WO2002051855A3 - Motilide compounds - Google Patents

Motilide compounds Download PDF

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Publication number
WO2002051855A3
WO2002051855A3 PCT/US2001/043963 US0143963W WO02051855A3 WO 2002051855 A3 WO2002051855 A3 WO 2002051855A3 US 0143963 W US0143963 W US 0143963W WO 02051855 A3 WO02051855 A3 WO 02051855A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
motilide
motilide compounds
formulas
treatment
Prior art date
Application number
PCT/US2001/043963
Other languages
French (fr)
Other versions
WO2002051855A2 (en
Inventor
Daniel Santi
Zong-Qiang Tian
Brian Metcalf
Gary Ashley
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Priority to EP01995209A priority Critical patent/EP1337540A2/en
Priority to AU2002225724A priority patent/AU2002225724A1/en
Priority to JP2002552948A priority patent/JP2004522726A/en
Priority to CA002429709A priority patent/CA2429709A1/en
Publication of WO2002051855A2 publication Critical patent/WO2002051855A2/en
Publication of WO2002051855A3 publication Critical patent/WO2002051855A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention provides novel macrolide compounds of the formulas for the treatment of gastrointestinal motility disorders.
PCT/US2001/043963 2000-12-01 2001-11-21 Motilide compounds WO2002051855A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01995209A EP1337540A2 (en) 2000-12-01 2001-11-21 Motilide compounds
AU2002225724A AU2002225724A1 (en) 2000-12-01 2001-11-21 Motilide compounds
JP2002552948A JP2004522726A (en) 2000-12-01 2001-11-21 Motilide compounds
CA002429709A CA2429709A1 (en) 2000-12-01 2001-11-21 Motilide compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25064000P 2000-12-01 2000-12-01
US60/250,640 2000-12-01
US26936201P 2001-02-15 2001-02-15
US60/269,362 2001-02-15

Publications (2)

Publication Number Publication Date
WO2002051855A2 WO2002051855A2 (en) 2002-07-04
WO2002051855A3 true WO2002051855A3 (en) 2002-10-31

Family

ID=26941026

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/043963 WO2002051855A2 (en) 2000-12-01 2001-11-21 Motilide compounds

Country Status (5)

Country Link
EP (1) EP1337540A2 (en)
JP (1) JP2004522726A (en)
AU (1) AU2002225724A1 (en)
CA (1) CA2429709A1 (en)
WO (1) WO2002051855A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003273254B2 (en) * 2002-08-29 2008-10-30 Bristol-Myers Squibb Company Motilide compounds
AR043050A1 (en) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc BIFunctional HETEROCICLICAL COMPOUNDS AND METHODS TO PREPARE AND USE THE SAME
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
JP4737495B2 (en) * 2004-01-14 2011-08-03 塩野義製薬株式会社 Erythromycin derivative
US8202843B2 (en) * 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
CN108101948A (en) * 2004-02-27 2018-06-01 瑞伯-X医药品有限公司 Macrocyclic compound and its making and use method
WO2007025089A2 (en) 2005-08-24 2007-03-01 Rib-X Pharmaceutical, Inc. Triazole compounds and methods of making and using the same
ES2638427T3 (en) * 2005-08-24 2017-10-20 Melinta Therapeutics, Inc. Triazole compounds and preparation and use procedures
AU2006300215B2 (en) * 2005-10-14 2012-06-21 Aphoenix, Inc. Novel dihydropseudoerythromycin derivatives
CA2662897C (en) 2006-09-11 2017-11-07 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders
WO2008106204A1 (en) * 2007-02-28 2008-09-04 Rib-X-Pharmaceuticals, Inc. Macrolide compounds and methods of making and using the same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018134A1 (en) * 1991-04-09 1992-10-29 Abbott Laboratories Macrocyclic lactam prokinetic agents
JPH08231580A (en) * 1994-12-27 1996-09-10 Chugai Pharmaceut Co Ltd Erythromycin derivative
WO2000062783A2 (en) * 1999-04-16 2000-10-26 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018134A1 (en) * 1991-04-09 1992-10-29 Abbott Laboratories Macrocyclic lactam prokinetic agents
JPH08231580A (en) * 1994-12-27 1996-09-10 Chugai Pharmaceut Co Ltd Erythromycin derivative
WO2000062783A2 (en) * 1999-04-16 2000-10-26 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FAGHIH R ET AL: "Preparation of 9-deoxo-4-deoxy-6,9-epoxyerythromycin lactams motilactides: potent and orally active prokinetic agents", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 8, no. 7, 7 April 1998 (1998-04-07), pages 805 - 810, XP004136969, ISSN: 0960-894X *
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 01 31 January 1997 (1997-01-31) *

Also Published As

Publication number Publication date
AU2002225724A1 (en) 2002-07-08
WO2002051855A2 (en) 2002-07-04
CA2429709A1 (en) 2002-07-04
JP2004522726A (en) 2004-07-29
EP1337540A2 (en) 2003-08-27

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