CA2420593A1 - Recepteurs du facteur de necrose tumorale 6$g(a) et 6$g(b) - Google Patents

Recepteurs du facteur de necrose tumorale 6$g(a) et 6$g(b) Download PDF

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Publication number
CA2420593A1
CA2420593A1 CA002420593A CA2420593A CA2420593A1 CA 2420593 A1 CA2420593 A1 CA 2420593A1 CA 002420593 A CA002420593 A CA 002420593A CA 2420593 A CA2420593 A CA 2420593A CA 2420593 A1 CA2420593 A1 CA 2420593A1
Authority
CA
Canada
Prior art keywords
amino acid
tnfr
seq
polypeptide
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002420593A
Other languages
English (en)
Inventor
Reiner L. Gentz
Reinhard Ebner
Guo-Liang Yu
Steven M. Ruben
Jian Ni
Ping Feng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Genome Sciences Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2420593A1 publication Critical patent/CA2420593A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Cette invention se rapporte à de nouvelles protéines servant de récepteurs du facteur de nécrose tumorale (TNFR). Cette invention concerne en particulier des molécules d'acide nucléique isolées codant les protéines servant de TNFR 6.alpha. et 6.beta. humains. Cette invention décrit en particulier des polypeptides TNFR 6.alpha. et 6.beta., ainsi que des vecteurs, des cellules hôtes et des procédés de recombinaison servant à leur production. Cette invention concerne enfin des procédés de criblage pour identifier des agonistes et des antagonistes de l'activité des TNFR 6.alpha. et 6.beta., ainsi que des procédés diagnostiques permettant de détecter des troubles liés au système immunitaire et des procédés thérapeutiques servant à traiter des troubles liés au système immunitaire.
CA002420593A 2000-08-25 2001-08-24 Recepteurs du facteur de necrose tumorale 6$g(a) et 6$g(b) Abandoned CA2420593A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US22759800P 2000-08-25 2000-08-25
US60/227,598 2000-08-25
US25213100P 2000-11-21 2000-11-21
US60/252,131 2000-11-21
US30322401P 2001-07-06 2001-07-06
US60/303,224 2001-07-06
PCT/US2001/026396 WO2002018622A2 (fr) 2000-08-25 2001-08-24 Recepteurs du facteur de necrose tumorale 6$g(a) et 6$g(b)

Publications (1)

Publication Number Publication Date
CA2420593A1 true CA2420593A1 (fr) 2002-03-07

Family

ID=27397742

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002420593A Abandoned CA2420593A1 (fr) 2000-08-25 2001-08-24 Recepteurs du facteur de necrose tumorale 6$g(a) et 6$g(b)

Country Status (4)

Country Link
EP (1) EP1322667A4 (fr)
AU (1) AU2001286688A1 (fr)
CA (1) CA2420593A1 (fr)
WO (1) WO2002018622A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018213315A1 (en) * 2017-01-26 2019-07-25 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE92107T1 (de) * 1989-04-29 1993-08-15 Delta Biotechnology Ltd N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen.
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
GB9526733D0 (en) * 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
CN1247567A (zh) * 1997-01-14 2000-03-15 人体基因组科学有限公司 肿瘤坏死因子受体6α和6β
US5885800A (en) * 1997-02-04 1999-03-23 Smithkline Beecham Corporation DNA encoding tumor necrosis related receptor, TR4
DK1015587T3 (da) * 1997-09-18 2008-08-25 Genentech Inc DcR3 polypeptid, en TNFR-homolog
HUP0102067A2 (hu) * 1998-03-30 2001-10-28 Eli Lilly And Co. A TNF receptorcsaládba tartozó érett FLINT (mFLINT) polipeptid vagy más néven az OPG3 terápiás alkalmazásai

Also Published As

Publication number Publication date
EP1322667A2 (fr) 2003-07-02
EP1322667A4 (fr) 2004-08-18
WO2002018622A2 (fr) 2002-03-07
WO2002018622A3 (fr) 2002-08-29
AU2001286688A1 (en) 2002-03-13

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Legal Events

Date Code Title Description
FZDE Dead