WO2002024927A2 - Regulation de la proteine humaine de type precurseur de adam-ts1 - Google Patents

Regulation de la proteine humaine de type precurseur de adam-ts1 Download PDF

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Publication number
WO2002024927A2
WO2002024927A2 PCT/EP2001/010700 EP0110700W WO0224927A2 WO 2002024927 A2 WO2002024927 A2 WO 2002024927A2 EP 0110700 W EP0110700 W EP 0110700W WO 0224927 A2 WO0224927 A2 WO 0224927A2
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WIPO (PCT)
Prior art keywords
precursor
polypeptide
protein
adam
polynucleotide
Prior art date
Application number
PCT/EP2001/010700
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English (en)
Other versions
WO2002024927A3 (fr
Inventor
Jiing-Ren Liou
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Priority to AU2001289886A priority Critical patent/AU2001289886A1/en
Publication of WO2002024927A2 publication Critical patent/WO2002024927A2/fr
Publication of WO2002024927A3 publication Critical patent/WO2002024927A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention se rapporte à des réactifs qui régulent la protéine humaine de type précurseur de ADAM-TS1 et à des réactifs qui se lient au produit génique de la protéine humaine de type précurseur de ADAM-TS1. Ces réactifs peuvent jouer un rôle pour la prévention, l'amélioration ou la correction des dysfonctionnements ou des maladies incluant, entre autres, les troubles cardio-vasculaires et hépatiques et les broncho-pneumopathies chroniques obstructives.
PCT/EP2001/010700 2000-09-20 2001-09-17 Regulation de la proteine humaine de type precurseur de adam-ts1 WO2002024927A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001289886A AU2001289886A1 (en) 2000-09-20 2001-09-17 Regulation of human adam-ts 1 precursor-like protein

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US23420100P 2000-09-20 2000-09-20
US60/234,201 2000-09-20
US30715801P 2001-07-24 2001-07-24
US60/307,158 2001-07-24

Publications (2)

Publication Number Publication Date
WO2002024927A2 true WO2002024927A2 (fr) 2002-03-28
WO2002024927A3 WO2002024927A3 (fr) 2002-11-07

Family

ID=26927667

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/010700 WO2002024927A2 (fr) 2000-09-20 2001-09-17 Regulation de la proteine humaine de type precurseur de adam-ts1

Country Status (2)

Country Link
AU (1) AU2001289886A1 (fr)
WO (1) WO2002024927A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003042379A2 (fr) * 2001-11-13 2003-05-22 Universite De Liege Nouveau polynucleotide de desintegrine et metalloproteinase comportant une thrombospondine de type 1 et polypeptide code
US7125701B2 (en) 2001-07-27 2006-10-24 Wyeth Aggrecanase molecules
US7501118B2 (en) 1999-04-13 2009-03-10 Oscient Pharmaceuticals Corporation Human gene relating to respiratory diseases and obesity
CN111272746A (zh) * 2020-03-09 2020-06-12 中国水产科学研究院东海水产研究所 一种比色法测定水产品中游离氨基酸总量的方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000555A1 (fr) * 1996-07-03 1998-01-08 Prockop Darwin J N-proteinase de recombinaison, et production, procedes et utilisations de cette derniere
WO1999061656A2 (fr) * 1998-05-29 1999-12-02 Wisconsin Alumni Research Foundation Agent et methode pour moduler la migration cellulaire
WO2001059133A1 (fr) * 2000-02-14 2001-08-16 Merck Patent Gmbh Proteine larcap-1 associee au carcinome du larynx
WO2001083782A2 (fr) * 2000-05-04 2001-11-08 Sugen, Inc. Nouvelles proteases
WO2002016564A2 (fr) * 2000-08-22 2002-02-28 Lexicon Genetics Incorporated Nouvelles proteases humaines et polynucleotides codant lesdites proteases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000555A1 (fr) * 1996-07-03 1998-01-08 Prockop Darwin J N-proteinase de recombinaison, et production, procedes et utilisations de cette derniere
WO1999061656A2 (fr) * 1998-05-29 1999-12-02 Wisconsin Alumni Research Foundation Agent et methode pour moduler la migration cellulaire
WO2001059133A1 (fr) * 2000-02-14 2001-08-16 Merck Patent Gmbh Proteine larcap-1 associee au carcinome du larynx
WO2001083782A2 (fr) * 2000-05-04 2001-11-08 Sugen, Inc. Nouvelles proteases
WO2002016564A2 (fr) * 2000-08-22 2002-02-28 Lexicon Genetics Incorporated Nouvelles proteases humaines et polynucleotides codant lesdites proteases

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BOLZ^A^1 H ET AL: "Characterization of ADAMTS14, a novel member of the ADAMTS metalloproteinase family" BIOCHIMICA ET BIOPHYSICA ACTA. GENE STRUCTURE AND EXPRESSION, ELSEVIER, AMSTERDAM, NL, vol. 1522, no. 3, 30 December 2001 (2001-12-30), pages 221-225, XP004331262 ISSN: 0167-4781 *
DATABASE EMBL [Online] 22 August 2000 (2000-08-22) FROHME M.: "Homo sapiens EST, clone 3.3-n2" Database accession no. AJ403134 XP002201628 *
DATABASE EMBL [Online] 24 November 1998 (1998-11-24) COLIGE A.C.: "Homo sapiens mRNA for procollagen I-N proteinase" Database accession no. AJ003125 XP002201629 *
DATABASE EMBL [Online] 6 May 1999 (1999-05-06) BIRREN B. ET AL.: "Homo sapiens, clone RP11-91A1" Database accession no. AC007484 XP002201630 *
DIAS NETO EMMANUEL ET AL: "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 97, no. 7, 28 March 2000 (2000-03-28), pages 3491-3496, XP002201627 March 28, 2000 ISSN: 0027-8424 & DATABASE EMBL [Online] 16 January 2001 (2001-01-16) DIAS NETO E. ET AL: Database accession no. BF823025 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7501118B2 (en) 1999-04-13 2009-03-10 Oscient Pharmaceuticals Corporation Human gene relating to respiratory diseases and obesity
US7125701B2 (en) 2001-07-27 2006-10-24 Wyeth Aggrecanase molecules
WO2003042379A2 (fr) * 2001-11-13 2003-05-22 Universite De Liege Nouveau polynucleotide de desintegrine et metalloproteinase comportant une thrombospondine de type 1 et polypeptide code
WO2003042379A3 (fr) * 2001-11-13 2004-02-19 Univ Liege Nouveau polynucleotide de desintegrine et metalloproteinase comportant une thrombospondine de type 1 et polypeptide code
CN111272746A (zh) * 2020-03-09 2020-06-12 中国水产科学研究院东海水产研究所 一种比色法测定水产品中游离氨基酸总量的方法

Also Published As

Publication number Publication date
AU2001289886A1 (en) 2002-04-02
WO2002024927A3 (fr) 2002-11-07

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