WO2002042435A3 - Regulation of human tyrosine phosphatase - Google Patents

Regulation of human tyrosine phosphatase Download PDF

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Publication number
WO2002042435A3
WO2002042435A3 PCT/EP2001/013794 EP0113794W WO0242435A3 WO 2002042435 A3 WO2002042435 A3 WO 2002042435A3 EP 0113794 W EP0113794 W EP 0113794W WO 0242435 A3 WO0242435 A3 WO 0242435A3
Authority
WO
WIPO (PCT)
Prior art keywords
tyrosine phosphatase
human tyrosine
regulation
reagents
ameliorating
Prior art date
Application number
PCT/EP2001/013794
Other languages
French (fr)
Other versions
WO2002042435A2 (en
Inventor
Zhimin Zhu
Original Assignee
Bayer Ag
Zhimin Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Zhimin Zhu filed Critical Bayer Ag
Priority to AU2002233201A priority Critical patent/AU2002233201A1/en
Publication of WO2002042435A2 publication Critical patent/WO2002042435A2/en
Publication of WO2002042435A3 publication Critical patent/WO2002042435A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03048—Protein-tyrosine-phosphatase (3.1.3.48)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Reagents which regulate human tyrosine phosphatase and reagents which bind to human tyrosine phosphatase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, obesity, diabetes, CNS disorders, chronic obstructive pulmonary disease, cardiovascular diseases, and cancer.
PCT/EP2001/013794 2000-11-27 2001-11-27 Regulation of human tyrosine phosphatase WO2002042435A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002233201A AU2002233201A1 (en) 2000-11-27 2001-11-27 Regulation of human tyrosine phosphatase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25291200P 2000-11-27 2000-11-27
US60/252,912 2000-11-27

Publications (2)

Publication Number Publication Date
WO2002042435A2 WO2002042435A2 (en) 2002-05-30
WO2002042435A3 true WO2002042435A3 (en) 2003-01-23

Family

ID=22958065

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/013794 WO2002042435A2 (en) 2000-11-27 2001-11-27 Regulation of human tyrosine phosphatase

Country Status (2)

Country Link
AU (1) AU2002233201A1 (en)
WO (1) WO2002042435A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003033688A1 (en) * 2001-10-16 2003-04-24 Bayer Healthcare Ag Regulation of human receptor tyrosine phosphatase
WO2003050084A2 (en) * 2001-12-07 2003-06-19 Incyte Genomics, Inc. Kinases and phosphatases
WO2005113824A2 (en) * 2004-05-14 2005-12-01 Zhenghe Wang Protein tyrosine phosphatase mutations in cancers

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998049317A2 (en) * 1997-04-28 1998-11-05 Sugen, Inc. Diagnosis and treatment of phosphatase- 0r kinase-related disorders
WO2001075067A2 (en) * 2000-03-31 2001-10-11 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2001096546A2 (en) * 2000-06-16 2001-12-20 Incyte Genomics, Inc. Protein phosphatases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998049317A2 (en) * 1997-04-28 1998-11-05 Sugen, Inc. Diagnosis and treatment of phosphatase- 0r kinase-related disorders
WO2001075067A2 (en) * 2000-03-31 2001-10-11 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2001096546A2 (en) * 2000-06-16 2001-12-20 Incyte Genomics, Inc. Protein phosphatases

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 20 May 1999 (1999-05-20), "Homo sapiens mRNA, cDNA DKFZp566K0524, note: strong similarity to protein-tyrosine-phosphatase", XP002210402, Database accession no. AL050040 *
DATABASE GENESEQ 13 February 2002 (2002-02-13), "DNA encoding novel human diagnostic protein #6033; SEQ ID NO: 6033", XP002210412, Database accession no. AAS70229 *
DATABASE GENESEQ 13 February 2002 (2002-02-13), "Novel human diagnostic protein #6033; SEQ ID NO: 36401", XP002210411, Database accession no. ABG06042 *
OHSUGI MIHO ET AL: "Molecular cloning and characterization of a novel cytoplasmic protein-tyrosine phosphatase that is specifically expressed in spermatocytes.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 52, 26 December 1997 (1997-12-26), pages 33092 - 33099, XP002210400, ISSN: 0021-9258 *
OSTMAN ARNE ET AL: "Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases.", TRENDS IN CELL BIOLOGY, vol. 11, no. 6, June 2001 (2001-06-01), pages 258 - 266, XP002210401, ISSN: 0962-8924 *
ZHANG Z-Y: "PROTEIN TYROSINE PHOSPHATASES: PROSPECTS FOR THERAPEUTICS", CURRENT OPINION IN CHEMICAL BIOLOGY, CURRENT BIOLOGY LTD, LONDON, GB, vol. 5, no. 4, 1 August 2001 (2001-08-01), pages 416 - 423, XP001039802, ISSN: 1367-5931 *

Also Published As

Publication number Publication date
WO2002042435A2 (en) 2002-05-30
AU2002233201A1 (en) 2002-06-03

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