WO2002038126A3 - Procede de production de particules pour preparations pharmaceutiques presentant une biodisponibilite accrue - Google Patents

Procede de production de particules pour preparations pharmaceutiques presentant une biodisponibilite accrue Download PDF

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Publication number
WO2002038126A3
WO2002038126A3 PCT/DK2001/000715 DK0100715W WO0238126A3 WO 2002038126 A3 WO2002038126 A3 WO 2002038126A3 DK 0100715 W DK0100715 W DK 0100715W WO 0238126 A3 WO0238126 A3 WO 0238126A3
Authority
WO
WIPO (PCT)
Prior art keywords
particles
production
increased bioavailability
pharmaceutical compositions
hpmcas
Prior art date
Application number
PCT/DK2001/000715
Other languages
English (en)
Other versions
WO2002038126A2 (fr
Inventor
Ove Emil Hansen
Original Assignee
Ove Emil Hansen
Aeromatic Fielder Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ove Emil Hansen, Aeromatic Fielder Ag filed Critical Ove Emil Hansen
Priority to AU2002212102A priority Critical patent/AU2002212102A1/en
Publication of WO2002038126A2 publication Critical patent/WO2002038126A2/fr
Publication of WO2002038126A3 publication Critical patent/WO2002038126A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé de production de particules pour une préparation pharmaceutique présentant une biodisponibilité accrue. Ce procédé comprend la vaporisation d'un noyau doté d'une solution ou d'une dispersion comprenant du succinate acétate hydroxypropylméthylcellulose (HPMCAS) et un composant actif pharmaceutique modérément soluble dans l'eau dans un liquide évaporable, l'évaporation du liquide afin d'obtenir un dépôt de HPMCAS et des composants actifs pharmaceutiques modérément solubles dans l'eau soluble, puis répétition du procédé jusqu'à l'obtention d'une taille ou d'un poids de particule prédéterminé.
PCT/DK2001/000715 2000-11-08 2001-10-29 Procede de production de particules pour preparations pharmaceutiques presentant une biodisponibilite accrue WO2002038126A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002212102A AU2002212102A1 (en) 2000-11-08 2001-10-29 A process for production of particles for pharmaceutical compositions having increased bioavailability

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70796600A 2000-11-08 2000-11-08
US09/707,966 2000-11-08

Publications (2)

Publication Number Publication Date
WO2002038126A2 WO2002038126A2 (fr) 2002-05-16
WO2002038126A3 true WO2002038126A3 (fr) 2002-10-10

Family

ID=24843867

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2001/000715 WO2002038126A2 (fr) 2000-11-08 2001-10-29 Procede de production de particules pour preparations pharmaceutiques presentant une biodisponibilite accrue

Country Status (2)

Country Link
AU (1) AU2002212102A1 (fr)
WO (1) WO2002038126A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103153343B (zh) * 2010-06-14 2015-02-11 陶氏环球技术有限责任公司 具有提高的醋酸酯和琥珀酸酯取代的醋酸羟丙基甲基纤维素琥珀酸酯
US9084727B2 (en) 2011-05-10 2015-07-21 Bend Research, Inc. Methods and compositions for maintaining active agents in intra-articular spaces

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
US8207232B2 (en) * 2004-05-28 2012-06-26 Bend Research, Inc. Pharmaceutical compositions with enhanced performance
CA2810655C (fr) 2004-06-24 2013-12-10 Vertex Pharmaceuticals Incorporated Modulateurs de transporteurs de cassette de liaison a l'atp
EP3708564A1 (fr) 2005-12-28 2020-09-16 Vertex Pharmaceuticals Incorporated Une forme solide de n-[2,4-bis(1,1-diméthyléthyl)-5-hydroxyphényl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
KR101852173B1 (ko) 2009-03-20 2018-04-27 버텍스 파마슈티칼스 인코포레이티드 낭성 섬유증 막횡단 전도도 조절자의 조정자의 제조 방법
CN104470518A (zh) 2012-02-27 2015-03-25 沃泰克斯药物股份有限公司 药物组合物及其施用
JP6746569B2 (ja) 2014-10-07 2020-08-26 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 嚢胞性線維症膜貫通コンダクタンス制御因子のモジュレーターの共結晶

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0344603A1 (fr) * 1988-05-30 1989-12-06 Zeria Pharmaceutical Co., Ltd. Composition pharmaceutique contenant un dérivé de la dihydropyridine
WO1993000991A1 (fr) * 1991-07-03 1993-01-21 Smithkline Beecham Plc Procede de preparation de substances medicamenteuses sous forme de granules
WO1995020432A1 (fr) * 1994-01-27 1995-08-03 Aeromatic-Fielder Ag Dispositif d'enrobage de particules solides
EP0901786A2 (fr) * 1997-08-11 1999-03-17 Pfizer Products Inc. Dispersions solides pharmaceutiques à biodisponibilité accrue
US5985322A (en) * 1997-05-29 1999-11-16 Eli Lilly And Company Method for the treatment of CNS disorders
WO2000040339A1 (fr) * 1998-12-30 2000-07-13 Aeromatic-Fielder Ag Appareil et procede d'enrobage de comprimes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0344603A1 (fr) * 1988-05-30 1989-12-06 Zeria Pharmaceutical Co., Ltd. Composition pharmaceutique contenant un dérivé de la dihydropyridine
WO1993000991A1 (fr) * 1991-07-03 1993-01-21 Smithkline Beecham Plc Procede de preparation de substances medicamenteuses sous forme de granules
WO1995020432A1 (fr) * 1994-01-27 1995-08-03 Aeromatic-Fielder Ag Dispositif d'enrobage de particules solides
US5985322A (en) * 1997-05-29 1999-11-16 Eli Lilly And Company Method for the treatment of CNS disorders
EP0901786A2 (fr) * 1997-08-11 1999-03-17 Pfizer Products Inc. Dispersions solides pharmaceutiques à biodisponibilité accrue
WO2000040339A1 (fr) * 1998-12-30 2000-07-13 Aeromatic-Fielder Ag Appareil et procede d'enrobage de comprimes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103153343B (zh) * 2010-06-14 2015-02-11 陶氏环球技术有限责任公司 具有提高的醋酸酯和琥珀酸酯取代的醋酸羟丙基甲基纤维素琥珀酸酯
US9084727B2 (en) 2011-05-10 2015-07-21 Bend Research, Inc. Methods and compositions for maintaining active agents in intra-articular spaces

Also Published As

Publication number Publication date
AU2002212102A1 (en) 2002-05-21
WO2002038126A2 (fr) 2002-05-16

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