WO2002060905A2 - Procede pour preparer des intermediaires d'inhibiteurs de la protease du vih - Google Patents

Procede pour preparer des intermediaires d'inhibiteurs de la protease du vih Download PDF

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Publication number
WO2002060905A2
WO2002060905A2 PCT/US2001/046116 US0146116W WO02060905A2 WO 2002060905 A2 WO2002060905 A2 WO 2002060905A2 US 0146116 W US0146116 W US 0146116W WO 02060905 A2 WO02060905 A2 WO 02060905A2
Authority
WO
WIPO (PCT)
Prior art keywords
furan
propynyloxy
group
6alkyl
hydrogen
Prior art date
Application number
PCT/US2001/046116
Other languages
English (en)
Inventor
Roman Davis
Thomas Clairborne Lovelace
Original Assignee
Glaxo Group Ltd
Roman Davis
Thomas Clairborne Lovelace
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Roman Davis, Thomas Clairborne Lovelace filed Critical Glaxo Group Ltd
Publication of WO2002060905A2 publication Critical patent/WO2002060905A2/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention concerne un procédé pour effectuer des réactions de cyclisation intramoléculaire à l'aide de la lumière, sans initiateurs de radicaux, pour produire des composés polycycliques utiles.
PCT/US2001/046116 2000-10-24 2001-10-22 Procede pour preparer des intermediaires d'inhibiteurs de la protease du vih WO2002060905A2 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24282200P 2000-10-24 2000-10-24

Publications (1)

Publication Number Publication Date
WO2002060905A2 true WO2002060905A2 (fr) 2002-08-08

Family

ID=22916319

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2001/046116 WO2002060905A2 (fr) 2000-10-24 2001-10-22 Procede pour preparer des intermediaires d'inhibiteurs de la protease du vih
PCT/US2001/051428 WO2002067239A2 (fr) 2000-10-24 2001-10-22 Methode de preparation d'intermediaires d'inhibiteurs de protease vih

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2001/051428 WO2002067239A2 (fr) 2000-10-24 2001-10-22 Methode de preparation d'intermediaires d'inhibiteurs de protease vih

Country Status (4)

Country Link
EP (1) EP1404680A2 (fr)
JP (1) JP2004519473A (fr)
AU (1) AU2002255473A1 (fr)
WO (2) WO2002060905A2 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004002975A1 (fr) * 2002-06-27 2004-01-08 Smithkline Beecham Corporation PREPARATION DE STEREOISOMERES DE (3ALPHA, 3ALPHA/BETA, 6ALPHA/BETA) HEXAHYDROFURO[2,3-b]FURAN-3-OL
US8153829B2 (en) 2006-11-09 2012-04-10 Janssen Pharmaceutica N.V. Methods for the preparation of hexahydrofuro[2,3-B]furan-3-ol
CN102516259A (zh) * 2006-03-29 2012-06-27 吉里德科学公司 制备hiv蛋白酶抑制剂的方法
CN103864813A (zh) * 2012-12-18 2014-06-18 上海迪赛诺化学制药有限公司 一种合成六氢呋喃并[2,3-b]呋喃-3-醇及其对映体的方法
CN107607635A (zh) * 2017-08-15 2018-01-19 东北制药集团股份有限公司 一种采用顶空气相色谱检测左磷右胺盐中丙炔醇含量的方法
US11827627B2 (en) 2021-06-04 2023-11-28 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels
US11834441B2 (en) 2019-12-06 2023-12-05 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofurans as modulators of sodium channels

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004002975A1 (fr) * 2002-06-27 2004-01-08 Smithkline Beecham Corporation PREPARATION DE STEREOISOMERES DE (3ALPHA, 3ALPHA/BETA, 6ALPHA/BETA) HEXAHYDROFURO[2,3-b]FURAN-3-OL
CN102516259A (zh) * 2006-03-29 2012-06-27 吉里德科学公司 制备hiv蛋白酶抑制剂的方法
CN102516259B (zh) * 2006-03-29 2014-12-10 吉里德科学公司 制备hiv蛋白酶抑制剂的方法
US8153829B2 (en) 2006-11-09 2012-04-10 Janssen Pharmaceutica N.V. Methods for the preparation of hexahydrofuro[2,3-B]furan-3-ol
CN103864813A (zh) * 2012-12-18 2014-06-18 上海迪赛诺化学制药有限公司 一种合成六氢呋喃并[2,3-b]呋喃-3-醇及其对映体的方法
CN107607635A (zh) * 2017-08-15 2018-01-19 东北制药集团股份有限公司 一种采用顶空气相色谱检测左磷右胺盐中丙炔醇含量的方法
CN107607635B (zh) * 2017-08-15 2020-07-31 东北制药集团股份有限公司 一种采用顶空气相色谱检测左磷右胺盐中丙炔醇含量的方法
US11834441B2 (en) 2019-12-06 2023-12-05 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofurans as modulators of sodium channels
US11919887B2 (en) 2019-12-06 2024-03-05 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofurans as modulators of sodium channels
US11827627B2 (en) 2021-06-04 2023-11-28 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels

Also Published As

Publication number Publication date
JP2004519473A (ja) 2004-07-02
EP1404680A2 (fr) 2004-04-07
WO2002067239A2 (fr) 2002-08-29
AU2002255473A1 (en) 2002-09-04
WO2002067239A3 (fr) 2004-01-08

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