WO2002036546A3 - Alkynyl amides and their therapeutic applications - Google Patents

Alkynyl amides and their therapeutic applications Download PDF

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Publication number
WO2002036546A3
WO2002036546A3 PCT/US2001/045704 US0145704W WO0236546A3 WO 2002036546 A3 WO2002036546 A3 WO 2002036546A3 US 0145704 W US0145704 W US 0145704W WO 0236546 A3 WO0236546 A3 WO 0236546A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic applications
alkynyl amides
alkynyl
amides
migraine
Prior art date
Application number
PCT/US2001/045704
Other languages
French (fr)
Other versions
WO2002036546A2 (en
Inventor
Youssef L Bennani
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to EP01989847A priority Critical patent/EP1330429A2/en
Priority to MXPA03003926A priority patent/MXPA03003926A/en
Priority to AU2002228726A priority patent/AU2002228726A1/en
Priority to CA2427560A priority patent/CA2427560C/en
Priority to JP2002539306A priority patent/JP4115835B2/en
Publication of WO2002036546A2 publication Critical patent/WO2002036546A2/en
Publication of WO2002036546A3 publication Critical patent/WO2002036546A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compounds of formula (I), are novel and useful for treating seizure, migraine and psychiatric disorders.
PCT/US2001/045704 2000-11-01 2001-10-31 Alkynyl amides and their therapeutic applications WO2002036546A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP01989847A EP1330429A2 (en) 2000-11-01 2001-10-31 Alkynyl amides and their therapeutic applications
MXPA03003926A MXPA03003926A (en) 2000-11-01 2001-10-31 Alkynyl amides and their therapeutic applications.
AU2002228726A AU2002228726A1 (en) 2000-11-01 2001-10-31 Alkynyl amides and their therapeutic applications
CA2427560A CA2427560C (en) 2000-11-01 2001-10-31 Alkynyl amides and their therapeutic applications
JP2002539306A JP4115835B2 (en) 2000-11-01 2001-10-31 Alkynilamide and its therapeutic application

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70377100A 2000-11-01 2000-11-01
US09/703,771 2000-11-01

Publications (2)

Publication Number Publication Date
WO2002036546A2 WO2002036546A2 (en) 2002-05-10
WO2002036546A3 true WO2002036546A3 (en) 2002-10-10

Family

ID=24826711

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/045704 WO2002036546A2 (en) 2000-11-01 2001-10-31 Alkynyl amides and their therapeutic applications

Country Status (8)

Country Link
EP (1) EP1330429A2 (en)
JP (1) JP4115835B2 (en)
AU (1) AU2002228726A1 (en)
CA (1) CA2427560C (en)
MX (1) MXPA03003926A (en)
PE (1) PE20020575A1 (en)
UY (1) UY26997A1 (en)
WO (1) WO2002036546A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050101655A1 (en) * 2003-11-12 2005-05-12 Artman Linda D. Migraine treatments including isovaleramide compounds and serotonin agonists
DE102005062987A1 (en) * 2005-12-28 2007-07-05 Grünenthal GmbH New substituted propiolic acid amides, useful for treatment and prevention of e.g. pain, anxiety and panic attacks, are inhibitors of the mGluR5 receptor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995001956A1 (en) * 1993-07-06 1995-01-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem Derivatives of valproic and 2-valproenoic acid amides and use as anticonvulsants

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995001956A1 (en) * 1993-07-06 1995-01-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem Derivatives of valproic and 2-valproenoic acid amides and use as anticonvulsants

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARM. KHIM. ZH., vol. 26, no. 10, - 1973, pages 837 - 842 *
CHEMICAL ABSTRACTS, vol. 80, no. 15, 15 April 1974, Columbus, Ohio, US; abstract no. 81951n, R. S. GYULI-KEVKHYAN ET AL.: "Substituted 6-(dialkylamino)-2-hexynes" page 319; column 2; XP002204964 *
ELMAZAR M M A ET AL: "ANTICONVULSANT AND NEUROTOXIC ACTIVITIES OF TWELVE ANALOGUES OF VALPROIC ACID", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 82, no. 12, 1 December 1993 (1993-12-01), pages 1255 - 1258, XP002026656, ISSN: 0022-3549 *
PETER A. JACOBI ET AL.: "Studies on Corrin Synthesis. A Solution to the Introduction of Meso Substituents", JOURNAL OF ORGANIC CHEMISTRY, vol. 64, no. 6, 1999, EASTON US, pages 1778 - 1779, XP002204963 *

Also Published As

Publication number Publication date
CA2427560C (en) 2010-12-07
AU2002228726A1 (en) 2002-05-15
JP2004532804A (en) 2004-10-28
MXPA03003926A (en) 2004-05-24
JP4115835B2 (en) 2008-07-09
PE20020575A1 (en) 2002-06-25
EP1330429A2 (en) 2003-07-30
UY26997A1 (en) 2002-07-31
CA2427560A1 (en) 2002-05-10
WO2002036546A2 (en) 2002-05-10

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