WO2002061075A1 - Novel g protein-coupled receptor protein and dna thereof - Google Patents

Novel g protein-coupled receptor protein and dna thereof Download PDF

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Publication number
WO2002061075A1
WO2002061075A1 PCT/JP2002/000773 JP0200773W WO02061075A1 WO 2002061075 A1 WO2002061075 A1 WO 2002061075A1 JP 0200773 W JP0200773 W JP 0200773W WO 02061075 A1 WO02061075 A1 WO 02061075A1
Authority
WO
WIPO (PCT)
Prior art keywords
protein
ligand
screening
novel
dna
Prior art date
Application number
PCT/JP2002/000773
Other languages
French (fr)
Japanese (ja)
Inventor
Kenichi Horikoshi
Yoshio Taniyama
Yasushi Shintani
Nobuyuki Miyajima
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Publication of WO2002061075A1 publication Critical patent/WO2002061075A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

It is intended to provide a novel protein which is useful in, for example, screening an agonist/an antagonist. More particularly speaking, a protein originating in human beings or its salt, a DNA encoding this protein, a method of determining a ligand to this protein, a method/a kit for screening a compound capable of altering the binding properties of the ligand to the protein, a compound obtained by the screening or its salt, etc. are provided. The above-described protein originating in human beings and the DNA encoding the same are usable in: (1) determining a ligand to the above protein; (2) preventives and/or remedies for diseases relating to the hypofunction of the above protein; (3) screening a compound (an agonist, an antagonist, etc.) capable of altering the binding properties of the above protein to the ligand; and the like.
PCT/JP2002/000773 2001-02-01 2002-01-31 Novel g protein-coupled receptor protein and dna thereof WO2002061075A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2001025037 2001-02-01
JP2001-25037 2001-02-01
JP2001102559 2001-03-30
JP2001-102559 2001-03-30
JP2001-105435 2001-04-04
JP2001105435 2001-04-04

Publications (1)

Publication Number Publication Date
WO2002061075A1 true WO2002061075A1 (en) 2002-08-08

Family

ID=27345879

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/000773 WO2002061075A1 (en) 2001-02-01 2002-01-31 Novel g protein-coupled receptor protein and dna thereof

Country Status (1)

Country Link
WO (1) WO2002061075A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002101043A2 (en) * 2001-06-08 2002-12-19 Bayer Aktiengesellschaft Regulation of human ta4 receptor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6117900A (en) * 1999-09-27 2000-09-12 Asta Medica Aktiengesellschaft Use of retigabine for the treatment of neuropathic pain
WO2001036473A2 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Human g protein-coupled receptors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6117900A (en) * 1999-09-27 2000-09-12 Asta Medica Aktiengesellschaft Use of retigabine for the treatment of neuropathic pain
WO2001036473A2 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Human g protein-coupled receptors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BETH BOROWSKY ET AL.: "Trace amines: Identification of a family of mammalian G protein-coupled receptors", PROC. NATL. ACAD. SCI. USA, vol. 98, no. 16, June 2001 (2001-06-01), pages 8966 - 8971, XP002185201 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002101043A2 (en) * 2001-06-08 2002-12-19 Bayer Aktiengesellschaft Regulation of human ta4 receptor
WO2002101043A3 (en) * 2001-06-08 2003-08-28 Bayer Ag Regulation of human ta4 receptor

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