CA2387808A1 - Chimiokine beta 13 humaine - Google Patents

Chimiokine beta 13 humaine Download PDF

Info

Publication number
CA2387808A1
CA2387808A1 CA002387808A CA2387808A CA2387808A1 CA 2387808 A1 CA2387808 A1 CA 2387808A1 CA 002387808 A CA002387808 A CA 002387808A CA 2387808 A CA2387808 A CA 2387808A CA 2387808 A1 CA2387808 A1 CA 2387808A1
Authority
CA
Canada
Prior art keywords
polypeptide
amino acid
seq
beta
nucleotide sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002387808A
Other languages
English (en)
Inventor
Stephen Ullrich
George Seibel
Haodong Li
Francis W. Luscinskas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
Human Genome Sciences Inc
SmithKline Beecham Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2387808A1 publication Critical patent/CA2387808A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une nouvelle protéine CK.beta.-13 faisant partie de la famille des chimiokines. Elle porte notamment sur des molécules d'acide nucléique isolées codant pour la protéine CK.beta.-13 humaine. Des polypeptides CK.beta.-13 sont également décrits ainsi que des vecteurs, des cellules hôtes et des méthodes de recombinaison pour la production de ceux-ci. L'invention se rapporte encore à des méthodes de criblage permettant l'identification d'agonistes et d'antagonistes de l'activité de CK.beta.-13 ainsi qu'à des méthodes diagnostiques pour la détection de troubles liés au système immunitaire, et à des méthodes thérapeutiques pour le traitement de troubles relatifs au système immunitaire.
CA002387808A 1999-11-03 2000-11-02 Chimiokine beta 13 humaine Abandoned CA2387808A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43276899A 1999-11-03 1999-11-03
US09/432,768 1999-11-03
PCT/US2000/030237 WO2001032128A2 (fr) 1999-11-03 2000-11-02 Chimiokine beta 13 humaine

Publications (1)

Publication Number Publication Date
CA2387808A1 true CA2387808A1 (fr) 2001-05-10

Family

ID=23717510

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002387808A Abandoned CA2387808A1 (fr) 1999-11-03 2000-11-02 Chimiokine beta 13 humaine

Country Status (5)

Country Link
EP (1) EP1229795A4 (fr)
JP (1) JP2003514517A (fr)
AU (1) AU1581301A (fr)
CA (1) CA2387808A1 (fr)
WO (1) WO2001032128A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6737513B1 (en) 1996-06-07 2004-05-18 Icos Corporation Macrophage derived chemokine (MDC) and chemokine analogs and assay to identify modulators of MDC activity, and therapeutic uses for same
US7018627B1 (en) 1995-06-07 2006-03-28 Icos Corporation Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof
US20060228331A1 (en) 2003-10-10 2006-10-12 Novo Nordisk A/S IL-21 Derivatives and variants
CA2542662A1 (fr) * 2003-10-17 2005-04-28 Novo Nordisk A/S Combinaisons pharmaceutiques comprenant de l'il-21

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9708528A (es) * 1995-06-06 1998-02-28 Human Genome Sciences Inc Quimiosina bata-13 humana.
DE69631971D1 (de) * 1995-11-30 2004-04-29 Us Government C-c chemokine die die infektion mit retoviren verhindern
CA2277580A1 (fr) * 1996-12-05 1998-06-11 Human Genome Sciences, Inc. Chimiokine beta-13 d'origine humaine

Also Published As

Publication number Publication date
EP1229795A2 (fr) 2002-08-14
WO2001032128A3 (fr) 2001-11-08
JP2003514517A (ja) 2003-04-22
WO2001032128A9 (fr) 2002-05-16
AU1581301A (en) 2001-05-14
WO2001032128A2 (fr) 2001-05-10
EP1229795A4 (fr) 2004-07-28

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Legal Events

Date Code Title Description
FZDE Dead