WO2002032919A3 - 6-o-substituted erythromycin derivatives having improved gastrointestinal tolerance - Google Patents

6-o-substituted erythromycin derivatives having improved gastrointestinal tolerance Download PDF

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Publication number
WO2002032919A3
WO2002032919A3 PCT/US2001/032278 US0132278W WO0232919A3 WO 2002032919 A3 WO2002032919 A3 WO 2002032919A3 US 0132278 W US0132278 W US 0132278W WO 0232919 A3 WO0232919 A3 WO 0232919A3
Authority
WO
WIPO (PCT)
Prior art keywords
erythromycin derivatives
gastrointestinal tolerance
improved gastrointestinal
substituted erythromycin
compounds
Prior art date
Application number
PCT/US2001/032278
Other languages
French (fr)
Other versions
WO2002032919A2 (en
Inventor
Zhenkun Ma
Ly Tam Pham
Richard F Clark
Souming Zhang
Stevan Djuric
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to JP2002536300A priority Critical patent/JP2004529857A/en
Priority to EP01981637A priority patent/EP1328534A2/en
Priority to MXPA03003311A priority patent/MXPA03003311A/en
Priority to BR0109946-9A priority patent/BR0109946A/en
Priority to CA002420012A priority patent/CA2420012A1/en
Priority to AU2002213267A priority patent/AU2002213267A1/en
Publication of WO2002032919A2 publication Critical patent/WO2002032919A2/en
Publication of WO2002032919A3 publication Critical patent/WO2002032919A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Compounds having formula (I) are useful for treating bacterial infections while avoiding the concomitant liability of gastrointestinal intolerance. Compositions containing the compounds and methods of treatment using the compounds are also disclosed.
PCT/US2001/032278 2000-10-16 2001-10-16 6-o-substituted erythromycin derivatives having improved gastrointestinal tolerance WO2002032919A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2002536300A JP2004529857A (en) 2000-10-16 2001-10-16 6-O-substituted erythromycin derivatives having improved gastrointestinal resistance
EP01981637A EP1328534A2 (en) 2000-10-16 2001-10-16 6-o-substituted erythromycin derivatives having improved gastrointestinal tolerance
MXPA03003311A MXPA03003311A (en) 2000-10-16 2001-10-16 6-o-substituted erythromycin derivatives having improved gastrointestinal tolerance.
BR0109946-9A BR0109946A (en) 2000-10-16 2001-10-16 6-O-Substituted Erythromycin Derivatives Having Gastrointestinal Tolerance
CA002420012A CA2420012A1 (en) 2000-10-16 2001-10-16 6-o-substituted erythromycin derivatives having improved gastrointestinal tolerance
AU2002213267A AU2002213267A1 (en) 2000-10-16 2001-10-16 6-o-substituted erythromycin derivatives having improved gastrointestinal tolerance

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24077700P 2000-10-16 2000-10-16
US60/240,777 2000-10-16

Publications (2)

Publication Number Publication Date
WO2002032919A2 WO2002032919A2 (en) 2002-04-25
WO2002032919A3 true WO2002032919A3 (en) 2002-09-19

Family

ID=22907903

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/032278 WO2002032919A2 (en) 2000-10-16 2001-10-16 6-o-substituted erythromycin derivatives having improved gastrointestinal tolerance

Country Status (9)

Country Link
EP (1) EP1328534A2 (en)
JP (1) JP2004529857A (en)
AU (1) AU2002213267A1 (en)
BR (1) BR0109946A (en)
CA (1) CA2420012A1 (en)
MX (1) MXPA03003311A (en)
PE (1) PE20020522A1 (en)
UY (1) UY26964A1 (en)
WO (1) WO2002032919A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0214748A (en) 2001-12-05 2004-11-23 Ortho Mcneil Pharm Inc Erythromycin 6-oacyl ketolide derivatives useful as antibacterials
EP1501845A1 (en) * 2002-04-30 2005-02-02 Abbott Laboratories Antibacterial compounds with improved pharmacokinetic profiles
US6727229B2 (en) * 2002-08-19 2004-04-27 Enanta Pharmaceuticals, Inc. 11,12-substituted lactone ketolide derivatives having antibacterial activity
WO2004078771A1 (en) * 2003-03-07 2004-09-16 Taisho Pharmaceutical Co., Ltd. 2-fluoro-6-o-substituted ketolide derivative
JP2007223900A (en) * 2004-02-03 2007-09-06 Taisho Pharmaceut Co Ltd 6-o-substituted ketolide derivative
JP2007254285A (en) * 2004-03-16 2007-10-04 Taisho Pharmaceut Co Ltd 2-fluoro-6-o-substituted ketolide derivative
EP1985620A4 (en) 2006-02-07 2012-08-15 Taisho Pharmaceutical Co Ltd 10a-AZALIDE COMPOUND
EP2177526A4 (en) 2007-08-06 2012-08-22 Taisho Pharmaceutical Co Ltd 10a-azalide compound crosslinked at position-10a and position-12
EP2287173A4 (en) 2008-05-15 2013-06-19 Taisho Pharmaceutical Co Ltd 10a-azalide compound having 4-membered ring structure
CN102234302B (en) * 2010-05-07 2014-05-07 北京理工大学 Novel ketolide derivatives, and preparation method and medicinal compositions thereof
AR085286A1 (en) 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd MACROLIDO DERIVATIVE REPLACED IN POSITION C-4
AR102810A1 (en) 2014-08-18 2017-03-29 Taisho Pharmaceutical Co Ltd MACROLID DERIVATIVE REPLACED IN POSITION C-4

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity

Also Published As

Publication number Publication date
WO2002032919A2 (en) 2002-04-25
PE20020522A1 (en) 2002-06-25
EP1328534A2 (en) 2003-07-23
JP2004529857A (en) 2004-09-30
CA2420012A1 (en) 2002-04-25
MXPA03003311A (en) 2003-09-10
UY26964A1 (en) 2002-06-20
BR0109946A (en) 2005-08-02
AU2002213267A1 (en) 2002-04-29

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