WO2001032128A3 - Chimiokine beta 13 humaine - Google Patents

Chimiokine beta 13 humaine Download PDF

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Publication number
WO2001032128A3
WO2001032128A3 PCT/US2000/030237 US0030237W WO0132128A3 WO 2001032128 A3 WO2001032128 A3 WO 2001032128A3 US 0030237 W US0030237 W US 0030237W WO 0132128 A3 WO0132128 A3 WO 0132128A3
Authority
WO
WIPO (PCT)
Prior art keywords
ckβ
methods
protein
immune system
related disorders
Prior art date
Application number
PCT/US2000/030237
Other languages
English (en)
Other versions
WO2001032128A9 (fr
WO2001032128A2 (fr
Inventor
Stephen Ullrich
George Seibel
Haodong Li
Francis W Luscinskas
Original Assignee
Human Genome Sciences Inc
Brigham & Womens Hospital
Smithkline Beecham Corp
Stephen Ullrich
George Seibel
Haodong Li
Francis W Luscinskas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc, Brigham & Womens Hospital, Smithkline Beecham Corp, Stephen Ullrich, George Seibel, Haodong Li, Francis W Luscinskas filed Critical Human Genome Sciences Inc
Priority to JP2001534336A priority Critical patent/JP2003514517A/ja
Priority to EP00978340A priority patent/EP1229795A4/fr
Priority to CA002387808A priority patent/CA2387808A1/fr
Priority to AU15813/01A priority patent/AU1581301A/en
Publication of WO2001032128A2 publication Critical patent/WO2001032128A2/fr
Publication of WO2001032128A3 publication Critical patent/WO2001032128A3/fr
Publication of WO2001032128A9 publication Critical patent/WO2001032128A9/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention concerne une nouvelle protéine CKβ-13 faisant partie de la famille des chimiokines. Elle porte notamment sur des molécules d'acide nucléique isolées codant pour la protéine CKβ-13 humaine. Des polypeptides CKβ-13 sont également décrits ainsi que des vecteurs, des cellules hôtes et des méthodes de recombinaison pour la production de ceux-ci. L'invention se rapporte encore à des méthodes de criblage permettant l'identification d'agonistes et d'antagonistes de l'activité de CKβ-13 ainsi qu'à des méthodes diagnostiques pour la détection de troubles liés au système immunitaire, et à des méthodes thérapeutiques pour le traitement de troubles relatifs au système immunitaire.
PCT/US2000/030237 1999-11-03 2000-11-02 Chimiokine beta 13 humaine WO2001032128A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001534336A JP2003514517A (ja) 1999-11-03 2000-11-02 ヒトケモカインβ−１３
EP00978340A EP1229795A4 (fr) 1999-11-03 2000-11-02 Chimiokine beta 13 humaine
CA002387808A CA2387808A1 (fr) 1999-11-03 2000-11-02 Chimiokine beta 13 humaine
AU15813/01A AU1581301A (en) 1999-11-03 2000-11-02 Human chemokine beta-13

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43276899A 1999-11-03 1999-11-03
US09/432,768 1999-11-03

Publications (3)

Publication Number Publication Date
WO2001032128A2 WO2001032128A2 (fr) 2001-05-10
WO2001032128A3 true WO2001032128A3 (fr) 2001-11-08
WO2001032128A9 WO2001032128A9 (fr) 2002-05-16

Family

ID=23717510

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/030237 WO2001032128A2 (fr) 1999-11-03 2000-11-02 Chimiokine beta 13 humaine

Country Status (5)

Country Link
EP (1) EP1229795A4 (fr)
JP (1) JP2003514517A (fr)
AU (1) AU1581301A (fr)
CA (1) CA2387808A1 (fr)
WO (1) WO2001032128A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6737513B1 (en) 1996-06-07 2004-05-18 Icos Corporation Macrophage derived chemokine (MDC) and chemokine analogs and assay to identify modulators of MDC activity, and therapeutic uses for same

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7018627B1 (en) 1995-06-07 2006-03-28 Icos Corporation Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof
US20060228331A1 (en) 2003-10-10 2006-10-12 Novo Nordisk A/S IL-21 Derivatives and variants
WO2005037306A1 (fr) * 2003-10-17 2005-04-28 Novo Nordisk A/S Therapie combinee

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039521A1 (fr) * 1995-06-06 1996-12-12 Human Genome Sciences, Inc. Chemokine beta-13 humaine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0869812B1 (fr) * 1995-11-30 2004-03-24 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES C-c chemokines inhibant l'infection par retrovirus
AU5383498A (en) * 1996-12-05 1998-06-29 Human Genome Sciences, Inc. Human chemokine beta-13

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039521A1 (fr) * 1995-06-06 1996-12-12 Human Genome Sciences, Inc. Chemokine beta-13 humaine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1229795A4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6737513B1 (en) 1996-06-07 2004-05-18 Icos Corporation Macrophage derived chemokine (MDC) and chemokine analogs and assay to identify modulators of MDC activity, and therapeutic uses for same

Also Published As

Publication number Publication date
AU1581301A (en) 2001-05-14
JP2003514517A (ja) 2003-04-22
CA2387808A1 (fr) 2001-05-10
EP1229795A2 (fr) 2002-08-14
WO2001032128A9 (fr) 2002-05-16
EP1229795A4 (fr) 2004-07-28
WO2001032128A2 (fr) 2001-05-10

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