BR0017157A - 6-hydroxy-indazole derivatives for the treatment of glaucoma - Google Patents

6-hydroxy-indazole derivatives for the treatment of glaucoma

Info

Publication number
BR0017157A
BR0017157A BR0017157-3A BR0017157A BR0017157A BR 0017157 A BR0017157 A BR 0017157A BR 0017157 A BR0017157 A BR 0017157A BR 0017157 A BR0017157 A BR 0017157A
Authority
BR
Brazil
Prior art keywords
glaucoma
hydroxy
treatment
indazole derivatives
derivatives
Prior art date
Application number
BR0017157-3A
Other languages
Portuguese (pt)
Inventor
Jesse A May
Anura P Dantanarayana
Zixia Feng
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of BR0017157A publication Critical patent/BR0017157A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"DERIVADOS DE 6-HIDRóXI-INDAZOL PARA O TRATAMENTO DE GLAUCOMA". São divulgados 1-(<244>-alquil-etilamino)-1H-indazol-6-óis substituídos, úteis para diminuir e controlar a IOP e tratar o glaucoma."6-HYDROXY-INDAZOL DERIVATIVES FOR THE TREATMENT OF GLAUCOMA". Substituted 1- (<244> -alkyl-ethylamino) -1H-indazol-6-ools are disclosed, useful for decreasing and controlling IOP and treating glaucoma.

BR0017157-3A 2000-03-17 2000-11-14 6-hydroxy-indazole derivatives for the treatment of glaucoma BR0017157A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19038000P 2000-03-17 2000-03-17
PCT/US2000/031247 WO2001070702A1 (en) 2000-03-17 2000-11-14 6-hydroxy-indazole derivatives for treating glaucoma

Publications (1)

Publication Number Publication Date
BR0017157A true BR0017157A (en) 2002-11-26

Family

ID=22701093

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0017157-3A BR0017157A (en) 2000-03-17 2000-11-14 6-hydroxy-indazole derivatives for the treatment of glaucoma

Country Status (14)

Country Link
EP (1) EP1268438A1 (en)
JP (1) JP2003528085A (en)
KR (1) KR20030065304A (en)
CN (1) CN1450994A (en)
AR (1) AR032138A1 (en)
AU (1) AU2001216072A1 (en)
BR (1) BR0017157A (en)
CA (1) CA2402403A1 (en)
GC (1) GC0000155A (en)
MX (1) MXPA02008547A (en)
PL (1) PL358481A1 (en)
TW (1) TWI221839B (en)
WO (1) WO2001070702A1 (en)
ZA (1) ZA200206851B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
WO2003057213A2 (en) * 2001-12-28 2003-07-17 Bayer Pharmaceuticals Corporation Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor
CN100384827C (en) * 2002-11-08 2008-04-30 默克公司 Ophthalmic compositions for treating ocular hypertension
JP2006510742A (en) 2002-11-08 2006-03-30 メルク　エンド　カムパニー　インコーポレーテッド Ophthalmic composition for high intraocular pressure treatment
US7196082B2 (en) 2002-11-08 2007-03-27 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
US7053085B2 (en) 2003-03-26 2006-05-30 Merck & Co. Inc. EP4 receptor agonist, compositions and methods thereof
CA2506204A1 (en) 2002-12-13 2004-07-01 Alcon, Inc. Novel benzopyran analogs and their use for the treatment of glaucoma
JP2004262812A (en) * 2003-02-28 2004-09-24 Rohto Pharmaceut Co Ltd Hypotonia bulbi medicine
JP2007504228A (en) 2003-09-02 2007-03-01 メルク　エンド　カムパニー　インコーポレーテッド Ophthalmic composition for treating ocular hypertension
WO2005026128A1 (en) 2003-09-04 2005-03-24 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
EP1663221A4 (en) 2003-09-04 2009-04-22 Merck & Co Inc Ophthalmic compositions for treating ocular hypertension
WO2005058911A2 (en) 2003-12-15 2005-06-30 Alcon, Inc. Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
JP2008507521A (en) 2004-07-20 2008-03-13 メルク　エンド　カムパニー　インコーポレーテッド Ophthalmic composition for treating ocular hypertension
BRPI0518693A2 (en) 2004-11-29 2008-12-02 Warner Lambert Co pyrazol [3,4-b] pyridines and therapeutic indoles as well as pharmaceutical composition and use thereof
US7425572B2 (en) 2004-12-08 2008-09-16 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
CN101704785B (en) * 2009-11-16 2012-02-29 东南大学 Organic dicarboxylic acid and salts thereof and preparation method thereof
CN105884687B (en) * 2016-04-14 2018-06-22 梯尔希（南京）药物研发有限公司 A kind of preparation method of 5- benzyls benzydamine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002515408A (en) * 1998-05-19 2002-05-28 アルコン ラボラトリーズ， インコーポレーテッド Serotonergic 5HT7 receptor compounds for the treatment of ocular and central nervous system disorders
EP0985414B1 (en) * 1998-05-26 2003-08-27 Pfizer Products Inc. Medicament for the treatment of glaucoma and ischemic retinopathy
GB9819032D0 (en) * 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds IV
JP2002526443A (en) * 1998-09-18 2002-08-20 アルコン ラボラトリーズ， インコーポレーテッド Serotoninergic 5HT2 agonist for treating glaucoma
GB9820767D0 (en) * 1998-09-23 1998-11-18 Cerebrus Ltd Chemical compounds VIII

Also Published As

Publication number Publication date
MXPA02008547A (en) 2003-03-12
KR20030065304A (en) 2003-08-06
PL358481A1 (en) 2004-08-09
EP1268438A1 (en) 2003-01-02
CN1450994A (en) 2003-10-22
ZA200206851B (en) 2003-10-21
CA2402403A1 (en) 2001-09-27
GC0000155A (en) 2005-06-29
WO2001070702A1 (en) 2001-09-27
JP2003528085A (en) 2003-09-24
AU2001216072A1 (en) 2001-10-03
TWI221839B (en) 2004-10-11
AR032138A1 (en) 2003-10-29

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1962 DE 12/08/2008.