WO2003008445A1 - Novel g protein-coupled receptor protein and dna thereof - Google Patents

Novel g protein-coupled receptor protein and dna thereof Download PDF

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Publication number
WO2003008445A1
WO2003008445A1 PCT/JP2002/007306 JP0207306W WO03008445A1 WO 2003008445 A1 WO2003008445 A1 WO 2003008445A1 JP 0207306 W JP0207306 W JP 0207306W WO 03008445 A1 WO03008445 A1 WO 03008445A1
Authority
WO
WIPO (PCT)
Prior art keywords
protein
dna
novel
coupled receptor
ligand
Prior art date
Application number
PCT/JP2002/007306
Other languages
French (fr)
Japanese (ja)
Inventor
Shoichi Okubo
Yasushi Shintani
Nobuyuki Miyajima
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Publication of WO2003008445A1 publication Critical patent/WO2003008445A1/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

A mouse-origin protein or a DNA encoding the same is useful in: (1) determining a ligand to this protein; (2) preventives and/or remedies for diseases relating to hypofunction of the protein; and (3) screening a compound (an agonist, an antagonist, etc.) capable of changing the binding properties of the protein to a ligand.
PCT/JP2002/007306 2001-07-19 2002-07-18 Novel g protein-coupled receptor protein and dna thereof WO2003008445A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001220064 2001-07-19
JP2001-220064 2001-07-19

Publications (1)

Publication Number Publication Date
WO2003008445A1 true WO2003008445A1 (en) 2003-01-30

Family

ID=19053946

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/007306 WO2003008445A1 (en) 2001-07-19 2002-07-18 Novel g protein-coupled receptor protein and dna thereof

Country Status (1)

Country Link
WO (1) WO2003008445A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001044439A2 (en) * 1999-12-17 2001-06-21 Astrazeneca Ab Glucocorticoid induced receptor (hgir,rp-23) ligand screening
WO2002003793A2 (en) * 2000-07-10 2002-01-17 Deltagen, Inc. Transgenic mice containing targeted gene disruptions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001044439A2 (en) * 1999-12-17 2001-06-21 Astrazeneca Ab Glucocorticoid induced receptor (hgir,rp-23) ligand screening
WO2002003793A2 (en) * 2000-07-10 2002-01-17 Deltagen, Inc. Transgenic mice containing targeted gene disruptions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PARKER R. ET AL.: "Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6", BIOCHIM. BIOPHYS. ACTA, vol. 1491, no. 1-3, 25 April 2000 (2000-04-25), pages 369 - 375, XP004275650 *

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