WO2002020057A3 - Flavoring systems for pharmaceutical compositions and methods of making such compositions - Google Patents

Flavoring systems for pharmaceutical compositions and methods of making such compositions Download PDF

Info

Publication number
WO2002020057A3
WO2002020057A3 PCT/US2001/027415 US0127415W WO0220057A3 WO 2002020057 A3 WO2002020057 A3 WO 2002020057A3 US 0127415 W US0127415 W US 0127415W WO 0220057 A3 WO0220057 A3 WO 0220057A3
Authority
WO
WIPO (PCT)
Prior art keywords
mixtures
pharmaceutical compositions
flavored
flavoring
compositions
Prior art date
Application number
PCT/US2001/027415
Other languages
French (fr)
Other versions
WO2002020057A2 (en
Inventor
Laman Alani
Donald P Gauwitz
Dilip Kaul
John M Lipari
Soumojeet Ghosh
Kennan C Marsh
Richard H Whelan
Vanik D Petrossian
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to MXPA03001952A priority Critical patent/MXPA03001952A/en
Priority to EP01968449A priority patent/EP1315487A2/en
Priority to BRPI0108433-0A priority patent/BR0108433A/en
Priority to CA002417258A priority patent/CA2417258A1/en
Priority to JP2002524540A priority patent/JP2004522698A/en
Priority to AU2001288695A priority patent/AU2001288695A1/en
Publication of WO2002020057A2 publication Critical patent/WO2002020057A2/en
Publication of WO2002020057A3 publication Critical patent/WO2002020057A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)

Abstract

A flavoring system for a liquid pharmaceutical composition and pharmaceutical compositions containing such flavoring systems are disclosed. Flavoring systems of the invention include at least one sweetening agent, at least two flavored ingredients, and at least one flavor modifier selected from the group consisting of citric acid, sodium citrate, sodium chloride, and mixtures thereof. At least two of the flavored ingredients are selected from the group consisting of a vanilla flavored ingredient, a peppermint flavored ingredient, a menthol flavored ingredient, a cotton candy flavored ingredient, and mixtures thereof. The one or more sweetening agents comprise glycerin, monoammonium glycyrrhizinate, saccharin sodium, acesulfame potassium, high fructose corn syrup, and/or mixtures thereof. Pharmaceutical compositions of the invention include a flavoring system of the invention, a solvent system, and at least one pharmaceutically active agent, such as lopinavir or derivatives thereof, ritonavir or derivatives thereof, or mixtures thereof. Methods for making such liquid pharmaceutical compositions are also disclosed.
PCT/US2001/027415 2000-09-05 2001-09-04 Flavoring systems for pharmaceutical compositions and methods of making such compositions WO2002020057A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
MXPA03001952A MXPA03001952A (en) 2000-09-05 2001-09-04 Flavoring systems for pharmaceutical compositions and methods of making such compositions.
EP01968449A EP1315487A2 (en) 2000-09-05 2001-09-04 Flavoring systems for pharmaceutical compositions and methods of making such compositions
BRPI0108433-0A BR0108433A (en) 2000-09-05 2001-09-04 flavoring systems for pharmaceutical compositions and methods for making such compositions
CA002417258A CA2417258A1 (en) 2000-09-05 2001-09-04 Flavoring systems for pharmaceutical compositions and methods of making such compositions
JP2002524540A JP2004522698A (en) 2000-09-05 2001-09-04 Perfume systems for pharmaceutical compositions and methods for producing such compositions
AU2001288695A AU2001288695A1 (en) 2000-09-05 2001-09-04 Flavoring systems for pharmaceutical compositions and methods of making such compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65519200A 2000-09-05 2000-09-05
US09/655,192 2000-09-05

Publications (2)

Publication Number Publication Date
WO2002020057A2 WO2002020057A2 (en) 2002-03-14
WO2002020057A3 true WO2002020057A3 (en) 2002-05-10

Family

ID=24627898

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/027415 WO2002020057A2 (en) 2000-09-05 2001-09-04 Flavoring systems for pharmaceutical compositions and methods of making such compositions

Country Status (10)

Country Link
EP (1) EP1315487A2 (en)
JP (1) JP2004522698A (en)
AR (1) AR030715A1 (en)
AU (1) AU2001288695A1 (en)
BR (1) BR0108433A (en)
CA (1) CA2417258A1 (en)
MX (1) MXPA03001952A (en)
PE (1) PE20020373A1 (en)
UY (1) UY26925A1 (en)
WO (1) WO2002020057A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9107830B2 (en) 1999-11-12 2015-08-18 Abbvie, Inc. Inhibitors of crystallization in a solid dispersion

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05005335A (en) * 2002-11-22 2005-07-25 Firmenich & Cie Oral compositions which mask the salty taste of salts.
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
GB2423711B (en) * 2005-10-24 2007-02-14 Fortune Apex Dev Ltd Method for preparing a pharmaceutical composition with enhanced mucoadhesion
JPWO2013129436A1 (en) * 2012-02-29 2015-07-30 武田薬品工業株式会社 Oral
US8771651B2 (en) * 2012-09-10 2014-07-08 Johnson & Johnson Consumer Companies, Inc. Mouth rinses and tooth sensitivity treatment compositions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995020384A1 (en) * 1994-01-28 1995-08-03 Abbott Laboratories Pharmaceutical compositions containing hiv protease inhibitors
WO1997046222A1 (en) * 1996-06-03 1997-12-11 Merck & Co., Inc. Pediatric formulation for hiv protease inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995020384A1 (en) * 1994-01-28 1995-08-03 Abbott Laboratories Pharmaceutical compositions containing hiv protease inhibitors
WO1997046222A1 (en) * 1996-06-03 1997-12-11 Merck & Co., Inc. Pediatric formulation for hiv protease inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ABBOTT LABORATORIES: "Norvir", PRODUCT LABELING, NORVIR, March 2001 (2001-03-01), XP002189994, Retrieved from the Internet <URL:http://www.rxabbott.com/hiv/norpi.htm> [retrieved on 20020211] *
OHTA, YUKARI, ET AL.: "New drugs - Reports of new drugs recently approved by the FDA: Ritonavir", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 5, no. 3, 1997, gb, pages 461 - 462, XP001061208 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9107830B2 (en) 1999-11-12 2015-08-18 Abbvie, Inc. Inhibitors of crystallization in a solid dispersion

Also Published As

Publication number Publication date
EP1315487A2 (en) 2003-06-04
BR0108433A (en) 2006-06-06
AU2001288695A1 (en) 2002-03-22
PE20020373A1 (en) 2002-05-13
CA2417258A1 (en) 2002-03-14
MXPA03001952A (en) 2003-09-10
JP2004522698A (en) 2004-07-29
WO2002020057A2 (en) 2002-03-14
UY26925A1 (en) 2002-04-26
AR030715A1 (en) 2003-09-03

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