AU2001262011A1 - A complex between folic acid and polysaccharides, its preparation method and a pharmaceutical composition comprising said complex as active component - Google Patents

A complex between folic acid and polysaccharides, its preparation method and a pharmaceutical composition comprising said complex as active component

Info

Publication number
AU2001262011A1
AU2001262011A1 AU2001262011A AU6201101A AU2001262011A1 AU 2001262011 A1 AU2001262011 A1 AU 2001262011A1 AU 2001262011 A AU2001262011 A AU 2001262011A AU 6201101 A AU6201101 A AU 6201101A AU 2001262011 A1 AU2001262011 A1 AU 2001262011A1
Authority
AU
Australia
Prior art keywords
complex
polysaccharides
preparation
pharmaceutical composition
active component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001262011A
Inventor
Min Liu
Weiyue Lu
Jun Pan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fudan University
Shanghai Pharmco Research Inc
Original Assignee
Fudan University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fudan University filed Critical Fudan University
Publication of AU2001262011A1 publication Critical patent/AU2001262011A1/en
Assigned to FUDAN UNIVERSITY, SHANGHAI PHARMCO RESEARCH, INC. reassignment FUDAN UNIVERSITY Request for Assignment Assignors: FUDAN UNIVERSITY
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
AU2001262011A 2000-04-17 2001-04-16 A complex between folic acid and polysaccharides, its preparation method and a pharmaceutical composition comprising said complex as active component Abandoned AU2001262011A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN00115400 2000-04-17
CN00115400 2000-04-17
CN00115752 2000-05-18
CN00115752A CN1095472C (en) 2000-04-17 2000-05-18 Folica acid-polysaccharide composite and its preparation and medical composition with the composite as active component
PCT/CN2001/000555 WO2001079302A1 (en) 2000-04-17 2001-04-16 A complex between folic acid and polysaccharides, its preparation method and a pharmaceutical composition comprising said complex as active component

Publications (1)

Publication Number Publication Date
AU2001262011A1 true AU2001262011A1 (en) 2001-10-30

Family

ID=25739437

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001262011A Abandoned AU2001262011A1 (en) 2000-04-17 2001-04-16 A complex between folic acid and polysaccharides, its preparation method and a pharmaceutical composition comprising said complex as active component

Country Status (7)

Country Link
US (1) US7005426B2 (en)
EP (1) EP1291362A4 (en)
JP (1) JP2003533555A (en)
CN (1) CN1095472C (en)
AU (1) AU2001262011A1 (en)
CA (1) CA2407065A1 (en)
WO (1) WO2001079302A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008515915A (en) * 2004-10-07 2008-05-15 エモリー ユニバーシティー Multifunctional nanoparticle conjugates and their use
US20070042970A1 (en) * 2005-08-22 2007-02-22 Chemical Soft R&D Inc. Folate-modified cholesterol-bearing pullulan as a drug carrier
US8394391B2 (en) * 2007-08-31 2013-03-12 University Of Utah Research Foundation Drug delivery vehicle that mimics viral properties
CN101235102B (en) * 2008-02-18 2010-11-03 南昌航空大学 Method for preparing folic acid coupling hydroxypropyl chitosan nano particles
CN104116755A (en) * 2014-06-19 2014-10-29 无限极（中国）有限公司 Ganoderma lucidum, wolfberry and rhizoma polygonati compound polysaccharide with tumor microenvironment regulation function as well as preparation method and application thereof
CN104491873A (en) * 2014-12-10 2015-04-08 江南大学 Preparation method of heparin-folic acid conjugate with low anticoagulant activity and tumor targeting property
BR112019002495A2 (en) 2016-08-12 2019-05-14 L.E.A.F. Holdings Group Llc polyglutamate antifolates and their uses
WO2019157129A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated pralatrexate and uses thereof
CA3090494A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated pemetrexed and uses thereof
US20210346381A1 (en) * 2018-02-07 2021-11-11 L.E.A.F. Holdings Group Llc Alpha polyglutamated tetrahydrofolates and uses thereof
CA3090992A1 (en) * 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated tetrahydrofolates and uses thereof
EP3752157A4 (en) 2018-02-14 2022-07-06 L.E.A.F Holdings Group LLC Gamma polyglutamated lometrexol and uses thereof
CN109456330B (en) * 2018-11-26 2021-05-14 连云港德洋化工有限公司 Folic acid stable compound and its preparing method
CN110357981B (en) * 2019-07-22 2023-08-04 福建亿彤生物科技有限公司 Polysaccharide carrier with endocytosis mediated function and preparation method thereof
KR102619293B1 (en) * 2021-01-14 2023-12-29 주식회사 엔바이오스 Anti cancer composition comprising SP-FA conjugates as active ingredient
CN113087813B (en) * 2021-03-17 2021-11-02 广州芊亮科技有限公司 Tea bran extraction process

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1767499A1 (en) * 1968-05-16 1971-09-09 Merck Patent Gmbh Process for the production of durable vitamin preparations
GB1541435A (en) * 1975-02-04 1979-02-28 Searle & Co Immunological materials
JPS59152327A (en) * 1983-02-16 1984-08-31 Otsuka Pharmaceut Co Ltd Stabilized vitamin preparation
JPS61207237A (en) * 1985-03-11 1986-09-13 Nippon Soken Inc Rotary car seat
US5554386A (en) * 1986-07-03 1996-09-10 Advanced Magnetics, Inc. Delivery of therapeutic agents to receptors using polysaccharides
US4857505A (en) * 1987-03-09 1989-08-15 American Cyanamid Company Sustained release compositions for parenteral administration and their use
DE3744068A1 (en) * 1987-12-24 1989-07-06 Boehringer Mannheim Gmbh METHOD FOR THE PRODUCTION OF A HAPTENIZED POLYSACCHARIDE MATRIX
DE3904119A1 (en) * 1989-02-11 1990-08-16 Hoechst Ag POLYMER FIXED METHOTREXATE, METHOD FOR PRODUCTION AND USE
US5108921A (en) * 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
DE563249T1 (en) * 1990-12-19 1994-03-03 Advanced Magnetics Inc TARGETING THERAPEUTIC AGENTS BY USING POLYSACCHARIDES.
CH684644A5 (en) * 1992-07-13 1994-11-15 Eprova Ag 5,10-methylenetetrahydrofolic acid-cyclodextrin inclusion compounds.
US5547668A (en) * 1995-05-05 1996-08-20 The Board Of Trustees Of The University Of Illinois Conjugates of folate anti-effector cell antibodies

Also Published As

Publication number Publication date
EP1291362A4 (en) 2005-02-02
CN1095472C (en) 2002-12-04
EP1291362A1 (en) 2003-03-12
US7005426B2 (en) 2006-02-28
WO2001079302A1 (en) 2001-10-25
CN1287127A (en) 2001-03-14
US20030125302A1 (en) 2003-07-03
CA2407065A1 (en) 2001-10-25
JP2003533555A (en) 2003-11-11

Similar Documents

Publication Publication Date Title
AU2001237526A1 (en) Pharmaceutical compositions containing 3-amino-azetidine derivatives, novel derivatives and preparation thereof
AU2001262318A1 (en) Acylphenyl urea derivatives, methods for the production thereof and use thereof as a medicament
AU2001262011A1 (en) A complex between folic acid and polysaccharides, its preparation method and a pharmaceutical composition comprising said complex as active component
AU2001237525A1 (en) Azetidine derivatives, preparation thereof and pharmaceutical compositions containing same
ZA200301813B (en) Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them.
AU2002213977A1 (en) Novel anticholinergics, method for the production thereof and use thereof as medicaments
AU2002342968A1 (en) Fatty acid compounds, preparation and uses thereof
AU2001278771A1 (en) Carboxylic acid derivatives, process for producing the same and drugs containingthe same as the active ingredient
AU2002352334A1 (en) Pharmaceutical composition based on micronized progesterone, preparation method and uses thereof
AU2682401A (en) Flavonoid drug and dosage form, its production and use
AU2002233463A1 (en) Urea derivatives, method for preparing same, use thereof as medicines, pharmaceutical compositions and use
AU2001277602A1 (en) Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same
ZA200109602B (en) Purine derivatives, preparation method and pharmaceutical compositions containing same.
AU2001234107A1 (en) Benzoic acid derivatives, process for producing the same and drugs containing the same as the active ingredient
AU2001263835A1 (en) Haemostatically active preparation containing vWF and method for the production thereof
AU3560601A (en) Novel isoquinoline derivatives, preparation method and pharmaceutical compositions containing them
AU2001269252A1 (en) Alcohol-free base for aqueous perfume composition, and alcohol-free aqueous perfume composition comprising same
AU2003224482A1 (en) Quinoline derivatives as caspase-3 inhibitor, preparation for producing the same and pharmaceutical composition comprising the same
AU2000254308A1 (en) Pyrazolopyrimidinone derivatives, process for their preparation and their use
AU2001254812A1 (en) 9-oxa-epothilon derivatives, method for the production and use thereof in pharmaceutical preparations
AU4884701A (en) Malonanilic acid derivatives, medicinal compositions containing the same and usethereof
AU2001293697A1 (en) N-substituted-1-amino-1,1-dialkylcarboxylic acid derivatives
AU2002222026A1 (en) Novel pharmaceutical compositions with anti-diabetic activity and method for preparing same
AU2001250625A1 (en) 19-norbufalin derivatives, their preparation and pharmaceutical compositions containing them
AU2001241067A1 (en) Omega-substituted phenyl-prostaglandin e-alcohols, process for producing the same and drugs containing the same as the active ingredient