JP4737495B2 - Erythromycin derivative - Google Patents

Description

The present invention relates to erythromycin derivatives that are macrolide antibiotics, more specifically,
The present invention relates to a ketolide derivative having a ketone at the 3rd position and an iminoether side chain at the 9th position.

Erythromycin is a Streptomyces actinomycete isolated from Philippine soil in 1952
The first macrolide antibiotic isolated from erythreusk culture and still used today. However, since it is unstable to acid, some patients have insufficient oral absorbability, and the appearance of resistant bacteria is a problem.
Therefore, various erythromycin derivatives have been studied and reported. For example, a derivative in which position 9 of erythromycin is an imino or substituted oxime type is known (Patent Document 1).
However, the derivative has a sugar chain type at the 3-position side chain like erythromycin, and a sufficient antibacterial action against erythromycin-resistant bacteria cannot be expected. In addition, “alkyl substituted with substituted carbamoyl” is also described as a substituent of the substituted oxime, but a specific example is only dimethylcarbamoylmethyl.
On the other hand, as a compound that is also expected to have an effect on erythromycin-resistant bacteria, a ketone type derivative (ketolide) at the 3-position is known (Patent Document 2). Various substituted oximes are described as the group at the 9-position of the derivative. Alkyl substituted with carbamoyl as a substituent of the substituted oxime is also exemplified, but no specific example is described.
The world's first ketolide antibiotics are erythromycin 11
Terithromycin with a heterocyclic alkyl side chain introduced at the position (trade name: Ketec, HMR)
3647) is known (Non-Patent Document 1).
Also, recent trends in macrolide antibiotics have been reported (Non-patent Document 2).
JP-A 63-233985 Japanese Patent Laid-Open No. 4-290893 New Current 14 (18) August 10, 2003 issue Expert Opin. Ther. Patents (2003) 13 (6): 787-805

As a macrolide antibiotic, development of a novel erythromycin derivative which has strong antibacterial activity and is effective against various bacteria including erythromycin resistant bacteria has been demanded.

（式中、
Ｍｅはメチル；
Ｒ１は水素または低級アルキル；
波線は、任意の立体配置；
ＲａおよびＲｂは、それぞれ独立して水素または一緒になって Ｏ＝Ｃ＝；
ｍは、０または１；
Ｘは、−ＮＲ２−ＣＯ−、−ＣＯ−ＮＲ２−、−ＳＯ２−ＮＲ２−、−ＮＲ２−ＳＯ２−（Ｒ２は、置換されていてもよい低級アルキル）、または−Ｏ−ＣＯ−；
Ｙは、単結合または、それぞれ置換されていてもよくヘテロ原子が結合または介在してい
てもよい、１）アルキレン、２）アルケニレン、３）アルキニレンもしくは４）シクロア
ルキレン；Ａｒは、置換されていてもよい炭素環式基または置換されていてもよい複素環式基を示す）
で示される化合物、その製薬上許容される塩もしくは溶媒和物。
（２）ｍが０、Ｘが−ＮＲ２−ＣＯ−（Ｒ２は、置換されていてもよい低級アルキル）または−Ｏ−ＣＯ−、Ｙがそれぞれ置換されていてもよくヘテロ原子が結合または介在していてもよい、アルキレンもしくはアルケニレンである上記１記載の化合物、その製薬上許容される塩もしくは溶媒和物。
（３）ｍが１、Ｒ１が水素、かつＸが−ＣＯ−ＮＲ２−または−ＳＯ２−ＮＲ２−（Ｒ２は、置換されていてもよい低級アルキル）である、上記１記載の化合物、その製薬上許容される塩もしくは溶媒和物。
（４）Ｙが、それぞれ置換されていてもよくＯまたはＮが結合または介在していてもよい、Ｃ２〜５アルキレンもしくはＣ２〜５アルケニレンである、上記１〜３のいずれかに記載の化合物、その製薬上許容される塩もしくは溶媒和物。
（５）Ｙが置換されていてもよい以下に示されるいずれかの構造を有する２価の基である、上記４記載の化合物、その製薬上許容される塩もしくは溶媒和物。

（６）Ｙが−（ＣＨ２）２−または−（ＣＨ２）３−である上記４記載の化合物、その製薬上許容される塩もしくは溶媒和物。
（７）Ｒ１が水素、メチルまたはエチル；ｍが０；Ｘが−ＮＨ−ＣＯ−、かつＹがＣ３〜
Ｃ５アルキレンである上記１記載の化合物、その製薬上許容される塩もしくは溶媒和物。
（８）Ｒ１がメチルまたはエチル；ｍが０；Ｘが−ＮＨ−ＣＯ−、かつＹが−（ＣＨ２）３−である上記１記載の化合物、その製薬上許容される塩もしくは溶媒和物。
（９）Ｒ１が水素、ｍが１；Ｘが−ＣＯ−ＮＨ−、かつＹがＣ２〜Ｃ４アルキレンである
上記１記載の化合物、その製薬上許容される塩もしくは溶媒和物。
（１０）Ｒ１が水素、ｍが１；Ｘが−ＣＯ−ＮＨ−、かつＹが−（ＣＨ２）２−である上記１記載の化合物、その製薬上許容される塩もしくは溶媒和物。
（１１）Ａｒが、置換されていてもよい、アリールもしくはヘテロアリールである、上記
１〜１０のいずれかに記載の化合物、その製薬上許容される塩もしくは溶媒和物。
（１２）Ａｒが、置換されていてもよく他の環と縮合していてもよい、フェニルもしくは
Ｎ原子を１〜４個含有する５または６員の複素環式基である、上記１記載の化合物、その
製薬上許容される塩もしくは溶媒和物。
（１３）上記１〜１２のいずれかに記載の化合物、その製薬上許容される塩もしくは溶媒
和物を含有する医薬組成物。
（１４）上記１〜１２のいずれかに記載の化合物、その製薬上許容される塩もしくは溶媒
和物を含有する抗菌薬。
さらに本発明は、化合物（Ｉ）の合成中間体として有用な以下の化合物も提供する。
（１５）上記１〜１２のいずれかに記載の化合物、その製薬上許容される塩もしくは溶媒
和物の、５位側鎖上のジメチルアミノおよび／またはヒドロキシ部分が保護された化合物。
（１６）式：

（式中、各記号は上記１の場合と同意義）
で示される化合物、その製薬上許容される塩もしくは溶媒和物、またはそれらのジメチル
アミノ、ヒドロキシ、および／またはカルボキシ部分が保護された化合物。 As a result of various studies on structural modification of ketolide, which is an erythromycin derivative, the present inventors can solve the above problems by introducing an iminoether side chain at the 9-position, preferably a side chain having an aryl group or the like at the terminal. The invention shown below was completed.
(1) Formula:

(Where
Me is methyl;
R1 is hydrogen or lower alkyl;
The wavy lines are in any configuration;
Ra and Rb are each independently hydrogen or together O = C =;
m is 0 or 1;
X is -NR2-CO-, -CO-NR2-, -SO2-NR2-, -NR2-SO2- (R2 is optionally substituted lower alkyl), or -O-CO-;
Y is a single bond or each may be substituted or a heteroatom may be bonded or interposed, 1) alkylene, 2) alkenylene, 3) alkynylene or 4) cycloalkylene; Ar is substituted A carbocyclic group which may be substituted or a heterocyclic group which may be substituted)
Or a pharmaceutically acceptable salt or solvate thereof.
(2) m is 0, X is —NR 2 —CO— (R 2 is an optionally substituted lower alkyl), or —O—CO—, Y may be substituted, and a hetero atom is bonded or interposed. 2. The compound according to 1 above, which is alkylene or alkenylene, a pharmaceutically acceptable salt or solvate thereof.
(3) The compound according to 1 above, wherein m is 1, R1 is hydrogen, and X is -CO-NR2- or -SO2-NR2- (R2 is optionally substituted lower alkyl), its pharmaceutical Acceptable salt or solvate.
(4) The compound according to any one of the above 1 to 3, wherein Y is C2-5 alkylene or C2-5 alkenylene, each of which may be substituted and O or N may be bonded or interposed, A pharmaceutically acceptable salt or solvate thereof.
(5) The compound according to the above 4, a pharmaceutically acceptable salt or solvate thereof, wherein Y is a divalent group having any one of the following structures which may be substituted:

(6) The compound according to 4 above, wherein Y is-(CH2) 2- or-(CH2) 3-, a pharmaceutically acceptable salt or solvate thereof.
(7) R1 is hydrogen, methyl or ethyl; m is 0 ; X is -NH-CO- and Y is C3-
2. The compound according to 1 above, which is C5 alkylene, a pharmaceutically acceptable salt or solvate thereof.
(8) R1 is methyl or ethyl; m is 0 ; X is —NH—CO— and Y is — (CH2) 3—, a pharmaceutically acceptable salt or solvate thereof.
(9) The compound according to 1 above, wherein R1 is hydrogen, m is 1, X is -CO-NH-, and Y is C2-C4 alkylene, a pharmaceutically acceptable salt or solvate thereof.
(10) The compound according to 1 above, wherein R1 is hydrogen, m is 1, X is -CO-NH-, and Y is-(CH2) 2-, or a pharmaceutically acceptable salt or solvate thereof.
(11) The compound according to any one of the above 1 to 10, or a pharmaceutically acceptable salt or solvate thereof, wherein Ar is aryl or heteroaryl which may be substituted.
(12) Ar is a 5- or 6-membered heterocyclic group containing 1 to 4 phenyl or N atoms, which may be substituted or condensed with another ring; A compound, pharmaceutically acceptable salt or solvate thereof.
(13) A pharmaceutical composition comprising the compound according to any one of 1 to 12 above, a pharmaceutically acceptable salt or solvate thereof.
(14) An antibacterial agent comprising the compound according to any one of 1 to 12 above, a pharmaceutically acceptable salt or solvate thereof.
The present invention also provides the following compounds useful as synthetic intermediates for compound (I).
(15) A compound in which the dimethylamino and / or hydroxy moiety on the 5-position side chain of the compound according to any one of 1 to 12 above, a pharmaceutically acceptable salt or solvate thereof is protected.
(16) Formula:

(In the formula, each symbol has the same meaning as in the above case 1)
Or a pharmaceutically acceptable salt or solvate thereof, or a compound in which a dimethylamino, hydroxy, and / or carboxy moiety thereof is protected.

Compound (I) has antibacterial activity equivalent to or higher than that of erythromycin. In particular, it is effective against Haemophilus influenzae, pneumococci and various erythromycin-resistant bacteria that are the main causative agents of respiratory infections. Also, pharmacokinetics such as lung migration and absorption are good. The present invention further provides a synthetic intermediate of compound (I) such as compound (II).

ｍは、０または１を表わす。
Ｘは、−ＮＲ２−ＣＯ−、−ＣＯ−ＮＲ２−、−ＳＯ２−ＮＲ２−、−ＮＲ２−ＳＯ２−（Ｒ２は、置換されていてもよい低級アルキル）、または−Ｏ−ＣＯ−を表わすが、好ましくは−ＮＲ２−ＣＯ−または−ＣＯ−ＮＲ２−である。
Ｙは、単結合または、それぞれ置換されていてもよくヘテロ原子（例：Ｏ、Ｓ、ＳＯ、
ＳＯ２、ＮＨ、ＮＲ（Ｒは置換されていてもよい低級アルキル、置換されていてもよいア
ミノ低級アルキル等））が結合または介在していてもよい、１）アルキレン、２）アルケ
ニレンもしくは３）シクロアルキレンを表わす。該ヘテロ原子は１〜３個存在し得る。「置換されていてもよく」の置換基としては前記置換基群Ｂから選択される基や、ＯＨ、＝Ｏ、−Ｏ（ＣＨ２）２Ｏ−などが例示される。より好ましくは置換されていてもよい以下の基である。

Ａｒは、置換されていてもよい炭素環式基または置換されていてもよい複素環式基を示
すが、好ましくは後記実施例に示す基であり、より好ましくはフェニル、ナフタレニル、
ピリジル、キノリル、イソキノリル、フタラジニル、ピロリル、チオフェニル、チアゾリ
ル、イソチアゾリル、オキサゾリル、イソオキサゾリル、アントラセニル、またはこれら
とベンゼン、シクロアルキル、シクロアルケニル、または他の複素環との縮合環などであ
り、さらに好ましくはフェニル、キノリル、イソキノリル、フタラジニルなどである。
本発明化合物のさらに好ましい態様を以下に例示する。
（１）ｍが０、Ｘが−ＮＲ２−ＣＯ−（Ｒ２は、置換されていてもよい低級アルキル）または−Ｏ−ＣＯ−、Ｙがそれぞれ置換されていてもよくヘテロ原子が結合または介在していてもよい、アルキレンもしくはアルケニレンである場合。
（２）ｍが１、Ｒ１が水素、かつＸが−ＣＯ−ＮＲ２−または−ＳＯ２−ＮＲ２−（Ｒ２は、置換されていてもよい低級アルキル）である場合。
（３）Ｙが、それぞれ置換されていてもよくＯまたはＮが結合または介在していてもよい、Ｃ２〜５のアルキレンもしくはアルケニレン、より好ましくは−（ＣＨ２）２−または−（ＣＨ２）３−である場合。
（４）Ｒ１が水素、メチルまたはエチル；ｍが０；Ｘが−ＮＨ−ＣＯ−、かつＹがＣ３〜
Ｃ５アルキレン、好ましくはＹが−（ＣＨ２）３−である場合。
（５）Ｒ１が水素、ｍが１；Ｘが−ＣＯ−ＮＨ−、かつＹがＣ２〜Ｃ４アルキレン、好ま
しくは−（ＣＨ２）２−である場合。
（６）Ａｒが、置換されていてもよい、アリールもしくはヘテロアリール、好ましくは、
置換されていてもよく他の環と縮合していてもよい、フェニルもしくはＮ原子を１〜４個
含有する５または６員の複素環式基である場合。
（７）９位オキシムの酸素原子とＡｒとの間のスペーサー部分を直鎖的に構成する原子（炭素原子および／またはヘテロ原子）の数としては、好ましくは５〜８個、より好ましくは６〜７個である。

本発明化合物の一般的製法について説明する。
化合物（Ｉ）はエリスロマイシン誘導体であるので、基本的にはエリスロマイシンまた
はその公知誘導体を出発原料として合成できる。
好ましくは、化合物（Ｉ）は、３位ケトン型のエリスロマイシン誘導体（ケトライド）
の９位にイミノエーテル型側鎖を導入することにより得られる。好ましくは、まず９位末
端にカルボキシル基を有する中間体化合物（II）、もしくはアミノ基を有する中間体を調
製した後、当業者に周知の方法に準じてアミド化、エステル化、アジド化、アシル化、ス
ルホニル化等行うことにより化合物（Ｉ）を得る。
化合物（II）は、好ましくは、後記実施例１に示されるように、特開昭６３−２３３９
８５号等に記載の方法に準じて得られる９位オキシム型の化合物（例：化合物１）の３位
糖鎖エーテル部分をケトンに変換した後、所望により11位および12位のヒドロキシ部分
をサイクリックカーボネート化し、さらに９位末端部分をオゾン酸化によりアルデヒド、
これをさらに酸化しカルボキシル基とすることにより得られる。また別法として、実施例
３に示されるように９位ヒドロキシイミノ誘導体（例：化合物５Ｂ）の９位に、求核反応
により保護されたカルボキシアルキル側鎖を導入した後、脱保護することにより化合物
（II）を得てもよい。
なお上記反応において、５位の糖鎖上のアミノおよび／またはヒドロキシ部分は、所望
により保護されていてもよく、該保護および脱保護反応は当業者に周知の方法により行え
る。

本発明はさらに、化合物（Ｉ）の合成中間体として、化合物（Ｉ）の５位糖鎖上のジメ
チルアミノおよび／またはヒドロキシ部分が保護された化合物を提供する。さらに前記化
合物（II）、その製薬上許容される塩もしくは溶媒和物、またはそれらのジメチルアミノ、ヒドロキシ、および／またはカルボキシ部分が保護された化合物も提供する。ジメチルアミノ、ヒドロキシ、およびカルボキシ部分の各保護基は、以下のＰ１〜Ｐ３で示され、化合物（Ｉ）の場合も同様である。

アミノ基の保護基(Ｐ１)の代表的な例およびその脱離法は、例えば「新実験化学講座」第１４巻第２５５５−２５６９頁に記載されており、例えば、アシル型のものとして、ホルミル（ＨＣl／ＣＨ3ＯＨで脱離）、アセチル（酸またはアルカリで脱離）等の低級アルカノイル基、２−クロロプロピオニル（酸またはアルカリで脱離）等のハロ低級アルカノイル基、ベンゾイル（酸またはアルカリで脱離）等のアリールカルボニル基、フェニルプロピオニル（酸またはアルカリで脱離）等のアリール低級アルカノイル基、ウレタン型のものとして、メトキシカルボニル、エトキシカルボニル、第３級ブトキシカルボニル（ＨＢrまたはＨＣl／ＡcＯＨで脱離）等の低級アルコキシカルボニル基、ベンジルオキシカルボニル（Ｈ2／Ｐd、ＨＩまたはＨＢrまたはＨＣl／ＡcＯＨ等で脱離）、２−（ｐ−ビフェニル）イソプロポキシカルボニル（ＡcＯＨ／ＨＣＯＯＨ、トリフルオロ酢酸等で脱離）等のアリール低級アルキルオキシカルボニル基、アラルキル型のものとして、ベンジル（Ｈ2／Ｐd、Ｎa／ＮＨ3で脱離）、トリチル（Ｈ2／Ｐdで脱離）等のアリール低級アルキル基、およびアゾメチン型のものとして、ベンジリデン（Ｈ2／Ｐd、ＨＣlで脱離）等のアリール低級アルキリデン基などが用いられる。
ヒドロキシ基保護基（Ｐ２）の代表的な例およびその脱離法は、例えば「新実験化学講
座」第１４巻第２４９７−２５１６頁に記載されており、例えば、エーテル型のものとし
て、メチルエーテル(三塩化ホウ素で脱離)、アリルエーテル(プロペニルエーテルに異性化後酸触媒加水分解)、ベンジルエーテル(接触水素分解)、トリアリールメチルエーテル(酢酸で脱離)等、アセタール型のものとして、テトラヒドロピラニルエーテル(酸触媒加水分解で脱離)等、エステル型のものとして、酢酸エステル(塩基加水分解で脱離)、ギ酸エステル(ＫＨＣＯ3−Ｈ2Ｏ−ＣＨ3ＯＨで脱離)またはトリフルオロ酢酸(ＫＨＣＯ3−ＣＨ3ＯＨで脱離)、クロロ酢酸エステル(Ｃ6Ｈ5Ｎ−Ｃ2Ｈ5ＯＨで脱離)、メトキシおよびフェノキシ酢酸エステル(ＮＨ3−ＣＨ3ＯＨで脱離)などの置換酢酸エステル、安息香酸エステルおよびp−ニトロ安息香酸エステル(塩基加水分解で脱離)等、エトキシカルボニル(ＫＯＨ−ＣＨ3ＯＨで脱離)、アリルオキシカルボニル(Ｎi(ＣＯ)４，Ｍe2ＣＨ2ＣＨ2Ｍe2で脱離)、フェニルカルバモイル(ＣＨ3ＯＮa−熱ＣＨ3ＯＨで脱離)、ベンジルチオカルボニル(Ｈ2Ｏ2−ＣＨ3ＣＯ2Ｈで脱離)等の炭酸エステル等、硝酸エステル(Ｎa2Ｓ等で脱離)、スルホン酸エステル(Ｎa−Ｈg−ＣＨ3ＯＨ)などの非カルボン酸エステルなどが用いられる。
カルボキシ保護基（Ｐ３）としては、置換されていてもよいＣ1-6アルキル、Ｃ2-6アル
ケニル、Ｃ3-10シクロアルキル、Ｃ3-10シクロアルキルＣ1-6アルキル、置換されていて
もよいＣ6-10アリール、置換されていてもよいＣ7-12アラルキル、ジＣ6-10アリールメ
チル、トリＣ6-10アリールメチル、置換シリルなどが用いられる。
本発明は、化合物（Ｉ）、（II）のプロドラッグ、それらの製薬上許容される塩及びそ
れらの溶媒和物も提供する。本発明化合物の理論上可能なすべての互変異性体、幾何異性
体等も、本発明の範囲内である。
プロドラッグは、化学的又は代謝的に分解できる基を有する本発明化合物の誘導体であ
り、加溶媒分解により又は生理学的条件下でインビボにおいて薬学的に活性な本発明化合
物となる化合物である。適当なプロドラッグ誘導体を選択する方法および製造する方法は、例えばDesign of Prodrugs, Elsevier, Amsterdam 1985に記載されている。
本発明化合物の製薬上許容される塩としては、塩基性塩として、例えば、ナトリウム塩、カリウム塩等のアルカリ金属塩；カルシウム塩、マグネシウム塩等のアルカリ土類金属塩；アンモニウム塩；トリメチルアミン塩、トリエチルアミン塩、ジシクロヘキシルアミン塩、エタノールアミン塩、ジエタノールアミン塩、トリエタノールアミン塩、ブロカイン塩、メグルミン塩、ジエタノールアミン塩またはエチレンジアミン塩等の脂肪族アミン塩；N,N-ジベンジルエチレンジアミン、ベネタミン塩等のアラルキルアミン塩；ピリジン塩、ピコリン塩、キノリン塩、イソキノリン塩等のヘテロ環芳香族アミン塩；テトラメチルアンモニウム塩、テトラエチルアモニウム塩、ベンジルトリメチルアンモニウム塩、ベンジルトリエチルアンモニウム塩、ベンジルトリブチルアンモニウム塩、メチルトリオクチルアンモニウム塩、テトラブチルアンモニウム塩等の第４級アンモニウム塩；アルギニン塩,リジン塩等の塩基性アミノ酸塩等が挙げられる。酸性塩としては、例えば、塩酸塩、硫酸塩、硝酸塩、リン酸塩、炭酸塩、炭酸水素塩、過塩素酸塩等の無機酸塩；酢酸塩、プロピオン酸塩、乳酸塩、マレイン酸塩、フマール酸塩、酒石酸塩、リンゴ酸塩、クエン酸塩、アスコルビン酸塩等の有機酸塩；メタンスルホン酸塩、イセチオン酸塩、ベンゼンスルホン酸塩、p-トルエンスルホン酸塩等のスルホン酸塩；アスパラギン酸塩、グルタミン酸塩等の酸性アミノ酸等が挙げられる。
本発明化合物の溶媒和物としては、アルコール和物や水和物物等が挙げられる。
本発明化合物は、経口的又は非経口的に投与することができる。経口投与による場合、
本発明化合物は通常の製剤、例えば、錠剤、散剤、顆粒剤、カプセル剤等の固形剤；水剤；油性懸濁剤；又はシロップ剤もしくはエリキシル剤等の液剤のいずれかの剤形としても用いることができる。非経口投与による場合、本発明化合物は、水性又は油性懸濁注射剤、点鼻液として用いることができる。その調製に際しては、慣用の賦形剤、結合剤、滑沢剤、水性溶剤、油性溶剤、乳化剤、懸濁化剤、保存剤、安定剤等を任意に用いることができる。なお、抗HIV薬としては、特に経口剤が好ましい。
本発明の製剤は、治療有効量の本発明化合物を製薬上許容される担体又は希釈剤ととも
に組み合わせる（例えば混合する）ことによって製造される。本発明化合物の製剤は、周
知の、容易に入手できる成分を用いて既知の方法により製造される。
本発明化合物の投与量は、投与方法、患者の年齢、体重、状態および疾患の種類によっ
ても異なるが、例えば、経口投与の場合、成人１日あたり約０．０５ｍｇ〜３０００ｍｇ
を、要すれば分割して投与すればよい。また、非経口投与の場合、成人１日あたり約０．
０１ｍｇ〜１０００ｍｇを投与する。 Terms used in this specification will be explained below. Each term alone or in combination with other terms has the following meanings unless otherwise specified.
“Alkyl” means a linear or branched alkyl group having 1 to 10 carbon atoms, such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert- Examples include butyl, n-pentyl, isopentyl, neopentyl, tert-pentyl, n-hexyl, isohexyl, n-heptyl, n-octyl, n-nonyl, n-decyl and the like. Preferably, it is a lower alkyl (1 to 6 carbon atoms), more preferably a lower alkyl having 1 to 4 carbon atoms, such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl. Tert-butyl, n-pentyl, isopentyl, neopentyl, tert-pentyl, n-hexyl and isohexyl.
“Alkenyl” means a linear or branched alkenyl having 2 to 8 carbon atoms having one or more double bonds to the above “alkyl”, and examples thereof include vinyl, 1-propenyl, 2 -Propenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1,3-butadienyl, 3-methyl-2-butenyl and the like.
“Cycloalkyl” means a cyclic saturated hydrocarbon group having 3 to 15 carbon atoms, and examples thereof include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl and the like. Preferably, it is a C3-C6 cycloalkyl.
“Cycloalkenyl” means a cyclic non-aromatic hydrocarbon group having 3 to 10 carbon atoms, such as cyclopropenyl (eg, 1-cyclopropenyl), cyclobutenyl (eg, 1-cyclohexenyl).
Cyclobutenyl), cyclopentenyl (eg 1-cyclopenten-1-yl, 2-cyclopenten-1-yl, 3-cyclopenten-1-yl), cyclohexenyl (eg 1-cyclohexen-1-yl, 2-cyclohexene- 1-yl, 3-cyclohexen-1-yl), cycloheptenyl (eg 1-cycloheptenyl), cyclooctenyl (eg 1-cyclooctenyl) and the like.
“Alkylene” is a linear or branched lower alkylene having 1 to 10 carbon atoms, preferably 1 to 6 carbon atoms, more preferably 2 to 5 carbon atoms, and still more preferably 3 to 4 carbon atoms. For example, methylene, ethylene, trimethylene, propylene, tetramethylene, ethylethylene, pentamethylene or hexamethylene.
“Alkenylene” is a linear or branched lower alkenylene group having 2 to 10 carbon atoms, preferably 2 to 6 carbon atoms, having one or more double bonds to the above “lower alkylene”. Meaning, for example, vinylene, propenylene or butenylene. Preferably,
C2-C3 linear lower alkenylene, for example, vinylene or propenylene.
“Alkynylene” means a linear or branched lower alkynylene group having 2 to 10 carbon atoms, preferably 2 to 6 carbon atoms, having one or more triple bonds to the above “lower alkylene”. Examples thereof include -C≡C- and -C≡C-CH2-.
“Cycloalkylene” preferably means a cycloalkylene having 3 to 10 carbon atoms,
Examples thereof include cyclopropylene, cyclobutylene, cyclopentylene, cyclohexylene, cycloheptylene, and cyclooctylene. Preferably, it is a C3-C6 cycloalkylene.
The “carbocyclic group” means a saturated or unsaturated carbocyclic group preferably having 3 to 10 carbon atoms, and also includes “aryl”, “cycloalkyl”, and “cycloalkenyl”. These are condensed with other carbocycles and may be bicyclic or tricyclic.
“Aryl” means a monocyclic aromatic hydrocarbon group (eg, phenyl) or a polycyclic aromatic hydrocarbon group (eg, 1-naphthyl, 2-naphthyl, 1-anthryl, 2-anthryl, 9-anthryl, 1- Phenanthryl, 2-phenanthryl, 3-phenanthryl, 4-phenanthryl, 9-phenanthryl and the like. Preferable is phenyl or naphthyl (1-naphthyl, 2-naphthyl).
“Heterocyclic group” means “heterocycle” or “heteroaryl”.
“Heterocycle” is a non-aromatic heterocyclic group having a bond at any substitutable position having at least one nitrogen atom, oxygen atom and / or sulfur atom in the ring (preferably 5 to 5). 7-membered ring), for example, 1-pyrrolinyl, 2-pyrrolinyl, 3-pyrrolinyl, 1-pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 1-imidazolinyl, 2-imidazolinyl, 4-
Imidazolinyl, 1-imidazolidinyl, 2-imidazolidinyl, 4-imidazolidinyl, 1-pyrazolinyl, 3-pyrazolinyl, 4-pyrazolinyl, 1-pyrazolidinyl, 3-pyrazolidinyl, 4-pyrazolidinyl, piperidino, 2-piperidyl, 3-piperidyl, 4- Examples include piperidyl, 1-piperazinyl, 2-piperazinyl, 2-morpholinyl, 3-morpholinyl, morpholino, tetrahydropyranyl and the like. The “non-aromatic heterocyclic group” may be saturated or unsaturated as long as it is non-aromatic.
“Heteroaryl” means monocyclic aromatic heterocyclic groups and fused aromatic heterocyclic groups.
The monocyclic aromatic heterocyclic group has 1 to 4 oxygen atoms, sulfur atoms, and / or nitrogen atoms in the ring.
It means a group optionally having a bond at any substitutable position derived from a 5- to 8-membered aromatic ring which may be included.
The condensed aromatic heterocyclic group has 1 to 4 oxygen atoms, sulfur atoms, and / or nitrogen atoms in the ring.
Optionally substituted 5-8 membered aromatic ring is fused with 1 to 4 5-8 membered aromatic carbocycle or other 5-8 membered aromatic heterocycle It means a group which may have a bond at any position.
“Heteroaryl” includes, for example, furyl (eg, 2-furyl, 3-furyl), thienyl (eg, 2-thienyl, 3-thienyl), pyrrolyl (eg, 1-pyrrolyl, 2-pyrrolyl, 3-pyrrolyl). ), Imidazolyl (eg 1-imidazolyl, 2-imidazolyl, 4-imidazolyl), pyrazolyl (eg 1-pyrazolyl, 3-pyrazolyl, 4-pyrazolyl), triazolyl (eg 1,2,4-triazole-1- Yl, 1,2,4-triazol-3-yl, 1,2,4-triazol-4-yl), tetrazolyl (eg 1-tetrazolyl, 2-tetrazolyl, 5-tetrazolyl), oxazolyl (eg 2- Oxazolyl, 4-oxazolyl, 5-oxazolyl) isoxazolyl (eg 3-isoxazolyl, 4-isoxazolyl, 5-isoxazolyl), thiazolyl (eg 2-thiazolyl, 4-thiazolyl, 5- Azolyl), thiadiazolyl, isothiazolyl (eg 3-isothiazolyl, 4-isothiazolyl, 5-isothiazolyl), pyridyl (eg 2-pyridyl, 3-pyridyl, 4-pyridyl), pyridazinyl (eg 3-pyridazinyl, 4-pyridazinyl) ), Pyrimidinyl (eg, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl), furazanyl (eg, 3-furazinyl), pyrazinyl (eg, 2-pyrazinyl), oxadiazolyl (eg, 1,3,4-oxadiazole) -2-yl), benzofuryl (eg, 2-benzo [b] furyl, 3-benzo [b] furyl, 4-benzo [b] furyl, 5-benzo [b] furyl, 6-benzo [b] furyl, 7-benzo [b] furyl), benzothienyl (eg, 2-benzo [b] thienyl, 3-benzo [b] thienyl, 4-benzo [b] thienyl, 5-benzo [b] thienyl, 6-benzo [ b] thienyl, 7- Benzo [b] thienyl), benzimidazolyl (eg, 1-benzimidazolyl, 2-benzoimidazolyl, 4-benzoimidazolyl, 5-benzoimidazolyl), dibenzofuryl, benzoxazolyl, quinoxalyl (eg, 2-quinoxalinyl, 5-quinoxalinyl, 6-quinoxalinyl), cinnolinyl (eg 3-cinnolinyl, 4-cinnolinyl, 5-cinnolinyl, 6-cinnolinyl, 7-cinnolinyl, 8-cinnolinyl), quinazolyl (eg 2-quinazolinyl, 4-quinazolinyl, 5-quinazolinyl, 6-quinazolinyl, 7-quinazolinyl, 8-quinazolinyl), quinolyl (eg, 2-quinolyl, 3-quinolyl, 4-quinolyl, 5-quinolyl, 6-quinolyl, 7-quinolyl, 8-quinolyl), phthalazinyl (eg, 1-phthalazinyl, 5-phthalazinyl, 6-phthalazinyl), isoquinolyl (eg 1 -Isoquinolyl, 3-isoquinolyl, 4-isoquinolyl, 5-isoquinolyl, 6-isoquinolyl, 7-isoquinolyl, 8-isoquinolyl), prill, pteridinyl (eg, 2-pteridinyl, 4-pteridinyl, 6-pteridinyl, 7-pteridinyl) Carbazolyl, phenanthridinyl, acridinyl (eg 1-acridinyl, 2-acridinyl, 3-acridinyl, 4-acridinyl, 9-acridinyl), indolyl (eg 1-indolyl, 2-indolyl, 3-indolyl, 4 -Indolyl, 5-indolyl, 6-indolyl, 7-indolyl), isoindolyl, fanadinyl (eg 1-phenazinyl, 2-phenazinyl) or phenothiazinyl (eg 1-phenothiazinyl, 2-phenothiazinyl, 3-phenothiazinyl) , 4-phenothiazinyl) and the like.
The alkyl part of “alkoxy” has the same meaning as the above “alkyl”.
As, for example, methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy,
Examples include isobutoxy and tert-butoxy.
“Alkynyl” has 2 carbon atoms having one or more triple bonds to the above “alkyl”.
Means -8 alkynyls, for example, ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl and the like.
“Alkylsulfonyl” means a sulfonyl substituted with the above “alkyl”, for example, methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, isobutylsulfonyl, sec-butylsulfonyl, tert-butyl Sulfonyl, n-pentylsulfonyl, isopentylsulfonyl, neopentylsulfonyl, tert-pentylsulfonyl, n-hexylsulfonyl, isohexylsulfonyl, n-heptylsulfonyl, n-octylsulfonyl, n-nonyl Examples include sulfonyl and n-decylsulfonyl. Preferred is methylsulfonyl.
The substituents of “optionally substituted amino” and “optionally substituted carbamoyl” include optionally substituted alkyl (eg, methyl, ethyl, isopropyl, benzyl, carbamoylalkyl (eg, carbamoylmethyl). ), Mono- or dialkylcarbamoylalkyl (eg dimethylcarbamoylethyl), hydroxyalkyl, heterocyclealkyl (eg morpholinoethyl, tetrahydropyranylethyl), alkoxycarbonylalkyl (eg ethoxycarbonylmethyl, ethoxycarbonylethyl), mono or Dialkylaminoalkyl (eg, dimethylaminoethyl), etc., alkoxyalkyl (eg, methoxyethyl, ethoxymethyl, ethoxyethyl, isopropoxyethyl, etc.), acyl (eg, formyl) Optionally substituted alkylcarbonyl (eg acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, pivaloyl, hexanoyl, octanoyl, methoxyethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, ethoxycarbonylmethylcarbonyl, alkoxy Alkylcarbonyl (eg methoxyethylcarbonyl), alkylcarbamoylalkylcarbonyl (eg methylcarbamoylethylcarbonyl), alkoxycarbonylacetyl etc., optionally substituted arylcarbonyl (eg benzoyl, toluoyl etc.), substituted Aralkyl (eg benzyl, 4-fluorobenzyl etc.), hydroxy, optionally substituted alkylsulfonyl (eg methanesulfonyl, ethane) Sulfonyl, isopropylsulfonyl, 2,2,2-trifluoroethanesulfonyl, benzylsulfonyl, methoxyethylsulfonyl, etc.), arylsulfonyl optionally substituted with alkyl or halogen (eg, benzenesulfonyl, toluenesulfonyl, 4-fluorobenzene) Sulfonyl), cycloalkyl (eg, cyclopropyl, etc.), aryl optionally substituted with alkyl (eg, phenyl, trityl, etc.), alkylaminosulfonyl (eg, methylaminosulfonyl, dimethylaminisulfonyl, etc.), alkylaminocarbonyl (For example, dimethylaminocarbonyl, etc.), alkoxycarbonyl (for example, ethoxycarbonyl, etc.), cycloalkylcarbonyl (for example, cyclopropylcarbonyl, cyclohexylcarbohydrate) ), Optionally substituted sulfamoyl (eg, sulfamoyl, methylsulfamoyl, dimethylsulfamoyl, etc.), alkylcarbonylamino (eg, methylcarbonylamino), heterocycle (eg, morpholino, tetrahydropyranyl) And optionally substituted amino (eg mono- or dialkylamino (eg dimethylamino), formylamino) and the like. Preferably it is methyl. The substituent may be mono- or di-substituted.
The amino group of “optionally substituted amino” and “optionally substituted carbamoyl” contains a sulfur atom and / or an oxygen atom in the ring together with two adjacent nitrogen atoms of the amino group. Optionally containing a nitrogen-containing heterocycle (preferably a 5- to 7-membered ring and preferably saturated), which ring may be substituted with oxo or hydroxy. The sulfur atom forming the ring may be substituted with oxo. For example, 5 or 6 such as piperazinyl, piperidino, morpholino, pyrrolidino, thiazinan-2-yl, 2-oxopiperidino, 2-oxopyrrolidino, 1,1-dioxide-1,2-thiazinan-2-yl, 4-hydroxymorpholino A member ring is preferred.
“Alkylthio” means a group in which the above “alkyl” is substituted with a sulfur atom. For example, methylthio, ethylthio, n-propylthio, isopropylthio, n-butylthio, isobutylthio, sec-butylthio, tert-butylthio, n- Examples include pentylthio, isopentylthio, neopentylthio, tert-pentylthio, n-hexylthio, isohexylthio, n-heptylthio, n-octylthio, n-nonylthio, n-decylthio and the like. A group in which an alkyl having 1 to 6 carbon atoms is substituted with a sulfur atom is preferable.
“Haloalkyl” means the above “alkyl” substituted with one or more halogens.
In particular, an alkyl halide having 1 to 3 carbon atoms is preferable, for example, trifluoromethyl,
Examples include chloromethyl, dichloromethyl, 1,1-dichloroethyl, 2,2,2-trichloroethyl and the like.
“Haloalkoxy” means a group in which the above “haloalkyl” is substituted with an oxygen atom, and examples thereof include trifluoromethoxy, chloromethoxy, dichloromethoxy, 1,1-dichloroethoxy, 2,2,2-trichloroethoxy, and the like. Can be mentioned.
“Acyl” means a carbonyl substituted with the above “alkyl” and a carbonyl substituted with the above “aryl”, such as acetyl, propionyl, butyryl, isobutyryl,
Examples include valeryl, isovaleryl, pivaloyl, hexanoyl, octanoyl, lauroyl, benzoyl and the like.
“Optionally substituted lower alkyl”, “optionally substituted carbocyclic group”, “optionally substituted heterocyclic group”, “optionally substituted alkylene”, “substituted” Optionally substituted alkenylene "," optionally substituted alkynylene "," optionally substituted cycloalkylene "," optionally substituted aryl ", or" optionally substituted heteroaryl ", etc. When has a substituent, arbitrary positions may be substituted with the same or different 1 to 4 groups selected from the substituent group B.
Examples of the substituent group B include, for example, hydroxy, carboxy, halogen (F, Cl, Br, I), haloalkyl (for example, CF3, CH2CF3, CH2CCl3, etc.), haloalkoxy (for example, OCF3), alkyl (for example, Methyl, ethyl, isopropyl, tert-butyl, etc.), alkenyl (eg, vinyl), alkynyl (eg, ethynyl), cycloalkyl (eg, cyclopropyl), cycloalkenyl (eg, cyclopropenyl), alkoxy (eg, methoxy, Ethoxy, propoxy, butoxy, etc.), alkenyloxy (eg, vinyloxy, allyloxy, etc.), alkoxycarbonyl (eg, methoxycarbonyl, ethoxycarbonyl, tert-butoxycarbonyl, etc.), nitro, nitroso, optionally substituted amino (eg, , Alkylamino (e.g., Methylamino, ethylamino, dimethylamino etc.), acylamino (eg acetylamino, benzoylamino etc.), aralkylamino (eg benzylamino, tritylamino), hydroxyamino etc.), azide, aryl (eg phenyl etc.), Aralkyl (eg benzyl etc.), cyano, isocyano, isocyanato, thiocyanato, isothiocyanato, mercapto, alkylthio (eg methylthio etc.), alkylsulfonyl (eg methanesulfonyl, ethanesulfonyl), optionally substituted carbamoyl (eg Alkylcarbamoyl (eg, methylcarbamoyl, ethylcarbamoyl, dimethylcarbamoyl, etc.), sulfamoyl, acyl (eg, formyl, acetyl, etc.), formyloxy, halopho Examples include mil, oxalolo, thioformyl, thiocarboxy, dithiocarboxy, thiocarbamoyl, sulfino, sulfo, sulfoamino, hydrazino, azide, ureido, amidino, guanidino, phthalimide, oxo, or various substituents shown in the examples below. .
(Preferred embodiment)
R1 is hydrogen or lower alkyl, preferably hydrogen, methyl or ethyl.
From the viewpoint of the ability of compound (I) to migrate to the lung, R1 is more preferably methyl or ethyl.
The wavy line indicates an arbitrary configuration, and when R1 is lower alkyl, the stereo display of the carbon to which R1 is bonded may be R or S, but is preferably R.
Ra and Rb each independently represent hydrogen or together represent O═C═, but preferably O═C═. In this case, the structures at the 11th and 12th positions are as follows.

m represents 0 or 1.
X represents -NR2-CO-, -CO-NR2-, -SO2-NR2-, -NR2-SO2- (R2 is optionally substituted lower alkyl), or -O-CO-, -NR2-CO- or -CO-NR2- is preferable.
Y is a single bond or a hetero atom which may be substituted each (eg, O, S, SO,
SO2, NH, NR (R is optionally substituted lower alkyl, optionally substituted amino lower alkyl, etc.)) may be bonded or intervened 1) alkylene, 2) alkenylene or 3) cyclo Represents alkylene. There may be 1 to 3 heteroatoms. Examples of the “optionally substituted” substituent include a group selected from the substituent group B, OH, ═O, —O (CH 2) 2 O—, and the like. More preferred are the following groups which may be substituted.

Ar represents an optionally substituted carbocyclic group or an optionally substituted heterocyclic group, preferably a group shown in the Examples below, more preferably phenyl, naphthalenyl,
Pyridyl, quinolyl, isoquinolyl, phthalazinyl, pyrrolyl, thiophenyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, anthracenyl, or condensed rings thereof with benzene, cycloalkyl, cycloalkenyl, or other heterocycles, more preferably phenyl Quinolyl, isoquinolyl, phthalazinyl, and the like.
Further preferred embodiments of the compound of the present invention are exemplified below.
(1) m is 0, X is —NR 2 —CO— (R 2 is an optionally substituted lower alkyl), or —O—CO—, Y may be substituted, and a hetero atom is bonded or interposed. In the case of alkylene or alkenylene.
(2) When m is 1, R1 is hydrogen, and X is -CO-NR2- or -SO2-NR2- (R2 is optionally substituted lower alkyl).
(3) C2-5 alkylene or alkenylene, each of which Y may be substituted and O or N may be bonded or interposed, more preferably-(CH2) 2- or-(CH2) 3- If it is.
(4) R1 is hydrogen, methyl or ethyl; m is 0 ; X is -NH-CO- and Y is C3-
C5 alkylene, preferably when Y is — (CH 2) 3 —.
(5) When R1 is hydrogen, m is 1, X is -CO-NH-, and Y is C2-C4 alkylene, preferably-(CH2) 2-.
(6) Ar is optionally substituted aryl or heteroaryl, preferably
When it is a 5- or 6-membered heterocyclic group containing 1 to 4 phenyl or N atoms, which may be substituted or condensed with other rings.
(7) The number of atoms (carbon atoms and / or heteroatoms) constituting the spacer portion linearly between the oxygen atom of Ar 9-position oxime and Ar is preferably 5 to 8, more preferably 6 ~ 7.

A general method for producing the compound of the present invention will be described.
Since compound (I) is an erythromycin derivative, it can be basically synthesized using erythromycin or a known derivative thereof as a starting material.
Preferably, compound (I) is an erythromycin derivative (ketolide) in the 3-position ketone type
It is obtained by introducing an imino ether side chain at the 9-position. Preferably, first, an intermediate compound (II) having a carboxyl group at the 9-position end or an intermediate having an amino group is prepared, and then amidation, esterification, azidation, acylation according to methods well known to those skilled in the art. Compound (I) is obtained by carrying out the conversion, sulfonylation and the like.
Compound (II) is preferably used as disclosed in Example 1 below, as disclosed in JP-A-62-2339.
The 9-position oxime-type compound (eg, Compound 1) obtained in accordance with the method described in No. 85 and the like is converted to a ketone at the 3-position sugar chain ether, and the hydroxy positions at the 11-position and 12-position are optionally cyclized. Click carbonate, and the 9-position end is oxidised by ozone oxidation,
This can be obtained by further oxidizing to a carboxyl group. Alternatively, as shown in Example 3, by introducing a carboxyalkyl side chain protected by a nucleophilic reaction at the 9-position of the 9-position hydroxyimino derivative (eg, compound 5B), followed by deprotection. Compound (II) may be obtained.
In the above reaction, the amino and / or hydroxy moiety on the sugar chain at the 5-position may be protected as desired, and the protection and deprotection can be carried out by methods well known to those skilled in the art.

The present invention further provides a compound in which the dimethylamino and / or hydroxy moiety on the 5-position sugar chain of compound (I) is protected as a synthetic intermediate of compound (I). Furthermore, the compound (II), a pharmaceutically acceptable salt or solvate thereof, or a compound in which the dimethylamino, hydroxy, and / or carboxy moiety thereof is protected is also provided. The protecting groups for the dimethylamino, hydroxy, and carboxy moieties are represented by the following P1 to P3, and the same applies to the compound (I).

Representative examples of amino-protecting groups (P1) and their elimination methods are described, for example, in “New Experimental Chemistry Course”, Vol. 14, pp. 2555-2569. (Elimination with HCl / CH3OH), lower alkanoyl groups such as acetyl (elimination with acid or alkali), halo lower alkanoyl groups such as 2-chloropropionyl (elimination with acid or alkali), benzoyl (desorption with acid or alkali) Arylcarbonyl groups such as phenylpropionyl (eliminated with acid or alkali), urethane type, methoxycarbonyl, ethoxycarbonyl, tertiary butoxycarbonyl (HBr or HCl / AcOH) A lower alkoxycarbonyl group such as benzyloxycarbonyl (H2 / Pd, HI or H) r or HCl / AcOH, etc.), aryl (lower alkyloxycarbonyl) groups such as 2- (p-biphenyl) isopropoxycarbonyl (acOH / HCOOH, trifluoroacetic acid, etc.), aralkyl type benzyl, etc. Aryl lower alkyl groups such as (desorbed with H2 / Pd, Na / NH3), trityl (desorbed with H2 / Pd), and aryl such as benzylidene (desorbed with H2 / Pd, HCl) as azomethine type A lower alkylidene group or the like is used.
Representative examples of the hydroxy-protecting group (P2) and the elimination method thereof are described in, for example, “New Experimental Chemistry Course”, Vol. 14, pp. 2497-2516. (Elimination with boron trichloride), allyl ether (acid-catalyzed hydrolysis after isomerization to propenyl ether), benzyl ether (catalytic hydrogenolysis), triarylmethyl ether (elimination with acetic acid), etc. As ester-type compounds such as tetrahydropyranyl ether (eliminated by acid-catalyzed hydrolysis), acetic acid ester (eliminated by basic hydrolysis), formic acid ester (eliminated by KHCO3-H2O-CH3OH) or trifluoroacetic acid (KHCO3- Detached with CH3OH), chloroacetate (eliminated with C6H5N-C2H5OH), methoxy and phenoxyacetate (eliminated with NH3-CH3OH) Substituted acetate ester, benzoate ester and p-nitrobenzoate ester (eliminated by basic hydrolysis), etc., ethoxycarbonyl (eliminated with KOH-CH3OH), allyloxycarbonyl (Ni (CO) 4, Me2CH2CH2Me2) ), Phenylcarbamoyl (CH3ONa—eliminated with hot CH3OH), carbonate esters such as benzylthiocarbonyl (H2O2—CH3CO2H), nitrate esters (eliminated with Na2S, etc.), sulfonate esters (Na—Hg— Non-carboxylic acid esters such as CH3OH) are used.
The carboxy protecting group (P3) includes optionally substituted C1-6 alkyl, C2-6 alkenyl, C3-10 cycloalkyl, C3-10 cycloalkyl C1-6 alkyl, optionally substituted C6-10. Aryl, optionally substituted C7-12 aralkyl, di-C6-10 arylmethyl, tri-C6-10 arylmethyl, substituted silyl and the like are used.
The present invention also provides prodrugs of compounds (I) and (II), pharmaceutically acceptable salts and solvates thereof. All tautomers, geometric isomers and the like that are theoretically possible for the compounds of the present invention are also within the scope of the present invention.
A prodrug is a derivative of a compound of the present invention having a group that can be chemically or metabolically degraded, and is a compound that becomes a pharmaceutically active compound of the present invention by solvolysis or under physiological conditions in vivo. Methods for selecting and producing suitable prodrug derivatives are described, for example, in Design of Prodrugs, Elsevier, Amsterdam 1985.
Examples of the pharmaceutically acceptable salt of the compound of the present invention include basic salts such as alkali metal salts such as sodium salt and potassium salt; alkaline earth metal salts such as calcium salt and magnesium salt; ammonium salt; trimethylamine salt, Aliphatic amine salts such as triethylamine salt, dicyclohexylamine salt, ethanolamine salt, diethanolamine salt, triethanolamine salt, brocaine salt, meglumine salt, diethanolamine salt or ethylenediamine salt; aralkyl such as N, N-dibenzylethylenediamine or venetamine salt Amine salt: Heterocyclic aromatic amine salt such as pyridine salt, picoline salt, quinoline salt, isoquinoline salt; tetramethylammonium salt, tetraethylammonium salt, benzyltrimethylammonium salt, benzyltriethylammonium salt Quaternary ammonium salts such as benzyltributylammonium salt, methyltrioctylammonium salt and tetrabutylammonium salt; and basic amino acid salts such as arginine salt and lysine salt. Examples of the acid salt include inorganic acid salts such as hydrochloride, sulfate, nitrate, phosphate, carbonate, bicarbonate, perchlorate; acetate, propionate, lactate, maleate, Organic acid salts such as fumarate, tartrate, malate, citrate, ascorbate; sulfonates such as methanesulfonate, isethionate, benzenesulfonate, p-toluenesulfonate; Examples include acidic amino acids such as aspartate and glutamate.
Examples of the solvate of the compound of the present invention include alcohol solvates and hydrates.
The compound of the present invention can be administered orally or parenterally. If by oral administration:
The compound of the present invention is also used as a dosage form of a normal preparation, for example, a solid preparation such as a tablet, powder, granule or capsule; a liquid preparation; an oil suspension; or a liquid preparation such as a syrup or elixir. be able to. In the case of parenteral administration, the compound of the present invention can be used as an aqueous or oily suspension injection or nasal solution. In the preparation, conventional excipients, binders, lubricants, aqueous solvents, oily solvents, emulsifiers, suspending agents, preservatives, stabilizers and the like can be arbitrarily used. In addition, as an anti-HIV drug, an oral preparation is particularly preferable.
The formulations of the present invention are prepared by combining (eg, mixing) a therapeutically effective amount of a compound of the present invention with a pharmaceutically acceptable carrier or diluent. The preparation of the compound of the present invention is produced by a known method using well-known and readily available components.
The dose of the compound of the present invention varies depending on the administration method, the patient's age, weight, condition, and type of disease. For example, in the case of oral administration, about 0.05 mg to 3000 mg per adult day
May be divided and administered as needed. In the case of parenteral administration, about 0.
Administer between 01 mg and 1000 mg.

室温下、化合物１（60ｇ）をＴＨＦ250mlに溶解し、これにconc.HCl 4.8mlを滴下する。
この反応溶液を室温下にて1.5時間攪拌後、飽和NaHCO3水溶液を加えてAcOEt抽出し
た。抽出液をbrine洗浄後、無水MgSO4を用いて乾燥し、減圧下濃縮した。濃縮して得
られたオイル状物質をシリカゲルカラムクロマトグラフィー（ヘキサンー酢酸エチル系）
にて分離精製した後、溶媒を減圧下留去して白色泡状化合物２（53.1ｇ）を得た。
MS(FAB):899+(M+H+). HRMS(FAB):calcd for C48H71N2O14 899.4905 found 899.4902
Anal Calcd for C48H70N2O14(H2O)0.5:C 63.49, H 7.88, N 3.08 Found C 63.47, H 7.90, N
3.07
IR(KBr): 3503, 3066, 3033, 2976, 2938, 2878, 2831, 1752, 1732, 1706, 1629, 1497, 1455,
1406, 1380, 1334, 1292, 1255, 1165, 1120, 1076, 1002, 983, 957, 935, 895, 783, 768, 754,
699, 665, 595, 577, 517, 472(cm-1)
窒素雰囲気下、ジクロロメタン260ml にDMSO16.8mlを加えた溶液を-78℃に冷却し、
(CF3CO)2O 16.8 mlを滴下して１５分間-78℃にて攪拌した。これに化合物２（53.1ｇ）を
ジクロロメタン230mlに溶かした溶液を15分かけて滴下し、-78℃にて1.5時間攪拌した。
この反応液に-78℃下、トリエチルアミン41.2mlを滴下して更に2時間攪拌後、飽和NH4Cl
水溶液を加えてCHCl3抽出した。抽出液を無水MgSO4を用いて乾燥後、減圧下濃縮した。
この濃縮して得られたオイル状物質をシリカゲルカラムクロマトグラフィー（ヘキサンー
酢酸エチル系）にかけて分離精製し、溶媒を減圧下留去して白色泡状化合物３B（44.7ｇ）
を得た。
MS(FAB):897+(M+H+). HRMS(FAB):calcd for C48H69N2O14 897.4749 found 897.4742
Anal Calcd for C48H68N2O14(H2O)0.3:C 63.88, H 7.66, N 3.10 Found C 63.84, H 7.61, N
3.03
IR(KBr): 3513, 3417, 3066, 3033, 2977, 2938, 2877, 1748, 1705, 1497, 1455, 1406, 1380,
1333, 1292, 1254, 1169, 1115, 1069, 984, 935, 917, 892, 783, 767, 754, 738, 698, 594,
473(cm-1)

実施例２

窒素雰囲気下、THF420ｍｌに化合物３B（34.8ｇ）を溶かした溶液にピリジン16.1ｍｌ
を加えた後、氷冷下冷却し攪拌した。この溶液に氷冷下、(CCl3O)2CO 15gを小量ずつ分
けて加えた。加え終わった後、氷冷下にて15分攪拌後、室温に上げて室温下終夜攪拌し
た。反応溶液に飽和NaHCO3水溶液を注意深く加えて、AcOEt抽出した。抽出液を無水
MgSO4を用いて乾燥後、減圧下濃縮した。この濃縮して得られたオイル状物質をシリカゲ
ルカラムクロマトグラフィー（ヘキサンー酢酸エチル系）にかけて分離精製し、溶媒を減
圧下留去して白色泡状化合物3A（18.9ｇ）を得た。
MS(FAB):923+(M+H+). HRMS(FAB):calcd for C49H67N2O15 923.4541 found 923.4545
Anal Calcd for C48H68N2O14(H2O)0.3:C 63.14, H 7.25, N 3.01 Found C 63.10, H 7.22, N
2.98
IR(KBr): 3428, 3066, 3032, 2976, 2938, 2880, 1811, 1752, 1704, 1644, 1497, 1455, 1382,
1330, 1292, 1254, 1167, 1114, 1067, 990, 953, 931, 913, 782, 769, 754, 739, 698, 613,
596, 519, 457(cm-1)

ジクロロメタン10mlとメタノール2mlの混合溶液に化合物3A（1.5ｇ）を溶解し、−78℃
に冷却後、オゾンガスを2時間バブリングさせた後、窒素ガスを5分間バブリングした。
この反応溶液に−78℃下ジメチルスルフィド0.6mlを加えて攪拌した後、室温に上げて水
20mlを加え、CHCl3抽出した。ついで抽出液を無水MgSO4を用いて乾燥後、減圧下濃縮
した。濃縮液にt-BuOH 15ml, H2O 5ml, 2-Methyl-2-butene 0.8mlを加えて室温下、攪拌
する。この溶液に室温下にてNaH2PO4・2H2O 254mg, NaClO2 643mgを加えて1時間攪
拌し、氷冷下に冷却後、1N−HCl 15mlを加えてCHCl3抽出した。抽出液を無水MgSO4
を用いて乾燥後、減圧下濃縮し、ついでシリカゲルカラムクロマトグラフィー（CHCl3ー
メタノール系）にかけて分離精製し、溶媒を減圧下留去して白色泡状化合物4Aa（1.03ｇ）
を得た。
MS(FAB):963+(M+Na+).HRMS(FAB):calcd for C48H64N2O17Na1 963.4103 found
963.4106
Anal Calcd for C48H64N2O17(H2O)2 :C 59.01, H 7.01, N 2.87 Found C 58.95, H 6.76, N
2.93
IR(KBr): 3430, 3065, 3032, 2975, 2938, 2881, 1809, 1752, 1703, 1618, 1497, 1455, 1406,
1382, 1329, 1290, 1253, 1167, 1113, 1082, 1067, 992, 954, 933, 895, 826, 782, 770, 754,
698, 622, 595, 573, 518, 458(cm-1)

実施例３

窒素雰囲気下、EtOH 400ml、THF40mlの混合溶液に化合物３B（12.6ｇ）を溶解させ、
室温下にて攪拌する。これにPd(OAc)2 160mgを加え、超音波を用いて完全に溶解後、PPh3
560mg, HCO2H 1.6ml, NEt3 5.8mlを順次加える。この反応溶液の温度を上げて加熱還流
下、2時間攪拌後、再び室温に冷却する。減圧下にて溶媒を留去した後、飽和NH4Cl水溶
液を加えてAcOEt抽出し、ついで抽出液を無水MgSO4を用いて乾燥後、減圧下濃縮した。
この濃縮して得られたオイル状物質をシリカゲルカラムクロマトグラフィー（ヘキサンー
酢酸エチル系）にかけて分離精製し、溶媒を減圧下留去して白色泡状化合物5B（11.2ｇ）
を得た。
MS(FAB):857+(M+H+). HRMS(FAB):calcd for C45H65N2O14 857.4436 found 857.4438
Anal Calcd for C45H64N2O14(H2O)0.4 :C 62.54, H 7.56, N 3.24 Found C 62.49, H 7.47, N
3.17
IR(KBr): 3421, 3065, 3033, 2976, 2938, 2877, 1748, 1706, 1640, 1587, 1497, 1455, 1406,
1381, 1333, 1292, 1253, 1168, 1114, 1086, 1069, 1034, 983, 957, 936, 918, 892, 825, 783,
768, 754, 739, 698, 657, 614, 518, 472(cm-1)

窒素雰囲気下、DMF640mlに化合物5B（6.39ｇ）を溶かした溶液を攪拌して氷冷下に置
き、60％ NaH 7.46ｇを小量ずつ加える。氷冷下にて１時間攪拌後、(R)-2-Bromo-propionic
acid allyl ester 3.6gを滴下し、氷冷下にて更に30分攪拌した。この反応液に氷冷下、1N
−HCl 120ｍｌを加えてAcOEt抽出し、抽出液をbrine洗浄後、無水MgSO4を用いて乾
燥した。ついで減圧下、溶媒留去した後、シリカゲルカラムクロマトグラフィー（ヘキサ
ンー酢酸エチル系）にかけて分離精製し、溶媒を減圧下留去して白色泡状化合物6Bb（5.53
ｇ）を得た。
MS(FAB):969+(M+H+). HRMS(FAB):calcd for C51H73N2O16 969.4960 found 969.4968
Anal Calcd for C51H72N2O16 :C 63.21, H 7.49, N 2.89 Found C 63.08, H 7.52, N 3.09
IR(KBr): 3451, 3066, 3033, 2979, 2938, 2877, 1749, 1705, 1648, 1630, 1497, 1455, 1406,
1380, 1333, 1255, 1169, 1149, 1116, 1085, 1068, 983, 958, 911, 895, 783, 767, 754, 698,
614, 521, 472(cm-1)

実施例４

窒素雰囲気下、6Bb (2.05g)をTHF 100mlに溶かした溶液を氷冷下に冷却し、(CCl3)2CO
1.24gを加えた後、Pyridine 1.7mlを滴下する。滴下後、氷冷下において30分攪拌、次い
で室温下で4時間攪拌した。再び反応溶液を氷冷下に冷却し、飽和NaHCO3水溶液を注
意深く加えて、AcOEt抽出した。抽出液を無水MgSO4を用いて乾燥後、減圧下濃縮した。
濃縮後、シリカゲルカラムクロマトグラフィー（ヘキサンー酢酸エチル系）にかけて分離
精製し、溶媒を減圧下留去して白色泡状化合物6Ab（1.95ｇ）を得た。
MS(FAB):995+(M+H+). HRMS(FAB):calcd for C52H71N2O17 995.4753 found 995.4742
Anal Calcd for C51H72N2O16(H2O)0.3(CHCl3)0.08 :C 61.93, H 7.05, N 2.77, Cl 0.84 Found C
61.91, H 6.99, N 3.00, Cl 0.82
IR(KBr): 3428, 3065, 3032, 2977, 2938, 2880, 1812, 1752, 1704, 1647, 1497, 1455, 1382,
1329, 1289, 1254, 1167, 1115, 1084, 1067, 1047, 989, 952, 897, 782, 769, 754, 698, 623,
518, 472(cm-1)

窒素雰囲気下、6Ab (1.95g)をCH3CN 30mlに溶かした溶液にAcOEt 30mlを加えて氷冷
下に冷却し、Pd(PPh3)4 229mg, PPh3 104mg, pyrolidine 248μl, H2O 3mlを順次加えて、
室温下で2時間攪拌した。これに10%H3PO4 100mlを加えてAcOEt抽出した。抽出液を
brine洗浄後、無水MgSO4を用いて乾燥し、ついで減圧下にて溶媒留去した後、シリカゲ
ルカラムクロマトグラフィー（クロロホルムーメタノール系）にかけて分離精製し、溶媒
を減圧下留去して白色泡状化合物4Ab（1.14ｇ）を得た。
MS(FAB):955+(M+H+). HRMS(FAB):calcd for C49H67N2O17 955.4440 found 955.4450
Anal Calcd for C49H66N2O17(H2O)0.6 :C 60.93, H 7.01, N 2.90 Found C 60.96, H 6.82, N
2.91
IR(KBr): 3423, 3065, 3033, 2978, 2939, 2881, 1813, 1752, 1704, 1497, 1455, 1382, 1330,
1291, 1254, 1167, 1114, 1084, 1066, 1048, 991, 951, 897, 826, 782, 770, 754, 739, 698,
624, 519, 457(cm-1)

実施例５

窒素雰囲気下、4Aa (300mg)をトルエン6ｍｌに溶かした溶液にDMF 2μl, (ClCO)2 58.5
μlを加えて室温下2時間攪拌した。これに3-Phenyl-propylamine 181μlを加えて更に
室温下15分攪拌した。飽和ＮＨ4Ｃｌ水溶液を加えて、AcOEt抽出し、抽出液をbrine洗
浄後、無水MgSO4を用いて乾燥した。ついで減圧下にて溶媒留去した後、シリカゲルカ
ラムクロマトグラフィー（ヘキサンー酢酸エチル系）にかけて分離精製し、溶媒を減圧下
留去して白色泡状化合物7Aa-1（298mg）を得た。
7Aa-1（298mg）をEtOH 24mlに溶解し、Pd(OH)2/C 89mg, Acetate Buffer(0.2mol/l, pH
4.4) 6mlを加えて、常圧下において1時間攪拌しながら水素添加した。これに
HCHOaq(37%)を2.1ml加えて、更に2時間攪拌しながら水素添加後、ろ過してろ液を減
圧下濃縮した。 濃縮液に飽和NaHCO3水溶液を加えてAcOEt抽出し、抽出液を無水
MgSO4を用いて乾燥後、減圧下濃縮した。濃縮後、シリカゲルカラムクロマトグラフィー
（クロロホルムーメタノール系）にかけて分離精製し、溶媒を減圧下留去して白色泡状化
合物9Aa-1（178mg）を得た。
MS(FAB):804+(M+H+).HRMS(FAB): calcd for C42H66N3O12 804.4647 found 804.4650
IR(KBr):3433, 3061, 2973, 2936, 2878, 2785, 1809, 1751, 1716, 1671, 1536, 1495, 1455,
1380, 1321, 1284, 1259, 1232, 1166, 1110, 1078, 1048, 994, 954, 932, 892, 775, 750, 700,
628, 559, 532, 455(cm-1)
1H-NMR(CDCl3) δ(ppm) : 0.89(3H, t, J = 7.2 Hz), 1.01(3H, d, J = 6.9 Hz), 1.24(3H, d, J =
6.3 Hz), 1.26(3H, d, J = 6.9 Hz), 1.27(3H, d, J = 7.5 Hz), 1.37(3H, d, J = 6.9 Hz), 1.38(3H,
s), 1.56(3H, s), 1.54-1.94(8H, m), 2.31(6H, s), 2.55(2H, m), 2.66(2H, t, J = 8.1 Hz),
2.69(3H, s), 3.02(1H, quintet, J = 7.5 Hz), 3.16-3.28(2H, m), 3.32-3.46(1H, m), 3.48-
3.74(2H, m), 3.83(1H, q, J = 6.9 Hz), 4.22(1H, d, J = 7.5 Hz), 4.31(1H, d, J = 7.2 Hz),
4.45(2H, s), 4.82(1H, s), 5.00(1H, dd, J = 2.4 and 9.9 Hz), 6.90(1H, brt, J = 5.4 Hz),
7.12-7.30(5H, m)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 14.3, 15.4, 15.6, 18.8, 19.9, 21.1, 22.3, 26.3, 28.5,
30.9, 33.1, 38.0, 38.8, 40.1, 47.6, 49.8, 51.0, 65.9, 69.3, 70.2, 73.0, 76.1, 78.4, 78.6, 82.3,
84.5, 103.6, 125.7, 128.3, 128.4, 141.5, 153.8, 167.5, 169.2, 170.3, 203.9

実施例６

窒素雰囲気下、4Ab (2.0g)をトルエン42ｍｌに溶かした溶液にDMF 16μl, (ClCO)2 220
μlを加えて室温下3.5時間攪拌した。これに3-Quinoxalin-6-yl-propylamine 1.56gをＤ
ＭＦ5mlに溶かした溶液を加えて更に室温下20分攪拌した。飽和ＮＨ4Ｃｌ水溶液を加え
て、AcOEt抽出し、抽出液をbrine洗浄後、無水MgSO4を用いて乾燥した。ついで減圧
下にて溶媒留去した後、シリカゲルカラムクロマトグラフィー（ヘキサンー酢酸エチルー
アセトニトリル系）にかけて分離精製し、溶媒を減圧下留去して白色泡状化合物7Ab-2
（1.97g）を得た。
窒素雰囲気下、7Ab-2（1.96g）をCH2Cl2 17ｍｌに溶かした溶液を氷冷下に冷却し、TMSI
1.24mlを加えて20分間氷冷下にて攪拌した。これにAlCl3 (1.16g), anisole 11mlをCH2Cl2
11ｍｌに溶かした溶液を更に加えて1時間氷冷下にて攪拌した。反応液に氷冷下、H2O
1.74mlを注意深く加えると、沈殿物が生成してくる。ヘキサン35ｍｌを加えてデカンテ
ーション。上澄み液を除去して、ヘキサン35ｍｌを更に加えてデカンテーション。上澄み
液を除去後、沈殿物にCHCl3 120ｍｌ、MeOH 30ml, 飽和NaHCO3水溶液を加えてCHCl3
抽出し、抽出液を無水MgSO4を用いて乾燥後、減圧下濃縮した。濃縮後、MeOH 17ml, 98%
HCOOH (134μl), HCHOaq(37%)を0.9ml加え、75℃のオイルバス下において1.5時間攪
拌した。室温に冷却して飽和NaHCO3水溶液を加え、AcOEt抽出し、抽出液をbrine洗
浄後、無水MgSO4を用いて乾燥した。ついで減圧下にて溶媒留去した後、シリカゲルカ
ラムクロマトグラフィー（クロロホルムーメタノール系）にかけて分離精製し、溶媒を減
圧下留去して白色泡状化合物9Ab-2（1.51g）を得た。
Anal Calcd for C45H67N5O12 :C 62.12,H7.76,N8.05 Found C 61.79,H7.72,N7.94
MS(FAB):870+(M+H+). HRMS(FAB): calcd for C45H68N5O12 870.4864 found 870.4873
IR(KBr):3435, 2974, 2937, 2878, 2784, 1811, 1751, 1716, 1673, 1530, 1499, 1455, 1367,
1322, 1284, 1257, 1234, 1218, 1167, 1141, 1109, 1082, 1047, 1005, 992, 954, 931, 897,
866, 832, 773, 755, 693, 666, 631, 573, 458, 408(cm-1)
1H-NMR(CDCl3) δ(ppm) : 0.85(3H, t, J = 7.2 Hz), 1.00(3H, d, J = 6.9 Hz), 1.21(3H, d, J =
6.0 Hz), 1.25(3H, d, J = 7.5 Hz), 1.27(3H, d, J = 7.2 Hz), 1.36(3H, d, J = 6.9 Hz), 1.39(3H,
s), 1.44(3H, d, J = 6.9 Hz), 1.56(3H, s), 1.54-1.74(4H, m), 1.87(2H, m), 2.03(2H, m),
2.26(6H, s), 2.45(1H, m), 2.55(1H, q, J =7.2 Hz), 2.67(3H, s), 2.92(2H, t, J = 7.5 Hz),
3.01(1H, quintet, J = 7.5 Hz), 3.10-3.22(2H, m), 3.46-3.58(2H, m), 3.64-3.75(1H, m),
3.82(1H, q, J = 6.9 Hz), 4.21(1H, d, J = 8.4 Hz), 4.29(1H, d, J = 7.2 Hz), 4.49(1H, q, J =
6.9 Hz), 4.84(1H, s), 4.99(1H, dd, J = 2.7 and 10.5 Hz), 7.20(1H, brt, J = 5.7 Hz),
7.70(1H, dd, J = 1.8 and 8.7 Hz), 7.91(1H, d, J = 1.8 Hz ), 8.01(1H, d, J = 8.7 Hz),
8.27(1H, d, J = 1.8 Hz), 8.30(1H, d, J = 1.8 Hz)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.6, 15.8, 18.9, 19.9, 21.1, 22.3, 26.2,
28.3, 30.5, 33.1, 33.4, 37.9, 39.0, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 76.0, 78.4, 78.5,
82.4, 84.6, 103.7, 127.8, 129.1, 131.6, 141.8, 143.2, 144.1, 144.6, 144.8, 153.8, 166.4,
169.3, 172.2, 203.9

実施例７

窒素雰囲気下、4Ab (383mg)をCH2Cl2 9ｍｌに溶かした溶液にHOBt 81mg, WSCD・HCl
115mgを加えて室温下1時間攪拌した。これに3-Quinoxalin-5-yl-propylamine 112mg
をCH2Cl2 3mlに溶かした溶液を加えて更に室温下2時間攪拌した。飽和ＮＨ4Ｃｌ水溶液
を加えて、AcOEt抽出し、抽出液をbrine洗浄後、無水MgSO4を用いて乾燥した。つい
で減圧下にて溶媒留去した後、シリカゲルカラムクロマトグラフィー（ヘキサンー酢酸エ
チルーアセトニトリル系）にかけて分離精製し、溶媒を減圧下留去して白色泡状化合物
7Ab-3（450mg）を得た。次に実施例6で7Ab-2から9Ab-2を合成した方法と同様にして、
7Ab-3（417mg）から9Ab-3(270mg) を得た。
MS(FAB):870+(M+H+). HRMS(FAB): calcd for C45H68N5O12 870.4864 found 870.4867
IR(KBr):3436, 2973, 2937, 2878, 2784, 1811, 1751, 1716, 1674, 1577, 1528, 1490, 1456,
1379, 1361, 1322, 1283, 1257, 1233, 1167, 1142, 1109, 1082, 1047, 1005, 993, 952, 931,
900, 865, 835, 801, 771, 682, 632, 573, 533, 453, 431(cm-1)
1H-NMR(CDCl3) δ(ppm) : 0.87(3H, t, J = 7.2 Hz), 0.99(3H, d, J = 6.6 Hz), 1.20(3H, d, J =
6.0 Hz), 1.26(3H, d, J = 6.3 Hz), 1.27(3H, d, J = 7.5 Hz), 1.36(3H, d, J = 7.2 Hz), 1.39(3H,
s), 1.45(3H, d, J = 6.9 Hz), 1.55(3H, s), 1.55-1.74(4H, m), 1.87(1H, m), 1.97-2.08(3H, m),
2.26(6H, s), 2.44(1H, m), 2.54(1H, q, J = 7.2 Hz), 2.66(3H, s), 3.01(1H, m), 3.13-3.25(2H,
m), 3.30(2H, t, J = 7.5 Hz), 3.43-3.58(2H, m), 3.63-3.74(1H, m), 3.81(1H, q, J = 6.3 Hz),
4.20(1H, d, J = 8.1 Hz), 4.28(1H, d, J = 7.2 Hz), 4.52(1H, q, J = 6.9 Hz), 4.82(1H, s),
4.94(1H, dd, J = 2.7 and 10.2 Hz), 7.07(1H, brt, J = 5.7 Hz), 7.67(1H, dd, J = 2.7 and 7.2
Hz), 7.70(1H, dd, J = 6.9 and 7.2 Hz), 7.94(1H, dd, J = 2.7 and 6.9 Hz), 8.82(1H, d, J =
1.8 Hz), 8.85(1H, d, J = 1.8 Hz)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.2, 15.3, 15.7, 16.1, 18.9, 19.9, 21.1, 22.2, 26.3,
28.0, 28.2, 30.3, 33.0, 37.9, 39.0, 40.2, 47.7, 49.7, 51.0, 65.8, 69.5, 70.3, 75.9, 78.4, 78.5,
78.6, 82.4, 84.5, 103.8, 127.4, 129.3, 129.8, 141.2, 141.7, 143.1, 143.7, 144.5, 153.8,
166.3, 169.1, 172.0, 203.9

実施例８

窒素雰囲気下、5B (300mg)をTHF 6ｍｌに溶かした溶液を氷冷下に冷却し、NaH 30mg
を加えて20分間攪拌した。これにBromo-acetic acid 3-phenyl-propyl ester 105mgを
THF 1mlに溶かした溶液を滴下し、室温に上げて1時間攪拌した後、加熱還流下5時間
攪拌した。室温に冷却後、飽和ＮＨ4Ｃｌ水溶液を加えて、AcOEt抽出し、抽出液をbrine
洗浄後、無水MgSO4を用いて乾燥した。ついで減圧下にて溶媒留去した後、シリカゲル
カラムクロマトグラフィー（ヘキサンー酢酸エチル系）にかけて分離精製し、溶媒を減圧
下留去して白色泡状化合物8Aa-1（51mg）を得た。次に実施例5で7Aa-1から9Aa-1を
合成した方法と同様にして、8Aa-1（51mg）から10Aa-1(12.4mg) を得た。
MS(SI):805+(M+H+).HRMS(SI):calcd for C42H65N2O13 805.4483 found 805.4486
IR(KBr):3447, 2924, 2877, 2851, 2785, 1810, 1752, 1653, 1636, 1628, 1604, 1569, 1560,
1542, 1508, 1497, 1456, 1381, 1362, 1323, 1304, 1284, 1258, 1167, 1142, 1108, 1084,
1047, 1004, 993, 953, 932, 891, 860, 834, 800, 773, 748, 700, 632, 567, 529, 512, 455,
432, 411(cm-1)
1H-NMR(CDCl3) δ(ppm) : 0.89(3H, t, J = 7.2 Hz), 1.03(3H, d, J = 6.9 Hz), 1.23(3H, d, J =
6.0 Hz), 1.25(3H, d, J = 6.9 Hz), 1.27(3H, d, J = 7.8 Hz), 1.37(3H, d, J = 6.9 Hz), 1.42(3H,
s), 1.54(3H, s), 1.54-1.76(4H, m), 1.82-2.05(4H, m), 2.27(6H, s), 2.50(2H, m), 2.69(2H, t,
J = 7.8 Hz), 2.72(3H, s), 3.05(1H, quintet, J = 7.8 Hz), 3.19(1H, dd, J = 7.2 and 9.9 Hz),
3.48-3.74(2H, m), 3.83(1H, q, J = 6.9 Hz), 4.16(2H, t, J = 6.6 Hz), 4.19(1H, d, J = 7.8 Hz),
4.30(1H, d, J = 7.2 Hz), 4.54 and 4.67(2H, ABq, J = 16.5 Hz), 4.77(1H, s), 5.02(1H, dd, J
= 2.7 and 9.6 Hz), 7.12-7.32(5H, m)
13C-NMR(CDCl3):δ(ppm)10.4, 13.2, 14.3, 15.3, 15.8, 18.8, 19.7, 21.1, 22.5, 26.7, 28.2,
29.7, 30.1, 32.1, 38.3, 40.2, 47.8, 49.7, 51.1, 64.0, 65.9, 69.5, 70.3, 70.5, 76.4, 78.5, 79.5,
82.5, 84.8, 103.8, 126.0, 128.4, 128.5, 141.1, 154.3, 166.0, 169.1, 170.1, 204.1

実施例９

窒素雰囲気下、4Aa (200mg)をCH3CN 6ｍｌに溶かした溶液に、NEt3 45μl,
DPPA(Diphenylphosphoryl azide) 64μlを加えて室温で5時間攪拌した。さらに50℃に
昇温して3.5時間攪拌した後に室温に冷却し、ジメチルアミン水溶液(10eq)を加えて室温
下で10分間攪拌した。次に飽和ＮＨ4Ｃｌ水溶液を加えて、AcOEt抽出し、抽出液をbrine
洗浄後、無水MgSO4を用いて乾燥した。ついで減圧下にて溶媒留去した後、シリカゲル
カラムクロマトグラフィー（ヘキサンー酢酸エチル系）にかけて分離精製し、溶媒を減圧
下留去して白色泡状化合物11Aa-1（119mg）を得た。次に実施例5で7Aa-1から9Aa-1
を合成した方法と同様にして、11Aa-1（86mg）から12Aa-1(34mg) を得た。
MS(FAB):729+(M+H+). HRMS(FAB):calcd for C35H61N4O12 729.4286 found 729.4285
IR(KBr): 3416, 2972, 2938, 2879, 2783, 1809, 1752, 1669, 1555, 1457, 1380, 1303, 1284,
1257, 1234, 1166, 1110, 1078, 1048, 987, 932, 893, 776, 695, 616, 529, 455(cm-1)
1H-NMR(CDCl3) δ(ppm) : 0.90(3H, t, J = 7.5 Hz), 0.96(3H, d, J = 6.9 Hz), 1.24(6H, d, J =
6.3 Hz), 1.26(3H, d, J = 7.2 Hz), 1.37(3H, d, J = 6.9 Hz), 1.39(3H, s), 1.56(3H, s), 1.54-
1.72(4H, m), 1.90(2H, m), 2.29(6H, s), 2.51(2H, m), 2.60(3H, s), 2.87(6H, s), 2.86-
3.06(2H, m), 3.20(1H, dd, J = 7.5 and 10.2 Hz), 3.48-3.84(4H, m), 3.83(1H, q, J = 6.9 Hz),
4.18(1H, d, J = 8.4 Hz), 4.27(1H, d, J = 6.9 Hz), 4.80(1H, s), 4.93(1H, dd, J = 5.4 and
10.8 Hz), 5.03(1H, dd, J = 2.7 and 10.5 Hz), 5.34(1H, dd, J = 8.4 and 10.8 Hz), 6.01(1H,
dd, J = 5.4 and 8.4Hz)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 14.2, 15.4, 15.9, 18.8, 19.9, 21.2, 22.3, 26.4, 28.2,
32.9, 35.9, 38.1, 40.1, 47.9, 49.1, 51.0, 65.9, 69.4, 70.2, 74.0, 76.0, 78.5, 79.4, 82.9, 84.7,
103.8, 154.5, 157.4, 165.0, 169.2, 203.8

実施例10

酢酸エチル125mlとメタノール6.3mlの混合溶液に化合物3A（3.86ｇ）を溶解し、−78℃
に冷却後、オゾンガスを0.5時間バブリングさせた後、窒素ガスを5分間バブリングした。
この反応溶液に−78℃下ジメチルスルフィド5mlを加えて攪拌した後、室温に上げて更に
1.5時間攪拌した。これに水を加えて、AcOEt抽出し,抽出液を無水Na2SO4を用いて乾燥
後、減圧下濃縮した。濃縮液にEtOH 40mlを加えて氷冷下冷却後, NaBH4 47.3mgを加
えて氷冷下0.5時間攪拌した。これに10%H3PO4水溶液をゆっくり加えた後、AcOEt抽
出した。抽出液を飽和NaHCO3水溶液及びbrineで洗浄後、無水Na2SO4を用いて乾燥、
減圧下濃縮した。ついでシリカゲルカラムクロマトグラフィー（トルエンー酢酸エチル系）
にかけて分離精製し、溶媒を減圧下留去して白色泡状化合物13A（3.19ｇ）を得た。
MS(FAB):927+(M+H+). HRMS(FAB):calcd for C48H67N2O16 927.4491 found 927.4485
Anal Calcd for C48H66N2O16(H2O)0.3:C 61.83, H 7.20, N 3.00 Found C 61.78, H 7.10, N
3.06
IR(KBr):3444, 3064, 3033, 2973, 2938, 2879, 1812, 1751, 1702, 1633, 1587, 1496, 1455,
1382, 1330, 1290, 1253, 1166, 1114, 1066, 991, 952, 933, 906, 827, 782, 769, 755, 740,
698, 622, 593, 563, 518, 455, 403(cm-1)

窒素雰囲気下、13A (513mg)をAcOEt 5mlに溶かした溶液を氷冷下に冷却及び攪拌し、
NEt3 130μl, MsCl 390μlを加えて氷冷下0.5時間攪拌した。これに10%H3PO4水溶液を
加えてAcOEt抽出。抽出液を飽和NaHCO3水溶液及びbrineで洗浄後、無水Na2SO4を
用いて乾燥、減圧下濃縮して白色泡状化合物（585mg）を得た。続いてこの白色泡状化合
物（585mg）をDMF5mlに溶解した後、NaN3 (181mg)を加えて80℃にて2.5時間攪拌
した。室温に冷却後、10%H3PO4水溶液を加えてAcOEt抽出。抽出液を飽和NaHCO3水
溶液及びbrineで洗浄後、無水Na2SO4を用いて乾燥、減圧下濃縮した。ついでシリカゲ
ルカラムクロマトグラフィー（トルエンー酢酸エチル系）にかけて分離精製し、溶媒を減
圧下留去して白色泡状化合物14A（357mg）を得た。
MS(FAB):952+(M+H+). HRMS(FAB):calcd for C48H66N5O15 952.4555 found 952.4561
Anal Calcd for C48H65N5O15:C 60.56, H 6.88, N 7.36 Found C 60.39, H 6.86, N 7.40
IR(KBr):3424, 3064, 3033, 2975, 2938, 2879, 2103, 1812, 1752, 1702, 1633, 1496, 1455,
1382, 1330, 1288, 1255, 1166, 1114, 1068, 1047, 1004, 991, 952, 933, 906, 827, 782, 769,
755, 738, 698, 622, 518, 457(cm-1)

実施例11

THF 6mlに化合物14A（338mｇ）を溶解し、PPh3 279mｇ, H2O 32μlを加えて終夜室
温下で攪拌した。これを氷冷下に冷却後、3-Phenyl-propionyl chloride 106μl, NEt3 148
μを加えて室温下0.5時間攪拌した。飽和NaHCO3水溶液を加えてAcOEt抽出。抽出液
を飽和NaHCO3水溶液及びbrineで洗浄後、無水Na2SO4を用いて乾燥、減圧下濃縮した。
ついでシリカゲルカラムクロマトグラフィー（トルエンー酢酸エチル系）にかけて分離精
製し、溶媒を減圧下留去して白色泡状化合物15Aa-1（368mg）を得た。次に実施例5で
7Aa-1から9Aa-1を合成した方法と同様にして、15Aa-1（346mg）から16Aa-1(211mg) を
得た。
MS(FAB):804+(M+H+). HRMS(FAB):calcd for C42H66N3O12 804.4646 found 804.4642
IR(CHCl3):3392, 3022, 2970, 2934, 2872, 1805, 1752, 1716, 1651, 1515, 1454, 1382,
1361, 1305, 1283, 1256, 1228, 1166, 1139, 1108, 1073, 1045, 1006, 990, 951, 929,
908(cm-1)
1H-NMR(CDCl3) δ(ppm) : 0.84(3H, t, J = 7.2 Hz), 0.97(3H, d, J = 6.9 Hz), 1.22(3H, d, J =
6.3 Hz), 1.24(3H, d, J = 7.2 Hz), 1.27(3H, d, J = 7.5 Hz), 1.37(3H, d, J = 7.2 Hz), 1.38(3H,
s), 1.55(3H, s), 1.54-1.70(4H, m), 1.85(2H, m), 2.26(6H, s), 2.51(2H, m), 2.64(2H, t, J =
7.2 Hz), 2.65(3H, s), 2.92-3.04(4H, m), 3.18(1H, dd, J = 7.2 and 10.2), 3.30-3.78(4H, m),
3.82(1H, q, J = 6.9 Hz), 4.05(2H, t, J = 3.6 Hz), 4.21(1H, d, J = 8.1 Hz), 4.29(1H, d, J =
7.2 Hz), 4.79(1H, s), 4.95(1H, dd, J = 2.4 and 9.9 Hz), 6.80(1H, brs), 7.12-7.30(5H, m)
13C-NMR(CDCl3):δ(ppm)10.0, 12.9, 14.0, 15.5, 18.5, 19.6, 21.0, 22.0, 25.7, 28.0, 31.5,
32.6, 37.2, 37.9, 40.0, 41.6, 47.5, 49.3, 50.8, 65.6, 69.3, 70.1, 71.6, 76.0, 78.2, 78.7, 82.9,
84.4, 103.6, 125.6, 128.0, 128.2, 141.1, 153.6, 165.5, 168.8, 172.4, 203.7

実施例12

THF 7mlに化合物14A（304mｇ）を溶解し、PPh3 260mｇ, H2O 30μlを加えて終夜室
温下で攪拌した。これを氷冷下に冷却後、あらかじめ調製しておいた1-Imidazol-1-yl-3-
quinoxalin-6-yl-propane-1-one溶液（CH3CN 3mlに3-Quinoxalin-6-yl-propionic acid
173mg、及び1,1'-Carbonyldiimidazole 107mgを加え、室温下で4時間攪拌して調製）
を加えて室温下40分間攪拌した。飽和NaHCO3水溶液を加えてAcOEt抽出。抽出液を
飽和NaHCO3水溶液及びbrineで洗浄後、無水Na2SO4を用いて乾燥、減圧下濃縮した。
ついでシリカゲルカラムクロマトグラフィー（クロロホルムーメタノール系）にかけて分
離精製し、溶媒を減圧下留去して白色泡状化合物15Aa-2（366mg）を得た。次に実施例6
で7Ab-2から9Ab-2を合成した方法と同様にして、15Aa-2（232mg）から16Aa-2(136mg)
を得た。
MS(FAB):856+(M+H+). HRMS(FAB):calcd for C44H66N5O12 856.4708 found 856.4713
Anal Calcd for C44H65N5O12(H2O)1.2:C 60.22, H 7.74, N 7.98 Found C 60.17, H 7.50, N
7.82
IR(KBr):3397, 2972, 2937, 2878, 2784, 1809, 1751, 1716, 1670, 1500, 1455, 1380, 1322,
1305, 1284, 1258, 1233, 1219, 1167, 1141, 1109, 1075, 1046, 1005, 992, 954, 930, 913,
866, 832, 799, 769, 754, 693, 666, 622, 580, 531, 512, 456, 407(cm-1)
1H-NMR(CDCl3) δ(ppm) : 0.77(3H, t, J = 7.5 Hz), 0.96(3H, d, J = 7.2 Hz), 1.20(3H, d, J =
6.9 Hz), 1.24(3H, d, J = 6.3 Hz), 1.26(3H, d, J = 7.8 Hz), 1.36(3H, d, J = 6.6 Hz), 1.38(3H,
s), 1.54(3H, s), 1.50-1.90(6H, m), 2.28(6H, s), 2.42-2.55(2H, m), 2.65(3H, s), 2.81(2H, t, J
= 7.5 Hz), 3.00(1H, quintet, J = 7.8 Hz), 3.19(1H, dd, J = 7.5 and 10.2 Hz), 3.24(2H, dt,
J = 3.6 and 8.1 Hz), 3.32-3.43(1H, m), 3.48-3.76(3H, m), 3.82(1H, q, J = 6.6 Hz), 4.07(2H,
t, J = 3.6 Hz), 4.21(1H, d, J = 7.8 Hz), 4.29(1H, d, J = 7.5 Hz), 4.79(1H, s), 4.95(1H, dd, J
= 2.7 and 10.2 Hz), 6.97(1H, brs), 7.75(1H, dd, J = 1.8 and 8.7 Hz), 7.97(1H, d, J = 1.8
Hz ), 8.00(1H, d, J = 8.7 Hz), 8.76(1H, d, J = 1.8 Hz), 8.79(1H, d, J = 1.8 Hz)
13C-NMR(CDCl3):δ(ppm)9.9, 12.9, 14.1, 15.4, 15.5, 18.5, 19.7, 21.0, 22.0, 25.7, 28.0, 31.5,
32.6, 36.3, 37.9, 40.0, 41.8, 47.5, 49.4, 50.8, 65.7, 69.3, 70.1, 71.6, 76.0, 78.2, 78.7, 82.9,
84.5, 103.6, 127.8, 128.8, 131.7, 141.6, 143.0, 143.9, 144.0, 144.6, 153.7, 165.7, 169.0,
172.0, 203.7

実施例１３

THF 8mlに化合物14A（415mｇ）を溶解し、PPh3 344mｇ, H2O 39μlを加えて終夜室
温下で攪拌した。これを氷冷下に冷却後、NEt3 182μl, trans-β-styrenesulfonyl chloride
176mgを加えて室温下20分間攪拌した。10%H3PO4水溶液を加えてAcOEt抽出。抽出
液を飽和NaHCO3水溶液及びbrineで洗浄後、無水Na2SO4を用いて乾燥、減圧下濃縮し
た。ついでシリカゲルカラムクロマトグラフィー（トルエンー酢酸エチル系）にかけて分
離精製し、溶媒を減圧下留去して白色泡状化合物18Aa-1（275mg）を得た。次に実施例5
で7Aa-1から9Aa-1を合成した方法と同様にして、18Aa-1（246mg）から19Aa-1(74mg)
を得た。
MS(FAB):840+(M+H+). HRMS(FAB):calcd for C41H66N3O13S1 840.4316 found 840.4316
IR(CHCl3):3020, 2970, 2934, 2872, 1804, 1752, 1714, 1454, 1381, 1361, 1323, 1281,
1232, 1229, 1161, 1108, 1071, 1046, 1006, 988, 952(cm-1)
1H-NMR(CDCl3) δ(ppm) : 0.89(3H, t, J = 7.2 Hz), 0.97(3H, d, J = 6.9 Hz), 1.20(3H, d, J =
6.9 Hz), 1.24(3H, d, J = 6.9 Hz), 1.27(3H, d, J = 9.0 Hz), 1.37(3H, d, J = 7.2 Hz), 1.38(3H,
s), 1.55(3H, s), 1.54-1.74(4H, m), 1.90(2H, m), 2.27(6H, s), 2.40-2.59(2H, m), 2.71(3H, s),
3.03(1H, quintet, J = 7.8 Hz), 3.12-3.21(3H, m), 3.36-3.70(7H, m), 3.83(1H, q, J = 6.9
Hz), 4.10(2H, t, J = 4.2 Hz), 4.22(1H, d, J = 7.8 Hz), 4.30(1H, d, J = 7.2 Hz), 4.79(1H, s),
5.05(1H, dd, J = 2.7 and 10.2 Hz), 5.35(1H, brt, J = 6.9 Hz), 7.21-7.34(5H, m)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.2, 15.5, 18.6, 19.7, 21.1, 22.2, 25.9, 28.1, 29.8,
32.9, 38.1, 40.1, 44.2, 47.5, 49.6, 50.9, 54.2, 65.7, 69.4, 70.2, 76.3, 78.2, 78.8, 82.8, 84.5,
103.6, 126.5, 128.3, 128.6, 138.2, 153.7, 166.1, 168.9, 203.9

実施例１４

実施例5で7Aa-1から9Aa-1を合成した方法と同様にして、4Aa（350mg）から20Aa(58mg)
を得た。
MS(SI):687+(M+H+).HRMS(SI):calcd for C33H55N2O13 687.3700 found 687.3698
IR(KBr):3428, 2973, 2936, 2879, 2855, 1806, 1750, 1716, 1601, 1457, 1381, 1318, 1285,
1235, 1165, 1109, 1081, 1048, 1005, 994, 954, 934, 893, 774, 697, 612, 499, 428(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.2, 14.3, 15.4, 16.0, 18.6, 19.8, 20.9, 22.4, 26.5, 29.4,
33.2, 38.3, 39.7, 47.9, 49.6, 51.1, 57.9, 66.1, 68.3, 69.6, 76.4, 78.5, 79.7, 83.2, 85.1, 103.1,
154.7, 165.3, 169.3, 177.1, 204.1

実施例１５
中間体化合物の物性を示す。
I ( 4 )
4Ac

MS(FAB):955+(M+H+). HRMS(FAB):calcd for C49H67N2O17 955.4440 found 955.4442
Anal Calcd for C49H66N2O17(H2O)1.4 :C 60.04, H 7.07, N 2.86. Found: C 60.08, H 6.73, N
2.86.
IR(KBr): 3429, 3065, 3033, 2977, 2939, 2881, 1812, 1752, 1704, 1587, 1497, 1455, 1382,
1331, 1289, 1254, 1166, 1113, 1083, 1068, 1048, 1003, 953, 899, 826, 782, 769, 755, 739,
698, 624, 595, 575, 518, 458(cm-1)

4Ad

MS(FAB):969+(M+H+). HRMS(FAB):calcd for C50H69N2O17 969.4596 found 969.4603
Anal Calcd for C50H68N2O17(H2O)0.5 :C 61.40, H 7.11, N 2.86. Found: C 61.37, H 7.10, N
2.87.
IR(KBr): 3422, 3065, 3033, 2975, 2938, 2880, 1813, 1752, 1704, 1497, 1456, 1383, 1330,
1291, 1254, 1167, 1114, 1083, 1066, 989, 953, 934, 909, 826, 782, 769, 754, 739, 698,
625, 595, 576, 518, 457(cm-1)

4Ae

MS(FAB):969+(M+H+). HRMS(FAB):calcd for C50H69N2O17 969.4596 found 969.4614
Anal Calcd for C50H68N2O17(H2O)0.8 :C 61.06, H 7.13, N 2.85. Found: C 61.04, H 6.98, N
2.87.
IR(KBr): 3428, 3065, 3032, 2975, 2938, 2880, 1811, 1752, 1704, 1587, 1497, 1455, 1382,
1330, 1291, 1253, 1167, 1113, 1083, 1066, 989, 954, 934, 910, 782, 769, 754, 739, 698,
625, 518, 457(cm-1)

4Af

MS(FAB):983+(M+H+). HRMS(FAB):calcd for C51H71N2O17 983.4753 found 983.4745
IR(KBr): 3429, 3065, 3033, 2973, 2938, 2879, 1812, 1752, 1705, 1497, 1456, 1383, 1330,
1291, 1254, 1167, 1114, 1067, 990, 933, 913, 782, 769, 754, 739, 698(cm-1)

4Ag

MS(FAB):983+(M+H+). HRMS(FAB):calcd for C51H71N2O17 983.4753 found 983.4750
IR(KBr): 3427, 3065, 3033, 2973, 2938, 2879, 1812, 1752, 1705, 1497, 1455, 1382, 1330,
1291, 1254, 1168, 1114, 1067, 1049, 991, 933, 912, 782, 769, 754, 697, 533, 516,
457(cm-1)

実施例１６
前記実施例に準じて以下の化合物を合成した。

II ( 7 )
I-1

MS(SI):686+(M+H+).HRMS(SI):calcd for C33H55N3O12 686.3860 found 686.3860
IR(KBr):3451, 2974, 2938, 2880, 2786, 1810, 1751, 1689, 1632, 1591, 1457, 1380, 1324,
1284, 1257, 1231, 1166, 1110, 1078, 1048, 994, 954, 933, 889, 834, 776, 695, 618, 531,
457(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 14.3, 15.3, 15.5, 18.8, 19.9, 21.1, 22.3, 26.4, 28.3,
33.2, 38.0, 40.1, 47.5, 49.7, 51.0, 65.8, 69.4, 70.2, 72.7, 76.1, 78.4, 78.5, 82.3, 84.7, 103.6,
153.9, 167.5, 169.2, 173.0, 204.0

I-2

MS(FAB):714+(M+H+).HRMS(FAB):calcd for C35H60N3O12 714.4177 found 714.4173
IR(KBr):3435, 2973, 2937, 2879, 2786, 1809, 1752, 1716, 1654, 1456, 1379, 1324, 1283,
1260, 1229, 1166, 1110, 1079, 1049, 994, 954, 932, 892, 834, 776, 692, 623, 581, 529,
454(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.0, 14.2, 15.3, 15.7, 18.7, 19.7, 21.1, 22.3, 26.4, 28.2,
33.0, 35.3, 36.6, 38.2, 40.1, 47.7, 49.6, 51.0, 65.7, 69.3, 70.2, 71.1, 76.2, 78.4, 79.2, 82.6,
84.6, 103.6, 154.3, 165.6, 168.8, 169.0, 203.9

I-3

MS(FAB):818+(M+H+).HRMS(FAB):calcd for C43H68N3O12 818.4803 found 818.4801
IR(KBr):3435, 2973, 2937, 2879, 2786, 1809, 1752, 1716, 1654, 1456, 1379, 1324, 1283,
1260, 1229, 1166, 1110, 1079, 1049, 994, 954, 932, 892, 834, 776, 692, 623, 581, 529,
454(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 12.7, 14.1, 15.1, 15.5, 18.6, 19.7, 21.0, 22.1, 26.1, 28.0,
28.5, 28.9, 32.9, 35.2, 37.8, 38.7, 40.0, 47.4, 49.6, 50.8, 65.6, 69.3, 70.0, 72.7, 75.9, 78.2,
78.5, 82.1, 84.4, 103.5, 125.4, 128.0, 128.2, 142.1, 153.6, 167.3, 169.0, 170.0, 203.7
I-4

MS(FAB):762+(M+H+).HRMS(FAB): calcd for C39H60N3O12 762.4177 found 762.4174
IR(KBr):3413, 3361, 2972, 2936, 2879, 2786, 1810, 1751, 1714, 1685, 1636, 1600, 1536,
1499, 1456, 1444, 1379, 1361, 1320, 1284, 1256, 1235, 1167, 1141, 1109, 1078, 1047,
1006, 993, 951, 932, 892, 858, 835, 756, 695, 635, 618, 580, 565, 507, 457, 426(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.0, 14.3, 15.5, 15.6, 18.8, 19.9, 21.1, 22.3, 26.5, 28.3,
33.2, 38.1, 40.1, 47.6, 49.7, 51.0, 65.8, 69.4, 70.2, 73.5, 76.1, 78.4, 78.6, 82.3, 84.6, 103.7,
120.1, 124.3, 128.9, 137.3, 153.9, 168.4, 168.6, 169.1, 203.8

I-5

MS(FAB):790+(M+H+).HRMS(FAB): calcd for C41H64N3O12 790.4490 found 790.4492
IR(KBr):3432, 3062, 2973, 2937, 2879, 2784, 1810, 1751, 1716, 1675, 1604, 1531, 1496,
1455, 1380, 1363, 1322, 1305, 1284, 1257, 1234, 1166, 1141, 1110, 1078, 1047, 1004,
993, 954, 931, 894, 835, 773, 752, 700, 630, 570, 532, 457(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 14.2, 15.3, 15.6, 18.8, 19.8, 21.1, 22.3, 26.3, 28.3,
33.1, 35.6, 38.0, 40.1, 40.2, 47.6, 49.6, 51.0, 65.8, 69.4, 70.2, 72.9, 76.1, 78.3, 78.6, 82.3,
84.6, 103.7, 126.2, 128.4, 128.7, 138.9, 153.9, 167.4, 169.2, 170.1, 203.9

I-6

MS(FAB):804+(M+H+).HRMS(FAB): calcd for C42H66N3O12 804.4647 found 804.4650
IR(KBr):3433, 3061, 2973, 2936, 2878, 2785, 1809, 1751, 1716, 1671, 1536, 1495, 1455,
1380, 1321, 1284, 1259, 1232, 1166, 1110, 1078, 1048, 994, 954, 932, 892, 775, 750, 700,
628, 559, 532, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 14.3, 15.4, 15.6, 18.8, 19.9, 21.1, 22.3, 26.3, 28.5,
30.9, 33.1, 38.0, 38.8, 40.1, 47.6, 49.8, 51.0, 65.9, 69.3, 70.2, 73.0, 76.1, 78.4, 78.6, 82.3,
84.5, 103.6, 125.7, 128.3, 128.4, 141.5, 153.8, 167.5, 169.2, 170.3, 203.9

I-7

MS(FAB):729+(M+H+).HRMS(FAB): calcd for C35H61N4O12 729.4286 found 729.4282
IR(KBr):3434, 2973, 2938, 2879, 2783, 1811, 1752, 1690, 1637, 1527, 1456, 1381, 1362,
1323, 1304, 1284, 1258, 1233, 1219, 1166, 1142, 1109, 1080, 1048, 1005, 993, 953, 932,
891, 860, 835, 774, 694, 627, 581, 563, 532, 456(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.2, 15.4, 15.6, 18.9, 19.9, 21.1, 22.2, 26.4, 28.4,
33.1, 38.6, 40.1, 47.5, 47.7, 50.1, 51.0, 65.9, 69.4, 70.2, 72.6, 76.0, 78.4, 78.8, 82.4, 84.6,
103.7, 153.8, 168.0, 168.2, 169.3, 203.7

I-8

MS(FAB):826+(M+H+).HRMS(FAB): calcd for C42H66F2N3O11 826.4665 found 826.4671
IR(KBr):3437, 3062, 2974, 2938, 2878, 2786, 1752, 1717, 1674, 1534, 1497, 1455, 1380,
1362, 1325, 1305, 1255, 1221, 1166, 1141, 1108, 1079, 1050, 991, 951, 898, 834, 747,
700, 627, 554, 512, 430, 407(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.4, 14.3, 15.6, 16.4, 19.1, 19.9, 21.1, 22.1, 26.4, 28.2,
31.0, 33.2, 33.7, 38.1, 38.8, 40.2, 47.6, 49.8, 51.2, 65.8, 69.5, 70.3, 72.9, 76.3, 76.4, 78.3,
78.7, 85.4, 85.5, 87.0, 103.7, 125.7, 126.3, 128.2, 128.3, 129.5, 132.7, 141.5, 168.1, 169.2,
170.5, 204.2

I-9

MS(FAB):776+(M+H+).HRMS(FAB): calcd for C40H62N3O12 776.4333 found 776.4338
IR(KBr):3435, 2974, 2938, 2879, 1810, 1751, 1715, 1675, 1530, 1455, 1379, 1323, 1283,
1258, 1231, 1166, 1110, 1078, 1048, 994, 954, 932, 891, 775, 752, 700, 582, 530,
456(cm-1)
13C-NMR(CDCl3):δ(ppm)10.4, 13.0, 14.2, 15.3, 15.5, 18.7, 19.8, 21.1, 22.4, 26.3, 28.2,
33.1, 38.0, 40.1, 43.2, 47.5, 49.6, 51.0, 65.8, 69.4, 70.2, 72.9, 76.3, 78.2, 78.5, 82.4, 84.4,
103.6, 127.4, 128.1, 128.6, 137.9, 153.8, 167.7, 168.9, 170.1, 204.0

I-10

MS(SI):847+(M+H+).HRMS(SI):calcd for C44H71N4O12 847.4986 found 846.4993
IR(KBr):3451, 2974, 2938, 2880, 2786, 1810, 1751, 1689, 1632, 1591, 1457, 1380, 1324,
1284, 1257, 1231, 1166, 1110, 1078, 1048, 994, 954, 933, 889, 834, 776, 695, 618, 531,
457(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.2, 15.3, 15.5, 18.7, 19.7, 21.0, 22.2, 26.2, 28.1,
29.5, 31.0, 31.9, 33.1, 37.9, 38.7, 40.0, 40.8, 47.5, 49.6, 50.9, 65.7, 69.3, 70.1, 72.9, 76.0,
78.3, 78.6, 82.2, 84.4, 103.6, 113.0, 128.8, 129.6, 148.9, 153.7, 167.3, 169.0, 170.0, 203.8

I-11

MS(FAB):854+(M+H+).HRMS(FAB): calcd for C46H68N3O12 854.4803 found 854.4799
IR(KBr):3435, 2972, 2937, 2877, 1811, 1751, 1716, 1675, 1532, 1456, 1380, 1362, 1323,
1304, 1283, 1258, 1233, 1219, 1167, 1142, 1109, 1078, 1048, 1004, 993, 953, 931, 893,
799, 779, 555, 532(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 14.3, 15.4, 15.6, 18.9, 19.9, 21.1, 22.3, 26.4, 28.2,
30.2, 33.2, 38.0, 39.1, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 73.0, 76.1, 78.4, 78.7, 82.3,
84.6, 103.7, 123.7, 125.4, 125.5, 125.8, 125.9, 126.6, 128.7, 131.8, 133.8, 137.5, 153.8,
167.5, 169.2, 170.3, 203.9

I-12

MS(FAB):880+(M+H+).HRMS(FAB): calcd for C48H70N3O12 880.4960 found 880.4963
IR(KBr):3433, 3025, 2973, 2936, 2878, 1811, 1751, 1716, 1675, 1531, 1494, 1455, 1378,
1323, 1304, 1282, 1258, 1232, 1166, 1109, 1078, 1048, 994, 953, 891, 774, 752, 701,
535(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.3, 26.3, 28.2,
33.1, 34.8, 38.0, 38.2, 40.2, 47.6, 49.1, 49.8, 51.0, 65.8, 69.5, 70.3, 73.0, 76.0, 78.4, 78.6,
82.4, 84.5, 103.7, 126.1, 127.7, 127.8, 128.4, 144.4, 153.7, 167.4, 169.1, 170.2, 203.9

I-13

MS(FAB):778+(M+H+). HRMS(FAB): calcd for C41H68N3O11 778.4854 found 778.4852
IR(KBr):3435, 3085, 3061, 3025, 2974, 2938, 2876, 2785, 1744, 1714, 1683, 1604, 1531,
1497, 1455, 1403, 1377, 1337, 1302, 1280, 1258, 1172, 1109, 1076, 1051, 1034, 986, 958,
938, 915, 892, 835, 748, 721, 701, 617, 578, 531, 491(cm-1)
13C-NMR(CDCl3):δ(ppm)10.6, 13.8, 14.5, 15.0, 16.2, 18.6, 19.7, 21.2, 21.4, 26.7, 28.3,
31.1, 33.1, 33.3, 37.8, 38.5, 40.2, 46.1, 49.8, 50.8, 65.8, 69.4, 70.1, 70.3, 72.7, 73.8, 78.0,
78.1, 103.3, 125.9, 128.2, 128.3, 141.2, 169.5, 172.7, 205.5

I-14

MS(FAB):794+(M+H+).HRMS(FAB): calcd for C39H64N5O12 794.4551 found 794.4552
IR(KBr):3430, 3112, 2971, 2933, 2879, 2786, 1806, 1751, 1714, 1673, 1536, 1455, 1378,
1321, 1284, 1257, 1232, 1166, 1110, 1078, 1049, 995, 954, 933, 892, 833, 775, 752, 692,
665, 624, 561, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.3,
29.6, 30.9, 33.1, 36.3, 37.9, 40.2, 44.7, 47.6, 49.7, 51.0, 65.8, 69.5, 70.2, 72.8, 75.9, 78.5,
82.3, 84.7, 103.7, 119.2, 129.3, 153.8, 167.7, 169.4, 170.8, 203.8

I-15

MS(FAB):832+(M+H+).HRMS(FAB): calcd for C44H70N3O12 832.4959 found 832.4968
IR(KBr):3435, 2972, 2936, 2877, 2857, 2785, 1811, 1751, 1717, 1671, 1534, 1496, 1455,
1380, 1362, 1323, 1304, 1283, 1258, 1234, 1219, 1167, 1142, 1109, 1078, 1048, 1004,
992, 953, 932, 893, 835, 773, 749, 700, 627, 569, 531, 513, 455, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.6, 18.9, 19.9, 21.1, 22.3, 26.3, 26.6,
28.1, 29.3, 31.1, 33.1, 35.7, 38.0, 39.1, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 73.0, 76.1,
78.4, 78.7, 82.3, 84.5, 103.8, 125.5, 128.1, 128.4, 142.6, 153.8, 167.4, 169.2, 170.2, 203.9

I-16

MS(FAB):805+(M+H+).HRMS(FAB): calcd for C41H65N4O12 805.4599 found 805.4604
IR(KBr):3432, 2971, 2934, 2877, 2784, 1809, 1751, 1716, 1674, 1603, 1534, 1456, 1416,
1378, 1322, 1305, 1284, 1259, 1222, 1166, 1110, 1078, 1048, 994, 954, 933, 891, 800,
776, 629, 578, 512(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.3,
29.6, 32.4, 33.1, 37.9, 38.7, 40.1, 47.6, 49.8, 51.0, 65.8, 69.4, 70.2, 72.9, 75.9, 78.4, 78.6,
82.3, 84.6, 103.7, 123.9, 149.5, 153.8, 167.6, 169.3, 170.5, 203.8

I-17

MS(SI):805+(M+H+).HRMS(SI):calcd for C41H65N4O12 805.4595 found 805.4606
IR(KBr):3433, 2972, 2937, 2878, 2784, 1810, 1751, 1716, 1673, 1575, 1534, 1456, 1423,
1380, 1363, 1322, 1305, 1284, 1258, 1234, 1220, 1167, 1142, 1109, 1079, 1048, 1005,
993, 953, 931, 893, 774, 714, 629, 558, 532(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.3,
30.2, 30.6, 33.1, 37.9, 38.6, 40.1, 47.6, 49.8, 51.0, 65.8, 69.4, 70.2, 72.9, 75.9, 78.4, 78.6,
82.3, 84.6, 103.7, 123.3, 135.9, 136.9, 147.2, 149.7, 153.8, 167.6, 169.3, 170.4, 203.8

I-18

MS(FAB):802+(M+H+). HRMS(FAB): calcd for C42H64N3O12 802.4490 found 802.4489
IR(KBr):3436, 2974, 2938, 2879, 2785, 1811, 1752, 1717, 1677, 1525, 1495, 1455, 1380,
1362, 1324, 1304, 1283, 1257, 1233, 1167, 1141, 1109, 1078, 1047, 1004, 992, 931, 892,
859, 835, 801, 773, 748, 694, 630, 556, 512, 456, 432(cm-1)
13C-NMR(CDCl3):δ(ppm)10.0, 12.9, 14.3, 15.3, 15.5, 18.8, 19.9, 21.1, 22.1, 26.3, 28.2,
33.2, 38.0, 40.2, 41.4, 47.5, 49.8, 51.0, 65.9, 69.5, 70.2, 73.0, 75.9, 78.4, 78.5, 82.4, 84.5,
103.7, 125.0, 126.5, 127.4, 128.4, 132.6, 136.6, 153.7, 167.6, 169.0, 170.2, 204.0

I-19

MS(FAB):806+(M+H+).HRMS(FAB): calcd for C41H64N3O13 806.4439 found 806.4441
IR(KBr):3438, 2973, 2937, 2878, 2785, 1811, 1751, 1717, 1679, 1637, 1599, 1588, 1528,
1497, 1457, 1380, 1363, 1324, 1303, 1285, 1244, 1169, 1141, 1109, 1078, 1048, 1004,
993, 953, 931, 891, 773, 755, 693, 555, 512(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.2, 15.2, 15.5, 18.8, 19.8, 21.1, 22.2, 26.4, 28.1,
33.2, 38.0, 38.4, 40.1, 47.5, 49.6, 51.0, 65.7, 66.3, 69.4, 70.1, 72.7, 76.0, 78.2, 78.5, 82.1,
84.4, 103.4, 114.2, 120.6, 129.2, 153.6, 158.2, 167.3, 168.8, 170.1, 203.6

I-20

MS(FAB):800+(M+H+). HRMS(FAB): calcd for C42H62N3O12 800.4334 found 800.4336
IR(KBr):3442, 2974, 2938, 2879, 2839, 2785, 1811, 1752, 1716, 1683, 1599, 1522, 1490,
1456, 1381, 1361, 1324, 1304, 1282, 1257, 1233, 1167, 1141, 1109, 1078, 1047, 1004,
993, 953, 931, 915, 892, 859, 835, 801, 758, 693, 669, 628, 556, 527, 456(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 12.9, 14.3, 15.3, 15.4, 18.8, 19.8, 21.1, 22.2, 26.4, 28.2,
29.5, 33.3, 38.0, 40.2, 47.5, 49.8, 51.0, 65.8, 69.4, 70.2, 72.8, 76.0, 78.3, 78.5, 82.3, 83.0,
84.5, 103.7, 122.7, 128.1, 128.2, 131.8, 153.8, 167.8, 169.0, 170.0, 204.0

I-21

MS(FAB):802+(M+H+). HRMS(FAB): calcd for C42H64N3O12 802.4490 found 802.4493
IR(KBr): 3436, 3055, 2973, 2938, 2879, 2785, 1811, 1751, 1717, 1676, 1527, 1494, 1456,
1381, 1363, 1325, 1304, 1283, 1257, 1233, 1166, 1141, 1109, 1078, 1047, 1004, 993, 953,
932, 891, 860, 835, 803, 773, 701, 628, 531, 456, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.0, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.3, 26.3, 28.2,
33.2, 37.4, 38.0, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.2, 72.9, 76.1, 78.3, 78.6, 82.3, 84.5,
103.7, 127.0, 127.8, 128.2, 128.7, 131.5, 136.3, 153.7, 167.5, 169.0, 170.1, 204.0

I-22

MS(SI):855+(M+H+).HRMS(SI):calcd for C45H67N4O12 855.4751 found 855.4749
IR(KBr):3434, 2971, 2935, 2877, 2854, 2784, 1811, 1751, 1717, 1673, 1591, 1533, 1509,
1456, 1380, 1362, 1322, 1305, 1284, 1257, 1234, 1219, 1167, 1141, 1109, 1078, 1048,
1004, 992, 953, 931, 892, 835, 771, 628, 557, 532, 455(cm-1)
1H-NMR(CDCl3) δ(ppm) : 0.87(3H, t, J = 7.2 Hz), 1.00(3H, d, J = 6.9 Hz), 1.23(3H, d, J =
6.0 Hz), 1.24(3H, d, J = 7.5 Hz), 1.28(3H, d, J = 7.2 Hz), 1.37(3H, d, J = 7.2 Hz), 1.39(3H,
s), 1.56(3H, s), 1.54-2.12(8H, m), 2.27(6H, s), 2.46(1H, m), 2.56(1H, q, J = 7.2 Hz),
2.69(3H, s), 3.01(1H, quintet, J = 7.5 Hz), 3.13(2H, dd, J = 4.2 and 8.4 Hz), 3.18(1H, dd,
J = 7.5 and 9.9 Hz), 3.33(1H, m), 3.54(3H, m), 3.68(1H, m), 3.83(1H, q, J = 6.9 Hz),
4.22(1H, d, J = 8.1 Hz), 4.29(1H, d, J = 7.5 Hz), 4.44 and 4.49(2H, Abq, J = 14.1 Hz),
4.85(1H, s), 4.99(1H, dd, J = 2.7 and 10.5 Hz), 7.23(1H, brt, J = 6.3 Hz), 7.31(1H, d, J =
4.5 Hz), 7.57(1H, m), 7.69(1H, m), 8.05(1H, dd, J = 0.9 and 8.4 Hz), 8.09(1H, d, J = 8.1
Hz), 8.81(1H, d, J = 4.5 Hz)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.2,
29.3, 29.7, 33.1, 38.0, 39.0, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 73.0, 75.9, 78.4, 78.6,
82.3, 84.6, 103.7, 120.6, 123.5, 126.3, 127.5, 128.9, 130.0, 147.5, 148.2, 150.2, 153.8,
167.6, 169.3, 170.5, 203.8

I-23

MS(SI):873+(M+H+).HRMS(SI):calcd for C46H73N4O12 873.5221 found 873.5225
IR(KBr):3435, 2971, 2936, 2876, 2789, 1811, 1751, 1717, 1673, 1602, 1570, 1533, 1505,
1455, 1380, 1362, 1323, 1305, 1284, 1258, 1233, 1216, 1167, 1141, 1109, 1078, 1047,
1004, 992, 953, 931, 893, 835, 773, 749, 695, 627, 553, 531, 456, 407(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 14.3, 15.3, 15.6, 18.9, 19.9, 21.2, 22.3, 26.0, 26.1,
26.3, 27.1, 28.2, 29.7, 33.1, 33.6, 33.7, 35.9, 38.0, 38.8, 39.3, 40.2, 47.4, 47.6, 49.8, 49.9,
51.1, 65.9, 69.5, 70.3, 73.0, 76.1, 78.4, 78.7, 82.3, 84.5, 103.7, 110.7, 115.8, 126.6, 127.0,
128.5, 128.6, 145.8, 153.8, 167.4, 169.2, 170.2, 203.9

I-24

MS(FAB):818+(M+H+). HRMS(FAB): calcd for C43H68N3O12 818.4803 found 818.4803
IR(CHCl3):3426, 3350, 2970, 2934, 2870, 2830, 2780, 1805, 1751, 1715, 1663, 1536,
1490, 1455, 1381, 1361, 1345, 1322, 1305, 1282, 1256, 1230, 1220, 1165, 1139, 1107,
1074, 1046, 1004, 990, 950, 931, 907, 831, 666, 627, 560, 543, 536, 529, 524, 518, 514,
512(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.2, 15.3, 15.6, 18.8, 19.2, 19.9, 21.1, 22.2, 26.3,
28.1, 29.7, 30.4, 33.1, 38.0, 39.0, 40.2, 47.6, 49.7, 51.0, 65.8, 69.5, 70.2, 73.0, 76.0, 78.3,
78.6, 82.3, 84.5, 103.7, 125.8, 128.6, 130.0, 135.8, 139.6, 153.8, 167.4, 169.1, 170.2,
203.9

I-25

MS(FAB):818+(M+H+). HRMS(FAB): calcd for C43H68N3O12 818.4803 found 818.4802
IR(CHCl3):3426, 3350, 2998, 2970, 2934, 2870, 2782, 1805, 1751, 1715, 1663, 1607,
1536, 1454, 1381, 1361, 1345, 1322, 1305, 1282, 1255, 1229, 1219, 1165, 1139, 1107,
1075, 1046, 1004, 990, 950, 930, 907, 832, 723, 697, 667, 628, 550, 529, 525, 518, 514,
508(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.2, 15.3, 15.6, 18.8, 19.9, 21.1, 21.3, 22.3, 26.3,
28.1, 30.9, 33.1, 33.2, 38.0, 38.8, 40.2, 47.6, 49.7, 51.0, 65.8, 69.5, 70.2, 73.0, 76.0, 78.4,
78.7, 82.3, 84.5, 103.7, 125.3, 126.5, 128.1, 129.1, 137.7, 141.4, 153.8, 167.4, 169.1,
170.2, 203.9

I-26

MS(FAB):818+(M+H+). HRMS(FAB): calcd for C43H68N3O12 818.4803 found 818.4799
IR(CHCl3):3426, 3354, 2970, 2934, 2870, 2780, 1805, 1751, 1715, 1663, 1537, 1515,
1454, 1380, 1361, 1345, 1323, 1305, 1282, 1256, 1230, 1220, 1165, 1139, 1107, 1075,
1046, 1004, 990, 950, 930, 907, 832, 665, 626, 553, 540, 537, 532, 523, 517, 513,
508(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.2, 15.3, 15.6, 18.8, 19.9, 20.9, 21.1, 22.2, 26.3,
28.1, 30.9, 32.7, 33.1, 38.0, 38.7, 40.2, 47.6, 49.7, 51.0, 65.8, 69.5, 70.2, 72.9, 76.0, 78.4,
78.7, 82.3, 84.5, 103.7, 128.2, 128.9, 135.0, 138.4, 153.8, 167.5, 169.1, 170.2, 203.9

I-27

MS(FAB):810+(M+H+). HRMS(FAB): calcd for C42H72N3O12 810.5116 found 810.5117
IR(KBr): 3439, 2973, 2929, 2851, 2786, 1814, 1752, 1717, 1674, 1533, 1455, 1380, 1362,
1323, 1304, 1284, 1258, 1233, 1219, 1167, 1142, 1109, 1078, 1048, 1004, 992, 953, 931,
891, 860, 835, 801, 773, 755, 694, 629, 555, 532, 457, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.3, 26.3, 26.6,
26.8, 28.2, 33.1, 33.2, 34.6, 37.3, 38.0, 39.5, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 73.0,
76.1, 78.4, 78.7, 82.3, 84.5, 103.7, 153.8, 167.4, 169.1, 170.1, 203.9

I-28

MS(FAB):821+(M+H+). HRMS(FAB): calcd for C41H65N4O13 821.4548 found 821.4550
IR(CHCl3):3422, 3348, 2970, 2934, 2870, 2832, 1802, 1751, 1715, 1657, 1584, 1538,
1455, 1381, 1360, 1344, 1323, 1304, 1282, 1232, 1219, 1165, 1107, 1078, 1047, 1005,
990, 950, 930, 907, 725, 666, 525, 521(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.2, 15.3, 15.6, 18.7, 19.8, 21.1, 22.2, 26.4, 28.1,
29.5, 33.1, 35.3, 38.1, 40.2, 46.6, 47.6, 49.6, 51.0, 65.7, 69.4, 70.2, 72.7, 76.1, 78.4, 78.8,
82.5, 84.6, 103.7, 106.1, 120.6, 137.9, 139.4, 154.0, 162.8, 167.2, 169.2, 170.4, 203.9

I-29

MS(FAB):821+(M+H+). HRMS(FAB): calcd for C41H65N4O13 821.4548 found 821.4545
IR(CHCl3):3332, 2970, 2936, 2870, 1804, 1750, 1663, 1639, 1564, 1455, 1381, 1363,
1347, 1323, 1305, 1282, 1256, 1233, 1219, 1186, 1167, 1139, 1107, 1073, 1048, 1005,
990, 951, 907, 848, 723, 665(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.7, 14.3, 15.2, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.3,
30.7, 33.1, 35.9, 37.8, 40.2, 47.6, 49.7, 51.0, 54.6, 65.8, 69.5, 70.2, 72.7, 75.8, 78.5, 78.6,
82.3, 84.9, 103.7, 118.6, 140.1, 153.9, 167.9, 169.6, 171.1, 178.9, 203.7

I-30

MS(FAB):854+(M+H+). HRMS(FAB): calcd for C46H68N3O12 854.4803 found 854.4810
IR(CHCl3):3428, 3350, 2970, 2934, 2870, 2780, 1805, 1751, 1714, 1661, 1537, 1507,
1454, 1381, 1361, 1345, 1322, 1304, 1282, 1256, 1232, 1222, 1165, 1138, 1107, 1078,
1047, 1004, 990, 950, 930, 907, 855, 817, 666, 625, 559, 544, 532, 520, 516, 510(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 12.9, 14.2, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.1,
30.7, 33.1, 33.3, 38.0, 38.9, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.2, 73.0, 76.0, 78.4, 78.7,
82.3, 84.5, 103.7, 124.9, 125.7, 126.3, 127.2, 127.4, 127.8, 131.9, 133.6, 139.0, 153.8,
162.8, 167.5, 169.2, 170.2, 203.8

I-31

MS(FAB):808+(M+H+). HRMS(FAB): calcd for C42H70N3O12 808.4959 found 808.4959
IR(KBr): 3437, 2972, 2936, 2879, 2836, 2785, 1812, 1752, 1717, 1673, 1533, 1456, 1380,
1362, 1323, 1304, 1283, 1257, 1233, 1219, 1166, 1141, 1109, 1078, 1048, 1004, 993, 953,
931, 892, 860, 834, 802, 773, 755, 694, 628, 531, 456, 431, 419(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.0, 14.3, 15.3, 15.6, 18.9, 19.9, 21.1, 22.3, 22.5, 22.9,
25.2, 26.3, 27.3, 28.1, 28.2, 33.1, 35.2, 38.0, 38.9, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.2,
73.0, 76.1, 78.4, 78.7, 82.3, 84.5, 103.7, 121.2, 136.7, 153.8, 167.4, 169.1, 170.1, 203.9

I-32

MS(FAB):806+(M+H+).HRMS(FAB): calcd for C41H64N3O13 806.4439 found 806.4438
IR(KBr):3431, 2973, 2938, 2879, 2785, 1811, 1752, 1700, 1654, 1637, 1497, 1455, 1380,
1323, 1305, 1283, 1257, 1233, 1167, 1142, 1109, 1080, 1048, 1004, 992, 953, 932, 892,
834, 773, 751, 700, 631, 558, 529, 458(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.4, 15.5, 18.7, 19.9, 21.1, 22.2, 26.3, 28.2,
33.1, 34.4, 38.0, 40.2, 47.5, 49.8, 51.0, 65.8, 69.5, 70.2, 72.3, 76.0, 78.3, 78.4, 82.3, 84.6,
103.6, 126.1, 128.3, 128.9, 137.9, 153.6, 167.5, 167.9, 169.1, 204.0

I-33

MS(FAB):805+(M+H+).HRMS(FAB): calcd for C41H65N4O12 805.4599 found 805.4594
IR(KBr):3434, 2972, 2937, 2878, 2784, 1810, 1751, 1716, 1674, 1591, 1568, 1533, 1456,
1380, 1363, 1322, 1305, 1284, 1257, 1233, 1219, 1167, 1109, 1078, 1048, 1004, 993, 953,
932, 892, 835, 772, 755, 694, 628, 557, 531, 457, 403(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.0, 14.3, 15.3, 15.6, 18.9, 19.9, 21.1, 22.3, 26.4, 28.3,
29.2, 33.2, 35.3, 38.1, 38.5, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 73.0, 76.1, 78.4, 78.7,
82.4, 84.6, 103.7, 121.0, 122.8, 136.3, 149.1, 153.8, 161.2, 167.4, 169.2, 170.2, 203.9

I-34

MS(FAB):880+(M+H+). HRMS(FAB): calcd for C48H70N3O12 880.4960 found 880.4963
IR(CHCl3):3436, 3354, 3024, 3006, 2976, 2936, 2874, 1805, 1751, 1715, 1665, 1536,
1485, 1454, 1410, 1381, 1362, 1346, 1319, 1305, 1282, 1256, 1229, 1220, 1166, 1139,
1107, 1078, 1045, 1004, 989, 949, 906, 833, 685, 655, 521, 512(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.2, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.1,
30.8, 32.7, 33.1, 38.0, 38.8, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.2, 73.0, 76.0, 78.4, 78.6,
82.3, 84.5, 103.7, 126.8, 126.9, 127.0, 128.6, 128.7, 138.6, 140.7, 141.1, 153.8, 167.5,
169.2, 170.3, 203.8

I-35

MS(FAB):855+(M+H+).HRMS(FAB): calcd for C45H67N4O12 855.4755 found 855.4747
IR(KBr):3433, 2972, 2937, 2878, 2784, 1810, 1751, 1717, 1673, 1637, 1569, 1534, 1496,
1456, 1380, 1363, 1323, 1305, 1283, 1258, 1234, 1219, 1167, 1141, 1109, 1079, 1048,
1004, 992, 953, 931, 893, 861, 835, 787, 773, 754, 682, 614, 556, 530, 480, 456(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.2,
30.4, 30.5, 33.1, 38.0, 38.8, 40.2, 47.6, 49.8, 51.0, 65.9, 69.5, 70.2, 73.0, 75.9, 78.4, 78.6,
82.3, 84.6, 103.7, 125.2, 126.4, 127.5, 128.2, 128.4, 129.0, 134.2, 146.8, 152.0, 153.8,
167.6, 169.3, 170.5, 203.8

I- 36

MS(FAB):818+(M+H+). HRMS(FAB): calcd for C43H68N3O12 818.4803 found 818.4809
IR(KBr): 3438, 3061, 2974, 2938, 2878, 2785, 1812, 1752, 1717, 1673, 1529, 1497, 1455,
1379, 1322, 1283, 1257, 1233, 1167, 1142, 1109, 1082, 1047, 1005, 992, 952, 932, 899,
835, 801, 773, 750, 700, 630, 573, 555, 533, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.7, 15.9, 18.9, 19.9, 21.2, 22.2, 26.2,
28.2, 30.8, 33.0, 33.2, 37.9, 39.0, 40.2, 47.7, 49.7, 51.1, 65.8, 69.5, 70.3, 76.0, 78.4, 78.5,
78.6, 82.4, 84.5, 103.7, 125.6, 128.2, 128.3, 141.7, 153.8, 166.1, 169.1, 172.0, 203.9

I-37

MS(FAB):818+(M+H+). HRMS(FAB): calcd for C43H68N3O12 818.4803 found 818.4803
IR(KBr): 3438, 3061, 2974, 2937, 2878, 2785, 1811, 1751, 1717, 1671, 1525, 1497, 1455,
1379, 1321, 1283, 1257, 1233, 1167, 1142, 1109, 1082, 1048, 1005, 992, 953, 932, 899,
835, 802, 773, 749, 700, 621, 573, 510, 420(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.0, 14.2, 15.5, 15.7, 17.5, 18.8, 19.7, 21.2, 22.3, 26.3,
28.2, 31.1, 33.1, 38.1, 38.7, 40.2, 47.7, 49.7, 51.0, 65.8, 69.5, 70.3, 76.2, 78.3, 78.8, 79.2,
82.5, 84.5, 103.7, 125.8, 128.2, 128.3, 128.4, 141.5, 153.9, 166.5, 169.1, 172.8, 203.9

I-38

MS(FAB):819+(M+H+).HRMS(FAB): calcd for C42H67N4O12 819.4755 found 819.4755
IR(KBr):3429, 2974, 2938, 2880, 2786, 1808, 1752, 1716, 1674, 1600, 1570, 1528, 1508,
1456, 1376, 1361, 1323, 1304, 1283, 1257, 1235, 1212, 1166, 1142, 1108, 1079, 1049,
1004, 992, 953, 932, 893, 860, 835, 801, 773, 749, 693, 634, 581, 551, 517, 456(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 14.3, 15.3, 15.5 ,18.8, 19.9, 21.2, 22.3, 26.3, 28.3,
33.2, 36.2, 38.0, 38.1, 40.2, 47.6, 49.7, 51.0, 51.6, 65.9, 69.5, 70.3, 72.9, 76.1, 78.4, 78.6,
82.4, 84.7, 103.7, 112.4, 116.4, 129.1, 149.3, 153.8, 167.4, 169.2, 170.6, 203.9

I-39

MS(FAB):822+(M+H+).HRMS(FAB): calcd for C42H65F1N3O12 822.4552 found 822.4551
IR(KBr):3435, 2973, 2938, 2878, 2785, 1811, 1751, 1717, 1673, 1601, 1533, 1509, 1456,
1380, 1362, 1323, 1304, 1283, 1257, 1220, 1166, 1142, 1109, 1078, 1048, 1004, 992, 953,
931, 892, 834, 774, 755, 696, 628, 545, 505, 456, 420(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.5, 18.9, 19.9, 21.1, 22.3, 26.3, 28.2,
31.0, 32.4, 33.2, 38.0, 38.7, 40.2, 47.6, 49.8, 51.1, 65.9, 69.6, 70.3, 73.0, 76.1, 78.5, 78.6,
82.3, 84.6, 103.8, 114.7, 115.2, 129.6, 129.8, 137.2, 137.3, 153.7, 158.8, 163.6, 167.6,
169.2, 170.3, 203.8

I-40

MS(FAB):810+(M+H+). HRMS(FAB): calcd for C40H64N3O12S1 810.4211 found 810.4219
IR(CHCl3):3424, 3350, 3016, 2970, 2934, 2870, 1805, 1751, 1714, 1663, 1537, 1454,
1381, 1361, 1345, 1321, 1305, 1282, 1255, 1232, 1220, 1165, 1139, 1107, 1075, 1046,
1004, 990, 950, 696, 666, 533, 523(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 14.3, 15.3, 15.5, 18.8, 19.9, 21.1, 22.3, 26.3, 27.2,
28.6, 31.2, 33.2, 38.0, 38.5, 40.2, 47.5, 49.7, 51.0, 65.8, 69.3, 70.2, 72.9, 76.1, 78.4, 78.5,
82.3, 84.6, 103.5, 122.9, 124.3, 126.7, 144.2, 153.8, 167.6, 169.2, 170.4, 203.9

I-41

MS(FAB):810+(M+H+). HRMS(FAB): calcd for C40H64N3O12S1 810.4211 found 810.4219
IR(CHCl3):3426, 3348, 2970, 2932, 2860, 2780, 1805, 1751, 1714, 1661, 1537, 1454,
1381, 1361, 1345, 1321, 1305, 1283, 1254, 1232, 1219, 1166, 1139, 1107, 1078, 1046,
1004, 990, 950, 930, 907, 859, 833, 666, 630, 560, 533, 524, 519, 511(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.6, 18.9, 19.9, 21.2, 22.3, 26.3, 27.6,
28.2, 30.0, 33.2, 38.0, 38.8, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 73.0, 76.1, 78.4, 78.6,
82.4, 84.5, 103.8, 120.2, 125.1, 128.2, 141.8, 153.8, 167.5, 169.2, 170.3, 203.9

I-42

MS(FAB):855+(M+H+). HRMS(FAB): calcd for C45H67N4O12 855.4755 found 855.4762
IR(CHCl3):3426, 3350, 2970, 2934, 2870, 1805, 1751, 1714, 1663, 1600, 1535, 1503,
1455, 1425, 1381, 1361, 1345, 1322, 1305, 1282, 1256, 1231, 1165, 1139, 1107, 1078,
1046, 1004, 990, 950, 891, 828, 665, 512(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.3, 15.4, 15.5, 18.9, 19.9, 21.1, 22.3, 26.4, 28.2,
29.3, 33.2, 36.3, 38.1, 38.8, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 73.0, 76.2, 78.4, 78.7,
82.4, 84.6, 103.7, 121.4, 125.6, 126.8, 127.4, 128.9, 129.2, 136.3, 147.9, 153.9, 161.8,
167.4, 169.1, 170.2, 203.9

I-43

MS(FAB):855+(M+H+). HRMS(FAB): calcd for C45H67N4O12 855.4755 found 855.4751
IR(CHCl3):3424, 3348, 2970, 2934, 2870, 1805, 1751, 1714, 1665, 1623, 1558, 1535,
1502, 1454, 1381, 1360, 1344, 1321, 1304, 1282, 1253, 1232, 1220, 1165, 1139, 1107,
1076, 1046, 1004, 990, 950, 931, 887, 823, 666, 532, 518, 513, 509(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.3, 15.4, 15.6, 18.9, 19.9, 21.1, 22.3, 26.4, 28.2,
28.7, 32.2, 33.3, 38.2, 38.7, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 73.1, 76.2, 78.4, 78.8,
82.4, 84.6, 103.7, 119.2, 125.2, 126.9, 127.1, 127.3, 129.8, 136.2, 141.7, 153.9, 161.0,
167.3, 169.1, 170.1, 203.9

I-44

MS(FAB):855+(M+H+). HRMS(FAB): calcd for C45H67N4O12 855.4755 found 855.4757
IR(CHCl3):3436, 3357, 3022, 2976, 2940, 2879, 2838, 2788, 1807, 1752, 1716, 1665,
1624, 1602, 1586, 1536 ,1504, 1455, 1382, 1362, 1347, 1323, 1306, 1284, 1256, 1232,
1218, 1211, 1167, 1141, 1108, 1074, 1048, 1005, 991, 952, 931, 895, 860, 834(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.3, 26.3, 27.5,
28.2, 30.2, 33.2, 38.0, 39.1, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 73.0, 76.0, 78.4, 78.6,
82.3, 84.6, 103.8, 122.9, 126.7, 128.2, 128.4, 130.2, 130.7, 134.6, 142.4, 151.3, 153.7,
167.5, 169.2, 170.4, 203.8

I-45

MS(FAB):855+(M+H+). HRMS(FAB): calcd for C45H67N4O12 855.4755 found 855.4746
IR(CHCl3):3436, 3356, 3023, 3018, 2976, 2940, 2879, 2838, 2788, 1807, 1752, 1716,
1663, 1614, 1597, 1574, 1537, 1504, 1455, 1382, 1363, 1347, 1323, 1306, 1284, 1256,
1234, 1225, 1221, 1213, 1167, 1141, 1108, 1074, 1048, 1005, 991, 952, 931, 893, 861,
833, 804(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.2, 15.3, 15.5, 18.8, 19.9, 21.1, 22.2, 26.3, 28.2,
29.5, 30.3, 33.1, 38.0, 39.0, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 73.0, 76.0, 78.4, 78.6,
82.3, 84.6, 103.7, 120.7, 126.2, 126.9, 127.9, 129.1, 132.2, 138.1, 148.7, 149.8, 153.7,
167.6, 169.2, 170.4, 203.8

I-46

MS(FAB):832+(M+H+). HRMS(FAB): calcd for C44H70N3O12 832.4960 found 832.4946
IR(KBr): 3443, 3062, 2975, 2938, 2878, 2785, 1812, 1751, 1717, 1669, 1525, 1498, 1455,
1378, 1362, 1323, 1305, 1284, 1258, 1218, 1166, 1109, 1083, 1047, 1005, 992, 954, 930,
835, 801, 771, 750, 699, 580, 558, 457(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 14.3, 15.3, 15.6, 18.8, 19.7, 21.2, 22.3, 24.3, 25.2,
26.2, 28.2, 31.0, 33.2, 37.9, 38.9, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 76.1, 78.4, 78.5,
82.5, 82.7, 84.5, 103.7, 125.6, 128.2, 128.4, 141.8, 153.8, 166.0, 169.2, 174.8, 204.0

I-47

MS(SI):859+(M+H+).HRMS(SI):calcd for C45H71N4O12 859.5065. found 859.5065.
IR(KBr):3433, 2971, 2936, 2877, 2784, 1811, 1751, 1717, 1673, 1637, 1587, 1560, 1540,
1534, 1509, 1498, 1456, 1408, 1380, 1362, 1322, 1304, 1283, 1257, 1233, 1166, 1141,
1109, 1078, 1048, 1004, 993, 953, 931, 891, 859, 835, 802, 774, 754, 694, 669, 626, 532,
458, 425(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.5, 18.8, 19.9, 21.1, 22.2, 22.7, 22.8,
25.2, 26.3, 28.2, 28.6, 29.2, 33.0, 33.1, 38.0, 39.1, 40.2, 47.6, 49.8, 51.0, 65.9, 69.5, 70.3,
73.0, 76.0, 78.4, 78.6, 82.3, 84.6, 103.7, 121.0, 130.6, 146.2, 148.9, 153.7, 156.8, 167.6,
169.3, 170.5, 203.8

I-48

MS(SI):904+(M+H+).HRMS(SI):calcd for C50H70N3O12 904.4956. found904.4957.
IR(KBr):3434, 3078, 2971, 2936, 2877, 2785, 1810, 1751, 1717, 1671, 1654, 1646, 1636,
1628, 1577, 1569, 1559, 1540, 1533, 1508, 1497, 1490, 1456, 1379, 1362, 1321, 1304,
1283, 1256, 1234, 1167, 1109, 1077, 1048, 1004, 993, 953, 931, 891, 834, 770, 749, 727,
669, 616, 558, 457, 433, 414(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.4, 15.5, 18.9, 19.9, 21.1, 22.3, 26.4, 28.2,
29.6, 30.5, 33.2, 38.0, 39.2, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 73.1, 76.1, 78.4, 78.7,
82.3, 84.6, 103.7, 122.3, 123.1, 124.3, 125.8, 126.0, 126.1, 126.4, 126.5, 128.2, 129.6,
130.6, 131.2, 131.9, 135.6, 153.8, 167.4, 169.1, 170.3, 203.9

I-49

MS(FAB):811+(M+H+). HRMS(FAB): calcd for C39H63N4O12S1 811.4163 found 811.4166
IR(KBr):3433, 3080, 2973, 2938, 2878, 2784, 1809, 1751, 1716, 1673, 1533, 1504, 1455,
1380, 1363, 1323, 1305, 1284, 1257, 1233, 1168, 1141, 1109, 1078, 1047, 1004, 992, 953,
931, 892, 860, 835, 800, 772, 754, 695, 666, 628, 559, 531, 456(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.3, 26.4, 28.2,
29.5, 30.4, 33.2, 38.0, 38.2, 40.2, 47.6, 49.7, 51.0, 65.8, 69.5, 70.3, 72.9, 76.1, 78.4, 78.6,
82.4, 84.6, 103.7, 118.1, 142.2, 153.8, 167.6, 169.2, 170.1, 170.4, 203.9

I-50

MS(FAB):861+(M+H+).HRMS(FAB):calcd for C43H65N4O12S 1 861.4320 found 861.4329
IR(CHCl3):3424, 3348, 2970, 2934, 2870, 2830, 1805, 1751, 1714, 1665, 1536, 1454,
1381, 1361, 1345, 1306, 1282, 1232, 1220, 1165, 1139, 1107, 1075, 1046, 1004, 990, 950,
931, 891, 665, 626, 568, 554, 550, 541, 535, 529, 526, 519, 513(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.5, 18.9, 19.9, 21.1, 22.3, 26.4, 28.2,
29.1, 31.5, 33.2, 38.0, 38.3, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 72.9, 76.1, 78.4, 78.6,
82.3, 84.6, 103.7, 121.5, 122.5, 124.5, 125.7, 135.2, 153.2, 153.8, 167.6, 169.2, 170.4,
171.1, 203.9

I-51

MS(FAB):818+(M+H+).HRMS(FAB): calcd for C43H68N3O12 818.4803 found 818.4805
IR(KBr):3427, 3061, 2972, 2938, 2878, 2785, 1812, 1752, 1717, 1671, 1604, 1526, 1496,
1455, 1380, 1362, 1324, 1304, 1283, 1257, 1233, 1219, 1167, 1142, 1109, 1078, 1047,
1005, 992, 953, 932, 892, 859, 835, 801, 773, 750, 700, 628, 556, 515, 457(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.2, 15.4, 15.6, 15.7, 18.9, 19.0, 19.9, 20.7, 20.8,
21.1, 22.3, 26.4, 26.5, 28.2, 32.5, 32.6, 33.2, 38.1, 38.2, 38.3, 38.5, 40.2, 44.8, 47.6, 47.7,
49.9, 50.0, 51.1, 65.9, 69.5, 70.3, 72.9, 73.0, 76.2, 76.3, 78.4, 78.9, 79.0, 82.3, 82.4, 84.5,
103.8, 125.6, 125.7, 128.2, 128.3, 128.4, 141.7, 141.9, 153.8, 153.9, 167.9, 168.0, 169.2,
169.5, 203.8, 203.9

I-52

MS(FAB):820+(M+H+).HRMS(FAB): calcd for C42H66N3O13 820.4596 found 820.4603
IR(KBr):3433, 3086, 3062, 2973, 2937, 2879, 2786, 1810, 1751, 1717, 1670, 1534, 1497,
1455, 1380, 1323, 1305, 1283, 1257, 1234, 1167, 1142, 1109, 1078, 1048, 1004, 993, 953,
932, 891, 859, 835, 774, 748, 701, 630, 556, 455, 404(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.0, 14.3, 14.4, 15.3, 15.7, 18.8, 18.9, 19.8, 21.1, 22.3,
22.4, 26.5, 26.6, 28.2, 33.8, 38.1, 40.2, 41.6, 41.7, 44.6, 44.7, 47.6, 49.7, 49.8, 51.1, 51.2,
65.7, 65.8, 69.5, 70.3, 71.7, 71.8, 72.8, 76.1, 78.5, 78.6, 78.8, 78.9, 82.1, 82.3, 84.9, 85.0,
103.7, 103.8, 126.3, 128.4, 129.3, 129.4, 137.9, 154.0, 154.1, 167.5, 167.7, 169.2, 170.9,
203.8, 203.9

I-53

MS(FAB):832+(M+H+).HRMS(FAB): calcd for C44H70N3O12 832.4959 found 832.4952
IR(KBr):3442, 3060, 3025, 2971, 2937, 2877, 2785, 1812, 1752, 1717, 1683, 1636, 1533,
1495, 1455, 1381, 1363, 1324, 1304, 1283, 1257, 1233, 1218, 1167, 1141, 1109, 1078,
1048, 1004, 992, 953, 932, 892, 859, 835, 800, 774, 754, 728, 703, 669, 631, 555, 529,
456, 433(cm-1)
13C-NMR(CDCl3):δ(ppm)10.6, 13.4, 14.6, 15.9, 16.0, 19.3, 20.3, 21.5, 22.7, 24.9, 26.9,
28.5, 33.6, 36.0, 38.5, 40.5, 46.5, 48.0, 49.3, 50.1, 51.4, 66.2, 69.8, 70.6, 73.3, 76.6, 78.7,
79.3, 82.7, 84.8, 104.2, 126.3, 128.1, 130.8, 138.4, 154.2, 168.4, 169.4, 170.5, 204.2

I-54

MS(FAB):862+(M+H+).HRMS(FAB): calcd for C44H68N3O14 862.4701 found 862.4709
IR(KBr):3437, 3061, 2973, 2937, 2881, 2785, 1811, 1751, 1716, 1684, 1637, 1529, 1496,
1455, 1380, 1361, 1323, 1304, 1283, 1257, 1232, 1219, 1168, 1142, 1109, 1078, 1047,
1004, 993, 952, 933, 892, 858, 835, 800, 773, 753, 701, 669, 634, 554, 440, 411, 403(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.3, 15.4, 15.5, 18.9, 19.9, 21.2, 22.4, 26.5, 28.2,
33.3, 38.2, 40.2, 42.0, 44.2, 47.6, 49.8, 51.1, 65.5, 65.6, 65.9, 69.5, 70.3, 72.9, 76.3, 78.3,
78.9, 82.4, 84.5, 103.8, 109.3, 126.4, 127.9, 130.7, 135.7, 154.0, 168.0, 169.1, 170.1,
203.9

I-55

MS(SI):818+(M+H+).HRMS(SI):calcd for C42H64N3O13 818.4436 found 818.4442
IR(KBr):3429, 2972, 2935, 2879, 2853, 2785, 1869, 1809, 1751, 1719, 1676, 1654, 1646,
1637, 1629, 1577, 1569, 1560, 1541, 1523, 1509, 1498, 1456, 1379, 1362, 1323, 1283,
1257, 1233, 1167, 1109, 1078, 1048, 1004, 993, 953, 932, 892, 859, 834, 799, 774, 754,
701, 669, 555, 477, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.3, 15.3, 15.7, 18.8, 19.8, 21.1, 22.4, 26.6, 28.3,
29.7, 38.3, 40.2, 47.6, 47.7, 48.2, 49.8, 51.1, 65.9, 69.5, 70.3, 72.6, 76.3, 78.4, 79.0, 82.4,
84.7, 103.8, 127.4, 128.9, 129.4, 133.0, 154.1, 167.7, 169.1, 170.4, 202.4, 204.0

I-56

MS(FAB):782+(M+H+).HRMS(FAB): calcd for C40H68N3O12 782.4803 found 782.4793
IR(KBr):3441, 2972, 2930, 2852, 2785, 1813, 1752, 1717, 1676, 1534, 1455, 1380, 1362,
1323, 1304, 1283, 1258, 1233, 1219, 1167, 1109, 1078, 1048, 1004, 992, 953, 932, 892,
860, 835, 801, 773, 755, 694, 631, 568, 530, 457(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.0, 14.3, 15.4, 15.6, 18.9, 19.9, 21.2, 22.4, 25.7, 25.8,
26.4, 26.5, 28.2, 30.8, 30.9, 33.2, 37.7, 38.1, 40.2, 45.4, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3,
73.0, 76.3, 78.4, 78.8, 82.4, 84.5, 103.8, 153.9, 167.7, 169.2, 170.2, 203.9

I-57

MS(FAB):818+(M+H+).HRMS(FAB): calcd for C43H68N3O12 818.4803 found 818.4805
IR(KBr):3447, 3060, 2972, 2937, 2878, 2785, 1809, 1752, 1717, 1653, 1560, 1541, 1495,
1455, 1380, 1361, 1323, 1304, 1283, 1258, 1233, 1219, 1167, 1142, 1109, 1079, 1048,
1005, 992, 953, 932, 893, 861, 834, 800, 776, 751, 700, 622, 580, 564, 512, 490, 457,
434(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.3, 15.4, 15.5, 15.8, 18.8, 18.9, 21.2, 22.4, 26.5,
28.2, 28.6, 29.6, 29.8, 32.7, 33.1, 33.2, 34.6, 38.3, 40.2, 47.5, 47.8, 48.7, 49.7, 51.0, 65.9,
69.5, 70.3, 70.9, 71.4, 76.3, 78.5, 79.4, 82.7, 84.7, 84.8, 103.8, 125.8, 126.1, 128.3, 128.4,
128.5, 140.9, 141.7, 154.4, 165.7, 165.8, 168.7, 168.8, 169.1, 204.0

I-58

MS(FAB):872+(M+H+).HRMS(FAB): calcd for C42H64Cl2N3O12 872.3867 found 872.3873
IR(KBr):3434, 2973, 2938, 2878, 2785, 1811, 1751, 1717, 1673, 1593, 1534, 1456, 1380,
1362, 1323, 1304, 1283, 1258, 1234, 1219, 1167, 1141, 1109, 1078, 1048, 1004, 992, 953,
931, 890, 859, 832, 773, 754, 684, 664, 628, 580, 532, 458, 440(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.2,
30.5, 32.3, 33.1, 38.0, 38.7, 40.2, 47.6, 49.8, 51.1, 65.9, 69.6, 70.3, 73.0, 76.0, 78.5, 78.6,
82.3, 84.6, 103.8, 127.9, 129.6, 130.2, 130.4, 132.1, 142.0, 153.8, 167.7, 169.3, 170.5,
203.9

I-59

MS(FAB):855+(M+H+).HRMS(FAB): calcd for C45H67N4O12 855.4755 found 855.4760
IR(KBr):3433, 2973, 2938, 2877, 2784, 1809, 1751, 1716, 1672, 1621, 1589, 1534, 1490,
1456, 1380, 1322, 1305, 1283, 1234, 1219, 1167, 1142, 1109, 1078, 1047, 1004, 992, 953,
931, 892, 859, 827, 807, 756, 694, 665, 629, 579, 531, 513, 471(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.3,
29.4, 30.0, 33.1, 38.0, 38.9, 40.2, 47.6, 49.8, 51.0, 65.9, 69.5, 70.3, 73.0, 76.0, 78.4, 78.6,
82.3, 84.6, 103.8, 126.0, 127.0, 129.9, 134.5, 137.0, 143.0, 153.1, 153.8, 158.9, 167.6,
169.3, 170.5, 203.9

I-60

MS(FAB):845+(M+H+).HRMS(FAB): calcd for C42H65N6O12 845.4660 found 845.4668
IR(KBr):3428, 2973, 2938, 2878, 2785, 1809, 1751, 1716, 1669, 1585, 1534, 1456, 1417,
1380, 1321, 1304, 1282, 1234, 1167, 1142, 1109, 1078, 1048, 1005, 993, 953, 931, 893,
859, 821, 774, 755, 682, 628, 614, 559, 454, 434(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.3, 15.3, 15.5, 18.8, 19.9, 21.2, 22.2, 25.7, 26.4,
28.2, 28.3, 33.2, 37.8, 37.9, 40.2, 47.6, 49.8, 51.0, 65.9, 69.6, 70.3, 72.6, 75.9, 78.4, 78.6,
82.6, 85.0, 103.8, 141.4, 154.2, 157.0, 158.9, 168.4, 169.5, 172.1, 203.8

I-61

MS(FAB):855+(M+H+).HRMS(FAB): calcd for C45H67N4O12 855.4755 found 855.4744
IR(KBr):3433, 3055, 2973, 2937, 2878, 2784, 1809, 1751, 1716, 1672, 1630, 1591, 1533,
1491, 1455, 1381, 1362, 1323, 1305, 1283, 1257, 1234, 1219, 1167, 1141, 1109, 1078,
1048, 1005, 992, 952, 931, 890, 859, 835, 801, 754, 695, 665, 629, 557, 531, 514,
473(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.3, 15.3, 15.6, 18.9, 19.9, 21.1, 22.3, 26.4, 28.2,
29.4, 33.2, 35.1, 38.1, 38.6, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 73.0, 76.1, 78.4, 78.7,
82.4, 84.6, 103.8, 118.2, 126.2, 126.4, 127.1, 127.4, 130.2, 136.5, 151.9, 153.9, 154.5,
167.5, 169.2, 170.2, 203.9
I-62

MS(FAB):855+(M+H+).HRMS(FAB): calcd for C45H67N4O12 855.4755 found 855.4749
IR(KBr):3433, 2973, 2937, 2878, 2784, 1809, 1751, 1716, 1672, 1594, 1569, 1534, 1501,
1455, 1380, 1322, 1305, 1284, 1257, 1233, 1219, 1167, 1142, 1109, 1079, 1048, 1004,
992, 953, 931, 892, 835, 800, 772, 754, 694, 666, 617, 555, 533, 480, 456(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.2,
30.6, 33.1, 38.0, 38.9, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 73.0, 76.0, 78.4, 78.6, 82.4,
84.6, 103.8, 120.9, 126.2, 128.3, 129.2, 131.0, 135.8, 140.1, 147.1, 149.5, 153.8, 167.6,
169.3, 170.4, 203.9

I-63

MS(FAB):840+(M+H+).HRMS(FAB): calcd for C45H66N3O12 840.4647 found 840.4650
IR(KBr):3432, 3051, 2973, 2937, 2878, 2784, 1811, 1751, 1717, 1676, 1637, 1601, 1529,
1509, 1456, 1380, 1362, 1324, 1304, 1282, 1258, 1233, 1219, 1167, 1142, 1109, 1078,
1048, 1004, 992, 953, 931, 892, 858, 817, 773, 749, 694, 622, 555, 532, 477(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.1, 15.1, 15.5, 18.4, 19.7, 21.0, 22.1, 26.2, 28.0,
33.0, 35.6, 37.9, 39.9, 40.0, 47.5, 49.6, 50.9, 65.7, 69.4, 70.2, 72.8, 76.0, 78.2, 78.7, 82.2,
84.5, 103.6, 125.2, 125.8, 126.9, 127.1, 127.4, 127.5, 128.0, 132.1, 133.4, 136.3, 153.8,
167.3, 169.1, 170.1, 203.8

I-64

MS(FAB):856+(M+H+).HRMS(FAB): calcd for C44H66N5O12 856.4708 found 856.4705
IR(CHCl3):3430, 3352, 3026, 2976, 2938, 2876, 1805, 1751, 1715, 1663, 1616, 1558,
1533, 1496, 1455, 1381, 1361, 1321, 1304, 1282, 1256, 1230, 1220, 1165, 1139, 1106,
1075, 1046, 1003, 989, 950, 930, 891, 655(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.3, 15.3, 15.5, 18.9, 19.9, 21.1, 22.3, 26.4, 27.8,
28.6, 31.5, 33.2, 38.0, 38.7, 40.2, 47.6, 49.8, 51.1, 66.0, 69.3, 70.2, 73.0, 76.1, 78.4, 78.6,
82.4, 84.6, 103.6, 124.0, 124.7, 127.6, 129.0, 133.5, 149.8, 153.9, 154.5, 167.6, 169.2,
170.5, 170.7, 204.0

I-65

MS(FAB):869+(M+H+).HRMS(FAB): calcd for C46H69N4O12 869.4912 found 869.4922
IR(KBr):3437, 2974, 2937, 2878, 2785, 1810, 1751, 1716, 1672, 1618, 1600, 1560, 1529,
1505, 1455, 1428, 1379, 1321, 1284, 1257, 1233, 1167, 1141, 1109, 1081, 1047, 1005,
992, 952, 931, 898, 831, 802, 754, 693, 665, 619, 573, 555, 526, 478, 455, 430(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.6, 16.0, 18.9, 19.9, 21.1, 22.3, 26.3,
28.3, 29.3, 33.1, 36.5, 38.0, 39.1, 40.2, 47.7, 49.8, 51.1, 65.9, 69.5, 70.3, 76.1, 78.5, 78.6,
82.5, 84.6, 103.7, 121.5, 125.6, 126.8, 127.4, 128.9, 129.2, 136.2, 147.9, 153.9, 162.1,
166.2, 169.2, 172.1, 203.9

I-66

MS(FAB):869+(M+H+).HRMS(FAB): calcd for C46H69N4O12 869.4912 found 869.4914
IR(KBr):3435, 2974, 2938, 2878, 2784, 1810, 1751, 1717, 1673, 1591, 1569, 1528, 1509,
1456, 1379, 1322, 1284, 1257, 1235, 1167, 1142, 1109, 1082, 1047, 1005, 992, 952, 931,
902, 835, 813, 801, 757, 694, 665, 631, 573, 532, 454, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.3, 15.2, 15.7, 15.8, 18.8, 19.9, 21.1, 22.2, 26.2,
28.3, 29.2, 33.0, 37.9, 39.1, 40.2, 47.7, 49.7, 51.0, 65.8, 69.5, 70.3, 75.9, 78.3, 78.5, 82.4,
84.7, 103.7, 120.6, 123.6, 126.3, 127.6, 128.9, 130.0, 147.8, 148.2, 150.2, 153.8, 166.3,
169.3, 172.3, 203.8

I-67

MS(FAB):869+(M+H+).HRMS(FAB): calcd for C46H69N4O12 869.4912 found 869.4906
IR(KBr):3436, 2974, 2938, 2877, 2784, 1810, 1751, 1717, 1672, 1623, 1583, 1528, 1456,
1379, 1322, 1283, 1257, 1233, 1167, 1109, 1082, 1047, 1005, 992, 952, 931, 896, 862,
835, 786, 753, 694, 665, 620, 559, 533, 458, 428(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.7, 15.9, 18.9, 19.9, 21.1, 22.3, 26.2,
27.6, 28.2, 30.3, 33.1, 37.9, 39.3, 40.2, 47.7, 49.8, 51.1, 65.9, 69.6, 70.3, 76.0, 78.5, 78.6,
82.4, 84.6, 103.8, 123.0, 126.7, 128.2, 128.4, 130.2, 130.9, 134.7, 142.5, 151.3, 153.8,
166.2, 169.3, 172.2, 203.9
I-68

MS(FAB):840+(M+H+).HRMS(FAB): calcd for C45H66N3O12 840.4647 found 840.4650
IR(KBr):3432, 3046, 2972, 2937, 2878, 2784, 1811, 1751, 1717, 1676, 1596, 1529, 1456,
1380, 1362, 1323, 1304, 1283, 1257, 1234, 1219, 1167, 1142, 1109, 1078, 1048, 1004,
992, 953, 932, 893, 860, 834, 800, 778, 755, 694, 628, 554, 531, 456, 427(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 14.3, 15.3, 15.5, 18.8, 19.8, 21.2, 22.3, 26.3, 28.2,
32.9, 33.2, 38.0, 40.0, 40.2, 47.6, 49.7, 51.1, 65.9, 69.5, 70.3, 73.0, 76.1, 78.4, 78.6, 82.4,
84.6, 103.7, 123.9, 125.5, 125.6, 126.1, 126.6, 127.1, 128.6, 132.1, 133.8, 135.2, 153.9,
158.8, 167.4, 169.2, 170.4, 204.0

I-69

MS(FAB):818+(M+H+).HRMS(FAB): calcd for C43H68N3O12 818.4803 found 818.4799
IR(KBr):3437, 3061, 2971, 2936, 2877, 2785, 1811, 1752, 1717, 1676, 1603, 1534, 1496,
1455, 1380, 1362, 1323, 1304, 1283, 1258, 1233, 1219, 1167, 1142, 1109, 1078, 1048,
1004, 992, 953, 932, 892, 859, 835, 801, 773, 742, 701, 669, 631, 555, 531, 457, 404(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.0, 14.3, 15.4, 15.6, 17.4, 17.5, 18.9, 19.9, 21.1, 22.3,
26.4, 28.2, 33.2, 35.2, 35.3, 38.1, 40.2, 40.9, 41.0, 44.8, 47.6, 47.7, 49.7, 51.1, 65.8, 69.5,
70.3, 73.0, 76.2, 78.4, 78.7, 78.8, 82.4, 84.5, 103.8, 125.8, 128.2, 129.1, 140.3, 153.8,
167.7, 169.2, 170.3, 203.9

I-70

MS(FAB):819+(M+H+).HRMS(FAB): calcd for C42H67N4O12 819.4755 found 819.4762
IR(KBr):3432, 3062, 2972, 2937, 2878, 2786, 1811, 1751, 1686, 1654, 1647, 1637, 1629,
1559, 1541, 1523, 1508, 1497, 1456, 1380, 1362, 1323, 1304, 1283, 1257, 1233, 1219,
1167, 1142, 1109, 1079, 1048, 1004, 993, 953, 932, 892, 859, 834, 800, 773, 751, 700,
669, 629, 555, 515, 454(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.3, 15.4, 15.6, 18.9, 19.9, 21.1, 22.3, 26.4, 28.2,
29.7, 33.1, 34.0, 38.1, 40.2, 46.4, 47.6, 50.0, 51.0, 60.9, 65.9, 69.5, 70.3, 72.6, 76.1, 78.4,
78.9, 82.4, 84.5, 103.8, 125.9, 128.3, 128.7, 139.8, 153.9, 168.3, 168.6, 169.2, 203.9

I-71

MS(FAB):855+(M+H+).HRMS(FAB): calcd for C45H67N4O12 855.4755 found 855.4766
IR(KBr):3434, 2973, 2937, 2878, 2784, 1810, 1751, 1716, 1672, 1625, 1596, 1534, 1503,
1455, 1380, 1363, 1320, 1284, 1257, 1233, 1219, 1167, 1142, 1109, 1079, 1047, 1004,
992, 953, 931, 892, 835, 801, 772, 754, 695, 664, 615, 555, 530, 479, 456(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.5, 18.9, 19.9, 21.1, 22.3, 26.3, 28.2,
30.7, 33.2, 33.4, 33.4, 38.0, 38.8, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 73.0, 76.1, 78.4,
78.7, 82.3, 84.6, 103.7, 120.3, 126.7, 127.6, 127.8, 128.0, 135.6, 143.4, 148.5, 150.2,
153.8, 167.6, 169.2, 170.3, 203.9

I-72

MS(FAB):856+(M+H+).HRMS(FAB): calcd for C44H66N5O12 856.4708 found 856.4714
IR(KBr):3433, 3063, 2972, 2937, 2878, 2784, 1810, 1751, 1716, 1673, 1533, 1491, 1455,
1380, 1363, 1322, 1304, 1284, 1258, 1233, 1219, 1167, 1141, 1109, 1078, 1048, 1005,
992, 953, 931, 893, 859, 835, 801, 762, 695, 666, 628, 611, 557, 532, 456, 409(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.4, 15.5, 18.9, 19.9, 21.1, 22.3, 26.3, 28.2,
28.6, 33.2, 33.5, 38.0, 38.7, 40.2, 47.6, 49.8, 51.0, 65.9, 69.5, 70.3, 73.0, 76.0, 78.4, 78.7,
82.3, 84.6, 103.8, 128.8, 129.0, 129.1, 129.7, 141.3, 142.1, 145.8, 153.8, 156.6, 167.6,
169.2, 170.4, 203.8

I-73

MS(FAB):832+(M+H+).HRMS(FAB): calcd for C44H70N3O12 832.4960 found 832.4955
IR(KBr):3437, 3085, 3061, 2972, 2937, 2878, 2785, 1811, 1751, 1717, 1673, 1527, 1497,
1455, 1380, 1362, 1324, 1304, 1283, 1257, 1233, 1167, 1141, 1109, 1081, 1048, 1005,
990, 954, 932, 912, 863, 835, 801, 771, 750, 700, 669, 631, 575, 555, 533, 455, 430(cm-1)
13C-NMR(CDCl3):δ(ppm)9.6, 10.2, 12.9, 14.3, 15.3, 15.6, 19.0, 19.9, 21.2, 22.3, 23.6, 26.4,
28.2, 30.9, 33.2, 37.9, 38.9, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 76.1, 78.5, 82.3, 83.5,
84.5, 103.7, 125.6, 128.2, 128.4, 141.7, 153.8, 166.6, 169.2, 171.6, 204.0

I-74

MS(FAB):832+(M+H+). HRMS(FAB): calcd for C44H70N3O12 832.4959 found 832.4951
IR(KBr):3439, 3061, 2972, 2937, 2878, 2785, 1811, 1751, 1717, 1671, 1604, 1577, 1525,
1497, 1455, 1380, 1362, 1323, 1305, 1283, 1258, 1233, 1219, 1167, 1142, 1109, 1082,
1048, 1005, 990, 954, 932, 904, 862, 835, 800, 777, 749, 700, 669, 632, 574, 555, 513,
457 (cm-1)
13C-NMR(CDCl3):δ(ppm)9.9, 10.3, 12.9, 14.2, 15.4, 15.6, 18.9, 19.8, 21.1, 22.3, 25.1, 26.3,
28.2, 31.1, 33.1, 33.3, 38.1, 38.7, 40.2, 47.6, 49.7, 51.0, 65.8, 69.5, 70.3, 76.1, 78.3, 78.8,
82.4, 84.5, 84.6, 103.7, 125.7, 128.3, 128.4, 141.6, 153.8, 166.7, 169.1, 172.6, 203.9

I-75

MS(SI):830+(M+H+).HRMS(SI):calcd for C44H68N3O12 830.4799 found 830.4801
IR(KBr):3434, 3060, 2972, 2937, 2878, 2785, 1809, 1751, 1699, 1654, 1646, 1637, 1604,
1496, 1455, 1380, 1362, 1322, 1303, 1284, 1257, 1233, 1219, 1167, 1109, 1083, 1047,
1005, 991, 953, 931, 901, 835, 776, 750, 700, 669, 619, 580, 528, 490, 458, 433, 413(cm-1)
13C-NMR(CDCl3):δ(ppm)10.4, 12.9, 14.3, 15.4, 15.7, 18.9, 19.9, 21.2, 22.4, 25.0, 26.2,
28.2, 28.5, 33.1, 33.3, 38.1, 40.2, 42.8, 45.6, 47.7, 49.8, 51.1, 65.9, 69.5, 70.3, 76.3, 78.5,
78.9, 79.4, 82.7, 84.6, 103.8, 125.8, 128.3, 128.4, 141.6, 154.3, 166.0, 169.2, 171.8, 204.1

I-76

MS(FAB):804+(M+H+). HRMS(FAB): calcd for C43H70N3O11 804.5010 found 804.5004
IR(KBr):3434, 3084, 3061, 3024, 2973, 2937, 2875, 2784, 1810, 1745, 1701, 1654, 1646,
1636, 1603, 1496, 1455, 1403, 1377, 1354, 1335, 1301, 1282, 1257, 1171, 1109, 1083,
1051, 1034, 986, 958, 937, 915, 900, 835, 748, 719, 701, 669, 619, 582, 489(cm-1)
13C-NMR(CDCl3):δ(ppm)10.6, 14.1, 14.5, 14.9, 16.2, 18.6, 19.6, 21.2, 21.6, 24.9, 25.6,
26.4, 26.5, 28.3, 28.7, 33.1, 33.2, 33.3, 37.8, 40.2, 42.6, 42.7, 44.0, 44.1, 46.4, 49.9, 50.0,
50.9, 65.9, 69.4, 70.0, 70.2, 70.3, 73.8, 73.9, 77.6, 77.8, 78.1, 78.2, 78.9, 79.7, 103.4,
126.0, 128.3, 128.4, 141.3, 141.4, 169.4, 170.7, 170.9, 171.0, 171.1, 205.6

I-77

MS(SI):869+(M+H+).HRMS(SI):calcd for C46H69N4O12 869.4908 found 869.4911
IR(KBr):3430, 2973, 2935, 2879, 1805, 1749, 1641, 1457, 1378, 1307, 1257, 1166, 1110,
1078, 1051, 998, 954, 890, 833, 769, 692, 566, 453, 412(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.3, 15.4, 15.5, 15.7, 18.8, 18.9, 19.8, 21.2, 22.4,
26.4, 27.1, 28.3, 28.6, 28.9, 29.2, 33.1, 33.5, 34.8, 38.3, 40.2, 47.6, 47.8, 49.2, 49.7, 51.1,
65.9, 69.5, 70.3, 70.9, 71.2, 76.3, 78.5, 79.3, 82.7, 84.7, 103.8, 120.6, 120.7, 123.2, 123.4,
126.4, 126.6, 127.3, 127.5, 129.0, 129.2, 130.2, 130.3, 147.0, 147.6, 148.3, 148.4, 150.3,
154.4, 165.9, 166.0, 168.9, 169.0, 169.1, 169.2, 203.9

I-78

MS(FAB):869+(M+H+). HRMS(FAB): calcd for C46H69N4O12 869.4912 found 869.4921
IR(KBr):3436, 2974, 2937, 2878, 2784, 1810, 1751, 1716, 1672, 1625, 1596, 1529, 1503,
1455, 1379, 1320, 1284, 1257, 1234, 1167, 1142, 1109, 1082, 1047, 1005, 992, 952, 931,
897, 835, 801, 772, 754, 694, 663, 615, 573, 555, 530, 479, 456(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.6, 16.0, 18.9, 19.9, 21.1, 22.3, 26.3,
28.2, 30.6, 33.1, 33.5, 37.9, 39.0, 40.2, 47.6, 49.8, 51.1, 65.8, 69.5, 70.3, 76.0, 78.5, 78.6,
82.5, 84.6, 103.7, 120.3, 126.7, 127.6, 127.9, 128.0, 135.7, 143.6, 148.5, 150.2, 153.9,
166.3, 169.2, 172.1, 203.9

I-79

MS(FAB):870+(M+H+). HRMS(FAB): calcd for C45H68N5O12 870.4865 found 870.4869
IR(KBr):3434, 2973, 2936, 2878, 2785, 1811, 1751, 1716, 1673, 1617, 1568, 1558, 1529,
1497, 1455, 1380, 1322, 1283, 1257, 1234, 1167, 1109, 1082, 1047, 1005, 992, 952, 932,
899, 835, 770, 693, 680, 624, 573, 512, 459(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.6, 15.9, 18.9, 19.9, 21.1, 22.3, 26.2,
27.9, 28.4, 31.7, 33.1, 37.9, 39.0, 40.1, 47.6, 49.8, 51.1, 65.9, 69.4, 70.3, 76.0, 78.5, 78.6,
82.5, 84.6, 103.7, 124.0, 124.8, 127.5, 129.0, 133.4, 149.7, 153.8, 154.5, 166.3, 169.2,
170.9, 172.3, 203.9

I-80

MS(FAB):870+(M+H+). HRMS(FAB): calcd for C45H68N5O12 870.4864 found 870.4874
IR(KBr):3435, 3062, 2974, 2937, 2878, 2784, 1811, 1751, 1716, 1672, 1530, 1492, 1455,
1410, 1364, 1322, 1284, 1257, 1234, 1167, 1141, 1109, 1082, 1047, 1005, 992, 952, 931,
899, 835, 801, 762, 694, 665, 631, 610, 573, 556, 532, 457, 409(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 12.8, 14.3, 15.3, 15.6, 15.8, 18.8, 19.9, 21.1, 22.2, 26.2,
28.3, 28.6, 33.0, 33.7, 37.9, 38.9, 40.2, 47.6, 49.8, 51.0, 65.8, 69.4, 70.3, 75.9, 78.4, 78.5,
78.6, 82.4, 84.6, 103.7, 128.7, 129.0, 129.1, 129.7, 141.2, 142.2, 145.9, 153.8, 156.8,
166.3, 169.2, 172.2, 203.8

I-81

MS(SI):883+(M+H+).HRMS(SI):calcd for C47H71N4O12 883.5065 found 883.5069
IR(KBr):3435, 2971, 2937, 2877, 2784, 1810, 1751, 1716, 1673, 1592, 1569, 1526, 1509,
1456, 1380, 1362, 1323, 1305, 1284, 1257, 1233, 1167, 1141, 1109, 1082, 1047, 1005,
990, 954, 932, 912, 835, 813, 800, 764, 694, 631, 574, 515, 454, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)9.8, 10.3, 12.8, 14.3, 15.2, 15.6, 18.9, 19.9, 21.1, 22.2, 23.5, 26.3,
28.2, 29.3, 29.4, 33.1, 37.8, 39.0, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 76.0, 78.5, 78.6,
82.3, 83.4, 84.6, 103.7, 120.6, 123.6, 126.3, 127.6, 128.9, 130.1, 147.8, 148.2, 150.3,
153.9, 166.8, 169.3, 171.9, 203.9

I-82

MS(SI):883+(M+H+).HRMS(SI):calcd for C47H73N4O12 883.5065 found 883.5068
IR(KBr):3437, 2971, 2937, 2877, 2784, 1810, 1751, 1716, 1673, 1625, 1596, 1526, 1504,
1455, 1380, 1363, 1321, 1284, 1257, 1232, 1167, 1142, 1109, 1081, 1047, 1005, 990, 953,
932, 912, 835, 801, 772, 693, 660, 633, 615, 574, 555, 531, 478, 457(cm-1)
13C-NMR(CDCl3):δ(ppm)9.7, 10.2, 12.9, 14.3, 15.3, 15.6, 19.0, 19.9, 21.1, 22.3, 23.7, 26.4,
28.3, 30.8, 33.2, 33.5, 37.9, 38.9, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 76.1, 78.5, 78.6,
82.3, 83.5, 84.6, 103.8, 120.3, 126.7, 127.6, 127.9, 128.1, 135.7, 143.6, 148.6, 150.2,
153.9, 166.7, 169.3, 171.7, 204.0

I-83

MS(FAB):846+(M+H+). HRMS(FAB): calcd for C45H72N3O12 846.5116 found 846.5109
IR(KBr):3436, 3061, 2965, 2930, 2874, 2854, 2785, 1810, 1750, 1717, 1671, 1527, 1496,
1455, 1381, 1323, 1304, 1284, 1257, 1233, 1219, 1167, 1141, 1109, 1079, 1047, 1007,
992, 954, 931, 913, 862, 835, 800, 777, 750, 699, 668, 577, 529, 456, 419(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.0, 14.3, 15.2, 15.4, 17.0, 19.0, 19.5, 19.9, 21.2, 22.4,
26.5, 28.4, 29.5, 29.7, 31.2, 33.2, 37.9, 38.9, 40.2, 47.5, 49.8, 51.2, 66.0, 69.5, 70.3, 76.3,
78.3, 78.6, 82.2, 84.6, 87.2, 103.6, 125.7, 128.3, 128.4, 141.7, 153.9, 166.9, 169.2, 171.6,
204.1

I-84

MS(FAB):846+(M+H+). HRMS(FAB): calcd for C45H72N3O12 846.5116 found 846.5114
IR(KBr):3438, 3061, 2970, 2936, 2875, 1811, 1751, 1717, 1670, 1524, 1497, 1455, 1381,
1323, 1305, 1283, 1257, 1233, 1219, 1167, 1142, 1109, 1079, 1048, 1006, 992, 954, 931,
910, 862, 835, 800, 776, 750, 700, 633, 579, 555, 513, 456(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.0, 14.3, 15.4, 15.5, 18.4, 18.8, 19.0, 19.9, 21.2, 22.4,
26.3, 28.3, 30.4, 31.2, 33.3, 33.4, 38.2, 38.7, 40.2, 47.6, 49.8, 51.1, 66.0, 69.5, 70.4, 76.2,
78.4, 78.8, 82.4, 84.6, 89.0, 103.8, 125.8, 128.3, 128.4, 141.7, 153.9, 166.2, 169.2, 172.0,
203.9

I-85

MS(FAB):862+(M+H+). HRMS(FAB): calcd for C44H68N3O14 862.4701 found 862.4702
IR(KBr):3435, 2973, 2937, 2877, 2784, 1811, 1751, 1717, 1674, 1590, 1532, 1508, 1456,
1380, 1362, 1305, 1285, 1259, 1238, 1219, 1205, 1167, 1109, 1071, 1048, 1004, 993, 953,
931, 917, 887, 834, 809, 773, 754, 694, 627, 554, 458, 419(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.3, 15.4, 15.5, 18.9, 19.9, 21.2, 22.3, 26.4, 28.3,
31.0, 32.4, 33.3, 38.1, 38.7, 40.2, 47.6, 49.8, 51.1, 64.3, 64.4, 65.9, 69.6, 70.4, 73.1, 76.2,
78.5, 78.7, 82.4, 84.6, 103.8, 117.0, 117.1, 121.2, 134.9, 141.7, 143.3, 153.8, 167.5, 169.2,
170.2, 204.0

I-86

MS(FAB):848+(M+H+). HRMS(FAB): calcd for C43H66N3O14 848.4545 found 848.4553
IR(KBr):3434, 2972, 2937, 2879, 2784, 1811, 1751, 1716, 1673, 1533, 1504, 1489, 1455,
1380, 1363, 1323, 1304, 1283, 1244, 1167, 1141, 1109, 1078, 1046, 1004, 993, 953, 930,
893, 859, 834, 808, 773, 755,682, 630, 556, 531, 454, 426(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.3, 15.4, 15.5, 18.9, 19.9, 21.2, 22.4, 26.4, 28.3,
31.2, 32.9, 33.3, 38.1, 38.7, 40.2, 47.6, 49.8, 51.1, 66.0, 69.6, 70.4, 73.1, 76.2, 78.5, 78.7,
82.4, 84.6, 100.6, 103.8, 108.1, 108.9, 121.1, 135.5, 145.6, 147.6, 153.8, 167.6, 169.3,
170.3, 203.9

I-87

MS(FAB):886+(M+H+). HRMS(FAB): calcd for C45H68N5O13 886.4814 found 886.4812
IR(KBr):3435, 3069, 2974, 2937, 2879, 2786, 1810, 1751, 1681, 1616, 1533, 1489, 1456,
1380, 1325, 1283, 1249, 1234, 1166, 1109, 1081, 1047, 1005, 993, 952, 931, 916, 899,
837, 799, 775, 754, 682, 630, 581, 534, 512, 458, 428, 406(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.7, 15.9, 18.8, 19.9, 21.1, 22.2, 26.2,
28.5, 30.7, 33.0, 37.9, 38.9, 40.0, 47.7, 49.8, 51.1, 65.8, 69.3, 70.3, 76.0, 78.4, 78.5, 78.6,
82.5, 84.7, 103.6, 122.4, 125.3, 127.5, 135.5, 141.5, 143.4, 147.3, 153.9, 163.0, 166.4,
169.3, 172.3, 203.9

I-88

MS(SI):901+(M+H+).HRMS(SI):calcd for C46H69N4O14 901.4806 found 901.4811
IR(KBr):3437, 2974, 2938, 2878, 2785, 1812, 1751, 1714, 1675, 1621, 1529, 1455, 1380,
1323, 1283, 1253, 1234, 1220, 1167, 1141, 1109, 1082, 1047, 1006, 993, 952, 931, 902,
835, 774, 743, 691, 607, 558, 529, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.3, 15.3, 15.7, 15.8, 18.9, 19.9, 21.2, 22.2, 23.8,
26.2, 28.2, 30.6, 33.0, 33.6, 37.9, 38.7, 40.2, 47.7, 49.8, 51.1, 65.9, 69.6, 70.3, 75.9, 78.3,
78.5, 78.6, 82.4, 84.6, 103.8, 123.1, 123.2, 129.9, 132.6, 133.9, 149.3, 153.8, 166.3, 168.6,
169.3, 172.2, 203.8

I-89

MS(SI):884+(M+H+).HRMS(SI):calcd for C46H70N5O12 884.5017 found 884.5020
IR(KBr):3435, 2971, 2937, 2878, 2784, 1810, 1751, 1717, 1671, 1637, 1527, 1499, 1456,
1379, 1324, 1304, 1284, 1257, 1233, 1218, 1167, 1140, 1109, 1080, 1048, 1005, 990, 956,
931, 912, 866, 831, 772, 755, 693, 557, 459, 407(cm-1)
13C-NMR(CDCl3):δ(ppm)9.8, 10.2, 12.9, 14.3, 15.3, 15.6, 15.7, 18.9, 19.9, 21.2, 22.2, 23.6,
26.4, 28.2, 30.6, 33.1, 33.4, 37.8, 38.8, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 76.0, 78.5,
82.3, 83.4, 84.6, 84.7, 103.8, 127.8, 129.1, 131.7, 141.8, 143.2, 144.1, 144.5, 144.8, 153.8,
153.9, 166.8, 169.3, 171.9, 204.0

I-90

MS(FAB):886+(M+H+). HRMS(FAB): calcd for C45H68N5O13 886.4814 found 886.4807
IR(KBr):3435, 2974, 2938, 2879, 2786, 1811, 1751, 1676, 1622, 1528, 1456, 1379, 1322,
1284, 1257, 1234, 1166, 1142, 1109, 1081, 1047, 1005, 992, 951, 902, 834, 773, 682, 609,
574, 506, 472, 429, 404(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.2, 15.3, 15.7, 16.0, 18.8, 19.9, 21.1, 22.2, 26.2,
28.2, 30.3, 33.0, 33.1, 37.9, 38.9, 40.2, 47.9, 49.9, 51.2, 65.8, 69.5, 70.3, 76.1, 78.3, 78.5,
82.5, 84.7, 103.7, 114.9, 125.0, 129.1, 131.2, 131.6, 145.9, 149.7, 153.9, 156.3, 166.4,
169.8, 172.3, 203.7

I-91

MS(SI):930+(M+H+).HRMS(SI):calcd for C47H72N5O14 9305071 found 930.5068
IR(KBr):3437, 2974, 2937, 2878, 2784, 1809, 1751, 1716, 1670, 1638, 1612, 1530, 1498,
1455, 1362, 1323, 1284, 1258, 1234, 1167, 1140, 1109, 1082, 1047, 1005, 993, 952, 931,
901, 835, 754, 725, 682, 616, 573, 555, 513, 435(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.7, 15.8, 18.9, 19.9, 21.2, 22.2, 26.2,
28.2, 30.6, 33.0, 33.1, 33.2, 33.4, 37.9, 38.8, 40.2, 47.7, 49.8, 51.1, 65.9, 69.5, 70.3, 76.0,
78.4, 78.5, 78.6, 82.4, 84.6, 103.7, 126.7, 127.0, 127.7, 128.8, 133.8, 148.3, 153.8, 158.0,
166.3, 169.3, 172.2, 203.9

I-92

MS(FAB):870+(M+H+). HRMS(FAB): calcd for C45H68N5O12 870.4864 found 870.4877
IR(CHCl3):3422, 3348, 3020, 2972, 2934, 2870, 1804, 1750, 1714, 1661, 1573, 1534,
1495, 1454, 1379, 1309, 1283, 1255, 1233, 1219, 1165, 1107, 1082, 1045, 1006, 990, 949,
930, 909, 838, 664, 560, 529, 508, 501(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.3, 15.3, 15.6, 15.7, 18.9, 19.9, 21.2, 22.2, 26.2,
28.3, 30.4, 33.0, 33.3, 37.9, 39.0, 40.2, 47.7, 49.8, 51.1, 65.9, 69.5, 70.3, 75.9, 78.3, 78.5,
78.6, 82.5, 84.7, 103.7, 125.2, 125.4, 128.1, 136.0, 142.2, 148.9, 153.9, 154.6, 159.9,
166.3, 169.4, 172.3, 203.8

I-93

MS(SI):872+(M+H+).HRMS(SI):calcd for C44H66N5O13 872.4653 found 872.4656
IR(KBr):3432, 2973, 2937, 2879, 2785, 1811, 1752, 1701, 1654, 1636, 1623, 1499, 1456,
1367, 1322, 1304, 1284, 1258, 1233, 1219, 1167, 1141, 1108, 1082, 1047, 1005, 992, 954,
931, 916, 893, 866, 833, 804, 774, 754, 694, 667, 630, 568, 526, 451, 408(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.0, 15.4, 15.5, 18.7, 19.8, 21.2, 22.3, 26.2,
28.3, 33.0, 34.7, 38.0, 40.2, 47.5, 49.8, 51.0, 65.9, 69.5, 70.3, 75.9, 76.0, 77.2, 78.1, 78.3,
82.5, 84.7, 103.6, 128.7, 129.2, 132.0, 141.2, 141.9, 143.1, 144.2, 144.8, 153.7, 166.7,
169.1, 169.8, 204.0

I-94

MS(SI):862+(M+H+).HRMS(SI):calcd for C44H68N3O14 862.4698 found 862.4699
IR(KBr):3438, 2973, 2937, 2878, 2784, 1811, 1751, 1717, 1673, 1529, 1504, 1489, 1455,
1379, 1364, 1323, 1284, 1244, 1167, 1141, 1109, 1082, 1046, 1005, 992, 951, 933, 862,
834, 808, 773, 755, 693, 633, 573, 555, 514, 455, 418(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.4, 15.7, 15.9, 18.9, 19.9, 21.2, 22.3,
26.3, 28.2, 31.1, 33.0, 33.1, 38.0, 38.9, 40.2, 47.7, 49.8, 51.1, 65.9, 69.5, 70.3, 76.1, 78.5,
78.6, 82.5, 84.6, 100.6, 103.8, 108.0, 108.9, 121.1, 135.6, 145.5, 147.5, 153.8, 166.3,
169.2, 172.1, 203.9

I-95

MS(SI):864+(M+H+).HRMS(SI):calcd for C44H70N3O14 864.4853 found 864.4850
IR(KBr):3434, 2971, 2937, 2878, 2784, 1811, 1751, 1717, 1674, 1609, 1590, 1515, 1455,
1418, 1380, 1362, 1324, 1304, 1261, 1235, 1159, 1141, 1109, 1078, 1047, 1004, 993, 953,
931, 892, 859, 835, 803, 772, 694, 630, 556, 532, 456(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.6, 18.9, 19.9, 21.1, 22.3, 26.3, 28.2,
31.1, 32.8, 33.1, 38.0, 38.8, 40.2, 47.6, 49.8, 51.0, 55.8, 55.9, 65.9, 69.5, 70.3, 73.0, 76.1,
78.4, 78.7, 82.4, 84.6, 103.8, 111.2, 111.7, 120.1, 134.3, 147.1, 148.8, 153.8, 167.6, 169.2,
170.4, 203.9

I-96

MS(FAB):870+(M+H+). HRMS(FAB): calcd for C45H68N5O12 870.4864 found 870.4865
IR(KBr):3435, 2974, 2938, 2878, 2784, 1810, 1751, 1716, 1673, 1599, 1529, 1495, 1456,
1414, 1378, 1322, 1304, 1284, 1257, 1233, 1220, 1167, 1141, 1109, 1081, 1047, 1005,
992, 952, 931, 902, 856, 802, 774, 755, 693, 641, 571, 517, 482, 454, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.7, 15.9, 18.9, 19.9, 21.1, 22.3, 26.3,
28.3, 29.0, 33.1, 36.4, 37.9, 38.9, 40.2, 47.7, 49.8, 51.1, 65.9, 69.5, 70.3, 76.0, 78.5, 78.6,
82.5, 84.6, 103.7, 119.7, 125.8, 129.8, 134.7, 143.0, 153.7, 153.9, 164.1, 166.3, 169.2,
172.2, 203.9

I-97

MS(SI):870+(M+H+).HRMS(SI):calcd for C45H68N5O12 870.4860 found 870.4860
IR(KBr):3434, 2973, 2937, 2877, 2784, 1809, 1750, 1717, 1673, 1636, 1625, 1577, 1559,
1527, 1489, 1456, 1380, 1324, 1304, 1283, 1257, 1233, 1166, 1109, 1081, 1047, 1005,
993, 952, 929, 833, 774, 693, 655, 630, 575, 474(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.3, 15.3, 15.6, 15.8, 18.8, 19.9, 21.2, 22.2, 26.2,
28.3, 30.3, 32.9, 33.7, 37.9, 38.9, 40.2, 47.8, 49.8, 51.1, 65.9, 69.5, 70.3, 75.9, 78.3, 78.5,
82.5, 84.7, 103.8, 124.8, 125.1, 126.1, 126.9, 134.2, 147.6, 150.7, 151.1, 153.9, 166.4,
169.4, 172.3, 203.8

I-98

MS(SI):888+(M+H+).HRMS(SI):calcd for C46H70N3O14 888.4854 found 888.4860
IR(KBr):3435, 2972, 2933, 1808, 1749, 1632, 1537, 1493, 1455, 1380, 1321, 1288, 1256,
1220, 1166, 1139, 1109, 1082, 1047, 1006, 993, 952, 831, 560, 414(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.7, 15.9, 18.9, 19.9, 21.2, 22.3, 26.2,
28.3, 30.8, 32.2, 33.1, 37.8, 37.9, 38.8, 40.2, 47.7, 49.8, 51.1, 65.9, 66.9, 69.5, 70.3, 76.0,
78.4, 78.6, 82.4, 84.6, 103.7, 117.8, 121.0, 126.2, 134.9, 136.4, 153.8, 160.2, 166.2, 169.2,
172.1, 191.9, 203.9

I-99

MS(FAB):859+(M+H+). HRMS(FAB): calcd for C43H67N6O12 859.4817 found 859.4808
IR(KBr):3433, 2975, 2938, 2879, 2788, 1809, 1751, 1716, 1668, 1535, 1455, 1380, 1322,
1284, 1259, 1234, 1215, 1167, 1141, 1109, 1081, 1047, 1005, 993, 952, 901, 806, 754,
694, 665, 630, 574, 533, 430, 403(cm-1)
13C-NMR(CD3OD):δ(ppm)10.7, 13.2, 14.7, 15.9, 16.0, 16.9, 19.0, 20.9, 21.3, 23.3, 27.6,
31.6, 32.2, 34.3, 34.4, 38.9, 40.0, 40.5, 48.8, 49.8, 50.4, 66.1, 70.0, 71.7, 77.4, 79.2, 79.4,
79.8, 84.3, 86.4, 104.7, 113.5, 116.3, 128.2, 128.7, 129.5, 129.6, 139.4, 140.4, 142.0,
155.8, 168.0, 171.0, 174.5, 206.2

I-100

MS(FAB):858+(M+H+). HRMS(FAB): calcd for C44H68N5O12 858.4864 found 858.4857
IR(KBr):3433, 2975, 2937, 2879, 1807, 1750, 1670, 1577, 1455, 1381, 1321, 1285, 1237,
1164, 1140, 1110, 1082, 1047, 1005, 952, 895, 803, 774, 756, 692, 621, 572, 529,
431(cm-1)
13C-NMR(CD3OD):δ(ppm)10.7, 13.2, 14.7, 15.9, 16.0, 16.9, 19.0, 20.9, 21.3, 23.4, 27.7,
31.5, 32.6, 34.4, 34.5, 37.9, 39.0, 40.1, 40.4, 49.2, 50.2, 50.4, 66.3, 69.9, 71.4, 77.6, 79.2,
79.8, 84.4, 86.4, 104.6, 115.0, 116.6, 124.7, 138.0, 155.9, 168.0, 171.0, 174.4, 206.3

I-101

MS(SI):858+(M+H+).HRMS(SI):calcd for C45H68N3O13 858.4748 found 858.4751
IR(KBr):3435, 2973, 2936, 2877, 2785, 1811, 1751, 1716, 1672, 1532, 1513, 1456, 1379,
1323, 1305, 1284, 1258, 1235, 1196, 1167, 1141, 1109, 1082, 1047, 1005, 992, 952, 931,
902, 885, 832, 806, 772, 737, 694, 632, 555, 532, 456, 427(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 12.9, 14.3, 15.3, 15.7, 15.9, 18.9, 19.9, 21.1, 22.3, 26.2,
28.2, 31.4, 33.1, 33.2, 37.9, 39.1, 40.2, 47.7, 49.8, 51.1, 65.9, 69.5, 70.3, 76.1, 78.4, 78.5,
78.6, 82.5, 84.5, 103.7, 106.5, 110.9, 120.5, 125.0, 127.4, 136.2, 144.8, 153.6, 153.9,
166.2, 169.2, 172.0, 203.9

I-102

MS(SI):886+(M+H+).HRMS(SI):calcd for C46H68N3O14 886.4698 found 886.4698
IR(KBr):3434, 2972, 2935, 2877, 2786, 1809, 1750, 1716, 1656, 1619, 1570, 1532, 1482,
1455, 1379, 1316, 1285, 1257, 1235, 1167, 1139, 1109, 1081, 1047, 1005, 993, 952, 932,
900, 863, 833, 802, 773, 755, 693, 628, 581, 556, 518, 453(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.7, 15.9, 18.9, 19.9, 21.1, 22.3, 26.2,
28.4, 30.9, 32.6, 33.1, 37.9, 38.8, 40.2, 47.7, 49.8, 51.1, 66.0, 69.4, 70.3, 76.0, 78.5, 78.6,
82.4, 84.6, 103.7, 112.8, 118.1, 124.6, 124.7, 134.5, 139.3, 153.9, 155.1, 166.3, 169.3,
172.2, 177.7, 203.9

I-103

MS(FAB):856+(M+H+). HRMS(FAB): calcd for C44H66N5O12 856.4708 found 856.4716
IR(KBr):3434, 2972, 2937, 2878, 2784, 1810, 1751, 1716, 1673, 1619, 1533, 1498, 1455,
1365, 1323, 1304, 1284, 1257, 1233, 1218, 1167, 1141, 1109, 1078, 1048, 1004, 992, 955,
931, 893, 831, 773, 755, 664, 628, 556, 513, 457, 407(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.6, 18.9, 19.9, 21.1, 22.2, 26.3, 28.2,
30.5, 33.2, 33.3, 38.0, 38.8, 40.2, 47.6, 49.8, 51.1, 65.9, 69.6, 70.3, 73.0, 76.0, 78.5, 78.6,
82.3, 84.6, 103.8, 127.8, 129.2, 131.6, 141.8, 143.2, 144.1, 144.4, 144.8, 153.8, 167.7,
169.3, 170.5, 203.9

I-104

MS(SI):870+(M+H+).HRMS(SI):calcd for C45H68N5O12 870.4861 found 870.4863
IR(KBr):3436, 2974, 2937, 2878, 2784, 1810, 1751, 1716, 1671, 1620, 1529, 1499, 1455,
1367, 1321, 1284, 1257, 1233, 1218, 1167, 1141, 1109, 1082, 1047, 1005, 992, 954, 931,
897, 866, 832, 773, 755, 694, 664, 631, 572, 512, 456, 432, 408(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.0, 14.3, 15.5, 15.6, 17.6, 18.8, 19.8, 21.2, 22.3, 26.3,
28.3, 30.7, 33.3, 38.1, 38.6, 40.2, 47.7, 49.7, 51.1, 65.9, 69.5, 70.3, 76.2, 78.4, 78.8, 79.2,
82.5, 84.6, 103.8, 127.8, 129.2, 131.7, 141.8, 143.2, 144.2, 144.4, 144.9, 154.0, 166.9,
169.2, 173.1, 203.9

I-105

MS(SI):870+(M+H+).HRMS(SI):calcd for C45H68N5O12 870.4861 found 870.4862
IR(KBr):3435, 2972, 2937, 2878, 2784, 1808, 1751, 1716, 1651, 1541, 1498, 1455, 1379,
1323, 1305, 1284, 1257, 1233, 1218, 1167, 1141, 1109, 1078, 1048, 1005, 993, 955, 931,
894, 866, 832, 777, 755, 692, 666, 623, 582, 564, 514, 456, 408(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.3, 15.4, 15.5, 15.7, 18.8, 18.9, 19.8, 21.2, 22.4,
26.5, 28.2, 32.9, 33.2, 33.4, 34.8, 38.3, 40.2, 47.5, 47.8, 49.0, 49.6, 49.7, 51.1, 65.9, 69.5,
70.3, 70.9, 71.2, 76.3, 78.5, 79.3, 82.7, 84.7, 103.8, 127.7, 127.8, 129.3, 1296, 131.4,
131.6, 141.8, 141.9, 143.7, 144.2, 144.4, 144.5, 144.9, 145.1, 154.4, 165.9, 166.0, 168.9,
169.0, 169.1, 204.0

I-106

MS(SI):884+(M+H+).HRMS(SI):calcd for C46H70N5O12 884.5016 found 884.5015
IR(KBr):3443, 2974, 2937, 2878, 2785, 1808, 1752, 1716, 1651, 1498, 1455, 1369, 1322,
1305, 1284, 1257, 1233, 1219, 1167, 1141, 1109, 1082, 1047, 1005, 993, 955, 931, 895,
866, 831, 775, 692, 665, 621, 512, 453, 407(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 10.4, 13.0, 14.2, 15.5, 15.9, 16.5, 16.7, 18.8, 18.9, 19.9,
21.1, 21.2, 22.4, 22.5, 25.9, 26.0, 28.1, 28.3, 30.3, 33.0, 33.3, 34.0, 35.6, 38.1, 40.2, 47.9,
49.3, 49.4, 49.5, 51.1, 65.9, 69.4, 70.4, 73.5, 73.8, 76.1, 76.2, 78.4, 79.1, 82.5, 84.5, 103.7,
127.7, 127.8, 129.2, 129.3, 131.6, 141.8, 143.2, 144.1, 144.3, 144.6, 144.8, 144.9, 154.4,
164.5, 164.9, 168.9, 169.1, 171.2, 203.9

I-107

MS(FAB):700+(M+H+). HRMS(FAB): calcd for C34H58N3O12 700.4020 found 700.4016
IR(KBr):3485, 2975, 2938, 2879, 2840, 2785, 1812, 1751, 1694, 1633, 1589, 1456, 1380,
1322, 1284, 1257, 1233, 1219, 1167, 1142, 1110, 1082, 1047, 1005, 992, 951, 894, 862,
835, 801, 774, 755, 693, 625, 530(cm-1)
13C-NMR(CDCl3):δ(ppm)10.4, 12.9, 14.3, 15.3, 15.5, 15.8, 18.9, 19.9, 21.2, 22.4, 26.2,
28.3, 33.1, 37.9, 40.2, 47.5, 49.7, 51.1, 65.9, 69.5, 70.3, 76.2, 78.2, 78.3, 78.5, 82.5, 84.7,
103.7, 154.0,166.4, 169.3, 174.7, 204.1

I-108

MS(FAB):890+(M+H+). HRMS(FAB): calcd for C44H68N5O12S 890.4585 found 890.4586
IR(KBr):3435, 2974, 2937, 2877, 2784, 1750, 1716, 1673, 1620, 1528, 1499, 1455, 1376,
1322, 1279, 1257, 1217, 1162, 1143, 1107, 1078, 1051, 1032, 991, 945, 899, 866, 828,
765, 707, 684, 641, 609, 553, 512, 472, 424, 408(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 10.5, 14.3, 14.4, 14.5, 15.9, 16.5, 19.1, 19.9, 21.0, 21.2,
22.1, 22.4, 26.2, 28.3, 30.9, 31.0, 32.6, 33.3, 33.4, 33.5, 37.7, 38.2, 38.8, 39.0, 40.2, 47.1,
47.9, 49.9, 51.1, 51.3, 65.0, 65.9, 69.5, 70.3, 76.5, 77.2, 77.9, 78.3, 78.4, 78.6, 78.8, 90.5,
90.6, 103.5, 103.9, 127.8, 127.9, 129.1, 129.3, 131.6, 131.8, 141.8, 143.2, 144.0, 144.2,
144.3, 144.6, 144.7, 144.9, 166.6, 166.9, 169.2, 169.3, 171.1, 172.7, 172.8, 203.9

I-109

MS(FAB):844+(M+H+). HRMS(FAB): calcd for C44H70N5O11 844.5072 found 844.5065
IR(CHCl3):3422, 2972, 2932, 2868, 2828, 1740, 1711, 1669, 1523, 1499, 1453, 1403,
1375, 1333, 1279, 1255, 1219, 1175, 1140, 1107, 1082, 1049, 1031, 983, 955, 906, 864,
786, 667, 558, 541, 533, 529, 522, 518, 510, 505(cm-1)
13C-NMR(CDCl3):δ(ppm)10.5, 13.6, 14.7, 14.9, 16.3, 17.5, 18.9, 19.8, 21.2, 21.5, 26.6,
28.5, 30.9, 33.3, 33.4, 37.5, 38.7, 40.2, 45.9, 50.0, 50.9, 66.0, 69.3, 70.2, 70.3, 73.8, 78.3,
78.4, 79.1, 103.2, 127.9, 129.2, 131.6, 141.8, 143.1, 144.2, 144.3, 144.9, 169.7, 172.4,
172.9, 205.9

I-110

MS(SI):872+(M+H+).HRMS(SI):calcd for C44H66N5O13 872.4653 found 872.4649
IR(KBr):3439, 2974, 2937, 2879, 2784, 1810, 1751, 1716, 1680, 1609, 1575, 1524, 1495,
1457, 1378, 1360, 1322, 1299, 1261, 1223, 1164, 1141, 1107, 1083, 1047, 1005, 992, 952,
931, 895, 862, 830, 801, 757, 728, 693, 631, 573, 555, 514, 456, 432(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.5, 16.0, 18.8, 19.8, 21.2, 22.2, 26.3,
28.2, 33.1, 37.9, 38.1, 40.2, 47.5, 49.8, 51.0, 65.9, 67.3, 69.5, 70.3, 75.9, 78.3, 78.4, 82.4,
84.7, 103.7, 109.7, 121.3, 130.3, 135.4, 143.4, 144.0, 145.1, 153.9, 154.3, 166.5, 169.0,
172.8, 204.0

I-111

MS(FAB):858+(M+H+). HRMS(FAB): calcd for C45H72N5O11 858.5228 found 858.5220
Anal Calcd for C45H67N5O12(H2O)0.6 :C 62.21, H 8.38, N 8.06 Found C 62.25, H 8.29, N
7.98
IR(KBr):3433, 2971, 2937, 2876, 2837, 2784, 1744, 1712, 1682, 1619, 1527, 1498, 1455,
1377, 1336, 1300, 1259, 1181, 1107, 1093, 1075, 988, 957, 938, 891, 870, 833, 799, 697,
665, 632, 617, 583, 555, 510, 408(cm-1)
13C-NMR(CDCl3):δ(ppm)10.5, 14.3, 14.5, 14.9, 15.9, 19.6, 20.6, 21.2, 22.2, 27.9, 28.2,
29.2, 31.0, 33.1, 37.8, 38.4, 40.2, 46.9, 50.1, 51.4, 53.5, 53.9, 61.4, 65.9, 69.5. 70.2, 72.7,
77.8, 79.0, 80.3, 80.8, 104.1, 127.7, 129.3, 131.5, 141.8, 143.1, 144.0, 144.3, 145.0, 169.2,
170.2, 170.7, 204.0

I-112

MS(FAB):819+(M+H+). HRMS(FAB): calcd for C42H67N4O12 819.4755 found 819.4755
IR(KBr):3437, 3061, 2974, 2938, 2878, 2785, 1811, 1751, 1716, 1672, 1496, 1455, 1379,
1322, 1283, 1257, 1233, 1166, 1141, 1110, 1082, 1047, 1005, 992, 953, 930, 916, 892,
835, 801, 774, 749, 700, 631, 572, 555, 532, 457, 432, 404(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.0, 14.3, 15.4, 16.1, 18.9, 19.9, 21.2, 22.4, 26.3, 28.2,
33.2, 34.5, 38.0, 40.2, 47.5, 49.8, 51.1, 53.0, 65.9, 69.6, 70.3, 76.2, 77.9, 78.2, 78.4, 82.5,
84.5, 103.7, 126.0, 128.3, 128.7, 139.7, 153.9, 166.6, 169.1, 171.2, 204.2

I-113

MS(SI):833+(M+H+).HRMS(SI):calcd for C43H69N4O12 833.4907 found 833.4901
IR(KBr):3433, 3060, 2974, 2937, 2878, 2786, 1812, 1752, 1690, 1636, 1559, 1521, 1496,
1455, 1380, 1322, 1283, 1257, 1233, 1166, 1142, 1109, 1082, 1047, 1005, 993, 953, 930,
916, 895, 835, 773, 750, 700, 631, 555, 512, 455, 414(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.3, 15.4, 15.6, 16.5, 19.0, 20.0, 21.2, 22.3, 26.4,
28.2, 33.1, 34.0, 38.0, 40.2, 46.1, 47.7, 50.1, 51.1, 60.8, 65.9, 69.6, 70.3, 76.2, 78.3, 78.4,
78.8, 82.4, 84.5, 103.8, 125.9, 128.2, 128.3, 128.8, 128.9, 139.9, 153.9, 167.4, 169.2,
170.6, 203.9

I-114

MS(FAB):869+(M+H+). HRMS(FAB): calcd for C46H69N4O12 869.4912 found 869.4912
IR(KBr):3430, 3066, 2975, 2937, 2879, 2788, 1801, 1748, 1716, 1647, 1559, 1541, 1456,
1396, 1380, 1321, 1286, 1235, 1162, 1109, 1082, 1047, 1006, 993, 953, 895, 832, 773,
757, 693, 627, 573, 477, 413(cm-1)
13C-NMR(CD3OD):δ(ppm)10.8, 13.0, 14.7, 15.7, 16.1, 16.6, 19.0, 20.9, 21.3, 23.2, 27.7,
31.5, 32.0, 34.2, 36.4, 38.9, 40.3, 50.5, 60.4, 66.4, 69.8, 71.1, 77.2, 79.5, 79.9, 84.1, 86.7,
104.5, 127.5, 128.6, 129.2, 131.7, 132.7, 135.9, 138.5, 139.1, 151.6, 155.8, 168.4, 171.3,
175.5, 206.0

I-115

MS(FAB):871+(M+H+).HRMS(FAB):calcd for C45H67N4O13 871.4704 found 871.4706
IR(KBr):3437, 2974, 2937, 2878, 2784, 1809, 1751, 1717, 1677, 1597, 1570, 1527, 1502,
1457, 1378, 1318, 1282, 1262, 1234, 1167, 1141, 1109, 1082, 1047, 1005, 993, 953, 930,
897, 824, 792, 774, 754, 730, 693, 630, 575, 534, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.2, 15.5, 16.1, 18.8, 19.8, 21.2, 22.3, 26.3,
28.2, 33.2, 37.9, 38.1, 40.2, 47.5, 49.7, 51.0, 65.9, 67.1, 69.5, 70.3, 76.0, 78.4, 78.5, 82.5,
84.7, 103.6, 109.6, 119.9, 121.5, 126.9, 129.5, 135.9, 140.3, 149.1, 154.0, 154.4, 166.2,
169.0, 172.6, 204.1

I-116

MS(FAB):861+(M+H+).HRMS(FAB):calcd for C45H73N4O12 861.5225 found 861.5217
IR(KBr):3444, 3060, 2974, 2938, 2878, 2784, 1811, 1752, 1717, 1668, 1540, 1496, 1456,
1414, 1381, 1367, 1323, 1304, 1282, 1257, 1219, 1166, 1109, 1083, 1048, 1005, 993, 942,
895, 834, 801, 773, 749, 700, 618, 569, 511, 404(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.3, 15.7, 16.2, 17.0, 18.9, 20.0, 21.2, 22.5, 26.0,
28.2, 30.5, 32.9, 33.7, 38.3, 38.4, 40.2, 44.2, 44.3, 48.2, 49.6, 51.2, 65.9, 69.5, 70.4, 73.3,
76.2, 78.4, 79.6, 82.7, 84.4, 103.8, 125.7, 128.3, 128.4, 141.7, 154.3, 163.7, 168.9, 174.2,
203.9

I-117

MS(FAB):871+(M+H+).HRMS(FAB):calcd for C44H67N6O12 871.4817 found 871.4827
IR(KBr):3436, 2974, 2937, 2878, 2784, 1811, 1751, 1716, 1675, 1540, 1498, 1455, 1369,
1322, 1283, 1256, 1233, 1218, 1166, 1140, 1109, 1082, 1047, 1005, 993, 955, 929, 893,
866, 833, 773, 664, 631, 514, 472, 453, 435, 408(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.3, 15.4, 15.9, 18.9, 19.9, 21.2, 22.3, 26.3, 28.2,
33.1, 34.6, 37.9, 40.2, 47.5, 49.8, 51.1, 52.5, 65.9, 69.6, 70.3, 76.2, 77.8, 78.2, 78.4, 82.5,
84.6, 103.7, 128.4, 129.2, 131.8, 141.9, 142.6, 143.2, 144.2, 144.8, 153.9, 166.7, 169.2,
171.5, 204.1

I-118

MS(FAB):871+(M+H+).HRMS(FAB):calcd for C45H67N4O13 871.4704 found 871.4709
IR(KBr):3441, 3068, 2974, 2938, 2879, 2784, 1811, 1751, 1716, 1681, 1619, 1590, 1575,
1525, 1457, 1408, 1380, 1317, 1265, 1234, 1201, 1168, 1143, 1108, 1083, 1047, 1005,
992, 952, 931, 897, 834, 800, 774, 742, 693, 616, 573, 512, 454(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.3, 15.3, 15.6, 15.7, 18.8, 19.8, 21.2, 22.2, 26.2,
28.2, 33.1, 37.9, 38.6, 40.2, 47.7, 49.7, 51.0, 65.9, 67.0, 69.5, 70.3, 75.9, 78.3, 78.5, 82.4,
84.7, 103.8, 105.3, 120.2, 121.6, 129.4, 131.2, 149.1, 150.5, 153.9, 154.3, 166.3, 169.3,
172.6, 203.9

I-119

MS(FAB):886+(M+H+).HRMS(FAB):calcd for C45H68N5O13 886.4814 found 886.4821
IR(KBr):3445, 2974, 2937, 2878, 2784, 1808, 1752, 1717, 1654, 1609, 1575, 1493, 1457,
1404, 1359, 1323, 1299, 1261, 1222, 1164, 1107, 1083, 1047, 1005, 992, 951, 895, 862,
830, 757, 728, 691, 621, 530, 512, 452, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 13.0, 14.2, 15.4, 15.6, 16.0, 16.4, 16.5, 18.7, 18.8,
19.9, 21.2, 22.3, 22.4, 25.8, 26.0, 28.2, 32.9, 34.3, 37.3, 38.1, 40.2, 47.7, 48.0, 48.8, 49.4,
49.5, 51.1, 65.9, 66.9, 69.5, 70.4, 73.4, 73.6, 76.0, 78.4, 79.1, 82.4, 82.6, 84.5, 84.7, 103.8,
109.2, 109.5, 121.1, 121.5, 128.2, 129.0, 130.2, 130.5, 143.4, 144.0, 145.1, 145.2, 154.2,
154.3, 154.4, 154.6, 164.1, 164.9, 169.1, 171.9, 172.0, 203.9, 204.0

I-120

MS(FAB):885+(M+H+).HRMS(FAB):calcd for C45H69N6O12 885.4973 found 885.4971
IR(KBr):3430, 2975, 2937, 2879, 2784, 1806, 1749, 1716, 1673, 1600, 1575, 1533, 1500,
1457, 1407, 1375, 1322, 1284, 1234, 1166, 1141, 1110, 1081, 1047, 1006, 993, 950, 835,
811, 775, 755, 711, 694, 628, 572, 555, 530, 460, 435(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 12.7, 14.3, 15.2, 15.4, 15.7, 18.8, 19.9, 21.1, 22.1, 26.2,
28.3, 30.8, 32.9, 36.6, 37.8, 40.2, 45.2, 47.7, 49.7, 51.0, 65.8, 69.5, 70.3, 75.8, 78.1, 78.4,
78.6, 82.4, 84.8, 103.7, 123.4, 130.4, 132.0, 138.0, 139.0, 146.5, 147.5, 153.9, 166.5,
169.5, 172.6, 203.7

I-121

MS(FAB):861+(M+H+).HRMS(FAB):calcd for C42H65N6O13 861.4610 found 861.4606
IR(KBr):3434, 3089, 2975, 2938, 2880, 2786, 1808, 1750, 1716, 1671, 1621, 1598, 1521,
1456, 1420, 1381, 1316, 1282, 1257, 1219, 1166, 1141, 1109, 1082, 1047, 1004, 993, 952,
930, 900, 860, 834, 789, 775, 742, 682, 632, 573, 457(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 12.8, 14.2, 14.7, 15.3, 15.8, 18.6, 19.9, 21.1, 22.1, 26.0,
28.3, 32.9, 37.8, 39.0, 40.2, 47.7, 49.7, 51.0, 65.8, 67.8, 69.3, 70.1, 75.6, 77.9, 78.3, 78.4,
83.1, 85.2, 103.4, 105.9, 110.7, 124.5, 128.0, 131.6, 144.9, 154.2, 165.2, 171.7, 203.2

I-122

MS(FAB):874+(M+H+).HRMS(FAB):calcd for C44H68N5O13 874.4814 found 874.4817
IR(KBr):3434, 3070, 2975, 2938, 2879, 2785, 1809, 1750, 1715, 1671, 1592, 1539, 1456,
1409, 1380, 1322, 1283, 1256, 1233, 1166, 1141, 1108, 1082, 1047, 1005, 993, 952, 930,
900, 835, 783, 736, 682, 630, 574, 458(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 12.9, 14.3, 14.7, 15.4, 15.8, 18.7, 20.0, 21.2, 22.2, 26.1,
28.3, 32.9, 37.9, 39.3, 40.2, 47.8, 49.7, 51.0, 65.9, 67.4, 69.5, 70.3, 75.7, 78.1, 78.5, 78.6,
83.5, 85.3, 103.3, 103.7, 103.8, 110.9, 121.9, 145.4, 150.8, 154.6, 165.4, 169.4, 171.6,
203.7

I-123

MS(FAB):889+(M+H+). HRMS(FAB):calcd for C45H66F1N4O13 889.4610 found
889.4621
IR(KBr):3436, 3072, 2974, 2938, 2879, 2785, 1810, 1751, 1717, 1678, 1631, 1599, 1571,
1526, 1474, 1457, 1400, 1378, 1317, 1283, 1258, 1236, 1168, 1142, 1109, 1082, 1048,
1005, 992, 952, 930, 899, 833, 812, 789, 753, 743, 693, 633, 559, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.5, 16.1, 18.8, 19.8, 21.2, 22.3, 26.3,
28.2, 33.1, 37.9, 38.1, 40.2, 47.5, 49.7, 51.0, 65.9, 67.5, 69.5, 70.3, 76.0, 78.3, 78.4, 78.5,
82.5, 84.7, 103.7, 108.7, 108.8, 109.5, 109.8, 119.8, 120.0, 121.6, 129.2, 129.3, 140.2,
150.0, 150.2, 150.8, 150.9, 153.4, 153.9, 166.4, 169.1, 172.7, 204.0

I-124

MS(FAB):870+(M+H+).HRMS(FAB):calcd for C45H68N5O12 870.4864 found 870.4867
IR(KBr):3436, 2973, 2937, 2878, 2784, 1811, 1751, 1716, 1674, 1577, 1528, 1490, 1456,
1379, 1361, 1322, 1283, 1257, 1233, 1167, 1142, 1109, 1082, 1047, 1005, 993, 952, 931,
900, 865, 835, 801, 771, 682, 632, 573, 533, 453, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.2, 15.3, 15.7, 16.1, 18.9, 19.9, 21.1, 22.2, 26.3,
28.0, 28.2, 30.3, 33.0, 37.9, 39.0, 40.2, 47.7, 49.7, 51.0, 65.8, 69.5, 70.3, 75.9, 78.4, 78.5,
78.6, 82.4, 84.5, 103.8, 127.4, 129.3, 129.8, 141.2, 141.7, 143.1, 143.7, 144.5, 153.8,
166.3, 169.1, 172.0, 203.9

I-125

MS(FAB):913+(M+H+). HRMS(FAB):calcd for C47H73N6O12 913.5286 found 913.5279
IR(KBr):3445, 2974, 2938, 2878, 2784, 1810, 1752, 1717, 1668, 1620, 1569, 1540, 1498,
1456, 1415, 1368, 1323, 1304, 1282, 1257, 1217, 1166, 1109, 1083, 1047, 1005, 992, 954,
895, 865, 831, 773, 755, 692, 617, 569, 510, 456, 434, 407(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.3, 15.7, 16.2, 16.3, 17.0, 18.9, 20.0, 21.2, 22.5,
26.0, 28.3, 30.2, 32.9, 33.9, 38.3, 38.4, 40.3, 44.3, 44.4, 48.2, 49.6, 51.2, 66.0, 69.5, 70.4,
73.3, 76.1, 78.4, 79.7, 82.7, 84.5, 103.9, 127.8, 129.3, 131.6, 141.9, 143.2, 144.1, 144.6,
144.8, 154.4, 163.8, 168.9, 174.4, 203.9

I-126

MS(FAB):859+(M+H+).HRMS(FAB):calcd for C43H67N6O12 859.4817 found 859.4821
IR(KBr):3433, 3089, 3056, 2974, 2938, 2879, 2784, 1809, 1751, 1716, 1673, 1599, 1583,
1531, 1501, 1455, 1409, 1365, 1322, 1285, 1257, 1234, 1197, 1167, 1142, 1109, 1082,
1047, 1005, 993, 952, 932, 897, 835, 801, 775, 755, 682, 637, 574, 554, 512, 456,
431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.3, 15.2, 15.6, 15.9, 18.8, 19.9, 21.1, 22.2, 26.2,
28.4, 30.0, 33.0, 36.3, 37.8, 40.2, 41.3, 47.6, 49.7, 51.0, 65.8, 69.4, 70.3, 75.9, 78.3, 78.4,
78.5, 82.4, 84.7, 103.7, 117.9, 127.7, 135.4, 143.9, 144.7, 147.2, 153.8, 166.5, 169.3,
172.6, 203.8

I-127

MS(FAB):884+(M+H+).HRMS(FAB):calcd for C46H70N5O12 884.5021 found 884.5015
IR(KBr):3434, 2973, 2937, 2878, 2784, 1809, 1751, 1716, 1674, 1592, 1531, 1455, 1364,
1322, 1284, 1256, 1234, 1218, 1167, 1142, 1109, 1083, 1047, 1005, 992, 952, 924, 897,
862, 835, 776, 709, 694, 620, 574, 555, 512, 455, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.3, 15.2, 15.5, 15.7, 18.8, 19.9, 21.2, 22.2, 26.2,
28.2, 31.0, 32.9, 36.9, 37.9, 40.2, 47.7, 49.7, 51.0, 65.8, 69.5, 70.3, 75.9, 78.2, 78.5, 78.6,
82.5, 84.7, 103.8, 105.9, 118.1, 121.0, 122.3, 123.4, 131.9, 146.0, 146.5, 153.9, 166.3,
169.4, 172.3, 203.8

I-128

MS(FAB):885+(M+H+).HRMS(FAB):calcd for C45H69N6O12 885.4973 found 885.4973
IR(KBr):3434, 3125, 2973, 2937, 2878, 2784, 1808, 1750, 1715, 1673, 1588, 1533, 1455,
1378, 1323, 1284, 1255, 1220, 1168, 1142, 1109, 1083, 1047, 1005, 993, 952, 921, 898,
862, 833, 789, 754, 683, 652, 619, 573, 554, 513, 456, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.3, 15.2, 15.6, 15.7, 18.8, 19.9, 21.1, 22.2, 26.2,
28.2, 31.0, 32.9, 36.7, 37.8, 40.2, 47.7, 47.8, 49.7, 51.0, 65.8, 69.5, 70.3, 75.9, 78.2, 78.5,
78.6, 82.5, 84.7, 103.8, 107.0, 120.9, 121.4, 122.4, 122.7, 126.3, 148.3, 153.9, 156.8,
166.4, 169.4, 172.4, 203.8

I-129

MS(FAB):872+(M+H+).HRMS(FAB):calcd for C44H66N5O13 872.4657 found 872.4670
IR(KBr):3440, 2975, 2938, 2879, 2784, 1809, 1750, 1718, 1679, 1613, 1570, 1526, 1482,
1458, 1382, 1308, 1284, 1259, 1234, 1167, 1141, 1110, 1082, 1047, 1004, 993, 952, 929,
897, 835, 767, 742, 722, 683, 652, 632, 573, 554, 467, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.3, 15.2, 15.5, 15.9, 18.8, 19.8, 21.2, 22.2, 26.3,
28.2, 33.1, 37.9, 38.0, 40.2, 47.5, 49.8, 51.0, 65.9, 67.0, 69.5, 70.3, 75.9, 78.3, 78.4, 78.5,
82.4, 84.7, 103.7, 113.6, 118.7, 126.1, 128.4, 142.2, 153.8, 153.9, 154.4, 159.9, 166.5,
169.1, 172.9, 203.9

I-130

MS(FAB):884+(M+H+).HRMS(FAB):calcd for C46H70N5O12 884.5021 found 884.5026
IR(KBr):3434, 3129, 3067, 2973, 2937, 2878, 2784, 1809, 1751, 1716, 1674, 1600, 1557,
1531, 1455, 1376, 1322, 1284, 1256, 1219, 1167, 1142, 1109, 1082, 1047, 1005, 991, 952,
931, 897, 830, 782, 694, 672, 617, 573, 530, 457(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.3, 15.2, 15.5, 15.7, 18.8, 19.9, 21.1, 22.2, 26.2,
28.2, 30.9, 32.9, 36.8, 37.8, 40.2, 47.7, 47.8, 49.7, 51.0, 65.8, 69.5, 70.3, 75.8, 78.2, 78.5,
78.6, 82.5, 84.7, 103.8, 106.2, 119.4, 121.7, 122.6, 143.6, 149.8, 153.9, 166.4, 169.4,
172.4, 203.8

I-131

MS(FAB):885+(M+H+).HRMS(FAB):calcd for C45H69N6O12 885.4973 found 885.4976
IR(KBr):3432, 2974, 2937, 2878, 2783, 1809, 1750, 1716, 1673, 1582, 1559, 1533, 1456,
1393, 1366, 1322, 1295, 1217, 1167, 1142, 1109, 1082, 1047, 1005, 991, 952, 937, 897,
836, 806, 774, 718, 681, 664, 619, 535, 457, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.3, 15.2, 15.5, 15.7, 18.8, 19.9, 21.2, 22.2, 26.2,
28.2, 30.9, 33.0, 36.7, 37.9, 40.2, 47.7, 47.9, 49.7, 51.1, 65.9, 69.6, 70.3, 75.9, 78.2, 78.5,
78.6, 82.4, 84.7, 103.8, 107.3, 115.5, 122.4, 122.5, 123.0, 153.9, 156.2, 158.8, 161.3,
166.4, 169.4, 172.4, 203.8

I-132

MS(FAB):885+(M+H+).HRMS(FAB):calcd for C45H69N6O12 885.4973 found 885.4967
IR(KBr):3434, 3108, 3070, 2974, 2938, 2878, 2784, 1809, 1751, 1716, 1674, 1605, 1529,
1455, 1380, 1323, 1283, 1256, 1221, 1167, 1142, 1109, 1081, 1047, 1005, 991, 961, 952,
932, 896, 861, 825, 774, 755, 704, 679, 632, 573, 533, 456, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.3, 15.3, 15.7, 15.8, 18.9, 19.9, 21.2, 22.2, 26.2,
28.2, 30.2, 33.0, 36.4, 37.9, 40.2, 47.7, 49.8, 50.1, 51.1, 65.8, 69.5, 70.3, 75.9, 78.3, 78.4,
78.5, 82.5, 84.7, 103.8, 120.0, 127.9, 136.9, 140.5, 150.1, 153.9, 166.6, 169.4, 172.6,
203.8

I-133

MS(SI):888+(M+H+). HRMS(SI):calcd for C44H66N5O12S 888.4425 found 888.4428
IR(KBr):3434, 2973, 2937, 2878, 2784, 1810, 1751, 1716, 1675, 1561, 1523, 1484, 1455,
1364, 1322, 1283, 1256, 1232, 1167, 1141, 1109, 1083, 1047, 1005, 984, 951, 896, 865,
827, 809, 768, 693, 630, 573, 555, 452, 423, 404(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.3, 15.3, 15.6, 15.7, 18.9, 19.9, 21.2, 22.2, 26.2,
28.2, 29.6, 33.1, 37.9, 38.4, 40.2, 47.6, 49.8, 51.0, 65.9, 69.6, 70.3, 75.9, 78.3, 78.4, 78.5,
82.4, 84.7, 103.7, 125.4, 125.5, 130.4, 138.2, 140.9, 143.2, 143.4, 145.3, 153.8, 166.4,
169.2, 172.6, 203.9

I-134

MS(FAB):858+(M+H+).HRMS(FAB):calcd for C44H68N5O12 858.4864 found 858.4888
IR(KBr):3436, 3095, 3051, 2974, 2938, 2878, 2784, 1811, 1751, 1716, 1675, 1594, 1569,
1510, 1455, 1427, 1379, 1363, 1321, 1284, 1256, 1233, 1167, 1141, 1109, 1082, 1047,
1005, 992, 952, 931, 894, 862, 835, 798, 774, 722, 693, 631, 575, 513, 484, 454, 430(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.7, 16.2, 18.9, 19.9, 21.1, 22.3, 26.3,
28.1, 30.3, 33.1, 36.4, 38.0, 40.2, 41.9, 47.7, 49.7, 51.1, 65.8, 69.5, 70.3, 76.0, 78.5, 78.6,
78.7, 82.4, 84.6, 99.4, 103.7, 115.4, 120.6, 128.4, 128.6, 142.5, 147.6, 153.9, 166.3, 169.2,
172.2, 203.9

I-135

MS(FAB):744+(M+H+).HRMS(FAB):calcd for C36H62N3O13 744.4283 found 744.4291
IR(KBr):3437, 2975, 2938, 2879, 2786, 1811, 1751, 1717, 1670, 1533, 1456, 1379, 1323,
1284, 1257, 1234, 1167, 1142, 1110, 1082, 1047, 1005, 992, 952, 931, 897, 834, 802, 774,
755, 693, 631, 574, 533, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.8, 14.3, 15.2, 15.8, 15.9, 18.9, 19.9, 21.2, 22.3, 26.3,
28.2, 33.3, 38.0, 40.2, 42.3, 47.7, 49.7, 51.1, 62.2, 65.9, 69.6, 70.4, 75.9, 78.4, 78.5, 78.6,
82.4, 85.1, 103.7, 154.3, 166.2, 169.3, 173.2, 203.9

I-136

MS(FAB):716+(M+H+).HRMS(FAB):calcd for C34H58N3O13 716.3970 found 716.3972
IR(KBr):3433, 2976, 2938, 2880, 2787, 1812, 1751, 1715, 1676, 1456, 1379, 1322, 1284,
1257, 1234, 1167, 1142, 1109, 1081, 1047, 1006, 992, 954, 930, 917, 893, 832, 773, 754,
681, 668, 631, 571, 531, 453(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 14.3, 15.4, 15.5, 18.7, 19.9, 21.2, 22.4, 26.3, 28.3,
33.1, 37.9, 40.1, 47.4, 49.7, 51.1, 65.7, 69.4, 70.4, 76.1, 76.8, 77.9, 78.4, 82.6, 84.7, 103.6,
153.8, 166.9, 169.1, 169.4, 204.2

I-137

MS(FAB):870+(M+H+).HRMS(FAB):calcd for C45H68N5O12 870.4864 found 870.4869
IR(CHCl3):3348, 3028, 2974, 2936, 2874, 1804, 1749, 1660, 1592, 1542, 1502, 1453,
1379, 1360, 1320, 1304, 1281, 1233, 1215, 1165, 1138, 1105, 1071, 1045, 1003, 989, 949,
922, 905(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.2, 15.3, 15.6, 18.8, 19.9, 21.1, 22.1, 26.2, 28.4,
31.0, 33.0, 36.6, 37.8, 40.2, 47.5, 47.6, 49.7, 50.9, 65.9, 69.2, 70.0, 72.8, 75.8, 78.3, 78.4,
82.2, 84.5, 103.4, 105.8, 117.8, 122.0, 123.2, 131.7, 145.8, 146.2, 153.5, 167.3, 169.0,
170.4, 203.4

I-138

MS(SI):872+(M+H+). HRMS(SI):calcd for C44H66N5O13 872.4653 found 872.4652
IR(KBr):3437, 2974, 2937, 2879, 2784, 1811, 1751, 1716, 1668, 1603, 1590, 1557, 1525,
1456, 1378, 1364, 1308, 1283, 1256, 1234, 1219, 1166, 1143, 1109, 1082, 1047, 1005,
992, 950, 896, 863, 835, 801, 755, 693, 631, 573, 556, 534, 455, 418(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.4, 15.5, 15.6, 18.9, 19.8, 21.2, 22.3, 26.2,
28.2, 33.1, 36.3, 37.9, 40.2, 40.6, 47.6, 49.9, 51.1, 65.9, 69.5, 70.3, 76.2, 78.1, 78.4, 78.5,
82.8, 84.7, 103.7, 114.4, 123.5, 130.4, 131.2, 132.9, 133.4, 150.2, 153.9, 154.7, 166.2,
169.3, 172.9, 204.0

I-139

MS(FAB):859+(M+H+).HRMS(FAB):calcd for C43H67N6O12 859.4817 found 859.4823
IR(KBr):3433, 3051, 2974, 2937, 2879, 2784, 1807, 1750, 1716, 1674, 1611, 1531, 1494,
1455, 1414, 1379, 1362, 1317, 1298, 1286, 1256, 1234, 1167, 1141, 1109, 1082, 1047,
1005, 993, 953, 931, 897, 835, 778, 683, 632, 583, 513, 456, 429(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.7, 14.3, 15.2, 15.5, 15.7, 18.7, 19.8, 21.1, 22.1, 26.2,
28.2, 29.7, 32.9, 36.5, 37.8, 40.2, 43.4, 47.7, 49.6, 51.0, 65.7, 69.5, 70.3, 75.7, 78.1, 78.4,
78.5, 82.4, 84.9, 103.7, 117.8, 118.2, 126.1, 144.5, 145.5, 153.9, 156.4, 166.5, 169.5,
172.7, 203.8

I-140

MS(FAB):860+(M+H+).HRMS(FAB):calcd for C42H66N7O12 860.4769 found 860.4775
IR(KBr):3435, 3062, 2974, 2938, 2879, 2784, 1808, 1750, 1716, 1675, 1604, 1576, 1529,
1455, 1418, 1379, 1320, 1277, 1257, 1234, 1167, 1109, 1082, 1047, 1006, 993, 952, 932,
900, 862, 835, 799, 781, 692, 629, 582, 555, 513, 454(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.3, 15.2, 15.7, 18.8, 19.8, 21.1, 22.2, 26.2, 28.2,
29.6, 33.0, 36.5, 37.8, 40.2, 46.7, 47.6, 49.7, 51.0, 65.7, 69.5, 70.3, 75.9, 78.2, 78.4, 78.5,
82.4, 84.9, 103.7, 119.0, 121.9, 125.4, 148.0, 153.9, 157.5, 166.7, 169.4, 172.7, 203.9

I-141

MS(FAB):862+(M+H+).HRMS(FAB):calcd for C41H64N7O13 862.4562 found 862.4567
IR(KBr):3437, 2974, 2938, 2879, 2784, 1810, 1751, 1716, 1680, 1591, 1524, 1456, 1379,
1323, 1283, 1255, 1234, 1167, 1141, 1109, 1083, 1047, 1006, 993, 952, 929, 900, 835,
804, 775, 693, 630, 574, 508, 454, 429(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.6, 16.3, 18.9, 19.9, 21.1, 22.3, 26.4,
28.1, 33.2, 37.3, 38.0, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 76.1, 78.4, 78.5, 78.6, 79.7,
82.5, 84.6, 103.7, 120.6, 129.2, 135.0, 139.9, 151.2, 154.0, 166.5, 169.1, 172.6, 204.0

I-142

MS(FAB):886+(M+H+). HRMS(FAB):calcd for C45H68N5O13 886.4814 found 888.4813
IR(KBr):3431, 2974, 2937, 2878, 2784, 1811, 1752, 1716, 1677, 1609, 1574, 1518, 1495,
1457, 1379, 1359, 1299, 1261, 1223, 1164, 1107, 1084, 1047, 1005, 992, 953, 932, 901,
862, 830, 816, 801, 757, 729, 693, 631, 574, 513, 453, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 10.3, 12.9, 13.0, 14.3, 15.4, 15.7, 16.1, 16.5, 17.5, 17.6,
19.0, 19.9, 20.0, 21.2, 22.8, 26.4, 28.2, 33.1, 38.0, 38.1, 40.2, 44.0, 44.2, 47.7, 50.1, 51.1,
65.9, 69.5, 70.3, 71.5, 71.6, 76.0, 76.1, 78.4, 78.5, 78.6, 78.7, 78.9, 82.5, 84.5, 84.6, 103.8,
110.2, 110.3, 121.2, 121.3, 130.4, 135.6, 135.7, 143.4, 144.0, 145.1, 154.0, 154.4, 167.1,
167.2, 169.1, 169.2, 172.2, 203.8

I-143

MS(FAB):860+(M+H+).HRMS(FAB):calcd for C42H66N7O12 860.4769 found 860.4770
IR(KBr):3435, 2974, 2938, 2879, 2784, 1811, 1751, 1716, 1676, 1590, 1527, 1455, 1379,
1323, 1284, 1257, 1217, 1167, 1142, 1109, 1082, 1047, 1005, 992, 952, 931, 900, 862,
835, 804, 777, 755, 692, 631, 583, 555, 534, 456, 430(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.7, 15.9, 18.9, 19.9, 21.1, 22.3, 26.3,
28.2, 29.4, 33.1, 36.5, 37.9, 40.2, 44.6, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 76.0, 78.3, 78.4,
78.5, 82.5, 84.7, 103.7, 119.6, 128.4, 136.9, 145.9, 150.0, 153.8, 166.5, 169.2, 172.3,
203.9

I-144

MS(FAB):860+(M+H+).HRMS(FAB):calcd for C42H66N7O12 860.4769 found 860.4773
IR(KBr):3436, 2974, 2938, 2879, 2784, 1810, 1751, 1716, 1676, 1603, 1560, 1527, 1455,
1380, 1323, 1283, 1257, 1233, 1167, 1142, 1109, 1082, 1047, 1005, 992, 952, 931, 897,
862, 835, 805, 781, 755, 682, 631, 573, 555, 532, 456(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.7, 15.8, 18.9, 19.9, 21.1, 22.2, 26.3,
28.2, 29.7, 33.1, 36.4, 37.9, 40.2, 47.6, 49.8, 51.0, 55.0, 65.8, 69.5, 70.3, 76.0, 78.3, 78.5,
82.4, 84.7, 103.8, 121.7, 127.0, 136.4, 151.4, 153.8, 155.8, 166.6, 169.3, 172.5, 203.9

I-145

MS(FAB):886+(M+H+). HRMS(FAB):calcd for C45H68N5O13 886.4814 found 888.4816
IR(KBr):3441, 2975, 2937, 2878, 2784, 1810, 1751, 1716, 1681, 1607, 1572, 1526, 1492,
1472, 1456, 1379, 1359, 1322, 1296, 1257, 1233, 1164, 1108, 1084, 1047, 1005, 992, 953,
931, 894, 863, 830, 801, 759, 728, 682, 632, 573, 555, 512, 433(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.5, 16.1, 16.4, 17.7, 17.9, 18.8, 18.9,
19.8, 19.9, 21.2, 22.3, 26.3, 26.4, 28.2, 33.1, 33.2, 37.9, 40.2, 43.8, 43.9, 47.6, 49.7, 51.0,
65.8, 69.5, 70.3, 73.9, 74.7, 76.0, 76.1, 78.4, 78.5, 78.6, 82.4, 82.5, 84.6, 84.7, 103.7,
112.3, 112.5, 121.6, 121.8, 130.1, 130.4, 136.0, 136.1, 143.4, 143.6, 144.2, 145.0, 145.1,
153.6, 153.8, 154.0, 166.2, 166.8, 169.0, 169.1, 172.6, 203.9, 204.0

I-146

MS(FAB):860+(M+H+).HRMS(FAB):calcd for C43H66N5O13 860.4657 found 860.4660
IR(KBr):3433, 2974, 2938, 2879, 2786, 1809, 1751, 1716, 1672, 1632, 1591, 1513, 1455,
1379, 1311, 1283, 1254, 1236, 1166, 1141, 1108, 1083, 1047, 1005, 992, 951, 899, 862,
835, 785, 738, 683, 631, 575, 555, 454(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 12.8, 14.3, 14.9, 15.3, 15.8, 18.7, 19.9, 21.2, 22.2, 26.1,
28.2, 32.9, 37.9, 39.2, 40.2, 47.8, 49.8, 51.0, 65.8, 67.5, 69.5, 70.4, 75.7, 78.1, 78.5, 78.6,
83.3, 85.3, 103.8, 103.9, 111.7, 111.8, 122.4, 140.3, 146.3, 154.6, 165.6, 169.5, 171.9,
203.7
I-147

MS(FAB):874+(M+H+).HRMS(FAB):calcd for C44H68N5O13 874.4814 found 874.4808
IR(KBr):3439, 3090, 2974, 2938, 2879, 2784, 1808, 1751, 1715, 1676, 1615, 1591, 1527,
1503, 1456, 1423, 1378, 1348, 1281, 1258, 1235, 1166, 1109, 1081, 1047, 1005, 993, 952,
931, 916, 899, 863, 835, 781, 737, 707, 684, 630, 573, 555, 512, 454(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.0, 14.3, 15.2, 15.6, 16.4, 18.9, 19.8, 21.2, 22.3, 26.4,
28.2, 31.1, 33.3, 38.0, 38.6, 40.2, 47.6, 49.6, 51.0, 65.8, 67.4, 69.5, 70.3, 76.1, 78.4, 78.6,
82.5, 84.7, 102.6, 103.7, 104.7, 123.7, 134.0, 136.3, 142.1, 150.6, 154.0, 166.3, 169.0,
172.4, 204.1

I-148

MS(FAB):874+(M+H+).HRMS(FAB):calcd for C44H68N5O13 874.4814 found 874.4813
IR(KBr):3437, 2974, 2938, 2879, 2784, 1809, 1751, 1716, 1677, 1620, 1589, 1528, 1503,
1456, 1417, 1375, 1324, 1286, 1262, 1234, 1169, 1141, 1109, 1084, 1047, 1005, 992, 951,
931, 900, 784, 732, 682, 642, 580, 554, 510(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.8, 14.3, 15.2, 15.6, 15.7, 18.8, 19.8, 21.2, 22.2, 26.2,
28.2, 33.0, 34.0, 37.9, 38.5, 40.2, 47.6, 49.7, 51.0, 65.8, 66.7, 69.5, 70.3, 75.9, 78.3, 78.5,
82.4, 84.7, 103.7, 104.5, 113.0, 122.4, 124.4, 143.7, 145.9, 146.7, 153.9, 166.3, 169.4,
172.4, 203.9

I- 149

MS(FAB):920+(M+H+). HRMS(FAB):calcd for C44H66N5O14S1 920.4327 found 920.4323
IR(KBr):3434, 2974, 2937, 2879, 2784, 1809, 1751, 1716, 1681, 1522, 1484, 1456, 1378,
1319, 1256, 1233, 1199, 1167, 1144, 1129, 1109, 1082, 1047, 1005, 992, 952, 895, 867,
835, 774, 724, 682, 668, 647, 554, 526, 450, 421(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 14.3, 15.2, 15.6, 15.7, 18.8, 19.8, 21.2, 22.3, 26.3,
28.2, 33.1, 33.3, 37.9, 40.2, 47.6, 49.7, 51.0, 54.9, 65.8, 69.5, 70.3, 75.9, 78.0, 78.4, 78.5,
82.3, 84.7, 103.7, 129.0, 132.7, 136.0, 136.5, 139.5, 143.1, 145.7, 146.0, 153.8, 166.5,
169.2, 172.1, 204.0

I-150

MS(FAB):904+(M+H+). HRMS(FAB):calcd for C44H66N5O13S1 904.4378 found 904.4380
IR(KBr):3432, 2974, 2937, 2879, 2784, 1808, 1750, 1716, 1676, 1524, 1456, 1378, 1322,
1284, 1256, 1234, 1167, 1141, 1109, 1082, 1047, 1005, 993, 974, 952, 895, 847, 834, 773,
682, 632, 574, 552, 455, 431, 405(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 14.3, 15.3, 15.7, 15.9, 16.0, 18.8, 19.9, 20.0, 21.2,
22.3, 22.4, 26.3, 28.2, 32.9, 33.1, 38.0, 40.2, 47.6, 49.7, 51.1, 52.8, 65.8, 69.5, 70.3, 75.9,
76.1, 78.2, 78.3, 78.4, 78.5, 82.4, 82.5, 84.6, 103.7, 127.3, 127.4, 129.9, 130.0, 131.6,
131.7, 138.9, 141.8, 141.9, 142.7, 142.8, 144.4, 144.5, 146.0, 153.8, 153.9, 166.3, 166.4,
169.1, 169.2, 172.2, 204.0

I-151

MS(FAB):873+(M+H+).HRMS(FAB):calcd for C43H65N6O13 873.4610 found 873.4613
IR(KBr):3437, 2975, 2938, 2880, 2786, 1810, 1750, 1716, 1679, 1600, 1573, 1525, 1452,
1375, 1338, 1282, 1256, 1231, 1168, 1141, 1111, 1082, 1047, 1005, 992, 952, 932, 895,
842, 827, 774, 754, 697, 558, 462, 434(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.6, 16.0, 18.8, 19.8, 21.1, 22.3, 26.2,
28.4, 33.1, 37.9, 38.2, 40.2, 47.6, 49.8, 51.0, 65.8, 66.0, 69.4, 70.3, 76.0, 78.4, 78.5, 82.5,
84.6, 103.6, 115.9, 130.3, 144.3, 144.9, 147.9, 148.9, 153.8, 160.6, 166.2, 169.1, 172.4,
204.0

I-152

MS(FAB):898+(M+H+).HRMS(FAB):calcd for C47H72N5O12 898.5177 found 898.5170
IR(KBr):3436, 2973, 2938, 2878, 2784, 1809, 1750, 1716, 1673, 1593, 1523, 1455, 1374,
1322, 1284, 1256, 1223, 1167, 1142, 1109, 1082, 1047, 1005, 992, 951, 932, 902, 862,
834, 783, 755, 709, 692, 619, 573, 555, 532, 456, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 12.8, 14.2, 15.3, 15.7, 15.8, 18.8, 19.9, 21.1, 22.2, 23.8,
26.2, 28.2, 28.3, 33.0, 33.7, 37.9, 39.2, 40.2, 47.7, 49.8, 51.0, 65.8, 69.5, 70.3, 75.9, 78.3,
78.5, 82.5, 84.6, 103.6, 103.8, 118.2, 119.4, 123.4, 131.7, 132.0, 134.5, 145.8, 146.3,
153.8, 166.3, 169.3, 172.2, 203.9

I-153

MS(FAB):942+(M+H+).HRMS(FAB):calcd for C49H76N5O13 942.5440 found 942.5432
IR(KBr):3436, 2974, 2937, 2878, 2784, 1810, 1751, 1716, 1673, 1595, 1520, 1456, 1364,
1323, 1284, 1256, 1233, 1167, 1141, 1109, 1081, 1047, 1005, 992, 951, 899, 862, 834,
802, 776, 755, 717, 693, 619, 573, 533, 456, 431, 405(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 12.9, 14.3, 15.3, 15.7, 15.8, 18.9, 19.9, 21.2, 22.2, 24.1,
26.2, 28.1, 28.2, 30.4, 33.0, 37.9, 39.2, 40.2, 47.7, 49.8, 51.1, 57.5, 64.3, 65.8, 69.5, 70.3,
76.0, 78.4, 78.5, 78.6, 82.5, 84.6, 103.8, 105.0, 121.0, 123.2, 125.1, 132.8, 134.4, 135.4,
146.5, 149.2, 153.8, 166.2, 169.3, 172.2, 203.9

I-154

MS(SI):871+(M+H+). HRMS(SI):calcd for C44H67N6O12 871.4812 found 871.4811
IR(KBr):3430, 3072, 2974, 2937, 2878, 2784, 1810, 1751, 1717, 1674, 1636, 1604, 1582,
1522, 1482, 1456, 1408, 1359, 1323, 1283, 1256, 1234, 1215, 1168, 1140, 1109, 1082,
1047, 1005, 993, 952, 932, 899, 864, 826, 773, 753, 693, 555, 534, 455, 434(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.8, 14.3, 15.2, 15.7, 18.8, 19.8, 21.2, 22.3, 26.2, 28.2,
33.1, 37.9, 38.4, 40.2, 43.0, 47.7, 49.8, 51.1, 65.9, 69.6, 70.4, 75.9, 78.3, 78.5, 82.4, 84.8,
103.8, 105.0, 115.0, 131.7, 133.2, 140.9, 143.9, 145.0, 145.1, 153.9, 166.3, 169.3, 172.9,
203.9

I-155

MS(FAB):887+(M+H+).HRMS(FAB):calcd for C44H67N6O13 887.4766 found 887.4763
IR(KBr):3434, 3063, 2975, 2938, 2879, 2785, 1808, 1751, 1715, 1674, 1624, 1554, 1534,
1490, 1455, 1371, 1322, 1284, 1257, 1231, 1167, 1109, 1082, 1046, 1005, 992, 952, 931,
903, 834, 774, 716, 693, 630, 573, 528, 455, 428(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.6, 16.0, 18.9, 19.9, 21.2, 22.3, 26.3,
28.2, 29.2, 33.1, 36.0, 37.9, 40.2, 47.4, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 75.9, 78.4, 78.5,
82.4, 84.7, 103.7, 105.7, 137.3, 137.6, 143.8, 148.5, 149.6, 153.9, 161.2, 166.6, 169.3,
172.7, 203.9

I-156

MS(FAB):884+(M+H+).HRMS(FAB):calcd for C46H70N5O12 884.5021 found 884.5030
IR(KBr):3433, 3133, 2974, 2938, 2879, 2784, 1807, 1750, 1715, 1672, 1606, 1532, 1504,
1482, 1455, 1368, 1322, 1284, 1256, 1233, 1168, 1142, 1109, 1083, 1047, 1006, 993, 951,
913, 833, 801, 776, 754, 694, 628, 573, 512, 456, 432(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 12.7, 14.3, 15.2, 15.5, 15.7, 18.8, 19.8, 21.1, 22.1, 26.2,
28.2, 30.8, 32.9, 36.6, 37.8, 40.2, 45.1, 47.7, 49.7, 51.0, 65.8, 69.5, 70.3, 75.8, 78.1, 78.4,
78.5, 82.4, 84.8, 103.8, 115.0, 124.8, 126.4, 128.4, 134.5, 137.4, 142.0, 153.9, 166.5,
169.4, 172.6, 203.8

I-157

MS(FAB):836+(M+H+).HRMS(FAB):calcd for C42H66N3O14 836.4545 found 836.4541
IR(KBr):3436, 2975, 2938, 2879, 2785, 1809, 1751, 1716, 1672, 1596, 1527, 1503, 1457,
1378, 1323, 1304, 1265, 1221, 1167, 1142, 1109, 1083, 1047, 1006, 992, 952, 932, 900,
861, 835, 802, 773, 746, 693, 631, 575, 555, 517, 454(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.7, 14.3, 15.1, 15.2, 15.7, 18.7, 19.8, 21.2, 22.2, 26.1,
28.2, 33.0, 37.9, 39.1, 40.2, 47.7, 49.6, 51.0, 65.8, 68.6, 69.6, 70.4, 75.8, 78.2, 78.4, 78.5,
82.6, 85.0, 103.7, 112.3, 115.1, 119.7, 121.5, 146.4, 154.1, 165.7, 169.4, 172.6, 203.9

I-158

MS(FAB):900+(M+H+). HRMS(FAB):calcd for C46H70N5O13 900.4970 found 900.4978
IR(KBr):3436, 2974, 2938, 2878, 2785, 1811, 1751, 1716, 1672, 1566, 1530, 1497, 1457,
1373, 1323, 1285, 1255, 1235, 1166, 1108, 1082, 1047, 1005, 992, 952, 932, 890, 837,
802, 774, 755, 693, 572, 532, 438(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.6, 16.0, 18.9, 19.9, 21.1, 22.2, 26.2,
27.3, 28.2, 30.2, 33.0, 37.9, 39.1, 40.2, 47.6, 49.8, 51.1, 62.8, 65.9, 69.5, 70.3, 76.0, 78.4,
78.6, 82.4, 84.6, 103.7, 124.6, 132.2, 135.0, 137.8, 142.9, 143.5, 144.0, 153.0, 153.9,
166.3, 169.2, 172.1, 203.9

I-159

MS(FAB):906+(M+H+). HRMS(FAB):calcd for C44H65ClN5O13 906.4267 found 906.4268
IR(KBr): 3438, 2975, 2938, 2879, 2785, 1811, 1752, 1716, 1680, 1596, 1566, 1526, 1482,
1455, 1371, 1322, 1285, 1256, 1234, 1168, 1141, 1109, 1084, 1047, 1005, 992, 952, 930,
894, 835, 774, 755, 693, 651, 573, 509, 455, 437(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.0, 14.3, 15.3, 15.6, 16.7, 18.9, 19.9, 21.1, 22.4, 26.4,
28.2, 33.2, 38.0, 39.5, 40.2, 47.6, 49.7, 51.1, 65.9, 69.5, 70.3, 73.9, 76.1, 78.4, 78.7, 79.0,
82.4, 84.6, 103.7, 125.7, 127.8, 131.4, 138.3, 142.9, 144.7, 145.2, 150.8, 154.1, 166.3,
169.1, 171.9, 204.0

I-160

MS(FAB):886+(M+H+). HRMS(FAB):calcd for C45H68N5O13 886.4814 found 886.4805
IR(KBr): 3435, 2974, 2938, 2879, 2785, 1811, 1751, 1716, 1672, 1576, 1530, 1504, 1458,
1381, 1361, 1323, 1279, 1233, 1166, 1141, 1109, 1082, 1047, 1005, 992, 952, 901, 866,
833, 774, 755, 694, 555, 455, 437(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.3, 15.3, 15.7, 16.1, 18.9, 19.9, 21.1, 22.3, 26.3,
27.2, 28.2, 29.4, 33.1, 38.0, 38.9, 40.2, 47.7, 49.8, 51.1, 65.9, 69.5, 70.3, 76.1, 78.4, 78.5,
78.6, 82.5, 84.6, 103.7, 119.1, 124.7, 132.8, 133.3, 142.0, 142.1, 144.6, 149.0, 153.9,
166.3, 169.2, 172.1, 203.9

I-161

MS(FAB):862+(M+H+).HRMS(FAB):calcd for C42H64N5O14 862.4450 found 862.4441
IR(KBr):3439, 2975, 2938, 2879, 2785, 1810, 1751, 1716, 1681, 1586, 1540, 1496, 1456,
1408, 1382, 1359, 1322, 1283, 1261, 1238, 1217, 1166, 1109, 1082, 1047, 1005, 992, 951,
930, 887, 835, 799, 781, 693, 658, 632, 577, 555, 512, 455, 430(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 12.9, 14.3, 15.3, 15.6, 15.9, 18.9, 19.8, 21.1, 22.3, 26.3,
28.2, 33.1, 37.9, 38.2, 40.2, 47.6, 49.8, 51.0, 65.8, 69.1, 69.5, 70.3, 76.1, 78.4, 78.5, 82.5,
84.6, 103.7, 117.9, 124.1, 133.2, 147.2, 153.8, 157.0, 166.0, 166.4, 169.1, 172.4, 204.0

I-162

MS(FAB):874+(M+H+).HRMS(FAB):calcd for C45H68N3O14 874.4701 found 874.4709
IR(KBr):3442, 2974, 2938, 2879, 2784, 1812, 1752, 1716, 1680, 1611, 1589, 1524, 1491,
1456, 1379, 1363, 1322, 1278, 1260, 1233, 1195, 1167, 1141, 1108, 1083, 1047, 1005,
992, 952, 937, 899, 851, 834, 801, 773, 755, 732, 694, 628, 573, 555, 534, 458, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.0, 14.3, 15.2, 15.5, 16.2, 18.8, 19.8, 21.1, 22.3,
26.3, 28.2, 33.2, 37.9, 38.6, 40.2, 47.5, 49.8, 51.1, 65.9, 67.3, 69.5, 70.3, 76.1, 78.4, 78.5,
82.4, 84.6, 102.9, 103.7, 107.1, 112.8, 123.1, 131.0, 143.8, 153.9, 155.4, 166.5, 169.1,
172.6, 204.1

I-163

MS(SI):885+(M+H+). HRMS(SI):calcd for C44H65N6O13 885.4605 found 885.4598
IR(KBr):3425, 3364, 2974, 2937, 2879, 2784, 1810, 1751, 1687, 1579, 1531, 1483, 1457,
1404, 1377, 1362, 1307, 1282, 1261, 1220, 1167, 1142, 1109, 1082, 1047, 1005, 992, 950,
896, 864, 833, 819, 768, 692, 632, 558, 537, 450, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.8, 14.3, 15.2, 15.5, 16.2, 18.9, 19.9, 21.2, 22.3, 26.4,
28.2, 33.3, 37.9, 40.2, 44.2, 47.6, 49.7, 51.1, 65.8, 69.5, 70.3, 76.1, 78.2, 78.4, 78.5, 82.3,
84.7, 103.7, 117.1, 123.2, 131.0, 133.5, 134.2, 142.4, 142.8, 145.3, 153.7, 167.0, 167.4,
169.2, 173.5, 204.1

I-164

MS(FAB):861+(M+H+). HRMS(FAB):calcd for C43H65N4O14 861.4497 found 861.4506
IR(KBr): 3439, 2975, 2938, 2880, 2786, 1809, 1751, 1716, 1676, 1617, 1526, 1499, 1457,
1380, 1307, 1281, 1236, 1167, 1142, 1109, 1084, 1047, 1006, 992, 952, 931, 899, 835,
781, 740, 693, 629, 574, 533, 454(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.3, 15.5, 16.2, 18.9, 19.8, 21.2, 22.3, 26.3,
28.2, 33.2, 38.0, 38.5, 40.2, 47.5, 49.7, 51.1, 65.9, 67.6, 69.5, 70.3, 76.0, 78.4, 78.5, 82.5,
84.7, 103.6, 103.7, 107.9, 126.3, 129.7, 150.9, 151.0, 151.6, 154.0, 166.5, 169.1, 172.6,
204.1

I-165

MS(FAB):877+(M+H+). HRMS(FAB):calcd for C43H65N4O13S 877.4269 found 877.4266
IR(KBr): 3438, 3073, 2974, 2938, 2879, 2785, 1808, 1751, 1715, 1677, 1566, 1528, 1456,
1378, 1328, 1273, 1235, 1167, 1142, 1109, 1082, 1047, 1005, 992, 952, 900, 864, 835,
772, 741, 691, 630, 573, 555, 532, 456(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.3, 15.2, 15.5, 16.1, 18.8, 19.8, 21.2, 22.3, 26.3,
28.2, 33.1, 37.9, 38.3, 40.2, 47.5, 49.7, 51.0, 65.8, 67.2, 69.5, 70.3, 76.0, 78.4, 78.5, 82.5,
84.7, 103.7, 108.1, 114.0, 126.6, 135.5, 143.6, 152.3, 152.9, 154.0, 166.3, 169.1, 172.6,
204.0

I-166

MS(SI):958+(M+H+). HRMS(SI):calcd for C48H72N5O15 958.5021 found 958.5029
IR(KBr):3442, 2974, 2937, 2879, 2784, 1807, 1747, 1656, 1617, 1498, 1456, 1370, 1302,
1283, 1222, 1198, 1166, 1109, 1082, 1047, 1005, 992, 950, 875, 830, 775, 692, 659, 613,
553, 512, 454, 415(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 10.3, 12.9, 13.0, 14.3, 15.6, 15.7, 15.9, 16.0, 16.5, 18.8,
18.9, 19.9, 20.0, 20.7, 20.8, 21.2, 22.3, 22.5, 25.9, 28.3, 32.9, 38.2, 40.2, 46.7, 47.5, 47.8,
47.9, 48.0, 48.1, 49.5, 51.1, 51.2, 62.2, 62.7, 65.9, 66.2, 66.9, 69.5, 70.4, 73.1, 73.3, 75.9,
76.3, 78.3, 79.1, 82.4, 82.7, 84.6, 84.7, 103.8, 107.6, 107.9, 123.2, 130.4, 130.7, 139.3,
139.4, 142.3, 142.7, 144.6, 144.8, 144.9, 145.1, 154.4, 154.5, 159.6, 159.8, 164.9, 165.0,
168.9, 169.0, 170.6, 170.7, 172.7, 172.8, 203.9, 204.0

I-167

MS(SI):916+(M+H+). HRMS(SI):calcd for C46H70N5O14 916.4915 found 916.4911
IR(KBr):3433, 2974, 2937, 2878, 2785, 1806, 1752, 1717, 1649, 1617, 1498, 1456, 1370,
1302, 1257, 1223, 1198, 1166, 1109, 1082, 1047, 1006, 993, 950, 873, 830, 775, 755, 692,
660, 620, 553, 511, 453, 415(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 10.4, 13.0, 14.3, 15.5, 16.1, 16.5, 16.6, 18.8, 18.9, 19.9,
20.0, 21.2, 22.4, 26.0, 26.1, 28.3, 32.9, 38.2, 40.2, 47.5, 48.1, 48.2, 48.5, 49.6, 51.1, 51.2,
51.3, 51.9, 61.6, 62.0, 65.9, 66.7, 66.8, 69.5, 70.4, 73.1, 73.3, 75.9, 76.1, 78.3, 79.2, 82.6,
82.7, 84.9, 85.0, 103.8, 107.6, 107.8, 123.1, 123.2, 130.4, 130.6, 139.2, 139.3, 142.3,
142.6, 144.6, 144.7, 144.9, 145.1, 154.7, 154.9, 159.5, 159.8, 164.8, 165.0, 168.9, 169.0,
173.0, 173.8, 203.9

I-168

MS(FAB):917+(M+H+).HRMS(FAB):calcd for C44H65N6O15 917.4508 found 917.4502
IR(CHCl3):3378, 3018, 2970, 2932, 2870, 2780, 1795, 1750, 1624, 1562, 1516, 1454,
1433, 1378, 1360, 1324, 1281, 1255, 1226, 1219, 1158, 1141, 1108, 1083, 1045, 1005,
990, 949, 930, 907, 890, 860, 831, 799, 692, 663, 631, 566, 552, 540, 528, 522, 516, 512,
507, 501(cm-1)
13C-NMR(CDCl3):δ(ppm)10.4, 13.0, 14.3, 15.4, 15.9, 16.5, 18.8, 19.7, 21.0, 22.4, 26.1,
29.4, 32.9, 38.0, 40.1, 42.0, 47.7, 49.5, 51.1, 62.4, 66.4, 67.5, 68.6, 69.8, 71.8, 76.1, 78.0,
78.9, 82.3, 84.5, 102.8, 102.9, 118.5, 135.0, 135.9, 139.1, 141.4, 144.8, 145.6, 154.1,
164.6, 168.7, 172.1, 203.6

I-169

MS(FAB):887+(M+H+).HRMS(FAB):calcd for C44H67N6O13 887.4766 found 887.4783
IR(KBr):3424, 2974, 2938, 2879, 2784, 1806, 1751, 1718, 1615, 1569, 1511, 1456, 1413,
1380, 1315, 1281, 1256, 1232, 1167, 1144, 1111, 1083, 1047, 1005, 992, 952, 908, 873,
830, 776, 756, 694, 614, 570, 531, 453, 434, 412(cm-1)
13C-NMR(CDCl3):δ(ppm) 10.3, 13.0, 14.3, 15.4, 15.9, 16.7, 18.8, 19.8, 21.1, 22.4, 26.2,
28.7, 33.0, 38.0, 40.1, 43.1, 47.8, 49.5, 51.1, 63.4, 66.1, 67.5, 69.0, 70.0, 71.9, 76.1, 78.1,
79.1, 82.5, 84.6, 102.9, 103.3, 117.7, 118.9, 127.6, 134.4, 137.5, 140.9, 142.1, 154.3,
164.6, 168.7, 172.5, 203.6

I-170

MS(FAB):916+(M+H+).HRMS(FAB):calcd for C46H70N5O14 916.4919 found 916.4931
IR(KBr):3440, 2974, 2937, 2878, 2784, 1809, 1751, 1716, 1676, 1617, 1525, 1498, 1455,
1371, 1303, 1284, 1257, 1224, 1199, 1166, 1139, 1111, 1083, 1047, 1005, 992, 949, 876,
830, 802, 774, 755, 682, 660, 613, 573, 553, 474, 456, 416(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 14.2, 15.3, 15.6, 16.1, 18.8, 19.8, 21.1, 22.3, 26.3,
28.3, 33.0, 37.9, 38.7, 40.1, 47.6, 49.7, 51.0, 65.8, 67.9, 68.9, 69.4, 69.8, 70.3, 76.0, 78.4,
78.5, 78.6, 82.4, 84.6, 103.7, 107.4, 123.7, 130.3, 139.2, 142.4, 144.5, 144.8, 153.9, 159.9,
166.4, 169.2, 172.3, 203.9

I-171

MS(FAB):914+(M+H+). HRMS(FAB):calcd for C44H72N5O13 914.5127 found 914.5115
IR(KBr):3432, 2974, 2937, 2878, 2785, 1806, 1752, 1716, 1647, 1498, 1456, 1369, 1322,
1284, 1257, 1234, 1218, 1166, 1142, 1109, 1081, 1048, 1005, 993, 954, 895, 865, 831,
775, 755, 692, 665, 622, 511, 426, 409(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 10.3, 13.0, 14.3, 15.4, 15.5, 16.2, 16.5, 16.6, 18.8, 19.9,
20.0, 21.2, 22.4, 26.0, 28.3, 28.7, 30.8, 32.8, 33.1, 33.5, 38.2, 40.2, 47.4, 48.0, 48.1, 49.2,
49.5, 49.6, 50.4, 51.0, 51.1, 61.5, 62.0, 65.9, 69.5, 70.4, 73.4, 76.0, 76.1, 78.3, 79.2, 82.5,
82.7, 84.8, 103.8, 127.7, 127.8, 129.2, 129.4, 131.5, 141.8, 143.1, 143.2, 144.0, 144.1,
144.3, 144.7, 144.8, 145.0, 154.6, 154.7, 164.7, 164.9, 168.8, 168.9, 172.4, 173.2, 203.8

I-172

MS(SI):941+(M+H+). HRMS(SI):calcd for C49H77N6O12 941.5595 found 941.5596
IR(KBr):3431, 2973, 2937, 2877, 2780, 1806, 1752, 1717, 1653, 1498, 1456, 1369, 1322,
1285, 1258, 1233, 1219, 1167, 1142, 1109, 1081, 1047, 1005, 993, 955, 932, 895, 865,
831, 775, 692, 626, 529, 510, 453, 425, 408(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 10.5, 13.0, 13.1, 14.2, 15.5, 15.6, 16.1, 16.2, 16.6, 16.7,
18.8, 20.0, 21.1, 21.2, 22.4, 22.5, 26.0, 26.1, 28.2, 28.7, 30.9, 32.8, 32.9, 33.1, 33.5, 38.1,
40.2, 44.7, 45.3, 45.6, 46.1, 47.0, 47.9, 48.0, 48.1, 49.6, 49.7, 51.1, 51.2, 56.3, 58.6, 65.9,
69.5, 70.4, 73.3, 73.7, 76.0, 76.3, 78.3, 79.3, 82.4, 84.4, 84.5, 103.8, 127.8, 127.9, 129.3,
129.4, 131.5, 131.6, 141.8, 141.9, 143.1, 143.2, 144.0, 144.3, 144.6, 144.8, 144.9, 154.3,
164.8, 168.8, 169.0, 171.6, 171.7, 203.8, 203.9

I-173

MS(FAB):893+(M+H+). HRMS(FAB):calcd for C43H65N4O14S 893.4218 found 893.4221
IR(KBr):3435, 3090, 2974, 2938, 2879, 2785, 1808, 1751, 1698, 1612, 1585, 1531, 1492,
1455, 1380, 1322, 1276, 1234, 1169, 1109, 1082, 1047, 1006, 992, 951, 899, 834, 766,
723, 687, 643, 556, 531, 458, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.7, 14.2, 14.9, 15.3, 15.8, 18.7, 19.8, 21.2, 22.2, 26.1,
28.2, 32.9, 37.9, 38.9, 40.1, 47.8, 49.6, 51.0, 65.8, 68.1, 69.5, 70.3, 75.8, 78.1, 78.5, 82.8,
85.1, 103.7, 108.7, 114.6, 123.1, 124.5, 125.5, 144.3, 154.2, 165.5, 169.5, 170.8, 172.2,
203.8

I-174

MS(FAB):892+(M+H+). HRMS(FAB):calcd for C43H66N5O13S 892.4378 found 892.4374
IR(KBr):3435, 3348, 2974, 2938, 2879, 2785, 1808, 1751, 1716, 1671, 1625, 1569, 1540,
1457, 1426, 1379, 1323, 1283, 1252, 1199, 1166, 1141, 1109, 1082, 1047, 1005, 992, 952,
898, 834, 771, 734, 682, 631, 573, 531, 457, 404(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.8, 14.3, 15.2, 15.7, 15.8, 18.7, 19.8, 21.2, 22.3, 26.3,
28.2, 33.1, 37.9, 38.6, 40.2, 47.7, 49.7, 51.0, 65.8, 67.4, 69.5, 70.3, 75.9, 78.3, 78.4, 78.6,
82.5, 84.9, 103.7, 108.7, 113.5, 121.8, 132.2, 141.9, 149.3, 154.1, 166.2, 167.2, 169.3,
172.6, 203.9

I-175

MS(SI):927+(M+H+). HRMS(SI):calcd for C48H75N6O12 927.5439 found 927.5439
IR(KBr):3433, 2972, 2937, 2877, 2780, 1808, 1752, 1716, 1649, 1541, 1498, 1455, 1379,
1305, 1284, 1258, 1232, 1218, 1167, 1142, 1109, 1075, 1048, 1005, 992, 955, 931, 894,
865, 831, 776, 693, 667, 513, 407(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 10.4, 13.1, 14.3, 15.5, 15.8, 18.8, 19.8, 21.2, 22.4, 26.5,
28.2, 28.7, 30.1, 33.0, 33.4, 38.3, 40.2, 43.9, 45.3, 45.7, 45.8, 46.2, 47.5, 47.8, 49.7, 51.1,
56.6, 58.3, 65.9, 69.5, 70.3, 70.7, 70.9, 76.2, 78.5, 79.4, 82.6, 84.7, 103.8, 127.8, 127.9,
129.3, 129.6, 131.4, 131.6, 141.8, 141.9, 143.2, 143.7, 144.2, 144.4, 144.9, 145.1, 154.3,
165.9, 166.0, 168.9, 169.1, 169.2, 204.0

I-176

MS(FAB):955+(M+H+). HRMS(FAB):calcd for C50H79N6O12 955.5756 found 955.5738
IR(KBr):3439, 3126, 2973, 2938, 2878, 2826, 2779, 1805, 1752, 1716, 1654, 1592, 1570,
1551, 1504, 1456, 1366, 1321, 1284, 1258, 1218, 1166, 1142, 1109, 1083, 1047, 1005,
993, 951, 925, 896, 862, 835, 776, 709, 620, 511, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 10.5, 13.0, 14.2, 15.6, 15.7, 16.2, 16.6, 18.8, 20.0, 21.2,
22.3, 22.5, 25.9, 26.0, 28.2, 29.3, 31.3, 32.7, 32.8, 38.1, 38.2, 40.2, 44.7, 45.0, 45.5, 45.7,
45.8, 46.2, 47.3, 47.7, 48.1, 49.6, 49.7, 51.1, 56.7, 58.7, 65.9, 69.5, 70.4, 73.4, 76.0, 76.3,
78.3, 79.3, 79.4, 82.5, 82.6, 84.5, 84.6, 103.8, 106.0, 106.4, 117.9, 118.0, 121.0, 121.3,
122.1, 122.2, 123.4, 131.8, 131.9, 132.0, 146.1, 146.3, 146.5, 154.3, 154.4, 164.7, 164.8,
168.9, 169.0, 171.5, 172.1, 203.8

I-177

MS(FAB):943+(M+H+). HRMS(FAB):calcd for C48H75N6O13 943.5392 found 943.5383
IR(CHCl3):2970, 2934, 2868, 2826, 1797, 1751, 1713, 1648, 1609, 1575, 1493, 1456,
1407, 1380, 1359, 1323, 1297, 1258, 1232, 1219, 1161, 1141, 1105, 1083, 1045, 1004,
991, 949, 928, 724, 665, 526, 519, 515, 507(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 10.5, 13.0, 14.2, 15.5, 15.7, 16.2, 16.3, 16.6, 18.8, 18.8,
20.0, 21.2, 22.3, 22.5, 25.9, 26.0, 28.2, 32.8, 32.9, 38.2, 40.2, 44.7, 45.1, 47.0, 47.4, 47.6,
48.2, 49.5, 49.7, 51.2, 56.0, 57.6, 65.9, 66.1, 67.3, 69.5, 70.4, 73.4, 75.9, 76.2, 78.4, 79.3,
82.3, 82.6, 84.4, 84.7, 103.8, 109.0, 109.6, 121.0, 121.6, 130.3, 130.7, 135.4, 143.2, 143.4,
144.0, 145.1, 145.2, 154.0, 154.3, 154.4, 154.5, 164.5, 164.7, 169.0, 169.1, 172.6, 172.9,
203.8, 203.9

I-178

MS(FAB):931+(M+H+). HRMS(FAB):calcd for C47H75N6O13 931.5392 found 931.5401
IR(CHCl3):2970, 2934, 2868, 2824, 2776, 1796, 1751, 1712, 1647, 1590, 1505, 1455,
1423, 1381, 1369, 1309, 1283, 1254, 1230, 1221, 1166, 1142, 1084, 1046, 1006, 990, 949,
894, 788, 721, 666, 557, 550, 544, 530, 526, 521, 515, 507(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 10.4, 12.9, 13.0, 14.2, 15.5, 15.6, 16.0, 16.6, 16.7, 18.7,
19.9, 21.2, 22.3, 22.4, 26.0, 28.2, 32.8, 38.1, 45.0, 45.1, 45.2, 46.5, 46.9, 47.4, 48.0, 48.1,
49.4, 49.5, 51.1, 56.2, 58.0, 65.7, 67.1, 68.2, 69.4, 70.3, 73.3, 73.5, 75.9, 76.0, 78.2, 78.3,
79.0, 79.1, 82.4, 84.4, 84.5, 103.6, 104.0, 104.1, 110.7, 111.0, 122.1, 122.3, 126.1, 140.1,
140.5, 142.5, 146.0, 164.6, 164.7, 168.7, 168.8, 171.8, 172.0, 203.4, 203.5

I-179

MS(FAB):967+(M+H+). HRMS(FAB):calcd for C51H79N6O12 967.5756 found 967.5755
IR(KBr):3432, 2971, 2935, 2877, 2786, 1808, 1752, 1716, 1652, 1498, 1455, 1369, 1305,
1284, 1257, 1232, 1218, 1166, 1141, 1110, 1081, 1047, 1004, 993, 954, 931, 896, 865,
831, 775, 692, 667, 624, 568, 511, 451, 428, 408(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 10.5, 12.9, 13.0, 14.2, 15.4, 15.6, 16.0, 16.1, 16.5, 16.7,
18.8, 19.9, 21.1, 21.2, 22.3, 22.4, 23.4, 25.9, 26.0, 28.1, 28.7, 30.9, 32.7, 32.8, 33.1, 33.4,
38.1, 40.1, 45.2, 46.9, 47.9, 48.0, 48.1, 49.5, 49.6, 53.0, 53.9, 54.2, 55.1, 65.7, 69.4, 70.2,
73.2, 73.5, 75.9, 76.1, 78.2, 79.1, 82.2, 82.3, 84.3, 84.4, 103.6, 127.5, 127.6, 129.0, 129.1,
131.3, 131.4, 141.5, 141.6, 142.8, 142.9, 143.7, 143.8, 144.0, 144.3, 144.5, 144.6, 153.9,
154.0, 164.4, 164.5, 168.5, 168.6, 171.3, 171.4, 203.4, 203.5

I-180

MS(FAB):983+(M+H+). HRMS(FAB):calcd for C51H79N6O13 983.5705 found 983.5707
IR(KBr):3444, 2971, 2937, 2877, 1808, 1752, 1716, 1652, 1498, 1455, 1369, 1322, 1301,
1284, 1257, 1218, 1166, 1141, 1114, 1081, 1047, 1006, 993, 954, 929, 894, 867, 831, 775,
692, 665, 626, 511, 408(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 10.5, 13.0, 14.2, 15.5, 15.6, 16.0, 16.1, 16.6, 16.7, 18.8,
18.9, 19.9, 21.1, 21.2, 22.3, 22.4, 25.9, 26.0, 28.2, 28.5, 30.9, 32.8, 32.9, 33.1, 33.5, 38.1,
40.2, 44.2, 45.2, 46.8, 47.9, 48.0, 48.1, 49.5, 49.6, 51.1, 51.2, 53.8, 54.0, 55.9, 58.0, 65.9,
66.9, 69.4, 70.3, 73.4, 73.9, 76.0, 76.2, 78.3, 79.2, 82.4, 82.5, 84.4, 103.7, 127.8, 127.9,
129.3, 129.4, 131.4, 131.6, 141.8, 141.9, 143.1, 143.2, 144.0, 144.1, 144.3, 144.5, 144.8,
145.0, 154.3, 154.4, 164.7, 164.9, 168.9, 171.4, 171.5, 203.8

I-181

MS(FAB):873+(M+H+). HRMS(FAB):calcd for C44H69N6O12 873.4973 found 873.4982
IR(KBr):3430, 3089, 3054, 2975, 2937, 2879, 2784, 1806, 1751, 1716, 1652, 1598, 1583,
1500, 1455, 1409, 1369, 1322, 1286, 1259, 1232, 1220, 1197, 1168, 1108, 1083, 1047,
1006, 993, 952, 931, 896, 863, 835, 802, 775, 746, 690, 636, 511, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 10.3, 12.9, 14.2, 15.4, 15.7, 15.9, 16.4, 16.6, 18.7, 18.8,
19.9, 21.1, 21.2, 22.3, 22.4, 25.8, 26.0, 27.3, 28.7, 29.3, 32.9, 33.8, 35.4, 38.0, 40.1, 41.3,
41.5, 45.3, 47.3, 47.8, 49.2, 49.5, 51.0, 65.8, 69.1, 70.1, 73.2, 73.5, 75.9, 76.0, 78.9, 79.0,
82.2, 82.4, 84.4, 84.5, 103.4, 117.7, 117.9, 123.5, 124.7, 127.4, 127.6, 135.2, 143.6, 143.8,
144.5, 146.8, 154.0, 154.3, 164.2, 164.8, 168.6, 168.7, 170.9, 171.5, 203.3, 203.4

I-182

MS(FAB):886+(M+H+). HRMS(FAB):calcd for C45H68N5O13 886.4814 found 886.4805
IR(KBr):3440, 2975, 2937, 2879, 2784, 1806, 1751, 1716, 1652, 1614, 1569, 1482, 1457,
1382, 1307, 1284, 1259, 1234, 1168, 1110, 1083, 1047, 1004, 993, 952, 931, 896, 835,
767, 740, 721, 690, 622, 512, 449(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 14.2, 15.4, 15.6, 16.1, 16.3, 16.5, 18.7, 18.8, 19.9,
21.2, 22.4, 22.5, 25.8, 26.0, 28.2, 32.9, 33.0, 34.3, 37.3, 38.1, 40.2, 47.6, 48.0, 48.8, 49.4,
49.5, 51.1, 65.4, 65.9, 66.7, 69.5, 70.4, 73.3, 73.6, 76.0, 78.4, 79.1, 82.3, 82.6, 84.5, 84.7,
103.8, 113.0, 113.3, 118.4, 118.9, 126.0, 128.3, 128.4, 128.6, 142.2, 142.3, 153.7, 153.8,
154.2, 154.3, 154.4, 154.6, 159.8, 164.1, 164.9, 169.1, 172.0, 172.1, 203.9

I-183

MS(FAB):996+(M+H+). HRMS(FAB):calcd for C52H82N7O12 996.6021 found 996.6029
IR(KBr):3444, 2973, 2937, 2877, 2840, 2794, 2690, 1808, 1752, 1716, 1652, 1498, 1455,
1369, 1299, 1284, 1257, 1232, 1218, 1166, 1141, 1110, 1083, 1047, 1008, 993, 954, 929,
894, 865, 831, 794, 775, 692, 665, 624, 509, 447, 431, 406(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 10.4, 13.0, 14.2, 15.5, 15.6, 16.0, 16.6, 16.8, 18.8, 19.9,
21.1, 21.2, 22.3, 22.4, 26.0, 26.1, 28.3, 28.5, 30.9, 32.9, 33.1, 33.5, 38.1, 40.2, 44.3, 45.5,
45.8, 46.9, 47.9, 48.0, 49.5, 49.6, 50.2, 51.1, 53.0, 53.3, 54.8, 54.9, 55.3, 57.5, 65.8, 69.4,
70.4, 73.5, 73.8, 76.0, 76.2, 78.3, 79.2, 82.4, 82.5, 84.5, 84.6, 103.7, 127.7, 127.8, 129.2,
129.3, 131.6, 131.7, 141.8, 143.1, 143.2, 144.0, 144.2, 144.3, 144.7, 144.8, 144.9, 164.8,
164.9, 168.9, 169.0, 171.5, 171.7, 203.8, 203.9

I-184

MS(FAB):955+(M+H+). HRMS(FAB):calcd for C50H79N6O12 955.5757 found 955.5743
IR(KBr):3444, 2973, 2937, 2877, 2819, 2782, 1808, 1752, 1716, 1687, 1652, 1569, 1498,
1457, 1367, 1321, 1284, 1259, 1218, 1166, 1141, 1110, 1081, 1047, 1006, 993, 954, 931,
894, 867, 831, 775, 755, 692, 665, 628, 566, 511, 453, 430, 408(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 10.4, 13.0, 14.2, 15.5, 15.6, 16.0, 16.7, 16.9, 18.8, 18.9,
19.9, 21.2, 21.3, 22.3, 22.4, 25.0, 26.0, 27.7, 28.2, 28.4, 28.6, 32.9, 33.1, 33.5, 38.1, 40.2,
44.8, 45.2, 45.9, 46.4, 47.6, 48.0, 48.1, 49.5, 49.6, 51.1, 56.4, 56.8, 65.9, 69.5, 70.3, 73.7,
73.8, 76.0, 76.2, 78.3, 79.3, 82.5, 84.5, 103.8, 127.7, 127.8, 129.3, 129.4, 131.5, 131.6,
141.8, 141.9, 143.1, 143.2, 144.0, 144.3, 144.6, 144.8, 144.9, 154.3, 164.7, 164.8, 168.8,
169.0, 171.5, 171.6, 203.8

I-185

MS(FAB):990+(M+H+). HRMS(FAB):calcd for C52H76N7O12 990.5552 found 990.5547
IR(KBr):3417, 2973, 2937, 2877, 2784, 1806, 1752, 1716, 1652, 1604, 1571, 1498, 1455,
1369, 1322, 1286, 1257, 1234, 1218, 1166, 1110, 1081, 1047, 1004, 993, 954, 931, 894,
865, 831, 773, 736, 682, 626, 511, 455, 408(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 10.4, 13.0, 14.2, 14.3, 15.5, 15.6, 16.1, 16.2, 16.7, 16.8,
18.8, 19.9, 20.0, 21.2, 22.4, 26.0, 28.2, 28.6, 30.9, 32.8, 33.1, 33.5, 38.2, 40.2, 40.6, 41.7,
47.1, 47.2, 47.4, 48.1, 48.2, 48.7, 49.5, 49.6, 51.1, 65.9, 69.5, 70.4, 73.5, 74.0, 75.9, 76.0,
78.3, 79.3, 79.4, 82.5, 82.6, 84.7, 84.9, 103.8, 107.6, 108.6, 112.3, 112.6, 127.7, 127.8,
129.2, 129.4, 131.5, 136.9, 137.1, 141.8, 141.9, 143.1, 143.2, 143.9, 144.0, 144.3, 144.6,
144.7, 144.9, 147.7, 147.8, 154.6, 154.9, 158.5, 158.6, 164.3, 164.6, 168.8, 168.9, 172.2,
172.5, 203.8, 203.9

I-186

MS(FAB):954+(M+H+). HRMS(FAB):calcd for C49H76N7O12 954.5552 found 954.5544
IR(KBr):3434, 2973, 2937, 2877, 2784, 1810, 1751, 1716, 1654, 1521, 1498, 1455, 1367,
1322, 1284, 1257, 1218, 1166, 1141, 1108, 1083, 1047, 1004, 993, 954, 931, 894, 865,
831, 775, 755, 692, 665, 628, 511, 457, 408(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 10.3, 10.5, 12.8, 13.0, 14.2, 15.3, 15.5, 15.7, 15.8, 16.0,
16.6, 16.8, 18.8, 18.9, 19.9, 21.1, 21.2, 22.2, 22.3, 22.4, 26.0, 26.2, 28.2, 28.6, 30.5, 32.8,
33.1, 33.4, 33.5, 37.9, 38.1, 38.9, 40.2, 42.8, 42.9, 46.7, 46.8, 47.7, 48.0, 48.5, 49.4, 49.5,
49.8, 49.9, 51.0, 51.1, 65.9, 69.4, 70.3, 73.8, 74.1, 75.9, 76.0, 76.2, 78.3, 78.4, 78.5, 79.1,
79.2, 82.4, 82.5, 84.3, 84.5, 84.6, 103.7, 127.7, 127.8, 127.9, 129.1, 129.2, 129.3, 130.9,
131.6, 131.7, 132.2, 141.8, 141.9, 143.1, 143.2, 144.0, 144.1, 144.2, 144.5, 144.7, 144.8,
144.9, 153.8, 154.1, 154.4, 164.6, 164.7, 166.3, 168.8, 169.0, 169.3, 171.7, 171.8, 172.1,
203.8, 203.9

I-187

MS(FAB):871+(M+H+). HRMS(FAB):calcd for C44H67N6O12 871.4817 found 871.4816
IR(KBr):3384, 3060, 2975, 2937, 2879, 2784, 1810, 1751, 1716, 1673, 1614, 1585, 1535,
1496, 1455, 1411, 1378, 1305, 1284, 1257, 1234, 1166, 1141, 1108, 1083, 1047, 1004,
993, 952, 931, 898, 863, 835, 761, 682, 613, 574, 532, 457, 414(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.7, 14.3, 15.2, 15.5, 15.7, 18.8, 19.9, 21.2, 22.2, 26.1,
28.2, 33.0, 37.9, 38.7, 40.2, 41.8, 47.7, 49.7, 51.0, 65.9, 70.3, 75.7, 78.3, 78.4, 78.5, 82.6,
85.2, 103.7, 123.8, 126.4, 128.7, 129.5, 137.1, 139.5, 142.0, 152.4, 154.5, 166.0, 169.4,
173.1, 203.8

I-188

MS(FAB):771+(M+H+). HRMS(FAB):calcd for C38H67N4O12 771.4755 found 771.4747
IR(KBr):3424, 2975, 2938, 2879, 2825, 2780, 1812, 1751, 1716, 1675, 1519, 1457, 1380,
1363, 1322, 1284, 1257, 1232, 1166, 1141, 1110, 1083, 1047, 1004, 993, 952, 900, 862,
835, 802, 773, 755, 694, 632, 574, 514, 453, 433, 418(cm-1)
13C-NMR(CDCl3):δ(ppm)10.4, 13.0, 14.3, 15.3, 15.6, 16.4, 18.8, 19.9, 21.2, 22.4, 26.4,
28.2, 33.2, 36.8, 38.0, 40.2, 45.2, 47.6, 49.7, 51.1, 57.9, 65.8, 69.5, 70.3, 76.2, 78.4, 78.5,
78.6, 82.5, 84.6, 103.7, 154.0, 166.5, 169.1, 172.1, 204.0

I-189

MS(FAB):871+(M+H+). HRMS(FAB):calcd for C44H67N6O12 871.4817 found 871.4827
IR(KBr):3428, 3062, 2975, 2937, 2879, 2784, 1810, 1751, 1716, 1670, 1619, 1583, 1540,
1496, 1455, 1359, 1319, 1284, 1257, 1234, 1166, 1141, 1110, 1081, 1047, 1006, 993, 952,
900, 835, 800, 771, 686, 630, 572, 539, 466(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.7, 14.3, 15.2, 15.6, 15.7, 18.8, 19.8, 21.2, 22.2, 26.2,
28.3, 33.1, 37.8, 38.8, 40.2, 43.8, 47.6, 49.7, 51.0, 65.8, 69.5, 70.3, 75.8, 78.2, 78.5, 82.4,
85.0, 103.7, 115.3, 121.8, 125.9, 127.9, 132.2, 149.1, 154.1, 155.4, 159.8, 166.4, 169.4,
174.8, 203.9

III ( 12 )

I-190

MS(FAB):729+(M+H+). HRMS(FAB):calcd for C35H61N4O12 729.4286 found 729.4285
IR(KBr): 3416, 2972, 2938, 2879, 2783, 1809, 1752, 1669, 1555, 1457, 1380, 1303, 1284,
1257, 1234, 1166, 1110, 1078, 1048, 987, 932, 893, 776, 695, 616, 529, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.9, 14.2, 15.4, 15.9, 18.8, 19.9, 21.2, 22.3, 26.4, 28.2,
32.9, 35.9, 38.1, 40.1, 47.9, 49.1, 51.0, 65.9, 69.4, 70.2, 74.0, 76.0, 78.5, 79.4, 82.9, 84.7,
103.8, 154.5, 157.4, 165.0, 169.2, 203.8

I-191

MS(FAB):772+(M+H+). HRMS(FAB): calcd for C37H66N5O12 772.4708 found 772.4709
IR(KBr): 3435, 2972, 2938, 2880, 2786, 1809, 1752, 1716, 1662, 1525, 1457, 1364, 1322,
1305, 1283, 1259, 1216, 1166, 1110, 1078, 1048, 987, 931, 895, 833, 775, 695, 622, 591,
560, 529, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.2, 15.5, 15.7, 18.6, 19.8, 21.2, 22.3, 26.5, 28.2,
32.9, 37.2, 38.3, 40.2, 44.8, 47.8, 49.6, 51.0, 58.5, 65.8, 69.4, 70.3, 74.9, 76.2, 78.3, 79.3,
82.9, 84.8, 103.8, 154.2, 158.4, 166.0, 169.1, 203.7

I-192

MS(SI):716+(M+H+). HRMS(SI):calcd for C34H58N3O13 716.3966 found 716.3969
IR(KBr): 3439, 2973, 2938, 2880, 1809, 1746, 1632, 1514, 1457, 1381, 1324, 1284, 1237,
1165, 1110, 1077, 1049, 1006, 989, 957, 931, 908, 779(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.2, 15.5, 15.7, 18.7, 19.8, 21.2, 22.4, 26.5, 28.3,
33.0, 38.2, 40.1, 47.8, 49.3, 51.1, 52.1, 65.9, 69.4, 70.3, 74.3, 76.3, 78.4, 79.2, 82.9, 84.7,
103.7, 154.5, 156.7, 166.0, 169.1, 203.9

IV ( 10 )

I-193

MS(FAB):701+(M+H+).HRMS(FAB):calcd for C34H57N2O13 701.3861. found 7013866.
IR(KBr):3448, 2974, 2938, 2880, 2786, 1812, 1752, 1718, 1636, 1457, 1380, 1361, 1324,
1304, 1284, 1257, 1210, 1167, 1142, 1108, 1084, 1047, 1004, 993, 953, 932, 889, 860,
835, 773, 693, 631, 582, 566, 530, 512, 455, 432(cm-1).
13C-NMR(CDCl3):δ(ppm)10.4, 13.1, 14.3, 15.2, 15.9, 18.8, 19.7, 21.1, 22.4, 26.7, 28.1,
33.2, 38.2, 40.2, 47.8, 49.6, 51.1, 51.5, 65.8, 69.4, 70.3, 76.3, 78.4, 79.4, 82.5, 84.7, 103.8,
154.3, 166.1, 169.0, 170.5, 204.0

I-194

MS(SI):805+(M+H+).HRMS(SI):calcd for C42H65N2O13 805.4483 found 805.4486
IR(KBr):3447, 2924, 2877, 2851, 2785, 1810, 1752, 1653, 1636, 1628, 1604, 1569, 1560,
1542, 1508, 1497, 1456, 1381, 1362, 1323, 1304, 1284, 1258, 1167, 1142, 1108, 1084,
1047, 1004, 993, 953, 932, 891, 860, 834, 800, 773, 748, 700, 632, 567, 529, 512, 455,
432, 411(cm-1)
13C-NMR(CDCl3):δ(ppm)10.4, 13.2, 14.3, 15.3, 15.8, 18.8, 19.7, 21.1, 22.5, 26.7, 28.2,
29.7, 30.1, 32.1, 38.3, 40.2, 47.8, 49.7, 51.1, 64.0, 65.9, 69.5, 70.3, 70.5, 76.4, 78.5, 79.5,
82.5, 84.8, 103.8, 126.0, 128.4, 128.5, 141.1, 154.3, 166.0, 169.1, 170.1, 204.1


V ( 16 )

I-195

MS(FAB):730+(M+H+). HRMS(FAB):calcd for C35H60N3O13 730.4126 found 730.4122
IR(CHCl3):3598, 3022, 3004, 2934, 1800, 1752, 1712, 1599, 1515, 1454, 1381, 1229,
1227, 1200, 1166, 1108, 1072, 1047, 991(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 12.9, 14.0, 15.3, 15.5, 18.5, 19.5, 20.9, 22.1, 25.8, 27.9,
32.7, 37.9, 40.0, 42.0, 47.5, 49.2, 50.8, 51.7, 65.5, 69.2, 70.0, 71.6, 76.1, 78.1, 78.7, 82.7,
84.2, 103.5, 153.7, 157.0, 165.1, 168.8, 203.7

I-196

MS(FAB):790+(M+H+). HRMS(FAB):calcd for C41H64N3O12 790.4490 found 790.4487
IR(CHCl3):3390, 3022, 3008, 2974, 2934, 2872, 1805, 1751, 1730, 1656, 1513, 1495,
1454, 1375, 1361, 1305, 1251, 1236, 1230, 1227, 1201, 1166, 1139, 1108, 1072, 1045,
1006, 989, 951(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 12.9, 14.0, 15.5, 15.6, 18.5, 19.6, 21.0, 22.1, 25.7, 28.0,
32.7, 38.0, 40.0, 41.4, 42.8, 47.5, 49.3, 50.9, 65.6, 69.3, 70.1, 71.6, 76.0, 78.2, 78.7, 82.9,
84.6, 103.6, 126.4, 128.3, 128.9, 135.7, 153.8, 165.7, 168.9, 171.1, 203.7

I-197

MS(FAB):757+(M+H+). HRMS(FAB):calcd for C37H65N4O12 757.4599 found 757.4603
IR(CHCl3):3372, 3020, 2972, 2934, 2870, 2780, 1798, 1751, 1715, 1665, 1523, 1455,
1382, 1360, 1305, 1282, 1232, 1229, 1199, 1167, 1108, 1072, 1046, 1006, 990, 951, 930,
908(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 12.8, 14.0, 15.1, 15.5, 18.5, 19.5, 20.9, 22.1, 25.9, 28.0,
32.7, 37.9, 38.9, 40.0, 45.6, 47.5, 49.3, 50.8, 62.8, 65.5, 69.2, 70.0, 71.7, 76.1, 78.1, 78.8,
82.6, 84.4, 103.5, 154.0, 165.0, 168.8, 170.4, 203.7

I-198

MS(FAB):832+(M+H+). HRMS(FAB):calcd for C44H70N3O12 832.4960 found 832.4952
IR(CHCl3):3398, 3024, 2976, 2938, 2874, 1806, 1752, 1717, 1651, 1602, 1513, 1455,
1382, 1362, 1305, 1283, 1257, 1231, 1167, 1139, 1108, 1073, 1045, 1006, 990, 951,
908(cm-1)
13C-NMR(CDCl3):δ(ppm)10.0, 12.8, 14.0, 15.4, 18.4, 19.6, 20.9, 22.0, 25.4, 25.7, 28.3,
30.9, 32.6, 35.4, 35.8, 37.9, 39.8, 41.6, 47.4, 49.3, 50.8, 65.6, 69.0, 69.9, 71.5, 75.9, 78.2,
78.6, 82.8, 84.4, 103.4, 125.2, 127.9, 128.2, 142.3, 153.6, 165.6, 168.9, 173.4, 203.6

I-199

MS(FAB):791+(M+H+). HRMS(FAB):calcd for C40H63N4O12 791.4442 found 791.4445
IR(CHCl3):3388, 3016, 2970, 2934, 2872, 1801, 1752, 1715, 1661, 1593, 1571, 1516,
1454, 1382, 1360, 1323, 1305, 1283, 1257, 1228, 1166, 1140, 1108, 1073, 1047, 1006,
990, 951(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.1, 15.5, 15.6, 18.6, 19.7, 21.0, 22.3, 25.9, 28.1,
32.8, 38.1, 40.1, 40.7, 45.2, 47.6, 49.4, 51.0, 65.7, 69.4, 70.2, 71.7, 76.3, 78.3, 78.9, 83.0,
84.6, 103.6, 121.6, 123.7, 136.5, 149.1, 154.0, 155.9, 165.4, 168.9, 169.7, 203.9

I-200

MS(FAB):847+(M+H+). HRMS(FAB):calcd for C44H71N4O12 847.5068 found 847.5067
IR(CHCl3):3384, 2970, 2934, 2868, 2782, 1804, 1751, 1715, 1663, 1512, 1454, 1382,
1360, 1305, 1283, 1256, 1231, 1227, 1166, 1108, 1073, 1046, 991, 950(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.0, 15.3, 15.5, 18.5, 19.6, 21.0, 22.2, 25.7, 27.9,
32.6, 34.4, 37.9, 40.0, 40.1, 42.1, 47.5, 49.2, 50.8, 65.6, 69.3, 70.1, 70.7, 71.7, 76.1, 78.2,
78.8, 82.7, 84.4, 103.6, 125.7, 127.9, 129.2, 139.3, 153.9, 165.2, 168.8, 171.7, 203.7

I-201

MS(FAB):804+(M+H+). HRMS(FAB):calcd for C42H66N3O12 804.4646 found 804.4642
IR(CHCl3):3392, 3022, 2970, 2934, 2872, 1805, 1752, 1716, 1651, 1515, 1454, 1382,
1361, 1305, 1283, 1256, 1228, 1166, 1139, 1108, 1073, 1045, 1006, 990, 951, 929,
908(cm-1)
13C-NMR(CDCl3):δ(ppm)10.0, 12.9, 14.0, 15.5, 18.5, 19.6, 21.0, 22.0, 25.7, 28.0, 31.5,
32.6, 37.2, 37.9, 40.0, 41.6, 47.5, 49.3, 50.8, 65.6, 69.3, 70.1, 71.6, 76.0, 78.2, 78.7, 82.9,
84.4, 103.6, 125.6, 128.0, 128.2, 141.1, 153.6, 165.5, 168.8, 172.4, 203.7

I-202

MS(FAB):818+(M+H+). HRMS(FAB):calcd for C43H68N3O12 818.4803 found 818.4801
IR(CHCl3):3400, 3029, 3016, 2977, 2939, 2878, 2788, 1806, 1752, 1717, 1652, 1602,
1513, 1455, 1383, 1361, 1323, 1305, 1284, 1257, 1205, 1167, 1140, 1109, 1074, 1046,
1006, 991, 952, 931, 916(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 12.9, 14.1, 15.5, 18.5, 19.7, 21.0, 22.1, 25.7, 27.6, 28.0,
32.6, 35.1, 35.6, 38.0, 40.0, 41.5, 47.5, 49.4, 50.9, 65.7, 69.3, 70.1, 71.7, 76.1, 78.2, 78.8,
82.9, 84.5, 103.6, 125.4, 128.0, 128.4, 142.0, 153.7, 165.6, 169.0, 173.2, 203.6

I-203

MS(FAB):856+(M+H+). HRMS(FAB):calcd for C44H66N5O12 856.4708 found 856.4713
Anal Calcd for C44H65N5O12(H2O)1.2:C 60.22, H 7.74, N 7.98 Found C 60.17, H 7.50, N
7.82
IR(KBr):3397, 2972, 2937, 2878, 2784, 1809, 1751, 1716, 1670, 1500, 1455, 1380, 1322,
1305, 1284, 1258, 1233, 1219, 1167, 1141, 1109, 1075, 1046, 1005, 992, 954, 930, 913,
866, 832, 799, 769, 754, 693, 666, 622, 580, 531, 512, 456, 407(cm-1)
13C-NMR(CDCl3):δ(ppm)9.9, 12.9, 14.1, 15.4, 15.5, 18.5, 19.7, 21.0, 22.0, 25.7, 28.0, 31.5,
32.6, 36.3, 37.9, 40.0, 41.8, 47.5, 49.4, 50.8, 65.7, 69.3, 70.1, 71.6, 76.0, 78.2, 78.7, 82.9,
84.5, 103.6, 127.8, 128.8, 131.7, 141.6, 143.0, 143.9, 144.0, 144.6, 153.7, 165.7, 169.0,
172.0, 203.7

I-204

MS(FAB):870+(M+H+). HRMS(FAB):calcd for C45H68N5O12 870.4864 found 870.4861
Anal Calcd for C45H67N5O12(H2O)0.7:C 61.23, H 7.81, N 7.93 Found C 61.25, H 7.62, N
7.78
IR(KBr):3400, 2972, 2937, 2877, 2784, 1809 1751, 1716, 1669 1499, 1455, 1380, 1323,
1304, 1284, 1257, 1233, 1219, 1167, 1141, 1109, 1075, 1047, 1005, 992, 955, 930, 913,
896, 866, 832, 798, 779, 754, 693, 665, 622, 581, 561, 530, 512, 456, 426, 409(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.2, 15.6, 15.7, 18.6, 19.8, 21.1 22.3, 25.9, 27.3,
28.2, 32.8, 35.4, 35.7, 38.1, 40.2, 41.9, 47.7, 49.5, 51.0, 65.8, 69.5, 70.3, 71.9, 76.2, 78.4,
78.9, 83.1, 84.7, 103.8, 127.8, 129.0, 131.9, 141.7, 143.2, 144.0, 144.7, 145.0, 153.9,
165.9, 169.2, 173.1, 203.8

I-205

MS(FAB):855+(M+H+). HRMS(FAB):calcd for C45H67N4O12 855.4755 found 855.4752
Anal Calcd for C45H66N4O12(H2O)0.3:C 62.82, H 7.80, N 6.51 Found C 62.87, H 7.78, N
6.35
IR(KBr):3397, 3064, 2972, 2937, 2877, 2784, 1809, 1751, 1716, 1671, 1592, 1568, 1509,
1455, 1380, 1322, 1304, 1284, 1257, 1234, 1167, 1141, 1109, 1075, 1047, 1005, 992, 953,
931, 914, 842, 798, 766, 693, 623, 582, 554, 512, 455, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 13.0, 14.3, 15.6, 18.6, 19.9, 21.2, 22.2, 25.8, 27.4, 28.2,
32.7, 35.2, 38.1, 40.2, 42.1, 47.7, 49.6, 51.0, 65.8, 69.5, 70.3, 71.7, 76.1, 78.4, 78.9, 83.1,
84.7, 103.8, 120.5, 123.9, 126.3, 127.6, 128.9, 129.9, 147.4, 148.1, 150.2, 153.8, 165.9,
169.2, 172.1, 203.8

I-206

MS(FAB):858+(M+H+). HRMS(FAB):calcd for C45H72N5O11 858.5228 found 858.5218
Anal Calcd for C45H71N5O11(H2O)0.8: C 61.95, H 8.39, N 8.03 Found C 61.93, H 8.22, N
8.01
IR(KBr):3412, 3063, 3032, 2973, 2938, 2876, 2838, 1746, 1705, 1676, 1621, 1586, 1498,
1455, 1406, 1379, 1331, 1294, 1254, 1175, 1116, 1092, 1065, 1025, 984, 937, 891, 868,
828, 783, 767, 755, 739, 698, 667, 609, 518, 470, 407(cm-1)
13C-NMR(CDCl3):δ(ppm)10.5, 14.1, 14.4, 14.9, 16.3, 19.5, 20.4, 21.2, 22.2, 27.3, 28.3,
31.6, 37.6, 40.2, 40.7, 46.7, 49.9, 51.3, 53.4, 61.5, 65.8, 69.5, 70.3, 71.4, 77.8, 78.9, 80.7,
103.9, 127.8, 129.3, 131.6, 141.8, 143.1, 143.8, 144.4, 144.9, 168.1, 169.2, 171.5, 204.2

I-207

MS(FAB):757+(M+H+). HRMS(FAB):calcd for C37H65N4O12 757.4599 found 757.4597
Anal Calcd for C37H64N4O12(H2O)0.3:C 58.30, H 8.54, N 7.35 Found C 58.30, H 8.41, N
7.22
IR(KBr): 3450, 2974, 2939, 2879 2785, 1812, 1752, 1717, 1659, 1457, 1397, 1380, 1360,
1323, 1304, 1284, 1258, 1233, 1218, 1165, 1109, 1078, 1049, 1005, 992, 953, 932, 908,
835, 774, 693, 629, 604, 574, 527, 456, 432(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.3, 15.6, 15.8, 18.7, 19.9, 21.2, 22.4, 26.2, 28.2,
33.0, 37.7, 38.2, 40.2, 43.7, 44.1, 47.8, 49.6, 51.1, 65.9, 69.5, 70.4, 70.9, 76.3, 78.5, 79.2,
82.8, 84.5, 103.9, 154.4, 164.6, 169.2, 173.7, 204.0

I-208

MS(FAB):899+(M+H+). HRMS(FAB):calcd for C46H71N6O12 899.5130 found 899.5135
Anal Calcd for C46H70N6O12(H2O)0.4:C 60.96, H 7.87, N 9.27 Found C 60.91, H 7.77, N
9.26
IR(KBr): 3444, 2973, 2938, 2878, 2785, 1811, 1751, 1716, 1654, 1498, 1455, 1410, 1379,
1323, 1305, 1284, 1258, 1218, 1165, 1109, 1076, 1048, 1005, 992, 954, 931, 894, 865,
832, 773, 755, 693, 666, 620, 581, 558, 528, 514, 455, 408(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.0, 14.3, 15.6, 15.8, 18.7, 19.9, 21.2, 22.4, 26.1, 28.2,
31.3, 33.0, 34.1, 37.9, 38.2, 40.2, 43.8, 44.2, 47.8, 49.6, 51.1, 65.9, 69.5, 70.4, 70.8, 76.3,
78.5, 79.1, 82.8, 84.5, 103.8, 127.7, 129.2, 131.9, 141.8, 143.2, 144.2, 144.7, 144.9, 154.3,
164.6, 169.2, 174.5, 204.0

I-209

MS(FAB):858+(M+H+). HRMS(FAB):calcd for C43H64N5O13 858.4501 found 858.4508
Anal Calcd for C43H63N5O13(H2O)0.5:C 59.57, H 7.44, N 8.07 Found C 59.55, H 7.37, N
7.91
IR(KBr): 3427, 3070, 2972, 2937, 2878, 2784, 1807, 1751, 1716, 1683, 1612, 1576, 1540,
1494, 1474, 1456, 1380, 1359, 1301, 1259, 1222, 1165, 1141, 1109, 1076, 1048, 1005,
992, 953, 932, 900, 863, 830, 758, 693, 622, 557, 528, 455, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.3, 15.5, 15.7, 18.8, 19.8, 21.1, 22.4, 26.2, 28.2,
33.1, 38.2, 39.4, 40.2, 47.8, 49.7, 51.1, 65.9, 69.5, 69.6, 70.4, 71.5, 76.3, 78.4, 79.2, 82.9,
84.7, 103.8, 111.7, 122.9, 130.0, 135.4, 143.9, 144.0, 145.7, 153.7, 154.3, 165.3, 168.1,
169.0, 203.9

I-210

MS(FAB):858+(M+H+). HRMS(FAB):calcd for C43H64N5O13 858.4501 found 858.4506
Anal Calcd for C43H63N5O13(H2O)0.4: C 59.69, H 7.43, N 8.09 Found C 59.72, H 7.34, N
7.96
IR(KBr): 3434, 2973, 2937, 2878, 2784, 1808, 1751, 1715, 1684, 1617, 1533, 1497 1455,
1378, 1302, 1257, 1220, 1198, 1166, 1109, 1075, 1047, 1005, 992, 954, 930, 914, 875,
830, 799, 778, 755, 693, 658, 618, 549, 456, 415(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.1, 14.3, 15.6, 18.8, 19.8, 21.2, 22.3, 26.1, 28.2, 33.0,
38.2, 40.2, 40.3, 47.7, 49.7, 51.1, 65.9, 67.7, 69.5, 70.3, 71.7, 76.3, 78.4, 79.1, 82.9, 84.7,
103.8, 108.5, 123.2, 130.8, 139.5, 142.9, 144.5, 145.1, 154.1, 158.6, 165.8, 167.4, 169.2,
204.0

I-211

MS(FAB):888+(M+H+). HRMS(FAB):calcd for C44H66N5O14 888.4606 found 888.4608
Anal Calcd for C44H65N5O14(H2O): C 58.33, H 7.45, N 7.73 Found C 58.38, H 7.32, N
7.33
IR(KBr): 3419, 3063, 2973, 2938, 2878, 2785, 1807, 1751, 1695, 1529, 1456, 1382, 1322,
1305, 1284, 1256, 1235, 1167, 1142, 1109, 1075, 1047, 1005, 992, 953, 932, 902, 829,
779, 755, 681, 620, 567, 464(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.3, 15.6, 15.8, 18.7, 19.9, 21.2, 22.3, 26.0, 28.5,
31.5, 33.0, 37.1, 38.2, 40.3, 41.5, 47.8, 49.6, 51.1, 65.8, 69.4, 70.3, 71.8, 76.3, 78.5, 79.1,
83.2, 85.0, 103.8, 115.8, 116.1, 123.1, 124.4, 124.9, 137.5, 154.2, 156.1, 165.9, 169.3,
173.2, 203.9

I-212

MS(FAB):871+(M+H+). HRMS(FAB):calcd for C44H67N6O12 871.4817 found 871.4811
Anal Calcd for C44H66N6O12(H2O)0.5: C 60.05, H 7.67, N 9.55 Found C 60.11, H 7.72, N
9.45
IR(KBr): 3392, 2972, 2937, 2878, 2784, 1806, 1750, 1716, 1672, 1598, 1548, 1516, 1455,
1407, 1380, 1323, 1304, 1285, 1257, 1233, 1169, 1141, 1109, 1074, 1047, 1005, 992, 951,
941, 913, 834, 813, 778, 755, 710, 693, 627, 555, 512, 456(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.2, 15.6, 18.5, 19.8, 21.1, 22.2, 25.8, 28.3, 32.7,
37.1, 38.1, 40.2, 42.3, 43.5, 47.7, 49.5, 51.0, 65.8, 69.5, 70.3, 71.5, 76.1, 78.4, 78.9, 83.2,
84.9, 103.9, 116.0, 123.4, 130.5, 131.9, 138.4, 138.8, 146.5, 147.4, 166.2, 169.3, 169.6,
203.7

I-213

MS(FAB):870+(M+H+). HRMS(FAB):calcd for C45H68N5O12 870.4864 found 870.4879
Anal Calcd for C45H67N5O12(H2O)0.5: C 61.49, H 7.80, N 7.97 Found C 61.48, H 7.59, N
7.80
IR(KBr): 3396, 2972, 2937, 2878, 2784, 1808, 1751, 1716, 1672, 1592, 1550, 1508, 1455,
1380, 1363, 1322, 1304, 1284, 1257, 1218, 1168, 1141, 1109, 1075, 1047, 1005, 992, 952,
923, 835, 778, 709, 695, 620, 580, 554, 530, 512, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.2, 15.6, 18.6, 19.8, 21.2, 22.3, 25.8, 28.2, 32.7,
37.9, 38.1, 40.2, 42.2, 46.2, 47.7, 49.5, 51.0, 65.9, 69.5, 70.3, 71.6, 76.2, 78.4, 78.9, 83.2,
84.8, 103.8, 105.9, 118.4, 120.9, 122.6, 131.8, 146.0, 146.5, 154.1, 166.1, 169.2, 170.4,
203.8

I-214

MS(FAB):872+(M+H+). HRMS(FAB):calcd for C44H66N5O13 872.4657 found 872.4661
Anal Calcd for C44H65N5O13: C 59.98, H 7.55, N 7.95 Found C 59.99, H 7.42, N 7.67
IR(KBr): 3397, 2973, 2937, 2878, 2784, 1809, 1751, 1716, 1653, 1521, 1500, 1455, 1379,
1323, 1304, 1284, 1257, 1234, 1167, 1140, 1109, 1074, 1047, 1005, 992, 954, 931, 902,
867, 834, 779, 755, 680, 621 581, 554, 512, 455, 407(cm-1)
13C-NMR(CDCl3):δ(ppm)10.0, 10.1, 13.0, 14.3, 15.6, 15.7, 18.6, 18.7, 19.9, 21.2, 22.2,
25.9, 28.2, 32.8, 38.1, 40.2, 42.0, 42.1, 42.8, 43.2, 47.6, 47.7, 49.6, 51.0, 65.9, 69.5, 70.3,
70.6, 70.7, 71.5, 71.6, 76.1, 76.2, 78.4, 78.5, 78.8, 79.0, 83.1, 83.2, 84.9, 103.8, 126.0,
128.6, 128.8, 129.2, 129.3, 142.4, 143.1, 144.5, 144.9, 145.0, 145.9, 146.0, 154.0, 166.1,
169.1, 169.2, 172.2, 203.8

I-215

MS(FAB):884+(M+H+). HRMS(FAB):calcd for C46H70N5O12 884.5021 found 884.5013
Anal Calcd for C46H69N5O12(H2O)0.9: C 61.37, H 7.93, N 7.78 Found C 61.35, H 7.87, N
7.68
IR(KBr): 3396, 2972, 2937, 2877, 2784 1808, 1752, 1717, 1671, 1592, 1551, 1509, 1455,
1380, 1322, 1304, 1284, 1256, 1218, 1167, 1141, 1109, 1076, 1048, 1005, 992, 953, 923,
835, 779, 709, 620, 581, 555, 512(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.2, 15.5, 15.6, 18.6, 19.8, 21.2, 22.3, 25.8, 28.2,
32.7, 38.1, 40.2, 42.1, 43.0, 47.7, 49.5, 51.0, 53.2, 65.9, 69.5, 70.3, 71.7, 76.2, 78.4, 79.0,
83.3, 84.8, 103.9, 105.6, 118.7, 120.9, 123.2, 123.3, 131.8, 146.0, 146.5, 154.1, 166.0,
169.2, 174.3, 203.8

I-216

MS(FAB):884+(M+H+). HRMS(FAB):calcd for C46H70N5O12 884.5021 found 884.5023
Anal Calcd for C46H69N5O12(H2O)1.1: C 61.13, H 7.94, N 7.75 Found C 61.08, H 7.77, N
7.62
IR(KBr): 3402, 2972, 2937, 2878, 2784, 1808, 1751, 1716, 1671, 1592, 1551, 1507, 1455,
1419, 1380, 1322, 1304, 1284, 1256, 1218, 1167, 1141, 1109, 1076, 1048, 1005, 993, 953,
924, 778, 709, 620, 581, 513, 457(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.2, 15.6, 15.7, 18.6, 19.8, 21.2, 22.4, 25.8, 28.2,
32.8, 38.2, 40.2, 41.9, 42.6, 47.6, 49.5, 51.0, 52.8, 65.9, 69.5, 70.3, 71.9, 76.4, 78.4, 78.9,
83.3, 84.8, 103.8, 106.2, 118.7, 120.7, 122.6, 123.4, 131.8, 132.0, 146.0, 146.4, 154.1,
166.2, 169.1, 174.3, 203.8

I-217

MS(FAB):854+(M+H+). HRMS(FAB):calcd for C44H64N5O12 854.4551 found 854.4550
Anal Calcd for C44H63N5O12(H2O)0.9: C 60.73, H 7.51, N 8.05 Found C 60.71, H 7.35, N
7.80
IR(KBr): 3400, 2973, 2937, 2878, 2784, 1807, 1752, 1717, 1670, 1628, 1507, 1455, 1378,
1325, 1304, 1285, 1257, 1233, 1220, 1167, 1142, 1109, 1075, 1047, 1006, 991, 955, 932,
913, 903, 866, 831, 780, 754, 693, 622, 581, 563, 527, 454, 408(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 13.1, 14.3, 15.6, 15.8, 18.7, 19.9, 21.2, 22.3, 25.9, 28.2,
32.8, 38.2, 40.2, 42.5, 47.7, 49.6, 51.0, 65.9, 69.5, 70.3, 72.0, 76.2, 78.4, 78.8, 83.4, 85.0,
96.13, 103.8, 124.2, 128.9, 129.7, 130.1, 137.5, 139.7, 143.3, 143.5, 144.9, 145.3, 154.3,
165.8, 166.1, 169.1, 203.9

I-218

MS(FAB):870+(M+H+). HRMS(FAB):calcd for C45H68N5O12 870.4864 found 870.4874
Anal Calcd for C45H67N5O12(H2O)0.6: C 61.36, H 7.80, N 7.95 Found C 61.65, H 7.69, N
7.65
IR(KBr): 3396, 3070, 2972, 2937, 2878, 2784, 1806, 1751, 1716, 1671, 1601, 1558, 1544,
1515, 1455, 1425, 1379, 1322, 1304, 1284, 1257, 1219, 1168, 1141, 1109, 1075, 1047,
1005, 992, 953, 930, 914, 830, 782, 755, 738, 695, 620, 530, 455, 430, 404(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.2, 15.6, 18.6, 19.8, 21.1, 22.3, 25.8, 28.2, 32.7,
37.7, 38.1, 40.2, 42.2, 46.2, 47.7, 49.5, 51.0, 65.8, 69.5, 70.3, 71.6, 76.2, 78.4, 78.9, 83.2,
84.9, 103.8, 106.1, 119.3, 119.8, 121.6, 122.8, 143.6, 149.7, 154.1, 166.1, 169.2, 170.2,
203.7

I-219

MS(FAB):857+(M+H+). HRMS(FAB):calcd for C43H65N6O12 857.4660 found 857.4664
Anal Calcd for C43H64N6O12(H2O)0.9: C 59.15, H 7.60, N 9.62 Found C 59.15, H 7.50, N
9.47
IR(KBr): 3397, 2972, 2937, 2878, 2784, 1808, 1751, 1716, 1682, 1605, 1583, 1515, 1482,
1455, 1406, 1379, 1360, 1316, 1284, 1256, 1234, 1216, 1167, 1141, 1109, 1076, 1047,
1005, 992, 953, 931, 915, 827, 770, 753, 693, 621, 556, 529, 455, 433(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.3, 15.6, 18.6, 19.8, 21.2, 22.4, 25.9, 28.2, 32.9,
38.2, 40.2, 41.3, 47.6, 47.7, 49.6, 51.1, 65.9, 69.5, 70.3, 71.9, 76.3, 78.4, 79.0, 83.2, 84.9,
103.8, 106.0, 116.0, 131.6, 133.4, 141.2, 143.6, 144.7, 145.0, 154.3, 165.9, 169.1, 170.0,
203.9

I-220

MS(FAB):843+(M+H+). HRMS(FAB):calcd for C44H67N4O12 843.4755 found 843.4764
Anal Calcd for C44H66N4O12(H2O)0.4: C 62.16, H 7.92, N 6.59 Found C 62.19, H 8.01, N
6.45
IR(KBr): 3397, 3053, 2972, 2937, 2878, 2784, 1809, 1751, 1717, 1671, 1512, 1456, 1380,
1361, 1313, 1284, 1258, 1233, 1168, 1141, 1109, 1075, 1047, 1005, 992, 953, 931, 914,
835, 765, 742, 717, 694, 622, 581, 556, 513, 455, 427(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.1, 14.2, 15.5, 15.6, 18.6, 19.8, 21.2, 22.3, 25.8, 28.2,
32.7, 36.8, 38.2, 40.2, 41.9, 42.6, 47.7, 49.6, 51.0, 65.9, 69.5, 70.3, 71.6, 76.3, 78.4, 79.0,
83.2, 84.7, 101.1, 103.8, 109.7, 119.1, 120.6, 121.2, 128.2, 128.5, 128.6, 136.0, 153.9,
165.9, 169.1, 170.8, 203.9

I-221

MS(FAB):909+(M+Na+). HRMS(FAB):calcd for C46H70N4O13Na 909.4837 found
909.4839
IR(KBr): 3397, 3051, 2973, 2937, 2878, 2785, 1809, 1751, 1716, 1672, 1615, 1514, 1455,
1379, 1361, 1325, 1284, 1257, 1233, 1168, 1141, 1109, 1077, 1047, 1005, 992, 952, 931,
902, 834, 779, 742, 693, 622, 581, 563, 529, 455, 429(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.1, 14.2, 15.5, 15.7, 18.6, 19.8, 21.1, 22.2, 25.8, 28.2,
32.7, 36.6, 38.1, 40.2, 41.9, 42.3, 47.7, 49.5, 51.0, 57.0, 65.8, 66.3, 69.5, 70.2, 71.6, 76.2,
78.3, 79.0, 83.1, 84.6, 103.7, 109.8, 111.3, 119.0, 119.2, 121.6, 127.7, 128.3, 136.5, 153.8,
165.9, 169.0, 170.6, 203.8

I-222

MS(FAB):845+(M+H+). HRMS(FAB):calcd for C42H65N6O12 845.4660 found 845.4666
Anal Calcd for C42H64N6O12(H2O)0.5: C 59.07, H 7.67, N 9.84 Found C 59.15, H 7.75, N
9.59
IR(KBr): 3396, 3057, 2973, 2938, 2878, 2784, 1807, 1751, 1716, 1671, 1599, 1584, 1502,
1455, 1410, 1380, 1362, 1322, 1301, 1286, 1257, 1234, 1196, 1167, 1141, 1109, 1075,
1047, 1005, 992, 953, 931, 913, 835, 801, 776, 755, 692, 634, 512, 456(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.2, 15.6, 18.6, 19.8, 21.1, 22.2, 25.8, 28.2, 32.8,
35.6, 38.1, 39.7, 40.2, 41.9, 47.7, 49.5, 51.0, 65.8, 69.5, 70.3, 71.6, 76.1, 78.4, 78.9, 83.0,
84.7, 103.8, 117.9, 127.5, 135.3, 143.9, 145.0, 147.0, 153.8, 165.9, 169.2, 170.1, 203.8

I-223

MS(FAB):845+(M+H+). HRMS(FAB):calcd for C42H65N6O12 845.4660 found 845.4664
Anal Calcd for C42H64N6O12(H2O)0.8: C 58.70, H 7.69, N 9.78 Found C 58.76 H 7.73, N
9.58
IR(KBr): 3396, 3056, 2973, 2938, 2878, 2784, 1806, 1750, 1716, 1671, 1611, 1517, 1494,
1455, 1415, 1380, 1361, 1320, 1291, 1258, 1233, 1167, 1141, 1109, 1075, 1047, 1005,
992, 953, 932, 903, 835, 780, 755, 692, 626, 582, 566, 512, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.2, 15.5, 15.6, 18.5, 19.8, 21.1, 22.2, 25.8, 28.2,
32.6, 36.0, 38.1, 40.2, 41.5, 42.1, 47.7, 49.5, 51.0, 65.8, 69.5, 70.3, 71.4, 76.1, 78.4, 79.0,
83.3, 84.9, 103.8, 117.8, 118.5, 126.1, 144.5, 146.0, 154.0, 156.2, 166.2, 169.3, 169.6,
203.7

I-224

MS(FAB):844+(M+H+). HRMS(FAB):calcd for C43H66N5O12 844.4708 found 844.4705
Anal Calcd for C43H65N5O12(H2O)0.7: C 60.29, H 7.81, N 8.18 Found C 60.27, H 7.85, N
8.02
IR(KBr): 3396, 3058, 2972, 2937, 2878, 2784, 1807, 1751, 1716, 1671, 1616, 1497, 1456,
1381, 1363, 1327, 1304, 1286, 1258, 1234, 1167, 1141, 1109, 1075, 1047, 1005, 992, 952,
931, 913, 769, 745, 693, 625, 557, 512, 455, 428(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.1, 14.3, 15.5, 18.6, 19.8, 21.2, 22.3, 25.8, 28.3, 32.7,
36.1, 38.2, 40.2, 41.1, 42.2, 47.7, 49.5, 51.0, 65.9, 69.5, 70.3, 71.6, 76.2, 78.4, 79.0, 83.2,
84.8, 103.9, 110.1, 120.0, 121.8, 122.7, 133.8, 143.7, 143.8, 154.0, 166.2, 169.2, 170.0,
203.8

I-225

MS(FAB):844+(M+H+). HRMS(FAB):calcd for C43H66N5O12 844.4708 found 844.4714
Anal Calcd for C43H65N5O12(H2O)0.4: C 60.67, H 7.79, N 8.23 Found C 60.75, H 7.84, N
8.09
IR(KBr): 3396, 3052, 2972, 2938, 2878, 2784, 1808, 1751, 1716, 1671, 1593, 1569, 1510,
1455, 1428, 1380, 1361, 1304, 1284, 1258, 1233, 1168, 1141, 1109, 1075, 1047, 1005,
992, 953, 931, 914, 894, 835, 798, 774, 722, 693, 622, 580, 555, 530, 512, 485, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.2, 15.5, 15.6, 18.6, 19.8, 21.1, 22.2, 25.9, 28.2,
32.8, 36.6, 38.1, 40.2, 40.8, 41.4, 47.7, 49.5, 51.0, 65.8, 69.5, 70.3, 71.6, 76.2, 78.4, 79.0,
82.9, 84.6, 99.2, 103.8, 115.4, 120.6, 128.4, 128.6, 142.4, 147.3, 153.9, 165.7, 169.1,
170.7, 203.9

I-226

MS(FAB):884+(M+H+). HRMS(FAB):calcd for C46H70N5O12 884.5021 found 884.5021
Anal Calcd for C46H69N5O12(H2O): C 61.25, H 7.93, N 7.76 Found C 61.25, H 7.60, N
7.55
IR(KBr): 3396, 2973, 2937, 2878, 2784, 1807, 1751, 1717, 1671, 1592, 1569, 1550, 1514,
1455, 1419, 1380, 1361, 1323, 1303, 1285, 1257, 1234, 1213, 1168, 1141, 1109, 1075,
1046, 1005, 991, 953, 924, 899, 835, 778, 709, 695, 623, 581, 530, 513, 456(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.3, 15.6, 18.6, 19.8, 21.2, 21.5, 22.4, 25.8, 28.2,
32.7, 38.2, 40.2, 42.2, 44.9, 47.7, 49.5, 51.1, 53.6, 65.9, 69.5, 70.3, 71.7, 76.3, 78.5, 78.9,
83.4, 84.9, 103.9, 105.4, 116.4, 120.6, 121.1, 123.4, 131.8, 132.2, 145.9, 146.6, 154.2,
166.0, 169.3, 170.3, 203.8

I-227

MS(FAB):884+(M+H+). HRMS(FAB):calcd for C46H70N5O12 884.5021 found 884.5013
Anal Calcd for C46H69N5O12(H2O)1.1: C 61.13, H 7.94, N 7.75 Found C 61.14, H 7.72, N
7.60
IR(KBr): 3396, 2973, 2937, 2878, 2784, 1807, 1751, 1717, 1671, 1592, 1550, 1513, 1455,
1419, 1380, 1361, 1323, 1303, 1284, 1256, 1234, 1214, 1168, 1141, 1109, 1076, 1047,
1005, 991, 953, 924, 901, 835, 778, 709, 695, 622, 555, 529, 512, 454, 432(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.1, 13.9, 14.3, 15.5, 15.7, 18.6, 19.4, 19.8, 21.2, 21.4,
21.5, 22.3, 25.8, 28.3, 32.8, 38.2, 40.2, 42.3, 44.4, 47.6, 49.5, 51.0, 53.0, 65.9, 69.5, 70.3,
71.7, 76.3, 78.4, 78.9, 83.3, 84.9, 103.8, 105.7, 116.7, 120.3, 120.5, 123.4, 131.7, 132.1,
145.9, 146.4, 154.1, 166.2, 169.1, 170.1, 203.8

I-228

MS(FAB):884+(M+H+). HRMS(FAB):calcd for C46H70N5O12 884.5021 found 884.5018
Anal Calcd for C46H69N5O12(H2O)0.7: C 61.62, H 7.91, N 7.81 Found C 61.64, H 7.80, N
7.68
IR(KBr): 3441, 2972, 2937, 2878, 2784, 1806, 1751, 1716, 1646, 1592, 1570, 1551, 1455,
1380, 1362, 1321, 1304, 1284, 1257, 1217, 1167, 1140, 1109, 1080, 1048, 1005, 992, 953,
923, 897, 834, 779, 709, 620, 581, 528, 455, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 13.2, 14.3, 15.5, 15.7, 15.8, 18.7, 18.8, 19.8, 21.2,
22.4, 22.5, 26.2, 26.3, 28.3, 28.4, 33.0, 34.0, 35.1, 35.6, 36.4, 38.2, 40.2, 45.7, 45.8, 47.7,
47.8, 47.9, 48.4, 49.7, 49.8, 51.1, 65.9, 69.5, 70.2, 70.3, 70.9, 76.4, 78.3, 78.4, 79.0, 79.2,
82.8, 84.7, 103.8, 106.1, 106.3, 118.1, 118.3, 121.3, 122.4, 122.6, 123.5, 131.9, 146.2,
146.3, 146.5, 154.4, 164.9, 165.6, 169.1, 169.2, 170.1, 170.7, 204.0

I-229

MS(FAB):859+(M+H+). HRMS(FAB):calcd for C43H67N6O12 859.4817 found 859.4853
IR(KBr): 3431, 3050, 2972, 2937, 2878, 2785, 1805, 1750, 1716, 1645, 1571, 1492, 1455,
1414, 1380, 1361, 1318, 1290, 1258, 1233, 1219, 1167, 1141, 1110, 1079, 1048, 1005,
992, 953, 933, 897, 834, 780, 755, 694, 631, 589, 566, 512, 455, 427(cm-1)
13C-NMR(CDCl3):δ(ppm)10.4, 13.0, 13.1, 13.9, 14.3, 15.4, 15.6, 18.7, 18.9, 19.4, 19.8,
21.2, 22.4, 26.2, 26.3, 28.5, 33.0, 33.2, 33.6, 34.1, 36.4, 38.1, 38.2, 40.3, 40.9, 41.0, 47.7,
47.9, 48.3, 49.7, 51.1, 65.9, 69.5, 69.8, 70.3, 70.6, 70.7, 76.3, 76.4, 78.4, 78.5, 78.8, 79.2,
82.8, 82.9, 84.7, 84.9, 103.7, 117.9, 118.5, 126.0, 126.2, 144.6, 144.8, 146.1, 146.5, 154.4,
154.6, 156.2, 165.1, 165.7, 169.2, 169.3, 169.4, 170.1, 204.0

I-230

MS(FAB):868+(M+H+). HRMS(FAB):calcd for C45H66N5O12 868.4708 found 868.4716
Anal Calcd for C45H65N5O12(H2O): C 61.00, H 7.62, N 7.90 Found C 60.97, H 7.38, N
7.80
IR(KBr): 3398, 2972, 2937, 2878, 2784, 1809, 1752, 1717, 1668, 1619, 1516, 1501, 1455,
1379, 1324, 1304, 1284, 1257, 1232, 1167, 1140, 1109, 1075, 1047, 1005, 992, 952, 931,
892, 865, 826, 771, 693, 657, 622, 552, 530, 455, 433, 407(cm-1)
13C-NMR(CDCl3):δ(ppm)9.9, 10.3, 13.1, 14.2, 14.3, 15.5, 15.7, 15.8, 17.5, 17.7, 18.6, 19.8,
19.9, 21.1, 22.0, 22.3, 24.9, 25.8, 25.9, 26.2, 28.1, 32.7, 32.8, 38.1, 40.2, 42.3, 42.4, 47.5,
47.6, 49.4, 49.6, 50.9, 51.0, 65.7, 69.4, 70.1, 71.6, 71.8, 75.8, 76.2, 78.2, 78.3, 78.8, 83.0,
84.5, 84.6, 103.5, 103.6, 125.8, 125.9, 128.5, 128.6, 128.9, 141.5, 141.6, 142.8, 142.9,
143.5, 143.6, 144.0, 144.1, 144.6, 144.7, 153.5, 153.6, 165.6, 165.7, 168.5, 168.8, 171.5,
171.6, 203.5

I-231

MS(FAB):868+(M+H+). HRMS(FAB):calcd for C45H66N5O12 868.4708 found 868.4706
Anal Calcd for C45H65N5O12(H2O)1.2: C 60.75, H 7.64, N 7.87 Found C 60.71, H 7.38, N
7.71
IR(KBr): 3398, 2972, 2937, 2877, 2784, 1805, 1752, 1716, 1678, 1629, 1594, 1559, 1497,
1455, 1365, 1321, 1284, 1257, 1217, 1167, 1141, 1109, 1075, 1047, 1006, 992, 953, 932,
918, 837, 779, 709, 678, 620, 599, 582, 530,456, 434, 417(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 13.1, 14.2, 15.6, 15.8, 18.7, 19.9, 21.2, 22.3, 25.9, 28.2,
32.8, 38.2, 40.2, 42.5, 47.7, 49.6, 51.1, 65.9, 69.6, 70.3, 72.0, 76.3, 78.4, 78.9, 83.6, 85.0,
103.8, 106.6, 109.3, 116.8, 122.7, 123.5, 124.2, 130.7, 132.3, 137.5, 146.9, 147.1, 154.4,
165.9, 166.3, 169.1, 203.9

I-232

MS(FAB):868+(M+H+). HRMS(FAB):calcd for C45H66N5O12 868.4708 found 868.4712
IR(KBr): 3396, 3145, 2972, 2937, 2877, 2784, 1807, 1751, 1716, 1672, 1635, 1595, 1559,
1497, 1455, 1367, 1323, 1284, 1258, 1219, 1169, 1141, 1108, 1076, 1047, 1005, 993, 953,
932, 919, 902, 800, 781, 709, 620, 602, 513, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.2, 14.3, 15.6, 15.7, 18.7, 19.4, 19.8, 21.2, 22.4, 25.9,
28.2, 32.9, 38.2, 40.2, 42.0, 47.7, 49.6, 51.1, 65.9, 69.5, 70.3, 71.8, 76.3, 78.4, 79.0, 83.4,
84.8, 103.8, 106.5, 108.6, 120.6, 123.2, 123.4, 125.4, 131.0, 132.5, 132.8, 146.9, 147.0,
154.1, 164.7, 166.3, 169.1, 203.8

I-233

MS(FAB):890+(M+H+). HRMS(FAB):calcd for C41H62N3O12Cl2S 890.3431 found
890.3431
IR(KBr): 3400, 2973, 2937, 2878, 2784, 1808, 1752, 1716, 1675, 1565, 1515, 1455, 1439,
1381, 1361, 1322, 1304, 1284, 1258, 1233, 1196, 1166, 1109, 1075, 1046, 1005, 992, 953,
931, 899, 835, 777, 696, 622, 514, 451, 436, 426, 417, 408(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 13.9, 14.3, 15.6, 15.7, 18.7, 19.4, 19.8, 21.2, 22.4,
26.0, 28.2, 33.0, 36.5, 38.2, 40.2, 41.6, 47.7, 49.7, 51.1, 65.9, 69.6, 70.3, 71.8, 76.3, 78.4,
78.9, 83.2, 84.8, 103.8, 125.3, 127.0, 127.6, 130.0, 133.2, 138.4, 154.1, 166.1, 168.0,
169.1, 204.0

I-234

MS(FAB):792+(M+H+). HRMS(FAB):calcd for C40H62N3O13 792.4283 found 792.4283
Anal Calcd for C40H61N3O13(H2O)0.6: C 59.85, H 7.81, N 5.23 Found C 59.85, H 7.67, N
5.32
IR(KBr): 3398, 2973, 2938, 2878, 2785, 1810, 1752, 1717, 1670, 1629, 1561, 1509, 1456,
1381, 1361, 1323, 1283, 1257, 1220, 1167, 1142, 1109, 1076, 1047, 1006, 992, 973, 953,
930, 914, 884, 856, 834, 770, 750, 693, 678, 622, 593, 554, 512, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.1, 14.3, 15.6, 15.7, 18.7, 19.9, 21.2, 22.3, 25.9, 28.2,
32.9, 38.1, 40.2, 42.2, 47.7, 49.5, 51.1, 65.9, 69.5, 70.3, 71.7, 76.2, 78.4, 78.8, 83.2, 84.7,
103.8, 111.9, 112.4, 119.2, 127.9, 143.5, 152.0, 154.0, 165.8, 166.2, 169.0, 204.0

I-235

MS(FAB):891+(M+H+). HRMS(FAB):calcd for C44H64N4O13Cl 891.4158 found 891.4164
Anal Calcd for C44H63N4O13Cl(H2O)1.2: C 57.88, H 7.22, N 6.14 Cl 3.88 Found C 57.92, H
7.00, N 5.94 Cl 3.88
IR(KBr): 3430, 2973, 2938, 2878, 2785, 1810, 1752, 1716, 1669, 1608, 1569, 1519, 1455,
1380, 1361, 1305, 1283, 1257, 1232, 1169, 1141, 1109, 1076, 1048, 1005, 992, 953, 931,
900, 835, 767, 732, 693, 642, 621, 512, 458, 403(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.7, 13.1, 14.2, 15.5, 15.7, 18.8, 19.8, 21.2, 22.4, 26.1,
28.2, 32.9, 38.2, 39.7, 40.2, 47.7, 49.6, 51.1, 65.9, 69.6, 70.4, 71.5, 76.3, 78.3, 79.2, 82.7,
84.5, 103.9, 112.6, 127.3, 127.8, 130.1, 131.6, 131.7, 133.9, 154.1, 158.7, 161.6, 165.5,
169.1, 172.8, 203.9

I-236

MS(FAB):942+(M+H+). HRMS(FAB):calcd for C47H64N3O15S 942.4059 found 942.4055
IR(KBr): 3423, 3068, 2973, 2938, 2878, 2785, 1809, 1751, 1716, 1672, 1590, 1571, 1522,
1456, 1381, 1360, 1314, 1258, 1228, 1170, 1157, 1109, 1075, 1048, 1005, 993, 952, 928,
898, 863, 835, 763, 751, 711, 679, 670, 621, 596, 541, 478, 414 (cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.1, 14.3, 15.5, 15.7, 18.7, 19.8, 21.2, 22.2, 26.1, 28.2,
32.9, 38.2, 40.2, 42.3, 47.6, 49.7, 51.0, 65.9, 69.5, 70.3, 71.6, 76.3, 78.4, 79.0, 82.9, 84.6,
103.8, 123.1, 123.5, 129.2, 129.8, 130.8, 131.6, 132.2, 133.1, 134.6, 140.5, 141.1, 141.2,
153.7, 165.4, 166.6, 169.1, 178.1, 203.9

I-237

MS(FAB):823+(M+H+). HRMS(FAB):calcd for C40H63N4O12S1 823.4163 found 823.4164
Anal Calcd for C40H62N4O12S(H2O)0.6: C 57.62, H 7.64, N 6.72 S 3.85 Found C 57.66, H
7.53, N 6.57 S 3.81
IR(KBr): 3412, 2972, 2937, 2878, 2784, 1810, 1751, 1716, 1662, 1577, 1556, 1517, 1455,
1391, 1360, 1301, 1257, 1233, 1166, 1140, 1109, 1076, 1048, 1005, 992, 953, 930, 834,
765, 693, 622, 529, 485, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.4, 13.1, 13.5, 14.3, 15.5, 15.6, 18.7, 19.9, 21.2, 22.3, 26.0,
28.2, 32.8, 38.2, 40.2, 42.1, 47.6, 49.8, 51.0, 65.9, 69.6, 70.3, 71.3, 76.3, 78.4, 78.8, 83.0,
84.4, 103.8, 118.4, 129.7, 135.5, 150.0, 153.6, 158.5, 166.0, 167.4, 169.0, 204.0

I-238

MS(FAB):877+(M+H+). HRMS(FAB):calcd for C47H65N4O12 877.4599 found 877.4603
Anal Calcd for C47H64N4O12(H2O)1.1: C 62.94, H 7.44, N 6.25 Found C 62.93, H 7.21, N
6.20
IR(KBr): 3430, 3060, 2973, 2937, 2877, 2784, 1810, 1751, 1716, 1664, 1517, 1455, 1380,
1361, 1322, 1288, 1257, 1232, 1166, 1110, 1076, 1047, 1004, 993, 952, 931, 865, 835,
798, 763, 692, 638, 599, 528, 433(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 13.0, 14.2, 15.5, 15.7, 18.7, 19.8, 21.2, 22.1, 26.0, 28.2,
32.8, 38.2, 40.2, 41.6, 47.7, 49.6, 51.0, 65.8, 69.5, 70.3, 72.0, 76.2, 78.4, 78.8, 82.7, 83.9,
103.8, 122.5, 125.3, 126.6, 129.6, 130.0, 141.1, 148.7, 152.5, 166.4, 167.5, 168.9, 204.1

I-239

MS(FAB):803+(M+H+). HRMS(FAB):calcd for C41H63N4O12 803.4442 found 803.4435
Anal Calcd for C41H62N4O12(H2O)0.8: C 60.25, H 7.84, N 6.85 Found C 60.29, H 7.63, N
6.47
IR(KBr): 3399, 2973, 2937, 2879, 2784, 1808, 1752, 1718, 1673, 1633, 1596, 1552, 1509,
1455, 1415, 1380, 1361, 1324, 1301, 1284, 1257, 1220, 1168, 1141, 1110, 1076, 1047,
1006, 991, 954, 933, 904, 815, 779, 755, 694, 622, 566, 512, 457, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.1, 14.2, 15.6, 15.8, 18.6, 19.9, 21.2, 22.3, 25.9, 28.2,
32.8, 38.1, 40.2, 42.5, 47.7, 49.6, 51.0, 65.8, 69.5, 70.3, 71.8, 76.1, 78.4, 78.8, 83.4, 85.0,
103.8, 122.9, 125.8, 138.4, 142.7, 150.2, 154.2, 165.3, 166.2, 169.1, 203.9

I-240

MS(FAB):859+(M+H+). HRMS(FAB):calcd for C39H63N4O13S2 859.3833 found 859.3846
Anal Calcd for C39H62N4O13S2(H2O)0.9: C 53.52, H 7.35, N 6.40 S 7.33 Found C 53.51,
H 7.20, N 6.36 S 7.21
IR(KBr): 3397, 2973, 2937, 2877, 2784, 1806, 1747, 1670, 1519, 1455, 1380, 1357, 1330,
1268, 1220, 1168, 1141, 1110, 1074, 1047, 1006, 991, 952, 931, 914, 835, 779, 755, 692,
624, 536, 497, 457, 420(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.1, 14.3, 15.6, 15.8, 18.7, 19.8, 21.2, 22.4, 25.9, 28.2,
32.5, 32.8, 35.3, 38.2, 40.2, 40.8, 42.0, 47.7, 49.6, 51.1, 65.9, 69.5, 70.3, 71.6, 76.3, 78.4,
78.9, 83.3, 84.7, 103.8, 153.9, 166.3, 169.1, 170.1, 173.7, 201.0, 203.9

I-241

MS(FAB):884+(M+H+). HRMS(FAB):calcd for C45H66N5O13 884.4657 found 884.4665
Anal Calcd for C45H65N5O13(H2O)1.7: C 59.09, H 7.54, N 7.66 Found C 59.05, H 7.37, N
7.57
IR(KBr): 3397, 3110, 2971, 2937, 2877, 2784, 1803, 1751, 1716, 1679, 1629, 1600, 1581,
1500, 1455, 1367, 1322, 1301, 1282, 1236, 1191, 1164, 1108, 1076, 1047, 1010, 993, 973,
954, 933, 904, 860, 781, 700, 673, 622, 601, 553, 511, 451, 433(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.2, 14.2, 15.6, 15.8, 18.7, 19.9, 21.2, 22.4, 25.9, 28.2,
32.8, 38.2, 40.2, 42.5, 47.7, 49.7, 51.1, 65.9, 69.6, 70.3, 72.0, 76.3, 78.5, 79.0, 83.7, 85.1,
103.8, 107.6, 109.0, 118.0, 121.7, 122.9, 123.1, 125.7, 134.5, 136.0, 136.2, 137.2, 154.5,
165.6, 166.4, 169.1, 203.9

I-242

MS(FAB):923+(M+H+). HRMS(FAB):calcd for C48H71N6O12 923.5130 found 923.5143
Anal Calcd for C48H70N6O12(H2O)0.5: C 61.85, H 7.68, N 9.02 Found C 61.88, H 7.52, N
9.00
IR(KBr): 3432, 3068, 2971, 2937, 2877, 1808, 1751, 1716, 1654, 1600, 1556, 1521, 1455,
1403, 1365, 1311, 1284, 1257, 1230, 1143, 1110, 1076, 1047, 1004, 993, 946, 898, 860,
823, 796, 767, 725, 694, 636, 622, 576, 549, 524, 451, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.4, 13.1, 14.2, 15.4, 15.8, 18.7, 19.7, 21.2, 22.4, 26.2, 28.2,
33.1, 38.2, 39.7, 40.2, 40.3, 47.7, 49.6, 51.1, 65.8, 69.4, 70.3, 71.7, 76.3, 78.4, 79.2, 82.8,
84.6, 103.7, 111.7, 115.9, 125.8, 129.3, 129.6, 131.2, 131.5, 143.4, 150.4, 153.2, 154.4,
165.0, 166.5, 169.0, 203.9

I-243

MS(FAB):881+(M+H+). HRMS(FAB):calcd for C43H66N4O13Cl 881.4315 found 881.4318
Anal Calcd for Anal Calcd for C43H65ClN4O13(H2O)0.7: C 57.77, H 7.49, N 6.27, Cl 3.97
Found C 57.76, H 7.37, N 6.24, Cl 3.96
IR(KBr): 3438, 2973, 2937, 2879, 2784, 1810, 1751, 1716, 1683, 1635, 1527, 1490, 1455,
1380, 1317, 1284, 1257, 1232, 1166, 1141, 1110, 1076, 1049, 1008, 993, 952, 931, 885,
831, 779, 755, 694, 622, 555, 514, 457(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 12.7, 13.1, 14.2, 15.5, 15.7, 18.7, 19.7, 21.1, 22.3, 26.1,
28.2, 32.9, 38.1, 39.2, 40.1, 47.6, 49.5, 51.0, 65.7, 69.4, 70.2, 71.5, 73.1, 76.1, 78.2, 79.0,
82.7, 84.5, 103.6, 127.2, 128.3, 134.0, 135.2, 153.9, 155.2, 165.0, 168.7, 169.4, 203.5

I-244

MS(FAB):934+(M+H+). HRMS(FAB):calcd for C50H68N3O14 934.4701 found 934.4698
Anal Calcd for C50H67N3O14(H2O)1.1: C 62.96, H 7.31, N 4.41 Found C 62.94, H 7.16, N
4.50
IR(KBr): 3446, 3062, 2973, 2937, 2877, 2784, 1812, 1751, 1716, 1668, 1641, 1575, 1525,
1477, 1455, 1438, 1388, 1373, 1324, 1301, 1284, 1232, 1166, 1139, 1110, 1076, 1047,
1004, 993, 952, 931, 916, 856, 833, 800, 765, 700, 622, 532, 474(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 11.6, 13.0, 14.2, 15.2, 15.5, 18.7, 19.7, 21.1, 22.1, 25.9,
28.1, 32.7, 38.0, 40.1, 41.8, 47.2, 49.3, 50.8, 65.7, 69.4, 70.1, 70.8, 76.0, 78.0, 78.3, 82.7,
84.1, 103.4, 117.4, 122.6, 124.1, 124.8, 127.9, 128.3, 128.8, 130.1, 132.9, 134.2, 152.8,
153.2, 160.1, 164.7, 165.4, 168.6, 178.0, 203.5

I-245

MS(FAB):919+(M+H+). HRMS(FAB):calcd for C45H71N6O12S 919.4851 found 919.4853
Anal Calcd for C45H70N6O12S(H2O)0.9: C 57.78, H 7.74, N 8.98, S 3.43 Found C 57.81, H
7.56, N 8.71, S 3.24
IR(KBr): 3390, 2971, 2937, 2877, 2784, 1814, 1752, 1716, 1656, 1567, 1506, 1455, 1380,
1361, 1305, 1282, 1234, 1166, 1110, 1076, 1049, 1004, 993, 952, 931, 914, 867, 835, 796,
777, 694, 676, 620, 582, 541, 512, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.1, 14.3, 15.6, 15.7, 18.8, 19.9, 21.2, 22.2, 23.3, 23.5,
26.1, 28.2, 32.9, 33.6, 38.2, 40.2, 41.3, 42.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 71.7, 76.3,
78.4, 79.0, 82.9, 84.3, 103.8, 116.7, 129.1, 138.4, 142.4, 149.3, 151.5, 153.4, 166.0, 167.5,
169.1, 204.0

I-246

MS(FAB):858+(M+H+). HRMS(FAB):calcd for C39H61N5O12ClS 858.3726 found 858.3737
IR(KBr): 3419, 2973, 2937, 2877, 2784, 1812, 1751, 1716, 1683, 1635, 1542, 1506, 1455,
1382, 1359, 1311, 1284, 1257, 1214, 1166, 1141, 1110, 1076, 1047, 1004, 993, 952, 931,
914, 902, 835, 800, 777, 746, 692, 669, 622, 553, 455, 422, 408(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.2, 14.5, 15.6, 18.8, 19.7, 21.1, 22.3, 26.0, 28.1,
33.0, 38.1, 40.1, 40.5, 47.6, 49.6, 51.0, 65.8, 69.4, 70.2, 71.5, 76.3, 78.2, 78.8, 82.7, 84.3,
103.6, 123.9, 153.4, 154.0, 158.8, 162.3, 165.6, 168.7, 169.7, 203.6

I-247

MS(FAB):914+(M+H+).HRMS(FAB):calcd for C47H65N3O13Cl 914.4206 found 914.4207
Anal Calcd for C47H64N3O13Cl(H2O)0.7: C 60.89, H 7.11, N 4.53, Cl 3.82 Found C 60.83,
H 7.03, N 4.58, Cl 3.80
IR(KBr): 3436, 2973, 2938, 2879, 2786, 1812, 1752, 1708, 1616, 1488, 1455, 1380, 1305,
1282, 1257, 1232, 1218, 1168, 1110, 1072, 1049, 1014, 993, 952, 931, 898, 860, 817, 765,
721, 698, 630, 601, 580, 507, 458, 430(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 10.4, 12.9, 13.1, 13.5, 14.1, 14.3, 15.3, 15.4, 15.8, 18.8,
19.7, 19.8, 21.1, 21.2, 22.2, 22.5, 26.3, 26.6, 28.1, 32.4, 38.2, 38.3, 38.5, 39.3, 40.2, 47.5,
47.7, 49.7, 49.8, 50.9, 51.1, 65.8, 69.5, 70.3, 70.9, 76.3, 76.4, 78.3, 79.3, 82.5, 82.8, 84.2,
84.7, 90.9, 91.4, 103.7, 103.8, 122.7, 122.8, 123.2, 123.5, 127.7, 127.8, 128.6, 128.8,
129.0, 129.3, 130.1, 130.3, 132.6, 132.7, 134.1, 134.3, 137.9, 138.1, 148.7, 149.4, 153.1,
154.0, 166.1, 166.4, 167.7, 167.8, 169.0, 203.9, 204.0

I-248

MS(FAB):866+(M+H+). HRMS(FAB):calcd for C43H68N3O13S 866.4473 found 866.4481
Anal Calcd for C43H67N3O13S(H2O)0.8: C 58.66, H 7.85, N 4.77, S 3.64 Found C 58.68, H
7.64, N 4.80, S 4.80
IR(KBr): 3390, 2973, 2937, 2877, 2784, 1808, 1751, 1716, 1671, 1600, 1587, 1498, 1455,
1382, 1361, 1303, 1286, 1240, 1168, 1110, 1076, 1047, 1006, 991, 952, 931, 900, 835,
800, 755, 692, 622, 555, 512, 455, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.3, 15.6, 15.7, 18.7, 19.9, 21.2, 22.4, 26.0, 28.2,
31.5, 32.9, 36.0, 38.2, 40.2, 41.7, 47.7, 49.7, 51.1, 65.9, 67.0, 69.5, 70.3, 71.7, 76.4, 78.4,
78.9, 83.2, 84.8, 103.8, 114.6, 120.8, 129.4, 154.0, 158.5, 166.0, 169.0, 169.8, 204.0

I-249

MS(FAB):792+(M+H+). HRMS(FAB):calcd for C39H62N5O12 792.4395 found 792.4395
Anal Calcd for C39H61N5O12(H2O)0.6: C 58.35, H 7.81, N 8.72 Found C 58.32, H 7.60, N
8.63
IR(KBr): 3407, 2973, 2937, 2879, 2784, 1810, 1751, 1716, 1679, 1581, 1525, 1475, 1455,
1380, 1361, 1324, 1301, 1282, 1232, 1220, 1168, 1141, 1110, 1076, 1047, 1031, 1004,
993, 952, 931, 900, 835, 800, 779, 755, 692, 622, 582, 526, 455, 408(cm-1)
13C-NMR(CDCl3):δ(ppm)10.4, 13.1, 14.2, 15.3, 15.6, 18.8, 19.7, 21.1, 21.7, 22.3, 22.4,
26.2, 28.2, 33.0, 38.1, 39.9, 40.1, 47.6, 49.5, 51.0, 65.7, 69.3, 70.2, 71.5, 76.2, 78.2, 78.9,
82.7, 84.4, 103.6, 141.6, 142.2, 142.8, 154.0, 156.5, 163.2, 165.2, 168.7, 203.6

I-250

MS(FAB):866+(M+H+). HRMS(FAB):calcd for C47H68N3O12 866.4803 found 866.4799
Anal Calcd for C47H67N3O12(H2O)0.9: C 63.98, H 7.86, N 4.76 Found C 63.99, H 7.56, N
4.78
IR(KBr): 3401, 3060, 3025, 2973, 2937, 2877, 2784, 1810, 1752, 1716, 1677, 1600, 1583,
1496, 1455, 1380, 1361, 1322, 1305, 1284, 1257, 1232, 1218, 1168, 1141, 1110, 1076,
1047, 1004, 991, 952, 931, 916, 835, 777, 746, 701, 632, 582, 553, 511, 476, 457,
431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.2, 15.6, 18.6, 19.7, 21.1, 22.4, 25.8, 28.2, 32.8,
38.1, 40.1, 41.8, 47.6, 49.4, 51.0, 57.2, 65.8, 69.3, 70.1, 71.8, 76.2, 78.2, 78.6, 83.1, 84..6,
103.5, 126.4, 126.5, 128.0, 128.1, 128.2, 128.7, 140.0, 140.1, 153.8, 165.6, 168.5, 171.7,
203.6

I-251

MS(FAB):909+(M+H+). HRMS(FAB):calcd for C47H65N4O12S 909.4320 found 909.4326
Anal Calcd for C47H64N4O12S(H2O)0.6: C 61.37, H 7.14, N 6.09, S 3.49 Found C 61.39, H
7.01, N 5.99, S 3.36
IR(KBr): 3421, 3060, 2973, 2937, 2877, 2784, 2223, 1810, 1751, 1716, 1660, 1585, 1509,
1457, 1380, 1361, 1322, 1301, 1284, 1257, 1232, 1166, 1141, 1110, 1076, 1047, 1006,
993, 952, 931, 835, 757, 694, 674, 622, 578, 557, 528, 458(cm-1)
13C-NMR(CDCl3):δ(ppm)10.4, 13.0, 14.2, 15.5, 15.7, 18.7, 19.8, 21.1, 22.2, 26.0, 28.2,
32.8, 38.1, 40.1, 41.8, 47.6, 49.6, 50.9, 65.7, 69.4, 70.2, 71.2, 76.1, 78.3, 78.8, 82.7, 84.2,
103.6, 113.9, 116.7, 126.7, 127.8, 128.2, 130.2 131.6, 132.1, 132.8, 133.2, 138.9, 141.1,
153.2, 165.5, 167.5, 168.8, 203.4

I-252

MS(FAB):873+(M+H+). HRMS(FAB):calcd for C44H65N4O14 873.4497 found 873.4504
Anal Calcd for C44H64N4O14(H2O)0.6: C 59.80, H 7.44, N 6.34 Found C 59.81, H 7.19, N
6.07
IR(KBr): 3421, 2973, 2938, 2879, 2784, 1810, 1751, 1718, 1685, 1521, 1455, 1384, 1328,
1303, 1284, 1257, 1234, 1168, 1110, 1076, 1047, 1004, 993, 952, 931, 914, 883, 835, 777,
723, 694, 622, 530, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 10.4, 13.1, 13.2, 14.2, 15.5, 15.6, 15.8, 18.7, 18.8, 19.8,
21.1, 22.3, 22.4, 26.0, 28.2, 32.9, 38.2, 40.1, 41.0, 47.6, 47.7, 49.5, 49.6, 49.8, 51.0, 51.1,
65.8, 69.4, 70.2, 71.5, 71.8, 76.2, 78.2, 78.3, 78.8, 79.0, 82.0, 83.0, 84.5, 103.6, 103.7,
123.1, 131.8, 133.6, 153.7, 153.8, 165.5, 165.7, 167.6, 168.6, 168.8, 169.3, 169.4, 203.5,
203.7

I-253

MS(FAB):879+(M+H+). HRMS(FAB):calcd for C43H67N4O13S 879.4425 found 879.4421
Anal Calcd for C43H66N4O13S(H2O)1.0: C 57.57, H 7.64, N 6.25, S 3.57 Found C 57.54, H
7.41, N 6.27, S 3.62
IR(KBr): 3424, 2973, 2937, 2879, 2784, 1808, 1751, 1679, 1515, 1490, 1455, 1380, 1284,
1234, 1166, 1141, 1110, 1076, 1047, 1006, 993, 952, 931, 852, 835, 800, 779, 750, 696,
620, 512, 455, 406(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 10.3, 13.0, 13.1, 14.2, 15.4, 15.6, 15.7, 18.6, 19.8, 21.1,
22.2, 25.8, 28.2, 32.7, 34.7, 34.8, 36.6, 36.8, 38.1, 40.1, 40.9, 42.2, 42.3, 47.5, 47.6, 49.4,
49.5, 50.9, 65.7, 69.4, 70.2, 71.6, 75.9, 76.0, 78.2, 78.3, 78.7, 78.8, 82.9, 83.0, 84.7, 84.8,
103.6, 103.7, 125.0, 125.1, 126.3, 126.4, 126.5, 126.6, 138.3, 138.4, 153.5, 153.6, 165.9,
166.0, 168.8, 169.0, 172.4, 172.5, 172.6, 172.7, 203.3, 203.4

I-254

MS(FAB):1059+(M+H+). HRMS(FAB):calcd for C40H61N4O13I2 1059.2325 found
1059.2317
IR(KBr): 3397, 3131, 3079, 2971, 2937, 2877, 2784, 1803, 1751, 1691, 1617, 1519, 1455,
1378, 1324, 1303, 1284, 1257, 1213, 1166, 1141, 1108, 1074, 1047, 1006, 993, 952, 931,
900, 835, 779, 754, 719, 694, 622, 586, 553, 455, 418, 404(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.0, 14.3, 15.6, 15.9, 18.6, 19.9, 21.2, 22.2, 26.0, 28.3,
32.8, 38.2, 40.2, 42.5, 47.7, 49.7, 51.0, 57.2, 65.8, 69.6, 70.3, 71.4, 76.1, 78.6, 79.0, 83.4,
85.5, 86.2, 103.9, 146.0, 154.4, 165.1, 166.7, 169.6, 170.9, 203.6

I-255

MS(FAB):908+(M+H+). HRMS(FAB):calcd for C48H82N3O13 908.5847 found 908.5853
Anal Calcd for C48H81N3O13(H2O)0.8: C 62.49, H 9.02, N 4.55 Found C 62.42, H 8.69, N
4.42
IR(KBr): 3401, 2937, 2867, 2784, 1812, 1752, 1704, 1671, 1509, 1455, 1380, 1361, 1322,
1303, 1284, 1257, 1234, 1166, 1141, 1110, 1076, 1047, 1004, 993, 952, 931, 914, 835,
777, 694, 622, 555, 528, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 10.2, 13.1, 14.3, 15.5, 15.7, 18.7, 19.8, 21.1, 21.8, 22.2,
22.3, 22.4, 23.4, 23.7, 23.8, 24.0, 25.7, 25.8, 26.0, 26.1, 26.7, 26.8, 28.2, 29.2, 29.3, 32.8,
33.7, 33.8, 37.0, 37.3, 38.1, 40.1, 41.7, 41.8, 47.5, 47.6, 49.4, 49.5, 51.0, 51.2, 51.3, 65.8,
69.4, 70.2, 71.7, 76.1, 78.2, 78.8, 82.9, 83.0, 84.5, 103.6, 153.5, 153.6, 165.5, 165.6, 168.8,
172.6, 172.7, 203.5, 203.6, 213.8, 213.9

I-256

MS(FAB):816+(M+H+). HRMS(FAB):calcd for C43H66N3O12 816.4647 found 816.4655
Anal Calcd for C43H66N3O13(H2O)0.85: C 62.13, H 8.09, N 5.05 Found C 62.43, H 7.80, N
4.75
IR(KBr): 3434, 3056, 2973, 2937, 2879, 2784, 1810, 1751, 1716, 1666, 1600, 1511, 1455,
1380, 1361, 1324, 1301, 1284, 1257, 1232, 1218, 1166, 1141, 1110, 1078, 1047, 1004,
993, 952, 931, 898, 835, 769, 754, 703, 634, 541, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.1, 14.2, 15.3, 15.5, 15.8, 18.8, 19.7, 21.2, 22.3,
26.1, 28.3, 30.3, 33.0, 38.0, 39.4, 40.1, 47.7, 49.5, 51.0, 65.7, 69.3, 70.2, 71.5, 76.2, 78.2,
79.0, 82.5, 84.5, 103.5, 127.6, 128.7, 130.7, 139.5, 154.0, 164.7, 168.7, 173.5, 203.5

I-257

MS(FAB):862+(M+H+). HRMS(FAB):calcd for C42H64N5O12S 862.4272 found 862.4278
Anal Calcd for C42H63N5O12S(H2O)0.8: C 57.56, H 7.43, N 7.99, S 3.66 Found C 57.64, H
7.29, N 7.79, S 3.56
IR(KBr): 3396, 3064, 2973, 2937, 2879, 2786, 1808, 1751, 1716, 1662, 1523, 1455, 1440,
1380, 1359, 1322, 1305, 1284, 1267, 1230, 1166, 1110, 1076, 1047, 1006, 991, 954, 931,
900, 835, 767, 744, 694, 620, 555, 528, 455, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.0, 14.3, 15.5, 15.7, 18.6, 19.8, 21.1, 22.3, 25.9, 28.2,
32.9, 34.9, 38.1, 40.1, 42.6, 47.6, 49.6, 50.9, 65.7, 69.4, 70.2, 71.2, 76.1, 78.3, 78.7, 83.1,
85.0, 103.6, 110.4, 118.2, 134.8, 143.7, 150.0, 153.9, 166.2, 168.8, 170.6, 203.5

I-258

MS(FAB):956+(M+H+). HRMS(FAB):calcd for C54H74N3O12 956.5272 found 956.5274
Anal Calcd for C54H73N3O12(H2O)0.7: C 66.95, H 7.74, N 4.34 Found C 66.98, H 7.51, N
4.33
IR(KBr): 3419, 3056, 2973, 2937, 2877, 2784, 1812, 1752, 1716, 1675, 1596, 1494, 1454,
1380, 1361, 1324, 1303, 1284, 1257, 1232, 1166, 1108, 1076, 1047, 1004, 991, 952, 931,
916, 835, 800, 752, 701, 613, 528, 455(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.1, 14.2, 15.6, 18.7, 18.9, 19.7, 21.1, 22.2, 25.8, 28.1,
32.7, 38.0, 40.1, 40.7, 47.2, 47.5, 49.5, 50.9, 56.1, 65.7, 69.4, 70.1, 71.5, 76.0, 78.2, 78.8,
82.8, 84.3, 103.6, 125.6, 127.4, 129.0, 129.1, 146.6, 153.5, 164.9, 168.7, 170.1, 203.5

I-259

MS(FAB):878+(M+H+). HRMS(FAB):calcd for C48H68N3O12 878.4803 found 878.4801
Anal Calcd for C48H87N3O12(H2O)0.9: C 64.47, H 7.75, N 4.70 Found C 64.29, H 7.46, N
4.51
IR(KBr): 3407, 3066, 2973, 2937, 2877, 2784, 1810, 1751, 1716, 1671, 1513, 1452, 1380,
1361, 1322, 1303, 1284, 1257, 1232, 1166, 1110, 1076, 1047, 1004, 993, 952, 931, 914,
863, 835, 761, 744, 692, 620, 580, 559, 528, 455, 426(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.2, 15.5, 15.6, 18.7, 19.8, 21.1, 22.2, 25.9, 28.2,
32.8, 38.1, 40.0, 40.1, 41.3, 43.9, 47.5, 49.5, 50.9, 65.8, 69.4, 70.2, 71.7, 76.1, 78.2, 78.8,
82.7, 84.2, 103.6, 119.4, 124.2, 124.4, 126.6, 126.7, 126.8, 140.5, 140.6, 146.6, 146.7,
153.2, 165.4, 168.6, 171.4, 203.5

I-260

MS(FAB):880+(M+H+). HRMS(FAB):calcd for C47H66N3O13 880.4596 found 880.4587
Anal Calcd for C47H85N3O13(H2O)1.0: C 62.86, H 7.52, N 4.68 Found C 62.85, H 7.25, N
4.38
IR(KBr): 3415, 3062, 2973, 2937, 2877, 2784, 1810, 1751, 1716, 1664, 1600, 1579, 1517,
1455, 1380, 1361, 1319, 1303, 1282, 1259, 1168, 1141, 1110, 1076, 1047, 993, 954, 931,
833, 798, 771, 755, 715, 696, 667, 640, 622, 528, 453(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.0, 14.2, 15.5, 15.6, 18.7, 19.8, 21.1, 22.3, 26.0, 28.2,
32.8, 38.1, 40.1, 42.3, 47.5, 49.5, 50.9, 65.8, 69.4, 70.2, 71.2, 76.1, 78.3, 78.7, 82.8, 84.4,
103.6, 128.1, 128.2, 129.1, 129.9, 130.7, 132.1, 132.2, 134.6, 137.3, 137.8, 153.5, 165.7,
167.2, 168.6, 195.8, 203.4

I-261

MS(FAB):854+(M+H+). HRMS(FAB):calcd for C42H62ClFN3O12 854.4006 found 854.4018
Anal Calcd for C42H81N3O12FCl(H2O)0.4: C 58.55, H 7.23, N 4.88 F 2.20 Cl 4.11 Found C
58.29, H 7.01, N 5.18 F 2.15 Cl 4.26
IR(KBr): 3390, 3081, 2973, 2937, 2877, 2784, 1812, 1752, 1716, 1671, 1627, 1600, 1562,
1509, 1455, 1380, 1361, 1324, 1284, 1249, 1234, 1216, 1201, 1168, 1141, 1110, 1076,
1047, 1006, 991, 954, 931, 914, 865, 835, 782, 748, 694, 622, 559, 511, 431(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.3, 15.5, 15.7, 18.6, 19.8, 21.1, 22.3, 25.9, 28.3,
32.9, 38.1, 40.1, 42.3, 47.5, 49.4, 51.0, 65.8, 69.4, 70.2, 71.2, 76.0, 78.3, 78.4, 82.9, 84.6,
103.6, 114.2, 114.5, 122.3, 122.5, 125.4, 125.5, 127.6, 127.8, 129.3, 129.4, 130.7, 135.7,
135.8, 153.5, 159.8, 163.2, 165.4, 165.6, 168.7, 203.6

I-262

MS(FAB):881+(M+H+). HRMS(FAB):calcd for C47H69N4O12 881.4912 found 881.4904
Anal Calcd for C47H68N4O12(H2O)0.5: C 63.42, H 7.81, N 6.29 Found C 63.39, H 7.70, N
6.18
IR(KBr): 3432, 3060, 2971, 2937, 2877, 2784, 1812, 1751, 1716, 1662, 1579, 1517, 1492, 1455, 1380, 1359, 1324, 1303, 1284, 1255, 1232, 1166, 1141, 1110, 1076, 1047, 1004, 993, 952, 931, 890, 833, 767, 682, 622, 528, 457(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.1, 14.2, 15.4, 15.6, 18.7, 19.8, 21.2, 22.2, 22.5, 22.8, 26.0, 26.4, 28.2, 32.8, 33.9, 38.2, 40.2, 41.2, 47.6, 49.6, 51.0, 65.9, 69.5, 70.3, 71.9, 76.3, 78.4, 78.8, 82.8, 84.1, 103.8, 123.5, 124.1, 126.3, 126.8, 128.5, 128.6, 141.1, 146.2, 152.9,
159.5, 166.3, 168.1, 168.9, 204.1

I-263

MS(FAB):876+(M+H+). HRMS(FAB):calcd for C48H66N3O12 876.4646 found 876.4645
Anal Calcd for C48H65N3O12(H2O)0.9: C 64.61, H 7.55, N 4.71 Found C 64.60, H 7.36, N
4.72
IR(KBr): 3438, 3054, 2973, 2937, 2877, 2784, 1810, 1751, 1716, 1660, 1560, 1508, 1455,
1380, 1361, 1322, 1303, 1286, 1255, 1232, 1166, 1141, 1110, 1076, 1047, 1004, 993, 952,
931, 889, 844, 792, 773, 734, 692, 632, 601, 555, 526, 435(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.1, 14.2, 15.3, 15.7, 18.7, 18.9, 19.7, 21.2, 22.2, 26.0,
28.2, 32.9, 38.2, 40.2, 41.0, 47.7, 49.6, 51.1, 65.8, 69.5, 69.7, 70.3, 71.9, 76.3, 78.3, 78.9,
82.7, 84.1, 103.7, 125.1, 125.2, 126.5, 128.1, 128.2, 128.4, 131.2, 132.0, 153.2, 165.9,
168.9, 169.8, 204.1

I-264

MS(FAB):856+(M+H+). HRMS(FAB):calcd for C41H63ClN3O12S 856.3821 found 856.3814
Anal Calcd for C41H62N3O12ClS(H2O)0.4: C 57.02, H 7.33, N 4.87 Cl 4.10 S 3.71 Found C
56.99, H 7.20, N 4.93 Cl 4.10 S 3.79
IR(KBr): 3392, 2973, 2937, 2877, 2784, 1808, 1751, 1716, 1675, 1515, 1477, 1455, 1382,
1361, 1322, 1303, 1284, 1257, 1234, 1166, 1110, 1095, 1076, 1047, 1008, 991, 954, 931,
900, 817, 777, 755, 744, 694, 622, 538, 489, 439, 420, 408(cm-1)
13C-NMR(CDCl3):δ(ppm)10.3, 13.1, 14.2, 15.6, 18.6, 19.8, 21.1, 22.3, 25.9, 28.1, 32.8,
37.5, 38.0, 40.1, 41.7, 47.6, 49.5, 50.9, 65.7, 69.4, 70.1, 71.6, 76.2, 78.2, 78.7, 83.0, 84.6,
103.5, 128.7, 129.9, 131.8, 134.0, 153.7, 165.7, 168.2, 168.7, 203.6

I-265

MS(FAB):868+(M+H+). HRMS(FAB):calcd for C42H66N3O14S 868.4265 found 868.4270
Anal Calcd for C42H65N3O14S(H2O)0.8: C 57.16, H 7.61, N 4.76 S 3.63 Found C 57.12, H
7.43, N 4.75, S 3.63
IR(KBr): 3390, 3064, 2973, 2937, 2879, 2784, 1810, 1751, 1716, 1675, 1585, 1515, 1455,
1380, 1363, 1309, 1286, 1257, 1234, 1155, 1110, 1074, 1047, 1006, 993, 952, 931, 912,
835, 771, 754, 734, 690, 622, 576, 547, 532, 431, 418(cm-1)
13C-NMR(CDCl3):δ(ppm)9.96, 13.0, 14.3, 15.4, 15.7, 18.6, 19.8, 21.1, 22.1, 25.8, 28.1,
29.0, 32.8, 38.0, 40.1, 42.4, 47.4, 49.4, 50.9, 52.1, 65.7, 69.4, 70.2, 70.9, 76.0, 78.2, 78.6,
82.9, 84.7, 103.6, 128.2, 128.9, 133.3, 138.6, 153.5, 165.8, 168.9, 169.0, 203.7

I-266

MS(FAB):833+(M+H+). HRMS(FAB):calcd for C42H62FN4O12 833.4348 found 833.4373
Anal Calcd for C42H61N4O12F(H2O)0.7: C 59.66, H 7.44, N 6.63 F 2.25 Found C 59.69, H
7.35, N 6.64 F 2.15
IR(KBr): 3411, 2973, 2938, 2879, 2786, 1810, 1751, 1716, 1646, 1548, 1506, 1482, 1454,
1423, 1380, 1324, 1303, 1282, 1257, 1230, 1164, 1110, 1076, 1047, 1004, 991, 954, 933,
916, 856, 835, 800, 767, 734, 692, 619, 601, 528, 511, 478, 457, 433, 403(cm-1)
13C-NMR(CDCl3):δ(ppm)10.1, 13.1, 14.2, 15.6, 18.7, 19.8, 21.1, 22.3, 26.1, 28.1, 32.8,
38.1, 40.1, 41.5, 47.6, 49.6, 51.0, 65.7, 69.4, 70.2, 71.2, 76.2, 78.3, 78.9, 83.0, 84.6, 103.2,
103.3, 103.6, 106.1, 106.4, 112.6, 112.7, 112.9, 127.7, 127.8, 132.0, 133.0, 154.0, 156.1,
159.2, 161.7, 165.9, 168.7, 203.6

I-267

MS(FAB):841+(M+H+). HRMS(FAB):calcd for C44H65N4O12 841.4599 found 841.4600
Anal Calcd for C44H64N4O12(H2O)0.4: C 61.91, H 7.72, N 6.56 Found C 61.86, H 7.68, N
6.41
IR(KBr): 3403, 3058, 2973, 2937, 2877, 2784, 1808, 1751, 1716, 1656, 1614, 1577, 1506,
1455, 1380, 1361, 1328, 1305, 1280, 1251, 1234, 1166, 1139, 1110, 1074, 1047, 1006,
991, 954, 931, 914, 833, 800, 769, 744, 692, 624, 593, 553, 514, 470, 455, 424(cm-1)
13C-NMR(CDCl3):δ(ppm)10.0, 13.1, 14.2, 15.7, 15.8, 18.5, 19.8, 21.1, 22.1, 25.8, 28.1,
32.8, 38.0, 40.1, 41.9, 47.6, 49.4, 50.9, 65.6, 69.3, 70.2, 71.7, 76.0, 78.2, 78.7, 83.2, 84.7,
103.5, 111.4, 112.9, 115.3, 119.6, 120.3, 122.1, 125.8, 127.4, 133.9, 136.6, 154.0, 165.3,
167.4, 168.6, 203.7

VI ( 19 )
I-268

MS(FAB):812+(M+H+). HRMS(FAB):calcd for C39H62N3O13S 812.4003 found 812.4001
IR(CHCl3):3020, 3016, 2978, 2934, 1806, 1730, 1455, 1374, 1247, 1229, 1162, 1108,
1070, 1044, 990, 908(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.9, 14.0, 15.3, 15.4, 18.5, 19.6, 21.0, 22.1, 25.8, 28.0,
32.7, 37.9, 40.0, 44.5, 47.4, 49.2, 50.8, 65.5, 69.3, 70.1, 71.0, 76.2, 78.0, 78.6, 82.7, 84.3,
103.5, 126.7, 128.8, 132.2, 140.1, 153.5, 166.2, 168.8, 203.9

I-269

MS(FAB):840+(M+H+). HRMS(FAB):calcd for C41H66N3O13S1 840.4316 found 840.4316
IR(CHCl3):3020, 2970, 2934, 2872, 1804, 1752, 1714, 1454, 1381, 1361, 1323, 1281,
1232, 1229, 1161, 1108, 1071, 1046, 1006, 988, 952(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.2, 15.5, 18.6, 19.7, 21.1, 22.2, 25.9, 28.1, 29.8,
32.9, 38.1, 40.1, 44.2, 47.5, 49.6, 50.9, 54.2, 65.7, 69.4, 70.2, 76.3, 78.2, 78.8, 82.8, 84.5,
103.6, 126.5, 128.3, 128.6, 138.2, 153.7, 166.1, 168.9, 203.9

I-270

MS(FAB):826+(M+H+). HRMS(FAB):calcd for C40H64N3O13S1 826.4160 found 826.4150
IR(CHCl3):3341, 3025, 3019, 3015, 2977, 2939, 2880, 2838, 2788, 1804, 1752, 1717,
1602, 1495, 1455, 1407, 1382, 1362, 1328, 1282, 1258, 1225, 1221, 1211, 1162, 1109,
1072, 1048, 1007, 989, 952, 931, 914, 889, 833(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 13.0, 14.2, 15.6, 18.6, 18.7, 19.7, 21.1, 22.2, 22.3, 25.9,
28.1, 33.0, 38.1, 40.1, 44.7, 47.6, 49.6, 51.0, 59.3, 65.7, 69.4, 70.2, 72.3, 76.2, 78.2, 78.8,
82.8, 84.6, 103.6, 128.2, 128.4, 128.6, 128.9, 129.7, 130.7, 130.8, 153.9, 165.9, 168.9,
203.9

I-271

MS(FAB):854+(M+H+). HRMS(FAB):calcd for C41H64N3O12S2 854.3931 found 854.3923
IR(CHCl3):3032, 2977, 2938, 1754, 1717, 1455, 1381, 1357, 1326, 1298, 1205, 1164,
1148, 1106, 1072, 1052, 989, 972, 950, 914, 862, 825(cm-1)
13C-NMR(CDCl3):δ(ppm)10.2, 12.7, 14.3, 15.5, 15.9, 18.8, 19.8, 21.2, 22.4, 26.2, 28.3,
33.6, 38.2, 40.2, 44.0, 47.6, 49.8, 51.0, 65.9, 69.4, 70.2, 71.8, 75.8, 78.4, 78.8, 88.0, 89.4,
103.7, 125.8, 128.3, 128.9, 130.5, 132.8, 140.8, 166.0, 168.9, 190.5, 203.9

VII ( 20 )
I-272

MS(FAB):701+(M+H+).HRMS(FAB):calcd for C34H57N2O13 701.3861 found 701.3862
IR(KBr):3439, 2975, 2937, 2879, 1804, 1752, 1717, 1593, 1457, 1409, 1382, 1363, 1314,
1283, 1238, 1165, 1142, 1111, 1082, 1049, 1005, 953, 900, 779, 691, 632, 573, 532, 512,
454, 408(cm-1)
13C-NMR(CD3OD):δ(ppm)10.9, 13.4, 14.7, 15.8, 16.3, 18.8, 19.1, 20.9, 21.3, 23.5, 27.6,
31.6, 39.3, 40.1, 50.3, 52.2, 66.8, 69.4, 70.6, 77.6, 79.9, 80.3, 81.0, 84.4, 86.5, 104.2,
156.1, 165.8, 171.0, 180.1, 206.0

6Bd

MS(FAB):983+(M+H+). HRMS(FAB):calcd for C52H75N2O16 983.5117 found 983.5123
Anal Calcd for C52H74N2O16 :C 63.53, H 7.59, N 2.85 Found C 63.35, H 7.58, N 3.07
IR(KBr): 3448, 3066, 3033, 2976, 2938, 2878, 1749, 1705, 1629, 1497, 1455, 1406, 1381,
1334, 1293, 1254, 1172, 1115, 1085, 1067, 1033, 984, 959, 936, 916, 783, 767, 754, 739,
698, 614, 521, 472(cm-1)

6Bf

MS(FAB):997+(M+H+). HRMS(FAB):calcd for C53H77N2O16 997.5273 found 997.5278
IR(KBr): 3438, 3066, 3033, 2974, 2938, 2877, 1749, 1706, 1629, 1497, 1455, 1406, 1381,
1333, 1254, 1172, 1115, 1068, 1033, 985, 960, 935, 918, 783, 767, 754, 698, 473(cm-1)

6Ad

MS(FAB):1009+(M+H+). HRMS(FAB):calcd for C53H73N2O17 1009.4909 found
1009.4918
Anal Calcd for C53H72N2O17(H2O)0.4(CHCl3)0.13 :C 61.84, H 7.12, N 2.71, Cl 1.34 Found C
61.81, H 7.12, N 2.96, Cl 1.33
IR(KBr): 3424, 3065, 3032, 2975, 2938, 2880, 1811, 1752, 1704, 1497, 1455, 1382, 1330,
1292, 1254, 1167, 1114, 1084, 1066, 989, 953, 933, 909, 782, 768, 754, 698(cm-1)

6Af

MS(FAB):1023+(M+H+). HRMS(FAB):calcd for C54H75N2O17 1023.5066 found
1023.5050
IR(KBr): 3431, 3066, 3033, 2974, 2938, 2879, 1811, 1752, 1704, 1632, 1497, 1456, 1382,
1330, 1291, 1254, 1167, 1114, 1067, 991, 932, 912, 782, 768, 754, 698, 457(cm-1)

試験例１
化合物（Ｉ）の抗菌活性について調べた。
（試験方法）
最小発育阻止濃度（ＭＩＣ：μg/ml）の測定は日本化学療法学会標準法に準じ、接種菌
量は1000 cfu/spot、試験培地は感受性ディスク培地を用いて、寒天平板希釈法により実施した。

本発明化合物は、エリスロマイシン耐性菌（ＥＭ−Ｒ）を含む黄色ブドウ球菌や肺炎球
菌またはインフルエンザ菌に対して、市販のエリスロマイシン誘導体と同等レベルまたは
それ以上の抗菌活性を示した。

試験例２
抗菌活性と９位イミノエーテル型側鎖の長さやカルバモイル基等の関係について、試験
例１と同様の方法で調べた。

9位イミノエーテル型側鎖部分において、スペーサー部分にカルバモイル基等が存在す
る方がインフルエンザ菌等に対する抗菌活性が増強されることが分かった。また、Ｘが−
ＮＨＣＯ−である場合、隣接するアルキレン部分の長さは、好ましくは炭素数（ｎ）が３
〜５、より好ましくは３であることが分かった。

試験例３
化合物（Ｉ）の体内動態として、ラットでの肺移行性を調べた。
（試験方法）
化合物をラットに経口投与し、1、3、6時間後にエーテル麻酔下、心臓採血後肺を摘出し
た。肺1 gあたり4 mLの0.1 mol/L phosphate buffer, pH8/MeOH(1:4) δ 0.1%Tween80
を加えてホモジネートし、遠心分離して得られた上清を組織試料とした。組織試料中薬物
濃度の定量はMicrococcus luteus ATCC9341を検定菌とする微生物学的定量法を用いた。

本発明化合物は、肺内の移行性が優れているクラリスロマイシンと同等またはそれ以上
の肺移行性を示した。 (Abbreviation) Me: methyl; Et: ethyl; HOBt: 1-hydroxybenzotriazole P
h: phenyl; Ac: acetyl; Cbz: carbobenzoxy; THF: tetrahydroph
Run; DMSO: Dimethylsulfoxide; DMF: Dimethylformamide; TMSI: Trimethylsilane; WSCD: Water-soluble carbodiimide; 1-Ethyl-3- (3-dimethylaminopropyl) -carbodiimide) Ms: Methanesulfonyl

Example 1

At room temperature, compound 1 (60 g) is dissolved in 250 ml of THF, and 4.8 ml of conc. HCl is added dropwise thereto.
After stirring the reaction solution at room temperature for 1.5 hours, AcOEt extraction was performed by adding a saturated aqueous NaHCO3 solution.
It was. The extract was washed with brine, dried over anhydrous MgSO4, and concentrated under reduced pressure. Obtained by concentrating
The resulting oily substance was subjected to silica gel column chromatography (hexane-ethyl acetate system)
After separation and purification at, the solvent was distilled off under reduced pressure to obtain white foam compound 2 (53.1 g).
MS (FAB): 899+ (M + H +). HRMS (FAB): calcd for C48H71N2O14 899.4905 found 899.4902
Anal Calcd for C48H70N2O14 (H2O) 0.5: C 63.49, H 7.88, N 3.08 Found C 63.47, H 7.90, N
3.07
IR (KBr): 3503, 3066, 3033, 2976, 2938, 2878, 2831, 1752, 1732, 1706, 1629, 1497, 1455,
1406, 1380, 1334, 1292, 1255, 1165, 1120, 1076, 1002, 983, 957, 935, 895, 783, 768, 754,
699, 665, 595, 577, 517, 472 (cm-1)
Under a nitrogen atmosphere, a solution of 16.8 ml of DMSO added to 260 ml of dichloromethane was cooled to -78 ° C,
16.8 ml of (CF3CO) 2O was added dropwise and stirred for 15 minutes at -78 ° C. Compound 2 (53.1g) was added to this.
A solution dissolved in 230 ml of dichloromethane was added dropwise over 15 minutes, and the mixture was stirred at -78 ° C for 1.5 hours.
To this reaction solution, 41.2 ml of triethylamine was added dropwise at −78 ° C., and the mixture was further stirred for 2 hours, and then saturated NH 4 Cl
Aqueous solution was added to extract CHCl3. The extract was dried over anhydrous MgSO4 and concentrated under reduced pressure.
The oily substance obtained by this concentration was subjected to silica gel column chromatography (hexane
Separation and purification over ethyl acetate), the solvent was distilled off under reduced pressure, and white foam compound 3B (44.7 g)
Got.
MS (FAB): 897+ (M + H +). HRMS (FAB): calcd for C48H69N2O14 897.4749 found 897.4742
Anal Calcd for C48H68N2O14 (H2O) 0.3: C 63.88, H 7.66, N 3.10 Found C 63.84, H 7.61, N
3.03
IR (KBr): 3513, 3417, 3066, 3033, 2977, 2938, 2877, 1748, 1705, 1497, 1455, 1406, 1380,
1333, 1292, 1254, 1169, 1115, 1069, 984, 935, 917, 892, 783, 767, 754, 738, 698, 594,
473 (cm-1)

Example 2

Under a nitrogen atmosphere, 16.1 ml of pyridine was added to a solution of compound 3B (34.8 g) in 420 ml of THF.
Then, the mixture was cooled and stirred under ice cooling. (CCl3O) 2CO (15 g) was aliquoted into this solution under ice cooling.
I added it. After the addition is complete, stir for 15 minutes under ice cooling, then raise to room temperature and stir overnight at room temperature.
It was. Saturated aqueous NaHCO 3 solution was carefully added to the reaction solution, and extracted with AcOEt. The extract is anhydrous
After drying with MgSO4, the mixture was concentrated under reduced pressure. The oily substance obtained by this concentration is converted to silica gel.
Separation and purification by column chromatography (hexane-ethyl acetate system) to reduce solvent
Distillation under pressure gave white foam compound 3A (18.9 g).
MS (FAB): 923+ (M + H +). HRMS (FAB): calcd for C49H67N2O15 923.4541 found 923.4545
Anal Calcd for C48H68N2O14 (H2O) 0.3: C 63.14, H 7.25, N 3.01 Found C 63.10, H 7.22, N
2.98
IR (KBr): 3428, 3066, 3032, 2976, 2938, 2880, 1811, 1752, 1704, 1644, 1497, 1455, 1382,
1330, 1292, 1254, 1167, 1114, 1067, 990, 953, 931, 913, 782, 769, 754, 739, 698, 613,
596, 519, 457 (cm-1)

Compound 3A (1.5 g) was dissolved in a mixed solution of 10 ml of dichloromethane and 2 ml of methanol, and the temperature was -78 ° C.
After cooling, ozone gas was bubbled for 2 hours, and nitrogen gas was bubbled for 5 minutes.
To this reaction solution, 0.6 ml of dimethyl sulfide was added at −78 ° C. and stirred.
20 ml was added and extracted with CHCl3. The extract was then dried over anhydrous MgSO4 and concentrated under reduced pressure.
did. Add t-BuOH 15ml, H2O 5ml, 2-Methyl-2-butene 0.8ml to the concentrate and stir at room temperature
To do. To this solution, 254 mg of NaH2PO4 ・ 2H2O and 643 mg of NaClO2 were added at room temperature and stirred for 1 hour.
After stirring and cooling under ice cooling, 15 ml of 1N HCl was added to extract CHCl3. Extract the anhydrous MgSO4
And dried under reduced pressure, followed by concentration under reduced pressure, followed by silica gel column chromatography (CHCl3-
Methanol)), the solvent is distilled off under reduced pressure, and white foam compound 4Aa (1.03 g)
Got.
MS (FAB): 963+ (M + Na +). HRMS (FAB): calcd for C48H64N2O17Na1 963.4103 found
963.4106
Anal Calcd for C48H64N2O17 (H2O) 2: C 59.01, H 7.01, N 2.87 Found C 58.95, H 6.76, N
2.93
IR (KBr): 3430, 3065, 3032, 2975, 2938, 2881, 1809, 1752, 1703, 1618, 1497, 1455, 1406,
1382, 1329, 1290, 1253, 1167, 1113, 1082, 1067, 992, 954, 933, 895, 826, 782, 770, 754,
698, 622, 595, 573, 518, 458 (cm-1)

Example 3

In a nitrogen atmosphere, compound 3B (12.6 g) was dissolved in a mixed solution of EtOH 400 ml and THF 40 ml.
Stir at room temperature. To this was added 160 mg of Pd (OAc) 2, and after complete dissolution using ultrasound, PPh3
Add 560mg, HCO2H 1.6ml, NEt3 5.8ml sequentially. Increase the temperature of the reaction solution to heat to reflux
Under stirring for 2 hours, cool to room temperature again. After evaporating the solvent under reduced pressure, saturated NH4Cl aqueous solution
The solution was added and extracted with AcOEt. The extract was dried over anhydrous MgSO4 and concentrated under reduced pressure.
The oily substance obtained by this concentration was subjected to silica gel column chromatography (hexane
Separation and purification over ethyl acetate), the solvent was distilled off under reduced pressure, and white foam compound 5B (11.2 g)
Got.
MS (FAB): 857+ (M + H +). HRMS (FAB): calcd for C45H65N2O14 857.4436 found 857.4438
Anal Calcd for C45H64N2O14 (H2O) 0.4: C 62.54, H 7.56, N 3.24 Found C 62.49, H 7.47, N
3.17
IR (KBr): 3421, 3065, 3033, 2976, 2938, 2877, 1748, 1706, 1640, 1587, 1497, 1455, 1406,
1381, 1333, 1292, 1253, 1168, 1114, 1086, 1069, 1034, 983, 957, 936, 918, 892, 825, 783,
768, 754, 739, 698, 657, 614, 518, 472 (cm-1)

In a nitrogen atmosphere, a solution of compound 5B (6.39 g) dissolved in 640 ml of DMF was stirred and placed under ice cooling.
Add 7.46 g of 60% NaH in small portions. After stirring for 1 hour under ice cooling, (R) -2-Bromo-propionic
3.6 g of acid allyl ester was added dropwise, and the mixture was further stirred for 30 minutes under ice cooling. This reaction solution was cooled with ice and 1N
-Add 120 ml of HCl to extract AcOEt, wash the extract with brine, and dry with anhydrous MgSO4.
Dried. The solvent was then distilled off under reduced pressure, followed by silica gel column chromatography (hexa
-Ethyl acetate), and the solvent was distilled off under reduced pressure to obtain white foam compound 6Bb (5.53
g) was obtained.
MS (FAB): 969+ (M + H +). HRMS (FAB): calcd for C51H73N2O16 969.4960 found 969.4968
Anal Calcd for C51H72N2O16: C 63.21, H 7.49, N 2.89 Found C 63.08, H 7.52, N 3.09
IR (KBr): 3451, 3066, 3033, 2979, 2938, 2877, 1749, 1705, 1648, 1630, 1497, 1455, 1406,
1380, 1333, 1255, 1169, 1149, 1116, 1085, 1068, 983, 958, 911, 895, 783, 767, 754, 698,
614, 521, 472 (cm-1)

Example 4

Under a nitrogen atmosphere, a solution of 6Bb (2.05 g) in 100 ml of THF was cooled under ice-cooling, and (CCl3) 2CO
After adding 1.24 g, add 1.7 ml of Pyridine dropwise. After dropping, stir for 30 minutes under ice cooling, then
And stirred at room temperature for 4 hours. The reaction solution is cooled again under ice-cooling, and saturated aqueous NaHCO3 solution is poured.
In addition, AcOEt was extracted. The extract was dried over anhydrous MgSO4 and concentrated under reduced pressure.
After concentration, separation by silica gel column chromatography (hexane-ethyl acetate system)
After purification, the solvent was distilled off under reduced pressure to obtain white foam compound 6Ab (1.95 g).
MS (FAB): 995+ (M + H +). HRMS (FAB): calcd for C52H71N2O17 995.4753 found 995.4742
Anal Calcd for C51H72N2O16 (H2O) 0.3 (CHCl3) 0.08: C 61.93, H 7.05, N 2.77, Cl 0.84 Found C
61.91, H 6.99, N 3.00, Cl 0.82
IR (KBr): 3428, 3065, 3032, 2977, 2938, 2880, 1812, 1752, 1704, 1647, 1497, 1455, 1382,
1329, 1289, 1254, 1167, 1115, 1084, 1067, 1047, 989, 952, 897, 782, 769, 754, 698, 623,
518, 472 (cm-1)

Under a nitrogen atmosphere, AcOEt 30 ml was added to a solution of 6Ab (1.95 g) dissolved in CH3CN 30 ml and ice-cooled.
Cool down and add Pd (PPh3) 4 229mg, PPh3 104mg, pyrolidine 248μl, H2O 3ml sequentially,
The mixture was stirred at room temperature for 2 hours. AcOEt was extracted by adding 100 ml of 10% H3PO4. Extract
After washing with brine, drying over anhydrous MgSO4, and then distilling off the solvent under reduced pressure,
Separation and purification by column chromatography (chloroform-methanol system), solvent
Was distilled off under reduced pressure to obtain white foam compound 4Ab (1.14 g).
MS (FAB): 955+ (M + H +). HRMS (FAB): calcd for C49H67N2O17 955.4440 found 955.4450
Anal Calcd for C49H66N2O17 (H2O) 0.6: C 60.93, H 7.01, N 2.90 Found C 60.96, H 6.82, N
2.91
IR (KBr): 3423, 3065, 3033, 2978, 2939, 2881, 1813, 1752, 1704, 1497, 1455, 1382, 1330,
1291, 1254, 1167, 1114, 1084, 1066, 1048, 991, 951, 897, 826, 782, 770, 754, 739, 698,
624, 519, 457 (cm-1)

Example 5

DMF 2μl, (ClCO) 2 58.5 in a solution of 4Aa (300mg) dissolved in 6ml of toluene under nitrogen atmosphere
μl was added and stirred at room temperature for 2 hours. Add 181 μl of 3-Phenyl-propylamine to this
The mixture was stirred at room temperature for 15 minutes. Add saturated NH4Cl aqueous solution, extract AcOEt, and wash the extract with brine
After purification, it was dried using anhydrous MgSO4. Next, after removing the solvent under reduced pressure,
Separation and purification by ram chromatography (hexane-ethyl acetate system), and the solvent under reduced pressure
Distillation gave white foam compound 7Aa-1 (298 mg).
7Aa-1 (298mg) is dissolved in EtOH 24ml, Pd (OH) 2 / C 89mg, Acetate Buffer (0.2mol / l, pH
4.4) 6 ml was added and hydrogenated with stirring under normal pressure for 1 hour. to this
Add 2.1 ml of HCHOaq (37%), add hydrogen while stirring for another 2 hours, and filter to reduce the filtrate.
Concentrated under pressure. Saturated NaHCO3 aqueous solution was added to the concentrated solution and extracted with AcOEt.
After drying with MgSO4, the mixture was concentrated under reduced pressure. After concentration, silica gel column chromatography
(Chloroform-methanol system) Separation and purification, the solvent is distilled off under reduced pressure to form white foam
Compound 9Aa-1 (178 mg) was obtained.
MS (FAB): 804+ (M + H +). HRMS (FAB): calcd for C42H66N3O12 804.4647 found 804.4650
IR (KBr): 3433, 3061, 2973, 2936, 2878, 2785, 1809, 1751, 1716, 1671, 1536, 1495, 1455,
1380, 1321, 1284, 1259, 1232, 1166, 1110, 1078, 1048, 994, 954, 932, 892, 775, 750, 700,
628, 559, 532, 455 (cm-1)
1H-NMR (CDCl3) δ (ppm): 0.89 (3H, t, J = 7.2 Hz), 1.01 (3H, d, J = 6.9 Hz), 1.24 (3H, d, J =
6.3 Hz), 1.26 (3H, d, J = 6.9 Hz), 1.27 (3H, d, J = 7.5 Hz), 1.37 (3H, d, J = 6.9 Hz), 1.38 (3H,
s), 1.56 (3H, s), 1.54-1.94 (8H, m), 2.31 (6H, s), 2.55 (2H, m), 2.66 (2H, t, J = 8.1 Hz),
2.69 (3H, s), 3.02 (1H, quintet, J = 7.5 Hz), 3.16-3.28 (2H, m), 3.32-3.46 (1H, m), 3.48-
3.74 (2H, m), 3.83 (1H, q, J = 6.9 Hz), 4.22 (1H, d, J = 7.5 Hz), 4.31 (1H, d, J = 7.2 Hz),
4.45 (2H, s), 4.82 (1H, s), 5.00 (1H, dd, J = 2.4 and 9.9 Hz), 6.90 (1H, brt, J = 5.4 Hz),
7.12-7.30 (5H, m)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 14.3, 15.4, 15.6, 18.8, 19.9, 21.1, 22.3, 26.3, 28.5,
30.9, 33.1, 38.0, 38.8, 40.1, 47.6, 49.8, 51.0, 65.9, 69.3, 70.2, 73.0, 76.1, 78.4, 78.6, 82.3,
84.5, 103.6, 125.7, 128.3, 128.4, 141.5, 153.8, 167.5, 169.2, 170.3, 203.9

Example 6

DMF 16μl, (ClCO) 2 220 in a solution of 4Ab (2.0g) dissolved in 42ml of toluene under nitrogen atmosphere
μl was added and stirred at room temperature for 3.5 hours. Add 1.56 g of 3-Quinoxalin-6-yl-propylamine to this
A solution dissolved in 5 ml of MF was added and further stirred at room temperature for 20 minutes. Add saturated NH4Cl aqueous solution
AcOEt was extracted, and the extract was washed with brine and dried using anhydrous MgSO4. Then decompression
After distilling off the solvent, silica gel column chromatography (hexane-ethyl acetate-
Acetonitrile)), the solvent is distilled off under reduced pressure, and white foam compound 7Ab-2
(1.97 g) was obtained.
Under a nitrogen atmosphere, a solution of 7Ab-2 (1.96g) dissolved in 17ml of CH2Cl2 was cooled under ice cooling, and TMSI
1.24 ml was added and stirred for 20 minutes under ice cooling. Add AlCl3 (1.16g), anisole 11ml to CH2Cl2
A solution dissolved in 11 ml was further added and stirred for 1 hour under ice-cooling. H2O under ice-cooled reaction
Carefully add 1.74 ml and a precipitate will form. Add 35 ml of hexane and decant
Shon. Remove the supernatant, add 35 ml of hexane, and decant. Supernatant
After removing the liquid, CHCl3 120 ml, MeOH 30 ml, and saturated NaHCO3 aqueous solution were added to the precipitate to add CHCl3
The extract was dried over anhydrous MgSO4 and concentrated under reduced pressure. After concentration, MeOH 17ml, 98%
Add 0.9 ml of HCOOH (134 μl) and HCHOaq (37%) and stir for 1.5 hours in a 75 ° C oil bath.
Stir. Cool to room temperature, add saturated aqueous NaHCO3, extract with AcOEt, and wash the extract with brine.
After purification, it was dried using anhydrous MgSO4. Next, after removing the solvent under reduced pressure,
Separation and purification by ram chromatography (chloroform-methanol system) to reduce solvent
Distillation under pressure gave white foam compound 9Ab-2 (1.51 g).
Anal Calcd for C45H67N5O12: C 62.12, H7.76, N8.05 Found C 61.79, H7.72, N7.94
MS (FAB): 870+ (M + H +). HRMS (FAB): calcd for C45H68N5O12 870.4864 found 870.4873
IR (KBr): 3435, 2974, 2937, 2878, 2784, 1811, 1751, 1716, 1673, 1530, 1499, 1455, 1367,
1322, 1284, 1257, 1234, 1218, 1167, 1141, 1109, 1082, 1047, 1005, 992, 954, 931, 897,
866, 832, 773, 755, 693, 666, 631, 573, 458, 408 (cm-1)
1H-NMR (CDCl3) δ (ppm): 0.85 (3H, t, J = 7.2 Hz), 1.00 (3H, d, J = 6.9 Hz), 1.21 (3H, d, J =
6.0 Hz), 1.25 (3H, d, J = 7.5 Hz), 1.27 (3H, d, J = 7.2 Hz), 1.36 (3H, d, J = 6.9 Hz), 1.39 (3H,
s), 1.44 (3H, d, J = 6.9 Hz), 1.56 (3H, s), 1.54-1.74 (4H, m), 1.87 (2H, m), 2.03 (2H, m),
2.26 (6H, s), 2.45 (1H, m), 2.55 (1H, q, J = 7.2 Hz), 2.67 (3H, s), 2.92 (2H, t, J = 7.5 Hz),
3.01 (1H, quintet, J = 7.5 Hz), 3.10-3.22 (2H, m), 3.46-3.58 (2H, m), 3.64-3.75 (1H, m),
3.82 (1H, q, J = 6.9 Hz), 4.21 (1H, d, J = 8.4 Hz), 4.29 (1H, d, J = 7.2 Hz), 4.49 (1H, q, J =
6.9 Hz), 4.84 (1H, s), 4.99 (1H, dd, J = 2.7 and 10.5 Hz), 7.20 (1H, brt, J = 5.7 Hz),
7.70 (1H, dd, J = 1.8 and 8.7 Hz), 7.91 (1H, d, J = 1.8 Hz), 8.01 (1H, d, J = 8.7 Hz),
8.27 (1H, d, J = 1.8 Hz), 8.30 (1H, d, J = 1.8 Hz)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.6, 15.8, 18.9, 19.9, 21.1, 22.3, 26.2,
28.3, 30.5, 33.1, 33.4, 37.9, 39.0, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 76.0, 78.4, 78.5,
82.4, 84.6, 103.7, 127.8, 129.1, 131.6, 141.8, 143.2, 144.1, 144.6, 144.8, 153.8, 166.4,
169.3, 172.2, 203.9

Example 7

Under a nitrogen atmosphere, HOBt 81mg, WSCD · HCl in a solution of 4Ab (383mg) dissolved in 9ml of CH2Cl2
115 mg was added and stirred at room temperature for 1 hour. 3-Quinoxalin-5-yl-propylamine 112mg
Was added to a solution of 3 ml of CH2Cl2 and the mixture was further stirred at room temperature for 2 hours. Saturated NH4Cl aqueous solution
And extracted with AcOEt, and the extract was washed with brine and dried over anhydrous MgSO4. Just
The solvent was distilled off under reduced pressure and silica gel column chromatography (hexane-acetate ester).
Chill-acetonitrile), and the solvent is distilled off under reduced pressure to give a white foamy compound
7Ab-3 (450 mg) was obtained. Next, in the same manner as the method of synthesizing 9Ab-2 from 7Ab-2 in Example 6,
9Ab-3 (270 mg) was obtained from 7Ab-3 (417 mg).
MS (FAB): 870+ (M + H +). HRMS (FAB): calcd for C45H68N5O12 870.4864 found 870.4867
IR (KBr): 3436, 2973, 2937, 2878, 2784, 1811, 1751, 1716, 1674, 1577, 1528, 1490, 1456,
1379, 1361, 1322, 1283, 1257, 1233, 1167, 1142, 1109, 1082, 1047, 1005, 993, 952, 931,
900, 865, 835, 801, 771, 682, 632, 573, 533, 453, 431 (cm-1)
1H-NMR (CDCl3) δ (ppm): 0.87 (3H, t, J = 7.2 Hz), 0.99 (3H, d, J = 6.6 Hz), 1.20 (3H, d, J =
6.0 Hz), 1.26 (3H, d, J = 6.3 Hz), 1.27 (3H, d, J = 7.5 Hz), 1.36 (3H, d, J = 7.2 Hz), 1.39 (3H,
s), 1.45 (3H, d, J = 6.9 Hz), 1.55 (3H, s), 1.55-1.74 (4H, m), 1.87 (1H, m), 1.97-2.08 (3H, m),
2.26 (6H, s), 2.44 (1H, m), 2.54 (1H, q, J = 7.2 Hz), 2.66 (3H, s), 3.01 (1H, m), 3.13-3.25 (2H,
m), 3.30 (2H, t, J = 7.5 Hz), 3.43-3.58 (2H, m), 3.63-3.74 (1H, m), 3.81 (1H, q, J = 6.3 Hz),
4.20 (1H, d, J = 8.1 Hz), 4.28 (1H, d, J = 7.2 Hz), 4.52 (1H, q, J = 6.9 Hz), 4.82 (1H, s),
4.94 (1H, dd, J = 2.7 and 10.2 Hz), 7.07 (1H, brt, J = 5.7 Hz), 7.67 (1H, dd, J = 2.7 and 7.2
Hz), 7.70 (1H, dd, J = 6.9 and 7.2 Hz), 7.94 (1H, dd, J = 2.7 and 6.9 Hz), 8.82 (1H, d, J =
1.8 Hz), 8.85 (1H, d, J = 1.8 Hz)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.2, 15.3, 15.7, 16.1, 18.9, 19.9, 21.1, 22.2, 26.3,
28.0, 28.2, 30.3, 33.0, 37.9, 39.0, 40.2, 47.7, 49.7, 51.0, 65.8, 69.5, 70.3, 75.9, 78.4, 78.5,
78.6, 82.4, 84.5, 103.8, 127.4, 129.3, 129.8, 141.2, 141.7, 143.1, 143.7, 144.5, 153.8,
166.3, 169.1, 172.0, 203.9

Example 8

Under a nitrogen atmosphere, a solution of 5B (300 mg) dissolved in 6 ml of THF was cooled under ice-cooling, and NaH 30 mg
And stirred for 20 minutes. Bromo-acetic acid 3-phenyl-propyl ester 105mg
A solution dissolved in 1 ml of THF was added dropwise, and the mixture was warmed to room temperature and stirred for 1 hour.
Stir. After cooling to room temperature, saturated aqueous NH4Cl solution is added, and AcOEt extraction is performed.
After washing, it was dried using anhydrous MgSO4. Then after distilling off the solvent under reduced pressure, silica gel
Separation and purification by column chromatography (hexane-ethyl acetate system)
The solvent was distilled off to obtain white foam compound 8Aa-1 (51 mg). Next, in Example 5, 7Aa-1 to 9Aa-1
In the same manner as the synthesized method, 10Aa-1 (12.4 mg) was obtained from 8Aa-1 (51 mg).
MS (SI): 805+ (M + H +). HRMS (SI): calcd for C42H65N2O13 805.4483 found 805.4486
IR (KBr): 3447, 2924, 2877, 2851, 2785, 1810, 1752, 1653, 1636, 1628, 1604, 1569, 1560,
1542, 1508, 1497, 1456, 1381, 1362, 1323, 1304, 1284, 1258, 1167, 1142, 1108, 1084,
1047, 1004, 993, 953, 932, 891, 860, 834, 800, 773, 748, 700, 632, 567, 529, 512, 455,
432, 411 (cm-1)
1H-NMR (CDCl3) δ (ppm): 0.89 (3H, t, J = 7.2 Hz), 1.03 (3H, d, J = 6.9 Hz), 1.23 (3H, d, J =
6.0 Hz), 1.25 (3H, d, J = 6.9 Hz), 1.27 (3H, d, J = 7.8 Hz), 1.37 (3H, d, J = 6.9 Hz), 1.42 (3H,
s), 1.54 (3H, s), 1.54-1.76 (4H, m), 1.82-2.05 (4H, m), 2.27 (6H, s), 2.50 (2H, m), 2.69 (2H, t,
J = 7.8 Hz), 2.72 (3H, s), 3.05 (1H, quintet, J = 7.8 Hz), 3.19 (1H, dd, J = 7.2 and 9.9 Hz),
3.48-3.74 (2H, m), 3.83 (1H, q, J = 6.9 Hz), 4.16 (2H, t, J = 6.6 Hz), 4.19 (1H, d, J = 7.8 Hz),
4.30 (1H, d, J = 7.2 Hz), 4.54 and 4.67 (2H, ABq, J = 16.5 Hz), 4.77 (1H, s), 5.02 (1H, dd, J
= 2.7 and 9.6 Hz), 7.12-7.32 (5H, m)
13C-NMR (CDCl3): δ (ppm) 10.4, 13.2, 14.3, 15.3, 15.8, 18.8, 19.7, 21.1, 22.5, 26.7, 28.2,
29.7, 30.1, 32.1, 38.3, 40.2, 47.8, 49.7, 51.1, 64.0, 65.9, 69.5, 70.3, 70.5, 76.4, 78.5, 79.5,
82.5, 84.8, 103.8, 126.0, 128.4, 128.5, 141.1, 154.3, 166.0, 169.1, 170.1, 204.1

Example 9

To a solution of 4Aa (200 mg) dissolved in 6 ml of CH3CN under a nitrogen atmosphere, 45 μl of NEt3,
DPPA (Diphenylphosphoryl azide) 64 μl was added and stirred at room temperature for 5 hours. To 50 ℃
The mixture was warmed and stirred for 3.5 hours, then cooled to room temperature, and dimethylamine aqueous solution (10 eq) was added to room temperature.
Stirred under for 10 minutes. Next, a saturated NH4Cl aqueous solution was added, and AcOEt extraction was performed.
After washing, it was dried using anhydrous MgSO4. Then after distilling off the solvent under reduced pressure, silica gel
Separation and purification by column chromatography (hexane-ethyl acetate system)
The solvent was distilled off to obtain white foam compound 11Aa-1 (119 mg). Next, in Example 5, 7Aa-1 to 9Aa-1
12Aa-1 (34 mg) was obtained from 11Aa-1 (86 mg) in the same manner as the method for synthesizing.
MS (FAB): 729+ (M + H +). HRMS (FAB): calcd for C35H61N4O12 729.4286 found 729.4285
IR (KBr): 3416, 2972, 2938, 2879, 2783, 1809, 1752, 1669, 1555, 1457, 1380, 1303, 1284,
1257, 1234, 1166, 1110, 1078, 1048, 987, 932, 893, 776, 695, 616, 529, 455 (cm-1)
1H-NMR (CDCl3) δ (ppm): 0.90 (3H, t, J = 7.5 Hz), 0.96 (3H, d, J = 6.9 Hz), 1.24 (6H, d, J =
6.3 Hz), 1.26 (3H, d, J = 7.2 Hz), 1.37 (3H, d, J = 6.9 Hz), 1.39 (3H, s), 1.56 (3H, s), 1.54-
1.72 (4H, m), 1.90 (2H, m), 2.29 (6H, s), 2.51 (2H, m), 2.60 (3H, s), 2.87 (6H, s), 2.86-
3.06 (2H, m), 3.20 (1H, dd, J = 7.5 and 10.2 Hz), 3.48-3.84 (4H, m), 3.83 (1H, q, J = 6.9 Hz),
4.18 (1H, d, J = 8.4 Hz), 4.27 (1H, d, J = 6.9 Hz), 4.80 (1H, s), 4.93 (1H, dd, J = 5.4 and
10.8 Hz), 5.03 (1H, dd, J = 2.7 and 10.5 Hz), 5.34 (1H, dd, J = 8.4 and 10.8 Hz), 6.01 (1H,
(dd, J = 5.4 and 8.4Hz)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 14.2, 15.4, 15.9, 18.8, 19.9, 21.2, 22.3, 26.4, 28.2,
32.9, 35.9, 38.1, 40.1, 47.9, 49.1, 51.0, 65.9, 69.4, 70.2, 74.0, 76.0, 78.5, 79.4, 82.9, 84.7,
103.8, 154.5, 157.4, 165.0, 169.2, 203.8

Example 10

Compound 3A (3.86 g) was dissolved in a mixed solution of 125 ml of ethyl acetate and 6.3 ml of methanol, and the temperature was -78 ° C.
Then, ozone gas was bubbled for 0.5 hour, and nitrogen gas was bubbled for 5 minutes.
To this reaction solution was added 5 ml of dimethyl sulfide at −78 ° C. and stirred.
Stir for 1.5 hours. Water was added to this, AcOEt extraction was performed, and the extract was dried using anhydrous Na2SO4.
Then, it concentrated under pressure reduction. After adding 40 ml of EtOH to the concentrate and cooling under ice cooling, 47.3 mg of NaBH4 was added.
The mixture was stirred for 0.5 hour under ice cooling. Slowly add 10% H3PO4 aqueous solution to this, then add AcOEt extract.
I put it out. The extract was washed with a saturated aqueous NaHCO3 solution and brine, and then dried using anhydrous Na2SO4.
Concentrated under reduced pressure. Then silica gel column chromatography (toluene-ethyl acetate system)
Then, the solvent was distilled off under reduced pressure to obtain white foam compound 13A (3.19 g).
MS (FAB): 927+ (M + H +). HRMS (FAB): calcd for C48H67N2O16 927.4491 found 927.4485
Anal Calcd for C48H66N2O16 (H2O) 0.3: C 61.83, H 7.20, N 3.00 Found C 61.78, H 7.10, N
3.06
IR (KBr): 3444, 3064, 3033, 2973, 2938, 2879, 1812, 1751, 1702, 1633, 1587, 1496, 1455,
1382, 1330, 1290, 1253, 1166, 1114, 1066, 991, 952, 933, 906, 827, 782, 769, 755, 740,
698, 622, 593, 563, 518, 455, 403 (cm-1)

Under a nitrogen atmosphere, a solution of 13A (513 mg) dissolved in AcOEt 5 ml was cooled and stirred under ice cooling,
NEt3 130 μl and MsCl 390 μl were added and the mixture was stirred for 0.5 hour under ice cooling. 10% H3PO4 aqueous solution to this
In addition, AcOEt extraction. After washing the extract with saturated aqueous NaHCO3 solution and brine, anhydrous Na2SO4 was added.
The resulting mixture was dried and concentrated under reduced pressure to give a white foamy compound (585 mg). Then this white foam compound
The product (585 mg) was dissolved in 5 ml of DMF, NaN3 (181 mg) was added, and the mixture was stirred at 80 ° C. for 2.5 hours.
did. After cooling to room temperature, AcOEt extraction was performed by adding 10% H3PO4 aqueous solution. Extract the saturated NaHCO3 water
After washing with the solution and brine, it was dried over anhydrous Na2SO4 and concentrated under reduced pressure. Next, Silage
Separation and purification by column chromatography (toluene-ethyl acetate system) to reduce solvent
Distillation under reduced pressure gave white foam compound 14A (357 mg).
MS (FAB): 952+ (M + H +). HRMS (FAB): calcd for C48H66N5O15 952.4555 found 952.4561
Anal Calcd for C48H65N5O15: C 60.56, H 6.88, N 7.36 Found C 60.39, H 6.86, N 7.40
IR (KBr): 3424, 3064, 3033, 2975, 2938, 2879, 2103, 1812, 1752, 1702, 1633, 1496, 1455,
1382, 1330, 1288, 1255, 1166, 1114, 1068, 1047, 1004, 991, 952, 933, 906, 827, 782, 769,
755, 738, 698, 622, 518, 457 (cm-1)

Example 11

Compound 14A (338 mg) is dissolved in 6 ml of THF, and 279 mg of PPh3 and 32 μl of H2O are added to the room overnight.
Stir in warm. After cooling this under ice cooling, 3-Phenyl-propionyl chloride 106μl, NEt3 148
μ was added and stirred at room temperature for 0.5 hour. Saturated NaHCO3 aqueous solution was added and extracted with AcOEt. Extract
After washing with a saturated aqueous NaHCO3 solution and brine, it was dried over anhydrous Na2SO4 and concentrated under reduced pressure.
Next, it is separated by silica gel column chromatography (toluene-ethyl acetate system).
And the solvent was distilled off under reduced pressure to obtain white foam compound 15Aa-1 (368 mg). Next in Example 5
In the same way as 7Aa-1 was synthesized from 9Aa-1, 15Aa-1 (346mg) to 16Aa-1 (211mg)
Obtained.
MS (FAB): 804+ (M + H +). HRMS (FAB): calcd for C42H66N3O12 804.4646 found 804.4642
IR (CHCl3): 3392, 3022, 2970, 2934, 2872, 1805, 1752, 1716, 1651, 1515, 1454, 1382,
1361, 1305, 1283, 1256, 1228, 1166, 1139, 1108, 1073, 1045, 1006, 990, 951, 929,
908 (cm-1)
1H-NMR (CDCl3) δ (ppm): 0.84 (3H, t, J = 7.2 Hz), 0.97 (3H, d, J = 6.9 Hz), 1.22 (3H, d, J =
6.3 Hz), 1.24 (3H, d, J = 7.2 Hz), 1.27 (3H, d, J = 7.5 Hz), 1.37 (3H, d, J = 7.2 Hz), 1.38 (3H,
s), 1.55 (3H, s), 1.54-1.70 (4H, m), 1.85 (2H, m), 2.26 (6H, s), 2.51 (2H, m), 2.64 (2H, t, J =
7.2 Hz), 2.65 (3H, s), 2.92-3.04 (4H, m), 3.18 (1H, dd, J = 7.2 and 10.2), 3.30-3.78 (4H, m),
3.82 (1H, q, J = 6.9 Hz), 4.05 (2H, t, J = 3.6 Hz), 4.21 (1H, d, J = 8.1 Hz), 4.29 (1H, d, J =
7.2 Hz), 4.79 (1H, s), 4.95 (1H, dd, J = 2.4 and 9.9 Hz), 6.80 (1H, brs), 7.12-7.30 (5H, m)
13C-NMR (CDCl3): δ (ppm) 10.0, 12.9, 14.0, 15.5, 18.5, 19.6, 21.0, 22.0, 25.7, 28.0, 31.5,
32.6, 37.2, 37.9, 40.0, 41.6, 47.5, 49.3, 50.8, 65.6, 69.3, 70.1, 71.6, 76.0, 78.2, 78.7, 82.9,
84.4, 103.6, 125.6, 128.0, 128.2, 141.1, 153.6, 165.5, 168.8, 172.4, 203.7

Example 12

Compound 14A (304 mg) is dissolved in 7 ml of THF, and 260 mg of PPh3 and 30 μl of H2O are added to the room overnight.
Stir in warm. After cooling this under ice cooling, 1-Imidazol-1-yl-3-
Quinoxalin-6-yl-propane-1-one solution (3-Quinoxalin-6-yl-propionic acid in 3 ml of CH3CN
Add 173mg and 1,1'-Carbonyldiimidazole 107mg and stir at room temperature for 4 hours)
And stirred at room temperature for 40 minutes. Saturated NaHCO3 aqueous solution was added and extracted with AcOEt. Extract
The extract was washed with a saturated aqueous NaHCO3 solution and brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure.
Then, it was separated by silica gel column chromatography (chloroform-methanol system).
After separation and purification, the solvent was distilled off under reduced pressure to obtain white foam compound 15Aa-2 (366 mg). Example 6
In the same manner as the method for synthesizing 9Ab-2 from 7Ab-2, 15Aa-2 (232mg) to 16Aa-2 (136mg)
Got.
MS (FAB): 856+ (M + H +). HRMS (FAB): calcd for C44H66N5O12 856.4708 found 856.4713
Anal Calcd for C44H65N5O12 (H2O) 1.2: C 60.22, H 7.74, N 7.98 Found C 60.17, H 7.50, N
7.82
IR (KBr): 3397, 2972, 2937, 2878, 2784, 1809, 1751, 1716, 1670, 1500, 1455, 1380, 1322,
1305, 1284, 1258, 1233, 1219, 1167, 1141, 1109, 1075, 1046, 1005, 992, 954, 930, 913,
866, 832, 799, 769, 754, 693, 666, 622, 580, 531, 512, 456, 407 (cm-1)
1H-NMR (CDCl3) δ (ppm): 0.77 (3H, t, J = 7.5 Hz), 0.96 (3H, d, J = 7.2 Hz), 1.20 (3H, d, J =
6.9 Hz), 1.24 (3H, d, J = 6.3 Hz), 1.26 (3H, d, J = 7.8 Hz), 1.36 (3H, d, J = 6.6 Hz), 1.38 (3H,
s), 1.54 (3H, s), 1.50-1.90 (6H, m), 2.28 (6H, s), 2.42-2.55 (2H, m), 2.65 (3H, s), 2.81 (2H, t, J
= 7.5 Hz), 3.00 (1H, quintet, J = 7.8 Hz), 3.19 (1H, dd, J = 7.5 and 10.2 Hz), 3.24 (2H, dt,
J = 3.6 and 8.1 Hz), 3.32-3.43 (1H, m), 3.48-3.76 (3H, m), 3.82 (1H, q, J = 6.6 Hz), 4.07 (2H,
t, J = 3.6 Hz), 4.21 (1H, d, J = 7.8 Hz), 4.29 (1H, d, J = 7.5 Hz), 4.79 (1H, s), 4.95 (1H, dd, J
= 2.7 and 10.2 Hz), 6.97 (1H, brs), 7.75 (1H, dd, J = 1.8 and 8.7 Hz), 7.97 (1H, d, J = 1.8
Hz), 8.00 (1H, d, J = 8.7 Hz), 8.76 (1H, d, J = 1.8 Hz), 8.79 (1H, d, J = 1.8 Hz)
13C-NMR (CDCl3): δ (ppm) 9.9, 12.9, 14.1, 15.4, 15.5, 18.5, 19.7, 21.0, 22.0, 25.7, 28.0, 31.5,
32.6, 36.3, 37.9, 40.0, 41.8, 47.5, 49.4, 50.8, 65.7, 69.3, 70.1, 71.6, 76.0, 78.2, 78.7, 82.9,
84.5, 103.6, 127.8, 128.8, 131.7, 141.6, 143.0, 143.9, 144.0, 144.6, 153.7, 165.7, 169.0,
172.0, 203.7

Example 13

Compound 14A (415 mg) is dissolved in 8 ml of THF, and 344 mg of PPh3 and 39 μl of H2O are added to the room overnight.
Stir in warm. After cooling this under ice cooling, NEt3 182μl, trans-β-styrenesulfonyl chloride
176 mg was added and stirred at room temperature for 20 minutes. Extract with AcOEt by adding 10% H3PO4 aqueous solution. Extraction
The solution was washed with saturated aqueous NaHCO3 solution and brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure.
It was. Then, it was separated by silica gel column chromatography (toluene-ethyl acetate system)
After separation and purification, the solvent was distilled off under reduced pressure to obtain white foam compound 18Aa-1 (275 mg). Example 5
In the same manner as the method for synthesizing 9Aa-1 from 7Aa-1 in the same manner, 18Aa-1 (246mg) to 19Aa-1 (74mg)
Got.
MS (FAB): 840+ (M + H +). HRMS (FAB): calcd for C41H66N3O13S1 840.4316 found 840.4316
IR (CHCl3): 3020, 2970, 2934, 2872, 1804, 1752, 1714, 1454, 1381, 1361, 1323, 1281,
1232, 1229, 1161, 1108, 1071, 1046, 1006, 988, 952 (cm-1)
1H-NMR (CDCl3) δ (ppm): 0.89 (3H, t, J = 7.2 Hz), 0.97 (3H, d, J = 6.9 Hz), 1.20 (3H, d, J =
6.9 Hz), 1.24 (3H, d, J = 6.9 Hz), 1.27 (3H, d, J = 9.0 Hz), 1.37 (3H, d, J = 7.2 Hz), 1.38 (3H,
s), 1.55 (3H, s), 1.54-1.74 (4H, m), 1.90 (2H, m), 2.27 (6H, s), 2.40-2.59 (2H, m), 2.71 (3H, s),
3.03 (1H, quintet, J = 7.8 Hz), 3.12-3.21 (3H, m), 3.36-3.70 (7H, m), 3.83 (1H, q, J = 6.9
Hz), 4.10 (2H, t, J = 4.2 Hz), 4.22 (1H, d, J = 7.8 Hz), 4.30 (1H, d, J = 7.2 Hz), 4.79 (1H, s),
5.05 (1H, dd, J = 2.7 and 10.2 Hz), 5.35 (1H, brt, J = 6.9 Hz), 7.21-7.34 (5H, m)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.2, 15.5, 18.6, 19.7, 21.1, 22.2, 25.9, 28.1, 29.8,
32.9, 38.1, 40.1, 44.2, 47.5, 49.6, 50.9, 54.2, 65.7, 69.4, 70.2, 76.3, 78.2, 78.8, 82.8, 84.5,
103.6, 126.5, 128.3, 128.6, 138.2, 153.7, 166.1, 168.9, 203.9

Example 14

In the same manner as in the method of synthesizing 9Aa-1 from 7Aa-1 in Example 5, 4Aa (350 mg) to 20 Aa (58 mg)
Got.
MS (SI): 687+ (M + H +). HRMS (SI): calcd for C33H55N2O13 687.3700 found 687.3698
IR (KBr): 3428, 2973, 2936, 2879, 2855, 1806, 1750, 1716, 1601, 1457, 1381, 1318, 1285,
1235, 1165, 1109, 1081, 1048, 1005, 994, 954, 934, 893, 774, 697, 612, 499, 428 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.2, 14.3, 15.4, 16.0, 18.6, 19.8, 20.9, 22.4, 26.5, 29.4,
33.2, 38.3, 39.7, 47.9, 49.6, 51.1, 57.9, 66.1, 68.3, 69.6, 76.4, 78.5, 79.7, 83.2, 85.1, 103.1,
154.7, 165.3, 169.3, 177.1, 204.1

Example 15
The physical property of an intermediate compound is shown.
I (4)
4Ac

MS (FAB): 955+ (M + H +). HRMS (FAB): calcd for C49H67N2O17 955.4440 found 955.4442
Anal Calcd for C49H66N2O17 (H2O) 1.4: C 60.04, H 7.07, N 2.86. Found: C 60.08, H 6.73, N
2.86.
IR (KBr): 3429, 3065, 3033, 2977, 2939, 2881, 1812, 1752, 1704, 1587, 1497, 1455, 1382,
1331, 1289, 1254, 1166, 1113, 1083, 1068, 1048, 1003, 953, 899, 826, 782, 769, 755, 739,
698, 624, 595, 575, 518, 458 (cm-1)

4Ad

MS (FAB): 969+ (M + H +). HRMS (FAB): calcd for C50H69N2O17 969.4596 found 969.4603
Anal Calcd for C50H68N2O17 (H2O) 0.5: C 61.40, H 7.11, N 2.86. Found: C 61.37, H 7.10, N
2.87.
IR (KBr): 3422, 3065, 3033, 2975, 2938, 2880, 1813, 1752, 1704, 1497, 1456, 1383, 1330,
1291, 1254, 1167, 1114, 1083, 1066, 989, 953, 934, 909, 826, 782, 769, 754, 739, 698,
625, 595, 576, 518, 457 (cm-1)

4Ae

MS (FAB): 969+ (M + H +). HRMS (FAB): calcd for C50H69N2O17 969.4596 found 969.4614
Anal Calcd for C50H68N2O17 (H2O) 0.8: C 61.06, H 7.13, N 2.85.Found: C 61.04, H 6.98, N
2.87.
IR (KBr): 3428, 3065, 3032, 2975, 2938, 2880, 1811, 1752, 1704, 1587, 1497, 1455, 1382,
1330, 1291, 1253, 1167, 1113, 1083, 1066, 989, 954, 934, 910, 782, 769, 754, 739, 698,
625, 518, 457 (cm-1)

4Af

MS (FAB): 983+ (M + H +). HRMS (FAB): calcd for C51H71N2O17 983.4753 found 983.4745
IR (KBr): 3429, 3065, 3033, 2973, 2938, 2879, 1812, 1752, 1705, 1497, 1456, 1383, 1330,
1291, 1254, 1167, 1114, 1067, 990, 933, 913, 782, 769, 754, 739, 698 (cm-1)

4Ag

MS (FAB): 983+ (M + H +). HRMS (FAB): calcd for C51H71N2O17 983.4753 found 983.4750
IR (KBr): 3427, 3065, 3033, 2973, 2938, 2879, 1812, 1752, 1705, 1497, 1455, 1382, 1330,
1291, 1254, 1168, 1114, 1067, 1049, 991, 933, 912, 782, 769, 754, 697, 533, 516,
457 (cm-1)

Example 16
The following compounds were synthesized according to the above examples.

II (7)
I-1

MS (SI): 686+ (M + H +). HRMS (SI): calcd for C33H55N3O12 686.3860 found 686.3860
IR (KBr): 3451, 2974, 2938, 2880, 2786, 1810, 1751, 1689, 1632, 1591, 1457, 1380, 1324,
1284, 1257, 1231, 1166, 1110, 1078, 1048, 994, 954, 933, 889, 834, 776, 695, 618, 531,
457 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 14.3, 15.3, 15.5, 18.8, 19.9, 21.1, 22.3, 26.4, 28.3,
33.2, 38.0, 40.1, 47.5, 49.7, 51.0, 65.8, 69.4, 70.2, 72.7, 76.1, 78.4, 78.5, 82.3, 84.7, 103.6,
153.9, 167.5, 169.2, 173.0, 204.0

I-2

MS (FAB): 714+ (M + H +). HRMS (FAB): calcd for C35H60N3O12 714.4177 found 714.4173
IR (KBr): 3435, 2973, 2937, 2879, 2786, 1809, 1752, 1716, 1654, 1456, 1379, 1324, 1283,
1260, 1229, 1166, 1110, 1079, 1049, 994, 954, 932, 892, 834, 776, 692, 623, 581, 529,
454 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.2, 15.3, 15.7, 18.7, 19.7, 21.1, 22.3, 26.4, 28.2,
33.0, 35.3, 36.6, 38.2, 40.1, 47.7, 49.6, 51.0, 65.7, 69.3, 70.2, 71.1, 76.2, 78.4, 79.2, 82.6,
84.6, 103.6, 154.3, 165.6, 168.8, 169.0, 203.9

I-3

MS (FAB): 818+ (M + H +). HRMS (FAB): calcd for C43H68N3O12 818.4803 found 818.4801
IR (KBr): 3435, 2973, 2937, 2879, 2786, 1809, 1752, 1716, 1654, 1456, 1379, 1324, 1283,
1260, 1229, 1166, 1110, 1079, 1049, 994, 954, 932, 892, 834, 776, 692, 623, 581, 529,
454 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 12.7, 14.1, 15.1, 15.5, 18.6, 19.7, 21.0, 22.1, 26.1, 28.0,
28.5, 28.9, 32.9, 35.2, 37.8, 38.7, 40.0, 47.4, 49.6, 50.8, 65.6, 69.3, 70.0, 72.7, 75.9, 78.2,
78.5, 82.1, 84.4, 103.5, 125.4, 128.0, 128.2, 142.1, 153.6, 167.3, 169.0, 170.0, 203.7
I-4

MS (FAB): 762+ (M + H +). HRMS (FAB): calcd for C39H60N3O12 762.4177 found 762.4174
IR (KBr): 3413, 3361, 2972, 2936, 2879, 2786, 1810, 1751, 1714, 1685, 1636, 1600, 1536,
1499, 1456, 1444, 1379, 1361, 1320, 1284, 1256, 1235, 1167, 1141, 1109, 1078, 1047,
1006, 993, 951, 932, 892, 858, 835, 756, 695, 635, 618, 580, 565, 507, 457, 426 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.3, 15.5, 15.6, 18.8, 19.9, 21.1, 22.3, 26.5, 28.3,
33.2, 38.1, 40.1, 47.6, 49.7, 51.0, 65.8, 69.4, 70.2, 73.5, 76.1, 78.4, 78.6, 82.3, 84.6, 103.7,
120.1, 124.3, 128.9, 137.3, 153.9, 168.4, 168.6, 169.1, 203.8

I-5

MS (FAB): 790+ (M + H +). HRMS (FAB): calcd for C41H64N3O12 790.4490 found 790.4492
IR (KBr): 3432, 3062, 2973, 2937, 2879, 2784, 1810, 1751, 1716, 1675, 1604, 1531, 1496,
1455, 1380, 1363, 1322, 1305, 1284, 1257, 1234, 1166, 1141, 1110, 1078, 1047, 1004,
993, 954, 931, 894, 835, 773, 752, 700, 630, 570, 532, 457 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 14.2, 15.3, 15.6, 18.8, 19.8, 21.1, 22.3, 26.3, 28.3,
33.1, 35.6, 38.0, 40.1, 40.2, 47.6, 49.6, 51.0, 65.8, 69.4, 70.2, 72.9, 76.1, 78.3, 78.6, 82.3,
84.6, 103.7, 126.2, 128.4, 128.7, 138.9, 153.9, 167.4, 169.2, 170.1, 203.9

I-6

MS (FAB): 804+ (M + H +). HRMS (FAB): calcd for C42H66N3O12 804.4647 found 804.4650
IR (KBr): 3433, 3061, 2973, 2936, 2878, 2785, 1809, 1751, 1716, 1671, 1536, 1495, 1455,
1380, 1321, 1284, 1259, 1232, 1166, 1110, 1078, 1048, 994, 954, 932, 892, 775, 750, 700,
628, 559, 532, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 14.3, 15.4, 15.6, 18.8, 19.9, 21.1, 22.3, 26.3, 28.5,
30.9, 33.1, 38.0, 38.8, 40.1, 47.6, 49.8, 51.0, 65.9, 69.3, 70.2, 73.0, 76.1, 78.4, 78.6, 82.3,
84.5, 103.6, 125.7, 128.3, 128.4, 141.5, 153.8, 167.5, 169.2, 170.3, 203.9

I-7

MS (FAB): 729+ (M + H +). HRMS (FAB): calcd for C35H61N4O12 729.4286 found 729.4282
IR (KBr): 3434, 2973, 2938, 2879, 2783, 1811, 1752, 1690, 1637, 1527, 1456, 1381, 1362,
1323, 1304, 1284, 1258, 1233, 1219, 1166, 1142, 1109, 1080, 1048, 1005, 993, 953, 932,
891, 860, 835, 774, 694, 627, 581, 563, 532, 456 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.2, 15.4, 15.6, 18.9, 19.9, 21.1, 22.2, 26.4, 28.4,
33.1, 38.6, 40.1, 47.5, 47.7, 50.1, 51.0, 65.9, 69.4, 70.2, 72.6, 76.0, 78.4, 78.8, 82.4, 84.6,
103.7, 153.8, 168.0, 168.2, 169.3, 203.7

I-8

MS (FAB): 826+ (M + H +). HRMS (FAB): calcd for C42H66F2N3O11 826.4665 found 826.4671
IR (KBr): 3437, 3062, 2974, 2938, 2878, 2786, 1752, 1717, 1674, 1534, 1497, 1455, 1380,
1362, 1325, 1305, 1255, 1221, 1166, 1141, 1108, 1079, 1050, 991, 951, 898, 834, 747,
700, 627, 554, 512, 430, 407 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.4, 14.3, 15.6, 16.4, 19.1, 19.9, 21.1, 22.1, 26.4, 28.2,
31.0, 33.2, 33.7, 38.1, 38.8, 40.2, 47.6, 49.8, 51.2, 65.8, 69.5, 70.3, 72.9, 76.3, 76.4, 78.3,
78.7, 85.4, 85.5, 87.0, 103.7, 125.7, 126.3, 128.2, 128.3, 129.5, 132.7, 141.5, 168.1, 169.2,
170.5, 204.2

I-9

MS (FAB): 776+ (M + H +). HRMS (FAB): calcd for C40H62N3O12 776.4333 found 776.4338
IR (KBr): 3435, 2974, 2938, 2879, 1810, 1751, 1715, 1675, 1530, 1455, 1379, 1323, 1283,
1258, 1231, 1166, 1110, 1078, 1048, 994, 954, 932, 891, 775, 752, 700, 582, 530,
456 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.4, 13.0, 14.2, 15.3, 15.5, 18.7, 19.8, 21.1, 22.4, 26.3, 28.2,
33.1, 38.0, 40.1, 43.2, 47.5, 49.6, 51.0, 65.8, 69.4, 70.2, 72.9, 76.3, 78.2, 78.5, 82.4, 84.4,
103.6, 127.4, 128.1, 128.6, 137.9, 153.8, 167.7, 168.9, 170.1, 204.0

I-10

MS (SI): 847+ (M + H +). HRMS (SI): calcd for C44H71N4O12 847.4986 found 846.4993
IR (KBr): 3451, 2974, 2938, 2880, 2786, 1810, 1751, 1689, 1632, 1591, 1457, 1380, 1324,
1284, 1257, 1231, 1166, 1110, 1078, 1048, 994, 954, 933, 889, 834, 776, 695, 618, 531,
457 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.2, 15.3, 15.5, 18.7, 19.7, 21.0, 22.2, 26.2, 28.1,
29.5, 31.0, 31.9, 33.1, 37.9, 38.7, 40.0, 40.8, 47.5, 49.6, 50.9, 65.7, 69.3, 70.1, 72.9, 76.0,
78.3, 78.6, 82.2, 84.4, 103.6, 113.0, 128.8, 129.6, 148.9, 153.7, 167.3, 169.0, 170.0, 203.8

I-11

MS (FAB): 854+ (M + H +). HRMS (FAB): calcd for C46H68N3O12 854.4803 found 854.4799
IR (KBr): 3435, 2972, 2937, 2877, 1811, 1751, 1716, 1675, 1532, 1456, 1380, 1362, 1323,
1304, 1283, 1258, 1233, 1219, 1167, 1142, 1109, 1078, 1048, 1004, 993, 953, 931, 893,
799, 779, 555, 532 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 14.3, 15.4, 15.6, 18.9, 19.9, 21.1, 22.3, 26.4, 28.2,
30.2, 33.2, 38.0, 39.1, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 73.0, 76.1, 78.4, 78.7, 82.3,
84.6, 103.7, 123.7, 125.4, 125.5, 125.8, 125.9, 126.6, 128.7, 131.8, 133.8, 137.5, 153.8,
167.5, 169.2, 170.3, 203.9

I-12

MS (FAB): 880+ (M + H +). HRMS (FAB): calcd for C48H70N3O12 880.4960 found 880.4963
IR (KBr): 3433, 3025, 2973, 2936, 2878, 1811, 1751, 1716, 1675, 1531, 1494, 1455, 1378,
1323, 1304, 1282, 1258, 1232, 1166, 1109, 1078, 1048, 994, 953, 891, 774, 752, 701,
535 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.3, 26.3, 28.2,
33.1, 34.8, 38.0, 38.2, 40.2, 47.6, 49.1, 49.8, 51.0, 65.8, 69.5, 70.3, 73.0, 76.0, 78.4, 78.6,
82.4, 84.5, 103.7, 126.1, 127.7, 127.8, 128.4, 144.4, 153.7, 167.4, 169.1, 170.2, 203.9

I-13

MS (FAB): 778+ (M + H +). HRMS (FAB): calcd for C41H68N3O11 778.4854 found 778.4852
IR (KBr): 3435, 3085, 3061, 3025, 2974, 2938, 2876, 2785, 1744, 1714, 1683, 1604, 1531,
1497, 1455, 1403, 1377, 1337, 1302, 1280, 1258, 1172, 1109, 1076, 1051, 1034, 986, 958,
938, 915, 892, 835, 748, 721, 701, 617, 578, 531, 491 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.6, 13.8, 14.5, 15.0, 16.2, 18.6, 19.7, 21.2, 21.4, 26.7, 28.3,
31.1, 33.1, 33.3, 37.8, 38.5, 40.2, 46.1, 49.8, 50.8, 65.8, 69.4, 70.1, 70.3, 72.7, 73.8, 78.0,
78.1, 103.3, 125.9, 128.2, 128.3, 141.2, 169.5, 172.7, 205.5

I-14

MS (FAB): 794+ (M + H +). HRMS (FAB): calcd for C39H64N5O12 794.4551 found 794.4552
IR (KBr): 3430, 3112, 2971, 2933, 2879, 2786, 1806, 1751, 1714, 1673, 1536, 1455, 1378,
1321, 1284, 1257, 1232, 1166, 1110, 1078, 1049, 995, 954, 933, 892, 833, 775, 752, 692,
665, 624, 561, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.3,
29.6, 30.9, 33.1, 36.3, 37.9, 40.2, 44.7, 47.6, 49.7, 51.0, 65.8, 69.5, 70.2, 72.8, 75.9, 78.5,
82.3, 84.7, 103.7, 119.2, 129.3, 153.8, 167.7, 169.4, 170.8, 203.8

I-15

MS (FAB): 832+ (M + H +). HRMS (FAB): calcd for C44H70N3O12 832.4959 found 832.4968
IR (KBr): 3435, 2972, 2936, 2877, 2857, 2785, 1811, 1751, 1717, 1671, 1534, 1496, 1455,
1380, 1362, 1323, 1304, 1283, 1258, 1234, 1219, 1167, 1142, 1109, 1078, 1048, 1004,
992, 953, 932, 893, 835, 773, 749, 700, 627, 569, 531, 513, 455, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.6, 18.9, 19.9, 21.1, 22.3, 26.3, 26.6,
28.1, 29.3, 31.1, 33.1, 35.7, 38.0, 39.1, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 73.0, 76.1,
78.4, 78.7, 82.3, 84.5, 103.8, 125.5, 128.1, 128.4, 142.6, 153.8, 167.4, 169.2, 170.2, 203.9

I-16

MS (FAB): 805+ (M + H +). HRMS (FAB): calcd for C41H65N4O12 805.4599 found 805.4604
IR (KBr): 3432, 2971, 2934, 2877, 2784, 1809, 1751, 1716, 1674, 1603, 1534, 1456, 1416,
1378, 1322, 1305, 1284, 1259, 1222, 1166, 1110, 1078, 1048, 994, 954, 933, 891, 800,
776, 629, 578, 512 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.3,
29.6, 32.4, 33.1, 37.9, 38.7, 40.1, 47.6, 49.8, 51.0, 65.8, 69.4, 70.2, 72.9, 75.9, 78.4, 78.6,
82.3, 84.6, 103.7, 123.9, 149.5, 153.8, 167.6, 169.3, 170.5, 203.8

I-17

MS (SI): 805+ (M + H +). HRMS (SI): calcd for C41H65N4O12 805.4595 found 805.4606
IR (KBr): 3433, 2972, 2937, 2878, 2784, 1810, 1751, 1716, 1673, 1575, 1534, 1456, 1423,
1380, 1363, 1322, 1305, 1284, 1258, 1234, 1220, 1167, 1142, 1109, 1079, 1048, 1005,
993, 953, 931, 893, 774, 714, 629, 558, 532 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.3,
30.2, 30.6, 33.1, 37.9, 38.6, 40.1, 47.6, 49.8, 51.0, 65.8, 69.4, 70.2, 72.9, 75.9, 78.4, 78.6,
82.3, 84.6, 103.7, 123.3, 135.9, 136.9, 147.2, 149.7, 153.8, 167.6, 169.3, 170.4, 203.8

I-18

MS (FAB): 802+ (M + H +). HRMS (FAB): calcd for C42H64N3O12 802.4490 found 802.4489
IR (KBr): 3436, 2974, 2938, 2879, 2785, 1811, 1752, 1717, 1677, 1525, 1495, 1455, 1380,
1362, 1324, 1304, 1283, 1257, 1233, 1167, 1141, 1109, 1078, 1047, 1004, 992, 931, 892,
859, 835, 801, 773, 748, 694, 630, 556, 512, 456, 432 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.0, 12.9, 14.3, 15.3, 15.5, 18.8, 19.9, 21.1, 22.1, 26.3, 28.2,
33.2, 38.0, 40.2, 41.4, 47.5, 49.8, 51.0, 65.9, 69.5, 70.2, 73.0, 75.9, 78.4, 78.5, 82.4, 84.5,
103.7, 125.0, 126.5, 127.4, 128.4, 132.6, 136.6, 153.7, 167.6, 169.0, 170.2, 204.0

I-19

MS (FAB): 806+ (M + H +). HRMS (FAB): calcd for C41H64N3O13 806.4439 found 806.4441
IR (KBr): 3438, 2973, 2937, 2878, 2785, 1811, 1751, 1717, 1679, 1637, 1599, 1588, 1528,
1497, 1457, 1380, 1363, 1324, 1303, 1285, 1244, 1169, 1141, 1109, 1078, 1048, 1004,
993, 953, 931, 891, 773, 755, 693, 555, 512 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.2, 15.2, 15.5, 18.8, 19.8, 21.1, 22.2, 26.4, 28.1,
33.2, 38.0, 38.4, 40.1, 47.5, 49.6, 51.0, 65.7, 66.3, 69.4, 70.1, 72.7, 76.0, 78.2, 78.5, 82.1,
84.4, 103.4, 114.2, 120.6, 129.2, 153.6, 158.2, 167.3, 168.8, 170.1, 203.6

I-20

MS (FAB): 800+ (M + H +). HRMS (FAB): calcd for C42H62N3O12 800.4334 found 800.4336
IR (KBr): 3442, 2974, 2938, 2879, 2839, 2785, 1811, 1752, 1716, 1683, 1599, 1522, 1490,
1456, 1381, 1361, 1324, 1304, 1282, 1257, 1233, 1167, 1141, 1109, 1078, 1047, 1004,
993, 953, 931, 915, 892, 859, 835, 801, 758, 693, 669, 628, 556, 527, 456 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 12.9, 14.3, 15.3, 15.4, 18.8, 19.8, 21.1, 22.2, 26.4, 28.2,
29.5, 33.3, 38.0, 40.2, 47.5, 49.8, 51.0, 65.8, 69.4, 70.2, 72.8, 76.0, 78.3, 78.5, 82.3, 83.0,
84.5, 103.7, 122.7, 128.1, 128.2, 131.8, 153.8, 167.8, 169.0, 170.0, 204.0

I-21

MS (FAB): 802+ (M + H +). HRMS (FAB): calcd for C42H64N3O12 802.4490 found 802.4493
IR (KBr): 3436, 3055, 2973, 2938, 2879, 2785, 1811, 1751, 1717, 1676, 1527, 1494, 1456,
1381, 1363, 1325, 1304, 1283, 1257, 1233, 1166, 1141, 1109, 1078, 1047, 1004, 993, 953,
932, 891, 860, 835, 803, 773, 701, 628, 531, 456, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.3, 26.3, 28.2,
33.2, 37.4, 38.0, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.2, 72.9, 76.1, 78.3, 78.6, 82.3, 84.5,
103.7, 127.0, 127.8, 128.2, 128.7, 131.5, 136.3, 153.7, 167.5, 169.0, 170.1, 204.0

I-22

MS (SI): 855+ (M + H +). HRMS (SI): calcd for C45H67N4O12 855.4751 found 855.4749
IR (KBr): 3434, 2971, 2935, 2877, 2854, 2784, 1811, 1751, 1717, 1673, 1591, 1533, 1509,
1456, 1380, 1362, 1322, 1305, 1284, 1257, 1234, 1219, 1167, 1141, 1109, 1078, 1048,
1004, 992, 953, 931, 892, 835, 771, 628, 557, 532, 455 (cm-1)
1H-NMR (CDCl3) δ (ppm): 0.87 (3H, t, J = 7.2 Hz), 1.00 (3H, d, J = 6.9 Hz), 1.23 (3H, d, J =
6.0 Hz), 1.24 (3H, d, J = 7.5 Hz), 1.28 (3H, d, J = 7.2 Hz), 1.37 (3H, d, J = 7.2 Hz), 1.39 (3H,
s), 1.56 (3H, s), 1.54-2.12 (8H, m), 2.27 (6H, s), 2.46 (1H, m), 2.56 (1H, q, J = 7.2 Hz),
2.69 (3H, s), 3.01 (1H, quintet, J = 7.5 Hz), 3.13 (2H, dd, J = 4.2 and 8.4 Hz), 3.18 (1H, dd,
J = 7.5 and 9.9 Hz), 3.33 (1H, m), 3.54 (3H, m), 3.68 (1H, m), 3.83 (1H, q, J = 6.9 Hz),
4.22 (1H, d, J = 8.1 Hz), 4.29 (1H, d, J = 7.5 Hz), 4.44 and 4.49 (2H, Abq, J = 14.1 Hz),
4.85 (1H, s), 4.99 (1H, dd, J = 2.7 and 10.5 Hz), 7.23 (1H, brt, J = 6.3 Hz), 7.31 (1H, d, J =
4.5 Hz), 7.57 (1H, m), 7.69 (1H, m), 8.05 (1H, dd, J = 0.9 and 8.4 Hz), 8.09 (1H, d, J = 8.1
Hz), 8.81 (1H, d, J = 4.5 Hz)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.2,
29.3, 29.7, 33.1, 38.0, 39.0, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 73.0, 75.9, 78.4, 78.6,
82.3, 84.6, 103.7, 120.6, 123.5, 126.3, 127.5, 128.9, 130.0, 147.5, 148.2, 150.2, 153.8,
167.6, 169.3, 170.5, 203.8

I-23

MS (SI): 873+ (M + H +). HRMS (SI): calcd for C46H73N4O12 873.5221 found 873.5225
IR (KBr): 3435, 2971, 2936, 2876, 2789, 1811, 1751, 1717, 1673, 1602, 1570, 1533, 1505,
1455, 1380, 1362, 1323, 1305, 1284, 1258, 1233, 1216, 1167, 1141, 1109, 1078, 1047,
1004, 992, 953, 931, 893, 835, 773, 749, 695, 627, 553, 531, 456, 407 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 14.3, 15.3, 15.6, 18.9, 19.9, 21.2, 22.3, 26.0, 26.1,
26.3, 27.1, 28.2, 29.7, 33.1, 33.6, 33.7, 35.9, 38.0, 38.8, 39.3, 40.2, 47.4, 47.6, 49.8, 49.9,
51.1, 65.9, 69.5, 70.3, 73.0, 76.1, 78.4, 78.7, 82.3, 84.5, 103.7, 110.7, 115.8, 126.6, 127.0,
128.5, 128.6, 145.8, 153.8, 167.4, 169.2, 170.2, 203.9

I-24

MS (FAB): 818+ (M + H +). HRMS (FAB): calcd for C43H68N3O12 818.4803 found 818.4803
IR (CHCl3): 3426, 3350, 2970, 2934, 2870, 2830, 2780, 1805, 1751, 1715, 1663, 1536,
1490, 1455, 1381, 1361, 1345, 1322, 1305, 1282, 1256, 1230, 1220, 1165, 1139, 1107,
1074, 1046, 1004, 990, 950, 931, 907, 831, 666, 627, 560, 543, 536, 529, 524, 518, 514,
512 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.2, 15.3, 15.6, 18.8, 19.2, 19.9, 21.1, 22.2, 26.3,
28.1, 29.7, 30.4, 33.1, 38.0, 39.0, 40.2, 47.6, 49.7, 51.0, 65.8, 69.5, 70.2, 73.0, 76.0, 78.3,
78.6, 82.3, 84.5, 103.7, 125.8, 128.6, 130.0, 135.8, 139.6, 153.8, 167.4, 169.1, 170.2,
203.9

I-25

MS (FAB): 818+ (M + H +). HRMS (FAB): calcd for C43H68N3O12 818.4803 found 818.4802
IR (CHCl3): 3426, 3350, 2998, 2970, 2934, 2870, 2782, 1805, 1751, 1715, 1663, 1607,
1536, 1454, 1381, 1361, 1345, 1322, 1305, 1282, 1255, 1229, 1219, 1165, 1139, 1107,
1075, 1046, 1004, 990, 950, 930, 907, 832, 723, 697, 667, 628, 550, 529, 525, 518, 514,
508 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.2, 15.3, 15.6, 18.8, 19.9, 21.1, 21.3, 22.3, 26.3,
28.1, 30.9, 33.1, 33.2, 38.0, 38.8, 40.2, 47.6, 49.7, 51.0, 65.8, 69.5, 70.2, 73.0, 76.0, 78.4,
78.7, 82.3, 84.5, 103.7, 125.3, 126.5, 128.1, 129.1, 137.7, 141.4, 153.8, 167.4, 169.1,
170.2, 203.9

I-26

MS (FAB): 818+ (M + H +). HRMS (FAB): calcd for C43H68N3O12 818.4803 found 818.4799
IR (CHCl3): 3426, 3354, 2970, 2934, 2870, 2780, 1805, 1751, 1715, 1663, 1537, 1515,
1454, 1380, 1361, 1345, 1323, 1305, 1282, 1256, 1230, 1220, 1165, 1139, 1107, 1075,
1046, 1004, 990, 950, 930, 907, 832, 665, 626, 553, 540, 537, 532, 523, 517, 513,
508 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.2, 15.3, 15.6, 18.8, 19.9, 20.9, 21.1, 22.2, 26.3,
28.1, 30.9, 32.7, 33.1, 38.0, 38.7, 40.2, 47.6, 49.7, 51.0, 65.8, 69.5, 70.2, 72.9, 76.0, 78.4,
78.7, 82.3, 84.5, 103.7, 128.2, 128.9, 135.0, 138.4, 153.8, 167.5, 169.1, 170.2, 203.9

I-27

MS (FAB): 810+ (M + H +). HRMS (FAB): calcd for C42H72N3O12 810.5116 found 810.5117
IR (KBr): 3439, 2973, 2929, 2851, 2786, 1814, 1752, 1717, 1674, 1533, 1455, 1380, 1362,
1323, 1304, 1284, 1258, 1233, 1219, 1167, 1142, 1109, 1078, 1048, 1004, 992, 953, 931,
891, 860, 835, 801, 773, 755, 694, 629, 555, 532, 457, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.3, 26.3, 26.6,
26.8, 28.2, 33.1, 33.2, 34.6, 37.3, 38.0, 39.5, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 73.0,
76.1, 78.4, 78.7, 82.3, 84.5, 103.7, 153.8, 167.4, 169.1, 170.1, 203.9

I-28

MS (FAB): 821+ (M + H +). HRMS (FAB): calcd for C41H65N4O13 821.4548 found 821.4550
IR (CHCl3): 3422, 3348, 2970, 2934, 2870, 2832, 1802, 1751, 1715, 1657, 1584, 1538,
1455, 1381, 1360, 1344, 1323, 1304, 1282, 1232, 1219, 1165, 1107, 1078, 1047, 1005,
990, 950, 930, 907, 725, 666, 525, 521 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.2, 15.3, 15.6, 18.7, 19.8, 21.1, 22.2, 26.4, 28.1,
29.5, 33.1, 35.3, 38.1, 40.2, 46.6, 47.6, 49.6, 51.0, 65.7, 69.4, 70.2, 72.7, 76.1, 78.4, 78.8,
82.5, 84.6, 103.7, 106.1, 120.6, 137.9, 139.4, 154.0, 162.8, 167.2, 169.2, 170.4, 203.9

I-29

MS (FAB): 821+ (M + H +). HRMS (FAB): calcd for C41H65N4O13 821.4548 found 821.4545
IR (CHCl3): 3332, 2970, 2936, 2870, 1804, 1750, 1663, 1639, 1564, 1455, 1381, 1363,
1347, 1323, 1305, 1282, 1256, 1233, 1219, 1186, 1167, 1139, 1107, 1073, 1048, 1005,
990, 951, 907, 848, 723, 665 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.7, 14.3, 15.2, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.3,
30.7, 33.1, 35.9, 37.8, 40.2, 47.6, 49.7, 51.0, 54.6, 65.8, 69.5, 70.2, 72.7, 75.8, 78.5, 78.6,
82.3, 84.9, 103.7, 118.6, 140.1, 153.9, 167.9, 169.6, 171.1, 178.9, 203.7

I-30

MS (FAB): 854+ (M + H +). HRMS (FAB): calcd for C46H68N3O12 854.4803 found 854.4810
IR (CHCl3): 3428, 3350, 2970, 2934, 2870, 2780, 1805, 1751, 1714, 1661, 1537, 1507,
1454, 1381, 1361, 1345, 1322, 1304, 1282, 1256, 1232, 1222, 1165, 1138, 1107, 1078,
1047, 1004, 990, 950, 930, 907, 855, 817, 666, 625, 559, 544, 532, 520, 516, 510 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 12.9, 14.2, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.1,
30.7, 33.1, 33.3, 38.0, 38.9, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.2, 73.0, 76.0, 78.4, 78.7,
82.3, 84.5, 103.7, 124.9, 125.7, 126.3, 127.2, 127.4, 127.8, 131.9, 133.6, 139.0, 153.8,
162.8, 167.5, 169.2, 170.2, 203.8

I-31

MS (FAB): 808+ (M + H +). HRMS (FAB): calcd for C42H70N3O12 808.4959 found 808.4959
IR (KBr): 3437, 2972, 2936, 2879, 2836, 2785, 1812, 1752, 1717, 1673, 1533, 1456, 1380,
1362, 1323, 1304, 1283, 1257, 1233, 1219, 1166, 1141, 1109, 1078, 1048, 1004, 993, 953,
931, 892, 860, 834, 802, 773, 755, 694, 628, 531, 456, 431, 419 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.3, 15.3, 15.6, 18.9, 19.9, 21.1, 22.3, 22.5, 22.9,
25.2, 26.3, 27.3, 28.1, 28.2, 33.1, 35.2, 38.0, 38.9, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.2,
73.0, 76.1, 78.4, 78.7, 82.3, 84.5, 103.7, 121.2, 136.7, 153.8, 167.4, 169.1, 170.1, 203.9

I-32

MS (FAB): 806+ (M + H +). HRMS (FAB): calcd for C41H64N3O13 806.4439 found 806.4438
IR (KBr): 3431, 2973, 2938, 2879, 2785, 1811, 1752, 1700, 1654, 1637, 1497, 1455, 1380,
1323, 1305, 1283, 1257, 1233, 1167, 1142, 1109, 1080, 1048, 1004, 992, 953, 932, 892,
834, 773, 751, 700, 631, 558, 529, 458 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.4, 15.5, 18.7, 19.9, 21.1, 22.2, 26.3, 28.2,
33.1, 34.4, 38.0, 40.2, 47.5, 49.8, 51.0, 65.8, 69.5, 70.2, 72.3, 76.0, 78.3, 78.4, 82.3, 84.6,
103.6, 126.1, 128.3, 128.9, 137.9, 153.6, 167.5, 167.9, 169.1, 204.0

I-33

MS (FAB): 805+ (M + H +). HRMS (FAB): calcd for C41H65N4O12 805.4599 found 805.4594
IR (KBr): 3434, 2972, 2937, 2878, 2784, 1810, 1751, 1716, 1674, 1591, 1568, 1533, 1456,
1380, 1363, 1322, 1305, 1284, 1257, 1233, 1219, 1167, 1109, 1078, 1048, 1004, 993, 953,
932, 892, 835, 772, 755, 694, 628, 557, 531, 457, 403 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.3, 15.3, 15.6, 18.9, 19.9, 21.1, 22.3, 26.4, 28.3,
29.2, 33.2, 35.3, 38.1, 38.5, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 73.0, 76.1, 78.4, 78.7,
82.4, 84.6, 103.7, 121.0, 122.8, 136.3, 149.1, 153.8, 161.2, 167.4, 169.2, 170.2, 203.9

I-34

MS (FAB): 880+ (M + H +). HRMS (FAB): calcd for C48H70N3O12 880.4960 found 880.4963
IR (CHCl3): 3436, 3354, 3024, 3006, 2976, 2936, 2874, 1805, 1751, 1715, 1665, 1536,
1485, 1454, 1410, 1381, 1362, 1346, 1319, 1305, 1282, 1256, 1229, 1220, 1166, 1139,
1107, 1078, 1045, 1004, 989, 949, 906, 833, 685, 655, 521, 512 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.2, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.1,
30.8, 32.7, 33.1, 38.0, 38.8, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.2, 73.0, 76.0, 78.4, 78.6,
82.3, 84.5, 103.7, 126.8, 126.9, 127.0, 128.6, 128.7, 138.6, 140.7, 141.1, 153.8, 167.5,
169.2, 170.3, 203.8

I-35

MS (FAB): 855+ (M + H +). HRMS (FAB): calcd for C45H67N4O12 855.4755 found 855.4747
IR (KBr): 3433, 2972, 2937, 2878, 2784, 1810, 1751, 1717, 1673, 1637, 1569, 1534, 1496,
1456, 1380, 1363, 1323, 1305, 1283, 1258, 1234, 1219, 1167, 1141, 1109, 1079, 1048,
1004, 992, 953, 931, 893, 861, 835, 787, 773, 754, 682, 614, 556, 530, 480, 456 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.2,
30.4, 30.5, 33.1, 38.0, 38.8, 40.2, 47.6, 49.8, 51.0, 65.9, 69.5, 70.2, 73.0, 75.9, 78.4, 78.6,
82.3, 84.6, 103.7, 125.2, 126.4, 127.5, 128.2, 128.4, 129.0, 134.2, 146.8, 152.0, 153.8,
167.6, 169.3, 170.5, 203.8

I- 36

MS (FAB): 818+ (M + H +). HRMS (FAB): calcd for C43H68N3O12 818.4803 found 818.4809
IR (KBr): 3438, 3061, 2974, 2938, 2878, 2785, 1812, 1752, 1717, 1673, 1529, 1497, 1455,
1379, 1322, 1283, 1257, 1233, 1167, 1142, 1109, 1082, 1047, 1005, 992, 952, 932, 899,
835, 801, 773, 750, 700, 630, 573, 555, 533, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.7, 15.9, 18.9, 19.9, 21.2, 22.2, 26.2,
28.2, 30.8, 33.0, 33.2, 37.9, 39.0, 40.2, 47.7, 49.7, 51.1, 65.8, 69.5, 70.3, 76.0, 78.4, 78.5,
78.6, 82.4, 84.5, 103.7, 125.6, 128.2, 128.3, 141.7, 153.8, 166.1, 169.1, 172.0, 203.9

I-37

MS (FAB): 818+ (M + H +). HRMS (FAB): calcd for C43H68N3O12 818.4803 found 818.4803
IR (KBr): 3438, 3061, 2974, 2937, 2878, 2785, 1811, 1751, 1717, 1671, 1525, 1497, 1455,
1379, 1321, 1283, 1257, 1233, 1167, 1142, 1109, 1082, 1048, 1005, 992, 953, 932, 899,
835, 802, 773, 749, 700, 621, 573, 510, 420 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.2, 15.5, 15.7, 17.5, 18.8, 19.7, 21.2, 22.3, 26.3,
28.2, 31.1, 33.1, 38.1, 38.7, 40.2, 47.7, 49.7, 51.0, 65.8, 69.5, 70.3, 76.2, 78.3, 78.8, 79.2,
82.5, 84.5, 103.7, 125.8, 128.2, 128.3, 128.4, 141.5, 153.9, 166.5, 169.1, 172.8, 203.9

I-38

MS (FAB): 819+ (M + H +). HRMS (FAB): calcd for C42H67N4O12 819.4755 found 819.4755
IR (KBr): 3429, 2974, 2938, 2880, 2786, 1808, 1752, 1716, 1674, 1600, 1570, 1528, 1508,
1456, 1376, 1361, 1323, 1304, 1283, 1257, 1235, 1212, 1166, 1142, 1108, 1079, 1049,
1004, 992, 953, 932, 893, 860, 835, 801, 773, 749, 693, 634, 581, 551, 517, 456 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 14.3, 15.3, 15.5, 18.8, 19.9, 21.2, 22.3, 26.3, 28.3,
33.2, 36.2, 38.0, 38.1, 40.2, 47.6, 49.7, 51.0, 51.6, 65.9, 69.5, 70.3, 72.9, 76.1, 78.4, 78.6,
82.4, 84.7, 103.7, 112.4, 116.4, 129.1, 149.3, 153.8, 167.4, 169.2, 170.6, 203.9

I-39

MS (FAB): 822+ (M + H +). HRMS (FAB): calcd for C42H65F1N3O12 822.4552 found 822.4551
IR (KBr): 3435, 2973, 2938, 2878, 2785, 1811, 1751, 1717, 1673, 1601, 1533, 1509, 1456,
1380, 1362, 1323, 1304, 1283, 1257, 1220, 1166, 1142, 1109, 1078, 1048, 1004, 992, 953,
931, 892, 834, 774, 755, 696, 628, 545, 505, 456, 420 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.5, 18.9, 19.9, 21.1, 22.3, 26.3, 28.2,
31.0, 32.4, 33.2, 38.0, 38.7, 40.2, 47.6, 49.8, 51.1, 65.9, 69.6, 70.3, 73.0, 76.1, 78.5, 78.6,
82.3, 84.6, 103.8, 114.7, 115.2, 129.6, 129.8, 137.2, 137.3, 153.7, 158.8, 163.6, 167.6,
169.2, 170.3, 203.8

I-40

MS (FAB): 810+ (M + H +). HRMS (FAB): calcd for C40H64N3O12S1 810.4211 found 810.4219
IR (CHCl3): 3424, 3350, 3016, 2970, 2934, 2870, 1805, 1751, 1714, 1663, 1537, 1454,
1381, 1361, 1345, 1321, 1305, 1282, 1255, 1232, 1220, 1165, 1139, 1107, 1075, 1046,
1004, 990, 950, 696, 666, 533, 523 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 14.3, 15.3, 15.5, 18.8, 19.9, 21.1, 22.3, 26.3, 27.2,
28.6, 31.2, 33.2, 38.0, 38.5, 40.2, 47.5, 49.7, 51.0, 65.8, 69.3, 70.2, 72.9, 76.1, 78.4, 78.5,
82.3, 84.6, 103.5, 122.9, 124.3, 126.7, 144.2, 153.8, 167.6, 169.2, 170.4, 203.9

I-41

MS (FAB): 810+ (M + H +). HRMS (FAB): calcd for C40H64N3O12S1 810.4211 found 810.4219
IR (CHCl3): 3426, 3348, 2970, 2932, 2860, 2780, 1805, 1751, 1714, 1661, 1537, 1454,
1381, 1361, 1345, 1321, 1305, 1283, 1254, 1232, 1219, 1166, 1139, 1107, 1078, 1046,
1004, 990, 950, 930, 907, 859, 833, 666, 630, 560, 533, 524, 519, 511 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.6, 18.9, 19.9, 21.2, 22.3, 26.3, 27.6,
28.2, 30.0, 33.2, 38.0, 38.8, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 73.0, 76.1, 78.4, 78.6,
82.4, 84.5, 103.8, 120.2, 125.1, 128.2, 141.8, 153.8, 167.5, 169.2, 170.3, 203.9

I-42

MS (FAB): 855+ (M + H +). HRMS (FAB): calcd for C45H67N4O12 855.4755 found 855.4762
IR (CHCl3): 3426, 3350, 2970, 2934, 2870, 1805, 1751, 1714, 1663, 1600, 1535, 1503,
1455, 1425, 1381, 1361, 1345, 1322, 1305, 1282, 1256, 1231, 1165, 1139, 1107, 1078,
1046, 1004, 990, 950, 891, 828, 665, 512 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.3, 15.4, 15.5, 18.9, 19.9, 21.1, 22.3, 26.4, 28.2,
29.3, 33.2, 36.3, 38.1, 38.8, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 73.0, 76.2, 78.4, 78.7,
82.4, 84.6, 103.7, 121.4, 125.6, 126.8, 127.4, 128.9, 129.2, 136.3, 147.9, 153.9, 161.8,
167.4, 169.1, 170.2, 203.9

I-43

MS (FAB): 855+ (M + H +). HRMS (FAB): calcd for C45H67N4O12 855.4755 found 855.4751
IR (CHCl3): 3424, 3348, 2970, 2934, 2870, 1805, 1751, 1714, 1665, 1623, 1558, 1535,
1502, 1454, 1381, 1360, 1344, 1321, 1304, 1282, 1253, 1232, 1220, 1165, 1139, 1107,
1076, 1046, 1004, 990, 950, 931, 887, 823, 666, 532, 518, 513, 509 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.3, 15.4, 15.6, 18.9, 19.9, 21.1, 22.3, 26.4, 28.2,
28.7, 32.2, 33.3, 38.2, 38.7, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 73.1, 76.2, 78.4, 78.8,
82.4, 84.6, 103.7, 119.2, 125.2, 126.9, 127.1, 127.3, 129.8, 136.2, 141.7, 153.9, 161.0,
167.3, 169.1, 170.1, 203.9

I-44

MS (FAB): 855+ (M + H +). HRMS (FAB): calcd for C45H67N4O12 855.4755 found 855.4757
IR (CHCl3): 3436, 3357, 3022, 2976, 2940, 2879, 2838, 2788, 1807, 1752, 1716, 1665,
1624, 1602, 1586, 1536, 1504, 1455, 1382, 1362, 1347, 1323, 1306, 1284, 1256, 1232,
1218, 1211, 1167, 1141, 1108, 1074, 1048, 1005, 991, 952, 931, 895, 860, 834 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.3, 26.3, 27.5,
28.2, 30.2, 33.2, 38.0, 39.1, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 73.0, 76.0, 78.4, 78.6,
82.3, 84.6, 103.8, 122.9, 126.7, 128.2, 128.4, 130.2, 130.7, 134.6, 142.4, 151.3, 153.7,
167.5, 169.2, 170.4, 203.8

I-45

MS (FAB): 855+ (M + H +). HRMS (FAB): calcd for C45H67N4O12 855.4755 found 855.4746
IR (CHCl3): 3436, 3356, 3023, 3018, 2976, 2940, 2879, 2838, 2788, 1807, 1752, 1716,
1663, 1614, 1597, 1574, 1537, 1504, 1455, 1382, 1363, 1347, 1323, 1306, 1284, 1256,
1234, 1225, 1221, 1213, 1167, 1141, 1108, 1074, 1048, 1005, 991, 952, 931, 893, 861,
833, 804 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.2, 15.3, 15.5, 18.8, 19.9, 21.1, 22.2, 26.3, 28.2,
29.5, 30.3, 33.1, 38.0, 39.0, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 73.0, 76.0, 78.4, 78.6,
82.3, 84.6, 103.7, 120.7, 126.2, 126.9, 127.9, 129.1, 132.2, 138.1, 148.7, 149.8, 153.7,
167.6, 169.2, 170.4, 203.8

I-46

MS (FAB): 832+ (M + H +). HRMS (FAB): calcd for C44H70N3O12 832.4960 found 832.4946
IR (KBr): 3443, 3062, 2975, 2938, 2878, 2785, 1812, 1751, 1717, 1669, 1525, 1498, 1455,
1378, 1362, 1323, 1305, 1284, 1258, 1218, 1166, 1109, 1083, 1047, 1005, 992, 954, 930,
835, 801, 771, 750, 699, 580, 558, 457 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 14.3, 15.3, 15.6, 18.8, 19.7, 21.2, 22.3, 24.3, 25.2,
26.2, 28.2, 31.0, 33.2, 37.9, 38.9, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 76.1, 78.4, 78.5,
82.5, 82.7, 84.5, 103.7, 125.6, 128.2, 128.4, 141.8, 153.8, 166.0, 169.2, 174.8, 204.0

I-47

MS (SI): 859+ (M + H +). HRMS (SI): calcd for C45H71N4O12 859.5065.found 859.5065.
IR (KBr): 3433, 2971, 2936, 2877, 2784, 1811, 1751, 1717, 1673, 1637, 1587, 1560, 1540,
1534, 1509, 1498, 1456, 1408, 1380, 1362, 1322, 1304, 1283, 1257, 1233, 1166, 1141,
1109, 1078, 1048, 1004, 993, 953, 931, 891, 859, 835, 802, 774, 754, 694, 669, 626, 532,
458, 425 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.5, 18.8, 19.9, 21.1, 22.2, 22.7, 22.8,
25.2, 26.3, 28.2, 28.6, 29.2, 33.0, 33.1, 38.0, 39.1, 40.2, 47.6, 49.8, 51.0, 65.9, 69.5, 70.3,
73.0, 76.0, 78.4, 78.6, 82.3, 84.6, 103.7, 121.0, 130.6, 146.2, 148.9, 153.7, 156.8, 167.6,
169.3, 170.5, 203.8

I-48

MS (SI): 904+ (M + H +). HRMS (SI): calcd for C50H70N3O12 904.4956.found904.4957.
IR (KBr): 3434, 3078, 2971, 2936, 2877, 2785, 1810, 1751, 1717, 1671, 1654, 1646, 1636,
1628, 1577, 1569, 1559, 1540, 1533, 1508, 1497, 1490, 1456, 1379, 1362, 1321, 1304,
1283, 1256, 1234, 1167, 1109, 1077, 1048, 1004, 993, 953, 931, 891, 834, 770, 749, 727,
669, 616, 558, 457, 433, 414 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.4, 15.5, 18.9, 19.9, 21.1, 22.3, 26.4, 28.2,
29.6, 30.5, 33.2, 38.0, 39.2, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 73.1, 76.1, 78.4, 78.7,
82.3, 84.6, 103.7, 122.3, 123.1, 124.3, 125.8, 126.0, 126.1, 126.4, 126.5, 128.2, 129.6,
130.6, 131.2, 131.9, 135.6, 153.8, 167.4, 169.1, 170.3, 203.9

I-49

MS (FAB): 811+ (M + H +). HRMS (FAB): calcd for C39H63N4O12S1 811.4163 found 811.4166
IR (KBr): 3433, 3080, 2973, 2938, 2878, 2784, 1809, 1751, 1716, 1673, 1533, 1504, 1455,
1380, 1363, 1323, 1305, 1284, 1257, 1233, 1168, 1141, 1109, 1078, 1047, 1004, 992, 953,
931, 892, 860, 835, 800, 772, 754, 695, 666, 628, 559, 531, 456 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.3, 26.4, 28.2,
29.5, 30.4, 33.2, 38.0, 38.2, 40.2, 47.6, 49.7, 51.0, 65.8, 69.5, 70.3, 72.9, 76.1, 78.4, 78.6,
82.4, 84.6, 103.7, 118.1, 142.2, 153.8, 167.6, 169.2, 170.1, 170.4, 203.9

I-50

MS (FAB): 861+ (M + H +). HRMS (FAB): calcd for C43H65N4O12S 1 861.4320 found 861.4329
IR (CHCl3): 3424, 3348, 2970, 2934, 2870, 2830, 1805, 1751, 1714, 1665, 1536, 1454,
1381, 1361, 1345, 1306, 1282, 1232, 1220, 1165, 1139, 1107, 1075, 1046, 1004, 990, 950,
931, 891, 665, 626, 568, 554, 550, 541, 535, 529, 526, 519, 513 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.5, 18.9, 19.9, 21.1, 22.3, 26.4, 28.2,
29.1, 31.5, 33.2, 38.0, 38.3, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 72.9, 76.1, 78.4, 78.6,
82.3, 84.6, 103.7, 121.5, 122.5, 124.5, 125.7, 135.2, 153.2, 153.8, 167.6, 169.2, 170.4,
171.1, 203.9

I-51

MS (FAB): 818+ (M + H +). HRMS (FAB): calcd for C43H68N3O12 818.4803 found 818.4805
IR (KBr): 3427, 3061, 2972, 2938, 2878, 2785, 1812, 1752, 1717, 1671, 1604, 1526, 1496,
1455, 1380, 1362, 1324, 1304, 1283, 1257, 1233, 1219, 1167, 1142, 1109, 1078, 1047,
1005, 992, 953, 932, 892, 859, 835, 801, 773, 750, 700, 628, 556, 515, 457 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.2, 15.4, 15.6, 15.7, 18.9, 19.0, 19.9, 20.7, 20.8,
21.1, 22.3, 26.4, 26.5, 28.2, 32.5, 32.6, 33.2, 38.1, 38.2, 38.3, 38.5, 40.2, 44.8, 47.6, 47.7,
49.9, 50.0, 51.1, 65.9, 69.5, 70.3, 72.9, 73.0, 76.2, 76.3, 78.4, 78.9, 79.0, 82.3, 82.4, 84.5,
103.8, 125.6, 125.7, 128.2, 128.3, 128.4, 141.7, 141.9, 153.8, 153.9, 167.9, 168.0, 169.2,
169.5, 203.8, 203.9

I-52

MS (FAB): 820+ (M + H +). HRMS (FAB): calcd for C42H66N3O13 820.4596 found 820.4603
IR (KBr): 3433, 3086, 3062, 2973, 2937, 2879, 2786, 1810, 1751, 1717, 1670, 1534, 1497,
1455, 1380, 1323, 1305, 1283, 1257, 1234, 1167, 1142, 1109, 1078, 1048, 1004, 993, 953,
932, 891, 859, 835, 774, 748, 701, 630, 556, 455, 404 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.3, 14.4, 15.3, 15.7, 18.8, 18.9, 19.8, 21.1, 22.3,
22.4, 26.5, 26.6, 28.2, 33.8, 38.1, 40.2, 41.6, 41.7, 44.6, 44.7, 47.6, 49.7, 49.8, 51.1, 51.2,
65.7, 65.8, 69.5, 70.3, 71.7, 71.8, 72.8, 76.1, 78.5, 78.6, 78.8, 78.9, 82.1, 82.3, 84.9, 85.0,
103.7, 103.8, 126.3, 128.4, 129.3, 129.4, 137.9, 154.0, 154.1, 167.5, 167.7, 169.2, 170.9,
203.8, 203.9

I-53

MS (FAB): 832+ (M + H +). HRMS (FAB): calcd for C44H70N3O12 832.4959 found 832.4952
IR (KBr): 3442, 3060, 3025, 2971, 2937, 2877, 2785, 1812, 1752, 1717, 1683, 1636, 1533,
1495, 1455, 1381, 1363, 1324, 1304, 1283, 1257, 1233, 1218, 1167, 1141, 1109, 1078,
1048, 1004, 992, 953, 932, 892, 859, 835, 800, 774, 754, 728, 703, 669, 631, 555, 529,
456, 433 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.6, 13.4, 14.6, 15.9, 16.0, 19.3, 20.3, 21.5, 22.7, 24.9, 26.9,
28.5, 33.6, 36.0, 38.5, 40.5, 46.5, 48.0, 49.3, 50.1, 51.4, 66.2, 69.8, 70.6, 73.3, 76.6, 78.7,
79.3, 82.7, 84.8, 104.2, 126.3, 128.1, 130.8, 138.4, 154.2, 168.4, 169.4, 170.5, 204.2

I-54

MS (FAB): 862+ (M + H +). HRMS (FAB): calcd for C44H68N3O14 862.4701 found 862.4709
IR (KBr): 3437, 3061, 2973, 2937, 2881, 2785, 1811, 1751, 1716, 1684, 1637, 1529, 1496,
1455, 1380, 1361, 1323, 1304, 1283, 1257, 1232, 1219, 1168, 1142, 1109, 1078, 1047,
1004, 993, 952, 933, 892, 858, 835, 800, 773, 753, 701, 669, 634, 554, 440, 411, 403 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.3, 15.4, 15.5, 18.9, 19.9, 21.2, 22.4, 26.5, 28.2,
33.3, 38.2, 40.2, 42.0, 44.2, 47.6, 49.8, 51.1, 65.5, 65.6, 65.9, 69.5, 70.3, 72.9, 76.3, 78.3,
78.9, 82.4, 84.5, 103.8, 109.3, 126.4, 127.9, 130.7, 135.7, 154.0, 168.0, 169.1, 170.1,
203.9

I-55

MS (SI): 818+ (M + H +). HRMS (SI): calcd for C42H64N3O13 818.4436 found 818.4442
IR (KBr): 3429, 2972, 2935, 2879, 2853, 2785, 1869, 1809, 1751, 1719, 1676, 1654, 1646,
1637, 1629, 1577, 1569, 1560, 1541, 1523, 1509, 1498, 1456, 1379, 1362, 1323, 1283,
1257, 1233, 1167, 1109, 1078, 1048, 1004, 993, 953, 932, 892, 859, 834, 799, 774, 754,
701, 669, 555, 477, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.3, 15.3, 15.7, 18.8, 19.8, 21.1, 22.4, 26.6, 28.3,
29.7, 38.3, 40.2, 47.6, 47.7, 48.2, 49.8, 51.1, 65.9, 69.5, 70.3, 72.6, 76.3, 78.4, 79.0, 82.4,
84.7, 103.8, 127.4, 128.9, 129.4, 133.0, 154.1, 167.7, 169.1, 170.4, 202.4, 204.0

I-56

MS (FAB): 782+ (M + H +). HRMS (FAB): calcd for C40H68N3O12 782.4803 found 782.4793
IR (KBr): 3441, 2972, 2930, 2852, 2785, 1813, 1752, 1717, 1676, 1534, 1455, 1380, 1362,
1323, 1304, 1283, 1258, 1233, 1219, 1167, 1109, 1078, 1048, 1004, 992, 953, 932, 892,
860, 835, 801, 773, 755, 694, 631, 568, 530, 457 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.3, 15.4, 15.6, 18.9, 19.9, 21.2, 22.4, 25.7, 25.8,
26.4, 26.5, 28.2, 30.8, 30.9, 33.2, 37.7, 38.1, 40.2, 45.4, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3,
73.0, 76.3, 78.4, 78.8, 82.4, 84.5, 103.8, 153.9, 167.7, 169.2, 170.2, 203.9

I-57

MS (FAB): 818+ (M + H +). HRMS (FAB): calcd for C43H68N3O12 818.4803 found 818.4805
IR (KBr): 3447, 3060, 2972, 2937, 2878, 2785, 1809, 1752, 1717, 1653, 1560, 1541, 1495,
1455, 1380, 1361, 1323, 1304, 1283, 1258, 1233, 1219, 1167, 1142, 1109, 1079, 1048,
1005, 992, 953, 932, 893, 861, 834, 800, 776, 751, 700, 622, 580, 564, 512, 490, 457,
434 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.3, 15.4, 15.5, 15.8, 18.8, 18.9, 21.2, 22.4, 26.5,
28.2, 28.6, 29.6, 29.8, 32.7, 33.1, 33.2, 34.6, 38.3, 40.2, 47.5, 47.8, 48.7, 49.7, 51.0, 65.9,
69.5, 70.3, 70.9, 71.4, 76.3, 78.5, 79.4, 82.7, 84.7, 84.8, 103.8, 125.8, 126.1, 128.3, 128.4,
128.5, 140.9, 141.7, 154.4, 165.7, 165.8, 168.7, 168.8, 169.1, 204.0

I-58

MS (FAB): 872+ (M + H +). HRMS (FAB): calcd for C42H64Cl2N3O12 872.3867 found 872.3873
IR (KBr): 3434, 2973, 2938, 2878, 2785, 1811, 1751, 1717, 1673, 1593, 1534, 1456, 1380,
1362, 1323, 1304, 1283, 1258, 1234, 1219, 1167, 1141, 1109, 1078, 1048, 1004, 992, 953,
931, 890, 859, 832, 773, 754, 684, 664, 628, 580, 532, 458, 440 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.2,
30.5, 32.3, 33.1, 38.0, 38.7, 40.2, 47.6, 49.8, 51.1, 65.9, 69.6, 70.3, 73.0, 76.0, 78.5, 78.6,
82.3, 84.6, 103.8, 127.9, 129.6, 130.2, 130.4, 132.1, 142.0, 153.8, 167.7, 169.3, 170.5,
203.9

I-59

MS (FAB): 855+ (M + H +). HRMS (FAB): calcd for C45H67N4O12 855.4755 found 855.4760
IR (KBr): 3433, 2973, 2938, 2877, 2784, 1809, 1751, 1716, 1672, 1621, 1589, 1534, 1490,
1456, 1380, 1322, 1305, 1283, 1234, 1219, 1167, 1142, 1109, 1078, 1047, 1004, 992, 953,
931, 892, 859, 827, 807, 756, 694, 665, 629, 579, 531, 513, 471 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.3,
29.4, 30.0, 33.1, 38.0, 38.9, 40.2, 47.6, 49.8, 51.0, 65.9, 69.5, 70.3, 73.0, 76.0, 78.4, 78.6,
82.3, 84.6, 103.8, 126.0, 127.0, 129.9, 134.5, 137.0, 143.0, 153.1, 153.8, 158.9, 167.6,
169.3, 170.5, 203.9

I-60

MS (FAB): 845+ (M + H +). HRMS (FAB): calcd for C42H65N6O12 845.4660 found 845.4668
IR (KBr): 3428, 2973, 2938, 2878, 2785, 1809, 1751, 1716, 1669, 1585, 1534, 1456, 1417,
1380, 1321, 1304, 1282, 1234, 1167, 1142, 1109, 1078, 1048, 1005, 993, 953, 931, 893,
859, 821, 774, 755, 682, 628, 614, 559, 454, 434 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.3, 15.3, 15.5, 18.8, 19.9, 21.2, 22.2, 25.7, 26.4,
28.2, 28.3, 33.2, 37.8, 37.9, 40.2, 47.6, 49.8, 51.0, 65.9, 69.6, 70.3, 72.6, 75.9, 78.4, 78.6,
82.6, 85.0, 103.8, 141.4, 154.2, 157.0, 158.9, 168.4, 169.5, 172.1, 203.8

I-61

MS (FAB): 855+ (M + H +). HRMS (FAB): calcd for C45H67N4O12 855.4755 found 855.4744
IR (KBr): 3433, 3055, 2973, 2937, 2878, 2784, 1809, 1751, 1716, 1672, 1630, 1591, 1533,
1491, 1455, 1381, 1362, 1323, 1305, 1283, 1257, 1234, 1219, 1167, 1141, 1109, 1078,
1048, 1005, 992, 952, 931, 890, 859, 835, 801, 754, 695, 665, 629, 557, 531, 514,
473 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.3, 15.3, 15.6, 18.9, 19.9, 21.1, 22.3, 26.4, 28.2,
29.4, 33.2, 35.1, 38.1, 38.6, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 73.0, 76.1, 78.4, 78.7,
82.4, 84.6, 103.8, 118.2, 126.2, 126.4, 127.1, 127.4, 130.2, 136.5, 151.9, 153.9, 154.5,
167.5, 169.2, 170.2, 203.9
I-62

MS (FAB): 855+ (M + H +). HRMS (FAB): calcd for C45H67N4O12 855.4755 found 855.4749
IR (KBr): 3433, 2973, 2937, 2878, 2784, 1809, 1751, 1716, 1672, 1594, 1569, 1534, 1501,
1455, 1380, 1322, 1305, 1284, 1257, 1233, 1219, 1167, 1142, 1109, 1079, 1048, 1004,
992, 953, 931, 892, 835, 800, 772, 754, 694, 666, 617, 555, 533, 480, 456 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 12.9, 14.3, 15.3, 15.6, 18.8, 19.9, 21.1, 22.2, 26.3, 28.2,
30.6, 33.1, 38.0, 38.9, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 73.0, 76.0, 78.4, 78.6, 82.4,
84.6, 103.8, 120.9, 126.2, 128.3, 129.2, 131.0, 135.8, 140.1, 147.1, 149.5, 153.8, 167.6,
169.3, 170.4, 203.9

I-63

MS (FAB): 840+ (M + H +). HRMS (FAB): calcd for C45H66N3O12 840.4647 found 840.4650
IR (KBr): 3432, 3051, 2973, 2937, 2878, 2784, 1811, 1751, 1717, 1676, 1637, 1601, 1529,
1509, 1456, 1380, 1362, 1324, 1304, 1282, 1258, 1233, 1219, 1167, 1142, 1109, 1078,
1048, 1004, 992, 953, 931, 892, 858, 817, 773, 749, 694, 622, 555, 532, 477 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.1, 15.1, 15.5, 18.4, 19.7, 21.0, 22.1, 26.2, 28.0,
33.0, 35.6, 37.9, 39.9, 40.0, 47.5, 49.6, 50.9, 65.7, 69.4, 70.2, 72.8, 76.0, 78.2, 78.7, 82.2,
84.5, 103.6, 125.2, 125.8, 126.9, 127.1, 127.4, 127.5, 128.0, 132.1, 133.4, 136.3, 153.8,
167.3, 169.1, 170.1, 203.8

I-64

MS (FAB): 856+ (M + H +). HRMS (FAB): calcd for C44H66N5O12 856.4708 found 856.4705
IR (CHCl3): 3430, 3352, 3026, 2976, 2938, 2876, 1805, 1751, 1715, 1663, 1616, 1558,
1533, 1496, 1455, 1381, 1361, 1321, 1304, 1282, 1256, 1230, 1220, 1165, 1139, 1106,
1075, 1046, 1003, 989, 950, 930, 891, 655 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.3, 15.3, 15.5, 18.9, 19.9, 21.1, 22.3, 26.4, 27.8,
28.6, 31.5, 33.2, 38.0, 38.7, 40.2, 47.6, 49.8, 51.1, 66.0, 69.3, 70.2, 73.0, 76.1, 78.4, 78.6,
82.4, 84.6, 103.6, 124.0, 124.7, 127.6, 129.0, 133.5, 149.8, 153.9, 154.5, 167.6, 169.2,
170.5, 170.7, 204.0

I-65

MS (FAB): 869+ (M + H +). HRMS (FAB): calcd for C46H69N4O12 869.4912 found 869.4922
IR (KBr): 3437, 2974, 2937, 2878, 2785, 1810, 1751, 1716, 1672, 1618, 1600, 1560, 1529,
1505, 1455, 1428, 1379, 1321, 1284, 1257, 1233, 1167, 1141, 1109, 1081, 1047, 1005,
992, 952, 931, 898, 831, 802, 754, 693, 665, 619, 573, 555, 526, 478, 455, 430 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.6, 16.0, 18.9, 19.9, 21.1, 22.3, 26.3,
28.3, 29.3, 33.1, 36.5, 38.0, 39.1, 40.2, 47.7, 49.8, 51.1, 65.9, 69.5, 70.3, 76.1, 78.5, 78.6,
82.5, 84.6, 103.7, 121.5, 125.6, 126.8, 127.4, 128.9, 129.2, 136.2, 147.9, 153.9, 162.1,
166.2, 169.2, 172.1, 203.9

I-66

MS (FAB): 869+ (M + H +). HRMS (FAB): calcd for C46H69N4O12 869.4912 found 869.4914
IR (KBr): 3435, 2974, 2938, 2878, 2784, 1810, 1751, 1717, 1673, 1591, 1569, 1528, 1509,
1456, 1379, 1322, 1284, 1257, 1235, 1167, 1142, 1109, 1082, 1047, 1005, 992, 952, 931,
902, 835, 813, 801, 757, 694, 665, 631, 573, 532, 454, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.3, 15.2, 15.7, 15.8, 18.8, 19.9, 21.1, 22.2, 26.2,
28.3, 29.2, 33.0, 37.9, 39.1, 40.2, 47.7, 49.7, 51.0, 65.8, 69.5, 70.3, 75.9, 78.3, 78.5, 82.4,
84.7, 103.7, 120.6, 123.6, 126.3, 127.6, 128.9, 130.0, 147.8, 148.2, 150.2, 153.8, 166.3,
169.3, 172.3, 203.8

I-67

MS (FAB): 869+ (M + H +). HRMS (FAB): calcd for C46H69N4O12 869.4912 found 869.4906
IR (KBr): 3436, 2974, 2938, 2877, 2784, 1810, 1751, 1717, 1672, 1623, 1583, 1528, 1456,
1379, 1322, 1283, 1257, 1233, 1167, 1109, 1082, 1047, 1005, 992, 952, 931, 896, 862,
835, 786, 753, 694, 665, 620, 559, 533, 458, 428 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.7, 15.9, 18.9, 19.9, 21.1, 22.3, 26.2,
27.6, 28.2, 30.3, 33.1, 37.9, 39.3, 40.2, 47.7, 49.8, 51.1, 65.9, 69.6, 70.3, 76.0, 78.5, 78.6,
82.4, 84.6, 103.8, 123.0, 126.7, 128.2, 128.4, 130.2, 130.9, 134.7, 142.5, 151.3, 153.8,
166.2, 169.3, 172.2, 203.9
I-68

MS (FAB): 840+ (M + H +). HRMS (FAB): calcd for C45H66N3O12 840.4647 found 840.4650
IR (KBr): 3432, 3046, 2972, 2937, 2878, 2784, 1811, 1751, 1717, 1676, 1596, 1529, 1456,
1380, 1362, 1323, 1304, 1283, 1257, 1234, 1219, 1167, 1142, 1109, 1078, 1048, 1004,
992, 953, 932, 893, 860, 834, 800, 778, 755, 694, 628, 554, 531, 456, 427 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 14.3, 15.3, 15.5, 18.8, 19.8, 21.2, 22.3, 26.3, 28.2,
32.9, 33.2, 38.0, 40.0, 40.2, 47.6, 49.7, 51.1, 65.9, 69.5, 70.3, 73.0, 76.1, 78.4, 78.6, 82.4,
84.6, 103.7, 123.9, 125.5, 125.6, 126.1, 126.6, 127.1, 128.6, 132.1, 133.8, 135.2, 153.9,
158.8, 167.4, 169.2, 170.4, 204.0

I-69

MS (FAB): 818+ (M + H +). HRMS (FAB): calcd for C43H68N3O12 818.4803 found 818.4799
IR (KBr): 3437, 3061, 2971, 2936, 2877, 2785, 1811, 1752, 1717, 1676, 1603, 1534, 1496,
1455, 1380, 1362, 1323, 1304, 1283, 1258, 1233, 1219, 1167, 1142, 1109, 1078, 1048,
1004, 992, 953, 932, 892, 859, 835, 801, 773, 742, 701, 669, 631, 555, 531, 457, 404 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.3, 15.4, 15.6, 17.4, 17.5, 18.9, 19.9, 21.1, 22.3,
26.4, 28.2, 33.2, 35.2, 35.3, 38.1, 40.2, 40.9, 41.0, 44.8, 47.6, 47.7, 49.7, 51.1, 65.8, 69.5,
70.3, 73.0, 76.2, 78.4, 78.7, 78.8, 82.4, 84.5, 103.8, 125.8, 128.2, 129.1, 140.3, 153.8,
167.7, 169.2, 170.3, 203.9

I-70

MS (FAB): 819+ (M + H +). HRMS (FAB): calcd for C42H67N4O12 819.4755 found 819.4762
IR (KBr): 3432, 3062, 2972, 2937, 2878, 2786, 1811, 1751, 1686, 1654, 1647, 1637, 1629,
1559, 1541, 1523, 1508, 1497, 1456, 1380, 1362, 1323, 1304, 1283, 1257, 1233, 1219,
1167, 1142, 1109, 1079, 1048, 1004, 993, 953, 932, 892, 859, 834, 800, 773, 751, 700,
669, 629, 555, 515, 454 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.3, 15.4, 15.6, 18.9, 19.9, 21.1, 22.3, 26.4, 28.2,
29.7, 33.1, 34.0, 38.1, 40.2, 46.4, 47.6, 50.0, 51.0, 60.9, 65.9, 69.5, 70.3, 72.6, 76.1, 78.4,
78.9, 82.4, 84.5, 103.8, 125.9, 128.3, 128.7, 139.8, 153.9, 168.3, 168.6, 169.2, 203.9

I-71

MS (FAB): 855+ (M + H +). HRMS (FAB): calcd for C45H67N4O12 855.4755 found 855.4766
IR (KBr): 3434, 2973, 2937, 2878, 2784, 1810, 1751, 1716, 1672, 1625, 1596, 1534, 1503,
1455, 1380, 1363, 1320, 1284, 1257, 1233, 1219, 1167, 1142, 1109, 1079, 1047, 1004,
992, 953, 931, 892, 835, 801, 772, 754, 695, 664, 615, 555, 530, 479, 456 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.5, 18.9, 19.9, 21.1, 22.3, 26.3, 28.2,
30.7, 33.2, 33.4, 33.4, 38.0, 38.8, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 73.0, 76.1, 78.4,
78.7, 82.3, 84.6, 103.7, 120.3, 126.7, 127.6, 127.8, 128.0, 135.6, 143.4, 148.5, 150.2,
153.8, 167.6, 169.2, 170.3, 203.9

I-72

MS (FAB): 856+ (M + H +). HRMS (FAB): calcd for C44H66N5O12 856.4708 found 856.4714
IR (KBr): 3433, 3063, 2972, 2937, 2878, 2784, 1810, 1751, 1716, 1673, 1533, 1491, 1455,
1380, 1363, 1322, 1304, 1284, 1258, 1233, 1219, 1167, 1141, 1109, 1078, 1048, 1005,
992, 953, 931, 893, 859, 835, 801, 762, 695, 666, 628, 611, 557, 532, 456, 409 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.4, 15.5, 18.9, 19.9, 21.1, 22.3, 26.3, 28.2,
28.6, 33.2, 33.5, 38.0, 38.7, 40.2, 47.6, 49.8, 51.0, 65.9, 69.5, 70.3, 73.0, 76.0, 78.4, 78.7,
82.3, 84.6, 103.8, 128.8, 129.0, 129.1, 129.7, 141.3, 142.1, 145.8, 153.8, 156.6, 167.6,
169.2, 170.4, 203.8

I-73

MS (FAB): 832+ (M + H +). HRMS (FAB): calcd for C44H70N3O12 832.4960 found 832.4955
IR (KBr): 3437, 3085, 3061, 2972, 2937, 2878, 2785, 1811, 1751, 1717, 1673, 1527, 1497,
1455, 1380, 1362, 1324, 1304, 1283, 1257, 1233, 1167, 1141, 1109, 1081, 1048, 1005,
990, 954, 932, 912, 863, 835, 801, 771, 750, 700, 669, 631, 575, 555, 533, 455, 430 (cm-1)
13C-NMR (CDCl3): δ (ppm) 9.6, 10.2, 12.9, 14.3, 15.3, 15.6, 19.0, 19.9, 21.2, 22.3, 23.6, 26.4,
28.2, 30.9, 33.2, 37.9, 38.9, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 76.1, 78.5, 82.3, 83.5,
84.5, 103.7, 125.6, 128.2, 128.4, 141.7, 153.8, 166.6, 169.2, 171.6, 204.0

I-74

MS (FAB): 832+ (M + H +). HRMS (FAB): calcd for C44H70N3O12 832.4959 found 832.4951
IR (KBr): 3439, 3061, 2972, 2937, 2878, 2785, 1811, 1751, 1717, 1671, 1604, 1577, 1525,
1497, 1455, 1380, 1362, 1323, 1305, 1283, 1258, 1233, 1219, 1167, 1142, 1109, 1082,
1048, 1005, 990, 954, 932, 904, 862, 835, 800, 777, 749, 700, 669, 632, 574, 555, 513,
457 (cm-1)
13C-NMR (CDCl3): δ (ppm) 9.9, 10.3, 12.9, 14.2, 15.4, 15.6, 18.9, 19.8, 21.1, 22.3, 25.1, 26.3,
28.2, 31.1, 33.1, 33.3, 38.1, 38.7, 40.2, 47.6, 49.7, 51.0, 65.8, 69.5, 70.3, 76.1, 78.3, 78.8,
82.4, 84.5, 84.6, 103.7, 125.7, 128.3, 128.4, 141.6, 153.8, 166.7, 169.1, 172.6, 203.9

I-75

MS (SI): 830+ (M + H +). HRMS (SI): calcd for C44H68N3O12 830.4799 found 830.4801
IR (KBr): 3434, 3060, 2972, 2937, 2878, 2785, 1809, 1751, 1699, 1654, 1646, 1637, 1604,
1496, 1455, 1380, 1362, 1322, 1303, 1284, 1257, 1233, 1219, 1167, 1109, 1083, 1047,
1005, 991, 953, 931, 901, 835, 776, 750, 700, 669, 619, 580, 528, 490, 458, 433, 413 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.4, 12.9, 14.3, 15.4, 15.7, 18.9, 19.9, 21.2, 22.4, 25.0, 26.2,
28.2, 28.5, 33.1, 33.3, 38.1, 40.2, 42.8, 45.6, 47.7, 49.8, 51.1, 65.9, 69.5, 70.3, 76.3, 78.5,
78.9, 79.4, 82.7, 84.6, 103.8, 125.8, 128.3, 128.4, 141.6, 154.3, 166.0, 169.2, 171.8, 204.1

I-76

MS (FAB): 804+ (M + H +). HRMS (FAB): calcd for C43H70N3O11 804.5010 found 804.5004
IR (KBr): 3434, 3084, 3061, 3024, 2973, 2937, 2875, 2784, 1810, 1745, 1701, 1654, 1646,
1636, 1603, 1496, 1455, 1403, 1377, 1354, 1335, 1301, 1282, 1257, 1171, 1109, 1083,
1051, 1034, 986, 958, 937, 915, 900, 835, 748, 719, 701, 669, 619, 582, 489 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.6, 14.1, 14.5, 14.9, 16.2, 18.6, 19.6, 21.2, 21.6, 24.9, 25.6,
26.4, 26.5, 28.3, 28.7, 33.1, 33.2, 33.3, 37.8, 40.2, 42.6, 42.7, 44.0, 44.1, 46.4, 49.9, 50.0,
50.9, 65.9, 69.4, 70.0, 70.2, 70.3, 73.8, 73.9, 77.6, 77.8, 78.1, 78.2, 78.9, 79.7, 103.4,
126.0, 128.3, 128.4, 141.3, 141.4, 169.4, 170.7, 170.9, 171.0, 171.1, 205.6

I-77

MS (SI): 869+ (M + H +). HRMS (SI): calcd for C46H69N4O12 869.4908 found 869.4911
IR (KBr): 3430, 2973, 2935, 2879, 1805, 1749, 1641, 1457, 1378, 1307, 1257, 1166, 1110,
1078, 1051, 998, 954, 890, 833, 769, 692, 566, 453, 412 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.3, 15.4, 15.5, 15.7, 18.8, 18.9, 19.8, 21.2, 22.4,
26.4, 27.1, 28.3, 28.6, 28.9, 29.2, 33.1, 33.5, 34.8, 38.3, 40.2, 47.6, 47.8, 49.2, 49.7, 51.1,
65.9, 69.5, 70.3, 70.9, 71.2, 76.3, 78.5, 79.3, 82.7, 84.7, 103.8, 120.6, 120.7, 123.2, 123.4,
126.4, 126.6, 127.3, 127.5, 129.0, 129.2, 130.2, 130.3, 147.0, 147.6, 148.3, 148.4, 150.3,
154.4, 165.9, 166.0, 168.9, 169.0, 169.1, 169.2, 203.9

I-78

MS (FAB): 869+ (M + H +). HRMS (FAB): calcd for C46H69N4O12 869.4912 found 869.4921
IR (KBr): 3436, 2974, 2937, 2878, 2784, 1810, 1751, 1716, 1672, 1625, 1596, 1529, 1503,
1455, 1379, 1320, 1284, 1257, 1234, 1167, 1142, 1109, 1082, 1047, 1005, 992, 952, 931,
897, 835, 801, 772, 754, 694, 663, 615, 573, 555, 530, 479, 456 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.6, 16.0, 18.9, 19.9, 21.1, 22.3, 26.3,
28.2, 30.6, 33.1, 33.5, 37.9, 39.0, 40.2, 47.6, 49.8, 51.1, 65.8, 69.5, 70.3, 76.0, 78.5, 78.6,
82.5, 84.6, 103.7, 120.3, 126.7, 127.6, 127.9, 128.0, 135.7, 143.6, 148.5, 150.2, 153.9,
166.3, 169.2, 172.1, 203.9

I-79

MS (FAB): 870+ (M + H +). HRMS (FAB): calcd for C45H68N5O12 870.4865 found 870.4869
IR (KBr): 3434, 2973, 2936, 2878, 2785, 1811, 1751, 1716, 1673, 1617, 1568, 1558, 1529,
1497, 1455, 1380, 1322, 1283, 1257, 1234, 1167, 1109, 1082, 1047, 1005, 992, 952, 932,
899, 835, 770, 693, 680, 624, 573, 512, 459 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.6, 15.9, 18.9, 19.9, 21.1, 22.3, 26.2,
27.9, 28.4, 31.7, 33.1, 37.9, 39.0, 40.1, 47.6, 49.8, 51.1, 65.9, 69.4, 70.3, 76.0, 78.5, 78.6,
82.5, 84.6, 103.7, 124.0, 124.8, 127.5, 129.0, 133.4, 149.7, 153.8, 154.5, 166.3, 169.2,
170.9, 172.3, 203.9

I-80

MS (FAB): 870+ (M + H +). HRMS (FAB): calcd for C45H68N5O12 870.4864 found 870.4874
IR (KBr): 3435, 3062, 2974, 2937, 2878, 2784, 1811, 1751, 1716, 1672, 1530, 1492, 1455,
1410, 1364, 1322, 1284, 1257, 1234, 1167, 1141, 1109, 1082, 1047, 1005, 992, 952, 931,
899, 835, 801, 762, 694, 665, 631, 610, 573, 556, 532, 457, 409 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 12.8, 14.3, 15.3, 15.6, 15.8, 18.8, 19.9, 21.1, 22.2, 26.2,
28.3, 28.6, 33.0, 33.7, 37.9, 38.9, 40.2, 47.6, 49.8, 51.0, 65.8, 69.4, 70.3, 75.9, 78.4, 78.5,
78.6, 82.4, 84.6, 103.7, 128.7, 129.0, 129.1, 129.7, 141.2, 142.2, 145.9, 153.8, 156.8,
166.3, 169.2, 172.2, 203.8

I-81

MS (SI): 883+ (M + H +). HRMS (SI): calcd for C47H71N4O12 883.5065 found 883.5069
IR (KBr): 3435, 2971, 2937, 2877, 2784, 1810, 1751, 1716, 1673, 1592, 1569, 1526, 1509,
1456, 1380, 1362, 1323, 1305, 1284, 1257, 1233, 1167, 1141, 1109, 1082, 1047, 1005,
990, 954, 932, 912, 835, 813, 800, 764, 694, 631, 574, 515, 454, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 9.8, 10.3, 12.8, 14.3, 15.2, 15.6, 18.9, 19.9, 21.1, 22.2, 23.5, 26.3,
28.2, 29.3, 29.4, 33.1, 37.8, 39.0, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 76.0, 78.5, 78.6,
82.3, 83.4, 84.6, 103.7, 120.6, 123.6, 126.3, 127.6, 128.9, 130.1, 147.8, 148.2, 150.3,
153.9, 166.8, 169.3, 171.9, 203.9

I-82

MS (SI): 883+ (M + H +). HRMS (SI): calcd for C47H73N4O12 883.5065 found 883.5068
IR (KBr): 3437, 2971, 2937, 2877, 2784, 1810, 1751, 1716, 1673, 1625, 1596, 1526, 1504,
1455, 1380, 1363, 1321, 1284, 1257, 1232, 1167, 1142, 1109, 1081, 1047, 1005, 990, 953,
932, 912, 835, 801, 772, 693, 660, 633, 615, 574, 555, 531, 478, 457 (cm-1)
13C-NMR (CDCl3): δ (ppm) 9.7, 10.2, 12.9, 14.3, 15.3, 15.6, 19.0, 19.9, 21.1, 22.3, 23.7, 26.4,
28.3, 30.8, 33.2, 33.5, 37.9, 38.9, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 76.1, 78.5, 78.6,
82.3, 83.5, 84.6, 103.8, 120.3, 126.7, 127.6, 127.9, 128.1, 135.7, 143.6, 148.6, 150.2,
153.9, 166.7, 169.3, 171.7, 204.0

I-83

MS (FAB): 846+ (M + H +). HRMS (FAB): calcd for C45H72N3O12 846.5116 found 846.5109
IR (KBr): 3436, 3061, 2965, 2930, 2874, 2854, 2785, 1810, 1750, 1717, 1671, 1527, 1496,
1455, 1381, 1323, 1304, 1284, 1257, 1233, 1219, 1167, 1141, 1109, 1079, 1047, 1007,
992, 954, 931, 913, 862, 835, 800, 777, 750, 699, 668, 577, 529, 456, 419 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.3, 15.2, 15.4, 17.0, 19.0, 19.5, 19.9, 21.2, 22.4,
26.5, 28.4, 29.5, 29.7, 31.2, 33.2, 37.9, 38.9, 40.2, 47.5, 49.8, 51.2, 66.0, 69.5, 70.3, 76.3,
78.3, 78.6, 82.2, 84.6, 87.2, 103.6, 125.7, 128.3, 128.4, 141.7, 153.9, 166.9, 169.2, 171.6,
204.1

I-84

MS (FAB): 846+ (M + H +). HRMS (FAB): calcd for C45H72N3O12 846.5116 found 846.5114
IR (KBr): 3438, 3061, 2970, 2936, 2875, 1811, 1751, 1717, 1670, 1524, 1497, 1455, 1381,
1323, 1305, 1283, 1257, 1233, 1219, 1167, 1142, 1109, 1079, 1048, 1006, 992, 954, 931,
910, 862, 835, 800, 776, 750, 700, 633, 579, 555, 513, 456 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.3, 15.4, 15.5, 18.4, 18.8, 19.0, 19.9, 21.2, 22.4,
26.3, 28.3, 30.4, 31.2, 33.3, 33.4, 38.2, 38.7, 40.2, 47.6, 49.8, 51.1, 66.0, 69.5, 70.4, 76.2,
78.4, 78.8, 82.4, 84.6, 89.0, 103.8, 125.8, 128.3, 128.4, 141.7, 153.9, 166.2, 169.2, 172.0,
203.9

I-85

MS (FAB): 862+ (M + H +). HRMS (FAB): calcd for C44H68N3O14 862.4701 found 862.4702
IR (KBr): 3435, 2973, 2937, 2877, 2784, 1811, 1751, 1717, 1674, 1590, 1532, 1508, 1456,
1380, 1362, 1305, 1285, 1259, 1238, 1219, 1205, 1167, 1109, 1071, 1048, 1004, 993, 953,
931, 917, 887, 834, 809, 773, 754, 694, 627, 554, 458, 419 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.3, 15.4, 15.5, 18.9, 19.9, 21.2, 22.3, 26.4, 28.3,
31.0, 32.4, 33.3, 38.1, 38.7, 40.2, 47.6, 49.8, 51.1, 64.3, 64.4, 65.9, 69.6, 70.4, 73.1, 76.2,
78.5, 78.7, 82.4, 84.6, 103.8, 117.0, 117.1, 121.2, 134.9, 141.7, 143.3, 153.8, 167.5, 169.2,
170.2, 204.0

I-86

MS (FAB): 848+ (M + H +). HRMS (FAB): calcd for C43H66N3O14 848.4545 found 848.4553
IR (KBr): 3434, 2972, 2937, 2879, 2784, 1811, 1751, 1716, 1673, 1533, 1504, 1489, 1455,
1380, 1363, 1323, 1304, 1283, 1244, 1167, 1141, 1109, 1078, 1046, 1004, 993, 953, 930,
893, 859, 834, 808, 773, 755,682, 630, 556, 531, 454, 426 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.3, 15.4, 15.5, 18.9, 19.9, 21.2, 22.4, 26.4, 28.3,
31.2, 32.9, 33.3, 38.1, 38.7, 40.2, 47.6, 49.8, 51.1, 66.0, 69.6, 70.4, 73.1, 76.2, 78.5, 78.7,
82.4, 84.6, 100.6, 103.8, 108.1, 108.9, 121.1, 135.5, 145.6, 147.6, 153.8, 167.6, 169.3,
170.3, 203.9

I-87

MS (FAB): 886+ (M + H +). HRMS (FAB): calcd for C45H68N5O13 886.4814 found 886.4812
IR (KBr): 3435, 3069, 2974, 2937, 2879, 2786, 1810, 1751, 1681, 1616, 1533, 1489, 1456,
1380, 1325, 1283, 1249, 1234, 1166, 1109, 1081, 1047, 1005, 993, 952, 931, 916, 899,
837, 799, 775, 754, 682, 630, 581, 534, 512, 458, 428, 406 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.7, 15.9, 18.8, 19.9, 21.1, 22.2, 26.2,
28.5, 30.7, 33.0, 37.9, 38.9, 40.0, 47.7, 49.8, 51.1, 65.8, 69.3, 70.3, 76.0, 78.4, 78.5, 78.6,
82.5, 84.7, 103.6, 122.4, 125.3, 127.5, 135.5, 141.5, 143.4, 147.3, 153.9, 163.0, 166.4,
169.3, 172.3, 203.9

I-88

MS (SI): 901+ (M + H +). HRMS (SI): calcd for C46H69N4O14 901.4806 found 901.4811
IR (KBr): 3437, 2974, 2938, 2878, 2785, 1812, 1751, 1714, 1675, 1621, 1529, 1455, 1380,
1323, 1283, 1253, 1234, 1220, 1167, 1141, 1109, 1082, 1047, 1006, 993, 952, 931, 902,
835, 774, 743, 691, 607, 558, 529, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.3, 15.3, 15.7, 15.8, 18.9, 19.9, 21.2, 22.2, 23.8,
26.2, 28.2, 30.6, 33.0, 33.6, 37.9, 38.7, 40.2, 47.7, 49.8, 51.1, 65.9, 69.6, 70.3, 75.9, 78.3,
78.5, 78.6, 82.4, 84.6, 103.8, 123.1, 123.2, 129.9, 132.6, 133.9, 149.3, 153.8, 166.3, 168.6,
169.3, 172.2, 203.8

I-89

MS (SI): 884+ (M + H +). HRMS (SI): calcd for C46H70N5O12 884.5017 found 884.5020
IR (KBr): 3435, 2971, 2937, 2878, 2784, 1810, 1751, 1717, 1671, 1637, 1527, 1499, 1456,
1379, 1324, 1304, 1284, 1257, 1233, 1218, 1167, 1140, 1109, 1080, 1048, 1005, 990, 956,
931, 912, 866, 831, 772, 755, 693, 557, 459, 407 (cm-1)
13C-NMR (CDCl3): δ (ppm) 9.8, 10.2, 12.9, 14.3, 15.3, 15.6, 15.7, 18.9, 19.9, 21.2, 22.2, 23.6,
26.4, 28.2, 30.6, 33.1, 33.4, 37.8, 38.8, 40.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 76.0, 78.5,
82.3, 83.4, 84.6, 84.7, 103.8, 127.8, 129.1, 131.7, 141.8, 143.2, 144.1, 144.5, 144.8, 153.8,
153.9, 166.8, 169.3, 171.9, 204.0

I-90

MS (FAB): 886+ (M + H +). HRMS (FAB): calcd for C45H68N5O13 886.4814 found 886.4807
IR (KBr): 3435, 2974, 2938, 2879, 2786, 1811, 1751, 1676, 1622, 1528, 1456, 1379, 1322,
1284, 1257, 1234, 1166, 1142, 1109, 1081, 1047, 1005, 992, 951, 902, 834, 773, 682, 609,
574, 506, 472, 429, 404 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.2, 15.3, 15.7, 16.0, 18.8, 19.9, 21.1, 22.2, 26.2,
28.2, 30.3, 33.0, 33.1, 37.9, 38.9, 40.2, 47.9, 49.9, 51.2, 65.8, 69.5, 70.3, 76.1, 78.3, 78.5,
82.5, 84.7, 103.7, 114.9, 125.0, 129.1, 131.2, 131.6, 145.9, 149.7, 153.9, 156.3, 166.4,
169.8, 172.3, 203.7

I-91

MS (SI): 930+ (M + H +). HRMS (SI): calcd for C47H72N5O14 9305071 found 930.5068
IR (KBr): 3437, 2974, 2937, 2878, 2784, 1809, 1751, 1716, 1670, 1638, 1612, 1530, 1498,
1455, 1362, 1323, 1284, 1258, 1234, 1167, 1140, 1109, 1082, 1047, 1005, 993, 952, 931,
901, 835, 754, 725, 682, 616, 573, 555, 513, 435 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.7, 15.8, 18.9, 19.9, 21.2, 22.2, 26.2,
28.2, 30.6, 33.0, 33.1, 33.2, 33.4, 37.9, 38.8, 40.2, 47.7, 49.8, 51.1, 65.9, 69.5, 70.3, 76.0,
78.4, 78.5, 78.6, 82.4, 84.6, 103.7, 126.7, 127.0, 127.7, 128.8, 133.8, 148.3, 153.8, 158.0,
166.3, 169.3, 172.2, 203.9

I-92

MS (FAB): 870+ (M + H +). HRMS (FAB): calcd for C45H68N5O12 870.4864 found 870.4877
IR (CHCl3): 3422, 3348, 3020, 2972, 2934, 2870, 1804, 1750, 1714, 1661, 1573, 1534,
1495, 1454, 1379, 1309, 1283, 1255, 1233, 1219, 1165, 1107, 1082, 1045, 1006, 990, 949,
930, 909, 838, 664, 560, 529, 508, 501 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.3, 15.3, 15.6, 15.7, 18.9, 19.9, 21.2, 22.2, 26.2,
28.3, 30.4, 33.0, 33.3, 37.9, 39.0, 40.2, 47.7, 49.8, 51.1, 65.9, 69.5, 70.3, 75.9, 78.3, 78.5,
78.6, 82.5, 84.7, 103.7, 125.2, 125.4, 128.1, 136.0, 142.2, 148.9, 153.9, 154.6, 159.9,
166.3, 169.4, 172.3, 203.8

I-93

MS (SI): 872+ (M + H +). HRMS (SI): calcd for C44H66N5O13 872.4653 found 872.4656
IR (KBr): 3432, 2973, 2937, 2879, 2785, 1811, 1752, 1701, 1654, 1636, 1623, 1499, 1456,
1367, 1322, 1304, 1284, 1258, 1233, 1219, 1167, 1141, 1108, 1082, 1047, 1005, 992, 954,
931, 916, 893, 866, 833, 804, 774, 754, 694, 667, 630, 568, 526, 451, 408 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.0, 15.4, 15.5, 18.7, 19.8, 21.2, 22.3, 26.2,
28.3, 33.0, 34.7, 38.0, 40.2, 47.5, 49.8, 51.0, 65.9, 69.5, 70.3, 75.9, 76.0, 77.2, 78.1, 78.3,
82.5, 84.7, 103.6, 128.7, 129.2, 132.0, 141.2, 141.9, 143.1, 144.2, 144.8, 153.7, 166.7,
169.1, 169.8, 204.0

I-94

MS (SI): 862+ (M + H +). HRMS (SI): calcd for C44H68N3O14 862.4698 found 862.4699
IR (KBr): 3438, 2973, 2937, 2878, 2784, 1811, 1751, 1717, 1673, 1529, 1504, 1489, 1455,
1379, 1364, 1323, 1284, 1244, 1167, 1141, 1109, 1082, 1046, 1005, 992, 951, 933, 862,
834, 808, 773, 755, 693, 633, 573, 555, 514, 455, 418 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.4, 15.7, 15.9, 18.9, 19.9, 21.2, 22.3,
26.3, 28.2, 31.1, 33.0, 33.1, 38.0, 38.9, 40.2, 47.7, 49.8, 51.1, 65.9, 69.5, 70.3, 76.1, 78.5,
78.6, 82.5, 84.6, 100.6, 103.8, 108.0, 108.9, 121.1, 135.6, 145.5, 147.5, 153.8, 166.3,
169.2, 172.1, 203.9

I-95

MS (SI): 864+ (M + H +). HRMS (SI): calcd for C44H70N3O14 864.4853 found 864.4850
IR (KBr): 3434, 2971, 2937, 2878, 2784, 1811, 1751, 1717, 1674, 1609, 1590, 1515, 1455,
1418, 1380, 1362, 1324, 1304, 1261, 1235, 1159, 1141, 1109, 1078, 1047, 1004, 993, 953,
931, 892, 859, 835, 803, 772, 694, 630, 556, 532, 456 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.6, 18.9, 19.9, 21.1, 22.3, 26.3, 28.2,
31.1, 32.8, 33.1, 38.0, 38.8, 40.2, 47.6, 49.8, 51.0, 55.8, 55.9, 65.9, 69.5, 70.3, 73.0, 76.1,
78.4, 78.7, 82.4, 84.6, 103.8, 111.2, 111.7, 120.1, 134.3, 147.1, 148.8, 153.8, 167.6, 169.2,
170.4, 203.9

I-96

MS (FAB): 870+ (M + H +). HRMS (FAB): calcd for C45H68N5O12 870.4864 found 870.4865
IR (KBr): 3435, 2974, 2938, 2878, 2784, 1810, 1751, 1716, 1673, 1599, 1529, 1495, 1456,
1414, 1378, 1322, 1304, 1284, 1257, 1233, 1220, 1167, 1141, 1109, 1081, 1047, 1005,
992, 952, 931, 902, 856, 802, 774, 755, 693, 641, 571, 517, 482, 454, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.7, 15.9, 18.9, 19.9, 21.1, 22.3, 26.3,
28.3, 29.0, 33.1, 36.4, 37.9, 38.9, 40.2, 47.7, 49.8, 51.1, 65.9, 69.5, 70.3, 76.0, 78.5, 78.6,
82.5, 84.6, 103.7, 119.7, 125.8, 129.8, 134.7, 143.0, 153.7, 153.9, 164.1, 166.3, 169.2,
172.2, 203.9

I-97

MS (SI): 870+ (M + H +). HRMS (SI): calcd for C45H68N5O12 870.4860 found 870.4860
IR (KBr): 3434, 2973, 2937, 2877, 2784, 1809, 1750, 1717, 1673, 1636, 1625, 1577, 1559,
1527, 1489, 1456, 1380, 1324, 1304, 1283, 1257, 1233, 1166, 1109, 1081, 1047, 1005,
993, 952, 929, 833, 774, 693, 655, 630, 575, 474 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.3, 15.3, 15.6, 15.8, 18.8, 19.9, 21.2, 22.2, 26.2,
28.3, 30.3, 32.9, 33.7, 37.9, 38.9, 40.2, 47.8, 49.8, 51.1, 65.9, 69.5, 70.3, 75.9, 78.3, 78.5,
82.5, 84.7, 103.8, 124.8, 125.1, 126.1, 126.9, 134.2, 147.6, 150.7, 151.1, 153.9, 166.4,
169.4, 172.3, 203.8

I-98

MS (SI): 888+ (M + H +). HRMS (SI): calcd for C46H70N3O14 888.4854 found 888.4860
IR (KBr): 3435, 2972, 2933, 1808, 1749, 1632, 1537, 1493, 1455, 1380, 1321, 1288, 1256,
1220, 1166, 1139, 1109, 1082, 1047, 1006, 993, 952, 831, 560, 414 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.7, 15.9, 18.9, 19.9, 21.2, 22.3, 26.2,
28.3, 30.8, 32.2, 33.1, 37.8, 37.9, 38.8, 40.2, 47.7, 49.8, 51.1, 65.9, 66.9, 69.5, 70.3, 76.0,
78.4, 78.6, 82.4, 84.6, 103.7, 117.8, 121.0, 126.2, 134.9, 136.4, 153.8, 160.2, 166.2, 169.2,
172.1, 191.9, 203.9

I-99

MS (FAB): 859+ (M + H +). HRMS (FAB): calcd for C43H67N6O12 859.4817 found 859.4808
IR (KBr): 3433, 2975, 2938, 2879, 2788, 1809, 1751, 1716, 1668, 1535, 1455, 1380, 1322,
1284, 1259, 1234, 1215, 1167, 1141, 1109, 1081, 1047, 1005, 993, 952, 901, 806, 754,
694, 665, 630, 574, 533, 430, 403 (cm-1)
13C-NMR (CD3OD): δ (ppm) 10.7, 13.2, 14.7, 15.9, 16.0, 16.9, 19.0, 20.9, 21.3, 23.3, 27.6,
31.6, 32.2, 34.3, 34.4, 38.9, 40.0, 40.5, 48.8, 49.8, 50.4, 66.1, 70.0, 71.7, 77.4, 79.2, 79.4,
79.8, 84.3, 86.4, 104.7, 113.5, 116.3, 128.2, 128.7, 129.5, 129.6, 139.4, 140.4, 142.0,
155.8, 168.0, 171.0, 174.5, 206.2

I-100

MS (FAB): 858+ (M + H +). HRMS (FAB): calcd for C44H68N5O12 858.4864 found 858.4857
IR (KBr): 3433, 2975, 2937, 2879, 1807, 1750, 1670, 1577, 1455, 1381, 1321, 1285, 1237,
1164, 1140, 1110, 1082, 1047, 1005, 952, 895, 803, 774, 756, 692, 621, 572, 529,
431 (cm-1)
13C-NMR (CD3OD): δ (ppm) 10.7, 13.2, 14.7, 15.9, 16.0, 16.9, 19.0, 20.9, 21.3, 23.4, 27.7,
31.5, 32.6, 34.4, 34.5, 37.9, 39.0, 40.1, 40.4, 49.2, 50.2, 50.4, 66.3, 69.9, 71.4, 77.6, 79.2,
79.8, 84.4, 86.4, 104.6, 115.0, 116.6, 124.7, 138.0, 155.9, 168.0, 171.0, 174.4, 206.3

I-101

MS (SI): 858+ (M + H +). HRMS (SI): calcd for C45H68N3O13 858.4748 found 858.4751
IR (KBr): 3435, 2973, 2936, 2877, 2785, 1811, 1751, 1716, 1672, 1532, 1513, 1456, 1379,
1323, 1305, 1284, 1258, 1235, 1196, 1167, 1141, 1109, 1082, 1047, 1005, 992, 952, 931,
902, 885, 832, 806, 772, 737, 694, 632, 555, 532, 456, 427 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 12.9, 14.3, 15.3, 15.7, 15.9, 18.9, 19.9, 21.1, 22.3, 26.2,
28.2, 31.4, 33.1, 33.2, 37.9, 39.1, 40.2, 47.7, 49.8, 51.1, 65.9, 69.5, 70.3, 76.1, 78.4, 78.5,
78.6, 82.5, 84.5, 103.7, 106.5, 110.9, 120.5, 125.0, 127.4, 136.2, 144.8, 153.6, 153.9,
166.2, 169.2, 172.0, 203.9

I-102

MS (SI): 886+ (M + H +). HRMS (SI): calcd for C46H68N3O14 886.4698 found 886.4698
IR (KBr): 3434, 2972, 2935, 2877, 2786, 1809, 1750, 1716, 1656, 1619, 1570, 1532, 1482,
1455, 1379, 1316, 1285, 1257, 1235, 1167, 1139, 1109, 1081, 1047, 1005, 993, 952, 932,
900, 863, 833, 802, 773, 755, 693, 628, 581, 556, 518, 453 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.7, 15.9, 18.9, 19.9, 21.1, 22.3, 26.2,
28.4, 30.9, 32.6, 33.1, 37.9, 38.8, 40.2, 47.7, 49.8, 51.1, 66.0, 69.4, 70.3, 76.0, 78.5, 78.6,
82.4, 84.6, 103.7, 112.8, 118.1, 124.6, 124.7, 134.5, 139.3, 153.9, 155.1, 166.3, 169.3,
172.2, 177.7, 203.9

I-103

MS (FAB): 856+ (M + H +). HRMS (FAB): calcd for C44H66N5O12 856.4708 found 856.4716
IR (KBr): 3434, 2972, 2937, 2878, 2784, 1810, 1751, 1716, 1673, 1619, 1533, 1498, 1455,
1365, 1323, 1304, 1284, 1257, 1233, 1218, 1167, 1141, 1109, 1078, 1048, 1004, 992, 955,
931, 893, 831, 773, 755, 664, 628, 556, 513, 457, 407 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.6, 18.9, 19.9, 21.1, 22.2, 26.3, 28.2,
30.5, 33.2, 33.3, 38.0, 38.8, 40.2, 47.6, 49.8, 51.1, 65.9, 69.6, 70.3, 73.0, 76.0, 78.5, 78.6,
82.3, 84.6, 103.8, 127.8, 129.2, 131.6, 141.8, 143.2, 144.1, 144.4, 144.8, 153.8, 167.7,
169.3, 170.5, 203.9

I-104

MS (SI): 870+ (M + H +). HRMS (SI): calcd for C45H68N5O12 870.4861 found 870.4863
IR (KBr): 3436, 2974, 2937, 2878, 2784, 1810, 1751, 1716, 1671, 1620, 1529, 1499, 1455,
1367, 1321, 1284, 1257, 1233, 1218, 1167, 1141, 1109, 1082, 1047, 1005, 992, 954, 931,
897, 866, 832, 773, 755, 694, 664, 631, 572, 512, 456, 432, 408 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.3, 15.5, 15.6, 17.6, 18.8, 19.8, 21.2, 22.3, 26.3,
28.3, 30.7, 33.3, 38.1, 38.6, 40.2, 47.7, 49.7, 51.1, 65.9, 69.5, 70.3, 76.2, 78.4, 78.8, 79.2,
82.5, 84.6, 103.8, 127.8, 129.2, 131.7, 141.8, 143.2, 144.2, 144.4, 144.9, 154.0, 166.9,
169.2, 173.1, 203.9

I-105

MS (SI): 870+ (M + H +). HRMS (SI): calcd for C45H68N5O12 870.4861 found 870.4862
IR (KBr): 3435, 2972, 2937, 2878, 2784, 1808, 1751, 1716, 1651, 1541, 1498, 1455, 1379,
1323, 1305, 1284, 1257, 1233, 1218, 1167, 1141, 1109, 1078, 1048, 1005, 993, 955, 931,
894, 866, 832, 777, 755, 692, 666, 623, 582, 564, 514, 456, 408 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.3, 15.4, 15.5, 15.7, 18.8, 18.9, 19.8, 21.2, 22.4,
26.5, 28.2, 32.9, 33.2, 33.4, 34.8, 38.3, 40.2, 47.5, 47.8, 49.0, 49.6, 49.7, 51.1, 65.9, 69.5,
70.3, 70.9, 71.2, 76.3, 78.5, 79.3, 82.7, 84.7, 103.8, 127.7, 127.8, 129.3, 1296, 131.4,
131.6, 141.8, 141.9, 143.7, 144.2, 144.4, 144.5, 144.9, 145.1, 154.4, 165.9, 166.0, 168.9,
169.0, 169.1, 204.0

I-106

MS (SI): 884+ (M + H +). HRMS (SI): calcd for C46H70N5O12 884.5016 found 884.5015
IR (KBr): 3443, 2974, 2937, 2878, 2785, 1808, 1752, 1716, 1651, 1498, 1455, 1369, 1322,
1305, 1284, 1257, 1233, 1219, 1167, 1141, 1109, 1082, 1047, 1005, 993, 955, 931, 895,
866, 831, 775, 692, 665, 621, 512, 453, 407 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 10.4, 13.0, 14.2, 15.5, 15.9, 16.5, 16.7, 18.8, 18.9, 19.9,
21.1, 21.2, 22.4, 22.5, 25.9, 26.0, 28.1, 28.3, 30.3, 33.0, 33.3, 34.0, 35.6, 38.1, 40.2, 47.9,
49.3, 49.4, 49.5, 51.1, 65.9, 69.4, 70.4, 73.5, 73.8, 76.1, 76.2, 78.4, 79.1, 82.5, 84.5, 103.7,
127.7, 127.8, 129.2, 129.3, 131.6, 141.8, 143.2, 144.1, 144.3, 144.6, 144.8, 144.9, 154.4,
164.5, 164.9, 168.9, 169.1, 171.2, 203.9

I-107

MS (FAB): 700+ (M + H +). HRMS (FAB): calcd for C34H58N3O12 700.4020 found 700.4016
IR (KBr): 3485, 2975, 2938, 2879, 2840, 2785, 1812, 1751, 1694, 1633, 1589, 1456, 1380,
1322, 1284, 1257, 1233, 1219, 1167, 1142, 1110, 1082, 1047, 1005, 992, 951, 894, 862,
835, 801, 774, 755, 693, 625, 530 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.4, 12.9, 14.3, 15.3, 15.5, 15.8, 18.9, 19.9, 21.2, 22.4, 26.2,
28.3, 33.1, 37.9, 40.2, 47.5, 49.7, 51.1, 65.9, 69.5, 70.3, 76.2, 78.2, 78.3, 78.5, 82.5, 84.7,
103.7, 154.0,166.4, 169.3, 174.7, 204.1

I-108

MS (FAB): 890+ (M + H +). HRMS (FAB): calcd for C44H68N5O12S 890.4585 found 890.4586
IR (KBr): 3435, 2974, 2937, 2877, 2784, 1750, 1716, 1673, 1620, 1528, 1499, 1455, 1376,
1322, 1279, 1257, 1217, 1162, 1143, 1107, 1078, 1051, 1032, 991, 945, 899, 866, 828,
765, 707, 684, 641, 609, 553, 512, 472, 424, 408 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 10.5, 14.3, 14.4, 14.5, 15.9, 16.5, 19.1, 19.9, 21.0, 21.2,
22.1, 22.4, 26.2, 28.3, 30.9, 31.0, 32.6, 33.3, 33.4, 33.5, 37.7, 38.2, 38.8, 39.0, 40.2, 47.1,
47.9, 49.9, 51.1, 51.3, 65.0, 65.9, 69.5, 70.3, 76.5, 77.2, 77.9, 78.3, 78.4, 78.6, 78.8, 90.5,
90.6, 103.5, 103.9, 127.8, 127.9, 129.1, 129.3, 131.6, 131.8, 141.8, 143.2, 144.0, 144.2,
144.3, 144.6, 144.7, 144.9, 166.6, 166.9, 169.2, 169.3, 171.1, 172.7, 172.8, 203.9

I-109

MS (FAB): 844+ (M + H +). HRMS (FAB): calcd for C44H70N5O11 844.5072 found 844.5065
IR (CHCl3): 3422, 2972, 2932, 2868, 2828, 1740, 1711, 1669, 1523, 1499, 1453, 1403,
1375, 1333, 1279, 1255, 1219, 1175, 1140, 1107, 1082, 1049, 1031, 983, 955, 906, 864,
786, 667, 558, 541, 533, 529, 522, 518, 510, 505 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.5, 13.6, 14.7, 14.9, 16.3, 17.5, 18.9, 19.8, 21.2, 21.5, 26.6,
28.5, 30.9, 33.3, 33.4, 37.5, 38.7, 40.2, 45.9, 50.0, 50.9, 66.0, 69.3, 70.2, 70.3, 73.8, 78.3,
78.4, 79.1, 103.2, 127.9, 129.2, 131.6, 141.8, 143.1, 144.2, 144.3, 144.9, 169.7, 172.4,
172.9, 205.9

I-110

MS (SI): 872+ (M + H +). HRMS (SI): calcd for C44H66N5O13 872.4653 found 872.4649
IR (KBr): 3439, 2974, 2937, 2879, 2784, 1810, 1751, 1716, 1680, 1609, 1575, 1524, 1495,
1457, 1378, 1360, 1322, 1299, 1261, 1223, 1164, 1141, 1107, 1083, 1047, 1005, 992, 952,
931, 895, 862, 830, 801, 757, 728, 693, 631, 573, 555, 514, 456, 432 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.5, 16.0, 18.8, 19.8, 21.2, 22.2, 26.3,
28.2, 33.1, 37.9, 38.1, 40.2, 47.5, 49.8, 51.0, 65.9, 67.3, 69.5, 70.3, 75.9, 78.3, 78.4, 82.4,
84.7, 103.7, 109.7, 121.3, 130.3, 135.4, 143.4, 144.0, 145.1, 153.9, 154.3, 166.5, 169.0,
172.8, 204.0

I-111

MS (FAB): 858+ (M + H +). HRMS (FAB): calcd for C45H72N5O11 858.5228 found 858.5220
Anal Calcd for C45H67N5O12 (H2O) 0.6: C 62.21, H 8.38, N 8.06 Found C 62.25, H 8.29, N
7.98
IR (KBr): 3433, 2971, 2937, 2876, 2837, 2784, 1744, 1712, 1682, 1619, 1527, 1498, 1455,
1377, 1336, 1300, 1259, 1181, 1107, 1093, 1075, 988, 957, 938, 891, 870, 833, 799, 697,
665, 632, 617, 583, 555, 510, 408 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.5, 14.3, 14.5, 14.9, 15.9, 19.6, 20.6, 21.2, 22.2, 27.9, 28.2,
29.2, 31.0, 33.1, 37.8, 38.4, 40.2, 46.9, 50.1, 51.4, 53.5, 53.9, 61.4, 65.9, 69.5. 70.2, 72.7,
77.8, 79.0, 80.3, 80.8, 104.1, 127.7, 129.3, 131.5, 141.8, 143.1, 144.0, 144.3, 145.0, 169.2,
170.2, 170.7, 204.0

I-112

MS (FAB): 819+ (M + H +). HRMS (FAB): calcd for C42H67N4O12 819.4755 found 819.4755
IR (KBr): 3437, 3061, 2974, 2938, 2878, 2785, 1811, 1751, 1716, 1672, 1496, 1455, 1379,
1322, 1283, 1257, 1233, 1166, 1141, 1110, 1082, 1047, 1005, 992, 953, 930, 916, 892,
835, 801, 774, 749, 700, 631, 572, 555, 532, 457, 432, 404 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.3, 15.4, 16.1, 18.9, 19.9, 21.2, 22.4, 26.3, 28.2,
33.2, 34.5, 38.0, 40.2, 47.5, 49.8, 51.1, 53.0, 65.9, 69.6, 70.3, 76.2, 77.9, 78.2, 78.4, 82.5,
84.5, 103.7, 126.0, 128.3, 128.7, 139.7, 153.9, 166.6, 169.1, 171.2, 204.2

I-113

MS (SI): 833+ (M + H +). HRMS (SI): calcd for C43H69N4O12 833.4907 found 833.4901
IR (KBr): 3433, 3060, 2974, 2937, 2878, 2786, 1812, 1752, 1690, 1636, 1559, 1521, 1496,
1455, 1380, 1322, 1283, 1257, 1233, 1166, 1142, 1109, 1082, 1047, 1005, 993, 953, 930,
916, 895, 835, 773, 750, 700, 631, 555, 512, 455, 414 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.3, 15.4, 15.6, 16.5, 19.0, 20.0, 21.2, 22.3, 26.4,
28.2, 33.1, 34.0, 38.0, 40.2, 46.1, 47.7, 50.1, 51.1, 60.8, 65.9, 69.6, 70.3, 76.2, 78.3, 78.4,
78.8, 82.4, 84.5, 103.8, 125.9, 128.2, 128.3, 128.8, 128.9, 139.9, 153.9, 167.4, 169.2,
170.6, 203.9

I-114

MS (FAB): 869+ (M + H +). HRMS (FAB): calcd for C46H69N4O12 869.4912 found 869.4912
IR (KBr): 3430, 3066, 2975, 2937, 2879, 2788, 1801, 1748, 1716, 1647, 1559, 1541, 1456,
1396, 1380, 1321, 1286, 1235, 1162, 1109, 1082, 1047, 1006, 993, 953, 895, 832, 773,
757, 693, 627, 573, 477, 413 (cm-1)
13C-NMR (CD3OD): δ (ppm) 10.8, 13.0, 14.7, 15.7, 16.1, 16.6, 19.0, 20.9, 21.3, 23.2, 27.7,
31.5, 32.0, 34.2, 36.4, 38.9, 40.3, 50.5, 60.4, 66.4, 69.8, 71.1, 77.2, 79.5, 79.9, 84.1, 86.7,
104.5, 127.5, 128.6, 129.2, 131.7, 132.7, 135.9, 138.5, 139.1, 151.6, 155.8, 168.4, 171.3,
175.5, 206.0

I-115

MS (FAB): 871+ (M + H +). HRMS (FAB): calcd for C45H67N4O13 871.4704 found 871.4706
IR (KBr): 3437, 2974, 2937, 2878, 2784, 1809, 1751, 1717, 1677, 1597, 1570, 1527, 1502,
1457, 1378, 1318, 1282, 1262, 1234, 1167, 1141, 1109, 1082, 1047, 1005, 993, 953, 930,
897, 824, 792, 774, 754, 730, 693, 630, 575, 534, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.2, 15.5, 16.1, 18.8, 19.8, 21.2, 22.3, 26.3,
28.2, 33.2, 37.9, 38.1, 40.2, 47.5, 49.7, 51.0, 65.9, 67.1, 69.5, 70.3, 76.0, 78.4, 78.5, 82.5,
84.7, 103.6, 109.6, 119.9, 121.5, 126.9, 129.5, 135.9, 140.3, 149.1, 154.0, 154.4, 166.2,
169.0, 172.6, 204.1

I-116

MS (FAB): 861+ (M + H +). HRMS (FAB): calcd for C45H73N4O12 861.5225 found 861.5217
IR (KBr): 3444, 3060, 2974, 2938, 2878, 2784, 1811, 1752, 1717, 1668, 1540, 1496, 1456,
1414, 1381, 1367, 1323, 1304, 1282, 1257, 1219, 1166, 1109, 1083, 1048, 1005, 993, 942,
895, 834, 801, 773, 749, 700, 618, 569, 511, 404 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.3, 15.7, 16.2, 17.0, 18.9, 20.0, 21.2, 22.5, 26.0,
28.2, 30.5, 32.9, 33.7, 38.3, 38.4, 40.2, 44.2, 44.3, 48.2, 49.6, 51.2, 65.9, 69.5, 70.4, 73.3,
76.2, 78.4, 79.6, 82.7, 84.4, 103.8, 125.7, 128.3, 128.4, 141.7, 154.3, 163.7, 168.9, 174.2,
203.9

I-117

MS (FAB): 871+ (M + H +). HRMS (FAB): calcd for C44H67N6O12 871.4817 found 871.4827
IR (KBr): 3436, 2974, 2937, 2878, 2784, 1811, 1751, 1716, 1675, 1540, 1498, 1455, 1369,
1322, 1283, 1256, 1233, 1218, 1166, 1140, 1109, 1082, 1047, 1005, 993, 955, 929, 893,
866, 833, 773, 664, 631, 514, 472, 453, 435, 408 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.3, 15.4, 15.9, 18.9, 19.9, 21.2, 22.3, 26.3, 28.2,
33.1, 34.6, 37.9, 40.2, 47.5, 49.8, 51.1, 52.5, 65.9, 69.6, 70.3, 76.2, 77.8, 78.2, 78.4, 82.5,
84.6, 103.7, 128.4, 129.2, 131.8, 141.9, 142.6, 143.2, 144.2, 144.8, 153.9, 166.7, 169.2,
171.5, 204.1

I-118

MS (FAB): 871+ (M + H +). HRMS (FAB): calcd for C45H67N4O13 871.4704 found 871.4709
IR (KBr): 3441, 3068, 2974, 2938, 2879, 2784, 1811, 1751, 1716, 1681, 1619, 1590, 1575,
1525, 1457, 1408, 1380, 1317, 1265, 1234, 1201, 1168, 1143, 1108, 1083, 1047, 1005,
992, 952, 931, 897, 834, 800, 774, 742, 693, 616, 573, 512, 454 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.3, 15.3, 15.6, 15.7, 18.8, 19.8, 21.2, 22.2, 26.2,
28.2, 33.1, 37.9, 38.6, 40.2, 47.7, 49.7, 51.0, 65.9, 67.0, 69.5, 70.3, 75.9, 78.3, 78.5, 82.4,
84.7, 103.8, 105.3, 120.2, 121.6, 129.4, 131.2, 149.1, 150.5, 153.9, 154.3, 166.3, 169.3,
172.6, 203.9

I-119

MS (FAB): 886+ (M + H +). HRMS (FAB): calcd for C45H68N5O13 886.4814 found 886.4821
IR (KBr): 3445, 2974, 2937, 2878, 2784, 1808, 1752, 1717, 1654, 1609, 1575, 1493, 1457,
1404, 1359, 1323, 1299, 1261, 1222, 1164, 1107, 1083, 1047, 1005, 992, 951, 895, 862,
830, 757, 728, 691, 621, 530, 512, 452, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 13.0, 14.2, 15.4, 15.6, 16.0, 16.4, 16.5, 18.7, 18.8,
19.9, 21.2, 22.3, 22.4, 25.8, 26.0, 28.2, 32.9, 34.3, 37.3, 38.1, 40.2, 47.7, 48.0, 48.8, 49.4,
49.5, 51.1, 65.9, 66.9, 69.5, 70.4, 73.4, 73.6, 76.0, 78.4, 79.1, 82.4, 82.6, 84.5, 84.7, 103.8,
109.2, 109.5, 121.1, 121.5, 128.2, 129.0, 130.2, 130.5, 143.4, 144.0, 145.1, 145.2, 154.2,
154.3, 154.4, 154.6, 164.1, 164.9, 169.1, 171.9, 172.0, 203.9, 204.0

I-120

MS (FAB): 885+ (M + H +). HRMS (FAB): calcd for C45H69N6O12 885.4973 found 885.4971
IR (KBr): 3430, 2975, 2937, 2879, 2784, 1806, 1749, 1716, 1673, 1600, 1575, 1533, 1500,
1457, 1407, 1375, 1322, 1284, 1234, 1166, 1141, 1110, 1081, 1047, 1006, 993, 950, 835,
811, 775, 755, 711, 694, 628, 572, 555, 530, 460, 435 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 12.7, 14.3, 15.2, 15.4, 15.7, 18.8, 19.9, 21.1, 22.1, 26.2,
28.3, 30.8, 32.9, 36.6, 37.8, 40.2, 45.2, 47.7, 49.7, 51.0, 65.8, 69.5, 70.3, 75.8, 78.1, 78.4,
78.6, 82.4, 84.8, 103.7, 123.4, 130.4, 132.0, 138.0, 139.0, 146.5, 147.5, 153.9, 166.5,
169.5, 172.6, 203.7

I-121

MS (FAB): 861+ (M + H +). HRMS (FAB): calcd for C42H65N6O13 861.4610 found 861.4606
IR (KBr): 3434, 3089, 2975, 2938, 2880, 2786, 1808, 1750, 1716, 1671, 1621, 1598, 1521,
1456, 1420, 1381, 1316, 1282, 1257, 1219, 1166, 1141, 1109, 1082, 1047, 1004, 993, 952,
930, 900, 860, 834, 789, 775, 742, 682, 632, 573, 457 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 12.8, 14.2, 14.7, 15.3, 15.8, 18.6, 19.9, 21.1, 22.1, 26.0,
28.3, 32.9, 37.8, 39.0, 40.2, 47.7, 49.7, 51.0, 65.8, 67.8, 69.3, 70.1, 75.6, 77.9, 78.3, 78.4,
83.1, 85.2, 103.4, 105.9, 110.7, 124.5, 128.0, 131.6, 144.9, 154.2, 165.2, 171.7, 203.2

I-122

MS (FAB): 874+ (M + H +). HRMS (FAB): calcd for C44H68N5O13 874.4814 found 874.4817
IR (KBr): 3434, 3070, 2975, 2938, 2879, 2785, 1809, 1750, 1715, 1671, 1592, 1539, 1456,
1409, 1380, 1322, 1283, 1256, 1233, 1166, 1141, 1108, 1082, 1047, 1005, 993, 952, 930,
900, 835, 783, 736, 682, 630, 574, 458 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 12.9, 14.3, 14.7, 15.4, 15.8, 18.7, 20.0, 21.2, 22.2, 26.1,
28.3, 32.9, 37.9, 39.3, 40.2, 47.8, 49.7, 51.0, 65.9, 67.4, 69.5, 70.3, 75.7, 78.1, 78.5, 78.6,
83.5, 85.3, 103.3, 103.7, 103.8, 110.9, 121.9, 145.4, 150.8, 154.6, 165.4, 169.4, 171.6,
203.7

I-123

MS (FAB): 889+ (M + H +). HRMS (FAB): calcd for C45H66F1N4O13 889.4610 found
889.4621
IR (KBr): 3436, 3072, 2974, 2938, 2879, 2785, 1810, 1751, 1717, 1678, 1631, 1599, 1571,
1526, 1474, 1457, 1400, 1378, 1317, 1283, 1258, 1236, 1168, 1142, 1109, 1082, 1048,
1005, 992, 952, 930, 899, 833, 812, 789, 753, 743, 693, 633, 559, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.5, 16.1, 18.8, 19.8, 21.2, 22.3, 26.3,
28.2, 33.1, 37.9, 38.1, 40.2, 47.5, 49.7, 51.0, 65.9, 67.5, 69.5, 70.3, 76.0, 78.3, 78.4, 78.5,
82.5, 84.7, 103.7, 108.7, 108.8, 109.5, 109.8, 119.8, 120.0, 121.6, 129.2, 129.3, 140.2,
150.0, 150.2, 150.8, 150.9, 153.4, 153.9, 166.4, 169.1, 172.7, 204.0

I-124

MS (FAB): 870+ (M + H +). HRMS (FAB): calcd for C45H68N5O12 870.4864 found 870.4867
IR (KBr): 3436, 2973, 2937, 2878, 2784, 1811, 1751, 1716, 1674, 1577, 1528, 1490, 1456,
1379, 1361, 1322, 1283, 1257, 1233, 1167, 1142, 1109, 1082, 1047, 1005, 993, 952, 931,
900, 865, 835, 801, 771, 682, 632, 573, 533, 453, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.2, 15.3, 15.7, 16.1, 18.9, 19.9, 21.1, 22.2, 26.3,
28.0, 28.2, 30.3, 33.0, 37.9, 39.0, 40.2, 47.7, 49.7, 51.0, 65.8, 69.5, 70.3, 75.9, 78.4, 78.5,
78.6, 82.4, 84.5, 103.8, 127.4, 129.3, 129.8, 141.2, 141.7, 143.1, 143.7, 144.5, 153.8,
166.3, 169.1, 172.0, 203.9

I-125

MS (FAB): 913+ (M + H +). HRMS (FAB): calcd for C47H73N6O12 913.5286 found 913.5279
IR (KBr): 3445, 2974, 2938, 2878, 2784, 1810, 1752, 1717, 1668, 1620, 1569, 1540, 1498,
1456, 1415, 1368, 1323, 1304, 1282, 1257, 1217, 1166, 1109, 1083, 1047, 1005, 992, 954,
895, 865, 831, 773, 755, 692, 617, 569, 510, 456, 434, 407 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.3, 15.7, 16.2, 16.3, 17.0, 18.9, 20.0, 21.2, 22.5,
26.0, 28.3, 30.2, 32.9, 33.9, 38.3, 38.4, 40.3, 44.3, 44.4, 48.2, 49.6, 51.2, 66.0, 69.5, 70.4,
73.3, 76.1, 78.4, 79.7, 82.7, 84.5, 103.9, 127.8, 129.3, 131.6, 141.9, 143.2, 144.1, 144.6,
144.8, 154.4, 163.8, 168.9, 174.4, 203.9

I-126

MS (FAB): 859+ (M + H +). HRMS (FAB): calcd for C43H67N6O12 859.4817 found 859.4821
IR (KBr): 3433, 3089, 3056, 2974, 2938, 2879, 2784, 1809, 1751, 1716, 1673, 1599, 1583,
1531, 1501, 1455, 1409, 1365, 1322, 1285, 1257, 1234, 1197, 1167, 1142, 1109, 1082,
1047, 1005, 993, 952, 932, 897, 835, 801, 775, 755, 682, 637, 574, 554, 512, 456,
431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.3, 15.2, 15.6, 15.9, 18.8, 19.9, 21.1, 22.2, 26.2,
28.4, 30.0, 33.0, 36.3, 37.8, 40.2, 41.3, 47.6, 49.7, 51.0, 65.8, 69.4, 70.3, 75.9, 78.3, 78.4,
78.5, 82.4, 84.7, 103.7, 117.9, 127.7, 135.4, 143.9, 144.7, 147.2, 153.8, 166.5, 169.3,
172.6, 203.8

I-127

MS (FAB): 884+ (M + H +). HRMS (FAB): calcd for C46H70N5O12 884.5021 found 884.5015
IR (KBr): 3434, 2973, 2937, 2878, 2784, 1809, 1751, 1716, 1674, 1592, 1531, 1455, 1364,
1322, 1284, 1256, 1234, 1218, 1167, 1142, 1109, 1083, 1047, 1005, 992, 952, 924, 897,
862, 835, 776, 709, 694, 620, 574, 555, 512, 455, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.3, 15.2, 15.5, 15.7, 18.8, 19.9, 21.2, 22.2, 26.2,
28.2, 31.0, 32.9, 36.9, 37.9, 40.2, 47.7, 49.7, 51.0, 65.8, 69.5, 70.3, 75.9, 78.2, 78.5, 78.6,
82.5, 84.7, 103.8, 105.9, 118.1, 121.0, 122.3, 123.4, 131.9, 146.0, 146.5, 153.9, 166.3,
169.4, 172.3, 203.8

I-128

MS (FAB): 885+ (M + H +). HRMS (FAB): calcd for C45H69N6O12 885.4973 found 885.4973
IR (KBr): 3434, 3125, 2973, 2937, 2878, 2784, 1808, 1750, 1715, 1673, 1588, 1533, 1455,
1378, 1323, 1284, 1255, 1220, 1168, 1142, 1109, 1083, 1047, 1005, 993, 952, 921, 898,
862, 833, 789, 754, 683, 652, 619, 573, 554, 513, 456, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.3, 15.2, 15.6, 15.7, 18.8, 19.9, 21.1, 22.2, 26.2,
28.2, 31.0, 32.9, 36.7, 37.8, 40.2, 47.7, 47.8, 49.7, 51.0, 65.8, 69.5, 70.3, 75.9, 78.2, 78.5,
78.6, 82.5, 84.7, 103.8, 107.0, 120.9, 121.4, 122.4, 122.7, 126.3, 148.3, 153.9, 156.8,
166.4, 169.4, 172.4, 203.8

I-129

MS (FAB): 872+ (M + H +). HRMS (FAB): calcd for C44H66N5O13 872.4657 found 872.4670
IR (KBr): 3440, 2975, 2938, 2879, 2784, 1809, 1750, 1718, 1679, 1613, 1570, 1526, 1482,
1458, 1382, 1308, 1284, 1259, 1234, 1167, 1141, 1110, 1082, 1047, 1004, 993, 952, 929,
897, 835, 767, 742, 722, 683, 652, 632, 573, 554, 467, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.3, 15.2, 15.5, 15.9, 18.8, 19.8, 21.2, 22.2, 26.3,
28.2, 33.1, 37.9, 38.0, 40.2, 47.5, 49.8, 51.0, 65.9, 67.0, 69.5, 70.3, 75.9, 78.3, 78.4, 78.5,
82.4, 84.7, 103.7, 113.6, 118.7, 126.1, 128.4, 142.2, 153.8, 153.9, 154.4, 159.9, 166.5,
169.1, 172.9, 203.9

I-130

MS (FAB): 884+ (M + H +). HRMS (FAB): calcd for C46H70N5O12 884.5021 found 884.5026
IR (KBr): 3434, 3129, 3067, 2973, 2937, 2878, 2784, 1809, 1751, 1716, 1674, 1600, 1557,
1531, 1455, 1376, 1322, 1284, 1256, 1219, 1167, 1142, 1109, 1082, 1047, 1005, 991, 952,
931, 897, 830, 782, 694, 672, 617, 573, 530, 457 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.3, 15.2, 15.5, 15.7, 18.8, 19.9, 21.1, 22.2, 26.2,
28.2, 30.9, 32.9, 36.8, 37.8, 40.2, 47.7, 47.8, 49.7, 51.0, 65.8, 69.5, 70.3, 75.8, 78.2, 78.5,
78.6, 82.5, 84.7, 103.8, 106.2, 119.4, 121.7, 122.6, 143.6, 149.8, 153.9, 166.4, 169.4,
172.4, 203.8

I-131

MS (FAB): 885+ (M + H +). HRMS (FAB): calcd for C45H69N6O12 885.4973 found 885.4976
IR (KBr): 3432, 2974, 2937, 2878, 2783, 1809, 1750, 1716, 1673, 1582, 1559, 1533, 1456,
1393, 1366, 1322, 1295, 1217, 1167, 1142, 1109, 1082, 1047, 1005, 991, 952, 937, 897,
836, 806, 774, 718, 681, 664, 619, 535, 457, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.3, 15.2, 15.5, 15.7, 18.8, 19.9, 21.2, 22.2, 26.2,
28.2, 30.9, 33.0, 36.7, 37.9, 40.2, 47.7, 47.9, 49.7, 51.1, 65.9, 69.6, 70.3, 75.9, 78.2, 78.5,
78.6, 82.4, 84.7, 103.8, 107.3, 115.5, 122.4, 122.5, 123.0, 153.9, 156.2, 158.8, 161.3,
166.4, 169.4, 172.4, 203.8

I-132

MS (FAB): 885+ (M + H +). HRMS (FAB): calcd for C45H69N6O12 885.4973 found 885.4967
IR (KBr): 3434, 3108, 3070, 2974, 2938, 2878, 2784, 1809, 1751, 1716, 1674, 1605, 1529,
1455, 1380, 1323, 1283, 1256, 1221, 1167, 1142, 1109, 1081, 1047, 1005, 991, 961, 952,
932, 896, 861, 825, 774, 755, 704, 679, 632, 573, 533, 456, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.3, 15.3, 15.7, 15.8, 18.9, 19.9, 21.2, 22.2, 26.2,
28.2, 30.2, 33.0, 36.4, 37.9, 40.2, 47.7, 49.8, 50.1, 51.1, 65.8, 69.5, 70.3, 75.9, 78.3, 78.4,
78.5, 82.5, 84.7, 103.8, 120.0, 127.9, 136.9, 140.5, 150.1, 153.9, 166.6, 169.4, 172.6,
203.8

I-133

MS (SI): 888+ (M + H +). HRMS (SI): calcd for C44H66N5O12S 888.4425 found 888.4428
IR (KBr): 3434, 2973, 2937, 2878, 2784, 1810, 1751, 1716, 1675, 1561, 1523, 1484, 1455,
1364, 1322, 1283, 1256, 1232, 1167, 1141, 1109, 1083, 1047, 1005, 984, 951, 896, 865,
827, 809, 768, 693, 630, 573, 555, 452, 423, 404 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.3, 15.3, 15.6, 15.7, 18.9, 19.9, 21.2, 22.2, 26.2,
28.2, 29.6, 33.1, 37.9, 38.4, 40.2, 47.6, 49.8, 51.0, 65.9, 69.6, 70.3, 75.9, 78.3, 78.4, 78.5,
82.4, 84.7, 103.7, 125.4, 125.5, 130.4, 138.2, 140.9, 143.2, 143.4, 145.3, 153.8, 166.4,
169.2, 172.6, 203.9

I-134

MS (FAB): 858+ (M + H +). HRMS (FAB): calcd for C44H68N5O12 858.4864 found 858.4888
IR (KBr): 3436, 3095, 3051, 2974, 2938, 2878, 2784, 1811, 1751, 1716, 1675, 1594, 1569,
1510, 1455, 1427, 1379, 1363, 1321, 1284, 1256, 1233, 1167, 1141, 1109, 1082, 1047,
1005, 992, 952, 931, 894, 862, 835, 798, 774, 722, 693, 631, 575, 513, 484, 454, 430 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.7, 16.2, 18.9, 19.9, 21.1, 22.3, 26.3,
28.1, 30.3, 33.1, 36.4, 38.0, 40.2, 41.9, 47.7, 49.7, 51.1, 65.8, 69.5, 70.3, 76.0, 78.5, 78.6,
78.7, 82.4, 84.6, 99.4, 103.7, 115.4, 120.6, 128.4, 128.6, 142.5, 147.6, 153.9, 166.3, 169.2,
172.2, 203.9

I-135

MS (FAB): 744+ (M + H +). HRMS (FAB): calcd for C36H62N3O13 744.4283 found 744.4291
IR (KBr): 3437, 2975, 2938, 2879, 2786, 1811, 1751, 1717, 1670, 1533, 1456, 1379, 1323,
1284, 1257, 1234, 1167, 1142, 1110, 1082, 1047, 1005, 992, 952, 931, 897, 834, 802, 774,
755, 693, 631, 574, 533, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.8, 14.3, 15.2, 15.8, 15.9, 18.9, 19.9, 21.2, 22.3, 26.3,
28.2, 33.3, 38.0, 40.2, 42.3, 47.7, 49.7, 51.1, 62.2, 65.9, 69.6, 70.4, 75.9, 78.4, 78.5, 78.6,
82.4, 85.1, 103.7, 154.3, 166.2, 169.3, 173.2, 203.9

I-136

MS (FAB): 716+ (M + H +). HRMS (FAB): calcd for C34H58N3O13 716.3970 found 716.3972
IR (KBr): 3433, 2976, 2938, 2880, 2787, 1812, 1751, 1715, 1676, 1456, 1379, 1322, 1284,
1257, 1234, 1167, 1142, 1109, 1081, 1047, 1006, 992, 954, 930, 917, 893, 832, 773, 754,
681, 668, 631, 571, 531, 453 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 14.3, 15.4, 15.5, 18.7, 19.9, 21.2, 22.4, 26.3, 28.3,
33.1, 37.9, 40.1, 47.4, 49.7, 51.1, 65.7, 69.4, 70.4, 76.1, 76.8, 77.9, 78.4, 82.6, 84.7, 103.6,
153.8, 166.9, 169.1, 169.4, 204.2

I-137

MS (FAB): 870+ (M + H +). HRMS (FAB): calcd for C45H68N5O12 870.4864 found 870.4869
IR (CHCl3): 3348, 3028, 2974, 2936, 2874, 1804, 1749, 1660, 1592, 1542, 1502, 1453,
1379, 1360, 1320, 1304, 1281, 1233, 1215, 1165, 1138, 1105, 1071, 1045, 1003, 989, 949,
922, 905 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.2, 15.3, 15.6, 18.8, 19.9, 21.1, 22.1, 26.2, 28.4,
31.0, 33.0, 36.6, 37.8, 40.2, 47.5, 47.6, 49.7, 50.9, 65.9, 69.2, 70.0, 72.8, 75.8, 78.3, 78.4,
82.2, 84.5, 103.4, 105.8, 117.8, 122.0, 123.2, 131.7, 145.8, 146.2, 153.5, 167.3, 169.0,
170.4, 203.4

I-138

MS (SI): 872+ (M + H +). HRMS (SI): calcd for C44H66N5O13 872.4653 found 872.4652
IR (KBr): 3437, 2974, 2937, 2879, 2784, 1811, 1751, 1716, 1668, 1603, 1590, 1557, 1525,
1456, 1378, 1364, 1308, 1283, 1256, 1234, 1219, 1166, 1143, 1109, 1082, 1047, 1005,
992, 950, 896, 863, 835, 801, 755, 693, 631, 573, 556, 534, 455, 418 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.4, 15.5, 15.6, 18.9, 19.8, 21.2, 22.3, 26.2,
28.2, 33.1, 36.3, 37.9, 40.2, 40.6, 47.6, 49.9, 51.1, 65.9, 69.5, 70.3, 76.2, 78.1, 78.4, 78.5,
82.8, 84.7, 103.7, 114.4, 123.5, 130.4, 131.2, 132.9, 133.4, 150.2, 153.9, 154.7, 166.2,
169.3, 172.9, 204.0

I-139

MS (FAB): 859+ (M + H +). HRMS (FAB): calcd for C43H67N6O12 859.4817 found 859.4823
IR (KBr): 3433, 3051, 2974, 2937, 2879, 2784, 1807, 1750, 1716, 1674, 1611, 1531, 1494,
1455, 1414, 1379, 1362, 1317, 1298, 1286, 1256, 1234, 1167, 1141, 1109, 1082, 1047,
1005, 993, 953, 931, 897, 835, 778, 683, 632, 583, 513, 456, 429 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.7, 14.3, 15.2, 15.5, 15.7, 18.7, 19.8, 21.1, 22.1, 26.2,
28.2, 29.7, 32.9, 36.5, 37.8, 40.2, 43.4, 47.7, 49.6, 51.0, 65.7, 69.5, 70.3, 75.7, 78.1, 78.4,
78.5, 82.4, 84.9, 103.7, 117.8, 118.2, 126.1, 144.5, 145.5, 153.9, 156.4, 166.5, 169.5,
172.7, 203.8

I-140

MS (FAB): 860+ (M + H +). HRMS (FAB): calcd for C42H66N7O12 860.4769 found 860.4775
IR (KBr): 3435, 3062, 2974, 2938, 2879, 2784, 1808, 1750, 1716, 1675, 1604, 1576, 1529,
1455, 1418, 1379, 1320, 1277, 1257, 1234, 1167, 1109, 1082, 1047, 1006, 993, 952, 932,
900, 862, 835, 799, 781, 692, 629, 582, 555, 513, 454 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.3, 15.2, 15.7, 18.8, 19.8, 21.1, 22.2, 26.2, 28.2,
29.6, 33.0, 36.5, 37.8, 40.2, 46.7, 47.6, 49.7, 51.0, 65.7, 69.5, 70.3, 75.9, 78.2, 78.4, 78.5,
82.4, 84.9, 103.7, 119.0, 121.9, 125.4, 148.0, 153.9, 157.5, 166.7, 169.4, 172.7, 203.9

I-141

MS (FAB): 862+ (M + H +). HRMS (FAB): calcd for C41H64N7O13 862.4562 found 862.4567
IR (KBr): 3437, 2974, 2938, 2879, 2784, 1810, 1751, 1716, 1680, 1591, 1524, 1456, 1379,
1323, 1283, 1255, 1234, 1167, 1141, 1109, 1083, 1047, 1006, 993, 952, 929, 900, 835,
804, 775, 693, 630, 574, 508, 454, 429 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.6, 16.3, 18.9, 19.9, 21.1, 22.3, 26.4,
28.1, 33.2, 37.3, 38.0, 40.2, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 76.1, 78.4, 78.5, 78.6, 79.7,
82.5, 84.6, 103.7, 120.6, 129.2, 135.0, 139.9, 151.2, 154.0, 166.5, 169.1, 172.6, 204.0

I-142

MS (FAB): 886+ (M + H +). HRMS (FAB): calcd for C45H68N5O13 886.4814 found 888.4813
IR (KBr): 3431, 2974, 2937, 2878, 2784, 1811, 1752, 1716, 1677, 1609, 1574, 1518, 1495,
1457, 1379, 1359, 1299, 1261, 1223, 1164, 1107, 1084, 1047, 1005, 992, 953, 932, 901,
862, 830, 816, 801, 757, 729, 693, 631, 574, 513, 453, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 10.3, 12.9, 13.0, 14.3, 15.4, 15.7, 16.1, 16.5, 17.5, 17.6,
19.0, 19.9, 20.0, 21.2, 22.8, 26.4, 28.2, 33.1, 38.0, 38.1, 40.2, 44.0, 44.2, 47.7, 50.1, 51.1,
65.9, 69.5, 70.3, 71.5, 71.6, 76.0, 76.1, 78.4, 78.5, 78.6, 78.7, 78.9, 82.5, 84.5, 84.6, 103.8,
110.2, 110.3, 121.2, 121.3, 130.4, 135.6, 135.7, 143.4, 144.0, 145.1, 154.0, 154.4, 167.1,
167.2, 169.1, 169.2, 172.2, 203.8

I-143

MS (FAB): 860+ (M + H +). HRMS (FAB): calcd for C42H66N7O12 860.4769 found 860.4770
IR (KBr): 3435, 2974, 2938, 2879, 2784, 1811, 1751, 1716, 1676, 1590, 1527, 1455, 1379,
1323, 1284, 1257, 1217, 1167, 1142, 1109, 1082, 1047, 1005, 992, 952, 931, 900, 862,
835, 804, 777, 755, 692, 631, 583, 555, 534, 456, 430 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.7, 15.9, 18.9, 19.9, 21.1, 22.3, 26.3,
28.2, 29.4, 33.1, 36.5, 37.9, 40.2, 44.6, 47.6, 49.8, 51.0, 65.8, 69.5, 70.3, 76.0, 78.3, 78.4,
78.5, 82.5, 84.7, 103.7, 119.6, 128.4, 136.9, 145.9, 150.0, 153.8, 166.5, 169.2, 172.3,
203.9

I-144

MS (FAB): 860+ (M + H +). HRMS (FAB): calcd for C42H66N7O12 860.4769 found 860.4773
IR (KBr): 3436, 2974, 2938, 2879, 2784, 1810, 1751, 1716, 1676, 1603, 1560, 1527, 1455,
1380, 1323, 1283, 1257, 1233, 1167, 1142, 1109, 1082, 1047, 1005, 992, 952, 931, 897,
862, 835, 805, 781, 755, 682, 631, 573, 555, 532, 456 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.7, 15.8, 18.9, 19.9, 21.1, 22.2, 26.3,
28.2, 29.7, 33.1, 36.4, 37.9, 40.2, 47.6, 49.8, 51.0, 55.0, 65.8, 69.5, 70.3, 76.0, 78.3, 78.5,
82.4, 84.7, 103.8, 121.7, 127.0, 136.4, 151.4, 153.8, 155.8, 166.6, 169.3, 172.5, 203.9

I-145

MS (FAB): 886+ (M + H +). HRMS (FAB): calcd for C45H68N5O13 886.4814 found 888.4816
IR (KBr): 3441, 2975, 2937, 2878, 2784, 1810, 1751, 1716, 1681, 1607, 1572, 1526, 1492,
1472, 1456, 1379, 1359, 1322, 1296, 1257, 1233, 1164, 1108, 1084, 1047, 1005, 992, 953,
931, 894, 863, 830, 801, 759, 728, 682, 632, 573, 555, 512, 433 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.5, 16.1, 16.4, 17.7, 17.9, 18.8, 18.9,
19.8, 19.9, 21.2, 22.3, 26.3, 26.4, 28.2, 33.1, 33.2, 37.9, 40.2, 43.8, 43.9, 47.6, 49.7, 51.0,
65.8, 69.5, 70.3, 73.9, 74.7, 76.0, 76.1, 78.4, 78.5, 78.6, 82.4, 82.5, 84.6, 84.7, 103.7,
112.3, 112.5, 121.6, 121.8, 130.1, 130.4, 136.0, 136.1, 143.4, 143.6, 144.2, 145.0, 145.1,
153.6, 153.8, 154.0, 166.2, 166.8, 169.0, 169.1, 172.6, 203.9, 204.0

I-146

MS (FAB): 860+ (M + H +). HRMS (FAB): calcd for C43H66N5O13 860.4657 found 860.4660
IR (KBr): 3433, 2974, 2938, 2879, 2786, 1809, 1751, 1716, 1672, 1632, 1591, 1513, 1455,
1379, 1311, 1283, 1254, 1236, 1166, 1141, 1108, 1083, 1047, 1005, 992, 951, 899, 862,
835, 785, 738, 683, 631, 575, 555, 454 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 12.8, 14.3, 14.9, 15.3, 15.8, 18.7, 19.9, 21.2, 22.2, 26.1,
28.2, 32.9, 37.9, 39.2, 40.2, 47.8, 49.8, 51.0, 65.8, 67.5, 69.5, 70.4, 75.7, 78.1, 78.5, 78.6,
83.3, 85.3, 103.8, 103.9, 111.7, 111.8, 122.4, 140.3, 146.3, 154.6, 165.6, 169.5, 171.9,
203.7
I-147

MS (FAB): 874+ (M + H +). HRMS (FAB): calcd for C44H68N5O13 874.4814 found 874.4808
IR (KBr): 3439, 3090, 2974, 2938, 2879, 2784, 1808, 1751, 1715, 1676, 1615, 1591, 1527,
1503, 1456, 1423, 1378, 1348, 1281, 1258, 1235, 1166, 1109, 1081, 1047, 1005, 993, 952,
931, 916, 899, 863, 835, 781, 737, 707, 684, 630, 573, 555, 512, 454 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.3, 15.2, 15.6, 16.4, 18.9, 19.8, 21.2, 22.3, 26.4,
28.2, 31.1, 33.3, 38.0, 38.6, 40.2, 47.6, 49.6, 51.0, 65.8, 67.4, 69.5, 70.3, 76.1, 78.4, 78.6,
82.5, 84.7, 102.6, 103.7, 104.7, 123.7, 134.0, 136.3, 142.1, 150.6, 154.0, 166.3, 169.0,
172.4, 204.1

I-148

MS (FAB): 874+ (M + H +). HRMS (FAB): calcd for C44H68N5O13 874.4814 found 874.4813
IR (KBr): 3437, 2974, 2938, 2879, 2784, 1809, 1751, 1716, 1677, 1620, 1589, 1528, 1503,
1456, 1417, 1375, 1324, 1286, 1262, 1234, 1169, 1141, 1109, 1084, 1047, 1005, 992, 951,
931, 900, 784, 732, 682, 642, 580, 554, 510 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.8, 14.3, 15.2, 15.6, 15.7, 18.8, 19.8, 21.2, 22.2, 26.2,
28.2, 33.0, 34.0, 37.9, 38.5, 40.2, 47.6, 49.7, 51.0, 65.8, 66.7, 69.5, 70.3, 75.9, 78.3, 78.5,
82.4, 84.7, 103.7, 104.5, 113.0, 122.4, 124.4, 143.7, 145.9, 146.7, 153.9, 166.3, 169.4,
172.4, 203.9

I- 149

MS (FAB): 920+ (M + H +). HRMS (FAB): calcd for C44H66N5O14S1 920.4327 found 920.4323
IR (KBr): 3434, 2974, 2937, 2879, 2784, 1809, 1751, 1716, 1681, 1522, 1484, 1456, 1378,
1319, 1256, 1233, 1199, 1167, 1144, 1129, 1109, 1082, 1047, 1005, 992, 952, 895, 867,
835, 774, 724, 682, 668, 647, 554, 526, 450, 421 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 14.3, 15.2, 15.6, 15.7, 18.8, 19.8, 21.2, 22.3, 26.3,
28.2, 33.1, 33.3, 37.9, 40.2, 47.6, 49.7, 51.0, 54.9, 65.8, 69.5, 70.3, 75.9, 78.0, 78.4, 78.5,
82.3, 84.7, 103.7, 129.0, 132.7, 136.0, 136.5, 139.5, 143.1, 145.7, 146.0, 153.8, 166.5,
169.2, 172.1, 204.0

I-150

MS (FAB): 904+ (M + H +). HRMS (FAB): calcd for C44H66N5O13S1 904.4378 found 904.4380
IR (KBr): 3432, 2974, 2937, 2879, 2784, 1808, 1750, 1716, 1676, 1524, 1456, 1378, 1322,
1284, 1256, 1234, 1167, 1141, 1109, 1082, 1047, 1005, 993, 974, 952, 895, 847, 834, 773,
682, 632, 574, 552, 455, 431, 405 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 14.3, 15.3, 15.7, 15.9, 16.0, 18.8, 19.9, 20.0, 21.2,
22.3, 22.4, 26.3, 28.2, 32.9, 33.1, 38.0, 40.2, 47.6, 49.7, 51.1, 52.8, 65.8, 69.5, 70.3, 75.9,
76.1, 78.2, 78.3, 78.4, 78.5, 82.4, 82.5, 84.6, 103.7, 127.3, 127.4, 129.9, 130.0, 131.6,
131.7, 138.9, 141.8, 141.9, 142.7, 142.8, 144.4, 144.5, 146.0, 153.8, 153.9, 166.3, 166.4,
169.1, 169.2, 172.2, 204.0

I-151

MS (FAB): 873+ (M + H +). HRMS (FAB): calcd for C43H65N6O13 873.4610 found 873.4613
IR (KBr): 3437, 2975, 2938, 2880, 2786, 1810, 1750, 1716, 1679, 1600, 1573, 1525, 1452,
1375, 1338, 1282, 1256, 1231, 1168, 1141, 1111, 1082, 1047, 1005, 992, 952, 932, 895,
842, 827, 774, 754, 697, 558, 462, 434 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.6, 16.0, 18.8, 19.8, 21.1, 22.3, 26.2,
28.4, 33.1, 37.9, 38.2, 40.2, 47.6, 49.8, 51.0, 65.8, 66.0, 69.4, 70.3, 76.0, 78.4, 78.5, 82.5,
84.6, 103.6, 115.9, 130.3, 144.3, 144.9, 147.9, 148.9, 153.8, 160.6, 166.2, 169.1, 172.4,
204.0

I-152

MS (FAB): 898+ (M + H +). HRMS (FAB): calcd for C47H72N5O12 898.5177 found 898.5170
IR (KBr): 3436, 2973, 2938, 2878, 2784, 1809, 1750, 1716, 1673, 1593, 1523, 1455, 1374,
1322, 1284, 1256, 1223, 1167, 1142, 1109, 1082, 1047, 1005, 992, 951, 932, 902, 862,
834, 783, 755, 709, 692, 619, 573, 555, 532, 456, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 12.8, 14.2, 15.3, 15.7, 15.8, 18.8, 19.9, 21.1, 22.2, 23.8,
26.2, 28.2, 28.3, 33.0, 33.7, 37.9, 39.2, 40.2, 47.7, 49.8, 51.0, 65.8, 69.5, 70.3, 75.9, 78.3,
78.5, 82.5, 84.6, 103.6, 103.8, 118.2, 119.4, 123.4, 131.7, 132.0, 134.5, 145.8, 146.3,
153.8, 166.3, 169.3, 172.2, 203.9

I-153

MS (FAB): 942+ (M + H +). HRMS (FAB): calcd for C49H76N5O13 942.5440 found 942.5432
IR (KBr): 3436, 2974, 2937, 2878, 2784, 1810, 1751, 1716, 1673, 1595, 1520, 1456, 1364,
1323, 1284, 1256, 1233, 1167, 1141, 1109, 1081, 1047, 1005, 992, 951, 899, 862, 834,
802, 776, 755, 717, 693, 619, 573, 533, 456, 431, 405 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 12.9, 14.3, 15.3, 15.7, 15.8, 18.9, 19.9, 21.2, 22.2, 24.1,
26.2, 28.1, 28.2, 30.4, 33.0, 37.9, 39.2, 40.2, 47.7, 49.8, 51.1, 57.5, 64.3, 65.8, 69.5, 70.3,
76.0, 78.4, 78.5, 78.6, 82.5, 84.6, 103.8, 105.0, 121.0, 123.2, 125.1, 132.8, 134.4, 135.4,
146.5, 149.2, 153.8, 166.2, 169.3, 172.2, 203.9

I-154

MS (SI): 871+ (M + H +). HRMS (SI): calcd for C44H67N6O12 871.4812 found 871.4811
IR (KBr): 3430, 3072, 2974, 2937, 2878, 2784, 1810, 1751, 1717, 1674, 1636, 1604, 1582,
1522, 1482, 1456, 1408, 1359, 1323, 1283, 1256, 1234, 1215, 1168, 1140, 1109, 1082,
1047, 1005, 993, 952, 932, 899, 864, 826, 773, 753, 693, 555, 534, 455, 434 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.8, 14.3, 15.2, 15.7, 18.8, 19.8, 21.2, 22.3, 26.2, 28.2,
33.1, 37.9, 38.4, 40.2, 43.0, 47.7, 49.8, 51.1, 65.9, 69.6, 70.4, 75.9, 78.3, 78.5, 82.4, 84.8,
103.8, 105.0, 115.0, 131.7, 133.2, 140.9, 143.9, 145.0, 145.1, 153.9, 166.3, 169.3, 172.9,
203.9

I-155

MS (FAB): 887+ (M + H +). HRMS (FAB): calcd for C44H67N6O13 887.4766 found 887.4763
IR (KBr): 3434, 3063, 2975, 2938, 2879, 2785, 1808, 1751, 1715, 1674, 1624, 1554, 1534,
1490, 1455, 1371, 1322, 1284, 1257, 1231, 1167, 1109, 1082, 1046, 1005, 992, 952, 931,
903, 834, 774, 716, 693, 630, 573, 528, 455, 428 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.6, 16.0, 18.9, 19.9, 21.2, 22.3, 26.3,
28.2, 29.2, 33.1, 36.0, 37.9, 40.2, 47.4, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 75.9, 78.4, 78.5,
82.4, 84.7, 103.7, 105.7, 137.3, 137.6, 143.8, 148.5, 149.6, 153.9, 161.2, 166.6, 169.3,
172.7, 203.9

I-156

MS (FAB): 884+ (M + H +). HRMS (FAB): calcd for C46H70N5O12 884.5021 found 884.5030
IR (KBr): 3433, 3133, 2974, 2938, 2879, 2784, 1807, 1750, 1715, 1672, 1606, 1532, 1504,
1482, 1455, 1368, 1322, 1284, 1256, 1233, 1168, 1142, 1109, 1083, 1047, 1006, 993, 951,
913, 833, 801, 776, 754, 694, 628, 573, 512, 456, 432 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 12.7, 14.3, 15.2, 15.5, 15.7, 18.8, 19.8, 21.1, 22.1, 26.2,
28.2, 30.8, 32.9, 36.6, 37.8, 40.2, 45.1, 47.7, 49.7, 51.0, 65.8, 69.5, 70.3, 75.8, 78.1, 78.4,
78.5, 82.4, 84.8, 103.8, 115.0, 124.8, 126.4, 128.4, 134.5, 137.4, 142.0, 153.9, 166.5,
169.4, 172.6, 203.8

I-157

MS (FAB): 836+ (M + H +). HRMS (FAB): calcd for C42H66N3O14 836.4545 found 836.4541
IR (KBr): 3436, 2975, 2938, 2879, 2785, 1809, 1751, 1716, 1672, 1596, 1527, 1503, 1457,
1378, 1323, 1304, 1265, 1221, 1167, 1142, 1109, 1083, 1047, 1006, 992, 952, 932, 900,
861, 835, 802, 773, 746, 693, 631, 575, 555, 517, 454 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.7, 14.3, 15.1, 15.2, 15.7, 18.7, 19.8, 21.2, 22.2, 26.1,
28.2, 33.0, 37.9, 39.1, 40.2, 47.7, 49.6, 51.0, 65.8, 68.6, 69.6, 70.4, 75.8, 78.2, 78.4, 78.5,
82.6, 85.0, 103.7, 112.3, 115.1, 119.7, 121.5, 146.4, 154.1, 165.7, 169.4, 172.6, 203.9

I-158

MS (FAB): 900+ (M + H +). HRMS (FAB): calcd for C46H70N5O13 900.4970 found 900.4978
IR (KBr): 3436, 2974, 2938, 2878, 2785, 1811, 1751, 1716, 1672, 1566, 1530, 1497, 1457,
1373, 1323, 1285, 1255, 1235, 1166, 1108, 1082, 1047, 1005, 992, 952, 932, 890, 837,
802, 774, 755, 693, 572, 532, 438 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.6, 16.0, 18.9, 19.9, 21.1, 22.2, 26.2,
27.3, 28.2, 30.2, 33.0, 37.9, 39.1, 40.2, 47.6, 49.8, 51.1, 62.8, 65.9, 69.5, 70.3, 76.0, 78.4,
78.6, 82.4, 84.6, 103.7, 124.6, 132.2, 135.0, 137.8, 142.9, 143.5, 144.0, 153.0, 153.9,
166.3, 169.2, 172.1, 203.9

I-159

MS (FAB): 906+ (M + H +). HRMS (FAB): calcd for C44H65ClN5O13 906.4267 found 906.4268
IR (KBr): 3438, 2975, 2938, 2879, 2785, 1811, 1752, 1716, 1680, 1596, 1566, 1526, 1482,
1455, 1371, 1322, 1285, 1256, 1234, 1168, 1141, 1109, 1084, 1047, 1005, 992, 952, 930,
894, 835, 774, 755, 693, 651, 573, 509, 455, 437 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.3, 15.3, 15.6, 16.7, 18.9, 19.9, 21.1, 22.4, 26.4,
28.2, 33.2, 38.0, 39.5, 40.2, 47.6, 49.7, 51.1, 65.9, 69.5, 70.3, 73.9, 76.1, 78.4, 78.7, 79.0,
82.4, 84.6, 103.7, 125.7, 127.8, 131.4, 138.3, 142.9, 144.7, 145.2, 150.8, 154.1, 166.3,
169.1, 171.9, 204.0

I-160

MS (FAB): 886+ (M + H +). HRMS (FAB): calcd for C45H68N5O13 886.4814 found 886.4805
IR (KBr): 3435, 2974, 2938, 2879, 2785, 1811, 1751, 1716, 1672, 1576, 1530, 1504, 1458,
1381, 1361, 1323, 1279, 1233, 1166, 1141, 1109, 1082, 1047, 1005, 992, 952, 901, 866,
833, 774, 755, 694, 555, 455, 437 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.3, 15.3, 15.7, 16.1, 18.9, 19.9, 21.1, 22.3, 26.3,
27.2, 28.2, 29.4, 33.1, 38.0, 38.9, 40.2, 47.7, 49.8, 51.1, 65.9, 69.5, 70.3, 76.1, 78.4, 78.5,
78.6, 82.5, 84.6, 103.7, 119.1, 124.7, 132.8, 133.3, 142.0, 142.1, 144.6, 149.0, 153.9,
166.3, 169.2, 172.1, 203.9

I-161

MS (FAB): 862+ (M + H +). HRMS (FAB): calcd for C42H64N5O14 862.4450 found 862.4441
IR (KBr): 3439, 2975, 2938, 2879, 2785, 1810, 1751, 1716, 1681, 1586, 1540, 1496, 1456,
1408, 1382, 1359, 1322, 1283, 1261, 1238, 1217, 1166, 1109, 1082, 1047, 1005, 992, 951,
930, 887, 835, 799, 781, 693, 658, 632, 577, 555, 512, 455, 430 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 12.9, 14.3, 15.3, 15.6, 15.9, 18.9, 19.8, 21.1, 22.3, 26.3,
28.2, 33.1, 37.9, 38.2, 40.2, 47.6, 49.8, 51.0, 65.8, 69.1, 69.5, 70.3, 76.1, 78.4, 78.5, 82.5,
84.6, 103.7, 117.9, 124.1, 133.2, 147.2, 153.8, 157.0, 166.0, 166.4, 169.1, 172.4, 204.0

I-162

MS (FAB): 874+ (M + H +). HRMS (FAB): calcd for C45H68N3O14 874.4701 found 874.4709
IR (KBr): 3442, 2974, 2938, 2879, 2784, 1812, 1752, 1716, 1680, 1611, 1589, 1524, 1491,
1456, 1379, 1363, 1322, 1278, 1260, 1233, 1195, 1167, 1141, 1108, 1083, 1047, 1005,
992, 952, 937, 899, 851, 834, 801, 773, 755, 732, 694, 628, 573, 555, 534, 458, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.0, 14.3, 15.2, 15.5, 16.2, 18.8, 19.8, 21.1, 22.3,
26.3, 28.2, 33.2, 37.9, 38.6, 40.2, 47.5, 49.8, 51.1, 65.9, 67.3, 69.5, 70.3, 76.1, 78.4, 78.5,
82.4, 84.6, 102.9, 103.7, 107.1, 112.8, 123.1, 131.0, 143.8, 153.9, 155.4, 166.5, 169.1,
172.6, 204.1

I-163

MS (SI): 885+ (M + H +). HRMS (SI): calcd for C44H65N6O13 885.4605 found 885.4598
IR (KBr): 3425, 3364, 2974, 2937, 2879, 2784, 1810, 1751, 1687, 1579, 1531, 1483, 1457,
1404, 1377, 1362, 1307, 1282, 1261, 1220, 1167, 1142, 1109, 1082, 1047, 1005, 992, 950,
896, 864, 833, 819, 768, 692, 632, 558, 537, 450, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.8, 14.3, 15.2, 15.5, 16.2, 18.9, 19.9, 21.2, 22.3, 26.4,
28.2, 33.3, 37.9, 40.2, 44.2, 47.6, 49.7, 51.1, 65.8, 69.5, 70.3, 76.1, 78.2, 78.4, 78.5, 82.3,
84.7, 103.7, 117.1, 123.2, 131.0, 133.5, 134.2, 142.4, 142.8, 145.3, 153.7, 167.0, 167.4,
169.2, 173.5, 204.1

I-164

MS (FAB): 861+ (M + H +). HRMS (FAB): calcd for C43H65N4O14 861.4497 found 861.4506
IR (KBr): 3439, 2975, 2938, 2880, 2786, 1809, 1751, 1716, 1676, 1617, 1526, 1499, 1457,
1380, 1307, 1281, 1236, 1167, 1142, 1109, 1084, 1047, 1006, 992, 952, 931, 899, 835,
781, 740, 693, 629, 574, 533, 454 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.3, 15.5, 16.2, 18.9, 19.8, 21.2, 22.3, 26.3,
28.2, 33.2, 38.0, 38.5, 40.2, 47.5, 49.7, 51.1, 65.9, 67.6, 69.5, 70.3, 76.0, 78.4, 78.5, 82.5,
84.7, 103.6, 103.7, 107.9, 126.3, 129.7, 150.9, 151.0, 151.6, 154.0, 166.5, 169.1, 172.6,
204.1

I-165

MS (FAB): 877+ (M + H +). HRMS (FAB): calcd for C43H65N4O13S 877.4269 found 877.4266
IR (KBr): 3438, 3073, 2974, 2938, 2879, 2785, 1808, 1751, 1715, 1677, 1566, 1528, 1456,
1378, 1328, 1273, 1235, 1167, 1142, 1109, 1082, 1047, 1005, 992, 952, 900, 864, 835,
772, 741, 691, 630, 573, 555, 532, 456 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.3, 15.2, 15.5, 16.1, 18.8, 19.8, 21.2, 22.3, 26.3,
28.2, 33.1, 37.9, 38.3, 40.2, 47.5, 49.7, 51.0, 65.8, 67.2, 69.5, 70.3, 76.0, 78.4, 78.5, 82.5,
84.7, 103.7, 108.1, 114.0, 126.6, 135.5, 143.6, 152.3, 152.9, 154.0, 166.3, 169.1, 172.6,
204.0

I-166

MS (SI): 958+ (M + H +). HRMS (SI): calcd for C48H72N5O15 958.5021 found 958.5029
IR (KBr): 3442, 2974, 2937, 2879, 2784, 1807, 1747, 1656, 1617, 1498, 1456, 1370, 1302,
1283, 1222, 1198, 1166, 1109, 1082, 1047, 1005, 992, 950, 875, 830, 775, 692, 659, 613,
553, 512, 454, 415 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 10.3, 12.9, 13.0, 14.3, 15.6, 15.7, 15.9, 16.0, 16.5, 18.8,
18.9, 19.9, 20.0, 20.7, 20.8, 21.2, 22.3, 22.5, 25.9, 28.3, 32.9, 38.2, 40.2, 46.7, 47.5, 47.8,
47.9, 48.0, 48.1, 49.5, 51.1, 51.2, 62.2, 62.7, 65.9, 66.2, 66.9, 69.5, 70.4, 73.1, 73.3, 75.9,
76.3, 78.3, 79.1, 82.4, 82.7, 84.6, 84.7, 103.8, 107.6, 107.9, 123.2, 130.4, 130.7, 139.3,
139.4, 142.3, 142.7, 144.6, 144.8, 144.9, 145.1, 154.4, 154.5, 159.6, 159.8, 164.9, 165.0,
168.9, 169.0, 170.6, 170.7, 172.7, 172.8, 203.9, 204.0

I-167

MS (SI): 916+ (M + H +). HRMS (SI): calcd for C46H70N5O14 916.4915 found 916.4911
IR (KBr): 3433, 2974, 2937, 2878, 2785, 1806, 1752, 1717, 1649, 1617, 1498, 1456, 1370,
1302, 1257, 1223, 1198, 1166, 1109, 1082, 1047, 1006, 993, 950, 873, 830, 775, 755, 692,
660, 620, 553, 511, 453, 415 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 10.4, 13.0, 14.3, 15.5, 16.1, 16.5, 16.6, 18.8, 18.9, 19.9,
20.0, 21.2, 22.4, 26.0, 26.1, 28.3, 32.9, 38.2, 40.2, 47.5, 48.1, 48.2, 48.5, 49.6, 51.1, 51.2,
51.3, 51.9, 61.6, 62.0, 65.9, 66.7, 66.8, 69.5, 70.4, 73.1, 73.3, 75.9, 76.1, 78.3, 79.2, 82.6,
82.7, 84.9, 85.0, 103.8, 107.6, 107.8, 123.1, 123.2, 130.4, 130.6, 139.2, 139.3, 142.3,
142.6, 144.6, 144.7, 144.9, 145.1, 154.7, 154.9, 159.5, 159.8, 164.8, 165.0, 168.9, 169.0,
173.0, 173.8, 203.9

I-168

MS (FAB): 917+ (M + H +). HRMS (FAB): calcd for C44H65N6O15 917.4508 found 917.4502
IR (CHCl3): 3378, 3018, 2970, 2932, 2870, 2780, 1795, 1750, 1624, 1562, 1516, 1454,
1433, 1378, 1360, 1324, 1281, 1255, 1226, 1219, 1158, 1141, 1108, 1083, 1045, 1005,
990, 949, 930, 907, 890, 860, 831, 799, 692, 663, 631, 566, 552, 540, 528, 522, 516, 512,
507, 501 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.4, 13.0, 14.3, 15.4, 15.9, 16.5, 18.8, 19.7, 21.0, 22.4, 26.1,
29.4, 32.9, 38.0, 40.1, 42.0, 47.7, 49.5, 51.1, 62.4, 66.4, 67.5, 68.6, 69.8, 71.8, 76.1, 78.0,
78.9, 82.3, 84.5, 102.8, 102.9, 118.5, 135.0, 135.9, 139.1, 141.4, 144.8, 145.6, 154.1,
164.6, 168.7, 172.1, 203.6

I-169

MS (FAB): 887+ (M + H +). HRMS (FAB): calcd for C44H67N6O13 887.4766 found 887.4783
IR (KBr): 3424, 2974, 2938, 2879, 2784, 1806, 1751, 1718, 1615, 1569, 1511, 1456, 1413,
1380, 1315, 1281, 1256, 1232, 1167, 1144, 1111, 1083, 1047, 1005, 992, 952, 908, 873,
830, 776, 756, 694, 614, 570, 531, 453, 434, 412 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.3, 15.4, 15.9, 16.7, 18.8, 19.8, 21.1, 22.4, 26.2,
28.7, 33.0, 38.0, 40.1, 43.1, 47.8, 49.5, 51.1, 63.4, 66.1, 67.5, 69.0, 70.0, 71.9, 76.1, 78.1,
79.1, 82.5, 84.6, 102.9, 103.3, 117.7, 118.9, 127.6, 134.4, 137.5, 140.9, 142.1, 154.3,
164.6, 168.7, 172.5, 203.6

I-170

MS (FAB): 916+ (M + H +). HRMS (FAB): calcd for C46H70N5O14 916.4919 found 916.4931
IR (KBr): 3440, 2974, 2937, 2878, 2784, 1809, 1751, 1716, 1676, 1617, 1525, 1498, 1455,
1371, 1303, 1284, 1257, 1224, 1199, 1166, 1139, 1111, 1083, 1047, 1005, 992, 949, 876,
830, 802, 774, 755, 682, 660, 613, 573, 553, 474, 456, 416 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 14.2, 15.3, 15.6, 16.1, 18.8, 19.8, 21.1, 22.3, 26.3,
28.3, 33.0, 37.9, 38.7, 40.1, 47.6, 49.7, 51.0, 65.8, 67.9, 68.9, 69.4, 69.8, 70.3, 76.0, 78.4,
78.5, 78.6, 82.4, 84.6, 103.7, 107.4, 123.7, 130.3, 139.2, 142.4, 144.5, 144.8, 153.9, 159.9,
166.4, 169.2, 172.3, 203.9

I-171

MS (FAB): 914+ (M + H +). HRMS (FAB): calcd for C44H72N5O13 914.5127 found 914.5115
IR (KBr): 3432, 2974, 2937, 2878, 2785, 1806, 1752, 1716, 1647, 1498, 1456, 1369, 1322,
1284, 1257, 1234, 1218, 1166, 1142, 1109, 1081, 1048, 1005, 993, 954, 895, 865, 831,
775, 755, 692, 665, 622, 511, 426, 409 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 10.3, 13.0, 14.3, 15.4, 15.5, 16.2, 16.5, 16.6, 18.8, 19.9,
20.0, 21.2, 22.4, 26.0, 28.3, 28.7, 30.8, 32.8, 33.1, 33.5, 38.2, 40.2, 47.4, 48.0, 48.1, 49.2,
49.5, 49.6, 50.4, 51.0, 51.1, 61.5, 62.0, 65.9, 69.5, 70.4, 73.4, 76.0, 76.1, 78.3, 79.2, 82.5,
82.7, 84.8, 103.8, 127.7, 127.8, 129.2, 129.4, 131.5, 141.8, 143.1, 143.2, 144.0, 144.1,
144.3, 144.7, 144.8, 145.0, 154.6, 154.7, 164.7, 164.9, 168.8, 168.9, 172.4, 173.2, 203.8

I-172

MS (SI): 941+ (M + H +). HRMS (SI): calcd for C49H77N6O12 941.5595 found 941.5596
IR (KBr): 3431, 2973, 2937, 2877, 2780, 1806, 1752, 1717, 1653, 1498, 1456, 1369, 1322,
1285, 1258, 1233, 1219, 1167, 1142, 1109, 1081, 1047, 1005, 993, 955, 932, 895, 865,
831, 775, 692, 626, 529, 510, 453, 425, 408 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 10.5, 13.0, 13.1, 14.2, 15.5, 15.6, 16.1, 16.2, 16.6, 16.7,
18.8, 20.0, 21.1, 21.2, 22.4, 22.5, 26.0, 26.1, 28.2, 28.7, 30.9, 32.8, 32.9, 33.1, 33.5, 38.1,
40.2, 44.7, 45.3, 45.6, 46.1, 47.0, 47.9, 48.0, 48.1, 49.6, 49.7, 51.1, 51.2, 56.3, 58.6, 65.9,
69.5, 70.4, 73.3, 73.7, 76.0, 76.3, 78.3, 79.3, 82.4, 84.4, 84.5, 103.8, 127.8, 127.9, 129.3,
129.4, 131.5, 131.6, 141.8, 141.9, 143.1, 143.2, 144.0, 144.3, 144.6, 144.8, 144.9, 154.3,
164.8, 168.8, 169.0, 171.6, 171.7, 203.8, 203.9

I-173

MS (FAB): 893+ (M + H +). HRMS (FAB): calcd for C43H65N4O14S 893.4218 found 893.4221
IR (KBr): 3435, 3090, 2974, 2938, 2879, 2785, 1808, 1751, 1698, 1612, 1585, 1531, 1492,
1455, 1380, 1322, 1276, 1234, 1169, 1109, 1082, 1047, 1006, 992, 951, 899, 834, 766,
723, 687, 643, 556, 531, 458, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.7, 14.2, 14.9, 15.3, 15.8, 18.7, 19.8, 21.2, 22.2, 26.1,
28.2, 32.9, 37.9, 38.9, 40.1, 47.8, 49.6, 51.0, 65.8, 68.1, 69.5, 70.3, 75.8, 78.1, 78.5, 82.8,
85.1, 103.7, 108.7, 114.6, 123.1, 124.5, 125.5, 144.3, 154.2, 165.5, 169.5, 170.8, 172.2,
203.8

I-174

MS (FAB): 892+ (M + H +). HRMS (FAB): calcd for C43H66N5O13S 892.4378 found 892.4374
IR (KBr): 3435, 3348, 2974, 2938, 2879, 2785, 1808, 1751, 1716, 1671, 1625, 1569, 1540,
1457, 1426, 1379, 1323, 1283, 1252, 1199, 1166, 1141, 1109, 1082, 1047, 1005, 992, 952,
898, 834, 771, 734, 682, 631, 573, 531, 457, 404 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.8, 14.3, 15.2, 15.7, 15.8, 18.7, 19.8, 21.2, 22.3, 26.3,
28.2, 33.1, 37.9, 38.6, 40.2, 47.7, 49.7, 51.0, 65.8, 67.4, 69.5, 70.3, 75.9, 78.3, 78.4, 78.6,
82.5, 84.9, 103.7, 108.7, 113.5, 121.8, 132.2, 141.9, 149.3, 154.1, 166.2, 167.2, 169.3,
172.6, 203.9

I-175

MS (SI): 927+ (M + H +). HRMS (SI): calcd for C48H75N6O12 927.5439 found 927.5439
IR (KBr): 3433, 2972, 2937, 2877, 2780, 1808, 1752, 1716, 1649, 1541, 1498, 1455, 1379,
1305, 1284, 1258, 1232, 1218, 1167, 1142, 1109, 1075, 1048, 1005, 992, 955, 931, 894,
865, 831, 776, 693, 667, 513, 407 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 10.4, 13.1, 14.3, 15.5, 15.8, 18.8, 19.8, 21.2, 22.4, 26.5,
28.2, 28.7, 30.1, 33.0, 33.4, 38.3, 40.2, 43.9, 45.3, 45.7, 45.8, 46.2, 47.5, 47.8, 49.7, 51.1,
56.6, 58.3, 65.9, 69.5, 70.3, 70.7, 70.9, 76.2, 78.5, 79.4, 82.6, 84.7, 103.8, 127.8, 127.9,
129.3, 129.6, 131.4, 131.6, 141.8, 141.9, 143.2, 143.7, 144.2, 144.4, 144.9, 145.1, 154.3,
165.9, 166.0, 168.9, 169.1, 169.2, 204.0

I-176

MS (FAB): 955+ (M + H +). HRMS (FAB): calcd for C50H79N6O12 955.5756 found 955.5738
IR (KBr): 3439, 3126, 2973, 2938, 2878, 2826, 2779, 1805, 1752, 1716, 1654, 1592, 1570,
1551, 1504, 1456, 1366, 1321, 1284, 1258, 1218, 1166, 1142, 1109, 1083, 1047, 1005,
993, 951, 925, 896, 862, 835, 776, 709, 620, 511, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 10.5, 13.0, 14.2, 15.6, 15.7, 16.2, 16.6, 18.8, 20.0, 21.2,
22.3, 22.5, 25.9, 26.0, 28.2, 29.3, 31.3, 32.7, 32.8, 38.1, 38.2, 40.2, 44.7, 45.0, 45.5, 45.7,
45.8, 46.2, 47.3, 47.7, 48.1, 49.6, 49.7, 51.1, 56.7, 58.7, 65.9, 69.5, 70.4, 73.4, 76.0, 76.3,
78.3, 79.3, 79.4, 82.5, 82.6, 84.5, 84.6, 103.8, 106.0, 106.4, 117.9, 118.0, 121.0, 121.3,
122.1, 122.2, 123.4, 131.8, 131.9, 132.0, 146.1, 146.3, 146.5, 154.3, 154.4, 164.7, 164.8,
168.9, 169.0, 171.5, 172.1, 203.8

I-177

MS (FAB): 943+ (M + H +). HRMS (FAB): calcd for C48H75N6O13 943.5392 found 943.5383
IR (CHCl3): 2970, 2934, 2868, 2826, 1797, 1751, 1713, 1648, 1609, 1575, 1493, 1456,
1407, 1380, 1359, 1323, 1297, 1258, 1232, 1219, 1161, 1141, 1105, 1083, 1045, 1004,
991, 949, 928, 724, 665, 526, 519, 515, 507 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 10.5, 13.0, 14.2, 15.5, 15.7, 16.2, 16.3, 16.6, 18.8, 18.8,
20.0, 21.2, 22.3, 22.5, 25.9, 26.0, 28.2, 32.8, 32.9, 38.2, 40.2, 44.7, 45.1, 47.0, 47.4, 47.6,
48.2, 49.5, 49.7, 51.2, 56.0, 57.6, 65.9, 66.1, 67.3, 69.5, 70.4, 73.4, 75.9, 76.2, 78.4, 79.3,
82.3, 82.6, 84.4, 84.7, 103.8, 109.0, 109.6, 121.0, 121.6, 130.3, 130.7, 135.4, 143.2, 143.4,
144.0, 145.1, 145.2, 154.0, 154.3, 154.4, 154.5, 164.5, 164.7, 169.0, 169.1, 172.6, 172.9,
203.8, 203.9

I-178

MS (FAB): 931+ (M + H +). HRMS (FAB): calcd for C47H75N6O13 931.5392 found 931.5401
IR (CHCl3): 2970, 2934, 2868, 2824, 2776, 1796, 1751, 1712, 1647, 1590, 1505, 1455,
1423, 1381, 1369, 1309, 1283, 1254, 1230, 1221, 1166, 1142, 1084, 1046, 1006, 990, 949,
894, 788, 721, 666, 557, 550, 544, 530, 526, 521, 515, 507 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 10.4, 12.9, 13.0, 14.2, 15.5, 15.6, 16.0, 16.6, 16.7, 18.7,
19.9, 21.2, 22.3, 22.4, 26.0, 28.2, 32.8, 38.1, 45.0, 45.1, 45.2, 46.5, 46.9, 47.4, 48.0, 48.1,
49.4, 49.5, 51.1, 56.2, 58.0, 65.7, 67.1, 68.2, 69.4, 70.3, 73.3, 73.5, 75.9, 76.0, 78.2, 78.3,
79.0, 79.1, 82.4, 84.4, 84.5, 103.6, 104.0, 104.1, 110.7, 111.0, 122.1, 122.3, 126.1, 140.1,
140.5, 142.5, 146.0, 164.6, 164.7, 168.7, 168.8, 171.8, 172.0, 203.4, 203.5

I-179

MS (FAB): 967+ (M + H +). HRMS (FAB): calcd for C51H79N6O12 967.5756 found 967.5755
IR (KBr): 3432, 2971, 2935, 2877, 2786, 1808, 1752, 1716, 1652, 1498, 1455, 1369, 1305,
1284, 1257, 1232, 1218, 1166, 1141, 1110, 1081, 1047, 1004, 993, 954, 931, 896, 865,
831, 775, 692, 667, 624, 568, 511, 451, 428, 408 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 10.5, 12.9, 13.0, 14.2, 15.4, 15.6, 16.0, 16.1, 16.5, 16.7,
18.8, 19.9, 21.1, 21.2, 22.3, 22.4, 23.4, 25.9, 26.0, 28.1, 28.7, 30.9, 32.7, 32.8, 33.1, 33.4,
38.1, 40.1, 45.2, 46.9, 47.9, 48.0, 48.1, 49.5, 49.6, 53.0, 53.9, 54.2, 55.1, 65.7, 69.4, 70.2,
73.2, 73.5, 75.9, 76.1, 78.2, 79.1, 82.2, 82.3, 84.3, 84.4, 103.6, 127.5, 127.6, 129.0, 129.1,
131.3, 131.4, 141.5, 141.6, 142.8, 142.9, 143.7, 143.8, 144.0, 144.3, 144.5, 144.6, 153.9,
154.0, 164.4, 164.5, 168.5, 168.6, 171.3, 171.4, 203.4, 203.5

I-180

MS (FAB): 983+ (M + H +). HRMS (FAB): calcd for C51H79N6O13 983.5705 found 983.5707
IR (KBr): 3444, 2971, 2937, 2877, 1808, 1752, 1716, 1652, 1498, 1455, 1369, 1322, 1301,
1284, 1257, 1218, 1166, 1141, 1114, 1081, 1047, 1006, 993, 954, 929, 894, 867, 831, 775,
692, 665, 626, 511, 408 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 10.5, 13.0, 14.2, 15.5, 15.6, 16.0, 16.1, 16.6, 16.7, 18.8,
18.9, 19.9, 21.1, 21.2, 22.3, 22.4, 25.9, 26.0, 28.2, 28.5, 30.9, 32.8, 32.9, 33.1, 33.5, 38.1,
40.2, 44.2, 45.2, 46.8, 47.9, 48.0, 48.1, 49.5, 49.6, 51.1, 51.2, 53.8, 54.0, 55.9, 58.0, 65.9,
66.9, 69.4, 70.3, 73.4, 73.9, 76.0, 76.2, 78.3, 79.2, 82.4, 82.5, 84.4, 103.7, 127.8, 127.9,
129.3, 129.4, 131.4, 131.6, 141.8, 141.9, 143.1, 143.2, 144.0, 144.1, 144.3, 144.5, 144.8,
145.0, 154.3, 154.4, 164.7, 164.9, 168.9, 171.4, 171.5, 203.8

I-181

MS (FAB): 873+ (M + H +). HRMS (FAB): calcd for C44H69N6O12 873.4973 found 873.4982
IR (KBr): 3430, 3089, 3054, 2975, 2937, 2879, 2784, 1806, 1751, 1716, 1652, 1598, 1583,
1500, 1455, 1409, 1369, 1322, 1286, 1259, 1232, 1220, 1197, 1168, 1108, 1083, 1047,
1006, 993, 952, 931, 896, 863, 835, 802, 775, 746, 690, 636, 511, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 10.3, 12.9, 14.2, 15.4, 15.7, 15.9, 16.4, 16.6, 18.7, 18.8,
19.9, 21.1, 21.2, 22.3, 22.4, 25.8, 26.0, 27.3, 28.7, 29.3, 32.9, 33.8, 35.4, 38.0, 40.1, 41.3,
41.5, 45.3, 47.3, 47.8, 49.2, 49.5, 51.0, 65.8, 69.1, 70.1, 73.2, 73.5, 75.9, 76.0, 78.9, 79.0,
82.2, 82.4, 84.4, 84.5, 103.4, 117.7, 117.9, 123.5, 124.7, 127.4, 127.6, 135.2, 143.6, 143.8,
144.5, 146.8, 154.0, 154.3, 164.2, 164.8, 168.6, 168.7, 170.9, 171.5, 203.3, 203.4

I-182

MS (FAB): 886+ (M + H +). HRMS (FAB): calcd for C45H68N5O13 886.4814 found 886.4805
IR (KBr): 3440, 2975, 2937, 2879, 2784, 1806, 1751, 1716, 1652, 1614, 1569, 1482, 1457,
1382, 1307, 1284, 1259, 1234, 1168, 1110, 1083, 1047, 1004, 993, 952, 931, 896, 835,
767, 740, 721, 690, 622, 512, 449 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 14.2, 15.4, 15.6, 16.1, 16.3, 16.5, 18.7, 18.8, 19.9,
21.2, 22.4, 22.5, 25.8, 26.0, 28.2, 32.9, 33.0, 34.3, 37.3, 38.1, 40.2, 47.6, 48.0, 48.8, 49.4,
49.5, 51.1, 65.4, 65.9, 66.7, 69.5, 70.4, 73.3, 73.6, 76.0, 78.4, 79.1, 82.3, 82.6, 84.5, 84.7,
103.8, 113.0, 113.3, 118.4, 118.9, 126.0, 128.3, 128.4, 128.6, 142.2, 142.3, 153.7, 153.8,
154.2, 154.3, 154.4, 154.6, 159.8, 164.1, 164.9, 169.1, 172.0, 172.1, 203.9

I-183

MS (FAB): 996+ (M + H +). HRMS (FAB): calcd for C52H82N7O12 996.6021 found 996.6029
IR (KBr): 3444, 2973, 2937, 2877, 2840, 2794, 2690, 1808, 1752, 1716, 1652, 1498, 1455,
1369, 1299, 1284, 1257, 1232, 1218, 1166, 1141, 1110, 1083, 1047, 1008, 993, 954, 929,
894, 865, 831, 794, 775, 692, 665, 624, 509, 447, 431, 406 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 10.4, 13.0, 14.2, 15.5, 15.6, 16.0, 16.6, 16.8, 18.8, 19.9,
21.1, 21.2, 22.3, 22.4, 26.0, 26.1, 28.3, 28.5, 30.9, 32.9, 33.1, 33.5, 38.1, 40.2, 44.3, 45.5,
45.8, 46.9, 47.9, 48.0, 49.5, 49.6, 50.2, 51.1, 53.0, 53.3, 54.8, 54.9, 55.3, 57.5, 65.8, 69.4,
70.4, 73.5, 73.8, 76.0, 76.2, 78.3, 79.2, 82.4, 82.5, 84.5, 84.6, 103.7, 127.7, 127.8, 129.2,
129.3, 131.6, 131.7, 141.8, 143.1, 143.2, 144.0, 144.2, 144.3, 144.7, 144.8, 144.9, 164.8,
164.9, 168.9, 169.0, 171.5, 171.7, 203.8, 203.9

I-184

MS (FAB): 955+ (M + H +). HRMS (FAB): calcd for C50H79N6O12 955.5757 found 955.5743
IR (KBr): 3444, 2973, 2937, 2877, 2819, 2782, 1808, 1752, 1716, 1687, 1652, 1569, 1498,
1457, 1367, 1321, 1284, 1259, 1218, 1166, 1141, 1110, 1081, 1047, 1006, 993, 954, 931,
894, 867, 831, 775, 755, 692, 665, 628, 566, 511, 453, 430, 408 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 10.4, 13.0, 14.2, 15.5, 15.6, 16.0, 16.7, 16.9, 18.8, 18.9,
19.9, 21.2, 21.3, 22.3, 22.4, 25.0, 26.0, 27.7, 28.2, 28.4, 28.6, 32.9, 33.1, 33.5, 38.1, 40.2,
44.8, 45.2, 45.9, 46.4, 47.6, 48.0, 48.1, 49.5, 49.6, 51.1, 56.4, 56.8, 65.9, 69.5, 70.3, 73.7,
73.8, 76.0, 76.2, 78.3, 79.3, 82.5, 84.5, 103.8, 127.7, 127.8, 129.3, 129.4, 131.5, 131.6,
141.8, 141.9, 143.1, 143.2, 144.0, 144.3, 144.6, 144.8, 144.9, 154.3, 164.7, 164.8, 168.8,
169.0, 171.5, 171.6, 203.8

I-185

MS (FAB): 990+ (M + H +). HRMS (FAB): calcd for C52H76N7O12 990.5552 found 990.5547
IR (KBr): 3417, 2973, 2937, 2877, 2784, 1806, 1752, 1716, 1652, 1604, 1571, 1498, 1455,
1369, 1322, 1286, 1257, 1234, 1218, 1166, 1110, 1081, 1047, 1004, 993, 954, 931, 894,
865, 831, 773, 736, 682, 626, 511, 455, 408 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 10.4, 13.0, 14.2, 14.3, 15.5, 15.6, 16.1, 16.2, 16.7, 16.8,
18.8, 19.9, 20.0, 21.2, 22.4, 26.0, 28.2, 28.6, 30.9, 32.8, 33.1, 33.5, 38.2, 40.2, 40.6, 41.7,
47.1, 47.2, 47.4, 48.1, 48.2, 48.7, 49.5, 49.6, 51.1, 65.9, 69.5, 70.4, 73.5, 74.0, 75.9, 76.0,
78.3, 79.3, 79.4, 82.5, 82.6, 84.7, 84.9, 103.8, 107.6, 108.6, 112.3, 112.6, 127.7, 127.8,
129.2, 129.4, 131.5, 136.9, 137.1, 141.8, 141.9, 143.1, 143.2, 143.9, 144.0, 144.3, 144.6,
144.7, 144.9, 147.7, 147.8, 154.6, 154.9, 158.5, 158.6, 164.3, 164.6, 168.8, 168.9, 172.2,
172.5, 203.8, 203.9

I-186

MS (FAB): 954+ (M + H +). HRMS (FAB): calcd for C49H76N7O12 954.5552 found 954.5544
IR (KBr): 3434, 2973, 2937, 2877, 2784, 1810, 1751, 1716, 1654, 1521, 1498, 1455, 1367,
1322, 1284, 1257, 1218, 1166, 1141, 1108, 1083, 1047, 1004, 993, 954, 931, 894, 865,
831, 775, 755, 692, 665, 628, 511, 457, 408 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 10.3, 10.5, 12.8, 13.0, 14.2, 15.3, 15.5, 15.7, 15.8, 16.0,
16.6, 16.8, 18.8, 18.9, 19.9, 21.1, 21.2, 22.2, 22.3, 22.4, 26.0, 26.2, 28.2, 28.6, 30.5, 32.8,
33.1, 33.4, 33.5, 37.9, 38.1, 38.9, 40.2, 42.8, 42.9, 46.7, 46.8, 47.7, 48.0, 48.5, 49.4, 49.5,
49.8, 49.9, 51.0, 51.1, 65.9, 69.4, 70.3, 73.8, 74.1, 75.9, 76.0, 76.2, 78.3, 78.4, 78.5, 79.1,
79.2, 82.4, 82.5, 84.3, 84.5, 84.6, 103.7, 127.7, 127.8, 127.9, 129.1, 129.2, 129.3, 130.9,
131.6, 131.7, 132.2, 141.8, 141.9, 143.1, 143.2, 144.0, 144.1, 144.2, 144.5, 144.7, 144.8,
144.9, 153.8, 154.1, 154.4, 164.6, 164.7, 166.3, 168.8, 169.0, 169.3, 171.7, 171.8, 172.1,
203.8, 203.9

I-187

MS (FAB): 871+ (M + H +). HRMS (FAB): calcd for C44H67N6O12 871.4817 found 871.4816
IR (KBr): 3384, 3060, 2975, 2937, 2879, 2784, 1810, 1751, 1716, 1673, 1614, 1585, 1535,
1496, 1455, 1411, 1378, 1305, 1284, 1257, 1234, 1166, 1141, 1108, 1083, 1047, 1004,
993, 952, 931, 898, 863, 835, 761, 682, 613, 574, 532, 457, 414 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.7, 14.3, 15.2, 15.5, 15.7, 18.8, 19.9, 21.2, 22.2, 26.1,
28.2, 33.0, 37.9, 38.7, 40.2, 41.8, 47.7, 49.7, 51.0, 65.9, 70.3, 75.7, 78.3, 78.4, 78.5, 82.6,
85.2, 103.7, 123.8, 126.4, 128.7, 129.5, 137.1, 139.5, 142.0, 152.4, 154.5, 166.0, 169.4,
173.1, 203.8

I-188

MS (FAB): 771+ (M + H +). HRMS (FAB): calcd for C38H67N4O12 771.4755 found 771.4747
IR (KBr): 3424, 2975, 2938, 2879, 2825, 2780, 1812, 1751, 1716, 1675, 1519, 1457, 1380,
1363, 1322, 1284, 1257, 1232, 1166, 1141, 1110, 1083, 1047, 1004, 993, 952, 900, 862,
835, 802, 773, 755, 694, 632, 574, 514, 453, 433, 418 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.4, 13.0, 14.3, 15.3, 15.6, 16.4, 18.8, 19.9, 21.2, 22.4, 26.4,
28.2, 33.2, 36.8, 38.0, 40.2, 45.2, 47.6, 49.7, 51.1, 57.9, 65.8, 69.5, 70.3, 76.2, 78.4, 78.5,
78.6, 82.5, 84.6, 103.7, 154.0, 166.5, 169.1, 172.1, 204.0

I-189

MS (FAB): 871+ (M + H +). HRMS (FAB): calcd for C44H67N6O12 871.4817 found 871.4827
IR (KBr): 3428, 3062, 2975, 2937, 2879, 2784, 1810, 1751, 1716, 1670, 1619, 1583, 1540,
1496, 1455, 1359, 1319, 1284, 1257, 1234, 1166, 1141, 1110, 1081, 1047, 1006, 993, 952,
900, 835, 800, 771, 686, 630, 572, 539, 466 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.7, 14.3, 15.2, 15.6, 15.7, 18.8, 19.8, 21.2, 22.2, 26.2,
28.3, 33.1, 37.8, 38.8, 40.2, 43.8, 47.6, 49.7, 51.0, 65.8, 69.5, 70.3, 75.8, 78.2, 78.5, 82.4,
85.0, 103.7, 115.3, 121.8, 125.9, 127.9, 132.2, 149.1, 154.1, 155.4, 159.8, 166.4, 169.4,
174.8, 203.9

III (12)

I-190

MS (FAB): 729+ (M + H +). HRMS (FAB): calcd for C35H61N4O12 729.4286 found 729.4285
IR (KBr): 3416, 2972, 2938, 2879, 2783, 1809, 1752, 1669, 1555, 1457, 1380, 1303, 1284,
1257, 1234, 1166, 1110, 1078, 1048, 987, 932, 893, 776, 695, 616, 529, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.9, 14.2, 15.4, 15.9, 18.8, 19.9, 21.2, 22.3, 26.4, 28.2,
32.9, 35.9, 38.1, 40.1, 47.9, 49.1, 51.0, 65.9, 69.4, 70.2, 74.0, 76.0, 78.5, 79.4, 82.9, 84.7,
103.8, 154.5, 157.4, 165.0, 169.2, 203.8

I-191

MS (FAB): 772+ (M + H +). HRMS (FAB): calcd for C37H66N5O12 772.4708 found 772.4709
IR (KBr): 3435, 2972, 2938, 2880, 2786, 1809, 1752, 1716, 1662, 1525, 1457, 1364, 1322,
1305, 1283, 1259, 1216, 1166, 1110, 1078, 1048, 987, 931, 895, 833, 775, 695, 622, 591,
560, 529, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.2, 15.5, 15.7, 18.6, 19.8, 21.2, 22.3, 26.5, 28.2,
32.9, 37.2, 38.3, 40.2, 44.8, 47.8, 49.6, 51.0, 58.5, 65.8, 69.4, 70.3, 74.9, 76.2, 78.3, 79.3,
82.9, 84.8, 103.8, 154.2, 158.4, 166.0, 169.1, 203.7

I-192

MS (SI): 716+ (M + H +). HRMS (SI): calcd for C34H58N3O13 716.3966 found 716.3969
IR (KBr): 3439, 2973, 2938, 2880, 1809, 1746, 1632, 1514, 1457, 1381, 1324, 1284, 1237,
1165, 1110, 1077, 1049, 1006, 989, 957, 931, 908, 779 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.2, 15.5, 15.7, 18.7, 19.8, 21.2, 22.4, 26.5, 28.3,
33.0, 38.2, 40.1, 47.8, 49.3, 51.1, 52.1, 65.9, 69.4, 70.3, 74.3, 76.3, 78.4, 79.2, 82.9, 84.7,
103.7, 154.5, 156.7, 166.0, 169.1, 203.9

IV (10)

I-193

MS (FAB): 701+ (M + H +). HRMS (FAB): calcd for C34H57N2O13 701.3861.found 7013866.
IR (KBr): 3448, 2974, 2938, 2880, 2786, 1812, 1752, 1718, 1636, 1457, 1380, 1361, 1324,
1304, 1284, 1257, 1210, 1167, 1142, 1108, 1084, 1047, 1004, 993, 953, 932, 889, 860,
835, 773, 693, 631, 582, 566, 530, 512, 455, 432 (cm-1).
13C-NMR (CDCl3): δ (ppm) 10.4, 13.1, 14.3, 15.2, 15.9, 18.8, 19.7, 21.1, 22.4, 26.7, 28.1,
33.2, 38.2, 40.2, 47.8, 49.6, 51.1, 51.5, 65.8, 69.4, 70.3, 76.3, 78.4, 79.4, 82.5, 84.7, 103.8,
154.3, 166.1, 169.0, 170.5, 204.0

I-194

MS (SI): 805+ (M + H +). HRMS (SI): calcd for C42H65N2O13 805.4483 found 805.4486
IR (KBr): 3447, 2924, 2877, 2851, 2785, 1810, 1752, 1653, 1636, 1628, 1604, 1569, 1560,
1542, 1508, 1497, 1456, 1381, 1362, 1323, 1304, 1284, 1258, 1167, 1142, 1108, 1084,
1047, 1004, 993, 953, 932, 891, 860, 834, 800, 773, 748, 700, 632, 567, 529, 512, 455,
432, 411 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.4, 13.2, 14.3, 15.3, 15.8, 18.8, 19.7, 21.1, 22.5, 26.7, 28.2,
29.7, 30.1, 32.1, 38.3, 40.2, 47.8, 49.7, 51.1, 64.0, 65.9, 69.5, 70.3, 70.5, 76.4, 78.5, 79.5,
82.5, 84.8, 103.8, 126.0, 128.4, 128.5, 141.1, 154.3, 166.0, 169.1, 170.1, 204.1


V (16)

I-195

MS (FAB): 730+ (M + H +). HRMS (FAB): calcd for C35H60N3O13 730.4126 found 730.4122
IR (CHCl3): 3598, 3022, 3004, 2934, 1800, 1752, 1712, 1599, 1515, 1454, 1381, 1229,
1227, 1200, 1166, 1108, 1072, 1047, 991 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 12.9, 14.0, 15.3, 15.5, 18.5, 19.5, 20.9, 22.1, 25.8, 27.9,
32.7, 37.9, 40.0, 42.0, 47.5, 49.2, 50.8, 51.7, 65.5, 69.2, 70.0, 71.6, 76.1, 78.1, 78.7, 82.7,
84.2, 103.5, 153.7, 157.0, 165.1, 168.8, 203.7

I-196

MS (FAB): 790+ (M + H +). HRMS (FAB): calcd for C41H64N3O12 790.4490 found 790.4487
IR (CHCl3): 3390, 3022, 3008, 2974, 2934, 2872, 1805, 1751, 1730, 1656, 1513, 1495,
1454, 1375, 1361, 1305, 1251, 1236, 1230, 1227, 1201, 1166, 1139, 1108, 1072, 1045,
1006, 989, 951 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 12.9, 14.0, 15.5, 15.6, 18.5, 19.6, 21.0, 22.1, 25.7, 28.0,
32.7, 38.0, 40.0, 41.4, 42.8, 47.5, 49.3, 50.9, 65.6, 69.3, 70.1, 71.6, 76.0, 78.2, 78.7, 82.9,
84.6, 103.6, 126.4, 128.3, 128.9, 135.7, 153.8, 165.7, 168.9, 171.1, 203.7

I-197

MS (FAB): 757+ (M + H +). HRMS (FAB): calcd for C37H65N4O12 757.4599 found 757.4603
IR (CHCl3): 3372, 3020, 2972, 2934, 2870, 2780, 1798, 1751, 1715, 1665, 1523, 1455,
1382, 1360, 1305, 1282, 1232, 1229, 1199, 1167, 1108, 1072, 1046, 1006, 990, 951, 930,
908 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 12.8, 14.0, 15.1, 15.5, 18.5, 19.5, 20.9, 22.1, 25.9, 28.0,
32.7, 37.9, 38.9, 40.0, 45.6, 47.5, 49.3, 50.8, 62.8, 65.5, 69.2, 70.0, 71.7, 76.1, 78.1, 78.8,
82.6, 84.4, 103.5, 154.0, 165.0, 168.8, 170.4, 203.7

I-198

MS (FAB): 832+ (M + H +). HRMS (FAB): calcd for C44H70N3O12 832.4960 found 832.4952
IR (CHCl3): 3398, 3024, 2976, 2938, 2874, 1806, 1752, 1717, 1651, 1602, 1513, 1455,
1382, 1362, 1305, 1283, 1257, 1231, 1167, 1139, 1108, 1073, 1045, 1006, 990, 951,
908 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.0, 12.8, 14.0, 15.4, 18.4, 19.6, 20.9, 22.0, 25.4, 25.7, 28.3,
30.9, 32.6, 35.4, 35.8, 37.9, 39.8, 41.6, 47.4, 49.3, 50.8, 65.6, 69.0, 69.9, 71.5, 75.9, 78.2,
78.6, 82.8, 84.4, 103.4, 125.2, 127.9, 128.2, 142.3, 153.6, 165.6, 168.9, 173.4, 203.6

I-199

MS (FAB): 791+ (M + H +). HRMS (FAB): calcd for C40H63N4O12 791.4442 found 791.4445
IR (CHCl3): 3388, 3016, 2970, 2934, 2872, 1801, 1752, 1715, 1661, 1593, 1571, 1516,
1454, 1382, 1360, 1323, 1305, 1283, 1257, 1228, 1166, 1140, 1108, 1073, 1047, 1006,
990, 951 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.1, 15.5, 15.6, 18.6, 19.7, 21.0, 22.3, 25.9, 28.1,
32.8, 38.1, 40.1, 40.7, 45.2, 47.6, 49.4, 51.0, 65.7, 69.4, 70.2, 71.7, 76.3, 78.3, 78.9, 83.0,
84.6, 103.6, 121.6, 123.7, 136.5, 149.1, 154.0, 155.9, 165.4, 168.9, 169.7, 203.9

I-200

MS (FAB): 847+ (M + H +). HRMS (FAB): calcd for C44H71N4O12 847.5068 found 847.5067
IR (CHCl3): 3384, 2970, 2934, 2868, 2782, 1804, 1751, 1715, 1663, 1512, 1454, 1382,
1360, 1305, 1283, 1256, 1231, 1227, 1166, 1108, 1073, 1046, 991, 950 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.0, 15.3, 15.5, 18.5, 19.6, 21.0, 22.2, 25.7, 27.9,
32.6, 34.4, 37.9, 40.0, 40.1, 42.1, 47.5, 49.2, 50.8, 65.6, 69.3, 70.1, 70.7, 71.7, 76.1, 78.2,
78.8, 82.7, 84.4, 103.6, 125.7, 127.9, 129.2, 139.3, 153.9, 165.2, 168.8, 171.7, 203.7

I-201

MS (FAB): 804+ (M + H +). HRMS (FAB): calcd for C42H66N3O12 804.4646 found 804.4642
IR (CHCl3): 3392, 3022, 2970, 2934, 2872, 1805, 1752, 1716, 1651, 1515, 1454, 1382,
1361, 1305, 1283, 1256, 1228, 1166, 1139, 1108, 1073, 1045, 1006, 990, 951, 929,
908 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.0, 12.9, 14.0, 15.5, 18.5, 19.6, 21.0, 22.0, 25.7, 28.0, 31.5,
32.6, 37.2, 37.9, 40.0, 41.6, 47.5, 49.3, 50.8, 65.6, 69.3, 70.1, 71.6, 76.0, 78.2, 78.7, 82.9,
84.4, 103.6, 125.6, 128.0, 128.2, 141.1, 153.6, 165.5, 168.8, 172.4, 203.7

I-202

MS (FAB): 818+ (M + H +). HRMS (FAB): calcd for C43H68N3O12 818.4803 found 818.4801
IR (CHCl3): 3400, 3029, 3016, 2977, 2939, 2878, 2788, 1806, 1752, 1717, 1652, 1602,
1513, 1455, 1383, 1361, 1323, 1305, 1284, 1257, 1205, 1167, 1140, 1109, 1074, 1046,
1006, 991, 952, 931, 916 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 12.9, 14.1, 15.5, 18.5, 19.7, 21.0, 22.1, 25.7, 27.6, 28.0,
32.6, 35.1, 35.6, 38.0, 40.0, 41.5, 47.5, 49.4, 50.9, 65.7, 69.3, 70.1, 71.7, 76.1, 78.2, 78.8,
82.9, 84.5, 103.6, 125.4, 128.0, 128.4, 142.0, 153.7, 165.6, 169.0, 173.2, 203.6

I-203

MS (FAB): 856+ (M + H +). HRMS (FAB): calcd for C44H66N5O12 856.4708 found 856.4713
Anal Calcd for C44H65N5O12 (H2O) 1.2: C 60.22, H 7.74, N 7.98 Found C 60.17, H 7.50, N
7.82
IR (KBr): 3397, 2972, 2937, 2878, 2784, 1809, 1751, 1716, 1670, 1500, 1455, 1380, 1322,
1305, 1284, 1258, 1233, 1219, 1167, 1141, 1109, 1075, 1046, 1005, 992, 954, 930, 913,
866, 832, 799, 769, 754, 693, 666, 622, 580, 531, 512, 456, 407 (cm-1)
13C-NMR (CDCl3): δ (ppm) 9.9, 12.9, 14.1, 15.4, 15.5, 18.5, 19.7, 21.0, 22.0, 25.7, 28.0, 31.5,
32.6, 36.3, 37.9, 40.0, 41.8, 47.5, 49.4, 50.8, 65.7, 69.3, 70.1, 71.6, 76.0, 78.2, 78.7, 82.9,
84.5, 103.6, 127.8, 128.8, 131.7, 141.6, 143.0, 143.9, 144.0, 144.6, 153.7, 165.7, 169.0,
172.0, 203.7

I-204

MS (FAB): 870+ (M + H +). HRMS (FAB): calcd for C45H68N5O12 870.4864 found 870.4861
Anal Calcd for C45H67N5O12 (H2O) 0.7: C 61.23, H 7.81, N 7.93 Found C 61.25, H 7.62, N
7.78
IR (KBr): 3400, 2972, 2937, 2877, 2784, 1809 1751, 1716, 1669 1499, 1455, 1380, 1323,
1304, 1284, 1257, 1233, 1219, 1167, 1141, 1109, 1075, 1047, 1005, 992, 955, 930, 913,
896, 866, 832, 798, 779, 754, 693, 665, 622, 581, 561, 530, 512, 456, 426, 409 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.2, 15.6, 15.7, 18.6, 19.8, 21.1 22.3, 25.9, 27.3,
28.2, 32.8, 35.4, 35.7, 38.1, 40.2, 41.9, 47.7, 49.5, 51.0, 65.8, 69.5, 70.3, 71.9, 76.2, 78.4,
78.9, 83.1, 84.7, 103.8, 127.8, 129.0, 131.9, 141.7, 143.2, 144.0, 144.7, 145.0, 153.9,
165.9, 169.2, 173.1, 203.8

I-205

MS (FAB): 855+ (M + H +). HRMS (FAB): calcd for C45H67N4O12 855.4755 found 855.4752
Anal Calcd for C45H66N4O12 (H2O) 0.3: C 62.82, H 7.80, N 6.51 Found C 62.87, H 7.78, N
6.35
IR (KBr): 3397, 3064, 2972, 2937, 2877, 2784, 1809, 1751, 1716, 1671, 1592, 1568, 1509,
1455, 1380, 1322, 1304, 1284, 1257, 1234, 1167, 1141, 1109, 1075, 1047, 1005, 992, 953,
931, 914, 842, 798, 766, 693, 623, 582, 554, 512, 455, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 13.0, 14.3, 15.6, 18.6, 19.9, 21.2, 22.2, 25.8, 27.4, 28.2,
32.7, 35.2, 38.1, 40.2, 42.1, 47.7, 49.6, 51.0, 65.8, 69.5, 70.3, 71.7, 76.1, 78.4, 78.9, 83.1,
84.7, 103.8, 120.5, 123.9, 126.3, 127.6, 128.9, 129.9, 147.4, 148.1, 150.2, 153.8, 165.9,
169.2, 172.1, 203.8

I-206

MS (FAB): 858+ (M + H +). HRMS (FAB): calcd for C45H72N5O11 858.5228 found 858.5218
Anal Calcd for C45H71N5O11 (H2O) 0.8: C 61.95, H 8.39, N 8.03 Found C 61.93, H 8.22, N
8.01
IR (KBr): 3412, 3063, 3032, 2973, 2938, 2876, 2838, 1746, 1705, 1676, 1621, 1586, 1498,
1455, 1406, 1379, 1331, 1294, 1254, 1175, 1116, 1092, 1065, 1025, 984, 937, 891, 868,
828, 783, 767, 755, 739, 698, 667, 609, 518, 470, 407 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.5, 14.1, 14.4, 14.9, 16.3, 19.5, 20.4, 21.2, 22.2, 27.3, 28.3,
31.6, 37.6, 40.2, 40.7, 46.7, 49.9, 51.3, 53.4, 61.5, 65.8, 69.5, 70.3, 71.4, 77.8, 78.9, 80.7,
103.9, 127.8, 129.3, 131.6, 141.8, 143.1, 143.8, 144.4, 144.9, 168.1, 169.2, 171.5, 204.2

I-207

MS (FAB): 757+ (M + H +). HRMS (FAB): calcd for C37H65N4O12 757.4599 found 757.4597
Anal Calcd for C37H64N4O12 (H2O) 0.3: C 58.30, H 8.54, N 7.35 Found C 58.30, H 8.41, N
7.22
IR (KBr): 3450, 2974, 2939, 2879 2785, 1812, 1752, 1717, 1659, 1457, 1397, 1380, 1360,
1323, 1304, 1284, 1258, 1233, 1218, 1165, 1109, 1078, 1049, 1005, 992, 953, 932, 908,
835, 774, 693, 629, 604, 574, 527, 456, 432 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.3, 15.6, 15.8, 18.7, 19.9, 21.2, 22.4, 26.2, 28.2,
33.0, 37.7, 38.2, 40.2, 43.7, 44.1, 47.8, 49.6, 51.1, 65.9, 69.5, 70.4, 70.9, 76.3, 78.5, 79.2,
82.8, 84.5, 103.9, 154.4, 164.6, 169.2, 173.7, 204.0

I-208

MS (FAB): 899+ (M + H +). HRMS (FAB): calcd for C46H71N6O12 899.5130 found 899.5135
Anal Calcd for C46H70N6O12 (H2O) 0.4: C 60.96, H 7.87, N 9.27 Found C 60.91, H 7.77, N
9.26
IR (KBr): 3444, 2973, 2938, 2878, 2785, 1811, 1751, 1716, 1654, 1498, 1455, 1410, 1379,
1323, 1305, 1284, 1258, 1218, 1165, 1109, 1076, 1048, 1005, 992, 954, 931, 894, 865,
832, 773, 755, 693, 666, 620, 581, 558, 528, 514, 455, 408 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.3, 15.6, 15.8, 18.7, 19.9, 21.2, 22.4, 26.1, 28.2,
31.3, 33.0, 34.1, 37.9, 38.2, 40.2, 43.8, 44.2, 47.8, 49.6, 51.1, 65.9, 69.5, 70.4, 70.8, 76.3,
78.5, 79.1, 82.8, 84.5, 103.8, 127.7, 129.2, 131.9, 141.8, 143.2, 144.2, 144.7, 144.9, 154.3,
164.6, 169.2, 174.5, 204.0

I-209

MS (FAB): 858+ (M + H +). HRMS (FAB): calcd for C43H64N5O13 858.4501 found 858.4508
Anal Calcd for C43H63N5O13 (H2O) 0.5: C 59.57, H 7.44, N 8.07 Found C 59.55, H 7.37, N
7.91
IR (KBr): 3427, 3070, 2972, 2937, 2878, 2784, 1807, 1751, 1716, 1683, 1612, 1576, 1540,
1494, 1474, 1456, 1380, 1359, 1301, 1259, 1222, 1165, 1141, 1109, 1076, 1048, 1005,
992, 953, 932, 900, 863, 830, 758, 693, 622, 557, 528, 455, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.3, 15.5, 15.7, 18.8, 19.8, 21.1, 22.4, 26.2, 28.2,
33.1, 38.2, 39.4, 40.2, 47.8, 49.7, 51.1, 65.9, 69.5, 69.6, 70.4, 71.5, 76.3, 78.4, 79.2, 82.9,
84.7, 103.8, 111.7, 122.9, 130.0, 135.4, 143.9, 144.0, 145.7, 153.7, 154.3, 165.3, 168.1,
169.0, 203.9

I-210

MS (FAB): 858+ (M + H +). HRMS (FAB): calcd for C43H64N5O13 858.4501 found 858.4506
Anal Calcd for C43H63N5O13 (H2O) 0.4: C 59.69, H 7.43, N 8.09 Found C 59.72, H 7.34, N
7.96
IR (KBr): 3434, 2973, 2937, 2878, 2784, 1808, 1751, 1715, 1684, 1617, 1533, 1497 1455,
1378, 1302, 1257, 1220, 1198, 1166, 1109, 1075, 1047, 1005, 992, 954, 930, 914, 875,
830, 799, 778, 755, 693, 658, 618, 549, 456, 415 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.1, 14.3, 15.6, 18.8, 19.8, 21.2, 22.3, 26.1, 28.2, 33.0,
38.2, 40.2, 40.3, 47.7, 49.7, 51.1, 65.9, 67.7, 69.5, 70.3, 71.7, 76.3, 78.4, 79.1, 82.9, 84.7,
103.8, 108.5, 123.2, 130.8, 139.5, 142.9, 144.5, 145.1, 154.1, 158.6, 165.8, 167.4, 169.2,
204.0

I-211

MS (FAB): 888+ (M + H +). HRMS (FAB): calcd for C44H66N5O14 888.4606 found 888.4608
Anal Calcd for C44H65N5O14 (H2O): C 58.33, H 7.45, N 7.73 Found C 58.38, H 7.32, N
7.33
IR (KBr): 3419, 3063, 2973, 2938, 2878, 2785, 1807, 1751, 1695, 1529, 1456, 1382, 1322,
1305, 1284, 1256, 1235, 1167, 1142, 1109, 1075, 1047, 1005, 992, 953, 932, 902, 829,
779, 755, 681, 620, 567, 464 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.3, 15.6, 15.8, 18.7, 19.9, 21.2, 22.3, 26.0, 28.5,
31.5, 33.0, 37.1, 38.2, 40.3, 41.5, 47.8, 49.6, 51.1, 65.8, 69.4, 70.3, 71.8, 76.3, 78.5, 79.1,
83.2, 85.0, 103.8, 115.8, 116.1, 123.1, 124.4, 124.9, 137.5, 154.2, 156.1, 165.9, 169.3,
173.2, 203.9

I-212

MS (FAB): 871+ (M + H +). HRMS (FAB): calcd for C44H67N6O12 871.4817 found 871.4811
Anal Calcd for C44H66N6O12 (H2O) 0.5: C 60.05, H 7.67, N 9.55 Found C 60.11, H 7.72, N
9.45
IR (KBr): 3392, 2972, 2937, 2878, 2784, 1806, 1750, 1716, 1672, 1598, 1548, 1516, 1455,
1407, 1380, 1323, 1304, 1285, 1257, 1233, 1169, 1141, 1109, 1074, 1047, 1005, 992, 951,
941, 913, 834, 813, 778, 755, 710, 693, 627, 555, 512, 456 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.2, 15.6, 18.5, 19.8, 21.1, 22.2, 25.8, 28.3, 32.7,
37.1, 38.1, 40.2, 42.3, 43.5, 47.7, 49.5, 51.0, 65.8, 69.5, 70.3, 71.5, 76.1, 78.4, 78.9, 83.2,
84.9, 103.9, 116.0, 123.4, 130.5, 131.9, 138.4, 138.8, 146.5, 147.4, 166.2, 169.3, 169.6,
203.7

I-213

MS (FAB): 870+ (M + H +). HRMS (FAB): calcd for C45H68N5O12 870.4864 found 870.4879
Anal Calcd for C45H67N5O12 (H2O) 0.5: C 61.49, H 7.80, N 7.97 Found C 61.48, H 7.59, N
7.80
IR (KBr): 3396, 2972, 2937, 2878, 2784, 1808, 1751, 1716, 1672, 1592, 1550, 1508, 1455,
1380, 1363, 1322, 1304, 1284, 1257, 1218, 1168, 1141, 1109, 1075, 1047, 1005, 992, 952,
923, 835, 778, 709, 695, 620, 580, 554, 530, 512, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.2, 15.6, 18.6, 19.8, 21.2, 22.3, 25.8, 28.2, 32.7,
37.9, 38.1, 40.2, 42.2, 46.2, 47.7, 49.5, 51.0, 65.9, 69.5, 70.3, 71.6, 76.2, 78.4, 78.9, 83.2,
84.8, 103.8, 105.9, 118.4, 120.9, 122.6, 131.8, 146.0, 146.5, 154.1, 166.1, 169.2, 170.4,
203.8

I-214

MS (FAB): 872+ (M + H +). HRMS (FAB): calcd for C44H66N5O13 872.4657 found 872.4661
Anal Calcd for C44H65N5O13: C 59.98, H 7.55, N 7.95 Found C 59.99, H 7.42, N 7.67
IR (KBr): 3397, 2973, 2937, 2878, 2784, 1809, 1751, 1716, 1653, 1521, 1500, 1455, 1379,
1323, 1304, 1284, 1257, 1234, 1167, 1140, 1109, 1074, 1047, 1005, 992, 954, 931, 902,
867, 834, 779, 755, 680, 621 581, 554, 512, 455, 407 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.0, 10.1, 13.0, 14.3, 15.6, 15.7, 18.6, 18.7, 19.9, 21.2, 22.2,
25.9, 28.2, 32.8, 38.1, 40.2, 42.0, 42.1, 42.8, 43.2, 47.6, 47.7, 49.6, 51.0, 65.9, 69.5, 70.3,
70.6, 70.7, 71.5, 71.6, 76.1, 76.2, 78.4, 78.5, 78.8, 79.0, 83.1, 83.2, 84.9, 103.8, 126.0,
128.6, 128.8, 129.2, 129.3, 142.4, 143.1, 144.5, 144.9, 145.0, 145.9, 146.0, 154.0, 166.1,
169.1, 169.2, 172.2, 203.8

I-215

MS (FAB): 884+ (M + H +). HRMS (FAB): calcd for C46H70N5O12 884.5021 found 884.5013
Anal Calcd for C46H69N5O12 (H2O) 0.9: C 61.37, H 7.93, N 7.78 Found C 61.35, H 7.87, N
7.68
IR (KBr): 3396, 2972, 2937, 2877, 2784 1808, 1752, 1717, 1671, 1592, 1551, 1509, 1455,
1380, 1322, 1304, 1284, 1256, 1218, 1167, 1141, 1109, 1076, 1048, 1005, 992, 953, 923,
835, 779, 709, 620, 581, 555, 512 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.2, 15.5, 15.6, 18.6, 19.8, 21.2, 22.3, 25.8, 28.2,
32.7, 38.1, 40.2, 42.1, 43.0, 47.7, 49.5, 51.0, 53.2, 65.9, 69.5, 70.3, 71.7, 76.2, 78.4, 79.0,
83.3, 84.8, 103.9, 105.6, 118.7, 120.9, 123.2, 123.3, 131.8, 146.0, 146.5, 154.1, 166.0,
169.2, 174.3, 203.8

I-216

MS (FAB): 884+ (M + H +). HRMS (FAB): calcd for C46H70N5O12 884.5021 found 884.5023
Anal Calcd for C46H69N5O12 (H2O) 1.1: C 61.13, H 7.94, N 7.75 Found C 61.08, H 7.77, N
7.62
IR (KBr): 3402, 2972, 2937, 2878, 2784, 1808, 1751, 1716, 1671, 1592, 1551, 1507, 1455,
1419, 1380, 1322, 1304, 1284, 1256, 1218, 1167, 1141, 1109, 1076, 1048, 1005, 993, 953,
924, 778, 709, 620, 581, 513, 457 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.2, 15.6, 15.7, 18.6, 19.8, 21.2, 22.4, 25.8, 28.2,
32.8, 38.2, 40.2, 41.9, 42.6, 47.6, 49.5, 51.0, 52.8, 65.9, 69.5, 70.3, 71.9, 76.4, 78.4, 78.9,
83.3, 84.8, 103.8, 106.2, 118.7, 120.7, 122.6, 123.4, 131.8, 132.0, 146.0, 146.4, 154.1,
166.2, 169.1, 174.3, 203.8

I-217

MS (FAB): 854+ (M + H +). HRMS (FAB): calcd for C44H64N5O12 854.4551 found 854.4550
Anal Calcd for C44H63N5O12 (H2O) 0.9: C 60.73, H 7.51, N 8.05 Found C 60.71, H 7.35, N
7.80
IR (KBr): 3400, 2973, 2937, 2878, 2784, 1807, 1752, 1717, 1670, 1628, 1507, 1455, 1378,
1325, 1304, 1285, 1257, 1233, 1220, 1167, 1142, 1109, 1075, 1047, 1006, 991, 955, 932,
913, 903, 866, 831, 780, 754, 693, 622, 581, 563, 527, 454, 408 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 13.1, 14.3, 15.6, 15.8, 18.7, 19.9, 21.2, 22.3, 25.9, 28.2,
32.8, 38.2, 40.2, 42.5, 47.7, 49.6, 51.0, 65.9, 69.5, 70.3, 72.0, 76.2, 78.4, 78.8, 83.4, 85.0,
96.13, 103.8, 124.2, 128.9, 129.7, 130.1, 137.5, 139.7, 143.3, 143.5, 144.9, 145.3, 154.3,
165.8, 166.1, 169.1, 203.9

I-218

MS (FAB): 870+ (M + H +). HRMS (FAB): calcd for C45H68N5O12 870.4864 found 870.4874
Anal Calcd for C45H67N5O12 (H2O) 0.6: C 61.36, H 7.80, N 7.95 Found C 61.65, H 7.69, N
7.65
IR (KBr): 3396, 3070, 2972, 2937, 2878, 2784, 1806, 1751, 1716, 1671, 1601, 1558, 1544,
1515, 1455, 1425, 1379, 1322, 1304, 1284, 1257, 1219, 1168, 1141, 1109, 1075, 1047,
1005, 992, 953, 930, 914, 830, 782, 755, 738, 695, 620, 530, 455, 430, 404 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.2, 15.6, 18.6, 19.8, 21.1, 22.3, 25.8, 28.2, 32.7,
37.7, 38.1, 40.2, 42.2, 46.2, 47.7, 49.5, 51.0, 65.8, 69.5, 70.3, 71.6, 76.2, 78.4, 78.9, 83.2,
84.9, 103.8, 106.1, 119.3, 119.8, 121.6, 122.8, 143.6, 149.7, 154.1, 166.1, 169.2, 170.2,
203.7

I-219

MS (FAB): 857+ (M + H +). HRMS (FAB): calcd for C43H65N6O12 857.4660 found 857.4664
Anal Calcd for C43H64N6O12 (H2O) 0.9: C 59.15, H 7.60, N 9.62 Found C 59.15, H 7.50, N
9.47
IR (KBr): 3397, 2972, 2937, 2878, 2784, 1808, 1751, 1716, 1682, 1605, 1583, 1515, 1482,
1455, 1406, 1379, 1360, 1316, 1284, 1256, 1234, 1216, 1167, 1141, 1109, 1076, 1047,
1005, 992, 953, 931, 915, 827, 770, 753, 693, 621, 556, 529, 455, 433 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.3, 15.6, 18.6, 19.8, 21.2, 22.4, 25.9, 28.2, 32.9,
38.2, 40.2, 41.3, 47.6, 47.7, 49.6, 51.1, 65.9, 69.5, 70.3, 71.9, 76.3, 78.4, 79.0, 83.2, 84.9,
103.8, 106.0, 116.0, 131.6, 133.4, 141.2, 143.6, 144.7, 145.0, 154.3, 165.9, 169.1, 170.0,
203.9

I-220

MS (FAB): 843+ (M + H +). HRMS (FAB): calcd for C44H67N4O12 843.4755 found 843.4764
Anal Calcd for C44H66N4O12 (H2O) 0.4: C 62.16, H 7.92, N 6.59 Found C 62.19, H 8.01, N
6.45
IR (KBr): 3397, 3053, 2972, 2937, 2878, 2784, 1809, 1751, 1717, 1671, 1512, 1456, 1380,
1361, 1313, 1284, 1258, 1233, 1168, 1141, 1109, 1075, 1047, 1005, 992, 953, 931, 914,
835, 765, 742, 717, 694, 622, 581, 556, 513, 455, 427 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.1, 14.2, 15.5, 15.6, 18.6, 19.8, 21.2, 22.3, 25.8, 28.2,
32.7, 36.8, 38.2, 40.2, 41.9, 42.6, 47.7, 49.6, 51.0, 65.9, 69.5, 70.3, 71.6, 76.3, 78.4, 79.0,
83.2, 84.7, 101.1, 103.8, 109.7, 119.1, 120.6, 121.2, 128.2, 128.5, 128.6, 136.0, 153.9,
165.9, 169.1, 170.8, 203.9

I-221

MS (FAB): 909+ (M + Na +). HRMS (FAB): calcd for C46H70N4O13Na 909.4837 found
909.4839
IR (KBr): 3397, 3051, 2973, 2937, 2878, 2785, 1809, 1751, 1716, 1672, 1615, 1514, 1455,
1379, 1361, 1325, 1284, 1257, 1233, 1168, 1141, 1109, 1077, 1047, 1005, 992, 952, 931,
902, 834, 779, 742, 693, 622, 581, 563, 529, 455, 429 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.1, 14.2, 15.5, 15.7, 18.6, 19.8, 21.1, 22.2, 25.8, 28.2,
32.7, 36.6, 38.1, 40.2, 41.9, 42.3, 47.7, 49.5, 51.0, 57.0, 65.8, 66.3, 69.5, 70.2, 71.6, 76.2,
78.3, 79.0, 83.1, 84.6, 103.7, 109.8, 111.3, 119.0, 119.2, 121.6, 127.7, 128.3, 136.5, 153.8,
165.9, 169.0, 170.6, 203.8

I-222

MS (FAB): 845+ (M + H +). HRMS (FAB): calcd for C42H65N6O12 845.4660 found 845.4666
Anal Calcd for C42H64N6O12 (H2O) 0.5: C 59.07, H 7.67, N 9.84 Found C 59.15, H 7.75, N
9.59
IR (KBr): 3396, 3057, 2973, 2938, 2878, 2784, 1807, 1751, 1716, 1671, 1599, 1584, 1502,
1455, 1410, 1380, 1362, 1322, 1301, 1286, 1257, 1234, 1196, 1167, 1141, 1109, 1075,
1047, 1005, 992, 953, 931, 913, 835, 801, 776, 755, 692, 634, 512, 456 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.2, 15.6, 18.6, 19.8, 21.1, 22.2, 25.8, 28.2, 32.8,
35.6, 38.1, 39.7, 40.2, 41.9, 47.7, 49.5, 51.0, 65.8, 69.5, 70.3, 71.6, 76.1, 78.4, 78.9, 83.0,
84.7, 103.8, 117.9, 127.5, 135.3, 143.9, 145.0, 147.0, 153.8, 165.9, 169.2, 170.1, 203.8

I-223

MS (FAB): 845+ (M + H +). HRMS (FAB): calcd for C42H65N6O12 845.4660 found 845.4664
Anal Calcd for C42H64N6O12 (H2O) 0.8: C 58.70, H 7.69, N 9.78 Found C 58.76 H 7.73, N
9.58
IR (KBr): 3396, 3056, 2973, 2938, 2878, 2784, 1806, 1750, 1716, 1671, 1611, 1517, 1494,
1455, 1415, 1380, 1361, 1320, 1291, 1258, 1233, 1167, 1141, 1109, 1075, 1047, 1005,
992, 953, 932, 903, 835, 780, 755, 692, 626, 582, 566, 512, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.2, 15.5, 15.6, 18.5, 19.8, 21.1, 22.2, 25.8, 28.2,
32.6, 36.0, 38.1, 40.2, 41.5, 42.1, 47.7, 49.5, 51.0, 65.8, 69.5, 70.3, 71.4, 76.1, 78.4, 79.0,
83.3, 84.9, 103.8, 117.8, 118.5, 126.1, 144.5, 146.0, 154.0, 156.2, 166.2, 169.3, 169.6,
203.7

I-224

MS (FAB): 844+ (M + H +). HRMS (FAB): calcd for C43H66N5O12 844.4708 found 844.4705
Anal Calcd for C43H65N5O12 (H2O) 0.7: C 60.29, H 7.81, N 8.18 Found C 60.27, H 7.85, N
8.02
IR (KBr): 3396, 3058, 2972, 2937, 2878, 2784, 1807, 1751, 1716, 1671, 1616, 1497, 1456,
1381, 1363, 1327, 1304, 1286, 1258, 1234, 1167, 1141, 1109, 1075, 1047, 1005, 992, 952,
931, 913, 769, 745, 693, 625, 557, 512, 455, 428 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.1, 14.3, 15.5, 18.6, 19.8, 21.2, 22.3, 25.8, 28.3, 32.7,
36.1, 38.2, 40.2, 41.1, 42.2, 47.7, 49.5, 51.0, 65.9, 69.5, 70.3, 71.6, 76.2, 78.4, 79.0, 83.2,
84.8, 103.9, 110.1, 120.0, 121.8, 122.7, 133.8, 143.7, 143.8, 154.0, 166.2, 169.2, 170.0,
203.8

I-225

MS (FAB): 844+ (M + H +). HRMS (FAB): calcd for C43H66N5O12 844.4708 found 844.4714
Anal Calcd for C43H65N5O12 (H2O) 0.4: C 60.67, H 7.79, N 8.23 Found C 60.75, H 7.84, N
8.09
IR (KBr): 3396, 3052, 2972, 2938, 2878, 2784, 1808, 1751, 1716, 1671, 1593, 1569, 1510,
1455, 1428, 1380, 1361, 1304, 1284, 1258, 1233, 1168, 1141, 1109, 1075, 1047, 1005,
992, 953, 931, 914, 894, 835, 798, 774, 722, 693, 622, 580, 555, 530, 512, 485, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.2, 15.5, 15.6, 18.6, 19.8, 21.1, 22.2, 25.9, 28.2,
32.8, 36.6, 38.1, 40.2, 40.8, 41.4, 47.7, 49.5, 51.0, 65.8, 69.5, 70.3, 71.6, 76.2, 78.4, 79.0,
82.9, 84.6, 99.2, 103.8, 115.4, 120.6, 128.4, 128.6, 142.4, 147.3, 153.9, 165.7, 169.1,
170.7, 203.9

I-226

MS (FAB): 884+ (M + H +). HRMS (FAB): calcd for C46H70N5O12 884.5021 found 884.5021
Anal Calcd for C46H69N5O12 (H2O): C 61.25, H 7.93, N 7.76 Found C 61.25, H 7.60, N
7.55
IR (KBr): 3396, 2973, 2937, 2878, 2784, 1807, 1751, 1717, 1671, 1592, 1569, 1550, 1514,
1455, 1419, 1380, 1361, 1323, 1303, 1285, 1257, 1234, 1213, 1168, 1141, 1109, 1075,
1046, 1005, 991, 953, 924, 899, 835, 778, 709, 695, 623, 581, 530, 513, 456 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.3, 15.6, 18.6, 19.8, 21.2, 21.5, 22.4, 25.8, 28.2,
32.7, 38.2, 40.2, 42.2, 44.9, 47.7, 49.5, 51.1, 53.6, 65.9, 69.5, 70.3, 71.7, 76.3, 78.5, 78.9,
83.4, 84.9, 103.9, 105.4, 116.4, 120.6, 121.1, 123.4, 131.8, 132.2, 145.9, 146.6, 154.2,
166.0, 169.3, 170.3, 203.8

I-227

MS (FAB): 884+ (M + H +). HRMS (FAB): calcd for C46H70N5O12 884.5021 found 884.5013
Anal Calcd for C46H69N5O12 (H2O) 1.1: C 61.13, H 7.94, N 7.75 Found C 61.14, H 7.72, N
7.60
IR (KBr): 3396, 2973, 2937, 2878, 2784, 1807, 1751, 1717, 1671, 1592, 1550, 1513, 1455,
1419, 1380, 1361, 1323, 1303, 1284, 1256, 1234, 1214, 1168, 1141, 1109, 1076, 1047,
1005, 991, 953, 924, 901, 835, 778, 709, 695, 622, 555, 529, 512, 454, 432 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.1, 13.9, 14.3, 15.5, 15.7, 18.6, 19.4, 19.8, 21.2, 21.4,
21.5, 22.3, 25.8, 28.3, 32.8, 38.2, 40.2, 42.3, 44.4, 47.6, 49.5, 51.0, 53.0, 65.9, 69.5, 70.3,
71.7, 76.3, 78.4, 78.9, 83.3, 84.9, 103.8, 105.7, 116.7, 120.3, 120.5, 123.4, 131.7, 132.1,
145.9, 146.4, 154.1, 166.2, 169.1, 170.1, 203.8

I-228

MS (FAB): 884+ (M + H +). HRMS (FAB): calcd for C46H70N5O12 884.5021 found 884.5018
Anal Calcd for C46H69N5O12 (H2O) 0.7: C 61.62, H 7.91, N 7.81 Found C 61.64, H 7.80, N
7.68
IR (KBr): 3441, 2972, 2937, 2878, 2784, 1806, 1751, 1716, 1646, 1592, 1570, 1551, 1455,
1380, 1362, 1321, 1304, 1284, 1257, 1217, 1167, 1140, 1109, 1080, 1048, 1005, 992, 953,
923, 897, 834, 779, 709, 620, 581, 528, 455, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 13.2, 14.3, 15.5, 15.7, 15.8, 18.7, 18.8, 19.8, 21.2,
22.4, 22.5, 26.2, 26.3, 28.3, 28.4, 33.0, 34.0, 35.1, 35.6, 36.4, 38.2, 40.2, 45.7, 45.8, 47.7,
47.8, 47.9, 48.4, 49.7, 49.8, 51.1, 65.9, 69.5, 70.2, 70.3, 70.9, 76.4, 78.3, 78.4, 79.0, 79.2,
82.8, 84.7, 103.8, 106.1, 106.3, 118.1, 118.3, 121.3, 122.4, 122.6, 123.5, 131.9, 146.2,
146.3, 146.5, 154.4, 164.9, 165.6, 169.1, 169.2, 170.1, 170.7, 204.0

I-229

MS (FAB): 859+ (M + H +). HRMS (FAB): calcd for C43H67N6O12 859.4817 found 859.4853
IR (KBr): 3431, 3050, 2972, 2937, 2878, 2785, 1805, 1750, 1716, 1645, 1571, 1492, 1455,
1414, 1380, 1361, 1318, 1290, 1258, 1233, 1219, 1167, 1141, 1110, 1079, 1048, 1005,
992, 953, 933, 897, 834, 780, 755, 694, 631, 589, 566, 512, 455, 427 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.4, 13.0, 13.1, 13.9, 14.3, 15.4, 15.6, 18.7, 18.9, 19.4, 19.8,
21.2, 22.4, 26.2, 26.3, 28.5, 33.0, 33.2, 33.6, 34.1, 36.4, 38.1, 38.2, 40.3, 40.9, 41.0, 47.7,
47.9, 48.3, 49.7, 51.1, 65.9, 69.5, 69.8, 70.3, 70.6, 70.7, 76.3, 76.4, 78.4, 78.5, 78.8, 79.2,
82.8, 82.9, 84.7, 84.9, 103.7, 117.9, 118.5, 126.0, 126.2, 144.6, 144.8, 146.1, 146.5, 154.4,
154.6, 156.2, 165.1, 165.7, 169.2, 169.3, 169.4, 170.1, 204.0

I-230

MS (FAB): 868+ (M + H +). HRMS (FAB): calcd for C45H66N5O12 868.4708 found 868.4716
Anal Calcd for C45H65N5O12 (H2O): C 61.00, H 7.62, N 7.90 Found C 60.97, H 7.38, N
7.80
IR (KBr): 3398, 2972, 2937, 2878, 2784, 1809, 1752, 1717, 1668, 1619, 1516, 1501, 1455,
1379, 1324, 1304, 1284, 1257, 1232, 1167, 1140, 1109, 1075, 1047, 1005, 992, 952, 931,
892, 865, 826, 771, 693, 657, 622, 552, 530, 455, 433, 407 (cm-1)
13C-NMR (CDCl3): δ (ppm) 9.9, 10.3, 13.1, 14.2, 14.3, 15.5, 15.7, 15.8, 17.5, 17.7, 18.6, 19.8,
19.9, 21.1, 22.0, 22.3, 24.9, 25.8, 25.9, 26.2, 28.1, 32.7, 32.8, 38.1, 40.2, 42.3, 42.4, 47.5,
47.6, 49.4, 49.6, 50.9, 51.0, 65.7, 69.4, 70.1, 71.6, 71.8, 75.8, 76.2, 78.2, 78.3, 78.8, 83.0,
84.5, 84.6, 103.5, 103.6, 125.8, 125.9, 128.5, 128.6, 128.9, 141.5, 141.6, 142.8, 142.9,
143.5, 143.6, 144.0, 144.1, 144.6, 144.7, 153.5, 153.6, 165.6, 165.7, 168.5, 168.8, 171.5,
171.6, 203.5

I-231

MS (FAB): 868+ (M + H +). HRMS (FAB): calcd for C45H66N5O12 868.4708 found 868.4706
Anal Calcd for C45H65N5O12 (H2O) 1.2: C 60.75, H 7.64, N 7.87 Found C 60.71, H 7.38, N
7.71
IR (KBr): 3398, 2972, 2937, 2877, 2784, 1805, 1752, 1716, 1678, 1629, 1594, 1559, 1497,
1455, 1365, 1321, 1284, 1257, 1217, 1167, 1141, 1109, 1075, 1047, 1006, 992, 953, 932,
918, 837, 779, 709, 678, 620, 599, 582, 530,456, 434, 417 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 13.1, 14.2, 15.6, 15.8, 18.7, 19.9, 21.2, 22.3, 25.9, 28.2,
32.8, 38.2, 40.2, 42.5, 47.7, 49.6, 51.1, 65.9, 69.6, 70.3, 72.0, 76.3, 78.4, 78.9, 83.6, 85.0,
103.8, 106.6, 109.3, 116.8, 122.7, 123.5, 124.2, 130.7, 132.3, 137.5, 146.9, 147.1, 154.4,
165.9, 166.3, 169.1, 203.9

I-232

MS (FAB): 868+ (M + H +). HRMS (FAB): calcd for C45H66N5O12 868.4708 found 868.4712
IR (KBr): 3396, 3145, 2972, 2937, 2877, 2784, 1807, 1751, 1716, 1672, 1635, 1595, 1559,
1497, 1455, 1367, 1323, 1284, 1258, 1219, 1169, 1141, 1108, 1076, 1047, 1005, 993, 953,
932, 919, 902, 800, 781, 709, 620, 602, 513, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.2, 14.3, 15.6, 15.7, 18.7, 19.4, 19.8, 21.2, 22.4, 25.9,
28.2, 32.9, 38.2, 40.2, 42.0, 47.7, 49.6, 51.1, 65.9, 69.5, 70.3, 71.8, 76.3, 78.4, 79.0, 83.4,
84.8, 103.8, 106.5, 108.6, 120.6, 123.2, 123.4, 125.4, 131.0, 132.5, 132.8, 146.9, 147.0,
154.1, 164.7, 166.3, 169.1, 203.8

I-233

MS (FAB): 890+ (M + H +). HRMS (FAB): calcd for C41H62N3O12Cl2S 890.3431 found
890.3431
IR (KBr): 3400, 2973, 2937, 2878, 2784, 1808, 1752, 1716, 1675, 1565, 1515, 1455, 1439,
1381, 1361, 1322, 1304, 1284, 1258, 1233, 1196, 1166, 1109, 1075, 1046, 1005, 992, 953,
931, 899, 835, 777, 696, 622, 514, 451, 436, 426, 417, 408 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 13.9, 14.3, 15.6, 15.7, 18.7, 19.4, 19.8, 21.2, 22.4,
26.0, 28.2, 33.0, 36.5, 38.2, 40.2, 41.6, 47.7, 49.7, 51.1, 65.9, 69.6, 70.3, 71.8, 76.3, 78.4,
78.9, 83.2, 84.8, 103.8, 125.3, 127.0, 127.6, 130.0, 133.2, 138.4, 154.1, 166.1, 168.0,
169.1, 204.0

I-234

MS (FAB): 792+ (M + H +). HRMS (FAB): calcd for C40H62N3O13 792.4283 found 792.4283
Anal Calcd for C40H61N3O13 (H2O) 0.6: C 59.85, H 7.81, N 5.23 Found C 59.85, H 7.67, N
5.32
IR (KBr): 3398, 2973, 2938, 2878, 2785, 1810, 1752, 1717, 1670, 1629, 1561, 1509, 1456,
1381, 1361, 1323, 1283, 1257, 1220, 1167, 1142, 1109, 1076, 1047, 1006, 992, 973, 953,
930, 914, 884, 856, 834, 770, 750, 693, 678, 622, 593, 554, 512, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.1, 14.3, 15.6, 15.7, 18.7, 19.9, 21.2, 22.3, 25.9, 28.2,
32.9, 38.1, 40.2, 42.2, 47.7, 49.5, 51.1, 65.9, 69.5, 70.3, 71.7, 76.2, 78.4, 78.8, 83.2, 84.7,
103.8, 111.9, 112.4, 119.2, 127.9, 143.5, 152.0, 154.0, 165.8, 166.2, 169.0, 204.0

I-235

MS (FAB): 891+ (M + H +). HRMS (FAB): calcd for C44H64N4O13Cl 891.4158 found 891.4164
Anal Calcd for C44H63N4O13Cl (H2O) 1.2: C 57.88, H 7.22, N 6.14 Cl 3.88 Found C 57.92, H
7.00, N 5.94 Cl 3.88
IR (KBr): 3430, 2973, 2938, 2878, 2785, 1810, 1752, 1716, 1669, 1608, 1569, 1519, 1455,
1380, 1361, 1305, 1283, 1257, 1232, 1169, 1141, 1109, 1076, 1048, 1005, 992, 953, 931,
900, 835, 767, 732, 693, 642, 621, 512, 458, 403 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.7, 13.1, 14.2, 15.5, 15.7, 18.8, 19.8, 21.2, 22.4, 26.1,
28.2, 32.9, 38.2, 39.7, 40.2, 47.7, 49.6, 51.1, 65.9, 69.6, 70.4, 71.5, 76.3, 78.3, 79.2, 82.7,
84.5, 103.9, 112.6, 127.3, 127.8, 130.1, 131.6, 131.7, 133.9, 154.1, 158.7, 161.6, 165.5,
169.1, 172.8, 203.9

I-236

MS (FAB): 942+ (M + H +). HRMS (FAB): calcd for C47H64N3O15S 942.4059 found 942.4055
IR (KBr): 3423, 3068, 2973, 2938, 2878, 2785, 1809, 1751, 1716, 1672, 1590, 1571, 1522,
1456, 1381, 1360, 1314, 1258, 1228, 1170, 1157, 1109, 1075, 1048, 1005, 993, 952, 928,
898, 863, 835, 763, 751, 711, 679, 670, 621, 596, 541, 478, 414 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.1, 14.3, 15.5, 15.7, 18.7, 19.8, 21.2, 22.2, 26.1, 28.2,
32.9, 38.2, 40.2, 42.3, 47.6, 49.7, 51.0, 65.9, 69.5, 70.3, 71.6, 76.3, 78.4, 79.0, 82.9, 84.6,
103.8, 123.1, 123.5, 129.2, 129.8, 130.8, 131.6, 132.2, 133.1, 134.6, 140.5, 141.1, 141.2,
153.7, 165.4, 166.6, 169.1, 178.1, 203.9

I-237

MS (FAB): 823+ (M + H +). HRMS (FAB): calcd for C40H63N4O12S1 823.4163 found 823.4164
Anal Calcd for C40H62N4O12S (H2O) 0.6: C 57.62, H 7.64, N 6.72 S 3.85 Found C 57.66, H
7.53, N 6.57 S 3.81
IR (KBr): 3412, 2972, 2937, 2878, 2784, 1810, 1751, 1716, 1662, 1577, 1556, 1517, 1455,
1391, 1360, 1301, 1257, 1233, 1166, 1140, 1109, 1076, 1048, 1005, 992, 953, 930, 834,
765, 693, 622, 529, 485, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.4, 13.1, 13.5, 14.3, 15.5, 15.6, 18.7, 19.9, 21.2, 22.3, 26.0,
28.2, 32.8, 38.2, 40.2, 42.1, 47.6, 49.8, 51.0, 65.9, 69.6, 70.3, 71.3, 76.3, 78.4, 78.8, 83.0,
84.4, 103.8, 118.4, 129.7, 135.5, 150.0, 153.6, 158.5, 166.0, 167.4, 169.0, 204.0

I-238

MS (FAB): 877+ (M + H +). HRMS (FAB): calcd for C47H65N4O12 877.4599 found 877.4603
Anal Calcd for C47H64N4O12 (H2O) 1.1: C 62.94, H 7.44, N 6.25 Found C 62.93, H 7.21, N
6.20
IR (KBr): 3430, 3060, 2973, 2937, 2877, 2784, 1810, 1751, 1716, 1664, 1517, 1455, 1380,
1361, 1322, 1288, 1257, 1232, 1166, 1110, 1076, 1047, 1004, 993, 952, 931, 865, 835,
798, 763, 692, 638, 599, 528, 433 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 13.0, 14.2, 15.5, 15.7, 18.7, 19.8, 21.2, 22.1, 26.0, 28.2,
32.8, 38.2, 40.2, 41.6, 47.7, 49.6, 51.0, 65.8, 69.5, 70.3, 72.0, 76.2, 78.4, 78.8, 82.7, 83.9,
103.8, 122.5, 125.3, 126.6, 129.6, 130.0, 141.1, 148.7, 152.5, 166.4, 167.5, 168.9, 204.1

I-239

MS (FAB): 803+ (M + H +). HRMS (FAB): calcd for C41H63N4O12 803.4442 found 803.4435
Anal Calcd for C41H62N4O12 (H2O) 0.8: C 60.25, H 7.84, N 6.85 Found C 60.29, H 7.63, N
6.47
IR (KBr): 3399, 2973, 2937, 2879, 2784, 1808, 1752, 1718, 1673, 1633, 1596, 1552, 1509,
1455, 1415, 1380, 1361, 1324, 1301, 1284, 1257, 1220, 1168, 1141, 1110, 1076, 1047,
1006, 991, 954, 933, 904, 815, 779, 755, 694, 622, 566, 512, 457, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.1, 14.2, 15.6, 15.8, 18.6, 19.9, 21.2, 22.3, 25.9, 28.2,
32.8, 38.1, 40.2, 42.5, 47.7, 49.6, 51.0, 65.8, 69.5, 70.3, 71.8, 76.1, 78.4, 78.8, 83.4, 85.0,
103.8, 122.9, 125.8, 138.4, 142.7, 150.2, 154.2, 165.3, 166.2, 169.1, 203.9

I-240

MS (FAB): 859+ (M + H +). HRMS (FAB): calcd for C39H63N4O13S2 859.3833 found 859.3846
Anal Calcd for C39H62N4O13S2 (H2O) 0.9: C 53.52, H 7.35, N 6.40 S 7.33 Found C 53.51,
H 7.20, N 6.36 S 7.21
IR (KBr): 3397, 2973, 2937, 2877, 2784, 1806, 1747, 1670, 1519, 1455, 1380, 1357, 1330,
1268, 1220, 1168, 1141, 1110, 1074, 1047, 1006, 991, 952, 931, 914, 835, 779, 755, 692,
624, 536, 497, 457, 420 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.1, 14.3, 15.6, 15.8, 18.7, 19.8, 21.2, 22.4, 25.9, 28.2,
32.5, 32.8, 35.3, 38.2, 40.2, 40.8, 42.0, 47.7, 49.6, 51.1, 65.9, 69.5, 70.3, 71.6, 76.3, 78.4,
78.9, 83.3, 84.7, 103.8, 153.9, 166.3, 169.1, 170.1, 173.7, 201.0, 203.9

I-241

MS (FAB): 884+ (M + H +). HRMS (FAB): calcd for C45H66N5O13 884.4657 found 884.4665
Anal Calcd for C45H65N5O13 (H2O) 1.7: C 59.09, H 7.54, N 7.66 Found C 59.05, H 7.37, N
7.57
IR (KBr): 3397, 3110, 2971, 2937, 2877, 2784, 1803, 1751, 1716, 1679, 1629, 1600, 1581,
1500, 1455, 1367, 1322, 1301, 1282, 1236, 1191, 1164, 1108, 1076, 1047, 1010, 993, 973,
954, 933, 904, 860, 781, 700, 673, 622, 601, 553, 511, 451, 433 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.2, 14.2, 15.6, 15.8, 18.7, 19.9, 21.2, 22.4, 25.9, 28.2,
32.8, 38.2, 40.2, 42.5, 47.7, 49.7, 51.1, 65.9, 69.6, 70.3, 72.0, 76.3, 78.5, 79.0, 83.7, 85.1,
103.8, 107.6, 109.0, 118.0, 121.7, 122.9, 123.1, 125.7, 134.5, 136.0, 136.2, 137.2, 154.5,
165.6, 166.4, 169.1, 203.9

I-242

MS (FAB): 923+ (M + H +). HRMS (FAB): calcd for C48H71N6O12 923.5130 found 923.5143
Anal Calcd for C48H70N6O12 (H2O) 0.5: C 61.85, H 7.68, N 9.02 Found C 61.88, H 7.52, N
9.00
IR (KBr): 3432, 3068, 2971, 2937, 2877, 1808, 1751, 1716, 1654, 1600, 1556, 1521, 1455,
1403, 1365, 1311, 1284, 1257, 1230, 1143, 1110, 1076, 1047, 1004, 993, 946, 898, 860,
823, 796, 767, 725, 694, 636, 622, 576, 549, 524, 451, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.4, 13.1, 14.2, 15.4, 15.8, 18.7, 19.7, 21.2, 22.4, 26.2, 28.2,
33.1, 38.2, 39.7, 40.2, 40.3, 47.7, 49.6, 51.1, 65.8, 69.4, 70.3, 71.7, 76.3, 78.4, 79.2, 82.8,
84.6, 103.7, 111.7, 115.9, 125.8, 129.3, 129.6, 131.2, 131.5, 143.4, 150.4, 153.2, 154.4,
165.0, 166.5, 169.0, 203.9

I-243

MS (FAB): 881+ (M + H +). HRMS (FAB): calcd for C43H66N4O13Cl 881.4315 found 881.4318
Anal Calcd for Anal Calcd for C43H65ClN4O13 (H2O) 0.7: C 57.77, H 7.49, N 6.27, Cl 3.97
Found C 57.76, H 7.37, N 6.24, Cl 3.96
IR (KBr): 3438, 2973, 2937, 2879, 2784, 1810, 1751, 1716, 1683, 1635, 1527, 1490, 1455,
1380, 1317, 1284, 1257, 1232, 1166, 1141, 1110, 1076, 1049, 1008, 993, 952, 931, 885,
831, 779, 755, 694, 622, 555, 514, 457 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 12.7, 13.1, 14.2, 15.5, 15.7, 18.7, 19.7, 21.1, 22.3, 26.1,
28.2, 32.9, 38.1, 39.2, 40.1, 47.6, 49.5, 51.0, 65.7, 69.4, 70.2, 71.5, 73.1, 76.1, 78.2, 79.0,
82.7, 84.5, 103.6, 127.2, 128.3, 134.0, 135.2, 153.9, 155.2, 165.0, 168.7, 169.4, 203.5

I-244

MS (FAB): 934+ (M + H +). HRMS (FAB): calcd for C50H68N3O14 934.4701 found 934.4698
Anal Calcd for C50H67N3O14 (H2O) 1.1: C 62.96, H 7.31, N 4.41 Found C 62.94, H 7.16, N
4.50
IR (KBr): 3446, 3062, 2973, 2937, 2877, 2784, 1812, 1751, 1716, 1668, 1641, 1575, 1525,
1477, 1455, 1438, 1388, 1373, 1324, 1301, 1284, 1232, 1166, 1139, 1110, 1076, 1047,
1004, 993, 952, 931, 916, 856, 833, 800, 765, 700, 622, 532, 474 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 11.6, 13.0, 14.2, 15.2, 15.5, 18.7, 19.7, 21.1, 22.1, 25.9,
28.1, 32.7, 38.0, 40.1, 41.8, 47.2, 49.3, 50.8, 65.7, 69.4, 70.1, 70.8, 76.0, 78.0, 78.3, 82.7,
84.1, 103.4, 117.4, 122.6, 124.1, 124.8, 127.9, 128.3, 128.8, 130.1, 132.9, 134.2, 152.8,
153.2, 160.1, 164.7, 165.4, 168.6, 178.0, 203.5

I-245

MS (FAB): 919+ (M + H +). HRMS (FAB): calcd for C45H71N6O12S 919.4851 found 919.4853
Anal Calcd for C45H70N6O12S (H2O) 0.9: C 57.78, H 7.74, N 8.98, S 3.43 Found C 57.81, H
7.56, N 8.71, S 3.24
IR (KBr): 3390, 2971, 2937, 2877, 2784, 1814, 1752, 1716, 1656, 1567, 1506, 1455, 1380,
1361, 1305, 1282, 1234, 1166, 1110, 1076, 1049, 1004, 993, 952, 931, 914, 867, 835, 796,
777, 694, 676, 620, 582, 541, 512, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.1, 14.3, 15.6, 15.7, 18.8, 19.9, 21.2, 22.2, 23.3, 23.5,
26.1, 28.2, 32.9, 33.6, 38.2, 40.2, 41.3, 42.2, 47.6, 49.8, 51.1, 65.9, 69.5, 70.3, 71.7, 76.3,
78.4, 79.0, 82.9, 84.3, 103.8, 116.7, 129.1, 138.4, 142.4, 149.3, 151.5, 153.4, 166.0, 167.5,
169.1, 204.0

I-246

MS (FAB): 858+ (M + H +). HRMS (FAB): calcd for C39H61N5O12ClS 858.3726 found 858.3737
IR (KBr): 3419, 2973, 2937, 2877, 2784, 1812, 1751, 1716, 1683, 1635, 1542, 1506, 1455,
1382, 1359, 1311, 1284, 1257, 1214, 1166, 1141, 1110, 1076, 1047, 1004, 993, 952, 931,
914, 902, 835, 800, 777, 746, 692, 669, 622, 553, 455, 422, 408 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.2, 14.5, 15.6, 18.8, 19.7, 21.1, 22.3, 26.0, 28.1,
33.0, 38.1, 40.1, 40.5, 47.6, 49.6, 51.0, 65.8, 69.4, 70.2, 71.5, 76.3, 78.2, 78.8, 82.7, 84.3,
103.6, 123.9, 153.4, 154.0, 158.8, 162.3, 165.6, 168.7, 169.7, 203.6

I-247

MS (FAB): 914+ (M + H +). HRMS (FAB): calcd for C47H65N3O13Cl 914.4206 found 914.4207
Anal Calcd for C47H64N3O13Cl (H2O) 0.7: C 60.89, H 7.11, N 4.53, Cl 3.82 Found C 60.83,
H 7.03, N 4.58, Cl 3.80
IR (KBr): 3436, 2973, 2938, 2879, 2786, 1812, 1752, 1708, 1616, 1488, 1455, 1380, 1305,
1282, 1257, 1232, 1218, 1168, 1110, 1072, 1049, 1014, 993, 952, 931, 898, 860, 817, 765,
721, 698, 630, 601, 580, 507, 458, 430 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 10.4, 12.9, 13.1, 13.5, 14.1, 14.3, 15.3, 15.4, 15.8, 18.8,
19.7, 19.8, 21.1, 21.2, 22.2, 22.5, 26.3, 26.6, 28.1, 32.4, 38.2, 38.3, 38.5, 39.3, 40.2, 47.5,
47.7, 49.7, 49.8, 50.9, 51.1, 65.8, 69.5, 70.3, 70.9, 76.3, 76.4, 78.3, 79.3, 82.5, 82.8, 84.2,
84.7, 90.9, 91.4, 103.7, 103.8, 122.7, 122.8, 123.2, 123.5, 127.7, 127.8, 128.6, 128.8,
129.0, 129.3, 130.1, 130.3, 132.6, 132.7, 134.1, 134.3, 137.9, 138.1, 148.7, 149.4, 153.1,
154.0, 166.1, 166.4, 167.7, 167.8, 169.0, 203.9, 204.0

I-248

MS (FAB): 866+ (M + H +). HRMS (FAB): calcd for C43H68N3O13S 866.4473 found 866.4481
Anal Calcd for C43H67N3O13S (H2O) 0.8: C 58.66, H 7.85, N 4.77, S 3.64 Found C 58.68, H
7.64, N 4.80, S 4.80
IR (KBr): 3390, 2973, 2937, 2877, 2784, 1808, 1751, 1716, 1671, 1600, 1587, 1498, 1455,
1382, 1361, 1303, 1286, 1240, 1168, 1110, 1076, 1047, 1006, 991, 952, 931, 900, 835,
800, 755, 692, 622, 555, 512, 455, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.3, 15.6, 15.7, 18.7, 19.9, 21.2, 22.4, 26.0, 28.2,
31.5, 32.9, 36.0, 38.2, 40.2, 41.7, 47.7, 49.7, 51.1, 65.9, 67.0, 69.5, 70.3, 71.7, 76.4, 78.4,
78.9, 83.2, 84.8, 103.8, 114.6, 120.8, 129.4, 154.0, 158.5, 166.0, 169.0, 169.8, 204.0

I-249

MS (FAB): 792+ (M + H +). HRMS (FAB): calcd for C39H62N5O12 792.4395 found 792.4395
Anal Calcd for C39H61N5O12 (H2O) 0.6: C 58.35, H 7.81, N 8.72 Found C 58.32, H 7.60, N
8.63
IR (KBr): 3407, 2973, 2937, 2879, 2784, 1810, 1751, 1716, 1679, 1581, 1525, 1475, 1455,
1380, 1361, 1324, 1301, 1282, 1232, 1220, 1168, 1141, 1110, 1076, 1047, 1031, 1004,
993, 952, 931, 900, 835, 800, 779, 755, 692, 622, 582, 526, 455, 408 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.4, 13.1, 14.2, 15.3, 15.6, 18.8, 19.7, 21.1, 21.7, 22.3, 22.4,
26.2, 28.2, 33.0, 38.1, 39.9, 40.1, 47.6, 49.5, 51.0, 65.7, 69.3, 70.2, 71.5, 76.2, 78.2, 78.9,
82.7, 84.4, 103.6, 141.6, 142.2, 142.8, 154.0, 156.5, 163.2, 165.2, 168.7, 203.6

I-250

MS (FAB): 866+ (M + H +). HRMS (FAB): calcd for C47H68N3O12 866.4803 found 866.4799
Anal Calcd for C47H67N3O12 (H2O) 0.9: C 63.98, H 7.86, N 4.76 Found C 63.99, H 7.56, N
4.78
IR (KBr): 3401, 3060, 3025, 2973, 2937, 2877, 2784, 1810, 1752, 1716, 1677, 1600, 1583,
1496, 1455, 1380, 1361, 1322, 1305, 1284, 1257, 1232, 1218, 1168, 1141, 1110, 1076,
1047, 1004, 991, 952, 931, 916, 835, 777, 746, 701, 632, 582, 553, 511, 476, 457,
431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.2, 15.6, 18.6, 19.7, 21.1, 22.4, 25.8, 28.2, 32.8,
38.1, 40.1, 41.8, 47.6, 49.4, 51.0, 57.2, 65.8, 69.3, 70.1, 71.8, 76.2, 78.2, 78.6, 83.1, 84..6,
103.5, 126.4, 126.5, 128.0, 128.1, 128.2, 128.7, 140.0, 140.1, 153.8, 165.6, 168.5, 171.7,
203.6

I-251

MS (FAB): 909+ (M + H +). HRMS (FAB): calcd for C47H65N4O12S 909.4320 found 909.4326
Anal Calcd for C47H64N4O12S (H2O) 0.6: C 61.37, H 7.14, N 6.09, S 3.49 Found C 61.39, H
7.01, N 5.99, S 3.36
IR (KBr): 3421, 3060, 2973, 2937, 2877, 2784, 2223, 1810, 1751, 1716, 1660, 1585, 1509,
1457, 1380, 1361, 1322, 1301, 1284, 1257, 1232, 1166, 1141, 1110, 1076, 1047, 1006,
993, 952, 931, 835, 757, 694, 674, 622, 578, 557, 528, 458 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.4, 13.0, 14.2, 15.5, 15.7, 18.7, 19.8, 21.1, 22.2, 26.0, 28.2,
32.8, 38.1, 40.1, 41.8, 47.6, 49.6, 50.9, 65.7, 69.4, 70.2, 71.2, 76.1, 78.3, 78.8, 82.7, 84.2,
103.6, 113.9, 116.7, 126.7, 127.8, 128.2, 130.2 131.6, 132.1, 132.8, 133.2, 138.9, 141.1,
153.2, 165.5, 167.5, 168.8, 203.4

I-252

MS (FAB): 873+ (M + H +). HRMS (FAB): calcd for C44H65N4O14 873.4497 found 873.4504
Anal Calcd for C44H64N4O14 (H2O) 0.6: C 59.80, H 7.44, N 6.34 Found C 59.81, H 7.19, N
6.07
IR (KBr): 3421, 2973, 2938, 2879, 2784, 1810, 1751, 1718, 1685, 1521, 1455, 1384, 1328,
1303, 1284, 1257, 1234, 1168, 1110, 1076, 1047, 1004, 993, 952, 931, 914, 883, 835, 777,
723, 694, 622, 530, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 10.4, 13.1, 13.2, 14.2, 15.5, 15.6, 15.8, 18.7, 18.8, 19.8,
21.1, 22.3, 22.4, 26.0, 28.2, 32.9, 38.2, 40.1, 41.0, 47.6, 47.7, 49.5, 49.6, 49.8, 51.0, 51.1,
65.8, 69.4, 70.2, 71.5, 71.8, 76.2, 78.2, 78.3, 78.8, 79.0, 82.0, 83.0, 84.5, 103.6, 103.7,
123.1, 131.8, 133.6, 153.7, 153.8, 165.5, 165.7, 167.6, 168.6, 168.8, 169.3, 169.4, 203.5,
203.7

I-253

MS (FAB): 879+ (M + H +). HRMS (FAB): calcd for C43H67N4O13S 879.4425 found 879.4421
Anal Calcd for C43H66N4O13S (H2O) 1.0: C 57.57, H 7.64, N 6.25, S 3.57 Found C 57.54, H
7.41, N 6.27, S 3.62
IR (KBr): 3424, 2973, 2937, 2879, 2784, 1808, 1751, 1679, 1515, 1490, 1455, 1380, 1284,
1234, 1166, 1141, 1110, 1076, 1047, 1006, 993, 952, 931, 852, 835, 800, 779, 750, 696,
620, 512, 455, 406 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 10.3, 13.0, 13.1, 14.2, 15.4, 15.6, 15.7, 18.6, 19.8, 21.1,
22.2, 25.8, 28.2, 32.7, 34.7, 34.8, 36.6, 36.8, 38.1, 40.1, 40.9, 42.2, 42.3, 47.5, 47.6, 49.4,
49.5, 50.9, 65.7, 69.4, 70.2, 71.6, 75.9, 76.0, 78.2, 78.3, 78.7, 78.8, 82.9, 83.0, 84.7, 84.8,
103.6, 103.7, 125.0, 125.1, 126.3, 126.4, 126.5, 126.6, 138.3, 138.4, 153.5, 153.6, 165.9,
166.0, 168.8, 169.0, 172.4, 172.5, 172.6, 172.7, 203.3, 203.4

I-254

MS (FAB): 1059+ (M + H +). HRMS (FAB): calcd for C40H61N4O13I2 1059.2325 found
1059.2317
IR (KBr): 3397, 3131, 3079, 2971, 2937, 2877, 2784, 1803, 1751, 1691, 1617, 1519, 1455,
1378, 1324, 1303, 1284, 1257, 1213, 1166, 1141, 1108, 1074, 1047, 1006, 993, 952, 931,
900, 835, 779, 754, 719, 694, 622, 586, 553, 455, 418, 404 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.3, 15.6, 15.9, 18.6, 19.9, 21.2, 22.2, 26.0, 28.3,
32.8, 38.2, 40.2, 42.5, 47.7, 49.7, 51.0, 57.2, 65.8, 69.6, 70.3, 71.4, 76.1, 78.6, 79.0, 83.4,
85.5, 86.2, 103.9, 146.0, 154.4, 165.1, 166.7, 169.6, 170.9, 203.6

I-255

MS (FAB): 908+ (M + H +). HRMS (FAB): calcd for C48H82N3O13 908.5847 found 908.5853
Anal Calcd for C48H81N3O13 (H2O) 0.8: C 62.49, H 9.02, N 4.55 Found C 62.42, H 8.69, N
4.42
IR (KBr): 3401, 2937, 2867, 2784, 1812, 1752, 1704, 1671, 1509, 1455, 1380, 1361, 1322,
1303, 1284, 1257, 1234, 1166, 1141, 1110, 1076, 1047, 1004, 993, 952, 931, 914, 835,
777, 694, 622, 555, 528, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 10.2, 13.1, 14.3, 15.5, 15.7, 18.7, 19.8, 21.1, 21.8, 22.2,
22.3, 22.4, 23.4, 23.7, 23.8, 24.0, 25.7, 25.8, 26.0, 26.1, 26.7, 26.8, 28.2, 29.2, 29.3, 32.8,
33.7, 33.8, 37.0, 37.3, 38.1, 40.1, 41.7, 41.8, 47.5, 47.6, 49.4, 49.5, 51.0, 51.2, 51.3, 65.8,
69.4, 70.2, 71.7, 76.1, 78.2, 78.8, 82.9, 83.0, 84.5, 103.6, 153.5, 153.6, 165.5, 165.6, 168.8,
172.6, 172.7, 203.5, 203.6, 213.8, 213.9

I-256

MS (FAB): 816+ (M + H +). HRMS (FAB): calcd for C43H66N3O12 816.4647 found 816.4655
Anal Calcd for C43H66N3O13 (H2O) 0.85: C 62.13, H 8.09, N 5.05 Found C 62.43, H 7.80, N
4.75
IR (KBr): 3434, 3056, 2973, 2937, 2879, 2784, 1810, 1751, 1716, 1666, 1600, 1511, 1455,
1380, 1361, 1324, 1301, 1284, 1257, 1232, 1218, 1166, 1141, 1110, 1078, 1047, 1004,
993, 952, 931, 898, 835, 769, 754, 703, 634, 541, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.1, 14.2, 15.3, 15.5, 15.8, 18.8, 19.7, 21.2, 22.3,
26.1, 28.3, 30.3, 33.0, 38.0, 39.4, 40.1, 47.7, 49.5, 51.0, 65.7, 69.3, 70.2, 71.5, 76.2, 78.2,
79.0, 82.5, 84.5, 103.5, 127.6, 128.7, 130.7, 139.5, 154.0, 164.7, 168.7, 173.5, 203.5

I-257

MS (FAB): 862+ (M + H +). HRMS (FAB): calcd for C42H64N5O12S 862.4272 found 862.4278
Anal Calcd for C42H63N5O12S (H2O) 0.8: C 57.56, H 7.43, N 7.99, S 3.66 Found C 57.64, H
7.29, N 7.79, S 3.56
IR (KBr): 3396, 3064, 2973, 2937, 2879, 2786, 1808, 1751, 1716, 1662, 1523, 1455, 1440,
1380, 1359, 1322, 1305, 1284, 1267, 1230, 1166, 1110, 1076, 1047, 1006, 991, 954, 931,
900, 835, 767, 744, 694, 620, 555, 528, 455, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.3, 15.5, 15.7, 18.6, 19.8, 21.1, 22.3, 25.9, 28.2,
32.9, 34.9, 38.1, 40.1, 42.6, 47.6, 49.6, 50.9, 65.7, 69.4, 70.2, 71.2, 76.1, 78.3, 78.7, 83.1,
85.0, 103.6, 110.4, 118.2, 134.8, 143.7, 150.0, 153.9, 166.2, 168.8, 170.6, 203.5

I-258

MS (FAB): 956+ (M + H +). HRMS (FAB): calcd for C54H74N3O12 956.5272 found 956.5274
Anal Calcd for C54H73N3O12 (H2O) 0.7: C 66.95, H 7.74, N 4.34 Found C 66.98, H 7.51, N
4.33
IR (KBr): 3419, 3056, 2973, 2937, 2877, 2784, 1812, 1752, 1716, 1675, 1596, 1494, 1454,
1380, 1361, 1324, 1303, 1284, 1257, 1232, 1166, 1108, 1076, 1047, 1004, 991, 952, 931,
916, 835, 800, 752, 701, 613, 528, 455 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.1, 14.2, 15.6, 18.7, 18.9, 19.7, 21.1, 22.2, 25.8, 28.1,
32.7, 38.0, 40.1, 40.7, 47.2, 47.5, 49.5, 50.9, 56.1, 65.7, 69.4, 70.1, 71.5, 76.0, 78.2, 78.8,
82.8, 84.3, 103.6, 125.6, 127.4, 129.0, 129.1, 146.6, 153.5, 164.9, 168.7, 170.1, 203.5

I-259

MS (FAB): 878+ (M + H +). HRMS (FAB): calcd for C48H68N3O12 878.4803 found 878.4801
Anal Calcd for C48H87N3O12 (H2O) 0.9: C 64.47, H 7.75, N 4.70 Found C 64.29, H 7.46, N
4.51
IR (KBr): 3407, 3066, 2973, 2937, 2877, 2784, 1810, 1751, 1716, 1671, 1513, 1452, 1380,
1361, 1322, 1303, 1284, 1257, 1232, 1166, 1110, 1076, 1047, 1004, 993, 952, 931, 914,
863, 835, 761, 744, 692, 620, 580, 559, 528, 455, 426 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.2, 15.5, 15.6, 18.7, 19.8, 21.1, 22.2, 25.9, 28.2,
32.8, 38.1, 40.0, 40.1, 41.3, 43.9, 47.5, 49.5, 50.9, 65.8, 69.4, 70.2, 71.7, 76.1, 78.2, 78.8,
82.7, 84.2, 103.6, 119.4, 124.2, 124.4, 126.6, 126.7, 126.8, 140.5, 140.6, 146.6, 146.7,
153.2, 165.4, 168.6, 171.4, 203.5

I-260

MS (FAB): 880+ (M + H +). HRMS (FAB): calcd for C47H66N3O13 880.4596 found 880.4587
Anal Calcd for C47H85N3O13 (H2O) 1.0: C 62.86, H 7.52, N 4.68 Found C 62.85, H 7.25, N
4.38
IR (KBr): 3415, 3062, 2973, 2937, 2877, 2784, 1810, 1751, 1716, 1664, 1600, 1579, 1517,
1455, 1380, 1361, 1319, 1303, 1282, 1259, 1168, 1141, 1110, 1076, 1047, 993, 954, 931,
833, 798, 771, 755, 715, 696, 667, 640, 622, 528, 453 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.0, 14.2, 15.5, 15.6, 18.7, 19.8, 21.1, 22.3, 26.0, 28.2,
32.8, 38.1, 40.1, 42.3, 47.5, 49.5, 50.9, 65.8, 69.4, 70.2, 71.2, 76.1, 78.3, 78.7, 82.8, 84.4,
103.6, 128.1, 128.2, 129.1, 129.9, 130.7, 132.1, 132.2, 134.6, 137.3, 137.8, 153.5, 165.7,
167.2, 168.6, 195.8, 203.4

I-261

MS (FAB): 854+ (M + H +). HRMS (FAB): calcd for C42H62ClFN3O12 854.4006 found 854.4018
Anal Calcd for C42H81N3O12FCl (H2O) 0.4: C 58.55, H 7.23, N 4.88 F 2.20 Cl 4.11 Found C
58.29, H 7.01, N 5.18 F 2.15 Cl 4.26
IR (KBr): 3390, 3081, 2973, 2937, 2877, 2784, 1812, 1752, 1716, 1671, 1627, 1600, 1562,
1509, 1455, 1380, 1361, 1324, 1284, 1249, 1234, 1216, 1201, 1168, 1141, 1110, 1076,
1047, 1006, 991, 954, 931, 914, 865, 835, 782, 748, 694, 622, 559, 511, 431 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.3, 15.5, 15.7, 18.6, 19.8, 21.1, 22.3, 25.9, 28.3,
32.9, 38.1, 40.1, 42.3, 47.5, 49.4, 51.0, 65.8, 69.4, 70.2, 71.2, 76.0, 78.3, 78.4, 82.9, 84.6,
103.6, 114.2, 114.5, 122.3, 122.5, 125.4, 125.5, 127.6, 127.8, 129.3, 129.4, 130.7, 135.7,
135.8, 153.5, 159.8, 163.2, 165.4, 165.6, 168.7, 203.6

I-262

MS (FAB): 881+ (M + H +). HRMS (FAB): calcd for C47H69N4O12 881.4912 found 881.4904
Anal Calcd for C47H68N4O12 (H2O) 0.5: C 63.42, H 7.81, N 6.29 Found C 63.39, H 7.70, N
6.18
IR (KBr): 3432, 3060, 2971, 2937, 2877, 2784, 1812, 1751, 1716, 1662, 1579, 1517, 1492, 1455, 1380, 1359, 1324, 1303, 1284, 1255, 1232, 1166, 1141 , 1110, 1076, 1047, 1004, 993, 952, 931, 890, 833, 767, 682, 622, 528, 457 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.1, 14.2, 15.4, 15.6, 18.7, 19.8, 21.2, 22.2, 22.5, 22.8, 26.0, 26.4, 28.2, 32.8, 33.9, 38.2, 40.2, 41.2, 47.6 , 49.6, 51.0, 65.9, 69.5, 70.3, 71.9, 76.3, 78.4, 78.8, 82.8, 84.1, 103.8, 123.5, 124.1, 126.3, 126.8, 128.5, 128.6, 141.1, 146.2, 152.9,
159.5, 166.3, 168.1, 168.9, 204.1

I-263

MS (FAB): 876+ (M + H +). HRMS (FAB): calcd for C48H66N3O12 876.4646 found 876.4645
Anal Calcd for C48H65N3O12 (H2O) 0.9: C 64.61, H 7.55, N 4.71 Found C 64.60, H 7.36, N
4.72
IR (KBr): 3438, 3054, 2973, 2937, 2877, 2784, 1810, 1751, 1716, 1660, 1560, 1508, 1455,
1380, 1361, 1322, 1303, 1286, 1255, 1232, 1166, 1141, 1110, 1076, 1047, 1004, 993, 952,
931, 889, 844, 792, 773, 734, 692, 632, 601, 555, 526, 435 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.1, 14.2, 15.3, 15.7, 18.7, 18.9, 19.7, 21.2, 22.2, 26.0,
28.2, 32.9, 38.2, 40.2, 41.0, 47.7, 49.6, 51.1, 65.8, 69.5, 69.7, 70.3, 71.9, 76.3, 78.3, 78.9,
82.7, 84.1, 103.7, 125.1, 125.2, 126.5, 128.1, 128.2, 128.4, 131.2, 132.0, 153.2, 165.9,
168.9, 169.8, 204.1

I-264

MS (FAB): 856+ (M + H +). HRMS (FAB): calcd for C41H63ClN3O12S 856.3821 found 856.3814
Anal Calcd for C41H62N3O12ClS (H2O) 0.4: C 57.02, H 7.33, N 4.87 Cl 4.10 S 3.71 Found C
56.99, H 7.20, N 4.93 Cl 4.10 S 3.79
IR (KBr): 3392, 2973, 2937, 2877, 2784, 1808, 1751, 1716, 1675, 1515, 1477, 1455, 1382,
1361, 1322, 1303, 1284, 1257, 1234, 1166, 1110, 1095, 1076, 1047, 1008, 991, 954, 931,
900, 817, 777, 755, 744, 694, 622, 538, 489, 439, 420, 408 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.3, 13.1, 14.2, 15.6, 18.6, 19.8, 21.1, 22.3, 25.9, 28.1, 32.8,
37.5, 38.0, 40.1, 41.7, 47.6, 49.5, 50.9, 65.7, 69.4, 70.1, 71.6, 76.2, 78.2, 78.7, 83.0, 84.6,
103.5, 128.7, 129.9, 131.8, 134.0, 153.7, 165.7, 168.2, 168.7, 203.6

I-265

MS (FAB): 868+ (M + H +). HRMS (FAB): calcd for C42H66N3O14S 868.4265 found 868.4270
Anal Calcd for C42H65N3O14S (H2O) 0.8: C 57.16, H 7.61, N 4.76 S 3.63 Found C 57.12, H
7.43, N 4.75, S 3.63
IR (KBr): 3390, 3064, 2973, 2937, 2879, 2784, 1810, 1751, 1716, 1675, 1585, 1515, 1455,
1380, 1363, 1309, 1286, 1257, 1234, 1155, 1110, 1074, 1047, 1006, 993, 952, 931, 912,
835, 771, 754, 734, 690, 622, 576, 547, 532, 431, 418 (cm-1)
13C-NMR (CDCl3): δ (ppm) 9.96, 13.0, 14.3, 15.4, 15.7, 18.6, 19.8, 21.1, 22.1, 25.8, 28.1,
29.0, 32.8, 38.0, 40.1, 42.4, 47.4, 49.4, 50.9, 52.1, 65.7, 69.4, 70.2, 70.9, 76.0, 78.2, 78.6,
82.9, 84.7, 103.6, 128.2, 128.9, 133.3, 138.6, 153.5, 165.8, 168.9, 169.0, 203.7

I-266

MS (FAB): 833+ (M + H +). HRMS (FAB): calcd for C42H62FN4O12 833.4348 found 833.4373
Anal Calcd for C42H61N4O12F (H2O) 0.7: C 59.66, H 7.44, N 6.63 F 2.25 Found C 59.69, H
7.35, N 6.64 F 2.15
IR (KBr): 3411, 2973, 2938, 2879, 2786, 1810, 1751, 1716, 1646, 1548, 1506, 1482, 1454,
1423, 1380, 1324, 1303, 1282, 1257, 1230, 1164, 1110, 1076, 1047, 1004, 991, 954, 933,
916, 856, 835, 800, 767, 734, 692, 619, 601, 528, 511, 478, 457, 433, 403 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.1, 13.1, 14.2, 15.6, 18.7, 19.8, 21.1, 22.3, 26.1, 28.1, 32.8,
38.1, 40.1, 41.5, 47.6, 49.6, 51.0, 65.7, 69.4, 70.2, 71.2, 76.2, 78.3, 78.9, 83.0, 84.6, 103.2,
103.3, 103.6, 106.1, 106.4, 112.6, 112.7, 112.9, 127.7, 127.8, 132.0, 133.0, 154.0, 156.1,
159.2, 161.7, 165.9, 168.7, 203.6

I-267

MS (FAB): 841+ (M + H +). HRMS (FAB): calcd for C44H65N4O12 841.4599 found 841.4600
Anal Calcd for C44H64N4O12 (H2O) 0.4: C 61.91, H 7.72, N 6.56 Found C 61.86, H 7.68, N
6.41
IR (KBr): 3403, 3058, 2973, 2937, 2877, 2784, 1808, 1751, 1716, 1656, 1614, 1577, 1506,
1455, 1380, 1361, 1328, 1305, 1280, 1251, 1234, 1166, 1139, 1110, 1074, 1047, 1006,
991, 954, 931, 914, 833, 800, 769, 744, 692, 624, 593, 553, 514, 470, 455, 424 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.0, 13.1, 14.2, 15.7, 15.8, 18.5, 19.8, 21.1, 22.1, 25.8, 28.1,
32.8, 38.0, 40.1, 41.9, 47.6, 49.4, 50.9, 65.6, 69.3, 70.2, 71.7, 76.0, 78.2, 78.7, 83.2, 84.7,
103.5, 111.4, 112.9, 115.3, 119.6, 120.3, 122.1, 125.8, 127.4, 133.9, 136.6, 154.0, 165.3,
167.4, 168.6, 203.7

VI (19)
I-268

MS (FAB): 812+ (M + H +). HRMS (FAB): calcd for C39H62N3O13S 812.4003 found 812.4001
IR (CHCl3): 3020, 3016, 2978, 2934, 1806, 1730, 1455, 1374, 1247, 1229, 1162, 1108,
1070, 1044, 990, 908 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.9, 14.0, 15.3, 15.4, 18.5, 19.6, 21.0, 22.1, 25.8, 28.0,
32.7, 37.9, 40.0, 44.5, 47.4, 49.2, 50.8, 65.5, 69.3, 70.1, 71.0, 76.2, 78.0, 78.6, 82.7, 84.3,
103.5, 126.7, 128.8, 132.2, 140.1, 153.5, 166.2, 168.8, 203.9

I-269

MS (FAB): 840+ (M + H +). HRMS (FAB): calcd for C41H66N3O13S1 840.4316 found 840.4316
IR (CHCl3): 3020, 2970, 2934, 2872, 1804, 1752, 1714, 1454, 1381, 1361, 1323, 1281,
1232, 1229, 1161, 1108, 1071, 1046, 1006, 988, 952 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.2, 15.5, 18.6, 19.7, 21.1, 22.2, 25.9, 28.1, 29.8,
32.9, 38.1, 40.1, 44.2, 47.5, 49.6, 50.9, 54.2, 65.7, 69.4, 70.2, 76.3, 78.2, 78.8, 82.8, 84.5,
103.6, 126.5, 128.3, 128.6, 138.2, 153.7, 166.1, 168.9, 203.9

I-270

MS (FAB): 826+ (M + H +). HRMS (FAB): calcd for C40H64N3O13S1 826.4160 found 826.4150
IR (CHCl3): 3341, 3025, 3019, 3015, 2977, 2939, 2880, 2838, 2788, 1804, 1752, 1717,
1602, 1495, 1455, 1407, 1382, 1362, 1328, 1282, 1258, 1225, 1221, 1211, 1162, 1109,
1072, 1048, 1007, 989, 952, 931, 914, 889, 833 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 13.0, 14.2, 15.6, 18.6, 18.7, 19.7, 21.1, 22.2, 22.3, 25.9,
28.1, 33.0, 38.1, 40.1, 44.7, 47.6, 49.6, 51.0, 59.3, 65.7, 69.4, 70.2, 72.3, 76.2, 78.2, 78.8,
82.8, 84.6, 103.6, 128.2, 128.4, 128.6, 128.9, 129.7, 130.7, 130.8, 153.9, 165.9, 168.9,
203.9

I-271

MS (FAB): 854+ (M + H +). HRMS (FAB): calcd for C41H64N3O12S2 854.3931 found 854.3923
IR (CHCl3): 3032, 2977, 2938, 1754, 1717, 1455, 1381, 1357, 1326, 1298, 1205, 1164,
1148, 1106, 1072, 1052, 989, 972, 950, 914, 862, 825 (cm-1)
13C-NMR (CDCl3): δ (ppm) 10.2, 12.7, 14.3, 15.5, 15.9, 18.8, 19.8, 21.2, 22.4, 26.2, 28.3,
33.6, 38.2, 40.2, 44.0, 47.6, 49.8, 51.0, 65.9, 69.4, 70.2, 71.8, 75.8, 78.4, 78.8, 88.0, 89.4,
103.7, 125.8, 128.3, 128.9, 130.5, 132.8, 140.8, 166.0, 168.9, 190.5, 203.9

VII (20)
I-272

MS (FAB): 701+ (M + H +). HRMS (FAB): calcd for C34H57N2O13 701.3861 found 701.3862
IR (KBr): 3439, 2975, 2937, 2879, 1804, 1752, 1717, 1593, 1457, 1409, 1382, 1363, 1314,
1283, 1238, 1165, 1142, 1111, 1082, 1049, 1005, 953, 900, 779, 691, 632, 573, 532, 512,
454, 408 (cm-1)
13C-NMR (CD3OD): δ (ppm) 10.9, 13.4, 14.7, 15.8, 16.3, 18.8, 19.1, 20.9, 21.3, 23.5, 27.6,
31.6, 39.3, 40.1, 50.3, 52.2, 66.8, 69.4, 70.6, 77.6, 79.9, 80.3, 81.0, 84.4, 86.5, 104.2,
156.1, 165.8, 171.0, 180.1, 206.0

6Bd

MS (FAB): 983+ (M + H +). HRMS (FAB): calcd for C52H75N2O16 983.5117 found 983.5123
Anal Calcd for C52H74N2O16: C 63.53, H 7.59, N 2.85 Found C 63.35, H 7.58, N 3.07
IR (KBr): 3448, 3066, 3033, 2976, 2938, 2878, 1749, 1705, 1629, 1497, 1455, 1406, 1381,
1334, 1293, 1254, 1172, 1115, 1085, 1067, 1033, 984, 959, 936, 916, 783, 767, 754, 739,
698, 614, 521, 472 (cm-1)

6Bf

MS (FAB): 997+ (M + H +). HRMS (FAB): calcd for C53H77N2O16 997.5273 found 997.5278
IR (KBr): 3438, 3066, 3033, 2974, 2938, 2877, 1749, 1706, 1629, 1497, 1455, 1406, 1381,
1333, 1254, 1172, 1115, 1068, 1033, 985, 960, 935, 918, 783, 767, 754, 698, 473 (cm-1)

6Ad

MS (FAB): 1009+ (M + H +). HRMS (FAB): calcd for C53H73N2O17 1009.4909 found
1009.4918
Anal Calcd for C53H72N2O17 (H2O) 0.4 (CHCl3) 0.13: C 61.84, H 7.12, N 2.71, Cl 1.34 Found C
61.81, H 7.12, N 2.96, Cl 1.33
IR (KBr): 3424, 3065, 3032, 2975, 2938, 2880, 1811, 1752, 1704, 1497, 1455, 1382, 1330,
1292, 1254, 1167, 1114, 1084, 1066, 989, 953, 933, 909, 782, 768, 754, 698 (cm-1)

6Af

MS (FAB): 1023+ (M + H +). HRMS (FAB): calcd for C54H75N2O17 1023.5066 found
1023.5050
IR (KBr): 3431, 3066, 3033, 2974, 2938, 2879, 1811, 1752, 1704, 1632, 1497, 1456, 1382,
1330, 1291, 1254, 1167, 1114, 1067, 991, 932, 912, 782, 768, 754, 698, 457 (cm-1)

Test example 1
The antibacterial activity of compound (I) was examined.
(Test method)
The minimum inhibitory concentration (MIC: μg / ml) is measured according to the Japanese Society of Chemotherapy Standard Method
The amount was 1000 cfu / spot, the test medium was a sensitive disk medium, and the agar plate dilution method was used.

The compound of the present invention comprises Staphylococcus aureus and pneumococci containing erythromycin-resistant bacteria (EM-R).
The same level as commercially available erythromycin derivatives or
It showed more antibacterial activity.

Test example 2
Tested for relationship between antibacterial activity and 9-position iminoether side chain length, carbamoyl group, etc.
It investigated by the method similar to Example 1.

In the 9-position iminoether type side chain part, there is a carbamoyl group etc. in the spacer part
It was found that the antibacterial activity against Haemophilus influenzae is enhanced. X is-
When NHCO-, the length of the adjacent alkylene moiety is preferably 3 (n) carbon atoms.
It was found to be ˜5, more preferably 3.

Test example 3
As the pharmacokinetics of Compound (I), lung migration in rats was examined.
(Test method)
The compound was orally administered to rats, and after 1, 3, 6 hours under ether anesthesia, the heart was collected and the lungs were removed.
It was. 4 mL of 0.1 mol / L phosphate buffer, pH8 / MeOH (1: 4) per 1 g of lung δ 0.1% Tween80
The supernatant obtained by adding and homogenizing and centrifuging was used as a tissue sample. Drugs in tissue samples
The concentration was quantified by a microbiological quantification method using Micrococcus luteus ATCC9341 as a test bacterium.

The compound of the present invention is equivalent to or more than clarithromycin, which has excellent ability to migrate into the lung.
Showed lung transferability.

Claims (16)

formula:

(Where
Me is methyl;
R ¹ is hydrogen or lower alkyl;
The wavy lines are in any configuration;
O R ^a and O R ^b are each independently hydroxy or together with adjacent 11 and 12 position moieties

A ring structure represented by :
m is 0 or 1;
X is —NR ² —CO—, —CO—NR ² —, —SO ₂ —NR ² —, or —NR ² —SO ₂ — (R ² is hydrogen or optionally substituted lower alkyl) ; Y is a single bond or may be substituted or a hetero atom may be bonded or interposed, respectively, 1) alkylene, 2) alkenylene, 3) alkynylene or 4) cycloalkylene;
Ar represents an optionally substituted carbocyclic group or an optionally substituted heterocyclic group)
Or a pharmaceutically acceptable salt or solvate thereof. m is 0, X is —NR ² —CO— (R ² is hydrogen or optionally substituted lower alkyl) , Y may be substituted, and a heteroatom may be bonded or interposed, The compound according to claim 1, which is alkylene or alkenylene, or a pharmaceutically acceptable salt or solvate thereof. 2. The method according to claim 1, wherein m is 1, R ¹ is hydrogen, and X is —CO—NR ² — or —SO ₂ —NR ² — (R ² is hydrogen or optionally substituted lower alkyl). A compound, pharmaceutically acceptable salt or solvate thereof. The compound according to any one of claims 1 to 3, wherein Y is C2-5 alkylene or C2-5 alkenylene, each of which may be substituted and O or N may be bonded or mediated. A top acceptable salt or solvate. The compound according to claim 4, a pharmaceutically acceptable salt or solvate thereof, wherein Y is a divalent group having any of the following structures which may be substituted:

Y is - _{(CH 2) 2} - or - _{(CH 2) 3} - a is 4. A compound according, a pharmaceutically acceptable salt or solvate thereof. The compound according to claim ¹ , wherein R ¹ is hydrogen, methyl or ethyl; m is 0 ; X is -NH-CO-, and Y is C3-C5 alkylene, or a pharmaceutically acceptable salt or solvate thereof. R ¹ is methyl or ethyl; m is 0; X is -NH-CO-, and Y is - _{(CH 2) 3} -, compound of claim 1, a pharmaceutically acceptable salt or solvate thereof. The compound according to claim ¹ , wherein R ¹ is hydrogen, m is 1, X is -CO-NH-, and Y is C2-C4 alkylene, or a pharmaceutically acceptable salt or solvate thereof. The compound according to claim ¹ , wherein R ¹ is hydrogen, m is 1, X is -CO-NH-, and Y is-(CH ₂ ) _2- , or a pharmaceutically acceptable salt or solvate thereof. The compound according to any one of claims 1 to 10, or a pharmaceutically acceptable salt or solvate thereof, wherein Ar is aryl or heteroaryl which may be substituted. The compound according to claim 1, wherein Ar is a 5- or 6-membered heterocyclic group containing 1 to 4 phenyl or N atoms, which may be substituted or condensed with another ring. A pharmaceutically acceptable salt or solvate thereof. A pharmaceutical composition comprising the compound according to claim 1, a pharmaceutically acceptable salt or solvate thereof. An antibacterial agent comprising the compound according to any one of claims 1 to 12, a pharmaceutically acceptable salt or solvate thereof. A compound in which the dimethylamino and / or hydroxy moiety on the 5-position side chain of the compound according to any one of claims 1 to 12, and a pharmaceutically acceptable salt or solvate thereof is protected. formula:

(Wherein each symbol has the same meaning as in claim 1)
Or a pharmaceutically acceptable salt or solvate thereof, or a compound in which a dimethylamino, hydroxy, and / or carboxy moiety thereof is protected.