WO2002042463A3 - Compositions and methods relating to prostate specific genes and proteins - Google Patents

Compositions and methods relating to prostate specific genes and proteins Download PDF

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Publication number
WO2002042463A3
WO2002042463A3 PCT/US2001/045009 US0145009W WO0242463A3 WO 2002042463 A3 WO2002042463 A3 WO 2002042463A3 US 0145009 W US0145009 W US 0145009W WO 0242463 A3 WO0242463 A3 WO 0242463A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
compositions
antagonists
nucleic acids
agonists
Prior art date
Application number
PCT/US2001/045009
Other languages
French (fr)
Other versions
WO2002042463A2 (en
Inventor
Susana Salceda
Roberto A Macina
Herve Recipon
Robert Cafferkey
Shujath Ali
Yongming Sun
Chenghua Liu
Original Assignee
Diadexus Inc
Susana Salceda
Roberto A Macina
Herve Recipon
Robert Cafferkey
Shujath Ali
Yongming Sun
Chenghua Liu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diadexus Inc, Susana Salceda, Roberto A Macina, Herve Recipon, Robert Cafferkey, Shujath Ali, Yongming Sun, Chenghua Liu filed Critical Diadexus Inc
Priority to EP01997555A priority Critical patent/EP1368471A2/en
Priority to AU2002217991A priority patent/AU2002217991A1/en
Publication of WO2002042463A2 publication Critical patent/WO2002042463A2/en
Publication of WO2002042463A3 publication Critical patent/WO2002042463A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic prostate ells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating prostate cancer and non-cancerous disease states in prostate tissue, identifying prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered prostate tissue for treatment and research.
PCT/US2001/045009 2000-11-21 2001-11-20 Compositions and methods relating to prostate specific genes and proteins WO2002042463A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01997555A EP1368471A2 (en) 2000-11-21 2001-11-20 Compositions and methods relating to prostate specific genes and proteins
AU2002217991A AU2002217991A1 (en) 2000-11-21 2001-11-20 Compositions and methods relating to prostate specific genes and proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25218800P 2000-11-21 2000-11-21
US60/252,188 2000-11-21

Publications (2)

Publication Number Publication Date
WO2002042463A2 WO2002042463A2 (en) 2002-05-30
WO2002042463A3 true WO2002042463A3 (en) 2003-07-10

Family

ID=22954965

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/045009 WO2002042463A2 (en) 2000-11-21 2001-11-20 Compositions and methods relating to prostate specific genes and proteins

Country Status (4)

Country Link
US (1) US20020127237A1 (en)
EP (1) EP1368471A2 (en)
AU (1) AU2002217991A1 (en)
WO (1) WO2002042463A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL144447A0 (en) * 2001-07-19 2002-05-23 Rappaport Family Inst For Res Anti-tumor activity from reptile serum
US7425700B2 (en) 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
US20040236603A1 (en) * 2003-05-22 2004-11-25 Biospect, Inc. System of analyzing complex mixtures of biological and other fluids to identify biological state information
US20050244973A1 (en) * 2004-04-29 2005-11-03 Predicant Biosciences, Inc. Biological patterns for diagnosis and treatment of cancer
WO2009043083A1 (en) * 2007-10-04 2009-04-09 Adelaide Research & Innovation Pty Ltd Method and composition for modulating androgen receptor activity
CN117233413A (en) 2019-08-05 2023-12-15 禧尔公司 Systems and methods for sample preparation, data generation, and protein crown analysis

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999060162A1 (en) * 1998-05-21 1999-11-25 Diadexus Llc A novel method of diagnosing, monitoring, and staging prostate cancer
WO2000044940A2 (en) * 1999-01-28 2000-08-03 Gen-Probe Incorporated Nucleic acid sequences for detecting genetic markers for cancer in a biological sample
WO2000047773A1 (en) * 1999-02-09 2000-08-17 Urocor, Inc. A novel, prostate-specific gene for diagnosis, prognosis and management of prostate cancer
WO2000058470A1 (en) * 1999-03-26 2000-10-05 Henry M. Jackson Foundation For The Advancement Of Military Medicine Prostate-specific gene, pcgem1, and methods of using pcgem1 to detect, treat, and prevent prostate cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908748B2 (en) * 1999-07-29 2005-06-21 Kenji Sobue Genes associated with the maintenance of differentiation of smooth muscle cells
WO2001009315A1 (en) * 1999-07-29 2001-02-08 Helix Research Institute Novel gene participating in the maintenance of smooth muscle cell differentiation
WO2001009316A1 (en) * 1999-07-29 2001-02-08 Helix Research Institute Novel genes encoding protein kinase/protein phosphatase
EP1287015A1 (en) * 2000-04-18 2003-03-05 Human Genome Sciences, Inc. Extracellular matrix polynucleotides, polypeptides, and antibodies

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999060162A1 (en) * 1998-05-21 1999-11-25 Diadexus Llc A novel method of diagnosing, monitoring, and staging prostate cancer
WO2000044940A2 (en) * 1999-01-28 2000-08-03 Gen-Probe Incorporated Nucleic acid sequences for detecting genetic markers for cancer in a biological sample
WO2000047773A1 (en) * 1999-02-09 2000-08-17 Urocor, Inc. A novel, prostate-specific gene for diagnosis, prognosis and management of prostate cancer
WO2000058470A1 (en) * 1999-03-26 2000-10-05 Henry M. Jackson Foundation For The Advancement Of Military Medicine Prostate-specific gene, pcgem1, and methods of using pcgem1 to detect, treat, and prevent prostate cancer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BUSSEMAKERS M J G ET AL: "DD3: NEW PROSTATE-SPECIFIC GENE, HIGHLY OVEREXPRESSED IN PROSTATE CANCER", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 59, 1 December 1999 (1999-12-01), pages 5975 - 5979, XP002923011, ISSN: 0008-5472 *
HUBERT R S ET AL: "SETAP: A PROSTATE-SPECIFIC CELL-SURFACE ANTIGEN HIGHLY EXPRESSED IN HUMAN PROSTATE TUMORS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 96, no. 25, 7 December 1999 (1999-12-07), pages 14523 - 14528, XP000946864, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2002042463A2 (en) 2002-05-30
EP1368471A2 (en) 2003-12-10
AU2002217991A1 (en) 2002-06-03
US20020127237A1 (en) 2002-09-12

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