WO2002029035A3 - Procede destine a modifier des fragments de sucre - Google Patents

Procede destine a modifier des fragments de sucre Download PDF

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Publication number
WO2002029035A3
WO2002029035A3 PCT/US2001/031255 US0131255W WO0229035A3 WO 2002029035 A3 WO2002029035 A3 WO 2002029035A3 US 0131255 W US0131255 W US 0131255W WO 0229035 A3 WO0229035 A3 WO 0229035A3
Authority
WO
WIPO (PCT)
Prior art keywords
sugar moieties
alter
alter sugar
moieties
sugars
Prior art date
Application number
PCT/US2001/031255
Other languages
English (en)
Other versions
WO2002029035A2 (fr
Inventor
Hung-Wen Liu
David H Sherman
Lishan Zhao
Original Assignee
Univ Minnesota
Hung-Wen Liu
David H Sherman
Lishan Zhao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minnesota, Hung-Wen Liu, David H Sherman, Lishan Zhao filed Critical Univ Minnesota
Priority to JP2002532605A priority Critical patent/JP2004534502A/ja
Priority to CA002424567A priority patent/CA2424567A1/fr
Priority to AU2001296652A priority patent/AU2001296652A1/en
Priority to US10/398,605 priority patent/US20040161839A1/en
Priority to EP01977540A priority patent/EP1325134A2/fr
Publication of WO2002029035A2 publication Critical patent/WO2002029035A2/fr
Publication of WO2002029035A3 publication Critical patent/WO2002029035A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/305—Pyrimidine nucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne un procédé destiné à modifier la structure de sucres.
PCT/US2001/031255 2000-10-05 2001-10-05 Procede destine a modifier des fragments de sucre WO2002029035A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2002532605A JP2004534502A (ja) 2000-10-05 2001-10-05 糖部分を変更するための方法
CA002424567A CA2424567A1 (fr) 2000-10-05 2001-10-05 Procede destine a modifier des fragments de sucre
AU2001296652A AU2001296652A1 (en) 2000-10-05 2001-10-05 Method to alter sugar moieties
US10/398,605 US20040161839A1 (en) 2001-10-05 2001-10-05 Method to alter sugar moieties
EP01977540A EP1325134A2 (fr) 2000-10-05 2001-10-05 Procede destine a modifier des fragments de sucre

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23818500P 2000-10-05 2000-10-05
US60/238,185 2000-10-05

Publications (2)

Publication Number Publication Date
WO2002029035A2 WO2002029035A2 (fr) 2002-04-11
WO2002029035A3 true WO2002029035A3 (fr) 2003-01-30

Family

ID=22896833

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/031255 WO2002029035A2 (fr) 2000-10-05 2001-10-05 Procede destine a modifier des fragments de sucre

Country Status (5)

Country Link
EP (1) EP1325134A2 (fr)
JP (1) JP2004534502A (fr)
AU (1) AU2001296652A1 (fr)
CA (1) CA2424567A1 (fr)
WO (1) WO2002029035A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109593740B (zh) * 2018-12-07 2021-01-29 广东省微生物研究所（广东省微生物分析检测中心） 一种糖基转移酶及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023630A2 (fr) * 1995-12-21 1997-07-03 Abbott Laboratories Genes de biosynthese de sucres associes a des polyketides
WO1999005283A2 (fr) * 1997-07-25 1999-02-04 Hoechst Marion Roussel Genes de biosynthese et de transfert des 6-desoxyhexoses chez saccharopolyspora erythraea et chez streptomyces antibioticus et leur utilisation
WO2000000620A2 (fr) * 1998-06-26 2000-01-06 Regents Of The University Of Minnesota Adn codant pour la methymycine et la pikromycine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023630A2 (fr) * 1995-12-21 1997-07-03 Abbott Laboratories Genes de biosynthese de sucres associes a des polyketides
WO1999005283A2 (fr) * 1997-07-25 1999-02-04 Hoechst Marion Roussel Genes de biosynthese et de transfert des 6-desoxyhexoses chez saccharopolyspora erythraea et chez streptomyces antibioticus et leur utilisation
WO2000000620A2 (fr) * 1998-06-26 2000-01-06 Regents Of The University Of Minnesota Adn codant pour la methymycine et la pikromycine

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
DOUMITH M ET AL.: "Interspecies complementation in Saccharopolyspora erythraea: Elucidation of the function of oleP1, oleG1 and oleG2 from the oleandomycin biosynthetic gene cluster of Streptomyces antibioticus and generation of new erythromycin derivatives.", MOLECULAR MICROBIOLOGY, vol. 34, no. 5, December 1999 (1999-12-01), pages 1039 - 1048, XP002210931, ISSN: 0950-382X *
GAISSER S ET AL.: "A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea.", MOLECULAR MICROBIOLOGY, vol. 36, no. 2, April 2000 (2000-04-01), pages 391 - 401, XP002210930, ISSN: 0950-382X *
GAISSER S ET AL.: "New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster.", MOLECULAR MICROBIOLOGY, vol. 41, no. 5, September 2001 (2001-09-01), pages 1223 - 1231, XP002210934, ISSN: 0950-382X *
GAISSER S ET AL.: "Sugaring the pill by design.", NATURE BIOTECHNOLOGY, vol. 16, no. 1, January 1998 (1998-01-01), pages 19 - 20, XP002210928, ISSN: 1087-0156 *
HUTCHINSON C R: "Combinatorial biosynthesis for new drug discovery", CURRENT OPINION IN MICROBIOLOGY, vol. 1, no. 3, 1998, pages 319 - 329, XP000993550, ISSN: 1369-5274 *
LIU H-W ET AL: "Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria", ANNUAL REVIEW OF MICROBIOLOGY, vol. 48, 1994, pages 223 - 256, XP002061259, ISSN: 0066-4227 *
MADDURI K ET AL.: "Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius.", NATURE BIOTECHNOLOGY, vol. 16, no. 1, January 1998 (1998-01-01), pages 69 - 74, XP002210929, ISSN: 1087-0156 *
See also references of EP1325134A2 *
XUE Y ET AL.: "A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: Architecture of metabolic diversity.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 95, no. 21, 13 October 1998 (1998-10-13), pages 12111 - 12116, XP002210932, ISSN: 0027-8424 *
YAMASE H ET AL.: "Engineering a Hybrid Sugar Biosynthetic Pathway: Production of L-Rhamnose and Its Implication on Dihydrostreptose Biosynthesis", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 122, no. 49, 13 December 2000 (2000-12-13), pages 12397 - 12398, XP002210933 *
ZHAO L ET AL.: "Engineering a methymycin/pikromycin-calicheamicin hybrid: Construction of two new macrolides carrying a designed sugar moiety", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 121, no. 42, 27 October 1999 (1999-10-27), pages 9881 - 9882, XP002210927 *

Also Published As

Publication number Publication date
JP2004534502A (ja) 2004-11-18
EP1325134A2 (fr) 2003-07-09
AU2001296652A1 (en) 2002-04-15
CA2424567A1 (fr) 2002-04-11
WO2002029035A2 (fr) 2002-04-11

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