WO2002020849A3 - Gene markers useful for detecting skin damage in response to ultraviolet radiation - Google Patents

Gene markers useful for detecting skin damage in response to ultraviolet radiation Download PDF

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Publication number
WO2002020849A3
WO2002020849A3 PCT/US2001/028214 US0128214W WO0220849A3 WO 2002020849 A3 WO2002020849 A3 WO 2002020849A3 US 0128214 W US0128214 W US 0128214W WO 0220849 A3 WO0220849 A3 WO 0220849A3
Authority
WO
WIPO (PCT)
Prior art keywords
ultraviolet radiation
response
radiation exposure
skin damage
gene markers
Prior art date
Application number
PCT/US2001/028214
Other languages
French (fr)
Other versions
WO2002020849A2 (en
Inventor
Miroslav Blumenberg
Original Assignee
Univ New York School Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York School Medicine filed Critical Univ New York School Medicine
Priority to JP2002525854A priority Critical patent/JP2004527218A/en
Priority to EP01970721A priority patent/EP1390528A2/en
Priority to AU2001290699A priority patent/AU2001290699A1/en
Priority to CA002423247A priority patent/CA2423247A1/en
Publication of WO2002020849A2 publication Critical patent/WO2002020849A2/en
Publication of WO2002020849A3 publication Critical patent/WO2002020849A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/148—Screening for cosmetic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Photometry And Measurement Of Optical Pulse Characteristics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The cellular response to ultraviolet radiation exposure has been characterized on the molecular level through the use of high density gene array technology. Nucleic acid molecules and protein molecules, the expression of which are repressed or induced in response to ultraviolet radiation exposure, are identified according to a temporal pattern of altered expression post ultraviolet radiation exposure. Methods are disclosed that utilized these ultraviolet radiation-regulated molecules as markers for ultraviolet radiation exposure. Other screening methods of the invention are designed for the identification of compounds that modulate the response of a cell to ultraviolet radiation exposure. The invention also provides compositions useful for drug screening or pharmaceuticals purposes.
PCT/US2001/028214 2000-09-08 2001-09-07 Gene markers useful for detecting skin damage in response to ultraviolet radiation WO2002020849A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2002525854A JP2004527218A (en) 2000-09-08 2001-09-07 Genetic markers useful for detecting UV-responsive skin damage
EP01970721A EP1390528A2 (en) 2000-09-08 2001-09-07 Gene markers useful for detecting skin damage in response to ultraviolet radiation
AU2001290699A AU2001290699A1 (en) 2000-09-08 2001-09-07 Gene markers useful for detecting skin damage in response to ultraviolet radiation
CA002423247A CA2423247A1 (en) 2000-09-08 2001-09-07 Gene markers useful for detecting skin damage in response to ultraviolet radiation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23106100P 2000-09-08 2000-09-08
US60/231,061 2000-09-08

Publications (2)

Publication Number Publication Date
WO2002020849A2 WO2002020849A2 (en) 2002-03-14
WO2002020849A3 true WO2002020849A3 (en) 2003-07-03

Family

ID=22867606

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/028214 WO2002020849A2 (en) 2000-09-08 2001-09-07 Gene markers useful for detecting skin damage in response to ultraviolet radiation

Country Status (5)

Country Link
EP (1) EP1390528A2 (en)
JP (1) JP2004527218A (en)
AU (1) AU2001290699A1 (en)
CA (1) CA2423247A1 (en)
WO (1) WO2002020849A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003027276A2 (en) * 2001-09-24 2003-04-03 University Of Aarhus Novel compositions and methods for diagnosis and treatment of lymphoma and leukemia
US20030232356A1 (en) * 2002-02-08 2003-12-18 Dooley Thomas P. Skin cell biomarkers and methods for identifying biomarkers using nucleic acid microarrays
JP5311439B2 (en) * 2006-12-27 2013-10-09 日本メナード化粧品株式会社 Method for evaluating skin condition and use thereof
US8741561B2 (en) 2010-03-01 2014-06-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Gene sets for detection of ultraviolet A exposure and methods of use thereof
JP6094481B2 (en) 2012-05-02 2017-03-15 三菱レイヨン株式会社 Probe or probe set and nucleic acid microarray for evaluating the influence of ultraviolet rays on the skin

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1085093A2 (en) * 1999-09-20 2001-03-21 New York University Genes and polynucleotides associated with ultraviolet radiation-mediated skin damage and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1085093A2 (en) * 1999-09-20 2001-03-21 New York University Genes and polynucleotides associated with ultraviolet radiation-mediated skin damage and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BLATTNER C ET AL: "UV-INDUCED STABILIZATION OF C-FOS AND OTHER SHORT-LIVED mRNA", MOLECULAR AND CELLULAR BIOLOGY, VOL. 20, NR. 10, PAGE(S) 3616-3625, ISSN: 0360-3016, XP001097227 *
HARRIS E E R ET AL: "USE OF MRNA DIFFERENTIAL DISPLAY TO IDENTIFY CHANGES IN GENE EXPRESSION IN HT29 HUMAN TUMOR CELLS AFTER EXPOSURE TO LOW DOSES OF IONIZING RADIATION", INTERNATIONAL JOURNAL OF RADIATION: ONCOLOGY BIOLOGY PHYSICS, PERGAMON PRESS, US, VOL. 30, NR. SUPPL 1, PAGE(S) 314, ISSN: 0360-3016, XP002035449 *

Also Published As

Publication number Publication date
CA2423247A1 (en) 2002-03-14
AU2001290699A1 (en) 2002-03-22
JP2004527218A (en) 2004-09-09
WO2002020849A2 (en) 2002-03-14
EP1390528A2 (en) 2004-02-25

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