University | Isolated stromal cells for use in the treatment of diseases of the central nervous system |
US6306575B1 (en) | 1995-06-16 | 2001-10-23 | Stemcell Technologies, Inc. | Methods for preparing enriched human hematopoietic cell preparations |
CA2191655C (en) | 1995-12-01 | 2010-01-12 | Terry E. Thomas | Novel antibody compositions for preparing enriched human hematopoietic and tumor cell preparations |
US20010012513A1 (en) | 1996-08-19 | 2001-08-09 | University Of Massachusetts | Embryonic or stem-like cell lines produced by cross species nuclear transplantation |
US6787355B1 (en) | 1996-08-26 | 2004-09-07 | Mcgill University | Multipotent neural stem cells from peripheral tissues and uses thereof |
US6271436B1 (en) | 1996-10-11 | 2001-08-07 | The Texas A & M University System | Cells and methods for the generation of transgenic pigs |
US6090622A (en) | 1997-03-31 | 2000-07-18 | The Johns Hopkins School Of Medicine | Human embryonic pluripotent germ cells |
US5968829A (en) | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
AU9582398A (en) | 1997-09-25 | 1999-04-12 | Cytomatrix, Llc | Methods and devices for the long-term culture of hematopoietic progenitor cells |
US6093531A (en) | 1997-09-29 | 2000-07-25 | Neurospheres Holdings Ltd. | Generation of hematopoietic cells from multipotent neural stem cells |
WO1999027076A1 (en) | 1997-11-25 | 1999-06-03 | Arc Genomic Research | Pluripotent embryonic stem cells and methods of obtaining them |
CA2315265A1 (en) | 1998-01-12 | 1999-07-15 | Cold Spring Harbor Laboratory | Extension of cellular lifespan, methods and reagents |
WO2001051611A1 (en) | 2000-01-14 | 2001-07-19 | Bresagen Limited | Cell production |
NZ507103A (en) | 1998-04-09 | 2002-10-25 | Bresagen Ltd | Cell differentiation/proliferation and maintenance factor and uses thereof |
US6225119B1 (en) | 1998-05-22 | 2001-05-01 | Osiris Therapeutics, Inc. | Production of megakaryocytes by the use of human mesenchymal stem cells |
DE19833476B4 (en) | 1998-07-24 | 2005-08-25 | Huss, Ralf, Dr. | Genetically modified CD34 negatives, adherently growing hematopoietic stem cells and their use in gene therapy |
EP1117764A1 (en) | 1998-09-01 | 2001-07-25 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells with compatible histocompatibility genes |
AU2707100A (en) | 1998-11-30 | 2000-06-19 | Ivf Sciences Colorado, Inc. | System and sequential culture media for in vitro fertilization |
US6777231B1 (en) | 1999-03-10 | 2004-08-17 | The Regents Of The University Of California | Adipose-derived stem cells and lattices |
US20050169896A1 (en) | 1999-05-14 | 2005-08-04 | Henry Ford Health System | Bone marrow transplantation for treatment of stroke |
AUPQ147799A0 (en) | 1999-07-07 | 1999-07-29 | Medvet Science Pty. Ltd. | Mesenchymal precursor cell |
ATE408667T1 (en) | 1999-07-20 | 2008-10-15 | Univ Southern California | IDENTIFICATION OF PLURIPOTENT PREMESENCHYMAL, PREHEMOTOPOIETIC PRONECTOR CELLS |
CA2378140A1 (en) | 1999-07-29 | 2001-02-08 | Steven Baranowitz | Methods for transdifferentiation of body tissues |
US8609412B2 (en) * | 1999-08-05 | 2013-12-17 | Regents Of The University Of Minnesota | Mapc generation of lung tissue |
US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
US8075881B2 (en) | 1999-08-05 | 2011-12-13 | Regents Of The University Of Minnesota | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
US7927587B2 (en) | 1999-08-05 | 2011-04-19 | Regents Of The University Of Minnesota | MAPC administration for the treatment of lysosomal storage disorders |
IL147990A0 (en) * | 1999-08-05 | 2002-09-12 | Mcl Llc | Multipotent adult stem cells and methods for isolation |
US8147824B2 (en) | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
EP1218487A2 (en) | 1999-09-23 | 2002-07-03 | Cell Science Therapeutics | Methods and devices for obtaining non-hematopoietic lineage cells from hematopoietic progenitor cells |
AU7611500A (en) | 1999-09-24 | 2001-04-24 | Abt Holding Company | Pluripotent embryonic-like stem cells, compositions, methods and uses thereof |
CA2385628A1 (en) | 1999-09-27 | 2001-04-05 | Ammon B. Peck | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
IL149043A0 (en) | 1999-10-15 | 2002-11-10 | Advanced Cell Tech Inc | Methods of producing differentiated progenitor cells and lineage-defective embryonic stem cells |
US6280718B1 (en) | 1999-11-08 | 2001-08-28 | Wisconsin Alumni Reasearch Foundation | Hematopoietic differentiation of human pluripotent embryonic stem cells |
CN100475953C (en) | 1999-12-06 | 2009-04-08 | 通用医疗公司 | Pancreatic stem cells |
US6602711B1 (en) | 2000-02-21 | 2003-08-05 | Wisconsin Alumni Research Foundation | Method of making embryoid bodies from primate embryonic stem cells |
DE60132429T2 (en) | 2000-02-26 | 2009-01-08 | Artecel, Inc. | PLURIPOTENTS FROM FAT-FROZEN-GENERIC STROMA CELLS GENERATED STRAIN CELLS AND THEIR USE |
US7005252B1 (en) | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
WO2001068815A1 (en) | 2000-03-14 | 2001-09-20 | Es Cell International Pte Ltd | Embryonic stem cells and neural progenitor cells derived therefrom |
EP1176189A1 (en) | 2000-07-21 | 2002-01-30 | Fornix Biosciences N.V. | Stem cell-like cells |
AU2001284695A1 (en) | 2000-07-31 | 2002-02-13 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
GB0026252D0 (en) | 2000-10-26 | 2000-12-13 | Univ Edinburgh | Pluripotential stem cells |
US7560280B2 (en) | 2000-11-03 | 2009-07-14 | Kourion Therapeutics Gmbh | Human cord blood derived unrestricted somatic stem cells (USSC) |
KR100915482B1 (en) | 2000-12-06 | 2009-09-03 | 하리리 로버트 제이 | Method of collecting placental stem cells |
US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
EP1367899A4 (en) | 2001-02-14 | 2004-07-28 | Leo T Furcht | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
EP1362095B1 (en) | 2001-02-14 | 2015-05-27 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
US7056738B2 (en) | 2001-03-23 | 2006-06-06 | Tulane University | Early stage multipotential stem cells in colonies of bone marrow stromal cells |
KR100449141B1 (en) | 2001-04-19 | 2004-09-21 | (주)라이프코드 | Method for differentiating a mesenchymal stem cell into neural cells |
US20030003090A1 (en) | 2001-05-31 | 2003-01-02 | Prockop Darwin J. | Directed in vitro differentiation of marrow stromal cells into neural cell progenitors |
US9969980B2 (en) | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
AU2003298016A1 (en) | 2002-11-27 | 2004-06-23 | Regents Of The University Of Minnesota | Homologous recombination in multipotent adult progenitor cells |
US20040235165A1 (en) | 2003-05-19 | 2004-11-25 | Darwin Prockop | In vitro differentiation of adult stem cells |
WO2005003317A2 (en) | 2003-07-01 | 2005-01-13 | Regents Of The University Of Minnesota | Engineered blood vessels |
WO2005003320A2 (en) | 2003-07-02 | 2005-01-13 | Regents Of The University Of Minnesota | Neuronal differentiation of stem cells |
AU2004269409A1 (en) | 2003-08-29 | 2005-03-10 | Regents Of The University Of Minnesota | Kidney derived stem cells and methods for their isolation, differentiation and use |
-
2002
- 2002-02-14 EP EP02718998A patent/EP1367899A4/en not_active Withdrawn
- 2002-02-14 US US10/467,963 patent/US7838289B2/en active Active
- 2002-02-14 JP JP2002565063A patent/JP2004529621A/en not_active Withdrawn
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- 2002-02-14 WO PCT/US2002/004652 patent/WO2002064748A2/en active Application Filing
-
2003
- 2003-08-11 IL IL157332A patent/IL157332A/en active IP Right Grant
- 2003-08-11 IL IL214623A patent/IL214623A/en active IP Right Grant
-
2005
- 2005-03-21 US US11/084,809 patent/US20050283844A1/en not_active Abandoned
-
2011
- 2011-03-07 US US13/042,205 patent/US20110177595A1/en not_active Abandoned
- 2011-08-11 IL IL214623A patent/IL214623A0/en unknown
Non-Patent Citations (10)
Title |
---|
CARGILL M. ET AL.: "Characterization of single-nucleotide polymorphisms in coding regions of human genes", NATURE GENETICS, vol. 22, July 1999 (1999-07-01), pages 231 - 238, XP002121300 * |
GEIGER H. ET AL.: "Globin gene expression is reprogrammed in chimeras generated by injecting adult hematopoietic stem cells into mouse blastocysts", CELL, vol. 93, no. 6, 12 June 1998 (1998-06-12), pages 1055 - 1065, XP000941662 * |
GEISSLER E.K. ET AL.: "Effective use of donor MHC class I gene therapy in organ transplantation prevention of antibody-mediated hyperacute heart allograft rejection in highly sensitized rat recipients", HUMAN GENE THERAPY, vol. 11, no. 3, 2000, pages 459 - 469, XP002954855 * |
GRIGORIADOU K. ET AL.: "MHC class in molecules alone control NK-mediated bone marrow graft rejection", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 29, no. 11, November 1999 (1999-11-01), pages 3683 - 3690, XP002954854 * |
GULCHER J. ET AL.: "Population genetics: laying the groundwork for genetic disease modeling and targeting", CLINICAL CHEMICAL LABORATORY MEDICINE, vol. 36, no. 8, 1998, pages 523 - 527, XP002941805 * |
HUILIN Q. ET AL.: "Identification of genes responsible for bone differentiation from human bone marrow derived multipotent adult stem cells (MASC)", BLOOD, vol. 96, no. 11, PART 1, 16 November 2000 (2000-11-16), pages 70A - 71A, ABS. 298, XP002955582 * |
KEENE C.D. ET AL.: "Phenotypic expression of transplanted human bone marrow-derived multipotent adult stem cells into the rat CNS", EXPERIMENTAL NEUROLOGY, vol. 164, no. 2, August 2000 (2000-08-01), pages 465, XP002954852 * |
KUZNETSOV S.A. ET AL.: "Factors required for bone marrow stromal fibroblast colony formation in vitro", BRITISH JOURNAL OF HEMATOLOGY, vol. 97, no. 3, June 1997 (1997-06-01), pages 561 - 570, XP002954851 * |
MARMUR R. ET AL.: "Isolation and developmental characterization of cerebral cortical multipotent progenitors", DEVELOPMENTAL BIOLOGY, vol. 204, no. 2, 1998, pages 577 - 591, XP002954853 * |
REYES M. ET AL.: "Characterization of multipotent adult progenitor cells, a subpopulation of mesenchymal stem cells", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 938, 2001, pages 231 - 235, XP002954850 * |
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US20110177595A1 (en) | 2011-07-21 |
JP2004529621A (en) | 2004-09-30 |
EP1491093A2 (en) | 2004-12-29 |
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CA2438501C (en) | 2014-09-16 |
US20050283844A1 (en) | 2005-12-22 |
WO2002064748A2 (en) | 2002-08-22 |
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EP1367899A4 (en) | 2004-07-28 |
WO2002064748A8 (en) | 2003-04-24 |
IL157332A0 (en) | 2004-02-19 |
EP1491093B1 (en) | 2013-07-31 |
IL214623A (en) | 2012-10-31 |
IL214623A0 (en) | 2011-09-27 |
US7838289B2 (en) | 2010-11-23 |
CA2438501A1 (en) | 2002-08-22 |
IL157332A (en) | 2011-11-30 |
EP1367899A2 (en) | 2003-12-10 |
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