WO2002018622A3 - Recepteurs du facteur de necrose tumorale 6$g(a) et 6$g(b) - Google Patents

Recepteurs du facteur de necrose tumorale 6$g(a) et 6$g(b) Download PDF

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Publication number
WO2002018622A3
WO2002018622A3 PCT/US2001/026396 US0126396W WO0218622A3 WO 2002018622 A3 WO2002018622 A3 WO 2002018622A3 US 0126396 W US0126396 W US 0126396W WO 0218622 A3 WO0218622 A3 WO 0218622A3
Authority
WO
WIPO (PCT)
Prior art keywords
tnfr
necrosis factor
tumor necrosis
methods
factor receptors
Prior art date
Application number
PCT/US2001/026396
Other languages
English (en)
Other versions
WO2002018622A2 (fr
Inventor
Reiner L Gentz
Reinhard Ebner
Guo-Liang Yu
Steven M Ruben
Jian Ni
Ping Feng
Original Assignee
Human Genome Sciences Inc
Reiner L Gentz
Reinhard Ebner
Guo-Liang Yu
Steven M Ruben
Jian Ni
Ping Feng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc, Reiner L Gentz, Reinhard Ebner, Guo-Liang Yu, Steven M Ruben, Jian Ni, Ping Feng filed Critical Human Genome Sciences Inc
Priority to EP01966151A priority Critical patent/EP1322667A4/fr
Priority to AU2001286688A priority patent/AU2001286688A1/en
Priority to CA002420593A priority patent/CA2420593A1/fr
Publication of WO2002018622A2 publication Critical patent/WO2002018622A2/fr
Publication of WO2002018622A3 publication Critical patent/WO2002018622A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Cette invention se rapporte à de nouvelles protéines servant de récepteurs du facteur de nécrose tumorale (TNFR). Cette invention concerne en particulier des molécules d'acide nucléique isolées codant les protéines servant de TNFR 6α et 6β humains. Cette invention décrit en particulier des polypeptides TNFR 6α et 6β, ainsi que des vecteurs, des cellules hôtes et des procédés de recombinaison servant à leur production. Cette invention concerne enfin des procédés de criblage pour identifier des agonistes et des antagonistes de l'activité des TNFR 6α et 6β, ainsi que des procédés diagnostiques permettant de détecter des troubles liés au système immunitaire et des procédés thérapeutiques servant à traiter des troubles liés au système immunitaire.
PCT/US2001/026396 2000-08-25 2001-08-24 Recepteurs du facteur de necrose tumorale 6$g(a) et 6$g(b) WO2002018622A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01966151A EP1322667A4 (fr) 2000-08-25 2001-08-24 Recepteurs du facteur de necrose tumorale 6-alpha et 6-beta
AU2001286688A AU2001286688A1 (en) 2000-08-25 2001-08-24 Tumor necrosis factor receptors 6alpha and 6beta
CA002420593A CA2420593A1 (fr) 2000-08-25 2001-08-24 Recepteurs du facteur de necrose tumorale 6$g(a) et 6$g(b)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US22759800P 2000-08-25 2000-08-25
US60/227,598 2000-08-25
US25213100P 2000-11-21 2000-11-21
US60/252,131 2000-11-21
US30322401P 2001-07-06 2001-07-06
US60/303,224 2001-07-06

Publications (2)

Publication Number Publication Date
WO2002018622A2 WO2002018622A2 (fr) 2002-03-07
WO2002018622A3 true WO2002018622A3 (fr) 2002-08-29

Family

ID=27397742

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/026396 WO2002018622A2 (fr) 2000-08-25 2001-08-24 Recepteurs du facteur de necrose tumorale 6$g(a) et 6$g(b)

Country Status (4)

Country Link
EP (1) EP1322667A4 (fr)
AU (1) AU2001286688A1 (fr)
CA (1) CA2420593A1 (fr)
WO (1) WO2002018622A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190390278A1 (en) * 2017-01-26 2019-12-26 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5885800A (en) * 1997-02-04 1999-03-23 Smithkline Beecham Corporation DNA encoding tumor necrosis related receptor, TR4
WO1999014330A1 (fr) * 1997-09-18 1999-03-25 Genentech, Inc. HOMOLOGUE DU TNFR APPELE POLYPEPTIDE DcR3
WO1999050413A2 (fr) * 1998-03-30 1999-10-07 Eli Lilly And Company APPLICATIONS THERAPEUTIQUES DE POLYPEPTIDES mFLINT MURS, OU DE OPG3 EN TANT QUE MEMBRE DE LA SUPERFAMILLE DU RECEPTEUR DU TNF

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE92107T1 (de) * 1989-04-29 1993-08-15 Delta Biotechnology Ltd N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen.
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
GB9526733D0 (en) * 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
CA2277925A1 (fr) * 1997-01-14 1998-07-16 Human Genome Sciences, Inc. Recepteurs 6.alpha. et 6.beta. du facteur de necrose tumorale

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5885800A (en) * 1997-02-04 1999-03-23 Smithkline Beecham Corporation DNA encoding tumor necrosis related receptor, TR4
WO1999014330A1 (fr) * 1997-09-18 1999-03-25 Genentech, Inc. HOMOLOGUE DU TNFR APPELE POLYPEPTIDE DcR3
WO1999050413A2 (fr) * 1998-03-30 1999-10-07 Eli Lilly And Company APPLICATIONS THERAPEUTIQUES DE POLYPEPTIDES mFLINT MURS, OU DE OPG3 EN TANT QUE MEMBRE DE LA SUPERFAMILLE DU RECEPTEUR DU TNF

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK [online] 6 July 2001 (2001-07-06), MATTHEWS, L.: "Direct submission", XP002951131, Database accession no. (AL121845) *
LOCKSLEY ET AL.: "The TNF and TNF receptor superfamilies: integrating mammalian biology", CELL, vol. 104, 23 February 2001 (2001-02-23), pages 487 - 501, XP002951130 *
See also references of EP1322667A4 *

Also Published As

Publication number Publication date
AU2001286688A1 (en) 2002-03-13
EP1322667A2 (fr) 2003-07-02
WO2002018622A2 (fr) 2002-03-07
EP1322667A4 (fr) 2004-08-18
CA2420593A1 (fr) 2002-03-07

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